CN108703895A - A kind of long-acting moisturizing gel and preparation method of percdation - Google Patents
A kind of long-acting moisturizing gel and preparation method of percdation Download PDFInfo
- Publication number
- CN108703895A CN108703895A CN201810956924.7A CN201810956924A CN108703895A CN 108703895 A CN108703895 A CN 108703895A CN 201810956924 A CN201810956924 A CN 201810956924A CN 108703895 A CN108703895 A CN 108703895A
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- percdation
- long
- moisturizing gel
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- Granted
Links
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Abstract
The invention belongs to the technical fields of skin care item, provide a kind of long-acting moisturizing gel and preparation method of percdation.This method with aerosil, chitosan by adsorbing hyaluronic acid, it is carried on again in the hollow hole of polylactic acid doughnut, it is further mixed with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, methylcellulose, glycyrrhizic acid concentration powder, deionized water, moisturizing gel is made.Compared with conventional method, moisturizing gel prepared by the present invention, using acid fiber by polylactic to micro- needling action of skin, the hyaluronic acid carried is promoted to penetrate epidermis, and under the action of azone, menthol, organic amine, promote skin expansion, conducive to the further infiltration of hyaluronic acid, deep water supplement moisturizing is realized, and since hyaluronic acid is carried on the inside of doughnut, with slow releasing function, it can be achieved that long-acting moisturizing.
Description
Technical field
The invention belongs to the technical field of skin care item, long-acting moisturizing gel and the preparation side of a kind of percdation are provided
Method.
Background technology
Today's society, various seriously polluted, the destruction of ecological environment causes prodigious influence to the skin of people, includes mainly
Skin flavescence, aging, the colour of skin be dimmed, serious color spot also occur in lackluster etc. or even groups of people.Health skin should be
It is bright and clean moist flexible, and these appearance marks are related with the function of skin moisture-keeping system itself.The function of moisture-keeping system
It is that the water content for maintaining skin certain, sufficient aquation are conducive to enzymatic reaction and cuticula can be promoted ripe, keep
Stratum corneum flexibility.Therefore, the replenishing water and preserving moisture of skin is also the basis of modern beauty skin care.
External application moisturizer effect in moisturizing class skin care item lies also in supplement moisture of skin, and excessive water is prevented to be lost in, and protects
Hold the health status of skin.Moisture content of skin accounts for the 18 ~ 20% of whole body, and wherein in the dermis, cuticula is aqueous for moisture major storage
Amount only accounts for the 15 ~ 30% of epidermis, and horn cell contributes to maintenance skin appearance and sense quality after fully be hydrated, make skin it is bright and beautiful,
High resilience, and if water content of stratum corneum will have dry skin less than 10%.Hyaluronic acid in corium mechanism is reduced,
Mucopolysaccharide is denaturalized, and dermis vessel retraction and Vascular Permeability decrease can cause intradermal water content to decline, and make skin
There are the skin ageing phenomenons such as dry, matt, elasticity reduces, wrinkle increases.
The raw material of Moisturizer should have following characteristic：Wettability power is strong；With viscosity appropriate；Colourless nontoxic, nothing
Irritation, non-corrosive property；With good solubility, and can be with other substances compatibles；It is not oxidizable without detriment to matrix appearance.
Active ingredient in moisturizing class skin care item is broadly divided into natural moisture preserving agent and chemical synthesis moisturizer.Wherein natural moisture preserving agent has
Human skin proper constituent also has animal and plant extracts such as hyaluronic acid, ceramide, glycerine, such as honey, saualane, aloe
Extract etc.；Chemical synthesis moisturizer includes lactic acid, polyalcohols, pyrrolidone sodium carboxylate, chitin chitosan and its derivative
Object etc..Application of the gel-like skin care item in skin nursing moisturizing containing moisturizer is particularly taken seriously.
Chinese invention patent application number 201711226810.9 discloses a kind of aloes collagen moisturizing gel, belongs to day
Change technical field.The moisturizing gel includes following component：Deionized water, collagen, aloe barbadensis Miller leaf extract, centella
Extract, Brassica campestris L extract, glycerine, propylene glycol, acrylate, Sensiva SC50, triethanolamine, butanediol, PEG-60 hydrogen
Change castor oil, Cremophor RH40, methyl hydroxybenzoate, Phenoxyethanol, natto gum, essence.The moisturizing gel is with collagen
It is main component with a variety of natural plant extracts such as aloe vera extract, keeps the skin wet, delays for skin with excellent
The effect of solving skin problem, but moistening effect is held time short, is unable to reach long-acting moisturizing.
Chinese invention patent application number 201810112077.6 discloses a kind of moisturizing gel emulsion and preparation method thereof, should
The raw material of moisturizing gel emulsion includes：Rose hip oil, Gotu Kola P.E, grape seed oil, vitamin E, isopropyl myristate,
It is PEG-7 olives grease, lecithin, alkyl-glucoside, sodium alginate, 1,2- propylene glycol, water, stearyl alcohol, ethyl cellulose, hard
Acyl Sodium Hyaluronate, butanediol cocounut oil acid esters, methyl p-hydroxybenzoate, xanthan gum, xanthans, carbomer, citric acid.Its
Preparation method is that lotion first is made in rose hip oil, Gotu Kola P.E, grape seed oil, vitamin E and PEG-7 olive greases,
Then add hydrogel matrix xanthan gum, xanthans and carbomer to get.The invention has a defect that moisturizing ingredient can not
Percdation, and slow release effect unobvious.
In conclusion being used in the cosmetics of preserving moisture and protecting skin in the prior art, the active ingredients slow release such as hyaluronic acid is poor,
Be difficult to percdation so that moistening effect is undesirable, and the moisturizing duration is shorter, therefore develop one kind can percdation simultaneously
The skin-protection product of long-acting moisturizing, has great significance.
Invention content
As it can be seen that there are active ingredients to be difficult to percdation, and moistening effect for the preserving moisture and protecting skin gel cosmetic products of the prior art
It holds time the shortcomings of not long.For such case, it is proposed that the long-acting moisturizing gel and preparation method of a kind of percdation,
Moisturizing active ingredient percdation and slow release can be achieved, there is good long-acting moistening effect.
To achieve the above object, specific technical solution of the present invention is as follows：
A kind of preparation method of the long-acting moisturizing gel of percdation, the moisturizing gel preparation are as follows：
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made.
Preferably, step（1）In the colloidal solution, 55 ~ 70 parts by weight of low-molecular-weight hyaluronic acid, aerosil
20 ~ 30 parts by weight, 10 ~ 15 parts by weight of chitosan.
Preferably, step（1）The molecular weight of the low-molecular-weight hyaluronic acid is 50 ~ 800,000.
Preferably, step（1）The specific surface area of the aerosil is 200 ~ 500m2/ g, pore-size be 50 ~
100nm, porosity are 90 ~ 95%.
Preferably, step（2）The outer diameter of the polylactic acid doughnut is 0.4 ~ 0.8mm, and wall thickness is 0.1 ~ 0.2mm, long
Degree is 1 ~ 3mm.
Preferably, step（2）The ultrasonic frequency of the ultrasonic disperse is 40 ~ 60kHz, and power density is 0.5 ~ 0.8W/
cm2, the time is 20 ~ 50min.
Preferably, step（2）The vacuum degree of the vacuum processing is 10 ~ 50Pa, and processing time is 20 ~ 40min.
Preferably, step（3）In the moisturizing gel, 22 ~ 25 parts by weight of composite fibre, 0.5 ~ 2 parts by weight of azone, peppermint
0.5 ~ 2 parts by weight of alcohol, 1 ~ 2 parts by weight of organic amine, 2 ~ 4 parts by weight of stearic acid, 2 ~ 4 parts by weight of monoglyceride, 12 ~ 15 weight of carbomer
Measure part, 5 ~ 8 parts by weight of methylcellulose, 4 ~ 6 parts by weight of glycyrrhizic acid concentration powder, 32 ~ 51 parts by weight of deionized water.
Preferably, step（3）The organic amine is at least one of ethanol amine, diethanol amine, triethanolamine.
The present invention also provides a kind of long-acting moisturizing gels for the percdation that above-mentioned preparation method is prepared.The length
Moisturizing gel is imitated by adsorbing hyaluronic acid with aerosil, chitosan, then being carried in polylactic acid doughnut
It is further dense with azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, methylcellulose, glycyrrhizic acid in emptying aperture
Contracting powder, deionized water are mixed and are made.
The present invention provides the long-acting moisturizing gels and preparation method of a kind of percdation, compared with prior art, dash forward
The characteristics of going out and excellent effect are：
1. moisturizing gel prepared by the present invention is adsorbed hyaluronic acid, and is carried on polylactic acid with aerosil, chitosan
In the hollow hole of doughnut, the slow release of hyaluronic acid is realized, scattering and disappearing for hyaluronic acid is prevented, to realize long-acting guarantor
It is wet.
2. moisturizing gel prepared by the present invention carries hyaluronic acid by polylactic acid doughnut, using polylactic acid fibre
Micro- needling action to skin is tieed up, promotes hyaluronic acid to penetrate epidermis, basis is provided for percdation.
3. moisturizing gel prepared by the present invention promotes skin expansion by the effect of azone, menthol, organic amine, into one
Step promotes active principle to reach skin depths, realizes percdation, hence it is evident that improves moistening effect and persistence.
Specific implementation mode
In the following, the present invention will be further described in detail by way of specific embodiments, but this should not be interpreted as to the present invention
Range be only limitted to example below.Without departing from the idea of the above method of the present invention, according to ordinary skill
The various replacements or change that knowledge and customary means are made, should be included in the scope of the present invention.
Embodiment 1
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；In colloidal solution, low point
63 parts by weight of son amount hyaluronic acid, 24 parts by weight of aerosil, 13 parts by weight of chitosan；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；Being averaged for polylactic acid doughnut is outer
Diameter is 0.5mm, average wall thickness 0.1mm, average length 2mm；The ultrasonic frequency of ultrasonic disperse is 48kHz, power density
For 0.7W/cm2, time 30min；The vacuum degree of vacuum processing is 30Pa, processing time 32min；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made；It is organic
Amine is ethanol amine；In moisturizing gel, 23 parts by weight of composite fibre, 1 parts by weight of azone, 1 parts by weight of menthol, 2 weight of organic amine
Part, the concentration of 3 parts by weight of stearic acid, 3 parts by weight of monoglyceride, 13 parts by weight of carbomer, 7 parts by weight of methylcellulose, glycyrrhizic acid
5 parts by weight of powder, 42 parts by weight of deionized water.
Embodiment 2
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；In colloidal solution, low point
70 parts by weight of son amount hyaluronic acid, 20 parts by weight of aerosil, 10 parts by weight of chitosan；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；Being averaged for polylactic acid doughnut is outer
Diameter is 0.4mm, average wall thickness 0.1mm, average length 1mm；The ultrasonic frequency of ultrasonic disperse is 40kHz, power density
For 0.5W/cm2, time 50min；The vacuum degree of vacuum processing is 10Pa, processing time 40min；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made；It is organic
Amine is diethanol amine；In moisturizing gel, 22 parts by weight of composite fibre, 0.5 parts by weight of azone, 0.5 parts by weight of menthol, organic amine
1 parts by weight, 2 parts by weight of stearic acid, 2 parts by weight of monoglyceride, 12 parts by weight of carbomer, 5 parts by weight of methylcellulose, glycyrrhizic acid
Concentrate 4 parts by weight of powder, 51 parts by weight of deionized water.
Embodiment 3
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；In colloidal solution, low point
55 parts by weight of son amount hyaluronic acid, 30 parts by weight of aerosil, 15 parts by weight of chitosan；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；Being averaged for polylactic acid doughnut is outer
Diameter is 0.8mm, average wall thickness 0.2mm, average length 3mm；The ultrasonic frequency of ultrasonic disperse is 60kHz, power density
For 0.8W/cm2, time 20min；The vacuum degree of vacuum processing is 50Pa, processing time 20min；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made；It is organic
Amine is triethanolamine；In moisturizing gel, 5 parts by weight of composite fibre, 2 parts by weight of azone, 2 parts by weight of menthol, 2 weight of organic amine
Part, the concentration of 4 parts by weight of stearic acid, 4 parts by weight of monoglyceride, 15 parts by weight of carbomer, 8 parts by weight of methylcellulose, glycyrrhizic acid
6 parts by weight of powder, 32 parts by weight of deionized water.
Embodiment 4
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；In colloidal solution, low point
66 parts by weight of son amount hyaluronic acid, 22 parts by weight of aerosil, 12 parts by weight of chitosan；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；Being averaged for polylactic acid doughnut is outer
Diameter is 0.5mm, average wall thickness 0.1mm, average length 1.5mm；The ultrasonic frequency of ultrasonic disperse is 45kHz, and power is close
Degree is 0.6W/cm2, time 40min；The vacuum degree of vacuum processing is 20Pa, processing time 35min；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made；It is organic
Amine is ethanol amine；In moisturizing gel, 23 parts by weight of composite fibre, 1 parts by weight of azone, 1 parts by weight of menthol, 1 weight of organic amine
Part, the concentration of 2 parts by weight of stearic acid, 3 parts by weight of monoglyceride, 13 parts by weight of carbomer, 6 parts by weight of methylcellulose, glycyrrhizic acid
4 parts by weight of powder, 46 parts by weight of deionized water.
Embodiment 5
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；In colloidal solution, low point
59 parts by weight of son amount hyaluronic acid, 27 parts by weight of aerosil, 14 parts by weight of chitosan；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；Being averaged for polylactic acid doughnut is outer
Diameter is 0.7mm, average wall thickness 0.2mm, average length 2.5mm；The ultrasonic frequency of ultrasonic disperse is 55kHz, and power is close
Degree is 0.7W/cm2, time 30min；The vacuum degree of vacuum processing is 40Pa, processing time 25min；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made；It is organic
Amine is diethanol amine；In moisturizing gel, 24 parts by weight of composite fibre, 1.5 parts by weight of azone, 1.5 parts by weight of menthol, organic amine
2 parts by weight, 3 parts by weight of stearic acid, 4 parts by weight of monoglyceride, 14 parts by weight of carbomer, 7 parts by weight of methylcellulose, glycyrrhizic acid
Concentrate 6 parts by weight of powder, 37 parts by weight of deionized water.
Embodiment 6
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；In colloidal solution, low point
62 parts by weight of son amount hyaluronic acid, 25 parts by weight of aerosil, 13 parts by weight of chitosan；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；Being averaged for polylactic acid doughnut is outer
Diameter is 0.6mm, average wall thickness 0.2mm, average length 2mm；The ultrasonic frequency of ultrasonic disperse is 50kHz, power density
For 0.6W/cm2, time 35min；The vacuum degree of vacuum processing is 30Pa, processing time 30min；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made；It is organic
Amine is triethanolamine；In moisturizing gel, 24 parts by weight of composite fibre, 1 parts by weight of azone, 1 parts by weight of menthol, 2 weight of organic amine
Amount part, 3 parts by weight of stearic acid, 3 parts by weight of monoglyceride, 14 parts by weight of carbomer, 6 parts by weight of methylcellulose, glycyrrhizic acid are dense
5 parts by weight of contracting powder, 41 parts by weight of deionized water.
Comparative example 1
In preparation process, polylactic acid doughnut is not used, hyaluronic acid colloidal solution is loaded, other preparation conditions and reality
It is consistent to apply example 6.
Comparative example 2
In preparation process, it is not added with azone, menthol, organic amine, other preparation conditions are consistent with embodiment 6.
Performance test：
Healthy volunteer 30 is selected, male 15, women 15, the age, all subjects were without any skin at 30 ~ 60 years old
Skin or systemic disease history, recipient site（Inboard arm）Skin is without exception, does not also smear any external used medicine and cosmetics etc.
External preparation；Test environment temperature remains（22±1）DEG C, relative humidity remains 50 ± 5%, and volunteer need to shift to an earlier date before testing
Into test environment, rest 30min（Shell temperature, the temporary skin condition such as mood, sweat and fat secretion reach unified）；
Select the left and right inboard arm of subject away from palm base portion 5cm at；The identical region of several areas is defined in left forearm（4cm×
4cm）As using area；The point of right forearm same position is surveyed simultaneously as blank control region, the corresponding region of left and right forearm
Examination；In subject sample is smeared in arm Experimental Area；1h, 2h, 4h and 8h after smearing, are surveyed using CorneometerCM825
The hydration status of skin is tried, TewameterTM300 tests the water loss amount of skin, measures 5 times, obtains 5 measured values,
And it is averaged；Blank value is the average value of 5 hydration status relative values and moisture loss value measuring at the 0h moment；By 30
Name subject smears the data measured when same sample and is averaged.
The data obtained is as shown in table 1.
Table 1：
Claims (10)
1. a kind of preparation method of the long-acting moisturizing gel of percdation, which is characterized in that the moisturizing gel is prepared specific
Steps are as follows：
（1）Low-molecular-weight hyaluronic acid, aerosil, chitosan are mixed, colloidal solution is made；
（2）To step（1）Polylactic acid doughnut is added in colloidal solution obtained, ultrasonic disperse is uniform, then carries out at vacuum
Reason, makes colloidal solution be filled in the hollow hole of polylactic acid doughnut, and composite fibre is made；
（3）By step（2）Composite fibre obtained and azone, menthol, organic amine, stearic acid, monoglyceride, carbomer, first
Base cellulose, glycyrrhizic acid concentration powder, deionized water are mixed and stirred for uniformly, the long-acting moisturizing gel of percdation being made.
2. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（1）In the colloidal solution, 55 ~ 70 parts by weight of low-molecular-weight hyaluronic acid, 20 ~ 30 parts by weight of aerosil, chitosan
10 ~ 15 parts by weight.
3. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（1）The molecular weight of the low-molecular-weight hyaluronic acid is 50 ~ 800,000.
4. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（1）The specific surface area of the aerosil is 200 ~ 500m2/ g, pore-size be 50 ~ 100nm, porosity be 90 ~
95%。
5. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（2）The outer diameter of the polylactic acid doughnut is 0.4 ~ 0.8mm, and wall thickness is 0.1 ~ 0.2mm, and length is 1 ~ 3mm.
6. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（2）The ultrasonic frequency of the ultrasonic disperse is 40 ~ 60kHz, and power density is 0.5 ~ 0.8W/cm2, the time is 20 ~ 50min.
7. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（2）The vacuum degree of the vacuum processing is 10 ~ 50Pa, and processing time is 20 ~ 40min.
8. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（3）It is 22 ~ 25 parts by weight of composite fibre, 0.5 ~ 2 parts by weight of azone, 0.5 ~ 2 parts by weight of menthol, organic in the moisturizing gel
1 ~ 2 parts by weight of amine, 2 ~ 4 parts by weight of stearic acid, 2 ~ 4 parts by weight of monoglyceride, 12 ~ 15 parts by weight of carbomer, methylcellulose 5 ~ 8
Parts by weight, 4 ~ 6 parts by weight of glycyrrhizic acid concentration powder, 32 ~ 51 parts by weight of deionized water.
9. the preparation method of the long-acting moisturizing gel of a kind of percdation according to claim 1, it is characterised in that：Step
（3）The organic amine is at least one of ethanol amine, diethanol amine, triethanolamine.
10. a kind of long-acting moisturizing gel for percdation that any one of claim 1 ~ 9 preparation method is prepared.
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| CN112999119A (en) * | 2021-03-24 | 2021-06-22 | 蒋涛 | Gel-like cosmetic with lasting moisturizing function and preparation method thereof |
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| CN108837148A (en) * | 2018-07-20 | 2018-11-20 | 成都新柯力化工科技有限公司 | A kind of insulin cutaneous penetration patch and preparation method for diabetes |
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| CN111991348A (en) * | 2020-09-01 | 2020-11-27 | 江西省科达动物药业有限公司 | Doramectin sustained-release microcapsule injection |
| CN112999119A (en) * | 2021-03-24 | 2021-06-22 | 蒋涛 | Gel-like cosmetic with lasting moisturizing function and preparation method thereof |
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