CN109044907A - Painless transdermal beauty microneedle patch of one kind and preparation method thereof - Google Patents
Painless transdermal beauty microneedle patch of one kind and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
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Abstract
The present invention relates to a kind of painless transdermal beauty microneedle patches, including substrate and the needle body being fixed in substrate, the substrate is prepared by the aqueous solution of Sodium Hyaluronate, and the needle body is prepared by the effective component of following parts by weight: 10-17 parts of Sodium Hyaluronate, 0.8-2.1 parts of Arbutin, lactic acid 0.5-1.8,13-19 parts of collagen, 8-13 parts of vitamin E, 13-24 parts of L-cysteine, 11-16 parts of glutathione, 16-21 parts of mulberry-leaf extract, 200-350 parts of deionized water.Microneedle patch of the invention can make the effective component with functions such as water conservation, nti-freckle and smoothing wrinkles penetrate into human skin and be absorbed by rete vasculosum, microtrauma caused by micropin not will cause scar, the regeneration of skin can be stimulated instead, human epidermal cell is activated, to repair to human skin；The microneedle patch can be effectively prevented from pain caused by beauty locally injecting and infection, securely and reliably.
Description
Technical field
The present invention relates to a kind of painless transdermal beauty microneedle patches, belong to technical field of skin care.
Background technique
With advancing age, the inevitable aging of human body, and skin is the organ for showing aging at first, when human body goes out
When existing aging, skin of face will form wrinkle and color spot, and drug cosmetics and surgery beauty are two kinds of main intervention forms, but by
In the barrier action of keratoderma, the effective component of general crease-resistant class and nti-freckle class skin care item is difficult to be absorbed into epidermis base
Bottom and dermal sites, play the curative effect of crease-resistant and nti-freckle, surgery beauty then have applicability is not wide, risk is high, complication and
The disadvantages of side effect is more.
In recent years, micropin beauty is increasingly used by users, micropin can pierce through the stratum corneum barrier of skin, generate
Microchannel increases the infiltration of drug, and drug penetrates into the capillary network of dermal layer of the skin by micropin hole, with blood circulation
Through treatment target position, can reach enough, purpose is quickly administered, greatly reduce the dosage of drug and improve the treatment of drug
Effect.Sharp since micropin is thin, general paracentesis depth is only in cuticula and dermis, not in contact with nerve endings is arrived, reduces
To the degree of injury of body tissue, while skin corium is stimulated, percutaneous self-healing ability promotes ossein hyperplasia.Therefore, micro-
Needle is transdermal to import the best mode that drug mode is safe and efficient and painless administration.
Micropin beauty curing is originated from France, is widely used in Japan, South Korea, America and Europe at present.The product master listed at present
If the hyaluronic acid micropin eye sticker of the not drug containing based on South Korea ROYAL SKIN and Japan's YOOKO brand, though hyaluronic acid
Filling skin histology and water retaining function can be played, is but difficult to meet the needs of contemporary schoolgirl fights pigmentation, smoothing wrinkle etc..
Summary of the invention
It is an object of the invention to solve above-mentioned deficiency, a kind of painless transdermal beauty microneedle patch is provided, water conservation is had both, dispels
The functions such as spot and smoothing wrinkle have preferably reparation and cosmetic result to skin.
Another object of the present invention, which also resides in, provides the preparation method of above-mentioned painless transdermal beauty microneedle patch.
Technical solution
A kind of painless transdermal beauty microneedle patch, including substrate and the needle body being fixed in substrate, the substrate is by molecular weight
It is 2 × 106-3×106The aqueous solution of Sodium Hyaluronate be prepared, the needle body is prepared by the effective component of following parts by weight
It forms:
Molecular weight is 10-17 parts of Sodium Hyaluronate of 6000-8000,0.8-2.1 parts of Arbutin, 0.5-1.8 parts of lactic acid, and glue
Former albumen 13-19 parts, 8-13 parts of vitamin E, 13-24 parts of L-cysteine, 11-16 parts of glutathione, mulberry-leaf extract 16-
21 parts, 200-350 parts of deionized water.
Further, the needle body is prepared by the effective component of following parts by weight: 12-15 parts of hyaluronic acid, Arbutin
1-1.8 parts, 0.8-1.5 parts of lactic acid, 15-18 parts of collagen, 9-12 parts of vitamin E, 15-20 parts of L-cysteine, gluathione
12-15 parts of peptide, 17-20 parts of mulberry-leaf extract, 240-300 parts of deionized water.
Further, the needle body is prepared by the effective component of following parts by weight: 14 parts of hyaluronic acid, Arbutin 1.5
Part, 1.2 parts of lactic acid, 16 parts of collagen, 10 parts of vitamin E, 18 parts of L-cysteine, 13 parts of glutathione, mulberry-leaf extract
18 parts, 280 parts of deionized water.
Further, the molecular weight is 2 × 106-3×106Sodium Hyaluronate aqueous solution mass concentration be 0.8-
1.5%.
Further, the needle body is rectangular pyramid, and needle level is 400-750 microns, 8-12 microns of tip diameter.This hair
Bright people shows that rectangular pyramid micropin has the study found that the axial moment of inertia of rectangular pyramid is 1.69 times of comparable size cone
There is higher peronium efficiency.
The preparation method of the mulberry-leaf extract: with the mulberry leaf powder of the 1st~3 young leaves processing on mulberry branch before the Frost's Descent
For raw material, after drying in the shade, crushing, respectively with n-butanol, the heating extraction of 90% second alcohol and water, and be spray-dried to get.
The preparation method of above-mentioned painless transdermal beauty microneedle patch, includes the following steps:
(1) each effective component of microneedle patch is thoroughly mixed uniformly in proportion, obtains needle body after vacuum defoamation processing
Preparation solution；
(2) needle body preparation solution is circulated into female mold, after needle body preparation solution fills up mold pin hole, then by hyalomitome
The aqueous solution of sour sodium covers on the mold containing needle body preparation solution, dry at 15-45 DEG C of temperature and the humidity of 30-50%
8-12h, after demoulding to get.
The mold used in above-mentioned preparation method for PMDS former, the design method of mold using this field routine
Technology.
Beneficial effects of the present invention: saturating by microneedle array the present invention provides a kind of painless transdermal beauty microneedle patch
The mode of skin injection can make the effective component with functions such as water conservation, nti-freckle and smoothing wrinkles penetrate into human skin and by rete vasculosum
It absorbs, small wound caused by micropin not will cause scar, can stimulate the regeneration of skin instead, and activation people's epidermis is thin
Born of the same parents, to be repaired to human skin；Pain caused by beauty locally injecting and infection can be effectively avoided in microneedle patch,
Securely and reliably, and material used in microneedle patch of the invention be it is safe, it is without side-effects.
Detailed description of the invention
Fig. 1 is the electron microscope of painless transdermal beauty microneedle patch made from embodiment 1.
Specific embodiment
The contents of the present invention are further elaborated combined with specific embodiments below, it is raw materials used in following embodiment to be
Commercially available common raw material.
Remarks: in preparation method, the design method of mold used is using the ordinary skill in the art.For the ease of
Compare, design parameter is consistent: needle body is rectangular pyramid, and needle level is 600 microns, 10 microns of tip diameter, needle point spacing
500 microns, 10 × 10 row of array, 100 needle bodies, microneedle array is having a size of 1cm × 1cm.It is converted by digital-to-analogue by design drawing
Conversion digitlization machine tool digital information, select respectively brass and stainless steel as rapidoprint according to design size into
Then row machine-shaping utilizes formpiston, prepare PMDS former.
Embodiment 1
A kind of painless transdermal beauty microneedle patch, including substrate and the needle body being fixed in substrate, the substrate is by molecular weight
It is 2 × 106-3×106The aqueous solution of Sodium Hyaluronate be prepared, the mass concentration of aqueous solution of sodium hyaluronate is 1.5%,
The needle body is prepared by the effective component of following parts by weight: 14 parts of hyaluronic acid, 1.5 parts of Arbutin, and 1.2 parts of lactic acid, glue
Former protein 16 part, 10 parts of vitamin E, 18 parts of L-cysteine, 13 parts of glutathione, 18 parts of mulberry-leaf extract, deionized water
280 parts.
The preparation method of above-mentioned painless transdermal beauty microneedle patch, includes the following steps:
(1) each effective component of microneedle patch is thoroughly mixed uniformly in proportion, obtains needle body after vacuum defoamation processing
Preparation solution；
(2) needle body preparation solution is circulated into female mold, after needle body preparation solution fills up mold pin hole, then by hyalomitome
The aqueous solution of sour sodium covers on the mold containing needle body preparation solution, and dry 9h, takes off at 25 DEG C of temperature and 40% humidity
After mould to get.
The electron microscope of painless transdermal beauty microneedle patch of the invention is shown in Fig. 1.
Embodiment 2
A kind of painless transdermal beauty microneedle patch, including substrate and the needle body being fixed in substrate, the substrate is by molecular weight
It is 2 × 106-3×106The aqueous solution of Sodium Hyaluronate be prepared, the mass concentration of aqueous solution of sodium hyaluronate is 1.2%,
The needle body is prepared by the effective component of following parts by weight: 12 parts of hyaluronic acid, 1.2 parts of Arbutin, and 1.0 parts of lactic acid, glue
Former protein 18 part, 12 parts of vitamin E, 15 parts of L-cysteine, 14 parts of glutathione, 20 parts of mulberry-leaf extract, deionized water
300 parts.
The preparation method of above-mentioned painless transdermal beauty microneedle patch, includes the following steps:
(1) each effective component of microneedle patch is thoroughly mixed uniformly in proportion, obtains needle body after vacuum defoamation processing
Preparation solution；
(2) needle body preparation solution is circulated into female mold, after needle body preparation solution fills up mold pin hole, then by hyalomitome
The aqueous solution of sour sodium covers on the mold containing needle body preparation solution, and dry 10h, takes off at 35 DEG C of temperature and 30% humidity
After mould to get.
Embodiment 3
A kind of painless transdermal beauty microneedle patch, including substrate and the needle body being fixed in substrate, the substrate is by molecular weight
It is 2 × 106-3×106The aqueous solution of Sodium Hyaluronate be prepared, the mass concentration of aqueous solution of sodium hyaluronate is 0.8%,
The needle body is prepared by the effective component of following parts by weight: 13 parts of hyaluronic acid, 1 part of Arbutin, and 0.8 part of lactic acid, collagen
Protein 15 part, 12 parts of vitamin E, 16 parts of L-cysteine, 15 parts of glutathione, 20 parts of mulberry-leaf extract, deionized water 260
Part.
The preparation method of above-mentioned painless transdermal beauty microneedle patch, includes the following steps:
(1) each effective component of microneedle patch is thoroughly mixed uniformly in proportion, obtains needle body after vacuum defoamation processing
Preparation solution；
(2) needle body preparation solution is circulated into female mold, after needle body preparation solution fills up mold pin hole, then by hyalomitome
The aqueous solution of sour sodium covers on the mold containing needle body preparation solution, and dry 10h, takes off at 40 DEG C of temperature and 50% humidity
After mould to get.
Effect test:
1. peronium rate is tested
Since the institutional framework of porcine skin is close with application on human skin institutional framework, application on human skin is replaced with porcine skin.Respectively
The micropin tip alignment pigskin surface layer of embodiment 1-3 is vertically pierced into, with the back side of hand pressing microneedle patch, the time of pressing is
3min, then with 0.2% Trypan Blue 2h, pig skin surfaces are cleaned up with 0.9% physiological saline, observes and counts quilt
The pinhole number of dyeing, micropin peronium rate=(dyeing pinhole number/total micropin number) × 100%.
Pig skin surfaces after the micropin effect of pigskin after observation effect under an optical microscope, embodiment 1 and embodiment 2
Have 100 clearly pin holes, effective peronium rate is 100%, the pig skin surfaces after the micropin effect of embodiment 3 have 99 it is clear
Pin hole, effective peronium rate be 99%, this illustrate micropin of the invention have enough hardness can pierce keratoderma enter
The intradermal delivering for realizing effective component.
2. fracture strength is tested
Microneedle patch prepared by embodiment 1-3 carries out fracture strength test, and needle point is placed in food texture measurement upward at room temperature
On test table, using the mode that is compressed axially, displacement-stress changing curve is measured, is increased with compression displacement, compression stress is fast
Speed rises, and when decline suddenly occurs in stress, as axially critical receiving maximum stress, institute's recording compressed stress value are micro- to micropin
The fracture strength of needle, test result are shown in Table 1:
Table 1
| Microneedle patch | Mechanical strength (N) |
| Embodiment 1 | 45.49±5.15 |
| Embodiment 2 | 40.18±4.16 |
| Embodiment 3 | 30.78±3.56 |
The single needle fracture strength of the microneedle patch of embodiment 1-3 preparation is 0.13-0.19N, greater than puncturing fell cuticula institute
Need minimum stress 0.1N, meet puncture fell answer force request.
3. by the beauty microneedle patch product of the microneedle patch of embodiment 1 and certain Japanese brand leading in the world, South Korea's brand
The test for carrying out intensity etc., the results are shown in Table 2:
Table 2
4. it is 30-55 years old that the present inventor, which from numerous volunteers, has selected age bracket, face has wrinkle, cutis laxa
Or 200 volunteers with different degrees of color spot, wherein male to female ratio respectively accounts for half, and 200 volunteers are randomly divided into four
Group, 2 groups of example 1 group, 2 groups of embodiment, 1 group of control and control, each group quantity of man and woman and in terms of without significant
Sex differernce is comparable.Volunteer in example 1 group is using the microneedle patch product in the embodiment of the present invention 1, every 3 angel
It with primary a, 30min, is only washed one's face daily with clear water, does not use other skin care item；Volunteer in 2 groups of embodiment is using this
Microneedle patch product in inventive embodiments 2, using primary a, 30min, daily is washed one's face with clear water within every 3 days, does not use other
Skin care item；The volunteer in 1 group is compareed using certain commercially available brand whitening and spot eliminating cream, daily using once, is only washed daily with clear water
Face does not use other skin care item；The volunteer compareed in 2 groups washes one's face only with clear water, does not have to other any skin care item.Tracking 60
After it, compare curative effect, criterion of therapeutical effect divides significant effect, effective and 3 kinds invalid, significant effect: spot or wrinkle disappear；It is effective:
Spot or wrinkle shoal；Invalid: skin is without significant change.Experimental result is shown in Table 3:
Table 3
| The significant number of effect | Efficiently individual quantity | Invalid number | It is efficient | |
| Example 1 group | 18 | 28 | 5 | 92% |
| 2 groups of embodiment | 15 | 27 | 9 | 84% |
| Compare 1 group | 5 | 12 | 33 | 34% |
| Compare 2 groups | 0 | 0 | 50 | 0 |
It can be seen that the product that the embodiment of the present invention 1 and 2 provides from the experimental result in table 3 and be substantially better than direct smearing
Commercially available whitening and spot eliminating cream, the especially microneedle patch product of embodiment 1, after tracking 60 days, total effective rate is up to 92%.
Above-described embodiment is only preferred embodiment of the invention, and but it cannot be understood as to patent of invention range
Limitation.It should be pointed out that for those of ordinary skill in the art, without departing from the inventive concept of the premise,
Various modifications and improvements can be made, and these are all within the scope of protection of the present invention.Therefore, the scope of protection of the patent of the present invention
It should be determined by the appended claims.
Claims (6)
1. a kind of painless transdermal beauty microneedle patch, which is characterized in that including substrate and the needle body being fixed in substrate, the substrate
It is 2 × 10 by molecular weight6-3×106The aqueous solution of Sodium Hyaluronate be prepared, the needle body is effective by following parts by weight
Ingredient is prepared:
Molecular weight is 10-17 parts of Sodium Hyaluronate of 6000-8000,0.8-2.1 parts of Arbutin, 0.5-1.8 parts of lactic acid, and collagen egg
It is 13-19 parts white, 8-13 parts of vitamin E, 13-24 parts of L-cysteine, 11-16 parts of glutathione, 16-21 parts of mulberry-leaf extract,
200-350 parts of deionized water.
2. painless transdermal beauty microneedle patch as described in claim 1, which is characterized in that the needle body is had by following parts by weight
Effect ingredient is prepared: 12-15 parts of hyaluronic acid, 1-1.8 parts of Arbutin, and 0.8-1.5 parts of lactic acid, 15-18 parts of collagen, dimension
Raw 9-12 parts of E of element, 15-20 parts of L-cysteine, 12-15 parts of glutathione, 17-20 parts of mulberry-leaf extract, deionized water 240-
300 parts.
3. painless transdermal beauty microneedle patch as claimed in claim 2, which is characterized in that the needle body is had by following parts by weight
Effect ingredient is prepared: 14 parts of hyaluronic acid, 1.5 parts of Arbutin, and 1.2 parts of lactic acid, 16 parts of collagen, 10 parts of vitamin E,
18 parts of L-cysteine, 13 parts of glutathione, 18 parts of mulberry-leaf extract, 280 parts of deionized water.
4. painless transdermal beauty microneedle patch as described in claim 1, which is characterized in that the molecular weight is 2 × 106-3×106
Sodium Hyaluronate aqueous solution mass concentration be 0.8-1.5%.
5. the painless transdermal beauty microneedle patch as described in Claims 1-4, which is characterized in that the needle body is rectangular pyramid, needle
Body height is 400-750 microns, 8-12 microns of tip diameter.
6. the preparation method of claim 1 to the 5 painless transdermal beauty microneedle patch, which comprises the steps of:
(1) each effective component of microneedle patch is thoroughly mixed uniformly in proportion, needle body preparation is obtained after vacuum defoamation processing
Liquid；
(2) needle body preparation solution is circulated into female mold, after needle body preparation solution fills up mold pin hole, then by Sodium Hyaluronate
Aqueous solution cover on the mold containing needle body preparation solution, the dry 8- at 15-45 DEG C of temperature and the humidity of 30-50%
12h, after demoulding to get.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811004739.4A CN109044907A (en) | 2018-08-30 | 2018-08-30 | Painless transdermal beauty microneedle patch of one kind and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811004739.4A CN109044907A (en) | 2018-08-30 | 2018-08-30 | Painless transdermal beauty microneedle patch of one kind and preparation method thereof |
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| CN109044907A true CN109044907A (en) | 2018-12-21 |
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| CN201811004739.4A Pending CN109044907A (en) | 2018-08-30 | 2018-08-30 | Painless transdermal beauty microneedle patch of one kind and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN111297727A (en) * | 2019-12-25 | 2020-06-19 | 华熙生物科技股份有限公司 | Beautifying and plasticizing treatment composition and application thereof |
| CN111840095A (en) * | 2020-07-29 | 2020-10-30 | 广东工业大学 | Hyaluronic acid soluble microarray film and preparation method thereof |
| CN112641656A (en) * | 2020-12-30 | 2021-04-13 | 宇肽生物(东莞)有限公司 | Polypeptide microneedle and preparation method thereof |
| CN113520905A (en) * | 2021-03-25 | 2021-10-22 | 甘肃天际生物科技有限公司 | Instant collagen microneedle and preparation method thereof |
| US20230414844A1 (en) * | 2022-06-24 | 2023-12-28 | Hangzhou Singclean Medical Products Co., Ltd | Cross-linked hydrogel microneedle for transdermal drug delivery and method for preparing the same |
| WO2024117132A1 (en) * | 2022-11-28 | 2024-06-06 | コスメディ製薬株式会社 | Collagen microneedle preparation |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297727A (en) * | 2019-12-25 | 2020-06-19 | 华熙生物科技股份有限公司 | Beautifying and plasticizing treatment composition and application thereof |
| CN111300702A (en) * | 2020-02-03 | 2020-06-19 | 康迈丽德(深圳)生物科技有限公司 | Preparation method of polymer microneedle and polymer microneedle |
| CN111840095A (en) * | 2020-07-29 | 2020-10-30 | 广东工业大学 | Hyaluronic acid soluble microarray film and preparation method thereof |
| CN112641656A (en) * | 2020-12-30 | 2021-04-13 | 宇肽生物(东莞)有限公司 | Polypeptide microneedle and preparation method thereof |
| CN113520905A (en) * | 2021-03-25 | 2021-10-22 | 甘肃天际生物科技有限公司 | Instant collagen microneedle and preparation method thereof |
| US20230414844A1 (en) * | 2022-06-24 | 2023-12-28 | Hangzhou Singclean Medical Products Co., Ltd | Cross-linked hydrogel microneedle for transdermal drug delivery and method for preparing the same |
| WO2024117132A1 (en) * | 2022-11-28 | 2024-06-06 | コスメディ製薬株式会社 | Collagen microneedle preparation |
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