CN104921961B - A kind of degradable biological microneedle patch of multiple-effect reparation - Google Patents
A kind of degradable biological microneedle patch of multiple-effect reparation Download PDFInfo
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- CN104921961B CN104921961B CN201510268825.6A CN201510268825A CN104921961B CN 104921961 B CN104921961 B CN 104921961B CN 201510268825 A CN201510268825 A CN 201510268825A CN 104921961 B CN104921961 B CN 104921961B
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- micropin
- beautifying liquid
- liquid coating
- coating
- microneedle array
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Abstract
The application is related to a kind of degradable biological microneedle patch of the multiple-effect reparation with different release gradients, and it has more preferable skin repair and cosmetic result, including substrate, and solid first microneedle array, the second microneedle array positioned at upper surface of substrate.First microneedle array has different beautifying liquid coatings from the second microneedle array so that the first microneedle array has different rate of release from the second microneedle array.First microneedle array includes some first micropins, and the second microneedle array includes some second micropins.First micropin, the second micropin include solid microneedles kernel.
Description
Technical field
The application is related to a kind of biological microneedle patch, in particular it relates to a kind of multiple-effect reparation with different release gradients
Degradable biological microneedle patch.
Background of invention
How human senescence is resisted, it is the eternal topic of beauty treatment fields skin is improved elastic, anti-aging.Human body occurs
During aging, skin of face can form wrinkle and color spot.Drug cosmetics and surgery beauty are two kinds of main intervention forms, but skin
Particularly cuticula has barrier action to Drug Percutaneous Absorption, and absorption of the skin to medicine, surgery are beautiful when hindering drug cosmetics
Container has the shortcomings that applicability is not wide, risk is high, complication and side effect are more, and drug cosmetics and surgery beauty usually can be by
Improper generation pain and spot are controlled or operate in dosage.In recent years, a kind of microneedle patch for beauty, or make a living
Thing microneedle patch is increasingly used by users, and this micropin has higher security and nonirritant.This biological microneedle patch
Generally comprise a substrate, multiple micropins in substrate and back of the body coating, apply on the micropin such as skin repair and
The material of beauty, or micropin directly is made in itself in the solid-like of these materials, micropin is gradually inhaled by human body in use
Receive.
The skin of human body has three-layer weave：Positioned at outermost cuticula, living Epidermis's layer and positioned at innermost corium
Layer.Cuticle thickness is about 30~50 microns, is made up of the horn cell of densification, its permeability to most medicines is very
Low, being these medicines passes through the major obstacle that percutaneously conveys；Skin layer thickness is about 50~100 microns, containing competent cell and
Minimal amount of nerve fiber, but there is no blood vessel；It is skin corium below epidermis, it is the chief component of skin, is contained
Substantial amounts of living cells, nerve fiber and vascular tissue.Conventional subcutaneous injection needs professional to be operated, and syringe needle external diameter is general
For 0.4~3.4 millimeter, syringe needle need to penetrate skin and be deep into muscle, can touch blood vessel and damage a large amount of nerve fibers, usually draw
Play patient's bleeding and pain.And use microneedle array, pressing apply pin by way of can moment in keratoderma and epidermis
Layer produces the duct of a large amount of micron dimension sizes, so as to significantly improve the permeability of medicine.Because micropin medicine-feeding part is in body surface
Nerve fiber and blood vessel are not touched, therefore will not produce pain and bleeding；In addition, need not be special using micropin administration
Industry personnel are operated, flexible and convenient to use, can interruption of the administration at any time, so being easier to be easily accepted by the patient.In addition, micropin pierces
The stratum corneum barrier for wearing skin produces the capillary network that microchannel makes medicine penetrate into dermal layer of the skin by micropin hole, with blood
The through treatment target position of liquid circulation, can reach and quickly and efficiently absorb the drug or the purpose of cosmetic material, at the same micropin stimulate it is true
Cortex, percutaneous self-healing ability promote ossein hyperplasia, and micropin can improve the absorptivity of medicine and reduce the wave of medicine
Take.Further, since micropin is thin and sharp, paracentesis depth does not contact nerve endings only in cuticula and dermis, therefore to body
The degree of injury of tissue reduces.
Micropin biology microneedle patch includes many different forms at present, soluble mainly including solid microneedles, empty micropin
Micropin.Wherein, solid microneedles are generally formed by polymer insoluble in skin, monocrystalline silicon and metal, and drug coat exists
Micropin outer surface；Empty micropin is that each micropin includes a passage, and applying medicine from substrate passes through passage target area on earth
Domain, empty micropin have the advantages of continuing, controllable drug delivery；Soluble micropin refers to that micropin is made up of medicine in itself, and biology is micro-
After pin patch is pressed on human body skin, micropin gradually dissolves, last only to peel off residual substrate layer from skin, has
The advantages that pain is small, easy to operate.
Specific to the biological microneedle patch for skin repair and beauty, it can be solid microneedles, and microneedle array surface applies
It is covered with skin repair and cosmetic material is pierced into skin again, or skin repair and beauty thing is applied again after microneedle array is pierced into skin
Matter.Microneedle array surface coats homogeneous skin repair and cosmetic material in the prior art, it is impossible to realizes heterogeneity material
Divide gradient release.
The content of the invention
The application provides a kind of degradable biological microneedle patch of the multiple-effect reparation with different release gradients, and it has more preferable
Skin repair and cosmetic result.
According to biological microneedle patch described herein, including substrate, and solid first micropin positioned at upper surface of substrate
Array, the second microneedle array and back of the body coating.First microneedle array has different beautifying liquid coatings from the second microneedle array, makes
Obtain the first microneedle array has different rate of release from the second microneedle array.First microneedle array includes some first micropins,
Second microneedle array includes some second micropins.First micropin, the second micropin include solid microneedles kernel.In an embodiment party
In formula, the back of the body coating of biological microneedle patch can play the bonding that cold compress effect and can strengthens biological paste and skin as adhered layer
Power.
The preparation method of solid microneedles is used more and directly prepared by semiconductor microactuator process technology, such as reactive ion beam etching (RIBE)
(RIE), focused-ion-beam lithography (FIB), micro- casting etc. are low.Material may be selected from metal, ceramics, the macromolecule material of biocompatibility
Material etc..
The arrangement of first microneedle array, the second microneedle array can arbitrarily be set as needed, for example, independent first micropin with
It is arranged at intervals between second micropin, or the first micropin, the second micropin are arranged in column, each micropin of row first and each row second are micro-
Pin is arranged at intervals, or the first micropin, the second micropin lopping arrangement, and each first micropin that encloses is arranged at intervals with the second micropin of each circle.
In one embodiment, the first micropin and the second micropin only include one layer of beautifying liquid coating, but the first micropin
Beautifying liquid coating it is different from the beautifying liquid coating of the second micropin, there is different rate of release.
In another embodiment, the first micropin includes two layers of beautifying liquid coating, respectively undercoating and external coating, the
Two micropins only include one layer of beautifying liquid coating, and second micro- beautifying liquid coating can be with wherein one layer of beautifying liquid coating of the first micropin
Composition is identical.The external coating of first micropin can coat the material that such as skin quickly absorbs, such as noncrosslinking hyaluronic acid, and
Undercoating may be selected other cosmetic materials, for example, the hyaluronic acid of crosslinking, fat stem cell, EGF, chestnut stoste,
Rice bran stoste, Chinese yam stoste etc.；Deng.
Beautifying liquid coating material can be hyaluronic acid, or be the mixture of PVA and hyaluronic acid to realize hydrophily
The percutaneous controlled-release of macromolecular such as albumen, polypeptide, DNA, RNA and other drugs.
Prior art fully proves：Hyaluronic acid has moisturizing, maintenance and trophism to skin, and it can be pinned greatly
Measure hydrone, skin is kept full high resilience, reduce wrinkle, can also mild dilation capillary, increase blood circulation, change
Kind intermediate supersession, promotes the absorption of skin-nourishing and the discharge of waste, and hyaluronic acid is good transdermal again while moisturizing
Sorbefacient.The non-crosslinked hyaluronic acid of the dalton of 30K~4000000, preferably 500~2000000 dalton is non-crosslinked
Micropin intensity made of hyaluronic acid is high, and absorption efficiency is high, soak time is lasting.
It is the non-crosslinked hyaluronic acid of the dalton of 30K~3000000 or is mixed with more specifically, coating material is molecular weight
The hyaluronic acid or cross-linked-hyaluronic acid of different molecular weight, cross-linked-hyaluronic acid can be natural cross-linked-hyaluronic acids, or
With the hyaluronic acid of BDDE crosslinking.It is demonstrated experimentally that molecular weight is the dalton of 30K~3000000
Micropin intensity made of non-crosslinked hyaluronic acid is high, and mixing the hyaluronic acid of different molecular weight, not only further to improve micropin strong
Degree, and be easy to dissolving in skin, degradation speed is slow in skin so that cosmetic result is more preferable, more longlasting.
Active component can be added in coating material：Skin moisturizer, such as glycerine or filaggrin；Beneficial to skin
The vigor and nutriment of reparation, such as：Stem cell, EGF, vitamin C, vitamin A or vitamin E, chestnut are former
Liquid, rice bran stoste, Chinese yam stoste etc.；Skin-whitening agents, such as：Hydroquinones, ursin, kojic acid, hydroxyacetic acid or niacinamide
Deng.
In a detailed embodiment, coating material is that molecular weight is the non-crosslinked transparent of the dalton of 30K~3000000
Matter is sour, natural cross-linked-hyaluronic acid, stem cell, EGF, vitamin E, hydroquinones.
Stem cell is a kind of multipotential cell with self-renewing, infinite copy and Multidirectional Differentiation ability, and medical field claims
For " general-purpose cell ".Wherein, fat stem cell has extremely strong in-vitro multiplication ability, can be to fat, bone, muscle, endothelium, pancreas
The cell such as island, nerve direction breaks up.Compared with other stem cells, there is fat stem cell biological characteristics to stablize, source is sufficient,
The advantages such as easy acquisition and condition of in vitro culture are simple.Fat stem cell can with secrete cytokines and growth factor, play nutrition,
The function of the senile cell of body injury is repaired and replaced, antioxidant, scavenging activated oxygen, heat shock protein can also be provided
To part, local toxicity material is eliminated, promotes cell and tissue repair, in addition, fat stem cell can increase collagen egg
White secretion, swallows pigment removal color spot, improves skin elasticity, therefore fat stem cell has extraordinary crease-resistant, nti-freckle effect
Fruit.
EGF, which can promote cytotrophy material to be transported to from extracellular active, into the cell, increases intracellular battalion
Support.Promote corium confluent monolayer cells secretion synthesis collagenous fibres, make dermal tissue full, so as to reduce and smooth away wrinkles.In addition, epidermis
Growth factor has the accumulation such as stronger facilitation, and residual of less pigment and dead cell to the propagation of epidermal cell,
Color spot and pigmentation are eliminated, goes out cutaneous manifestations tender white.Therefore, EGF, which also has, smoothes away wrinkles and prevents color spot
Effect.
Chestnut stoste contains the nutriments such as carbohydrate, starch, protein, fat, vitamin B1 and B2, according to《Compendium of Materia Medica》
Record：Chestnut " it is smash scattered, and sweet painting face, make light suddenly remove wrinkle ".
Rice bran stoste, which helps skin, becomes that water is tender, bright, and long-term use can be with skin whitening, can be with decontamination for having one's hair wash
Maintaining hair simultaneously.Shown according to modern study, abundant vitamin A, B1, B2, C, E, amino acid and nicotinic acid etc. are contained in rice bran
It nutriment needed for skin, can stimulate circulation, accelerate the metabolism of Skin Cell.In addition, also containing rich in rice bran
Rich cytotrophy composition and the bioactie agent of multiple functions, can delaying skin aging.Can be to spot, wrinkle, coarse, dark sore
Or the skin of surface moisture deficiency is effectively improved.Also there is the function of moisturizing, can effectively prevent scaly dry skin, delaying skin
Aging, the effect for preventing pigment deposition；According to《Japanese agriculture news》In report, Korean and Japanese university's young scientist Yamamoto great generation, use old
The comparative experiments result that mouse is carried out shows that the effect that the ceramide glucoside extracted from rice bran suppresses melanin generation is
29%, 39% than the kojic acid with same effect is slightly lower.Yamamoto is said, compared with other materials, ceramide glucoside is
A kind of safer cosmetic material, because it does not contain the toxin of the cell of attack manufacture pigment, while it can also mitigate ultraviolet
Injury of the line to skin.So skin wet, fair and clear can be made.
The external coating of first micropin is also an option that non-beautifying liquid coating, such as controlled-release coating, preferably bioabsorbable
Medical grade substance, its dissolution velocity in skin is slower than the dissolution velocity of above-mentioned coating material, micro- for example with porous silicon
Particle shape into silicon coating, or use bioabsorbable polymer, such as poly- DL- lactides, polylactide -co- second third hands over
Ester；Polylactide -co- polycaprolactone, poly- (L- lactide-cos -1,3-PD carbonic ester), poly- 1,3-PD carbonic ester
And copolymer；Poly butyric ester and copolymer；Poly- hydroxyl valerate and copolymer；Poe and copolymer；Polyanhydride and altogether
Polymers；Poly- iminocarbonic ester and copolymer.
When using the biological microneedle patch of the application, first the skin of target area is cleaned, dried, then by the application's
Back of the body coating in biological paste is entirely attached on human body skin after being affixed on microneedle substrate face, is carried on the back coating by finger pressure micropin, is made micro-
It is different with different rate of release and/or release that pin array is pierced into human body skin, the first microneedle array and the second microneedle array B
Cosmetic material, so as to realize a point gradient release active ingredient.
Brief description of the drawings
Fig. 1：According to the front view of biological microneedle patch described herein；
Fig. 2：According to the top view of biological microneedle patch described herein；
Fig. 3：The zoomed-in view of first micropin；
Fig. 4：The zoomed-in view of second micropin.
Embodiment
Referring to accompanying drawing 1,2, according to the degradable biological microneedle patch of multiple-effect reparation described herein, including substrate 1, and
Positioned at the solid first microneedle array A of the upper surface of substrate 1, the second microneedle array B, back of the body coating 1 '.Microneedle array A and microneedle array
B has different beautifying liquid coatings so that the first microneedle array A has different rate of release from the second microneedle array B.Micropin
Array A includes some first micropin a, and microneedle array B includes some second micropin b.Micropin a, micropin b include in solid microneedles
Core 2.In one embodiment, the back of the body coating in biological microneedle patch can play cold compress effect and can as adhered layer and strengthen giving birth to
Thing pastes the bonding force with skin.
The preparation method of solid microneedles is used more and directly prepared by semiconductor microactuator process technology, such as reactive ion beam etching (RIBE)
(RIE), focused-ion-beam lithography (FIB), micro- casting etc. are low.Material may be selected from metal, ceramics, the macromolecule material of biocompatibility
Material etc..
Microneedle array A, microneedle array B arrangement can arbitrarily be set as needed, such as independent first micropin and second micro-
It is arranged at intervals between pin, or micropin a, micropin b arrange in column, each row micropin a and each row micropin b is arranged at intervals, Huo Zhewei
Pin a, micropin b lopping arrangement, each micropin a and each circle micropin b that encloses are arranged at intervals.
In one embodiment, micropin a and micropin b only includes one layer of beautifying liquid coating, but micropin a beautifying liquid applies
Layer is different from micropin b beautifying liquid coating, has different rate of release.
In another embodiment, micropin a includes two layers of beautifying liquid coating, and micropin b only includes one layer of beautifying liquid coating,
Micropin b beautifying liquid coating can be identical with micropin a wherein one layer of beautifying liquid coating composition.For example, as shown in Figure 3,4, micropin a
Including kernel 2, undercoating 4, external coating 3, micropin b includes kernel 2, the composition identical coating 4 of undercoating 4 with micropin a.At this
In embodiment, due to micropin a more than micropin b an external coating 3, its rate of release is such as slower than micropin b, and external coating 3 can apply
Cover the material that such as skin quickly absorbs, such as noncrosslinking hyaluronic acid.And other cosmetic materials may be selected in undercoating 4, example
Hyaluronic acid, fat stem cell, the EGF of such as crosslinking.
As embodiment is replaced, micropin a external coating is identical with micropin b coating.
Beautifying liquid coating material can be hyaluronic acid, or be the mixture of PVA and hyaluronic acid to realize hydrophily
The percutaneous controlled-release of macromolecular such as albumen, polypeptide, DNA, RNA and other drugs.
It is the non-crosslinked hyaluronic acid of the dalton of 30K~3000000 or is mixed with more specifically, coating material is molecular weight
The hyaluronic acid or cross-linked-hyaluronic acid of different molecular weight, cross-linked-hyaluronic acid can be natural cross-linked-hyaluronic acids, or
With the hyaluronic acid of BDDE crosslinking.It is demonstrated experimentally that molecular weight is the dalton of 30K~3000000
Micropin intensity made of non-crosslinked hyaluronic acid is high, and mixing the hyaluronic acid of different molecular weight, not only further to improve micropin strong
Degree, and be easy to dissolving in skin, degradation speed is slow in skin so that cosmetic result is more preferable, more longlasting.
Active component can be added in coating material：Skin moisturizer, such as glycerine or filaggrin；Beneficial to skin
The vigor and nutriment of reparation, such as：Stem cell, EGF, vitamin C, vitamin A or vitamin E, chestnut are former
Liquid, rice bran stoste, Chinese yam stoste etc.；Skin-whitening agents, such as：Hydroquinones, ursin, kojic acid, hydroxyacetic acid or niacinamide
Deng.
In a detailed embodiment, coating material is that molecular weight is the non-crosslinked transparent of the dalton of 30K~3000000
Matter is sour, natural cross-linked-hyaluronic acid, stem cell, EGF, vitamin E, hydroquinones.
Micropin a external coating is also an option that non-beautifying liquid coating, such as controlled-release coating, and preferably bioabsorbable is medical
Level material, its dissolution velocity in skin is slower than the dissolution velocity of above-mentioned coating material, for example with porous silicon particle shape
Into silicon coating, or use bioabsorbable polymer, such as poly- DL- lactides, polylactide -co- second lactide；
Polylactide -co- polycaprolactone, poly- (L- lactide-cos -1,3-PD carbonic ester), poly- 1,3-PD carbonic ester and
Copolymer；Poly butyric ester and copolymer；Poly- hydroxyl valerate and copolymer；Poe and copolymer；Polyanhydride and copolymerization
Thing；Poly- iminocarbonic ester and copolymer.
When using the biological microneedle patch of the application, first the skin of target area is cleaned, dried, then by the application's
Biological microneedle patch back of the body coating is entirely attached on human body skin after being affixed on microneedle substrate face, is carried on the back coating by finger pressure micropin, is made micro-
Pin array is pierced into human body skin, microneedle array A and microneedle array B with the different beauty thing of different rate of release and/or release
Matter, so as to realize a point gradient release active ingredient.
Claims (8)
1. a kind of degradable biological microneedle patch of the multiple-effect reparation with different release gradients, including substrate, and positioned at substrate
Solid first microneedle array of upper surface, solid second microneedle array and back of the body coating, the back of the body coating of wherein biological paste can rise
Strengthen the bonding force of biological paste and skin as adhered layer to cold compress effect and can, it is characterised in that：
First microneedle array has different beautifying liquid coatings from the second microneedle array so that the first microneedle array and the second micropin
Array has different rate of release；First microneedle array includes some first micropins, and the second microneedle array includes some second
Micropin, the first micropin, the second micropin include solid microneedles kernel；
It is arranged at intervals between wherein independent first micropin and independent second micropin, or the first micropin, the second micropin are in column
Arrangement, each micropin of row first and each micropin of row second are arranged at intervals, or the first micropin, the second micropin lopping arrangement, respectively enclose the
One micropin is arranged at intervals with the second micropin of each circle；
First micropin includes two layers of beautifying liquid coating, and second micropin only includes one layer of beautifying liquid coating, and described second
The beautifying liquid coating of micropin is identical with wherein one layer of beautifying liquid coating composition of the first micropin, because the first micropin is than the second micropin
More one layer of external coating, its rate of release is slower than the second micropin, the material that the external coating coating skin of the first micropin quickly absorbs, interior
Coating selects other cosmetic materials.
2. the degradable biological microneedle patch of multiple-effect reparation according to claim 1, wherein the first micropin and the second micropin are equal
One layer of beautifying liquid coating is only included, but the beautifying liquid coating of the first micropin is different from the beautifying liquid coating of the second micropin, has not
Same rate of release.
3. the degradable biological microneedle patch of multiple-effect reparation according to claim 1, wherein the first micropin includes two layers of beauty
Liquid coating, respectively undercoating and external coating, the second micropin only include one layer of beautifying liquid coating, the beautifying liquid coating of the second micropin
It is identical with wherein one layer of beautifying liquid coating composition of the first micropin.
4. the degradable biological microneedle patch of the multiple-effect reparation according to any one of claim 1-3, wherein beautifying liquid coating
For the non-crosslinked hyaluronic acid of the dalton of 30K~4000000.
5. the degradable biological microneedle patch of the multiple-effect reparation according to claim 1-3, wherein beautifying liquid coating be 500~
The non-crosslinked hyaluronic acid of 2000000 dalton.
6. the degradable biological microneedle patch of multiple-effect reparation according to claim 5, wherein beautifying liquid coating are different molecular
The mixture of the non-crosslinked hyaluronic acid of 500~2000000 dalton of amount.
7. the degradable biological microneedle patch of multiple-effect reparation according to claim 6, wherein beautifying liquid coating also include crosslinking
Hyaluronic acid.
8. the degradable biological microneedle patch of multiple-effect reparation according to claim 7, wherein beautifying liquid coating also include fat
Stem cell, EGF, vitamin E, hydroquinones, chestnut stoste, rice bran stoste, Chinese yam stoste.
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Families Citing this family (6)
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| CN105944226A (en) * | 2016-03-09 | 2016-09-21 | 陈彦彪 | Degradable supermicro needle for inoculated eyebrows and inoculated eyelashes and preparing method thereof |
| US11013670B2 (en) | 2016-06-16 | 2021-05-25 | Endoderma Co., Ltd. | Hyaluronic acid microstructure having excellent solubility characteristics |
| JP6858447B2 (en) * | 2017-03-27 | 2021-04-14 | Ｎｉｓｓｈａ株式会社 | Microneedle sheet |
| CN108721204A (en) * | 2018-06-04 | 2018-11-02 | 南京紫源康医药科技有限公司 | A kind of solubility alkannin microneedle patch and preparation method thereof |
| CN111218013B (en) * | 2020-01-22 | 2022-08-23 | 上海应用技术大学 | Preparation method and application of crosslinked polymer |
| CN114146046B (en) * | 2020-09-07 | 2024-03-01 | 中国科学院理化技术研究所 | Coated microneedle with multilayer structure, preparation method thereof and microneedle patch comprising coated microneedle |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101330941A (en) * | 2006-07-21 | 2008-12-24 | 延世大学工业学术合作社 | A solid type microneedle and methods for preparing it |
| CN103301563A (en) * | 2013-06-20 | 2013-09-18 | 吴传斌 | Soluble coaxial-cone multi-layer microneedle, microneedle array and preparation method of microneedle |
| CN104095761A (en) * | 2013-04-08 | 2014-10-15 | 上海汇林医药科技有限公司 | Polymer microneedle patch and application thereof |
| CN104379020A (en) * | 2012-06-29 | 2015-02-25 | Elc管理有限责任公司 | Microneedles comprising one or more cosmetic ingredients |
Family Cites Families (2)
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|---|---|---|---|---|
| JP5572310B2 (en) * | 2008-12-19 | 2014-08-13 | 凸版印刷株式会社 | Manufacturing method of needle-shaped body |
| US20120027837A1 (en) * | 2010-07-27 | 2012-02-02 | Massachusetts Institute Of Technology | Multilayer coating compositions, coated substrates and methods thereof |
-
2015
- 2015-05-25 CN CN201510268825.6A patent/CN104921961B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101330941A (en) * | 2006-07-21 | 2008-12-24 | 延世大学工业学术合作社 | A solid type microneedle and methods for preparing it |
| CN104379020A (en) * | 2012-06-29 | 2015-02-25 | Elc管理有限责任公司 | Microneedles comprising one or more cosmetic ingredients |
| CN104095761A (en) * | 2013-04-08 | 2014-10-15 | 上海汇林医药科技有限公司 | Polymer microneedle patch and application thereof |
| CN103301563A (en) * | 2013-06-20 | 2013-09-18 | 吴传斌 | Soluble coaxial-cone multi-layer microneedle, microneedle array and preparation method of microneedle |
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