CN108014413A - Soluble micropin introducing apparatus and its application method - Google Patents
Soluble micropin introducing apparatus and its application method Download PDFInfo
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- CN108014413A CN108014413A CN201711361424.0A CN201711361424A CN108014413A CN 108014413 A CN108014413 A CN 108014413A CN 201711361424 A CN201711361424 A CN 201711361424A CN 108014413 A CN108014413 A CN 108014413A
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- micropin
- skin
- soluble
- patch
- introducing apparatus
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Abstract
The invention discloses a kind of soluble micropin introducing apparatus, including handle, connecting portion and acupuncture portion, the acupuncture portion is planar structure, arc-shaped curved surface structure or the roller of corresponding human body different parts skin, patch is adsorbed with the acupuncture portion, some soluble micropins are bonded with the patch, soluble micropin is pierced into skin by the acupuncture portion by pressing or rolling around pressing up and down.The invention also discloses three kinds of soluble micropin introducing apparatus application methods.This introducing apparatus and its application method are using soluble micropin, dissolving can occur directly in skin and smear functional cosmetics or medicine again after release function cosmetics or active constituents of medicine or the multiple fine conduction pathways of manufacture, the absorption efficiency of deep skin is very high, prevent from being similar to solid micropin fracture undissolved situation in skin, it is very safe, injury is not produced to skin, and patch is disposable, prevents cross-infection.
Description
Technical field
The present invention relates to medicine and beauty treatment fields, more particularly to soluble micropin to import equipment.
Background technology
How medicine correctly imported into therapentic part so that it is that medical domain faces that medicine, which plays effect and maximizes,
New problem.Beauty circle is also faced with the problem of same, particularly how effectively to import active ingredient to skin in skin surface
Epidermis and skin corium, become a great problem of beauty circle.
Cuticula is the most firm protective layer of skin surface so that the active ingredient or battalion that general utility functions cosmetics are rich in
Foster material cannot go directly skin base layer the main reason for.General beauty apparatus many on the market are all the beauty apparatus such as ultrasonic wave
Attempt to strengthen and expand nutriment and pass through the ability of cuticula, but effect unobvious, and long-time service can cause pore thick
The negative effect such as big.Epidermis is artificially removed also by technologies such as pickling, laser so that the skin corium weight below epidermal tissue
Brand-new epidermal tissue is newly differentiated, to realize skin gloss whitening effect.But using during the therapeutic modality due to skin
It is longer that skin recovers the cycle, remove old epidermal tissue and during new epidermal tissue not yet grows, skin be easy to by
Trigger skin disease to bacterium infection；On the other hand, epidermis is removed commonly using this method, thinning of skin can be caused to skin
Skin health has a negative impact.
At present, the painless percutaneous dosing of micropin can be created painlessly micro- on the skin as a kind of new medicine-feeding technology
The drug delivery passage of meter level, strengthens permeability of the skin to active material or medicine especially macromolecular drug, because it has
The advantage such as painless, safe, easy to operate, represent future drugs percutaneously to the developing direction conducted in vivo.
Solid micropin is widely used in beauty treatment fields, can manufacture many micro-channels in skin layer, smear traditional work(afterwards
Energy property cosmetics so that active ingredient can be transmitted to deep skin and improve absorption efficiency.But solid microneedle configuration, material and system
The problems such as making method brings unfavorable factor, such as, 1 to consumer) cost of manufacture height：Solid micropin largely uses laser at present
Engraving mode, causes manufacturing expense higher；2) security：The metal and monocrystalline silicon micropin that existing market occurs, because of micropin in itself
The small structure having causes its intensity relatively low, it is easy to the hidden danger in micropin fracture skin occurs；3) it is also easy to produce cross-infection：
For solid-state micropin because expensive, general application method sterilizes incomplete or cross-utilization to be recycled after disinfection,
The problems such as being easy to cause skin infection.
The content of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides soluble micropin introducing apparatus and three kinds of solubilities are micro-
Soluble micropin, under the premise that security is guaranteed, more effectively can accurately be pierced into skin, make by pin introducing apparatus application method
The Transdermal absorption efficiency for obtaining functional cosmetics or active constituents of medicine maximizes, and reduces cost.
The technical solution adopted by the present invention to solve the technical problems is：
Soluble micropin introducing apparatus, including handle, connecting portion and acupuncture portion, the acupuncture portion are corresponding human body different parts
Planar structure, arc-shaped curved surface structure or the roller of skin, are adsorbed with patch in the acupuncture portion, are bonded with the patch some
Soluble micropin is pierced into skin by soluble micropin, the acupuncture portion by pressing or rolling around pressing up and down.
As the improvement of above-mentioned technical proposal, the acupuncture portion includes some elastic silica gels protrusions for being arranged in its surface,
The patch absorption is in elastic silica gel protrusion.
As the improvement of above-mentioned technical proposal, the solubility micropin is soluble high-molecular material.
As the improvement of above-mentioned technical proposal, the solubility micropin diameter reduces along its length or vertical section is in arrow
Type.
As the improvement of above-mentioned technical proposal, it is described solubility micropin in be equipped with functional cosmetics or pharmaceutical activity into
Point.
Soluble micropin introducing apparatus application method, this method include：According to skin surface, corresponding acupuncture is selected
Portion, wherein, soluble micropin diameter reduces along its length；Extract in skin surface repeated action solubility micropin and finally,
Skin surface is set to manufacture multiple fine conduction pathways；Before conduction pathway is manufactured or after having manufactured conduction pathway, in skin
Functional cosmetics or active constituents of medicine are smeared on surface so that functional cosmetics or active constituents of medicine are logical by conducting
Road enters deep skin, if the soluble micropin fracture in part, in skin, which dissolves in skin.
Soluble micropin introducing apparatus application method, this method include：
Step 1: according to skin surface, corresponding acupuncture portion is selected, wherein, soluble micropin diameter is along length side
To reduction, functional cosmetics or active constituents of medicine are equipped with soluble micropin, it is viscous between soluble micropin and patch
Property be more than adsorption capacity between acupuncture portion and patch；
Step 2: acting on soluble micropin in skin surface, after soluble micropin is pierced into skin, patch substrate is adhered to skin
Skin surface, patch depart from naturally with acupuncture portion；
Step 3: treat that dissolving and release function cosmetics or active constituents of medicine occur in skin for soluble micropin,
Tear patch.
Soluble micropin introducing apparatus application method, this method include：
Step 1: according to skin surface, corresponding acupuncture portion is selected, wherein, soluble micropin vertical section is in arrow
Type, is equipped with functional cosmetics or active constituents of medicine in soluble micropin, sticky small between soluble micropin and patch
Adsorption capacity between acupuncture portion and patch；
Step 2: acting on soluble micropin in skin surface, after soluble micropin is pierced into skin, soluble micropin is embedded in
Separated in skin and with patch；
Step 3: dissolving and release function cosmetics or active constituents of medicine occur in skin for soluble micropin.
As the improvement of above-mentioned technical proposal, step 4 is further included：Functional cosmetics or medicine are smeared in skin surface
Active ingredient is conducted with carrying out various medicine.
Beneficial effects of the present invention have：
This introducing apparatus and its application method connect handle, acupuncture portion is directed to human body using soluble micropin in acupuncture portion
Joint curved portion selects roller, and by selecting planar structure for belly or buttocks, arc-shaped curved surface structure is selected for face,
Soluble micropin on patch is pierced into skin by acupuncture portion by pressing or rolling around pressing up and down, can be directly in skin
Dissolving occurs and smears work(again after release function cosmetics or active constituents of medicine or the multiple fine conduction pathways of manufacture
Energy property cosmetics or medicine, the absorption efficiency of deep skin is very high, prevents from being broken similar to solid micropin insoluble in skin
The situation of solution, it is very safe, injury is not produced to skin, and patch is disposable, prevents cross-infection.
Brief description of the drawings
Below in conjunction with the accompanying drawings and specific embodiment the invention will be further described, wherein：
Fig. 1 is the structure diagram of first embodiment of the invention；
Fig. 2 is the structure diagram of fourth embodiment of the invention；
Fig. 3 is the part-structure schematic diagram of second embodiment of the invention；
Fig. 4 is the part-structure schematic diagram of third embodiment of the invention；
Fig. 5 a~5c are the schematic diagrames of the first application method in the present invention；
Fig. 6 a~6c are the schematic diagrames of second of application method in the present invention；
Fig. 7 a~7c are the schematic diagrames of the third application method in the present invention.
Embodiment
Referring to Fig. 1, Fig. 3 and Fig. 4, soluble micropin introducing apparatus of the invention, including handle 1, connecting portion 2 and acupuncture portion 3,
The handle is matched, connecting portion 2 is used to connect handle 1 using the shape for meeting ergonomic designs with the palm curved surface of people
With acupuncture portion 3, using elasticity, plug-in type or card slot type structure, in the present embodiment, connecting portion 2 uses elastic construction, built-in spring
21, the acupuncture portion 3 is planar structure 31, arc-shaped curved surface structure 32 or the roller 33 of corresponding human body different parts skin, is formed
The present invention first, second, and third embodiment, acupuncture portion 3 for human synovial curved portion select roller 33, by for
Belly or buttocks selection planar structure 31, are specially tablet, for face's selection arc-shaped curved surface structure 32.
With further reference to Fig. 2, the acupuncture portion 3 includes some elastic silica gel protrusions 301 for being arranged in its surface, flexible silicon
The height of glue protrusion 301 is 1 μm~5mm, a diameter of 0.01 μm~50 μm, in 1mm2More than at least ten elasticity is included in area
Silica gel protrusion 301, forms the adhesive surface of imitated gecko sole so that and patch 4 is effectively adsorbed in elastic silica gel protrusion 301,
The present invention is not limited to arrangement elastic silica gel protrusion, other adhesive patches and physical adsorption way in acupuncture portion 3, described
Patch 4 is adsorbed with acupuncture portion 3, some soluble micropins 5 are bonded with the patch 4,5 diameter of solubility micropin edge is long
Spend that direction reduces or vertical section is in arrowhead-shaped, concretely taper, pyramid, bullet shaped or rocket-shaped；Can also be to use
Vertical section is in arrowhead-shaped geometrical combination body, such as the combination of the combination of cone and cylinder, pyramid and cylinder, is possessed
Back-off structure, is not drawn out easily after being pierced into skin.As depicted in figs. 1 and 2, the acupuncture portion 3 by pressing or rolling around up and down
Soluble micropin 5 is pierced into skin 6 by pressing.
Wherein, the soluble micropin 5 is soluble high-molecular material, has higher hardness, tensile strength and ductility,
Concretely polyester, PHA, poly- ('alpha '-hydroxy acids), poly- (beta-hydroxy acid), PHBV, PHP, PHH, PHA-PEG, poly- (4- carboxylic acids),
Poly- ('alpha '-hydroxy acids), poly- (beta-hydroxy acid), poly- (4 hydroxybutyric acid ester), poly- (4- hydroxyl valerates), poly- (diethoxalic acid ester),
Poly- (esteramides), pla-pcl, polylactide, polyglycolide, PLGA, 15- polydioxanone, polyorthoester, polyether ester,
Polyanhydride, poly- (glycolic -co- trimethylene carbonate), polyphosphate, polyphosphate carbamate, poly- (amino acid), paracyanogen
Base acrylate, poly(trimethylene carbonate), poly- (iminocarbonic ester), poly- (tyrosine carbonic ester), makrolon, poly-
(tyrosine aryl ester), polyalkylenes oxalates, polyphosphoric acid creatine, PHA-PEG, chitosan, dextran, cellulose, heparin,
Hyaluronic acid, alginic acid, synanthrin, starch or glycogen, above-mentioned material can be used alone, and can also be used in mixed way.
In addition, functional cosmetics or active constituents of medicine can be also carried in the solubility micropin 5, when soluble micropin
Dissolve, can be used in the present invention in release function cosmetics or active constituents of medicine to skin in skin
Medicine is not particularly limited, for example, medicine can include chemicals, protein drug, peptide medicine, gene therapy nucleic acid molecules
With nano particle etc..The medicine that can be used in the present invention can include：Antiinflammatory, analgestic, Antiarthritic agent, Anticonvulsants,
Antidepressants, major tranquilizer, nerous sedative, antianxiety agent, narcotic antagonist, antiparkinsonism drug, cholinergic agonist,
Anticancer, anti-angiogenic agent, immunodepressant, antivirotic, antibiotic agent, amfetamine, anodyne, anticholinergic
Agent, antihistaminic, anti-migraine agent, hormone drug, coronary vasodilation agent, cerebral blood vessel diastole agent or peripheral vasodilation
Agent, contraceptive, antithrombotic agents, diuretics, rescinnamine, cardiovascular disease and Remedies, but used medicine is not limited to
This.
The cosmetic functional component that soluble micropin is carried can include moisturizer, such as glycerine, intermediate filament correlation egg
It is white etc.；Can also be the material with wrinkle, such as hyaluronic acid (non-crosslinked, crosslinking)；Also can also be whitening agent, such as
Hydroquinone, ursin, kojic acid, hydroxyacetic acid or niacinamide etc.；It can also be that skin rejuvenates material：As vitamin C,
VitAVitE etc.；Either anti-acne medicine, as Madecassoside (madecassoside),
Epigallocatechin Gallate (-)-catechin acid esters, Salicylates, 2-hydroxybenzoic, Salicylic
Acid, Beta Hydroxy Acid (salicylic acid, salicylic acid, B skin softenings acid) etc..
The present invention also provides the application method of the above-mentioned soluble micropin introducing apparatus of three kinds of uses, wherein：
Referring to Fig. 5 a~5c, the first soluble micropin introducing apparatus application method includes：
Step 1: according to 6 surface configuration of skin, corresponding acupuncture portion 3 is selected, wherein, soluble 5 diameter of micropin is along length
Direction reduces；
Step 2: extracting in skin surface repeated action solubility micropin and finally, make skin surface manufacture multiple fine
Conduction pathway 7；
Step 3: smear functional cosmetics or active constituents of medicine on a skin surface so that functional cosmetics or
Active constituents of medicine enters deep skin by conduction pathway 7.
Wherein, in step 2, if the soluble micropin 5 in part is broken in skin, the part solubility micropin 5 is in skin
It is interior to dissolve, skin will not be produced and endangered, in the present embodiment, acupuncture portion 3 selects planar structure 31, patch 4 and solubility
Micropin 5 is disposable, without recycling, prevents cross-infection, in addition step 2 and step 3 can exchange, Ke Yixian
Functional cosmetics or active constituents of medicine are smeared, remanufactures conduction pathway 7, functional cosmetics or active constituents of medicine also can
Enter deep skin from conduction pathway 7.
Referring to Fig. 6 a~6c, second of soluble micropin introducing apparatus application method includes：
Step 1: according to skin surface, corresponding acupuncture portion 3 is selected, wherein, soluble 5 diameter of micropin is along length
Direction reduces, and functional cosmetics or active constituents of medicine is equipped with soluble micropin, between soluble micropin 5 and patch 4
Viscosity be more than adsorption capacity between acupuncture portion and patch 4；
Step 2: in 6 surface action solubility micropin 5 of skin, after soluble micropin 5 is pierced into skin, the adhesion of 4 substrate of patch
In skin surface, patch 4 departs from naturally with acupuncture portion 3；
Step 3: treat that dissolving and release function cosmetics or active constituents of medicine occur in skin for soluble micropin,
Tear patch 4.
This application method benefits from the elastic silica gel protrusion 301 on 3 surface of acupuncture portion, forms the bonding of imitated gecko sole
Patch 4 can easily be adsorbed beneficial to separation in face, acupuncture portion 3, and the mode that soluble micropin 5 directly dissolves in skin causes can
The medicine conduction efficiency of dissolubility micropin greatly improves.
Referring to Fig. 7 a~7c, the third soluble micropin introducing apparatus application method, this method includes：
Step 1: according to skin surface, corresponding acupuncture portion 3 is selected, wherein, soluble 5 vertical section of micropin is in arrow
Head dummy, is equipped with functional cosmetics or active constituents of medicine in soluble micropin 5, viscous between soluble micropin 5 and patch 4
Property be less than adsorption capacity between acupuncture portion and patch；
Step 2: in 6 surface action solubility micropin 5 of skin, after soluble micropin 5 is pierced into skin, soluble micropin 5 is embedding
Enter in skin and separated with patch 4；
Step 3: dissolving and release function cosmetics or active constituents of medicine occur in skin for soluble micropin 5.
In addition, further include step 4：It is various to carry out in 6 surface smear functional cosmetics of skin or active constituents of medicine
Medicine conduction, it is contemplated that for a long time skin surface paste patch user can be made not feel well, this application method utilize and arrow
The mode that the soluble micropin of type is combined, it is arrowhead-shaped to be influenced by its back-off, it is not drawn out easily after being inserted into skin, makes its suffered resistance
More than the viscosity between soluble micropin 5 and patch 4, achieve the purpose that soluble micropin 5 is easily broken with patch 4, so that nothing
Patch long-term adhesion is needed preferably to improve user's use feeling and comfort level in skin surface.
The better embodiment of the above, the simply present invention, but the present invention is not limited to above-described embodiment, as long as
It reaches the technique effect of the present invention with any same or similar means, should all belong to protection scope of the present invention.
Claims (10)
1. soluble micropin introducing apparatus, it is characterised in that：Including handle, connecting portion and acupuncture portion, the acupuncture portion is corresponding people
Planar structure, arc-shaped curved surface structure or the roller of body different parts skin, are adsorbed with patch in the acupuncture portion, on the patch
Some soluble micropins are bonded with, soluble micropin is pierced into skin by the acupuncture portion by pressing or rolling around pressing up and down
It is interior.
2. solubility micropin introducing apparatus according to claim 1, it is characterised in that：The acupuncture portion includes some be arranged in
The elastic silica gel on its surface is raised, and the patch absorption is in elastic silica gel protrusion.
3. solubility micropin introducing apparatus according to claim 1, it is characterised in that：The solubility micropin is soluble high
Molecular material.
4. solubility micropin introducing apparatus according to claim 3, it is characterised in that：The solubility micropin diameter is along length
Direction reduces or vertical section is in arrowhead-shaped.
5. solubility micropin introducing apparatus according to claim 3, it is characterised in that：Carried in the solubility micropin active
Can property cosmetics or active constituents of medicine.
6. soluble micropin introducing apparatus application method, it is characterised in that：The method is using described in any one of Claims 1 to 4
Soluble micropin introducing apparatus, this method includes：According to skin surface, corresponding acupuncture portion is selected, wherein, it is soluble micro-
Pin diameter reduces along its length；Extract in skin surface repeated action solubility micropin and finally, make skin surface manufacture more
A fine conduction pathway；Before conduction pathway is manufactured or after having manufactured conduction pathway, feature is smeared on a skin surface
Cosmetics or active constituents of medicine so that functional cosmetics or active constituents of medicine enter deep skin by conduction pathway.
7. solubility micropin introducing apparatus application method according to claim 6, it is characterised in that：If the soluble micropin in part
In skin, which dissolves in skin for fracture.
8. soluble micropin introducing apparatus application method, it is characterised in that：The method is using described in any one of Claims 1 to 4
Soluble micropin introducing apparatus, this method includes：
Step 1: according to skin surface, corresponding acupuncture portion is selected, wherein, soluble micropin diameter subtracts along its length
It is small, functional cosmetics or active constituents of medicine are equipped with soluble micropin, the viscosity between soluble micropin and patch is big
Adsorption capacity between acupuncture portion and patch；
Step 2: acting on soluble micropin in skin surface, after soluble micropin is pierced into skin, patch substrate is adhered to skin table
Face, patch depart from naturally with acupuncture portion；
Step 3: treating that dissolving and release function cosmetics or active constituents of medicine occur in skin for soluble micropin, tear
Patch.
9. soluble micropin introducing apparatus application method, it is characterised in that：The method is using described in any one of Claims 1 to 4
Soluble micropin introducing apparatus, this method includes：
Step 1: according to skin surface, corresponding acupuncture portion is selected, wherein, soluble micropin vertical section, can in arrowhead-shaped
Functional cosmetics or active constituents of medicine are equipped with dissolubility micropin, the viscosity between soluble micropin and patch is less than acupuncture
Adsorption capacity between portion and patch；
Step 2: acting on soluble micropin in skin surface, after soluble micropin is pierced into skin, soluble micropin is embedded in skin
It is interior and separated with patch；
Step 3: dissolving and release function cosmetics or active constituents of medicine occur in skin for soluble micropin.
10. solubility micropin introducing apparatus application method according to claim 9, it is characterised in that：Further include step 4：
Skin surface is smeared functional cosmetics or active constituents of medicine and is conducted with carrying out various medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711361424.0A CN108014413A (en) | 2017-12-18 | 2017-12-18 | Soluble micropin introducing apparatus and its application method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711361424.0A CN108014413A (en) | 2017-12-18 | 2017-12-18 | Soluble micropin introducing apparatus and its application method |
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| Publication Number | Publication Date |
|---|---|
| CN108014413A true CN108014413A (en) | 2018-05-11 |
Family
ID=62074062
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|---|---|---|---|
| CN201711361424.0A Pending CN108014413A (en) | 2017-12-18 | 2017-12-18 | Soluble micropin introducing apparatus and its application method |
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| CN108379095A (en) * | 2018-05-24 | 2018-08-10 | 优微（珠海）生物科技有限公司 | A kind of solubility microneedle patch and preparation method thereof |
| CN110279934A (en) * | 2019-06-19 | 2019-09-27 | 青岛华澳现代医疗美容有限公司 | Micropin is used in autogenous repairing activation |
| CN111643805A (en) * | 2020-07-02 | 2020-09-11 | 陆小龙 | Local analgesia microneedle device for neuropathic pain |
| CN112604148A (en) * | 2020-12-28 | 2021-04-06 | 深圳由莱智能电子有限公司 | Beauty treatment handle |
| CN112691012A (en) * | 2020-12-30 | 2021-04-23 | 北京轻奢国济医疗美容诊所有限公司 | Three-dimensional integrative self-repairing device of micropin |
| CN113244162A (en) * | 2021-05-24 | 2021-08-13 | 杭州荔枝红生物科技有限公司 | Soluble microneedle, preparation method thereof and application of soluble microneedle in preparation of product for regulating skin microecology |
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| CN112604148A (en) * | 2020-12-28 | 2021-04-06 | 深圳由莱智能电子有限公司 | Beauty treatment handle |
| CN112691012A (en) * | 2020-12-30 | 2021-04-23 | 北京轻奢国济医疗美容诊所有限公司 | Three-dimensional integrative self-repairing device of micropin |
| CN113244162A (en) * | 2021-05-24 | 2021-08-13 | 杭州荔枝红生物科技有限公司 | Soluble microneedle, preparation method thereof and application of soluble microneedle in preparation of product for regulating skin microecology |
| CN113244162B (en) * | 2021-05-24 | 2022-08-02 | 杭州荔枝红生物科技有限公司 | Soluble microneedle, preparation method thereof and application of soluble microneedle in preparation of product for regulating skin microecology |
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