CN103203072A - Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch - Google Patents
Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch Download PDFInfo
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- CN103203072A CN103203072A CN2013100971646A CN201310097164A CN103203072A CN 103203072 A CN103203072 A CN 103203072A CN 2013100971646 A CN2013100971646 A CN 2013100971646A CN 201310097164 A CN201310097164 A CN 201310097164A CN 103203072 A CN103203072 A CN 103203072A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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Abstract
The invention discloses a metal micro-needle array flexible patch, a transdermal applicator and a transdermal application patch. The metal micro-needle array flexible patch comprises a flexible substrate and at least two metal micro-needle modules which are arranged at certain intervals and fixed on the bottom surface of the flexible substrate or partially inset in the flexible substrate. Each metal micro-needle module is a metal sheet with projecting micro-needles on the edge, or a metal sheet fixed on a needle holder and provided with projecting micro-needles on the edge, or composed of metal micro-needles separately erected and fixed on a needle holder. The micro-needles are perpendicular to the surface of the flexible substrate and are hollow or solid metal micro-needles with a tip pointing out. The micro-needle array is organically combined with the flexible substrate, so that medicine is allowed to directly pass corneum to quickly enter the human body. The metal micro-needle array flexible patch is comfortable to use and evident in efficacy.
Description
Technical field
The present invention relates to medical beauty treatment instrument and medical technical field, particularly relate to a kind of metal micro-needle array flexible paster, percutaneous dosing device and percutaneous dosing paster.
Background technology
Transdermal delivery system claims Transcutaneous Therapeutic System again, refers to that medicine enters a class preparation that body circulation produce drug effect by skin through the blood capillary absorption with certain speed.Compare with traditional administering mode, percutaneous dosing has many advantages: can produce lasting, constant and controlled blood drug level, make because the body intracellular metabolic rapidly and very short pharmaceutically active of half-life obviously improves, avoided the first pass effect of liver and the interference of gastrointestinal factors, toxic and side effects has been dropped to minimum; Have painless, noinvasive or invasive, but patient's self-medication, and also interruption of the administration at any time is easy to use.Though percutaneous dosing is very tempting, when the medicine that advance into percutaneous dosing market, the world have only 20 surplus kind, this mainly is because the barrier effect of keratodermatitis causes the transdermal penetration speed of most medicines too low, can not satisfy the needs for the treatment of.Medicine that now can percutaneous dosing is subjected to many restrictions, for example molecular weight less than 500D, fat-solubility, fusing point less than 150 ℃, therapeutic dose less than 20 milligrams/day etc., macromolecule and polar medicine are difficult to realize passive percutaneous dosing.
In order to increase the permeability of skin, people have adopted several different methods such as chemical penetrating agent, iontherapy and electroporation method.All there is in various degree limitation in these methods to the medicine that transmits, and some may also can cause bigger toxic and side effects.1998, U.S. Prausnitz professor seminar at first is used for the percutaneous dosing field with miniature solid silicon pin array, find that it can improve 4 orders of magnitude with the percutaneous permeation of biopolymer model drug calcein, has from then on started the tide of microneedle transdermal delivery research in the world.The pin mode of executing by pressing microneedle array can moment obviously improves the permeability of medicine in the duct that keratodermatitis and epidermal area produce a large amount of micron dimension sizes, should be applicable to any medicine that comprises biopharmaceutical macromolecular drug in theory and be not subjected to the restriction of molecular weight size, medicine polarity, fusing point etc.Because sharp short and small, the medicine-feeding part of micropin does not touch nervous tissue and blood vessel at body surface, therefore can not produce pain and bleeding; Adopt the micropin administration not need the professional to operate, flexible and convenient to use, interruption of the administration at any time is so accepted by the patient easilier.
With percutaneous dosing in like manner because cuticular barrier effect, adopt general traditional method to use cosmetics and skincare product, most active nutrients wherein are difficult to enter active epidermal area and skin corium, so cosmetic result is not remarkable.If have the microneedle array of cosmetics and skincare product to thrust skin surface applied, or microneedle array thrusts to remove behind the skin and repastes deposited cosmetics and skincare product, all can obviously improve active nutrient and pass through the penetrating power that horny layer enters epidermal area and skin corium cell, thereby significantly improve the looks improving and the skin nourishing effect.
The material of making micropin has polymer, monocrystal silicon and metal etc.The outstanding problem that existing polymer micro needle exists is that the strength of materials is not enough, is difficult for piercing through the fine and close horny layer of skin; Though can make the monocrystal silicon pin in batches, its easy brittle failure, cost are very high, and silicon does not also belong to conventional medical material; For a long time, people adopt metal to make acupuncture needle or injection needle always, and the safety of its use is unquestionable.At present, reported some metal micro-needle array structures, it mainly is to produce microneedle array at same nugget genus substrate, and micropin is vertical with substrate or coplanar.Owing to adopt the microneedle array structure quality of metal substrate harder, and people's skin is softer, the two is difficult for closely contacting at the applying position of health, will cause considerable micropin to be suspended in aerial and can't thrust skin, the actual dosage of percutaneous is difficult to accurate control, thereby generation has a strong impact on to curative effect.In addition, how cover medicine as much as possible and thrusting in the skin process at very thin short and small micropin and can not come off, this also is the key issue that must solve in the practicality undoubtedly.
Summary of the invention
(1) technical problem that will solve
The objective of the invention is to realize that the metal micro-needle array plaster can change with the skin shape at applying position, guarantee that all micropins can both thrust skin, improve the comfortableness of using;
Another object of the present invention is to improve the metal micro-needle array plaster is executed pin by turns in a plurality of administered area convenience.
(2) technical scheme
In order to solve the problems of the technologies described above, the invention provides a kind of metal micro-needle array flexible paster, described paster comprises flexible substrate, and at least two are arranged and are fixed on described flexible substrate surface at a certain distance or are partly embedded in the interior metal micro-needle module of described flexible substrate; Described metal micro-needle module is that the edge has the foil that protrudes micropin, or is fixed on the needle stand and the edge has the foil that protrudes micropin, or is fixed on the discrete metal micro-needle on the needle stand; Described micropin and flexible substrate Surface Vertical, and the needle point of described micropin outwards protrudes; Described micropin is solid or hollow metal micro-needle.
Wherein, described micropin is 10 microns～1500 microns for the length of the projection that thrusts, and the external diameter of micropin or width are 10 microns～1000 microns, and the thickness of described foil is 5 microns～800 microns.
Wherein, the needle point end of described micropin has and prevents the spearhead shape structure that it withdraws from automatically after thrusting, and described spearhead shape structure comprises that the card that protrudes the micropin sidewall is protruding.
Wherein, described needle stand is cuboid or polyhedral, at least fixing described foil or fixing described discrete metal micro-needle in an one side.
Wherein, have perforation and/or groove on the described micropin, when having groove on the described micropin, described groove is along the length direction setting of described micropin.
Wherein, described flexible substrate is polygon or round or disciform lamellar or network structure, or formed by at least two list structures, the material that adopts includes but not limited to by weaving cotton cloth of textile fiber or weaving cotton cloth or thin slice, filament or the fillet of non-woven fabrics, rubber, plastics, synthetic leather, paper, metal of elastic fiber, described flexible substrate can be made of or several layering combines a kind of in the above-mentioned material, connects by adhesive or fixed structure between each layer.
The present invention also provides a kind of percutaneous dosing device that adopts above-mentioned arbitrary described metal micro-needle array flexible paster, described percutaneous dosing device comprises metal micro-needle array flexible paster and pedestal, described pedestal one end is the paster stationary plane, the other end is operating grip, described paster stationary plane is plane or arc-shaped curved surface, described metal micro-needle array flexible paster is permanent or removably be fixed on the described paster stationary plane, and perhaps described metal micro-needle array flexible paster is partially submerged in the described paster stationary plane.
The present invention provides a kind of percutaneous dosing paster that adopts above-mentioned arbitrary described metal micro-needle array flexible paster again, described percutaneous dosing paster comprises metal micro-needle array flexible paster and covering percutaneous patch thereon, and described percutaneous patch contains one or more ingredient with treatment, health care or effects of beautification and nourishing face or cosmetics and skincare products.
Wherein, described percutaneous patch is covered on the micropin that protrudes in the metal micro-needle array flexible paster.
Wherein, on the flexible substrate of described metal micro-needle array flexible paster, the surface coverage of border area has medical adhesive material around it at least, is used for described percutaneous dosing paster is sticked on medicine-feeding part.
(3) beneficial effect
Technique scheme adopts conventional at present medical material and utilizes ripe process technology to make metal micro-needle array flexible paster, because the flexible substrate that adopts is easy and skin surface is conformal, guarantee that all micropins on it can both thrust skin smoothly, thereby obviously improved concordance and the controllability of dosage, and used and feel more comfortable, convenient; Metal micro-needle is firm in structure, needle point sharp short and small, be convenient to the puncture; Micropin high conformity in the array does not have pain, loses blood during use, use the rapid spontaneous recovery of skin meeting of back Wicresoft, and is safe and reliable.
The percutaneous dosing device that employing is core parts with above-mentioned metal micro-needle array flexible paster, just can own operate in a plurality of administered area flexibly and easily with hands and execute pin by turns, the metal micro-needle array is removed after thrusting skin very soon, apply medicament and be beneficial to its diffusion performance drug effect rapidly thrusting area surfaces then, easy to use, pesticide supplying effect is good.
Employing is the percutaneous dosing paster of core parts with above-mentioned metal micro-needle array flexible paster, not only obviously improved drug storage amount placed on it in advance, and can reduce greatly and execute pin process Chinese medicine and come off in external probability, thereby can make transdermal patch select the medicine scope, effectively treatment time and cost performance are significantly improved.Adopt the paster of the present invention's preparation not only can significantly improve the transdermal penetration rate that has medicine now, make medicine or cosmetics and skincare product enter epidermal area and skin corium by horny layer rapidly, obviously improve drug effect or looks improving and the skin nourishing effect, can also expand the kind that is suitable for medicine, develop the more percutaneous novel form of multiple medicines thing and cosmetics.
Description of drawings
The foil that Fig. 1 has a micropin for edge in the embodiment of the invention 1 is fixed on the structural representation of a kind of metal micro-needle array flexible paster on needle stand and the flexible substrate;
Fig. 2 is fixed on the structural representation of a kind of metal micro-needle array flexible paster on needle stand and the flexible substrate for discrete metal micro-needle in the embodiment of the invention 1;
Fig. 3 is for all having groove on micropin in the embodiment of the invention 1 and the foil and being fixed on the structural representation of a kind of metal micro-needle array flexible paster on flexible substrate surface;
The foil that Fig. 4 has a micropin for edge in the embodiment of the invention 1 is fixed on the structural representation of a kind of metal micro-needle array flexible paster of strip flexible substrate;
The foil that Fig. 5 has a micropin for edge in the embodiment of the invention 1 is fixed on the structure cutaway view of a kind of metal micro-needle array flexible paster on the flexible substrate;
The foil that Fig. 6 has a micropin for edge in the embodiment of the invention 1 is fixed on the structure cutaway view of the another kind of metal micro-needle array flexible paster on the flexible substrate;
The foil that Fig. 7 has a micropin for edge in the embodiment of the invention 1 is fixed on the structure cutaway view of the another kind of metal micro-needle array flexible paster on the flexible substrate;
The foil that Fig. 8 has a micropin for edge in the embodiment of the invention 1 is fixed on the structure cutaway view of the another kind of metal micro-needle array flexible paster on the flexible substrate;
Fig. 9 is fixed on the structure cutaway view of a kind of metal micro-needle array flexible paster on needle stand and the flexible substrate for discrete metal micro-needle in the embodiment of the invention 1;
Figure 10 is a kind of percutaneous dosing device architecture cutaway view of applied metal microneedle array flexible paster in the embodiment of the invention 2;
Figure 11 is the another kind of percutaneous dosing device architecture cutaway view of applied metal microneedle array flexible paster in the embodiment of the invention 2;
Figure 12 is another percutaneous dosing device architecture cutaway view of applied metal microneedle array flexible paster in the embodiment of the invention 2.
Wherein, 1: flexible substrate; 2: micropin; 3: foil; 4: needle stand; 5: needle point; 6: fixedly connected layer; 7: the hole; 8: groove; 9: pedestal; 10: the hands handle; 11: projection.
The specific embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is described in further detail.Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Fig. 1-Fig. 9 shows metal micro-needle array flexible paster provided by the present invention, described paster comprises flexible substrate 1, and at least two arranged and be fixed on described flexible substrate 1 surface at a certain distance or be partly embedded in metal micro-needle module in the described flexible substrate 1, described metal micro-needle module is that edge has the foil 3 that protrudes micropin 2, or be fixed on the needle stand 4 and edge has the foil 3 that protrudes micropin 2, or be fixed on discrete metal micro-needle 2 on the needle stand 4, described micropin 2 and flexible substrate 1 Surface Vertical, and the needle point of described micropin 2 outwards protrudes.By this metal micro-needle array flexible paster, can realize paster surperficial conformal with the dispenser position, guarantee that micropin 2 can both thrust dispenser skin simultaneously, improve the effect of dispenser.
The surface that described foil 3 can be parallel to flexible substrate 1 arranges, also can arrange perpendicular to the surface of flexible substrate 1, set-up mode according to foil 3, can select micropin 2 with respect to foil 3 Surface Vertical settings or with foil 3 coplanar settings, only need finally to realize micropin 2 perpendicular to flexible substrate 1 surface and outwards protrude getting final product.
In the present embodiment, micropin 2 is solid or hollow metal micro-needle, and both all can realize good pesticide supplying effect.Described micropin 2 is 10 microns～1500 microns for the length of the projection that thrusts, the external diameter of micropin 2 or width are 10 microns～1000 microns, the thickness of described foil 3 is 5 microns～800 microns, can play the needs that pesticide supplying effect can not injure dermis of skin again to satisfy in the conventional percutaneous dispenser.
At least have a foil 3 or a discrete metal micro-needle 2 on the present embodiment metal micro-needle module, described foil 3 has the micropin 2 of a protrusion at least in the one side edge.The microneedle array that has micropin 2 compositions of at least two protrusions arranging according to the setting spacing on the described metal micro-needle module.
Fig. 1 is the structural representation of a kind of metal micro-needle array flexible paster in the embodiment of the invention, on flexible substrate 1, arrange and fixing nine metal micro-needle modules at a certain distance, each metal micro-needle module comprises the needle stand 4 of a cuboid, at its relative place, two sides a foil 3 is arranged fixedly respectively, place, the limit of each foil 3 all has according to the microneedle array of setting that spacing is arranged and outwards protruding and form perpendicular to two micropins 2 of needle stand 4, micropin 2 is coplanar with the principal plane of foil 3, have in needle point 5 ends of micropin 2 and to prevent that it from withdrawing from the spearhead shape structure of effect automatically after thrusting, described spearhead shape structure comprises that the card that protrudes the micropin sidewall is protruding.
Be another kind of metal micro-needle array flexible paster among Fig. 2, be to adopt discrete metal micro-needle 2 to replace the place, limit with the main distinction of Fig. 1 and have the foil 3 that protrudes micropin 2 that the needle point of micropin 2 does not have spearhead shape structure in addition.The size of adjacent metal micropin module and structure can be not quite similar in the paster.The shape of needle stand 4 can be varied with the making material, metal is fixed thereon to get final product easily.As preferably, needle stand is cuboid or polyhedral, can adopt polymer to make, and as adopting making such as epoxy resin, also can adopt manufacturings such as metal, pottery.Described metal can be multiple medical metal materials such as rustless steel, titanium alloy.Micropin 2 is on the needle stand 4 or foil 3 fixing on needle stand 4, can adopt medical adhesive such as epoxy resin, silicone rubber or special construction to fix.
Metal micro-needle array flexible paster and Fig. 1 among Fig. 3,2 the main distinction are to arrange at a certain distance on the flexible substrate 1 and fixing three metal micro-needle modules on the one hand, each metal micro-needle module has 4 foils 3 that protrude micropin 2 by the place, limit and forms, micropin 2 is vertical with the principal plane of foil 3, and this foil 3 can adopt fixedly connected layer that the agent of epoxy resin gluing forms 6 directly to be fixed on the flexible substrate 1 according to a determining deviation; On the other hand, all has groove 8 on micropin 2 and the foil 3, groove 8 is along the length direction setting of described micropin 2, equal and the sunk structures that form bent to a lateral bending in all or part of zone of micropin 2 or micropin 2 and the both side surface of foil 3 specifically, or the sunk structure that forms with the side surface portion zone fluting of foil 3 of micropin 2 or micropin 2, the groove structure that has on the micropin 2 is very beneficial for carrying more medicine and can effectively avoids thrusting skin process Chinese medicine and come off in external.
Metal micro-needle array flexible paster is on the one hand that with the main distinction of Fig. 3 the shape of needle point 5 is different among Fig. 4, be the shape difference of flexible substrate 1 on the other hand, one is tetragonal laminated structure, is made up of four list structures for one, and flexibility and the permeability of list structure substrate are better.The shape of flexible substrate can be varied with the making material, as preferably, it is polygon or circular or oval-shaped lamellar or network structure, or formed by at least two list structures, the material that adopts includes but not limited to by weaving cotton cloth of textile fiber or weaving cotton cloth or thin slice, filament or the fillet of non-woven fabrics, rubber, plastics, synthetic leather, paper, metal of elastic fiber, can be constituted or several layering combines by wherein a kind of, connect by adhesive or fixed structure between each layer.
Fig. 5 has the structure cutaway view that the foil 3 that protrudes micropin 2 is fixed on a kind of metal micro-needle array flexible paster on the flexible substrate 1 for place, limit in the embodiment of the invention.Wherein, micropin 2 is vertical with the principal plane of foil 3, adopts adhesive foil 3 to be fixed on the upper surface of flexible substrate 1.
Metal micro-needle array flexible paster and the difference of Fig. 5 are that two relative places, limit of foil 3 all have the micropin 2 of protrusion among Fig. 6.
The difference of metal micro-needle array flexible paster and Fig. 5 is that micropin 2 penetrates the upper surface of flexible substrate 1 among Fig. 7, adopts adhesive foil 3 to be fixed on the lower surface of flexible substrate 1.
The difference of metal micro-needle array flexible paster and Fig. 5～7 is that flexible substrate is made up of materials at two layers among Fig. 8, and foil 3 embeds also and is fixed between the two, guarantees whole paster structure firm stable more.What select for use as the upper strata of flexible substrate is the silicone rubber elastomeric material, and it is attached on the skin during use, and comfort can be stronger.
The main distinction of metal micro-needle array flexible paster and Fig. 5～8 is that discrete metal micro-needle 2 is fixed on the flexible substrate 1 by needle stand 4 among Fig. 9, and have on the metal micro-needle 2 be used to storing the more hole 7 of multiple medicines thing, can carry more by hole 7 that the multiple medicines thing carries out percutaneous dosing, and can not cause medicine to come off in external.
Metal micro-needle array flexible paster of the present invention can adopt existing ripe processing technique to make in batches.For example adopt conventional methods such as cut, electric spark cutting, punching press shearing, chemistry or electrochemical corrosion just can process various microneedle configuration in the edge of foil.If make discrete metal micro-needle with solid metal silk or hollow metal capillary tube, adopt conventional grinding and polishing can process multiple common needle point structure, the multiple medicines thing enters skin to utilize through hole on the hollow needle to can be used for carrying more.Can adopt existing ripe package technique to prepare metal micro-needle array flexible paster at last.
Figure 10 and Fig. 9 are the percutaneous dosing device architecture cutaway view of the above-mentioned metal micro-needle array flexible of application provided by the invention paster, described percutaneous dosing device comprises metal micro-needle array flexible paster and pedestal 9, described pedestal 9 one ends are the paster stationary plane, the other end is operation handle 10, described paster stationary plane is plane or arc-shaped curved surface, described metal micro-needle array flexible paster is permanent or removably be fixed on the described paster stationary plane, and perhaps described metal micro-needle array flexible paster is partially submerged in the described paster stationary plane.
In Figure 10, metal micro-needle array flexible paster is fixed on the plane paster stationary plane of pedestal 9 one ends, and the needle point structure of micropin 2 and aforementioned each figure are all inequality, are specially the needle point structure that has the inclined-plane.
Among Figure 11 the main distinction of percutaneous dosing device and Figure 10 be flexible patch around pedestal 9 be provided with projection 11 and thrust the degree of depth with the maximum that limits micropin 2, also be equivalent to metal micro-needle array flexible paster and be partially submerged in the described paster stationary plane, remain with the projection that can play barrier effect around the flexible patch.
The main distinction of percutaneous dosing device and Figure 10, Figure 11 is that metal micro-needle array flexible paster is fixed on the arc-shaped surface shape paster stationary plane of pedestal 9 one ends among Figure 12, their handle 10 is also inequality in addition, handle 10 can be set to column or ellipsoid shape or column and combine with the ellipsoid shape, only needs to satisfy hand-held comfortable getting final product.
The embodiment of the invention provides a kind of percutaneous dosing paster based on above-mentioned metal micro-needle array flexible paster, it is made up of metal micro-needle array flexible paster and covering percutaneous patch thereon, and percutaneous patch wherein contains one or more ingredient with treatment, health care or effects of beautification and nourishing face or cosmetics and skincare products.As preferably, described percutaneous patch only is covered on the micropin that protrudes in the metal micro-needle array flexible paster or on the needle point, medicament that like this not only can saves valuable, and also control enters the dose of skin easily.Groove on the micropin and hole not only can be used for storing more medicine, and can effectively avoid this place's medicine to come off in external problem in thrusting the skin process.Can adopt multiple physical property commonly used such as dipping, coating, stifling, deposit or chemical method to cover percutaneous administration patch or cosmetic patch at microneedle array even flexible substrate.
In use, at first the microneedle array on the percutaneous dosing paster is all thrust skin, can this paster be fixed with common medical adhesive tape then.As preferably, can described percutaneous dosing paster be sticked on medicine-feeding part at the medical adhesive material of surface coverage in the zone, edge of paster flexible substrate, it is more convenient to use.
The present invention adopts the medical material manufacturing of present routine based on percutaneous dosing paster, the Beauty sticking piece of metal micro-needle array flexible paster, combination by microneedle array and flexible substrate can make medicine or cosmetics and skincare product enter epidermal area and skin corium by horny layer rapidly, thereby obviously improve drug effect or looks improving and the skin nourishing effect, and utilize ripe processing technique to realize the batch manufacturing of its low cost, high finished product rate, high duplication; Because the flexible substrate that adopts is easy and skin is conformal, uses and feel more comfortable, convenient; Microneedle configuration is firm, needle point is sharp, be convenient to puncture; Micropin high conformity in the array does not have pain, loses blood during use, use the rapid spontaneous recovery of skin meeting of back Wicresoft, and is safe and reliable; The more multiple medicines thing that carries in groove or the hole on the micropin has guaranteed that paster is can action time longer; The use amount of chemical penetrating agent can be avoided or reduce significantly to this paster fully, not only can significantly improve the transdermal penetration rate of existing medicine, can also expand the kind that is suitable for medicine, and developing more, the percutaneous of multiple medicines thing and cosmetics transports product.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvement and replacement, these improvement and replacement also should be considered as protection scope of the present invention.
Claims (10)
1. a metal micro-needle array flexible paster is characterized in that described paster comprises flexible substrate, and at least two are arranged and are fixed on described flexible substrate surface at a certain distance or are partly embedded in the interior metal micro-needle module of described flexible substrate; Described metal micro-needle module is that the edge has the foil that protrudes micropin, or is fixed on the needle stand and the edge has the foil that protrudes micropin, or is fixed on the discrete metal micro-needle on the needle stand; Described micropin and flexible substrate Surface Vertical, and the needle point of described micropin outwards protrudes; Described micropin is solid or hollow metal micro-needle.
2. metal micro-needle array flexible paster as claimed in claim 1, it is characterized in that, described micropin is 10 microns～1500 microns for the length of the projection that thrusts, and the external diameter of micropin or width are 10 microns～1000 microns, and the thickness of described foil is 5 microns～800 microns.
3. metal micro-needle array flexible paster as claimed in claim 1 is characterized in that, the needle point end of described micropin has and prevents the spearhead shape structure that it withdraws from automatically after thrusting, and described spearhead shape structure comprises that the card that protrudes the micropin sidewall is protruding.
4. metal micro-needle array flexible paster as claimed in claim 1 is characterized in that, described needle stand is cuboid or polyhedral, at least fixing described foil or fixing described discrete metal micro-needle in an one side.
5. metal micro-needle array flexible paster as claimed in claim 1 is characterized in that, has perforation and/or groove on the described micropin, and when having groove on the described micropin, described groove is along the length direction setting of described micropin.
6. metal micro-needle array flexible paster as claimed in claim 1, it is characterized in that, described flexible substrate is polygon or round or disciform lamellar or network structure, or formed by at least two list structures, the material that adopts includes but not limited to by weaving cotton cloth of textile fiber or weaving cotton cloth or thin slice, filament or the fillet of non-woven fabrics, rubber, plastics, synthetic leather, paper, metal of elastic fiber, described flexible substrate can be made of or several layering combines a kind of in the above-mentioned material, connects by adhesive or fixed structure between each layer.
An employing arbitrary as claim 1-6 as described in the percutaneous dosing device of metal micro-needle array flexible paster, it is characterized in that, described percutaneous dosing device comprises metal micro-needle array flexible paster and pedestal, described pedestal one end is the paster stationary plane, the other end is operating grip, described paster stationary plane is plane or arc-shaped curved surface, described metal micro-needle array flexible paster is permanent or removably be fixed on the described paster stationary plane, and perhaps described metal micro-needle array flexible paster is partially submerged in the described paster stationary plane.
An employing arbitrary as claim 1-6 as described in the percutaneous dosing paster of metal micro-needle array flexible paster, it is characterized in that, described percutaneous dosing paster comprises metal micro-needle array flexible paster and covering percutaneous patch thereon, and described percutaneous patch contains one or more ingredient with treatment, health care or effects of beautification and nourishing face or cosmetics and skincare products.
9. percutaneous dosing paster as claimed in claim 8 is characterized in that, described percutaneous patch is covered on the micropin that protrudes in the metal micro-needle array flexible paster.
10. percutaneous dosing paster as claimed in claim 9, it is characterized in that, on the flexible substrate of described metal micro-needle array flexible paster, the surface coverage of border area has medical adhesive material around it at least, is used for described percutaneous dosing paster is sticked on medicine-feeding part.
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| CN201310097164.6A CN103203072B (en) | 2013-03-25 | 2013-03-25 | Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014187338A1 (en) * | 2013-05-22 | 2014-11-27 | 清华大学 | Metal microneedle array, transdermal delivery patch, and microneedle transdermal delivery stamp |
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| WO2014187338A1 (en) * | 2013-05-22 | 2014-11-27 | 清华大学 | Metal microneedle array, transdermal delivery patch, and microneedle transdermal delivery stamp |
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| CN113908424A (en) * | 2014-04-24 | 2022-01-11 | 佐治亚科技研究公司 | Microneedle and method for producing same |
| CN106232159A (en) * | 2014-04-24 | 2016-12-14 | 佐治亚科技研究公司 | Micropin and its manufacture method |
| US10828478B2 (en) | 2014-04-24 | 2020-11-10 | Georgia Tech Research Corporation | Microneedles and methods of manufacture thereof |
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| GB2533839B (en) * | 2014-11-25 | 2020-09-16 | Xobaderm Ltd | Micropenetrator device for penetrating a biological barrier |
| US10532200B2 (en) | 2014-11-25 | 2020-01-14 | Xobaderm Limited | Micropenetrator device for penetrating a biological barrier |
| AU2015352176B2 (en) * | 2014-11-25 | 2020-08-06 | Xobaderm Limited | Micropenetrator device for penetrating a biological barrier |
| WO2016083803A3 (en) * | 2014-11-25 | 2016-07-21 | Xobaderm Limited | Micropenetrator device for penetrating a biological barrier |
| GB2533839A (en) * | 2014-11-25 | 2016-07-06 | Xobaderm Ltd | Micropenetrator device for penetrating a biological barrier |
| CN109069812A (en) * | 2016-04-07 | 2018-12-21 | 实验室和人们 | Utilize the micropin of biological absorbable metal |
| CN109069812B (en) * | 2016-04-07 | 2021-05-07 | 实验室和人们 | Microneedles using bioabsorbable metals |
| JP2019025047A (en) * | 2017-07-31 | 2019-02-21 | 凸版印刷株式会社 | Percutaneous administration device |
| CN108014413A (en) * | 2017-12-18 | 2018-05-11 | 优微（珠海）生物科技有限公司 | Soluble micropin introducing apparatus and its application method |
| CN109303976A (en) * | 2018-11-07 | 2019-02-05 | 何坛明 | A kind of microneedle configuration that medicaments uniformity distribution imports |
| CN110076528A (en) * | 2019-05-13 | 2019-08-02 | 大连理工大学 | A kind of planar metal microneedle array and preparation method thereof |
| CN112617822A (en) * | 2019-11-19 | 2021-04-09 | 奇异平台股份有限公司 | Percutaneous microneedle monitoring system |
| CN114699510A (en) * | 2021-12-29 | 2022-07-05 | 浙江湃肽生物有限公司 | Simelide microneedle array and preparation method thereof |
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