CN203436688U - Metal microneedle array, transdermal delivery patch, microneedle delivery stamp, microneedle cosmetology stamp, microneedle roller and microneedle electrode array - Google Patents
Metal microneedle array, transdermal delivery patch, microneedle delivery stamp, microneedle cosmetology stamp, microneedle roller and microneedle electrode array Download PDFInfo
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- CN203436688U CN203436688U CN201320284037.2U CN201320284037U CN203436688U CN 203436688 U CN203436688 U CN 203436688U CN 201320284037 U CN201320284037 U CN 201320284037U CN 203436688 U CN203436688 U CN 203436688U
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- micropin
- microneedle
- metal micro
- foil
- needle array
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Abstract
The utility model provides a metal microneedle array, a transdermal delivery patch, a microneedle delivery stamp, a microneedle cosmetology stamp, a microneedle roller and a microneedle electrode array. The metal microneedle array comprises a substrate, a metal sheet fixed on the surface of the substrate, and/or one metal sheet with one side edge embedded into the substrate, and/or at least two metal sheets which are arranged at certain intervals and fixed on the surface of the substrate, and/or at least two metal sheets which are arranged at certain intervals and each have one side edge embedded into the substrate. A microneedle array protruding outward is arranged on the edge of at least one side of each metal sheet and at least comprises two microneedles arranged at certain intervals, the microneedles protrude out of the surface of the substrate, the microneedles are perpendicular to the surface of the substrate or the microneedles are tilted according to the predetermined angle, the microneedles are perpendicular to a principal plane in which a center area of the corresponding metal sheet exists or the microneedles are coplanar with the center area of the corresponding metal sheet, and one end of each microneedle is a needle point.
Description
Technical field
This utility model relates to medical beauty treatment instrument and medical technical field, particularly relates to a kind of metal micro-needle array and the percutaneous dosing paster based on this kind of array, percutaneous dosing seal and microneedle electrodes array.
Background technology
In recent years, microneedle transdermal delivery is subject to common concern, it can produce the duct of a large amount of micron dimension sizes by pressing the pin mode of executing of microneedle array moment at keratodermatitis and epidermal area, therefore can obviously improve the permeability of medicine, the restriction that should be applicable in theory comprise any medicine of biopharmaceutical macromolecular drug and not be subject to molecular size range, polar drugs, fusing point etc., thus for adopting percutaneous dosing, these medicines established solid foundation.Thrusting before skin, if in the surface coverage of microneedle array especially needle point medicine, can be called microneedle transdermal patch; In addition, remove after also microneedle array directly can being thrust to skin, and then coating medicine spreads administration in executing pin place voluntarily by it.Because sharp short and small, the medicine-feeding part of micropin does not touch nervous tissue and blood vessel at body surface, the aperture that therefore can not produce pain and bleeding ，Qie Wicresoft just can automatically heal within very short time; Adopt micropin administration not need professional to operate, flexible and convenient to use, interruption of the administration at any time, so more easily accepted by patient.
With percutaneous dosing in like manner, adopting in recent years microneedle array to improve looks comes into vogue, use it to form a lot of small holes in inherent skin surface of a few minutes, apply subsequently cosmetics and skincare product, can obviously improve active nutrient and pass through the penetrating power that horny layer enters epidermal area, thereby significantly improve looks improving and the skin nourishing effect.
In addition, the microneedle array of take is measured bioelectric potential as electrode by piercing through the horny layer of skin, can effectively avoid the interference of keratodermatitis high-impedance behavior, with common potential electrode comparison, do not need skin to prepare and electrolytic gel, be more conducive to long-term measurement and use.Therefore, use microneedle array electrode to measure more convenient reliable, there is less impedance, and pre-in respect of less electrochemistry noise, can complete the high-quality record to low bioelectric potential.
The material of manufacturing micropin has polymer, monocrystal silicon and metal etc.The outstanding problem that existing polymer micro needle exists is that the strength of materials is inadequate, is difficult for piercing through the fine and close horny layer of skin; Although can manufacture in batches monocrystal silicon pin, its easy brittle failure, cost are very high, and silicon does not also belong to conventional medical material; For a long time, people adopt metal to manufacture acupuncture needle or injection needle always, and the safety of its use is unquestionable.At present, some metal micro-needle array structures have been reported.On the one hand, for example patent CN1562402A, US20100130940-A1 and CN1415385A, it is mainly to produce microneedle array on same metal substrate, but manufacturing process is complicated, cost is high, the motility of structural design and application is low; On the other hand, for example patent CN102727992A, CN102166387A, CN101829396A, it is mainly on the substrate of other material, to adopt single metal micropin to arrange and assemble the microneedle array forming according to a determining deviation, has equally the problem that manufacturing process is comparatively complicated, cost is higher, concordance is poor.
Utility model content
(1) technical problem that will solve
First technical problem to be solved in the utility model is between the micropin of not only guaranteeing in metal micro-needle array, to have good concordance, and the simplified manufacturing technique of can trying one's best, significantly reduces costs and improve the motility of structural design and application.
Second technical problem to be solved in the utility model is the drug storage amount that increases each micropin in metal micro-needle array percutaneous dosing paster, the little and medicine difficult drop-off that carries of the sharp keen power of thrusting of needle point, and drug effect performance is rapidly, action time is more lasting.
The 3rd technical problem to be solved in the utility model is to be convenient in a plurality of administered area rotations, execute pin with metal micro-needle array of hand operated, metal micro-needle array is removed after thrusting skin, applies medicament and is beneficial to its diffusion performance drug effect rapidly thrusting region surface subsequently.
The 4th technical problem to be solved in the utility model is to utilize metal micro-needle array to make a kind of microneedle electrodes array, and it not only can effectively improve the signal to noise ratio that bioelectric potential detects, and can also to skin, apply various electrical signal by it.
(2) technical scheme
For solving first technical problem, this utility model provides a kind of metal micro-needle array, comprising: substrate; With a foil that is fixed on described substrate surface; And/or a side is along being embedded in the foil in described substrate; And/or at least two foils of arranging at a certain distance and being fixed on described substrate surface; And/or at least two arrange at a certain distance and a side along being embedded in the foil in described substrate; Wherein, described foil at least has outwardly microneedle array at the edge of one side, described microneedle array at least comprises two according to the micropin of certain arranged with interval, described micropin protrudes described substrate surface perpendicular or tilt for set angle, and described micropin is vertical or coplanar with the principal plane at the place, central area of described foil, one end of described micropin is needle point.
Preferably, described substrate is at least comprised of a plane or curved surface thin slice or thin plate, or at least a hollow or solid multiaspect or curved body, consists of.
Preferably, at least one in the following material of described substrate employing made: polymer, timber, metal, pottery, glass.
Preferably, described foil is fixed on described substrate surface by fixed structure and/or adhesive.
Preferably, a side edge of described foil is fixed in described substrate by fixed structure and/or adhesive, the surface that the border area of the opposite side of described foil between micropin protrudes recessed or fair substrate.
Preferably, have locating slot array on described substrate, a side of described foil is along being embedded in locating slot.
Preferably, on the micropin of described foil and/or edge, there is groove or groove and projection, described groove refers to that a side surface subregion smooth and opposite side surface of micropin or micropin and foil is recessed, or the equal and recessed row structures that form crooked to certain direction in all or part of region of the both side surface of micropin or micropin and foil, described groove and projection are the surperficial punching press of foil and micropin one side to be formed recessed, and correspondingly the same position at opposite side forms projection.
Preferably, the needle point of described micropin has after thrusting and prevents the spearhead shape structure that it exits automatically, and described spearhead shape structure comprises the card convex of protruding micropin sidewall.
For solving second technical problem; this utility model provides a kind of microneedle transdermal delivery paster that adopts above-mentioned metal micro-needle array; described microneedle transdermal delivery paster comprises metal micro-needle array, covers percutaneous patch and protecting film or protective bag thereon; described percutaneous patch contains one or more ingredient with treatment, health care or effects of beautification and nourishing face or cosmetics and skincare products, and described protecting film or protective bag have the effect of sealing and protection micropin and the percutaneous patch that covers thereof above.
For solving the 3rd technical problem; this utility model provides a kind of micropin administration seal or micropin beauty treatment seal that adopts above-mentioned metal micro-needle array; described micropin administration seal or micropin beauty treatment seal comprise metal micro-needle array, pedestal and protective cap; described metal micro-needle array is permanent or be removably fixed on one end of pedestal; the other end of described pedestal has is convenient to manual handle arrangement, and described protective cap can be enclosed within on pedestal protects micropin injury-free.
For solving the 3rd technical problem; this utility model also provides a kind of micropin roller that adopts above-mentioned metal micro-needle array; described micropin roller comprises metal micro-needle array, support and the protective cap of cylindrical shape or cydariform substrate; one end of described support also can make metal micro-needle array freely rotate around it as the axle center support substrates of roller; the other end has is convenient to manual handle arrangement, and described protective cap can be enclosed within on support protects micropin injury-free.
For solving the 4th technical problem, this utility model provides a kind of microneedle electrodes array that adopts above-mentioned metal micro-needle array, described microneedle electrodes array comprises the external wire that metal micro-needle array is connected with foil with on it, on the side of described metal micro-needle array and/or the back side, be provided with the interface being connected with external wire, described external wire at least has two, is set to short circuit or open circuit between different metal thin slice.
(3) beneficial effect
This utility model can utilize the very ripe process technologies of industrial quarters such as laser, electric spark, electrochemical corrosion, punching press to produce in batches the foil that edge has micropin, and the structure of micropin and foil and size can be versatile and flexible, adopt computer control can increase substantially machining accuracy and repeatability and concordance; Take other conventional medical materials is substrate, and Batch assemblage goes out the metal micro-needle array of various structure and specifications very easily, not only good looking appearance, firm in structure, concordance is fine and with low cost.
Adopt percutaneous dosing device prepared by this utility model to use safety and flexible, can either carry more medicine, can effectively avoid thrusting again skin process Chinese medicine is come off in external, not only can significantly improve the transdermal penetration rate of existing medicine, make medicine or cosmetics and skincare product by horny layer, enter epidermal area and skin corium rapidly, obviously improve drug effect or looks improving and the skin nourishing effect, can also expand the kind of applicable medicine, develop the more percutaneous novel form of multiple medicines thing and cosmetics.Adopt microneedle electrodes array can effectively avoid the interference of keratodermatitis high-impedance behavior, measure more convenient reliable, signal to noise ratio is high.
Accompanying drawing explanation
Fig. 1 is the structure cutaway view of a kind of metal micro-needle array in this utility model embodiment;
Fig. 2 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Fig. 3 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Fig. 4 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Fig. 5 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Fig. 6 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Fig. 7 is the structural representation of a kind of metal micro-needle array in this utility model embodiment;
Fig. 8 is the structural representation of another kind of metal micro-needle array in this utility model embodiment;
Fig. 9 is the structural representation of another kind of metal micro-needle array in this utility model embodiment;
Figure 10 is the structural representation of another kind of metal micro-needle array in this utility model embodiment;
Figure 11 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Figure 12 is the structural representation of another kind of metal micro-needle array in this utility model embodiment;
Figure 13 is the structural representation of another kind of metal micro-needle array in this utility model embodiment;
Figure 14 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Figure 15 is the structure cutaway view of another kind of metal micro-needle array in this utility model embodiment;
Figure 16 is the structural representation of another kind of metal micro-needle array in this utility model embodiment;
Figure 17 is the structural representation of another kind of metal micro-needle array in this utility model embodiment;
Figure 18 is a kind of administration seal of applied metal microneedle array in this utility model embodiment or the structure cutaway view of beauty treatment seal;
Figure 19 is the another kind of administration seal of applied metal microneedle array in this utility model embodiment or the structure cutaway view of beauty treatment seal;
Figure 20 is the structural representation of a kind of micropin roller of applied metal microneedle array in this utility model embodiment.
Wherein, 1: substrate; 2: foil; 3: the micropin that protrude at place, foil limit; 4: needle point; 5: locating slot; 6: adhesive or fixed structure; 7: groove; 8: pit or through hole; 9: pedestal; 10: hands handle; 11: protective cap; 12: bulge-structure; 13: support; 14: the marginal area on foil between micropin.
The specific embodiment
Below in conjunction with drawings and Examples, the specific embodiment of the present utility model is described in further detail.Following examples are used for illustrating this utility model, but are not used for limiting scope of the present utility model.
Fig. 1-Figure 17 shows metal micro-needle array provided by the utility model, described metal micro-needle array comprises substrate 1, with a foil 2 that is fixed on described substrate 1 surface, and/or a side is along being embedded in the foil 2 in described substrate 1, and/or at least two foils 2 of arranging at a certain distance and being fixed on described substrate 1 surface, and/or at least two arrange at a certain distance and a side along being embedded in the foil 2 in described substrate 1, described foil 2 at least has outwardly micropin 3 arrays at the edge of one side, described micropin 3 arrays at least comprise two according to the micropin of certain arranged with interval 3, described micropin 3 protrudes substrate surfaces perpendicular or be set angle, and micropin 3 is vertical or coplanar with the principal plane at the place, central area of foil 2, one end of described micropin is needle point 4.
The substrate 1 of metal micro-needle array can be comprised of a plane or curved sheets, can adopt polygon, arc, circle or the various shape such as annular, as shown in Fig. 1-Fig. 4 and Fig. 6-Figure 15; Or can be formed by a plurality of planes or curved surface thin slice or thin plate, these thin plates are fixed together by a plurality of foils 2, as shown in Fig. 5 and Figure 16; Or at least by a hollow or solid multiaspect or curved body, formed, it can be rendered as the various shapes such as cylindrical shape or cydariform, as shown in figure 17.
The shape of micropin 3 can be varied, on it, can also have hole.As a kind of preferred, on the micropin 3 of foil 2 and/or edge, there is groove 7 or groove and projection, described groove 7 refers to that a side surface subregion smooth and opposite side surface of micropin or micropin and foil is recessed, or all or part of region of the both side surface of micropin or micropin and foil all forms recessed row structure as shown in figure 13 to certain direction bending, described groove and projection are the surperficial punching press of foil and micropin one side to be formed recessed, and correspondingly the same position at opposite side forms projection.The hole having on micropin and/or groove structure are all very beneficial for carrying more medicine and can effectively avoid thrusting skin process Chinese medicine and come off in external.Preferably the needle point 4 of micropin has after thrusting and prevents the spearhead shape structure that it exits automatically as a kind of, and described spearhead shape structure comprises the card convex of protruding micropin sidewall.
In a word, metal micro-needle array described in the utility model can adopt the processing technique of existing maturation and package technique to manufacture in batches.
This utility model embodiment provides a kind of microneedle transdermal delivery paster based on above-mentioned metal micro-needle array; it by metal micro-needle array, cover percutaneous patch thereon and protecting film or protective bag and form, percutaneous patch wherein contains one or more ingredient with treatment, health care or effects of beautification and nourishing face or cosmetics and skincare products.As preferably, described percutaneous patch is only covered on the micropin protruding in metal micro-needle array or on needle point, not only can save valuable ingredient like this, and easily controls the dose that enters skin.Groove on micropin and hole not only can be used for storing more medicine, administration time can be more lasting, and in thrusting skin process, can effectively avoid this place's medicine to come off in external problem.Can adopt the multiple conventional physical properties such as dipping, coating, stifling, deposit or chemical method even on substrate, to cover percutaneous administration patch or cosmetic patch at microneedle array.The protecting film adopting or protective bag have sealing and protection micropin and the effect of the percutaneous patch that covers above.
In use, first the microneedle array on microneedle transdermal delivery paster is all thrust to skin, then can this paster be fixed on to skin surface around with common medical adhesive tape.
The microneedle transdermal delivery seal of the above-mentioned metal micro-needle array of application that Figure 18 and Figure 19 provide for this utility model or micropin beauty treatment seal structure cutaway view; described microneedle transdermal delivery seal or micropin beauty treatment seal comprise metal micro-needle array, pedestal 9 and protective cap 12; described metal micro-needle array is permanent or be removably fixed on one end of pedestal 9; the other end of described pedestal 9 has is convenient to manual handle arrangement 10, and described protective cap 12 can be enclosed within on pedestal protects micropin injury-free.
In Figure 18, metal micro-needle array is fixed on the centre of pedestal 9 one end, is provided with bulge-structure 11 and thrusts the degree of depth to limit the maximum of micropin on surrounding pedestal, and the structure of micropin 3 is all not identical with aforementioned each figure yet.The main distinction of Figure 19 and Figure 18 is the shape that is metal micro-needle array, and the shape of their handle arrangement 10 and protective cap 12 is not identical yet in addition.
The micropin roller structure cutaway view of the above-mentioned metal micro-needle array of application that Figure 20 provides for this utility model; described micropin roller comprises metal micro-needle array, the support 13 and protective cap (not shown) of cylindrical shape or cydariform substrate; one end of described support 13 also can make metal micro-needle array freely rotate around it as the axle center support substrates 1 of roller; the other end has is convenient to manual handle arrangement 10, and described protective cap can be enclosed within on support protects micropin injury-free.Support can adopt the multiple materials such as polymer, metal and maturation process to manufacture in batches
This utility model embodiment provides a kind of microneedle electrodes array based on above-mentioned metal micro-needle array, described microneedle electrodes array comprises the external wire that metal micro-needle array is connected with foil with on it, the side of described metal micro-needle array or the back side are provided with the interface being connected with external wire, external lead wire can pass through the modes such as welding, conducting resinl bonding and be connected with interface, described external wire at least has two, but the quantity of no more than foil, can will be set to short circuit or open circuit as required between different metal thin slice.In use, first microneedle array is all thrust to skin, then can the back side of its substrate be fixed on to skin surface around with common medical adhesive tape.Adopt this microneedle electrodes array, not only can effectively improve the signal to noise ratio that bioelectric potential detects, can also to skin, apply the go forward side by side measurement of line correlation of various electrical signal by it.In addition, can also on microneedle electrodes array, apply percutaneous patch, each foil be applied the stimulation of the identical or different signal of telecommunication in microneedle transdermal delivery, may more be conducive to the percutaneous of some drugs to transport to improve curative effect.
The above is only preferred implementation of the present utility model; should be understood that; for those skilled in the art; do not departing under the prerequisite of this utility model know-why; can also make some improvement and replacement, these improvement and replacement also should be considered as protection domain of the present utility model.
Claims (12)
1. a metal micro-needle array, is characterized in that, comprising:
Substrate; With
A foil that is fixed on described substrate surface; And/or
One side is along being embedded in the foil in described substrate;
And/or at least two foils of arranging at a certain distance and being fixed on described substrate surface; And/or
At least two arrange at a certain distance and a side along being embedded in the foil in described substrate; Wherein,
Described foil at least has outwardly microneedle array at the edge of one side, described microneedle array at least comprises two according to the micropin of certain arranged with interval, described micropin protrudes described substrate surface perpendicular or tilt for set angle, and described micropin is vertical or coplanar with the principal plane at the place, central area of described foil, one end of described micropin is needle point.
2. metal micro-needle array according to claim 1, is characterized in that, described substrate is at least comprised of a plane or curved surface thin slice or thin plate, or at least a hollow or solid multiaspect or curved body, consists of.
3. metal micro-needle array according to claim 1, is characterized in that, described substrate adopts a kind of the making in following material: polymer, timber, metal, pottery or glass.
4. metal micro-needle array according to claim 1, is characterized in that, described foil is fixed on described substrate surface by fixed structure and/or adhesive.
5. metal micro-needle array according to claim 1, it is characterized in that, one side edge of described foil is fixed in described substrate by fixed structure and/or adhesive, the surface that the border area of the opposite side of described foil between micropin protrudes recessed or fair substrate.
6. metal micro-needle array according to claim 5, is characterized in that, has locating slot array on described substrate, and a side of described foil is along being embedded in locating slot.
7. metal micro-needle array according to claim 1, it is characterized in that, on the micropin of described foil and/or edge, there is groove or groove and projection, described groove refers to that a side surface subregion smooth and opposite side surface of micropin or micropin and foil is recessed, or the equal and recessed row structures that form crooked to certain direction in all or part of region of the both side surface of micropin or micropin and foil, described groove and projection are the surperficial punching press of foil and micropin one side to be formed recessed, and correspondingly the same position at opposite side forms projection.
8. metal micro-needle array according to claim 1, is characterized in that, the needle point of described micropin has after thrusting and prevents the spearhead shape structure that it exits automatically, and described spearhead shape structure comprises the card convex of protruding micropin sidewall.
9. the microneedle transdermal delivery paster of employing metal micro-needle array as described in claim 1-8 any one; it is characterized in that; described microneedle transdermal delivery paster comprises metal micro-needle array, covers percutaneous patch and protecting film or protective bag thereon; described percutaneous patch contains a kind of ingredient or cosmetics and skincare product with treatment, health care or effects of beautification and nourishing face, and described protecting film or protective bag have the effect of sealing and protection micropin and the percutaneous patch that covers thereof above.
10. the micropin administration seal of employing metal micro-needle array as described in claim 1-8 any one or micropin beauty treatment seal; it is characterized in that; described micropin administration seal or micropin beauty treatment seal comprise metal micro-needle array, pedestal and protective cap; described metal micro-needle array is permanent or be removably fixed on one end of pedestal; the other end of described pedestal has is convenient to manual handle arrangement, and described protective cap can be enclosed within on pedestal protects micropin injury-free.
The micropin roller of 11. 1 kinds of employings metal micro-needle array as described in claim 1-8 any one; it is characterized in that; described micropin roller comprises metal micro-needle array, support and the protective cap of cylindrical shape or cydariform substrate; one end of described support also can make metal micro-needle array freely rotate around it as the axle center support substrates of roller; the other end has is convenient to manual handle arrangement, and described protective cap can be enclosed within on support protects micropin injury-free.
The microneedle electrodes array of 12. 1 kinds of employings metal micro-needle array as described in claim 1-8 any one, it is characterized in that, described microneedle electrodes array comprises the external wire that metal micro-needle array is connected with foil with on it, on the side of described metal micro-needle array and/or the back side, be provided with the interface being connected with external wire, described external wire at least has two, is set to short circuit or open circuit between different metal thin slice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320284037.2U CN203436688U (en) | 2013-05-22 | 2013-05-22 | Metal microneedle array, transdermal delivery patch, microneedle delivery stamp, microneedle cosmetology stamp, microneedle roller and microneedle electrode array |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201320284037.2U CN203436688U (en) | 2013-05-22 | 2013-05-22 | Metal microneedle array, transdermal delivery patch, microneedle delivery stamp, microneedle cosmetology stamp, microneedle roller and microneedle electrode array |
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| CN203436688U true CN203436688U (en) | 2014-02-19 |
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| CN103263727A (en) * | 2013-05-22 | 2013-08-28 | 清华大学 | Metal microneedle array, percutaneous medicine feeding paster, Dermaroller and microneedle electrode array |
| CN105833425A (en) * | 2016-06-08 | 2016-08-10 | 深圳半岛医疗有限公司 | Micro needle assembly and micro needle treatment head |
| CN106806985A (en) * | 2017-01-19 | 2017-06-09 | 汉典生物科技（上海）有限公司 | A kind of beauty micropin roller |
| CN107569767A (en) * | 2017-09-01 | 2018-01-12 | 东莞市睿奇电子科技有限公司 | A kind of micropin and its manufacture method |
| CN109069816A (en) * | 2016-03-16 | 2018-12-21 | 考司美德制药株式会社 | Microneedle patch bracket |
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| CN111073814A (en) * | 2019-12-12 | 2020-04-28 | 北京大学 | Microneedle electrode array device and control method thereof |
| WO2020088371A1 (en) * | 2018-11-02 | 2020-05-07 | 清华大学 | Metal sheet of permeation promotion pen, and roller and permeation promotion pen having metal sheet |
| CN111408047A (en) * | 2020-04-17 | 2020-07-14 | 南京鼓楼医院 | Conductive microneedle patch for wound repair and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014187338A1 (en) * | 2013-05-22 | 2014-11-27 | 清华大学 | Metal microneedle array, transdermal delivery patch, and microneedle transdermal delivery stamp |
| CN103263727A (en) * | 2013-05-22 | 2013-08-28 | 清华大学 | Metal microneedle array, percutaneous medicine feeding paster, Dermaroller and microneedle electrode array |
| CN109069816B (en) * | 2016-03-16 | 2022-03-25 | 考司美德制药株式会社 | Microneedle patch holder |
| CN109069816A (en) * | 2016-03-16 | 2018-12-21 | 考司美德制药株式会社 | Microneedle patch bracket |
| US11484695B2 (en) | 2016-03-16 | 2022-11-01 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch case |
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