JP2015136527A - Microneedle unit - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a microneedle unit which facilitates supply of a liquid body in a microneedle which expresses a function by the supply of the liquid body.SOLUTION: A microneedle unit 10 includes: a liquid body housing part 11 which houses a liquid body and has a supply passage 11b for supplying the liquid body to the outside; a microneedle 31 which has a base body 32 having a surface facing the supply passage 11b and has a projection part 33 on a surface on the opposite side of the surface facing the supply passage 11b of the surfaces of the base body 32; and a pull-out member 21 comprising a plug part for blocking the supply passage 11b and an operational part which is positioned outside the liquid housing part 11 for performing the operation for moving the plug part to open at least a part of the supply passage 11b.

Description

  The technology of the present disclosure relates to a microneedle unit including a microneedle and a microneedle container.

  The percutaneous absorption method is a method in which a substance such as a drug is permeated into the body through the skin, and the substance is administered to the inside of the body without causing pain to the administration subject such as a person. It is a method that can be easily administered to the inside of the body.

  In the percutaneous absorption method, for example, as described in Patent Document 1, a method of administering a drug or the like into the skin by inserting a microneedle into the skin has been proposed. The microneedle includes a protrusion having a size that does not cause pain to the administration target, and the protrusion penetrates the stratum corneum, which is a barrier layer of the skin. And a chemical | medical agent is percutaneously absorbed because a chemical | medical agent is absorbed into the inside of skin from the hole which the microneedle formed in skin.

International Publication No. 2008/020632 Specification

  By the way, when the microneedle absorbs the liquid drug through the hole formed in the skin, first, after the hole is formed in the skin using the microneedle, for example, absorbent cotton containing the liquid material, etc. Is used to supply the drug to the pores. Thus, since it is necessary to prepare a device used for the act of forming a hole in the skin and a device used for the act of supplying a drug to the hole separately, it is easier for the subject. There is a need for microneedles that can exhibit their functions.

  Note that the liquid is not limited to the liquid that is directly supplied to the object to be stabbed by the microneedle, but is, for example, a reaction between the liquid and the microneedle itself, and a liquid that causes the microneedle to exhibit a function through a reaction in which the microneedle dissolves. It is a common problem in the body.

  An object of the technology of the present disclosure is to provide a microneedle unit that facilitates supply of a liquid material in a microneedle that exhibits a function by supplying the liquid material.

  One aspect of the microneedle unit according to the technology of the present disclosure includes a liquid material container having a supply passage for containing a liquid material and supplying the liquid material to the outside, and a base having a surface facing the supply passage. A microneedle having a protrusion on a surface opposite to the surface facing the supply passage among the surfaces of the base, a plug portion blocking the supply passage, and a position outside the liquid material housing portion And an operation unit that performs an operation of moving the plug so as to open at least a part of the supply passage.

  According to one aspect of the microneedle unit in the technology of the present disclosure, the microneedle is stabbed into the object, and at least a part of the supply passage is opened, so that the liquid material in the liquid material container is supplied to the object. Therefore, the liquid material can be supplied to the target in a state where the microneedle is stuck in the target. Therefore, since it is not necessary to prepare another instrument other than the microneedle unit in order to supply the liquid material to the object, it is possible to easily supply the liquid material to the object.

In another aspect of the microneedle unit in the technology of the present disclosure, it is preferable that the forming material of the microneedle is a substance to be dissolved that is dissolved in the liquid.
According to another aspect of the microneedle unit in the technology of the present disclosure, the microneedle can be dissolved by the microneedle touching the liquid material. Then, the dissolved microneedle forming material and the liquid are supplied to the target.

As for the other aspect of the microneedle unit in the technique of this indication, it is preferable that the said liquid body contains a chemical | medical agent.
According to the microneedle unit in the technology of the present disclosure, the liquid includes a drug to be administered to the skin. Here, in general, when a drug is administered to a subject using a microneedle, the configuration in which the liquid contained in the microneedle contains the drug is compared to the configuration in which the protrusion of the microneedle contains the drug. It may be possible to increase the dose of the drug. That is, according to the above-mentioned aspect, compared with the structure in which the projection part of the microneedle contains a drug, at least the same or more drug is administered to the subject.

  According to another aspect of the microneedle unit in the technology of the present disclosure, the microneedle is a through-hole that penetrates the microneedle in a direction in which the liquid material container and the microneedle face each other, and the microneedle is When the microneedle is stabbed by an object to be stabbed and at least a part of the supply passage is opened, it is preferable to have the through-hole that connects the interior of the liquid material container and the object.

According to another aspect of the microneedle unit in the technology of the present disclosure, the liquid material is supplied to the target through the through hole of the microneedle.
In another aspect of the microneedle unit according to the technology of the present disclosure, a surface that faces the supply passage is a facing surface among surfaces that the base has, and a surface on which the protrusion is located is a surface that the base has. A protrusion-forming surface, and a portion of the protrusion-forming surface where the protrusion is formed is a protrusion-forming portion, and the protrusion-forming portion and the supply passage are opposed to each other across the facing surface. preferable.

  According to the other aspect of the microneedle unit in the technology of the present disclosure, the liquid material is easily supplied to the protrusion portion of the microneedle that is pierced by the object. Therefore, the liquid material is easily supplied to the target.

  Another aspect of the microneedle unit according to the technology of the present disclosure includes the liquid material storage portion including a concave container that stores the liquid material, and a sealing portion having a plate shape that closes an opening of the concave container. The sealing portion has the supply passage, and a portion of the surface of the sealing portion that faces the facing surface, except for a portion where the supply passage is located, extends from the facing surface to the facing surface. It is preferable to further include an adhesive portion extending around the opposing surface.

  According to another aspect of the microneedle unit in the technology of the present disclosure, when the microneedle is stabbed into the object, the adhesive portion contacts a portion of the object that is located around the base. Therefore, when the microneedle is stabbed into the object, the position of the microneedle with respect to the object is easily maintained.

  According to the microneedle unit in the technique of the present disclosure, it is possible to easily supply the liquid material to the skin where the microneedle is pierced.

It is a disassembled perspective view which shows the perspective structure which decomposed | disassembled the microneedle unit in 1st Embodiment which actualized the microneedle unit of this indication. It is sectional drawing which shows the cross-section of the microneedle unit in 1st Embodiment. It is sectional drawing which shows the cross-section of the microneedle unit in 1st Embodiment. It is a fragmentary sectional view which shows the partial cross-section containing a microneedle among the cross-sections of the microneedle unit in 1st Embodiment. It is an operation view for explaining the operation of the microneedle unit in the first embodiment. It is an operation view for explaining the operation of the microneedle unit in the first embodiment. It is an operation view for explaining the operation of the microneedle unit in the first embodiment. It is a disassembled perspective view which shows the perspective structure which decomposed | disassembled the microneedle unit in 2nd Embodiment which actualized the microneedle unit of this indication. It is sectional drawing which shows the cross-section of the microneedle unit in 2nd Embodiment. It is an effect | action figure for demonstrating the effect | action of the microneedle unit in 2nd Embodiment.

[First Embodiment]
A first embodiment in which the microneedle unit of the present disclosure is embodied will be described with reference to FIGS. 1 to 7. Below, the whole structure of a microneedle unit, the structure of a microneedle, the formation material of a microneedle, and the effect | action of a microneedle unit are demonstrated in order.

[Overall configuration of microneedle unit]
The entire configuration of the microneedle unit will be described with reference to FIGS. 2 and 3 are cross-sectional views showing a cross-sectional structure along a plane perpendicular to the sealing portion 13 and passing through the liquid storage portion, the drawing member, the adhesive portion, and the microneedle.

  As shown in FIG. 1, the microneedle unit 10 includes a liquid material storage unit 11, microneedles 31, and a drawing member 21. The liquid material container 11 has a supply passage 11b for accommodating the liquid material and supplying the liquid material to the outside.

  The microneedle 31 includes a base 32 having a surface facing the supply passage 11b, and has a protrusion 33 on a surface opposite to the surface facing the supply passage 11b among the surfaces of the base 32. The drawing member 21 includes a plug portion that closes the supply passage 11b and an operation portion that is located outside the liquid material storage portion 11 and is operated to move the plug portion so as to open at least a part of the supply passage 11b. Is done.

  The liquid material accommodating part 11 includes a concave container 12 and a sealing part 13 that closes the opening 12a of the concave container 12, and forms an accommodating space 11a for accommodating the liquid material. The concave container 12 has a cylindrical shape having a bottom, and the concave container 12 includes a cylindrical body 12b having a cylindrical shape and a bottom portion 12c positioned at one of the two cylindrical ends of the cylindrical body 12b. Yes. Alternatively, the concave container 12 may have a hemispherical shape or a semi-ellipsoidal shape. The sealing part 13 may have a disk shape, and the sealing part 13 may have a plate shape other than the disk shape.

  The concave container 12 includes a flange portion 12d extending from the opening 12a of the concave container 12 toward the radially outer side of the cylindrical body 12b. The diameter of the sealing portion 13 is the diameter of the cylindrical body 12b including the flange portion 12d. That's it. In the liquid material accommodating part 11, since the concave container 12 is provided with the flange part 12d, compared with the structure which is not provided with the flange part 12d, the area which the concave container 12 and the sealing part 13 contact is enlarged. Can do. Therefore, the liquid material accommodated in the accommodating space 11 a of the liquid material accommodating portion 11 is less likely to leak to the outside from the gap between the concave container 12 and the sealing portion 13.

  The liquid material accommodated in the accommodation space 11a only needs to have fluidity that can flow out from the inside of the accommodation space 11a through the supply passage 11b of the liquid material accommodation portion 11. Therefore, the liquid may be a liquid, a colloidal solution, a gel, or the like. In the accommodation space 11a, the liquid material may be located in the entire accommodation space 11a, or the liquid material may be located in a part of the accommodation space 11a.

The liquid material containing part 11 has a supply passage 11 b on the surface of the sealing part 13 facing the microneedles 31.
The supply passage 11b penetrates a part of the wall portion constituting the liquid material accommodating portion 11 along the direction in which the liquid material accommodating portion 11 and the microneedle 31 face each other. The supply passage 11 b has a linear shape extending from the outer edge of the sealing portion 13 toward the inside of the sealing portion 13. In the supply passage 11b, the length L1 is smaller than the diameter of the sealing portion 13. In the supply passage 11b, the length along the direction orthogonal to the length L1 is the length L2.

  The drawing member 21 has a plate shape that closes the supply passage 11 b of the liquid material containing portion 11. When the supply passage 11b of the liquid material containing portion 11 has a rectangular shape in plan view, the drawing member 21 has a rectangular plate shape. In the drawing member 21, when the drawing member 21 closes the supply passage 11b, the length L3 in the direction from the inside toward the outer edge of the sealing portion 13 is larger than the length L1 of the supply passage 11b. Thereby, when the drawing member 21 closes the supply passage 11b, a part of the drawing member 21 protrudes outside the outer edge of the flange portion 12d of the concave container 12. Therefore, when the user pulls out the drawing member 21 from the supply passage 11b, the user can grip a portion of the drawing member 21 that protrudes outside the outer edge of the flange portion 12d. Therefore, the drawer member 21 is easily pulled out.

  In the drawing member 21, the length L4 along the direction orthogonal to the length L3 is substantially equal to the length L2 of the supply passage 11b. Therefore, when the drawing member 21 is positioned inside the supply passage 11b, the liquid material stored in the storage space 11a does not leak to the outside of the storage space 11a.

The drawing member 21 has a plug portion that is a portion that blocks the supply passage 11 b and an operation portion that protrudes outside the liquid material housing portion 11.
In the drawing member 21, when the operating portion is pulled by the user, the position of the drawing member 21 with respect to the supply passage 11b changes. Thereby, the position of the drawing member 21 is changed from a closed position where the drawing member 21 closes the entire supply passage 11b to an open position where at least a part of the supply passage 11b is opened.

  The sealing part 13 has the adhesion part 41 in the surface which opposes the opposing surface 32b which is one surface of the microneedle 31 among the surfaces which the sealing part 13 has. At this time, the adhesion part 41 spreads from the facing surface 32b of the microneedle 31 to the periphery of the facing surface 32b in a portion excluding the portion where the supply passage 11b is located in the surface facing the microneedle 31 in the sealing portion 13. .

  In order to increase the adhesive strength of the adhesive portion 41, the adhesive portion 41 is preferably located on the entire surface of the sealing portion 13 that faces the opposing surface 32b except for the portion where the supply passage 11b is located.

  That is, the adhesive part 41 has an adhesive supply passage 41 a that penetrates the adhesive part 41 in the direction in which the liquid material containing part 11 and the microneedle 31 face each other. When viewed from the direction in which the liquid container 11 and the microneedle 31 face each other, the position of the adhesive supply passage 41a overlaps the position of the supply passage 11b.

  In the adhesive supply passage 41a, the length L5 along the direction in which the drawing member 21 in the sealing portion 13 is drawn out is preferably substantially equal to the length L1 in the supply passage 11b. What is the direction in which the drawing member 21 is drawn out? The length L6 in the orthogonal direction is substantially equal to the length L2 in the supply passage 11b.

  The microneedle 31 includes a base body 32 and one or more protrusions 33. The base 32 of the microneedle 31 has a disk shape, and may have a polygonal plate shape such as a rectangular plate shape, for example. Of the surfaces of the base 32, the surface on which the protrusion 33 is positioned is the protrusion forming surface 32a, and the surface opposite to the protrusion forming surface 32a is the facing surface 32b. Of the projection forming surface 32a, the region where the projection 33 is located is the projection forming portion 32a1. The facing surface 32 b of the microneedle 31 is bonded to the adhesive portion 41.

  The protrusion forming portion 32a1 of the base 32 in the microneedle 31 faces the supply passage 11b with the opposing surface 32b interposed therebetween. Therefore, the liquid material accommodated in the liquid material accommodating portion 11 is easily supplied to the protrusion 33 stabbed by the target in the microneedle 31. Therefore, the liquid material is easily supplied to the target.

  The area of the protrusion forming surface 32a on the base body 32 may be equal to or larger than the area where one or more protrusions 33 can be located. The protrusion forming surface 32a of the base body 32 has a planar shape. The protrusion forming surface 32a may have a curved surface shape, or may have both a planar shape and a curved surface shape. The facing surface 32b of the base body 32 has a planar shape. The facing surface 32b may have a curved surface shape, similar to the protrusion forming surface 32a, or may have both a planar shape and a curved surface shape.

  The microneedle 31 has a plurality of protrusions 33 on the protrusion forming surface 32a, and the plurality of protrusions 33 are arranged in a lattice pattern. The plurality of protrusions may be arranged irregularly, or may be arranged according to a rule other than a lattice shape, such as a close-packed state or a concentric circle shape.

  The protrusion 33 has a conical shape extending along the extending direction which is one direction. The protrusion 33 may have a cone shape other than the cone shape, a frustum shape, or a columnar shape. When the protrusion 33 has a cone shape other than the conical shape, the protrusion 33 only needs to have a polygonal pyramid shape. When the protrusion 33 has a frustum shape, the protrusion 33 has a truncated cone shape. Or what is necessary is just to have a polygon frustum shape. When the protrusion 33 has a columnar shape, the protrusion 33 only needs to have a cylindrical shape or a polygonal column shape.

  Further, the protrusion 33 may have two or more shapes that are different from each other in the extending direction. In this case, the protrusion 33 is included in the cone shape, the frustum shape, and the column shape described above. What is necessary is just to have two or more shapes. The outer peripheral surface of the protrusion 33 may have a twist or a step. In order for each protrusion 33 to pierce the target, at least the tip of the protrusion 33 preferably has a cone shape.

  Each of the plurality of protrusions 33 has the same shape. Alternatively, each of the plurality of protrusions 33 may have a different shape. In order to facilitate the formation of the plurality of protrusions 33, it is preferable that each of the plurality of protrusions 33 have the same shape.

  Each of the plurality of protrusions 33 extends along the same direction. Note that each of the plurality of protrusions 33 may extend along a direction intersecting each other. When each of the plurality of projecting portions 33 extends along a direction intersecting with each other, the extending direction of each projecting portion 33 is a direction in which the tip of each projecting portion 33 is not in contact with the tips of the other projecting portions 33. Preferably, each of the tips of the plurality of protrusions 33 is preferably located on the same plane. Thereby, each front-end | tip of the some projection part 33 becomes easy to stab an object.

Each of the plurality of protrusions 33 has the same length in the extending direction. Alternatively, each of the plurality of protrusions 33 may have different lengths in the extending direction.
The microneedle 31 may have one protrusion 33 on the protrusion formation surface 32a of the base 32. In this case, the protrusion 33 may be located at the center of the protrusion formation surface 32a. It may be located at any part other than the center.

  As shown in FIG. 2, the sealing portion 13 is two surfaces extending along the direction in which the drawing member 21 is drawn out of the surfaces constituting the supply passage 11 b, and two surfaces facing each other. Each has a fitting groove 13a. Each fitting groove 13a is recessed from the surface on which each fitting groove 13a is located toward the outer edge of the sealing portion 13, and each fitting groove 13a extends over the entire direction in which the drawing member 21 is drawn on each surface. positioned. In each fitting groove 13a, the shape in the cross section along the direction where the liquid body accommodating part 11 and the microneedle 31 oppose is a rectangular groove shape.

  On the other hand, the pull-out member 21 is two surfaces extending along the pull-out direction of the pull-out member 21, and fitting protrusions 21 a that protrude toward the outer sides of the two surfaces facing each other in the pull-out member 21. Have Each fitting protrusion 21a is located over the entire direction in which the drawing member 21 is pulled out on the surface where each of the fitting protrusions 21a is located. In each fitting protrusion 21a, the shape in the cross section along the direction in which the liquid container 11 and the microneedle 31 face each other is substantially equal to the shape of the fitting groove 13a in which each fitting protrusion 21a is fitted.

  In the microneedle unit 10, the drawing member 21 blocks the supply passage 11 b, thereby sealing between the surface of the supply passage 11 b that contacts the drawing member 21 and the surface of the drawing member 21 that contacts the supply passage 11 b. The Therefore, the liquid material 51 accommodated in the liquid material accommodating portion 11 is stored in the liquid material through a gap between the surface of the supply passage 11b that contacts the drawing member 21 and the surface of the extraction member 21 that contacts the supply passage 11b. It becomes difficult to leak outside the portion 11.

  Moreover, since the weight of the liquid 51 and the weight of the drawing member 21 are supported by the sealing portion 13, the load applied to the microneedles 31 is reduced. Therefore, even if the adhesive force between the microneedle 31 and the adhesive portion 41 is small as compared with the configuration without the fitting groove and the fitting protrusion, the microneedle 31 is prevented from peeling off from the adhesive portion 41.

  In such a microneedle unit 10, the microneedle 31 is inserted into the object, and the position of the pull-out member 21 is changed from the closed position to the open position by the user, so that the microneedle 31 is a liquid material in the liquid material storage unit 11. The liquid material 51 that has come out of the container 11 is supplied to the target.

  For this reason, for example, the material for forming the microneedles 31 is preferably a material that is biocompatible and dissolves in the liquid contained in the liquid containing part 11. The material having biocompatibility is a material that exhibits the function as the microneedle 31 and does not negatively affect the target to which the microneedle 31 is applied.

  When the forming material of the microneedles 31 is a material that dissolves in a liquid, the forming material is, for example, a water-soluble polymer. Examples of the water-soluble polymer include alginate, curdlan, chitin, chitosan, glucomannan, polymalic acid, collagen, collagen peptide, hydroxypropylcellulose, hydroxypropylmethylcellulose, gelatin and the like.

  In the microneedle 31, the forming material of the base body 32 and the forming material of the protrusion 33 may be the same as each other or different from each other. Moreover, in the microneedle 31, the formation material in each of the some projection part 33 may mutually be the same, and may differ.

  The liquid 51 may be a liquid that can dissolve the microneedles 31 formed of a water-soluble polymer, and includes, for example, an aqueous solvent such as water or ethyl alcohol. The liquid 51 may be a liquid that can dissolve the microneedles 31 and that contains a liquid drug administered to the skin or a liquid drug dissolved in a predetermined solvent.

  The drug administered to the skin is a pharmacologically active substance or a cosmetic composition. When the drug is a pharmacologically active substance, the drug is appropriately selected according to the use of the user. When the drug is a pharmacologically active substance, the drug is, for example, a vaccine such as influenza, an anti-pain drug used by cancer patients, insulin, a biologic, a gene therapy drug, an injection, an oral preparation, and a skin application preparation. is there.

  Since the microneedle unit 10 is stabbed into the skin, transdermal administration using the microneedle unit 10 is not limited to pharmacologically active substances that have been conventionally used for transdermal administration. Also applies. In particular, even when a vaccine, which is an injection, is administered, according to the transdermal administration using the microneedle unit 10, there is no pain when the drug is administered. Therefore, transdermal administration using the microneedle unit 10 is preferably applied to children. Further, according to the transdermal administration by the microneedle unit 10, when the drug is administered to the patient, the patient does not need to take the drug. Therefore, it is preferable that the microneedle unit 10 is applied to a child who is difficult to take an oral preparation.

  The cosmetic composition is a composition used as a cosmetic and a cosmetic, and when the drug is a cosmetic composition, the drug includes, for example, a moisturizer, a colorant, a fragrance, and a physiologically active substance exhibiting a cosmetic effect. It is. Examples of the active substance exhibiting a cosmetic effect include a substance having an effect of improving wrinkles, acne and pregnancy lines, and a substance having an effect of improving hair loss.

  Moreover, the forming material of the protrusion 33 may include the above-described drug. In this case, both the liquid 51 and the protrusion 33 may include the above-described drug, or only the protrusion 33 may include the above-described drug. Alternatively, the material for forming the protrusion 33 may be a material that dissolves inside the target skin. In this case, the liquid accommodated in the liquid material accommodating portion 11 increases the speed at which the protrusion 33 is dissolved in the skin.

  In addition, it is preferable that the liquid body 51 accommodated in the microneedle unit 10 contains a chemical | medical agent. According to the microneedle unit 10 in which the liquid 51 includes a drug, there may be a case where the dose of the drug to the target can be increased as compared with the configuration in which the protrusion 33 of the microneedle 31 includes the drug. That is, when the protrusion 33 of the microneedle 31 contains a drug, there is an upper limit on the amount that the microneedle 31 can contain the drug from the viewpoint of the strength required for the microneedle 31. On the other hand, when the liquid 51 contains a drug, the drug may be dissolved or dispersed in the liquid 51. In general, the volume of the liquid 51 is the protrusion 33 of the microneedle 31. Larger than the volume of. Therefore, the liquid 51 can contain a larger amount of medicine than the upper limit amount of medicine that the microneedle 31 can contain.

  Thus, since the forming material of the microneedle 31 is a substance to be dissolved that dissolves in the liquid body 51, the microneedle 31 can be dissolved by the microneedle 31 touching the liquid body 51. And the forming material of the melt | dissolved microneedle 31 and the liquid 51 are supplied to object.

  Alternatively, as shown in FIG. 3, the microneedle 31 may have a through-hole 32 c that penetrates the microneedle 31 in a direction in which the liquid material storage unit 11 and the microneedle 31 face each other. The through-hole 32c connects the accommodation space 11a of the liquid material 51 in the liquid material accommodating part 11 and the object when the microneedle 31 is pierced by the object and the drawing member 21 opens at least a part of the supply passage 11b. Thereby, the through-hole 32c supplies the liquid material that has come out of the storage space 11a from the supply passage 11b of the liquid material storage portion 11 to the target.

  The microneedle 31 has a plurality of through holes 32c. The number of through-holes 32c that the microneedle 31 has may be one. The through-hole 32c penetrates the base body 32 of the microneedle 31 in the direction in which the microneedle 31 and the liquid material storage unit 11 face each other. The through-hole 32c may penetrate both the base body 32 and the protrusion 33 in the direction in which the microneedle 31 and the liquid material storage unit 11 face each other.

  In the configuration in which the microneedle 31 has the through-hole 32 c, the material for forming the microneedle 31 may be a material that dissolves in the liquid 51 described above, or a material that dissolves in the liquid 51. It may be a material that does not. When the forming material of the microneedle 31 is a material that does not dissolve in the liquid 51, the forming material is, for example, silicon, metal, resin, or the like. When the forming material of the microneedle 31 is a metal, the forming material is stainless steel, titanium, manganese, or the like. When the forming material of the microneedles 31 is a resin, the forming material is, for example, medical silicone, polylactic acid, polyglycolic acid, polycarbonate, and cyclic olefin copolymer.

  In the microneedle 31, the forming material of the base body 32 and the forming material of the protrusion 33 may be the same as each other or different from each other. Moreover, in the microneedle 31, each forming material of the some projection part 33 may mutually be the same, and may differ.

  When the microneedle 31 is a material that does not dissolve in the liquid 51, the liquid 51 is a liquid containing the liquid medicine administered to the skin or the liquid medicine dissolved in a predetermined solvent. I just need it.

[Configuration of microneedle]
The configuration of the microneedle 31 will be described with reference to FIG.
As shown in FIG. 4, in the protrusion 33 of the microneedle 31, the height H of the protrusion 33 is a length along the extending direction, and from the protrusion formation surface 32 a of the base body 32 to the protrusion 33. This is the length to the tip that is the end away from the substrate 32. The protrusion 33 preferably has a height H suitable for forming a hole in the target skin, and the height H of the protrusion 33 is preferably included in the range of 10 μm to 1000 μm.

  The height H of the protrusion 33 is preferably set according to which part of the skin is located at the bottom of the hole formed in the subject. When the position of the bottom of the hole is set inside the stratum corneum, the height H of the protrusion 33 is preferably included in the range of 10 μm to 300 μm, and may be included in the range of 30 μm to 200 μm. More preferred.

  When the position of the bottom of the hole is set at a position that penetrates the stratum corneum in the skin and does not reach the nerve layer, the height H of the protrusion 33 is preferably included in the range of 200 μm to 700 μm. And more preferably in the range of 200 μm or more and 500 μm or less. When the position of the bottom of the hole is set to a position that penetrates the stratum corneum in the skin and does not reach the nerve layer, the height H of the protrusion 33 is further included in the range of 200 μm to 300 μm. preferable.

  When the position of the bottom of the hole is set to a position that reaches the dermis, the height H of the protrusion 33 is preferably included in the range of 200 μm to 500 μm. When the position of the bottom of the hole is set to a position that reaches the epidermis, the height H of the protrusion 33 is preferably included in the range of 200 μm to 300 μm.

  In the protrusion 33, the maximum value in the length in the direction orthogonal to the extending direction is the width D, and the width D of the protrusion 33 is preferably included in the range of 1 μm to 300 μm. For example, when the projecting portion 33 has a regular quadrangular pyramid shape or a regular quadrangular prism shape, the base end, which is an end portion different from the distal end of the projecting portion 33, defines a square area on the projecting surface 32a. The length of the diagonal line in the square area defined by the base end of the protrusion 33 is the width D of the protrusion 33. Further, for example, when the protrusion 33 has a conical shape or a cylindrical shape, the base end of the protrusion 33 defines a circular region on the protrusion forming surface 32a. The diameter of the circular region defined by the base end of the protrusion 33 is the width D of the protrusion 33.

In the protrusion 33, the aspect ratio A is the ratio of the height H to the width D (A = H / D). The aspect ratio of the protrusion 33 is preferably included in the range of 1 or more and 10 or less.
When the protrusion 33 has a cone shape at least at the tip, in the protrusion 33, the angle at the tip is the tip angle θ, and the tip angle θ is a cross section along the direction orthogonal to the protrusion forming surface 32a of the base body 32. The maximum value of the angle formed by the protrusion 33. For example, when the projection 33 has a regular quadrangular pyramid shape, the tip angle θ of the projection 33 is the top of an isosceles triangle with the diagonal line at the base end of the projection 33 as the base and the tip of the projection 33 as the apex. It is a horn.

  When the projection 33 has a cone shape at least at the tip, and the position of the bottom of the hole is set to a position penetrating the stratum corneum, the tip angle θ is included in the range of 5 ° to 30 °. It is preferable that it is contained in the range of 10 ° or more and 20 ° or less.

[Component material of microneedle unit]
The material for forming the microneedles 31 may be any one of the materials described above, and the liquid 51 contained in the liquid material storage unit 11 may be any one of the liquids described above.

  In addition, the manufacturing method of the microneedle 31 may be any of various known methods. When the forming material of the microneedles 31 is a resin, the manufacturing method of the microneedles 31 is any one of an injection molding method, an extrusion molding method, an imprint method, a hot embossing method, a casting method, and the like.

  When the forming material of the microneedle 31 is silicon or metal, the manufacturing method of the microneedle 31 may be any one of a machining method such as a cutting method and an etching method.

  Regardless of the material for forming the microneedles 31, the method for manufacturing the microneedles 31 may be a method of duplicating using an intaglio plate using the microneedles 31 as an original plate. The intaglio is produced by, for example, a plating method or a mold making method using a resin.

  When the liquid material containing part 11 includes the concave container 12 and the sealing part 13, the forming material of the concave container 12 is preferably a flexible material, and the forming material of the concave container 12 is, for example, polyethylene. , Polypropylene, and resins such as polyethylene terephthalate. The material for forming the sealing portion 13 is preferably a flexible material, and the material for forming the sealing portion 13 is, for example, a resin such as polyethylene, polypropylene, and polyethylene terephthalate, like the concave container 12. is there. The material for forming the drawing member 21 is the same as the material for forming the sealing portion 13.

  When the microneedle unit 10 has the adhesive part 41, the forming material of the adhesive part 41 is, for example, a polyurethane material, an acrylic material, a polyvinyl chloride material, a polyvinylidene chloride material, a vinyl acetate material, and silicone. Adhesive materials such as system materials.

[Operation of microneedle]
The operation of the microneedle unit will be described with reference to FIGS.
As shown in FIG. 5, when the microneedle unit 10 is used, the user first places the microneedle unit 10 on the target skin in a state where the protrusion forming surface 32 a of the microneedle 31 faces the target skin S. Put on S. And a user gives the force pressed toward the object with respect to the liquid substance accommodating part 11 of the microneedle unit 10. FIG. As a result, the protrusion 33 of the microneedle 31 pierces the target skin S, and the protrusion 33 forms a hole in the skin S.

  As shown in FIG. 6, the user picks the operation portion which is a portion protruding outward in the radial direction from the flange portion 12 d of the concave container 12 in the pull-out member 21, and plugs the plug portion of the pull-out member 21 into the sealing portion 13. Pull out toward the outside in the radial direction. Thereby, for example, the whole drawing member 21 is drawn to the outside of the liquid material containing portion 11, and the drawing member 21 with respect to the supply passage 11b of the sealing portion 13 opens the whole supply passage 11b. The supply passage 11 b connects the accommodation space 11 a of the liquid material accommodation unit 11 and the facing surface 32 b of the microneedle 31.

  Therefore, as shown in FIG. 7, the liquid 51 located inside the accommodation space 11a is supplied to the facing surface 32b of the microneedle 31 through the supply passage 11b. At this time, the liquid 51 exiting from the inside of the liquid container 11 does not leak out of the concave container 12 due to its own surface tension. When the microneedle 31 is a substance to be dissolved that dissolves in the liquid body 51, the microneedle 31 is dissolved by the liquid body 51 and the microneedle 31 coming into contact with each other. Thereby, the liquid 51 and the material for forming the microneedle 31 dissolved in the liquid 51 are supplied into the target skin S through the holes formed in the skin S by the protrusions 33.

  On the other hand, when the microneedle 31 is a substance that does not dissolve in the liquid material 51 and the microneedle 31 has the through-hole 32c, the liquid material 51 positioned inside the accommodation space 11a passes through the supply passage 11b. To the opposite surface 32b. And the liquid body 51 moves toward the object from the facing surface 32b of the microneedle 31 through the through hole 32c of the microneedle 31. Thereby, the microneedle 31 supplies the liquid 51 to the object.

  Thus, according to the microneedle unit 10, the protrusion 33 of the microneedle 31 is stabbed into the object, and the position of the drawing member 21 with respect to the supply passage 11b is changed to a position where at least a part of the supply passage 11b is opened. As a result, the liquid material 51 in the liquid material container 11 is supplied to the target. Therefore, since it is not necessary to prepare another instrument other than the microneedle unit 10 in order to supply the liquid material 51 to the target, it is possible to easily supply the liquid material 51 to the target.

[Example]
[Manufacturing method of microneedle]
When manufacturing the microneedles 31, first, an original plate of the microneedles 31 was prepared from a silicon substrate by precision machining. On the silicon substrate, 36 regular quadrangular pyramidal projections were formed. In each projection, the height H was set to 150 μm, and the length of one side on the bottom surface was set to 60 μm. Each of the 36 protrusions was formed with an interval of 1 mm between each other, and was arranged in a grid of 6 columns and 6 rows.

  Next, a nickel film having a thickness of 500 μm was formed on the original plate of the microneedle 31 formed from a silicon substrate by a plating method. When the nickel film was formed, the original plate was removed by wet etching using a 30% by weight potassium hydroxide aqueous solution heated to 90 ° C. to produce an intaglio plate made of nickel.

  When the intaglio was prepared, liquid hydroxypropylcellulose was supplied to the intaglio and the hydroxypropylcellulose was solidified by heating with a heat source. The microneedle 31 was obtained by removing the solidified hydroxypropyl cellulose from the intaglio.

[Manufacturing method of microneedle unit]
As the concave container 12 of the microneedle unit 10, a polyethylene terephthalate (PET) container having a cylindrical shape in which one of two cylindrical ends is closed was used. In addition, a PET resin film having a disk shape having the supply passage 11 b was used as the sealing portion 13, and a PET resin member having a rectangular column shape was used as the extraction member 21. An acrylic adhesive material was used as a material for forming the adhesive portion 41.

  The inside of the concave container 12 is filled with a 0.1% rhodamine aqueous solution, while the extraction member 21 is positioned at a closed position with respect to the supply passage 11b of the sealing portion 13 and faces the microneedles 31 in the sealing portion 13. The adhesive part 41 was affixed on the surface to perform. And the opening part 12a of the concave container 12 was block | closed with the sealing part 13 by adhere | attaching between the flange part 12d and the sealing part 13 of the concave container 12 using an adhesive agent.

  Next, the microneedle 31 was affixed to the adhesive portion 41 in a state where the protrusion forming portion 32a1 of the base 32 and the supply passage 11b of the microneedle 31 overlap each other with the opposing surface 32b of the base 32 interposed therebetween.

[Confirmation test and test results]
By placing the microneedle unit 10 obtained by the above-described method on the skin of a pig and pressing the microneedle unit 10 against the skin, the protrusion 33 of the microneedle 31 is pierced into the skin. And in the state which stabbed the protrusion part 33 in the skin, the drawing-out member 21 was pulled out and left still for 5 minutes.

  When the microneedle unit 10 was removed from the pig skin, and the portion of the pig skin where the protrusion 33 of the microneedle 31 was stuck was observed with a confocal microscope, rhodamine fluorescence was observed inside the skin. That is, according to the microneedle unit 10, it was recognized that the liquid 51 was supplied into the skin of the target pig by dissolving the microneedles 31 in the liquid 51.

As described above, according to the microneedle unit of the first embodiment, the effects listed below can be obtained.
(1) The microneedles 31 are pierced by the object, and the drawing member 21 is drawn to a position where at least a part of the supply passage 11b is opened, whereby the liquid material 51 in the liquid material container 11 is supplied to the object. Therefore, the liquid 51 can be supplied to the target with the microneedle 31 stuck in the target. Therefore, since it is not necessary to prepare another device other than the microneedle unit 10 in order to supply the liquid material 51 to the object, the liquid material 51 can be easily supplied to the object.

  (2) When the forming material of the microneedle 31 is a substance to be dissolved that dissolves in the liquid body 51, the microneedle 31 can be dissolved by the microneedle 31 touching the liquid body 51. And the forming material of the melt | dissolved microneedle 31 and the liquid 51 are supplied to object.

  (3) When the microneedle 31 has the through hole 32c, the liquid 51 is supplied to the target through the through hole 32c of the microneedle 31. Therefore, since the material for forming the microneedles 31 does not have to be a material that dissolves in the liquid 51, the degree of freedom in the material for forming the microneedles 31 is increased.

  (4) Since the supply passage 11b and the protrusion forming portion 32a1 face each other across the facing surface 32b, the liquid material 51 is easily supplied to the protrusion 33 stabbed by the target in the microneedle 31. Therefore, the liquid 51 is easily supplied to the target.

  (5) In the configuration in which the microneedle unit 10 includes the adhesive portion 41, when the microneedle 31 is stabbed into the target, the adhesive portion 41 contacts a portion of the target that is located around the base body 32. Therefore, when the microneedle 31 is stabbed into the object, the position of the microneedle 31 with respect to the object is easily maintained.

The first embodiment described above can be implemented with appropriate modifications as follows.
-The microneedle unit 10 does not need to have the adhesion part 41. FIG. In such a configuration, the facing surface 32b of the base body 32 may be bonded to the sealing portion 13 with an adhesive, for example. Even if the microneedle unit 10 does not have the adhesive portion 41, the effects according to the above (1) to (4) can be obtained.

  The supply passage 11b of the sealing portion 13 and the protrusion forming portion 32a1 of the base body 32 do not have to face each other across the facing surface 32b. For example, the supply passage 11b of the sealing portion 13 may be configured to face the portion of the protrusion forming surface 32a of the base body 32 where the protrusion 33 is not formed, with the opposing surface 32b interposed therebetween. Even with such a configuration, it is possible to obtain the effects according to the above-described (1), (2), (4), and (5).

-The liquid material accommodating part 11 may be comprised from one member, for example, a bag body, and may form the accommodating space 11a inside.
The sealing part 13 may have one supply passage 11b or a plurality of supply passages 11b. When the sealing portion 13 has a plurality of supply passages 11 b, at least a part of each supply passage 11 b only needs to face the base body 32 in the microneedle 31. Moreover, when the sealing part 13 has the several supply channel | path 11b, the microneedle unit 10 should just have the drawer member corresponding to each supply channel | path 11b.

  -The fitting groove 13a of the sealing part 13 does not need to be located over the whole, and the sealing part 13 does not need to have the fitting groove 13a. Moreover, the shape of the cross-section mentioned above in the fitting groove 13a of the sealing part 13 may not be rectangular shape, for example, semicircular shape etc. may be sufficient. In such a configuration, the shape of the fitting protrusion 21a of the drawing member 21 may be changed as appropriate according to the shape of the fitting groove 13a.

-While the sealing part 13 has a fitting protrusion, the structure which the extraction | drawer member 21 has a fitting groove | channel may be sufficient.
The liquid material 51 accommodated in the liquid material accommodating portion 11 may be supplied to the target by pressing the bottom portion 12c of the liquid material accommodating portion 11 toward the target. In such a configuration, if the entire drawing member 21 is pulled out from the liquid material container 11, the liquid material 51 supplied from the supply passage 11 b toward the target may leak around the concave container 12. Get higher.

  Therefore, in such a configuration, for example, it is preferable that the drawing member 21 has a locking portion that extends in a direction in which the liquid material containing portion 11 and the microneedle 31 face each other at an end portion located inside the sealing portion 13. . In the configuration in which the drawing member 21 has a locking portion, the drawing member 21 is locked by the locking portion abutting against the cylindrical body 12b of the concave container 12. For this reason, the liquid material containing portion 11 is not pulled out from the entire drawing member 21. Thereby, it is suppressed that the liquid 51 leaks around the concave container 12.

[Second Embodiment]
A second embodiment in which the microneedle unit of the present disclosure is embodied will be described with reference to FIGS. 8 to 10. Note that the microneedle unit of the second embodiment differs from the microneedle unit of the first embodiment in the configuration related to the plug portion. Therefore, in the following, such differences will be described in detail, and the overall configuration of the microneedle unit and the operation of the microneedle unit will be described in order while omitting the detailed description of other configurations. Moreover, in FIG. 8 to FIG. 10, the same reference numerals are given to the configurations equivalent to the configurations of the microneedle unit of the first embodiment.

[Overall configuration of microneedle unit]
The entire configuration of the microneedle unit will be described with reference to FIGS.
As shown in FIG. 8, the microneedle unit 60 includes a liquid material storage unit 11, a microneedle 31, and a drawing member 63, and the liquid material storage unit 11 includes a concave container 12 and an opening 12 a of the concave container 12. The sealing part 13 which seals is provided. The microneedle unit 10 has an adhesive portion 41 between the liquid material housing portion 11 and the microneedle 31 in the direction in which the liquid material housing portion 11 and the microneedle 31 face each other.

  The liquid material container 11 has a bottom through-hole 61 that penetrates the bottom 12c of the concave container 12 along the direction in which the liquid material container 11 and the microneedle 31 face each other. The bottom through-hole 61 is a circular hole configured with a cylindrical surface. The bottom through-hole 61 may be a polygonal hole configured with a polygonal cylindrical surface. The bottom 12c of the concave container 12 has a disk shape, and the bottom through hole 61 is located at the center of the bottom 12c. The bottom through-hole 61 may be located in a portion other than the center in the bottom 12c.

  The sealing part 13 has a supply passage 62 that penetrates the sealing part 13 along the direction in which the liquid material containing part 11 and the microneedle 31 face each other. The supply passage 62 is a position of the bottom through-hole 61 when viewed from the direction in which the concave container 12 and the sealing portion 13 overlap in a state where the concave container 12 and the sealing portion 13 are bonded. And the position of the supply passage 62 overlap each other. The supply passage 62 is a circular hole having a cylindrical surface. Similarly to the bottom through hole 61, the supply passage 62 may be a polygonal hole constituted by a polygonal cylindrical surface.

  The diameter of the container opening 62a which is an opening near the concave container 12 in the supply passage 62 is substantially equal to the diameter of the bottom through-hole 61, and the diameter of the container opening 62a is an opening close to the microneedle 31. It is larger than the diameter of the part 62b. The cylindrical surface constituting the supply passage 62 has a step surface 62c having a ring shape in the middle of the extension of the supply passage 62.

  The drawing member 63 has a cylindrical shape. The drawing member 63 may have a polygonal column shape. When the drawing member 63 has a polygonal column shape, each of the bottom through hole 61 and the supply passage 62 is preferably a polygonal hole.

  The drawing member 63 has a cylindrical shape, and has a small-diameter portion 63a having a relatively small diameter at one of the two ends, and a large-diameter having a relatively large diameter at the other portion. There is a portion 63b, and a step surface 63c having an annular shape is provided between the small diameter portion 63a and the large diameter portion 63b. The diameter of the small diameter portion 63a is substantially equal to the diameter of the needle opening 62b in the supply passage 62, and the diameter of the large diameter portion 63b is substantially equal to the diameter of the container opening 62a in the supply passage 62. The size and shape of the step surface 63 c of the drawing member 63 are substantially equal to the size and shape of the step surface 62 c of the supply passage 62.

  The microneedle unit 60 has an adhesive part 41, and the adhesive part 41 has an adhesive supply passage 64 that penetrates the adhesive part 41 along the direction in which the liquid material containing part 11 and the microneedle 31 face each other. The adhesive supply passage 64 is in the state where the sealing portion 13 and the adhesive portion 41 are bonded to each other in the adhesive portion 41, as viewed from the direction in which the sealing portion 13 and the adhesive portion 41 overlap. It is located in the part which the channel | path 64 overlaps. The adhesive supply passage 64 is a circular hole having a cylindrical surface. The adhesive supply passage 64 may be a polygonal hole formed of a polygonal cylindrical surface, like the supply passage 62.

  The diameter of the adhesive supply passage 64 is substantially equal to the diameter of the needle opening 62 b in the supply passage 62. The diameter of the adhesive supply passage 64 may be larger than the diameter of the needle opening 62b.

  In the microneedle 31, the protrusion forming portions 32 a 1 of the base body 32 face each other across the supply passage 62 and the facing surface 32 b of the base body 32. The microneedle 31 is formed of a material that dissolves in a liquid material among biocompatible materials.

  As shown in FIG. 9, in the microneedle unit 60, the diameter D <b> 1 of the large-diameter portion 63 b of the drawing member 63 and the diameter of the bottom through-hole 61 included in the concave container 12 are substantially equal. Thereby, when the drawing member 63 is positioned to block the supply passage, the inside of the concave container 12 is hardly exposed to the outside, so that the state of the liquid 51 located inside the concave container 12 is hardly changed.

  In the microneedle unit 60, the diameter D <b> 2 of the small diameter portion 63 a of the drawing member 63, the diameter of the needle opening 62 b in the sealing portion 13, and the diameter of the adhesive supply passage 64 of the adhesive portion 41 are substantially equal. Thereby, when the drawing member 63 closes the supply passage 62, the liquid material 51 located inside the accommodation space 11 a is hardly supplied to the facing surface 32 b of the microneedle 31.

  In the microneedle unit 60, when the sealing portion 13 has a step surface 62c in the middle of the supply passage 62 extending, and the drawing member 63 closes the supply passage 11b, the step surface 63c of the drawing member 63 is sealed. It overlaps with the step surface 62c of the stopper 13. That is, when the drawing member 63 closes the supply passage 11b, the supply passage 62 of the sealing portion 13 and the drawing member 63 are fitted. Therefore, the space between the surface of the supply passage 62 that contacts the drawing member 63 and the surface of the drawing member 63 that contacts the supply passage 62 are sealed. Therefore, the liquid material 51 accommodated in the liquid material accommodating portion 11 is stored in the liquid material through a gap between a surface of the supply passage 62 that contacts the drawing member 63 and a surface of the extraction member 63 that contacts the supply passage 62. It becomes difficult to leak outside the portion 11.

[Operation of microneedle unit]
The operation of the microneedle unit will be described with reference to FIGS. 9 and 10.
As shown in FIG. 9, when the microneedle unit 60 is used, the user first places the microneedle unit 60 on the target skin in a state where the protrusion forming surface 32 a of the microneedle 31 faces the target skin S. Put on S. At this time, the drawing member 63 closes the supply passage 62. And a user gives the force pressed toward the object with respect to the liquid substance accommodating part 11 of the microneedle unit 10. FIG. As a result, the protrusion 33 of the microneedle 31 pierces the target skin S, and the protrusion 33 forms a hole in the skin S.

  As shown in FIG. 10, the user picks the operation portion that is a portion protruding outward from the bottom portion 12 c of the concave container 12 in the drawing member 63, so that the liquid material storage portion 11 and the microneedle 31 face each other. A plug portion, which is a portion fitted in the supply passage 11b, is pulled out. Thereby, the position of the drawing member 63 with respect to the supply passage 62 of the sealing portion 13 is changed, so that the supply passage 62 is located between the storage space 11a of the liquid material storage portion 11 and the facing surface 32b of the microneedle 31. Connect. At this time, for example, the user pulls out the entire drawing member 63 to the outside of the liquid material storage unit 11. Therefore, the liquid material 51 located inside the accommodation space 11a is supplied to the facing surface 32b of the microneedle 31 through the supply passage 11b.

As described above, according to the microneedle unit of the second embodiment, the same effects as (1) to (5) described above can be obtained.
Note that the second embodiment described above can be implemented with appropriate modifications as follows.

  -The microneedle unit 60 does not need to have the adhesion part 41, and with such a structure, the microneedle 31 is attached to the sealing part 13 via an adhesive etc. like the microneedle unit 10 of 1st Embodiment. It only has to be adhered.

  The protrusion forming portion 32a1 of the microneedle 31 does not have to face the supply passage 62 with the facing surface 32b interposed therebetween, and a portion other than the protrusion forming portion 32a1 of the protrusion forming surface 32a of the microneedle 31 sandwiches the facing surface 32b. May be opposed to the supply passage 62.

  The microneedle 31 may have a through hole that penetrates the microneedle 31. In the configuration in which the microneedle 31 has a through-hole, the material for forming the microneedle 31 may be a substance to be dissolved that dissolves in the liquid or a material that does not dissolve in the liquid.

-The liquid material accommodating part 11 may be comprised from one member, for example, a bag body, and may form the accommodating space 11a inside.
The drawing member 63 and the supply passage 62 do not have to have a stepped surface, and each of the outer diameter of the drawing member 63 and the diameter of the supply passage 62 may be constant.

  The drawing member 63 and the supply passage 62 may have a configuration in which one has a fitting groove and the other has a fitting protrusion, as in the first embodiment and the modified example of the first embodiment.

  DESCRIPTION OF SYMBOLS 10,60 ... Microneedle unit, 11 ... Liquid substance accommodating part, 11a ... Accommodating space, 11b, 62 ... Supply passage, 12 ... Concave container, 12a ... Opening part, 12b ... Cylindrical body, 12c ... Bottom part, 12d ... Flange part , 13 ... Sealing part, 13a ... Fitting groove, 21, 63 ... Pull-out member, 21a ... Fitting protrusion, 31 ... Microneedle, 32 ... Base, 32a ... Projection forming surface, 32a1 ... Projection forming part, 32b ... Opposing Surface, 32c ... through hole, 33 ... projection, 41 ... adhesive part, 41a, 64 ... adhesive supply passage, 51 ... liquid, 61 ... bottom through hole, 62a ... container opening, 62b ... needle opening, 62c, 63c: Stepped surface, 63a: Small diameter portion, 63b: Large diameter portion, S: Skin.

Claims (6)

A liquid container containing a liquid material and having a supply passage for supplying the liquid material to the outside;
A microneedle having a base having a surface facing the supply passage, and having a protrusion on a surface opposite to the surface facing the supply passage among the surfaces of the base;
A plug for closing the supply passage;
A microneedle unit comprising: an operation unit that is located outside the liquid material housing unit and that is operated to move the plug unit so as to open at least a part of the supply passage. The microneedle unit according to claim 1, wherein the forming material of the microneedle is a substance to be dissolved that dissolves in the liquid. The microneedle unit according to claim 1 or 2, wherein the liquid includes a drug. The microneedle is
A through-hole penetrating the microneedle in a direction in which the liquid container and the microneedle face each other, wherein the microneedle is pierced by an object to be pierced by the microneedle and at least a part of the supply passage The microneedle unit according to any one of claims 1 to 3, wherein the microneedle unit includes the through-hole that connects the inside of the liquid material storage unit and the object when the object is opened. Of the surfaces of the base body, the surface facing the supply passage is an opposing surface,
Of the surfaces of the substrate, the surface on which the protrusion is located is the protrusion forming surface,
Of the projection forming surface, the portion where the projection is formed is a projection formation portion,
The microneedle unit according to any one of claims 1 to 4, wherein the protrusion forming portion and the supply passage are opposed to each other across the facing surface. The liquid material container is
A concave container containing the liquid,
A sealing portion having a plate shape that closes the opening of the concave container,
The sealing portion has the supply passage;
The adhesive part which spreads from the said opposing surface to the circumference | surroundings of the said opposing surface is further provided in the part which excludes the part in which the said supply channel | path is located in the surface which the said opposing part faces among the surfaces which the said sealing part has. The microneedle unit described in 1.

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