CN103120826A - Skin rolling needle - Google Patents
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- CN103120826A CN103120826A CN2012105455678A CN201210545567A CN103120826A CN 103120826 A CN103120826 A CN 103120826A CN 2012105455678 A CN2012105455678 A CN 2012105455678A CN 201210545567 A CN201210545567 A CN 201210545567A CN 103120826 A CN103120826 A CN 103120826A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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Abstract
The invention relates to a painless skin rolling needle used for fast cutaneous penetration or cosmetic products. A handle and a support of the fixing frame of the device are movably connected in a multidirectional sliding or multi-angle moving embedded mode, a rolling wheel seat is a hollow column cylinder, transdermal drug delivery, transdermal absorption and controlled-release system are improved, large numbers of micro pipelines can be formed through the rolling needle in a short time, medicines, the cosmetic products and the like are directly penetrated through epidermal cells, an epidermal wound is micro and is fast healed, and possibilities of bacterial infection are remarkably lowered. Skin hardening and cell shrinkage cannot be caused, an epidermal tissue also cannot become thin, and the skin rolling needle can be used for multiple times and further can be used for scalp massage to stimulate hairs to grow. The skin rolling needle is simple in preparation process, low in cost and side effect, obvious in effect, good in controllability, convenient to use, strong in practicality, capable of being directly used for daily life, suitable for large-scale production and commercial application in medical and cosmetic industries, and remarkable in benefit. In addition, a user can master the skin rolling needle through simple training.
Description
Technical field
The present invention relates to the technical fields such as medicine, beauty treatment, specifically relate to a kind of painless doser and structure and purposes that gives medicine, cosmetics etc. through skin, more particularly relate to a kind ofly reach that rapid transdermal absorbs or skin-painless needle roller and structure and the purposes of the good results such as slow release for transdermal administration or cosmetics.
Background technology
(1) research overview of micropin roller
1, general introduction
21 century, medical circle has faced a new problem at medical domain: how medicine correctly is transported to the position that need to treat, makes drug effect be maximized to get performance.The beauty treatment circle also faces same problem, more why be known as the high-tech nanotechnology, raw material is first-class and the product such as expensive beauty cream, cosmetic cream after use, effect does not have expectative so obvious, so medical circle is unprecedentedly active about the academic research such as percutaneous dosing, Transdermal absorption, slow release in recent years.The gene biological cosmetics can be to the Skin Cell reparation of reforming, but how these compositions is transported to skin needed position to cell metabolism generation effect, becomes a difficult problem of gene biological beauty treatment.
Horny layer is the firmest protective layer of skin surface; it is also can not the go directly major obstacle of skin bottom of nutrient in general cosmetics; medical circle is constantly sought new method, allows the nutrition of beauty treatment aging resistance can penetrate horny layer, directly enters each layer of skin generation effect.Many beauty apparatus are all to see through ultrasound wave intermediate frequency unidirectional current on the market, attempt to strengthen nutrient substance and pass through cuticular ability; How, effect is also not remarkable all the time, and this class technology of life-time service also can cause corse sweat pore.
Along with growth in the living standard, people are increasing to the demand that makes skin rejuvenation, health, reach cosmetic result in order to make skin, and at present method commonly used has: grind off epidermis, pickling, laser and remove epidermis etc.The common ground of these methods is: they are all the epidermal tissues of removing skin surface, the epidermal tissue that makes the dermal tissue manufacturing of epidermal tissue below make new advances, thus reach the effect that makes skin more healthy and smooth.But, use these methods also to have a lot of drawbacks to skin, the epidermis of human body is that the people resists the extraneous outermost layer barrier that infects, and is removed and new epidermal tissue not yet grows in complete process in old epidermal tissue, and skin very easily is subject to the infection of antibacterial and diseases induced; On the other hand, the convalescent period of these Therapeutic Method is long again, is generally the several months; And the skin of processing through these methods is understood attenuation, if overtreating possible scar also, so for most people, these Therapeutic Method could only use once at most.
2, micropin U.S.A definition and principle of moulding
By the development of science and technology, laser beautifying is becoming the first-selection treatment of female skin aging, mottle, wrinkle etc. symptom with brand-new attitude.And biological beauty and skin nursing are also just constantly being innovated with completely new concept and technology, and biological beauty is China's popular new technique instantly, particularly micropin beauty treatment, and one of popular new technique of first electing especially, its successful, simple to operate,
Now by the approval of vast beauty treatment mechanism, but pain is still the major issue that microneedle therapy faces, and the painless micropin of follow-up release can solve problems effectively, and it is wherein a kind of that micropin U.S.A moulds.
Micropin U.S.A moulds beauty treatment and comes from the U.S., claims again micropin mesoderm beauty curing (mesotherapy), or claims microneedle therapy (to be called for short: MTS).
It is the micropin that rolls on skin that micropin U.S.A moulds, use the micropin roller to stimulate human body skin, micropin can produce between the skin aspect and surpass 200 within very short time, 000 fine conveyance conduit, make the various active compositions such as Growth of Cells peptide gene active component and multi-nutrition element directly effectively infiltrate deep skin, the product assimilation effect is more than 4000 times of common spread product; Be equipped with wrinkle removal, speckle dispelling, whitening, the products such as striae gravidarum, scar eliminating of repairing, dispel, can efficiently repair rapidly, active cell, promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination cicatrix, mottle, smooth wrinkle, subtract light wrinkle, treatment cicatrix, anti-acne, anti-acne seal and striae gravidarum, skin whitening, subtract the light color speckle, improve eye wrinkle-removing, black eye, tighten up and promote the ideal effect such as skin of face tissue thereby reach.
the principle that micropin U.S.A moulds is a kind of therapy of improving looks for the skin mesoderm, this therapy is skin care activity composition or nutritional labeling to be input to mesoderm by certain special installation (that is: instrument is moulded by U.S.A) play a role, and this U.S.A to mould instrument be exactly micropin roller (B.N.M meso Roller or Meso Roller, sometimes also be called for short: micropin) or U.S.A mould rifle (MesoGun), different equipment has different action principles: the micropin roller is to utilize that on roller, many little pins (small syringe needle) penetrate horny layer, chafe, micropin can be made and surpass millions of ultra micro tubules within very short time, be equipped with wrinkle removal, whitening, repair, the striae gravidarum of dispelling, the specially good effect products such as scar eliminating, make active component effectively infiltrate skin and the importing of aidant component, subtract light wrinkle thereby reach, treatment cicatrix and striae gravidarum, the skin whitening, subtract the light color speckle, improve eye wrinkle-removing and black eye, tighten up and promote the ideal effects such as skin of face tissue, simultaneously micropin stimulates skin corium, and percutaneous self-healing ability promotes the ossein hypertrophy, can the match in excellence or beauty plastic operation of laser and filled type of the thickness hypertrophy that can make skin epidermis approximately 8%, its effect.And the microsyringe that rifle is automatization is moulded by U.S.A, directly composition is expelled to subcutaneous.These two kinds of equipment can be selected according to the needs of self, and the micropin roller is safe, and is easy to use, be widely used, and U.S.A mould rifle and mainly some superiority arranged aspect partial-depth wrinkle and local weight reducing fat melting tackling.
Micropin U.S.A mould be utilize a kind of deep layer be used for skin is carried out aesthetic nursing, compared with superficiality nursing in the past, this treatment can reach effect more thoroughly, but also can guarantee can not cause extra infringement to skin, so be a kind of desirable beauty treatment means.
Micropin U.S.A moulds and can open towards the passage of skin basal layer moment, somatomedin is transported to the skin bottom endlessly: can activate self cell regeneration, strengthen self synthetic and Secretion, endogenous replenishing collagen and elastic fibers, remove interior free yl, reduce biological oxidation and aging; Can directly act on basal layer melanin, check melanin generates, and spot fading is accelerated metabolite and transported, and removes the free radical that causes human senility, thus delaying skin aging, and that skin and muscles are fair is smooth in order, fine and smooth as silk; Wrinkle removal simultaneously skin becomes delicate smooth and compacts beautifully, strongly promotes division and the growth of Skin Cell; Irritate the synthetic and secretion of hyaluronic acid, collagen protein and glycoprotein etc., make the wrinkle of skin Lock-out, skin recovers gloss and elasticity, is fit to the dark person of local wrinkle.In the time of the micropin chafe, can also stimulate the hypertrophy of skin corium collagen and fibroblast, not only small wound healing is rapid, and preventing from scar.
Micropin U.S.A moulds and can effectively improve the face skin problems such as sunburn, chloasma, freckle, plumbous mercurialism, facial pigmentation skewness, the colour of skin are dark and gloomy, the coarse tarnish of skin; For acne pothole skin, the contained biology acne pothole skin-active composition of dispelling directly acts on the fibrocyte of deep skin fracture, promotes collagen protein synthesis, regenerate fibrous tissue, thereby arrive the reconstruction of deep layer reticular fiber structure, calm down the acne pothole, reappear smooth fine and smooth skin.
3, the characteristic of micropin beauty treatment
Effect and the characteristics of micropin beauty treatment:
1. utilize the normal healing ability of wound, can not make the skin hardening or cause that Skin Cell shrinks.
2. micropin can be made a large amount of microtubules, makes active component effectively infiltrate skin (only need to use five minutes, just can produce over 200,000 micropores).
3. side effect is extremely low.
4. use after microneedle theraphy nursing simple and easy, can carry out general outdoor activities, comprise and getting sun.
Advantage is moulded by micropin U.S.A:
Naturality: do not affect histrionic muscles and face nerve, after reduce wrinkle, the expression natural shape is harmonious.
Safety: with the human body homology, without obviously rejection and side effect, leave no trace after treatment, cicatrix, safe and reliable.
Persistency: promote human body cell continuous release collagen protein, elastin laminin, curative effect is permanent.
Simplicity: with doing with walking, noinvasive is painless, does not affect work and life, also referred to as " lunch break erugation ".
High efficiency: dispel true property wrinkle and reach more than 95%, reverse aging, young 5 ~ 10 years old.
The problem that the micropin roller solves:
1. subtract light wrinkle, bring out the ossein hypertrophy, treatment areolar tissue, skin thickness problem, treatment cicatrix and striae gravidarum;
2. skin whitening subtracts the light color speckle, improves eye wrinkle-removing, black eye, stimulates the ossein hypertrophy, tightens up and promote the skin of face tissue;
3. administer alopecia, care and household etc. and effectively carry nutrient.
Now a lot of cosmetics all have in various degree damage to skin, be undoubtedly a kind of injury concerning using such personage that likes to be beautiful, so they are more careful when selecting cosmetics, and the harm that micropin U.S.A moulds is almost non-existent, is substantially without a kind of more safe and reliable beauty method that damages to skin.
It is to mould instrument by U.S.A the required nutrient of skin is imported to reach cosmetic result after making skin fully absorb in the skin that needs to change that micropin U.S.A moulds, it is different from other beauty method, be need not operate on, need not take medicine, accurate effective beauty method, it is a kind of point-to-point beauty method: the integrity that does not destroy skin texture, set up a large amount of skin microtubules, the transport substrate cosmetics; Progressively remove deep skin toxin and refuse; The chafe self-healing ability promotes skin metabolism, keeps skin elasticity and handsome U.S.; Active cell, reparation damaged tissues are participated in cellular metabolism directly, reach wrinkle removing, lifting, whitening, antidotal effect; Utilize the normal healing ability of wound, induce nutrition and the collagen growth of skin self; Safe and reliable having no side effect.
The harm of moulding of micropin U.S.A is almost non-existent thus, and, instant effect short by the time of its beauty treatment, without cicatrix all is suitable for the crowd of various skin problem.
The rise that micropin U.S.A moulds has solved the century difficult problem on the world of medicine, beauty treatment circle.Use B.N.M meso Roller chafe, make a large amount of microtubules, make active component effectively infiltrate skin.Trickle rolling acupuncture can also stimulate the hypertrophy of skin corium collagen protein and fibroblast simultaneously.This kind Wicresoft is that use is also less than 30G fine needle " micropin " carry out the aculea action, not only " Wicresoft hinders " healing is rapid, and preventing from scar.In other words, directly with Growth of Cells peptide gene active component and multi-nutrition element etc., give the skin cell rapid osmotic of different depth via very tiny pin hole.These tiny Wicresofts can't cause the excessive wound of skin and burden, in reparation period, can also activating cell, and promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination pox scar color element; + 6 also can allow Skin Cell see through microtubule directly absorbs the gene activity composition that skin needs, and assimilation effect approaches absolutely, therefore can give different formulas for demands of individuals, and new skin is lived again, and thoroughly improves skin quality.
4, micropin roller
(1) textual investigation
The micropin roller is that instrument used is moulded by micropin U.S.A.Micropin, the needle set name, the appearance of micropin one word can be found at Huangdi's Internal Classics, and it refers to the fine fine little needle sets such as acupuncture needle." the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " in Huangdi's Internal Classics: " wanting to transfer its vim and vigour with logical its passages through which vital energy circulates of micropin ... ", nowadays, micropin just is widely used in beauty treatment.
The justice of micropin has two:
1. small pin, little pin." Plain Questions treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it is controlled should micropin." the Wang Bingci notes: " little, also tiny.Tiny pin, pulse-taking decline and contain also." " the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint ": " wanting of little pin easily oldly and difficult enters." " class is through 19 volume acupuncture classes one ": " little pin, the i.e. meaning of micropin above.”
2. nine kinds of needles." Plain Questions treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it is controlled should micropin.Therefore the nine kinds of needles person also comes from south." " Plain Questions knowledge ": " [nine kinds of needles], high cloud: ' " Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles opinion " Yellow Emperor, a legendary ruler want with logical its passages through which vital energy circulates of micropin.Micropin, little pin also.The little pin of qi uncle opinion and and in nine kinds of needles, therefore the person that says the nine kinds of needles also comes from south.' letter press: " the nine kinds of needles twelve source acupoint ": ' Supreme Being asks useless stone needle, wants with logical its passages through which vital energy circulates of micropin.And qi uncle answers to start from one finally nine.' micropin be namely nine kinds of needles, for stone needle, outside non-nine kinds of needles, micropin is arranged.Will cloud: ' micropin person.Its cutting edge of a knife or a sword is fine.The pin of shallow puncture also.' fear non-ly be.”
The micropin roller is medicine in France expert Horst doctor's invention the earliest, adopts Switzerland's high-quality medical treatment rustless steel, continues to use the casting method of German craftsman invention in 1896, forms in the subzero 60 supercool freeze techniques manufacturings of spending Celsius.So, the based on very high purity of micropin, very hard.
Present a micropin roller is based on the Anti-slip handle of bionic design, the pure moulding of streamlined fashion, and run-bake-needle fault not, needle point is round and smooth sharp, is the latest generation micropin roller of present leading industry.
(2) basic structure and specification
On the micropin roller, with a lot of diameter micropins the same with spacing, different needle roller spacing and the diameter of its micropin is understood some difference, be to select the micropin specification that is fit to according to skin conditions, and be generally that pin length is the micropin of 0.3 ~ 1.25mm.Long micropin is more deep to the stimulation of skin, and relatively high to treatment personnel specification requirement, the micropin that treatment is used not is that the longer the better yet; If be not suitable for patient's skin thickness, that effect can only be reciprocal, because it is to sting the expelling pathogenic factors from the exterior skin by micropin that the principle that works is moulded by micropin U.S.A, import to be fit to again the essence of relevant skin problem or medicine etc., allow like this within essence or medicine etc. directly are penetrated into epidermis, improve and repair cortical tissue and cell.
So the treatment of the saturating property of such thorn need to allow the doctors and nurses of specialty operate in medical cosmetology mechanism, people's one pin, strict sterilization is not reused, the safety of guarantee treatment.
Micropin specification (mm i.e. millimeter, is the length of pointer, is not the width of roller):
1. 0.25mm: generally be used for going red blood streak, cell more living;
2. 0.5mm: generally be used for wrinkle removal, whitening, speckle dispelling, receipts fine, soft fur hole;
3. 1.0mm: generally be used for recessed scar, pox hole, cicatrix reparation;
4. 1.5mm: generally be used for going striae gravidarum.
(3) related products
The product that report is arranged at present, for example Mesomed micropin rod is to make with plastic cement, volume is light and handy, the above's about 200 very tiny medical titanium syringe needles that distribute.
A kind of commercially available micropin roller product section details is as follows:
Weight: 55 grams (comprising packing)
Package size: 16cm * 3.5cm * 5.5cm
Color: white orange or transparent orange
Micropin material: medical use rustless steel (silver)
Micropin is arranged: yi word pattern is in line
Ai disappears: EQ Gas, the Gamma Ai ray that disappears, ethanol, the UHT high temperature Ai that disappears
Namely abandon: be (Ai unless again disappear)
Pin is long to be selected: 0.2mm/0.25mm/0.3mm/0.5mm/0.75mm/1.0mm/1.5mm/2.0mm/2.5mm/ 3.0mm
OEM/ODM selects: can
Environmental conservation: identify the greening material
Specification: ISO 11137, CE, FDA
On the micropin roller, micropin quantity is 540, and pain reduces by half than common micropin; The kermesinus roller, bright pearl white handle.
The solid roller design of this product guarantees to use safety.
The solid roller design of Britain's micropin is derived from the requirement of FDA and CE blueprint, and has adopted seamless technology to produce and guaranteed that antibacterial can not grow at roller after sterilization, but more stops to appoint the disaster of bacterial invasion.Some low-cost hollow roller micropins of being convenient to produce occurred on the market recently, hollow roller can lower the trouble of much installing undoubtedly, but this design but has large health test problems absolutely.For example in nursing the course for the treatment of, coat because of carelessness the fine blood streak remaining on facial skin care item or micropin and also can enter through the joint close on hollow roller the middle part of roller.Ai does perfectly not if disappear, and the micropin roller that this FDA of not meeting or CE require is definitely might make skin be subject to the crisis of bacterial invasion and leave behind permanent injury.
The whole handle of micropin requires through meeting ergonomic designs, and this design can reduce the strain on finger effectively and the grip that increases between finger tip and handle has avoided unclamping because of carelessness the injury that handle can be made (for example the barefoot hands is slippery absent-mindedly).The material that micropin uses can bear high temperature, heat-resisting not modification.
Have a kind of Product Report of painless aculea rolling instrument to claim: the life-span of high-quality micropin roller and effect are that the grinding state by the material of micropin itself and needle point determines.192 micropins of the painless micropin roller of this product are to be made by Korea S's high density medical stainless steel, in conjunction with international advanced pin technology processed, draw point is hard, and atomic thin, so can not cause client's pain when thrusting skin, the common needle roller of the above painless needle roller contrast same specification of 0.5mm could make client's pain reduce more than 50% 0.25mm it is 100% painless that the needle roller of length can reach!
Also have a kind of Product Report to claim: the structure of skin needle roller is composed as follows: needle body adopts 0Cr19Ni9 or other austenitic stainless steel wires select in GB/T4240 " stainless steel silk ", through sharpening, injection moulding, inlay, the operation manufacturings such as assembling, heat-sealing form.It is 0.2mm, 0.3mm, 0.5mm, 1.0mm, 1.5mm, 2.0mm that this product exposes the outer needle body length of surveying of roller sheet; The needle body diameter is 0.16mm, 0.18mm, 0.20mm, 0.22mm, 0.25mm, 0.30mm; The technical parameter of this product is: needle body hardness 〉=460HV, the numerical value of 0.2kg surface roughness Ra are not more than 0.5 μ m.The design of needle roller spreads all over intensive, and pin and pin only have 0.3mm apart, can reach the optimal healing effect to wound.
(4) relevant patent application
Patent of invention " a kind of miniature needle roller " (application number: 200810089036 is arranged, the applying date: 2008-04-16) claim: a kind of miniature needle roller, comprise a plurality of fine needle substrates 10, cylinder substrate 20 and pair of discs 30, described fine needle substrate 10 is comprised of a plurality of microneedle 11 of configuration at a certain distance, and there is jut 12 lower end, both sides of fine needle substrate 10; The both sides of described cylinder substrate 20 are provided with patchhole 21, and the jut 12 of fine needle substrate 10 lower ends, both sides can directly be inserted in this patchhole 21; Described disk 30 comprises the fixedly insertion section 31 of annular.Described whole cylinder substrate 20 and fine needle substrate 10 in conjunction with after, both sides in conjunction with protuberance 13 form an integral body in conjunction with fixed part 22, be inserted in the fixedly insertion section 31 of above-mentioned disk 30, when preventing from rotating, fine needle substrate 10 and cylinder substrate 20 break away from.After adopting the present invention, its simple and convenient assembly saves time and laborsaving, reaches the effect that fraction defective is minimum, productivity ratio is the highest.In addition, the effect that in the time of can also reaching pre-anti-rotation, fine needle substrate and cylinder substrate break away from mutually.
Utility model patent " skin needle roller " (application number: 200720035626.1 is arranged, the applying date: 2007.03.23) claim: a kind of skin needle roller, it comprises roller mount, be arranged at a plurality of needle bodies on the external peripheral surface of described roller mount, the diameter of described each needle body is 0.07 ~ 0.35 millimeter, and the length of exposing at the roller mount Outboard Sections of described each needle body is 0.1 ~ 3 millimeter.Driving needle body by roller mount rolls on the skin of human body, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thereby chafe, promotion ossein hypertrophy, for the natural reaction to the epidermis tissue injury, dermal tissue can be made the epidermal tissue that makes new advances, thereby reaches the effect of health rejuvenation skin.Use this skin needle roller, need not to remove epidermal tissue and can reach the effect that makes epidermal tissue's regeneration, and because the epidermis wound is small, healing stage is very fast, the probability that is subject to the antibacterial infection also is lowered; In addition, it can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, and application risk goes the method for epidermis far below tradition.
(5) up-to-date basic technology progress
" Science and Technology Daily " December in 2011 reported on the 23rd: the engineer develops painless silk micropin, can accurately control drug release.Organize 22 (Beijing time) of net December, the bioengineer of engineering college of U.S. Tufts University to develop a kind of painless silk microneedle device according to U.S.'s physicist, can with sustained release in long-time, need not the unnecessary medicine of cold preservation.This micropin has biocompatibility and biological degradability concurrently, can make under normal temperature and pressure, can load the biochemical drug that easily is damaged and keep its activity.Relevant paper is published on " advanced function material " website.
Demonstrator Trials shows, the New type silk micropin can be sent macromole, catalator medicine, horseradish peroxidase with controllable speed, also keeps simultaneously the biological activity of medicine; The silk micropin that loads tetracycline can also suppress the growth of staphylococcus aureus, shows this micropin in delivering therapeutic agents, also has the potential value of prevention local infection.
Although some medicine can directly be swallowed, some can't bear the gastrointestinal digest and decompose.Hypodermic mode is more painful, can not slowly discharge medicine.Only have small-molecule drug seldom to enter in body with the mode that sticks.Silk micropin 1 micron size only can penetrate upper strata skin and can not touch nerve, is a kind of new painless type mechanisms for drug release.But have at present a lot of difficult problems to hinder the development of this technology, as the vulnerability of biological product make medicine in manufacture process loss of activity, can not accurately control drug release or put infection that too much, the small skin penetration of medicine brings etc.
For these problems, research worker has been developed new fabrication schedule, and process comprises pressure, temperature and water treatment etc.They are formed from aluminium the micropin master mold, line up 500 microns high, and needle type radius is less than the array of 10 microns; (be called for short: PDMS) be cast in and form die on master mold with resilient dimethione; Again the silk protein solution that medicine is housed is injected die.After the silk drying, then the silk micropin that comprises medicine is taken off further processing.Post processing comprises with steam limbers up it, then passes through the various processing of temperature, machinery and electronics, makes it have corresponding diffusibility and drug releasing rate.
Research worker represents, regulates the post-treatment condition of fibroin, as changing drying time, is mainly the secondary structure of controlling it, can accurately control drug releasing rate.Through discharging the dynamic model test, drug releasing rate can reduce by 5.6 times, and this has solved a drug release difficult problem for a long time, can also be used in other biological storage aspect.
Paper co-author, Ta Fusi biomedical engineering chairman David Kapp orchid also point out, this micropin is very flexible, can enlarge or dwindle, transport or store to need not cold preservation, and it is easy just as plaster or binder that management is got up.
The non-fresh thing of microneedle therapy.Ancestor " the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " just has cloud: " wanting to transfer its vim and vigour with logical its passages through which vital energy circulates of micropin ... ".Although the size of those micropins cannot compare really with present pinpoint array less than 10 microns radiuses, the principle of from outward appearance to inner essence curing the sickness to save the patient, broadly similar.As for the main innovate point of Tufts University, show that in fact they select silk and organosilicon to make base material, utilize material behavior to realize slow release, controlled release.Heal to become in maturation when microneedle therapy, that try the water can not be the patient of hanging down, but the woman that large quantities of wish is held for happy own person.
(2) research overview of needle roller
1, general introduction
The product somewhat similar with micropin has the device that contains needle roller, is a kind of be used to the particularly machinery of the Suzhou embroidery skill of handling needles of embroidering.
2, needle roller
Needle roller (needle roller) refers to that the length-to-diameter rate is greater than 2.5 small diameter cylinders roller, belonging to the rolling bearing (three grades of subjects) in the mechanical machine components of one-level subject (secondary subject) of application branch of learning, is a kind of in the sewing of one of Suzhou embroidery skill of handling needles bar.Palpus, the eyebrow of the suitable embroidered beast of this needle roller, personage's hair, the pleat stricture of vagina of clothes and thin narrow pattern line kind etc.The two tight Jing'an of line become striped, and the lines turnover is more flexible.Embroider straight line, curve all more appropriate.
The embroidery step: fall after rising before the grain pattern lines, the pin pin is tightly secret, and lines length is same, and approximately a city divides the left and right.The turning point can be slightly short, so that turnover.After embroidering the first pin, second pin that should fall at the first pin 1/2nd places makes under the last pin of needle tracking plant.The 3rd pin drops on 1/2nd places of the second pin, tightly presses the end of the first needlework bar, by that analogy.
Needle bearing (needle roller bearing): referring to that rolling element is the radial bearing of needle roller, is the roller bearing with cylindrical roller, and its diameter relatively, roller are not only carefully but also long.This roller is called needle roller.Although have less cross section, bearing still has higher load-bearing ability, therefore, is specially adapted to the restricted occasion of radial space.
The needle roller contoured surface shrinks a little at the proximal end face place.The result of needle roller and Race Line Contact correction can avoid producing damaging edge stress.The supporting rollern needle bearing is the heavy wall outer ring, quenches through the high nitrogen of high temperature, and the roller of high-accuracy sorting utilizes the wire contact by the lip-guided of high rigidity outer ring, and roller can directly easily rotate on raceway, and can bear huge load.Be to remove stress, the cambered surface design is adopted in the outer ring of support roller, all size models such as curving roll is with single, double sealing ring, is not with sealing ring, band sealing ring.Band sealing ring storage grease space is large, provide the lithium saponify permanence lubricated, and extends lubricated interval.The sealing ring material is band skeleton acrylonitrile-butadiene rubber or ST12, and its operating temperature scope is-30 ℃ to+100 ℃ or-30 ℃ to+180 ℃.The curving roll of closely packed formula can bear heavier extremely strong load and high performance operation.The RSTO outer ring is without rib, without the inner ring supporting rollern.
The characteristics of needle bearing and purposes:
Needle bearing is equipped with thin and long roller, and (roller length is 3 ~ 10 times of diameter, diameter generally is not more than 5mm), so radial structure is compact, when its internal diameter size is identical with the other types bearing with load-carrying ability, external diameter is minimum, is specially adapted to the radially restricted supporting result of installation dimension.Different according to use occasion, can select bearing or needle roller and retainer assembly without inner ring, the journal surface that match with bearing this moment and shell aperture surface are directly as the inside and outside rolling surface of bearing, for guaranteeing load-carrying ability and behavior in service and having the lasso bearing identical, the hardness of axle or shell aperture raceway face, machining accuracy and surface quality should be similar with the raceway of bearing ring.This kind bearing only can bear radial load.
The type of needle bearing:
The bearing that can be used for common engineering, as: open type drawn cup needle roller bearing, closed drawn cup needle roller bearing, tool inner ring needle bearing and do not have inner ring needle bearing/without inner ring without the retainer needle bearing, retainer is arranged and fills needle bearing without retainer.
Although above-mentioned needle roller device is different from technical field of the present invention, the place that can be worth reference and reference is arranged still also on the product manufacturing technology with beauty treatment skin needle roller of the present invention.
Therefore, seek novel, Transdermal absorption better effects if, use that the skin-painless needle roller is still imperative more easily.
By literature search etc., up to the present, still find no the skin-painless needle roller product of renewal and the report of the aspects such as structure and purposes thereof.
Summary of the invention
The technical problem that will solve required for the present invention is to disclose a kind of a kind of skin-painless needle roller and structure and purposes that reaches the good results such as Transdermal absorption, slow release for transdermal administration or cosmetics, namely this device has the new roles such as Quick medicine, easy to use, infection chance is few, can be used in the technical fields such as medicine, beauty treatment, the defects that exists to overcome prior art.
That is to say, the present invention is directed to the deficiencies in the prior art, by practical studies and theory studies such as zoopery and clinical trials, one of purpose is intended to provide a kind of new doser, and a kind of safer, more convenient, skin-painless needle roller of more easily controlling namely is provided; Two of purpose of the present invention is to provide a kind of purposes of new micropin tourelle.
Skin needle roller of the present invention (also claims: skin needle roller device, micropin roller devices sometimes, skin micropin roller devices, micropin tourelle, skin micropin tourelle, needle roller device etc.) refer in the technical fields such as medicine, beauty treatment, a kind ofly be directly used in product quick, painless Transdermal absorption; Preferably be directly used in the product of beauty industry, i.e. the U.S. molding product of a kind of new micropin.
(1) technical conceive
Explore and improve existing micropin technology and supporting skin needle roller is a urgent task of Chinese medical, beauty industry safety, Quick medicine or cosmetics, particularly to study and improve and fast medicine, cosmetics correctly to be transported to the subcutaneous location that need to treat, effect is maximized, be the forward position of the academic researchs such as percutaneous dosing, Transdermal absorption, slow release, can solve a difficult problem of biological beauty.
Horny layer is the firmest protective layer of skin surface; it is also can not the go directly major obstacle of skin bottom of effective ingredient in general medicine, cosmetics etc.; medical circle, beauty culture are all constantly being sought new method; allow relevant effective ingredient can penetrate horny layer, directly enter each layer of skin generation effect.
In actual use, the inventor finds existing skin-painless needle roller, general skin skin needle roller for example, when particularly facial skin uses in use, when processing skin, higher to operation requirements: the one, when dragging back and forth the skin skin needle roller, skin creases easily, if excessive velocities causes hemorrhage or pain, need to take moderate speed; The 2nd, need skin surface to be processed possible uneven, particularly in face, the angle and direction that often needs conversion at any time to drag in the process that drags increases the uncontrollability that operates, and has improved the requirement of operation; The 3rd, the needle body length of same skin skin needle roller is fixed, different parts or different demand to same client often need to use two or more skin skin needle rollers, increase customer cost, use in turn different skin skin needle rollers, also increased the chance that may cause infection; The 4th, need to first process skin, after forming a large amount of trickle ducts, could administration or cosmetics etc., be difficult to carry out simultaneously, operate untimely or other are improper, increased the chance that may cause infection.
Therefore, for reducing infection chance, improving safety, increase control convenient, convenient more people use, and particularly are convenient to client oneself and directly use this skin needle roller, according to this idea and thinking, the inventor has consulted a large amount of data, compare existing various product, experimentation and analysis and theory study by repeatedly successfully obtain result of study and the application product of expecting.
The present invention be mainly for utility model patent " skin needle roller " (application number: 200720035626.1, the applying date: 2007.03.23) carry out improvedly, and its purposes is expanded to a plurality of technical fields such as medicine, beauty treatment.
The woman's beauty treatment of improving looks particularly is the focus that the whole world all is concerned about, rapid transdermal administration, Transdermal absorption, slow release etc. are also the focuses that pharmaceuticals industry generally is concerned about.Heal to become in maturation when microneedle therapy, the woman that will have more large quantities of wishs to hold for happy own person.If spread uses skin needle roller of the present invention, this technology will have significant social benefit, economic benefit.
(2) skin needle roller and uses thereof
The present invention has carried out many-sided test and study to skin needle roller at beautifying skin, rapid transdermal administration, Transdermal absorption, slow release etc. and has explored.
Technical scheme of the present invention is as follows:
A kind of skin needle roller, it comprises fixed mount and needle roller two parts:
Described fixed mount comprises handle 1, sees Fig. 1 by junction 9 and the support 6 of handle 1 flexible connection, the roller bearing 4(that is connected with support 6);
But the preferred embedded mode that adopts multi-faceted slip or multi-angle to move of described handle 1 carries out activeness with support 6 and is connected, and namely described handle 1 and the junction 9 of support 6 are that embedded mode that the multi-faceted slip of employing or multi-angle move carries out activeness and is connected;
Described handle (1) is that the embedded mode that adopts multi-faceted slip or multi-angle to move carries out the connection that activeness is connected with the junction (9) of support (6);
Described needle roller comprises roller mount 2, be arranged at a plurality of needle bodies 3 on the external peripheral surface of roller mount 2, offer at the axial line place of roller mount 2 roller bearing hole 7; By roller bearing 4 with roller mount 2 pivotal mounting on support 6, be convenient to control roller mount 2 (see figure 2) of rolling by the mode that pushes away or draw on human body skin;
Described roller mount 2 is hollow cylinders, preferred cylinder; Needle body 3 is hollow needle body; And each row needle body 3 is directly fixed on roller mount 2, distributes by multiple row on the external peripheral surface of roller mount 2, and preferably by 3 ~ 9 column distributions, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2; The material that roller mount 2 is used has elasticity, and when dragging apparatus of the present invention, under the pressure that drags, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3;
The diameter of described each needle body 3 is 0.07 ~ 0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1 ~ 3 millimeter; Drive needle body by roller mount 2 and roll on the skin of human body, needle body can pierce through the epidermal tissue of skin, and it is caused small wound, then reaches dermal tissue.
The present invention is mainly used in the percutaneous drug delivery at the positions such as the health, face of human body or cosmetics etc., can be used for the direct administration of human buttock or skin of abdomen to reach the effect of quick weight-lossing, is preferred for the percutaneous drug delivery of human face or cosmetics etc.; And except the skin of health and face, also this skin needle roller can be applied to massage skin of head, with blood circulation promoting, stimulate the growth of hair.
Existing skin needle roller (application number: 200720035626.1, the applying date: 2007.03.23) comprise fixed mount and needle roller two parts, described fixed mount comprises handle 1, roller bearing 4, support 6; Described needle roller comprises roller mount 2, needle body 3, roller bearing hole 7; Each modular construction and basic annexation are as follows:
Described handle 1 is fixedly connected with support 6, and support 6 is connected with roller bearing 4; Described roller mount 2 comprises a plurality of wheel sheets 5 in the form of annular discs, described a plurality of sheet 5 of taking turns is arranged in order and connects in the end, described a plurality of needle body 3 distributes by multiple row on the external peripheral surface of roller mount 2, and each row needle body 3 is fixedly clamped respectively between adjacent wheel sheet 5; Offer roller bearing hole 7 at the axial line place of described roller mount 2, by roller bearing 4 with roller mount 2 pivotal mounting on support 6, be convenient to control roller mount 2 by the mode that pushes away or draw and roll on human body skin;
The diameter of described each needle body 3 is 0.07 ~ 0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1 ~ 3 millimeter;
Preferred mode is: described a plurality of needle bodies 3 are pressed 3 ~ 9 column distributions usually on roller mount 2, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2.
The present invention improves following two aspects:
The one, improved the connected mode (see figure 1) of handle 1 and support 6, namely handle 1 adopts revocable movable connection methods with the junction 9 of support 6, but namely handle 1 adopts multi-faceted slip or multi-angle to move embedded mode to carry out activeness with support 6 and be connected; This improvement has solved and has been difficult to the problem that random conversion drags angle and direction, has increased handlingly, is easier to use;
The 2nd, improve roller mount 2 and needle body 3(and see Fig. 2), described roller mount 2 is hollow cylinders, no longer comprises a plurality of wheel sheets 5 in the form of annular discs, preferred cylinder; Needle body 3 by solid change into hollow; And each row needle body 3 is fixedly clamped respectively and changes each row needle body 3 into be directly fixed on roller mount 2 between adjacent wheel sheet 5; The material that roller mount 2 is used has elasticity, and when dragging apparatus of the present invention, under the pressure that drags, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3.Adopt disposable occupation mode, when this improvement just can solve processing skin, the problem of administration simultaneously or cosmetics, reduced operation sequence and infection chance, is more convenient for using, and is easy to promote.
Improve from above population structure and introduce with further elaborating of technical scheme and can find out, the micropin tourelle is a kind of novel device that is used for the purposes such as beauty treatment, administration, can be used in client or patient's the aspect such as beautifying skin, percutaneous drug delivery, not only simple in structure, easy operation, usage charges are low, and firmly symmetrical stable, but the dragging speed self regulation has reduced the chance that infects, use safelyr, having improved can be handling.
(3) technology speciality
The present invention provides a kind of new beautifying skin, the apparatus of percutaneous drug delivery for medical treatment, beauty industry, thereby improve and improve medicine, cosmetics correctly being transported to the systems such as the subcutaneous location that need to treat, particularly percutaneous dosing, Transdermal absorption, slow release.The present invention is safe and effective, and practicality is stronger, and its preparation technology is simple, and is inexpensive, simple to operate, convenient and swift, can grasp through simple training, can be directly used in daily life.
Advantage of the present invention is: the needle roller therapy utilizes the normal healing ability of skin to complete, and can not make the skin hardening or cause the contraction of Skin Cell, and needle roller can be made a large amount of microtubules, is beneficial to directly infiltrate medicine, nutritional solution etc. subcutaneous.Use the rear nursing of needle roller treatment simple and easy, can carry out general outdoor activities, comprise and getting sun.In addition, this skin needle roller can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, because the epidermis wound is small, healing stage is very fast, the probability that is subject to the antibacterial infection also is lowered, application risk is far below the method for in the past traditional removal epidermis, and except the skin of health and face, also this skin needle roller can be applied to massage skin of head, with blood circulation promoting, stimulate the growth of hair.
Driving needle body by roller mount rolls on the skin of human body, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thereby chafe, promotion ossein hypertrophy, for the natural reaction to the epidermis tissue injury, dermal tissue can be made the epidermal tissue that makes new advances, thereby reaches the effect of health rejuvenation skin.Use this skin needle roller, need not to remove epidermal tissue and can reach the effect that makes epidermal tissue's regeneration, and because the epidermis wound is small, healing stage is very fast, the probability that is subject to the antibacterial infection also is lowered; In addition, it can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, application risk goes the method for epidermis far below tradition, this skin needle roller can effectively promote the penetration of medicine, cosmetics of skin etc., the effect that medicine, cosmetics etc. pass through skin epidermis and skin corium cell is especially remarkable, is the scientific and technological new technique of the carrying methods such as medicine, cosmetics.Moreover skin needle roller stimulates the wound self-healing ability of skin corium, thereby chafe promotes the ossein hypertrophy, and for the natural reaction to the epidermis tissue injury, dermal tissue can be made the epidermal tissue that makes new advances, and the thickness hypertrophy that can make skin epidermis is percentage eight approximately.And the side effect of skin needle roller technology is extremely low, and is safe and reliable.
The present invention studies the apparatus of Transdermal absorption targetedly, and it uses safety, has brought into play to greatest extent effect; Product property is stable, can be suitable for suitability for industrialized production; The successful of Transdermal absorption medicine, cosmetics etc., and the scope of application is wide, therefore is easy to apply, and can have a tremendous social and economic benefits in the short period of time.
The present invention provides a kind of new apparatus source for Transdermal absorption, thus to existing Transdermal absorption product systems particularly the Drug Percutaneous Absorption product carried out improvement, improved, thereby the application of having expanded existing Transdermal absorption product.
The present invention is safe and effective, and practicality is stronger, and is inexpensive, convenient and swift, and easy, the easy operation of its preparation technology is easy to use, evident in efficacy, can be used for all kinds of Transdermal absorption.
The present invention studies Transdermal absorption targetedly, has found a kind of new skin needle roller, and the micropin tourelle has been expanded new purposes, also for Transdermal absorption provides a kind of new rule of origin, has made beyond thought achievement; Simultaneously, the present invention uses safety, and is handling good, the Transdermal absorption successful, brought into play to greatest extent the effect of product, the large-scale production and the business that are more suitable for the industry such as medicine, beauty treatment and industry are used, and can have a tremendous social and economic benefits in the short period of time.
In a word, active adaption of the present invention the job demand of modern beauty, medicine and scientific research field and the needs of human nature service, the present invention has important value for the research and development Transdermal absorption provides new apparatus source to improving and improving existing Transdermal absorption system.
Description of drawings
Accompanying drawing 1 is the schematic diagram of fixed mount of the present invention;
Accompanying drawing 2 is the schematic diagram of needle roller of the present invention;
Accompanying drawing 3 is dynamics and depth relationship curve;
Accompanying drawing 4, be the experiment effect figure (Franz diffusion cell method) of transdermal administration;
Accompanying drawing 5, be the experimental result picture of matched group;
Accompanying drawing 6, be experimental group (use micropin group) experimental result picture;
In above diagram:
1, hands handle; 2, roller mount; 3, needle body; 4, roller bearing; 6, support; 7, roller bearing hole;
9, the junction of handle 1 and support 6.
The specific embodiment
The present invention has studied existing Transdermal absorption device, and a kind of new Transdermal absorption product and structure and purposes are provided, and is convenient to the safe and effective use of industries such as improving looks, medical.
Skin needle roller is introduced existing micropin scroll techniques, and its device is transformed, and makes it to possess several functions.This apparatus can be applicable to the Transdermal absorption of beauty parlor, hospital, research institution and uses, and is conducive to improve the transdermal drag delivery system, and application prospect is preferably arranged.
In the present invention, the embodiment of the above-described specific embodiment and the following stated is all in order to set forth better the present invention, is not to limit scope of invention.The present invention is described in detail below by embodiment.
The present invention finally need to be prepared into the Transdermal absorption product and use, and the below will enumerate embodiment and further illustrate.If any problem, can contact directly 13386272938 or 15900897066 with the inventor.Provide several Transdermal absorption products and using method and some experimental study contents by aforementioned summary of the invention in the above-described specific embodiment and the following example, but the research contents that list in the place that should be appreciated that the present invention is not limited to this, should also be appreciated that term as used herein only is used for describing specific embodiment, and be not limitation of the invention.
Now with regard to apparatus of the present invention, specifically be described below:
Shown in Fig. 1 ~ 2, the present invention relates to a kind of skin needle roller, it comprises roller mount 2, be arranged at a plurality of needle bodies 3 on the external peripheral surface of described roller mount 2, the diameter of described each needle body 3 is 0.07 ~ 0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1 ~ 0.3 millimeter.The axial line place of described roller mount 2 offers roller bearing hole 7, can insert roller bearing 4 in roller bearing hole 7, and after being arranged on roller bearing 4 on support 6, roller mount 2 can be rotated around the Pivot Point Center line.The rear portion of support 6 has handle 1, the operator can hold handle 1 and promote it, support 6 is moved, the roller mount 2 that is pivotally connected on support 6 is namely rolled on the skin of human body, thereby extract rapidly after driving the epidermal tissue that needle body 3 pierces through skin, make 3 pairs of epidermises of needle body cause small wound and reach dermal tissue, and for the natural reaction to the epidermis tissue injury, dermal tissue namely can be made the epidermal tissue that makes new advances and go to repair these small wounds, thereby reaches effect young, health skin.
This skin needle roller can be applicable to massage health and the facial skin of human body, utilizes natural method to stimulate the ossein hypertrophy by needle body 3, and can not destroy skin epidermis, thereby promote the regeneration function of skin, reaches cosmetic result; This skin needle roller also can be applicable to massage the skin of head of human body, select the scalp massage of 3 pairs of human bodies of needle body of appropriate diameter, cause small wound by the epidermal tissue that gives scalp, can promote the blood circulation of scalp, stimulate the growth of hair, to reach the hair caring effect.
In the embodiment that the present invention adopts usually, described a plurality of needle bodies 3 are pressed 3 ~ 9 column distributions on roller mount 2.In following preferred embodiment, needle body 3 is distributed as 7 row, described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2, be that each individuality in every row needle body 3 is arranged along the circumferencial direction of roller mount 2 equally spacedly, this makes the present invention when using, the epidermal tissue of 3 pairs of skins of needle body causes uniform wound, and dermal tissue will produce uniformly new epidermal tissue, thereby can improve cosmetic result.
Utilize the device of technical solution of the present invention, particular content is as follows:
Get 8 stripped nude mice skin of back, process with transformation skin needle roller (500 μ m pins are long).The use dynamics is respectively 2.5,5,7.5,10,12.5,15,17.5,20N, and dynamics is controlled with electronic balance.With methylene blue solution dyeing 2 minutes, clear water washed away dye liquor subsequently.After above-mentioned skin is wiped moisture and residual dye with dry cotton ball, be cut into the fritter of 1cm * 0.5cm, after tissue immerses OCT liquid subsequently, liquid nitrogen cryogenics is freezing, spends the night, and cuts into slices under freezing state after taking out, and microscopically is observed length and the record of micro hole.Experimental result (table 1, Fig. 3):
After micropin roller transformation, during use, protective cover makes skin smooth, and rolling is easily carried out, and simultaneously, the diversity that micropin thrusts skin depth under identical dynamics reduces, and uses easy operating.
Table 1, micropin use dynamics and depth relationship research
The effectiveness of embodiment 2, transdermal administration (Franz diffusion cell method) research
Utilize the device of technical solution of the present invention, particular content is as follows:
Get 2 nude mice skins, remove subcutaneous tissue, normal saline flushing.Blank group is processed without micropin, and experimental group is processed with transformation micropin roller.Blank group and experimental group skin are fixed in Franz between coyote hole and receiving chamber, and stratum corneum side is to giving coyote hole, and effectively infiltrating area is 0.85cm
2Add in the receiving chamber water-alcohol solution (isopropyl alcohol: normal saline=1:1) until with skin close contact (4ml), get rid of bubble, be placed in (37.0 ± 0.5) ℃ water bath with thermostatic control, (200 ± 1) r/min constant speed electromagnetic agitation.0.2g tretinoin emulsifiable paste is applied on the Corium Mus horny layer, respectively at 1,2,3,4,5,6,8,10,12h takes out 0.2ml receiving liquid (replenishing rapidly the water-alcohol solution of equivalent after getting liquid), surveys concentration with HPLC.Calculate the accumulation infiltration capacity.The lucifuge operation.
Calculate each by accumulation infiltration capacity formula and accumulate infiltration capacity constantly.Formula is:
Wherein: Q is the accumulation infiltration capacity, receiving liquid Chinese medicine concentration when Cn is this sub-sampling, and V is acceptable solution volume in receiving chamber, and Ci is acceptable solution Chinese medicine concentration for for the first time to previous sample the time, and S is i sub-sampling amount.
After using transformation micropin roller, the drug osmotic amount obviously increases, and compares with experimental group and approximately improves 4 times of (see figure 4)s.
Utilize the device of technical solution of the present invention, particular content is as follows:
Process with repacking micropin roller after nude mice anesthesia, after processing, 3d puts to death nude mice, the skin histology of skin administration of learning from else's experience is fixing with 10% formaldehyde (PBS dilution), ethanol dehydration, paraffin embedding, section (5 μ m), put on microscope slide, HE dyeing, the reaction of microscopically tissues observed and inflammatory cell situation are taken pictures.Without the micropin processing is matched group.
The HE dyeing course:
1. hematoxylin dye liquor dyeing 5 ~ 15min.
2. flowing water rinses 3 ~ 5min.
3. 0.5 ~ 1% hydrochloride alcohol solution breaks up the several seconds.
4. flowing water rinses, and weak alkaline aqueous solution shows blue 1min.
5. eosin stain dyeing 10min.
6. washing, the dehydration of ethanol gradient, dimethylbenzene is transparent.
7. mounting, put on the table the absorbent paper of a cleaning, the microscope slide that will contain material takes out from dimethylbenzene and is placed on (section one facing up) on paper, promptly drip natural gum (must not carry out again) in the central authorities of section after the dimethylbenzene drying, hold with the right hand right side that pincet is clamped coverslip lightly, tilt to make a little its left side and envelope to hide agent and contact, and then put down lentamente, avoid producing bubble.
The HE coloration result: matched group (see figure 5) microscopically tissue is normal, uses micropin group (see figure 6) and matched group to organize without significant difference epidermal area and skin corium and does not show inflammatory reaction.
Claims (8)
1. a skin needle roller, is characterized in that, described this skin needle roller comprises fixed mount, two parts of needle roller;
Described fixed mount comprises handle (1), the support (6) by 1 flexible connection of junction (9) and handle, the roller bearing 4 that is connected with support (6);
The roller bearing hole (7) that described needle roller comprises roller mount (2), be arranged at a plurality of needle bodies (3) on the external peripheral surface of described roller mount (2), offer at the axial line place of roller mount (2); By roller bearing (4) with roller mount (2) pivotal mounting on support (6);
Described roller mount (2) is a hollow cylinder, and the material that uses has elasticity;
Described needle body (3) is hollow needle body, is directly fixed on the external peripheral surface of roller mount (2), distributes by multiple row.
2. micropin roller devices according to claim 1, is characterized in that, described handle (1) and the junction (9) of support (6) are that the embedded mode that adopts multi-faceted slip or multi-angle to move carries out activeness and is connected.
3. micropin roller devices according to claim 1, is characterized in that, described roller mount (2) is a hollow cylinder.
4. micropin roller devices according to claim 1, is characterized in that, described each row needle body (3) is pressed 3 ~ 9 column distributions on the external peripheral surface of roller mount (2), and evenly arranges along the circumferencial direction of roller mount (2).
5. micropin roller devices according to claim 1, is characterized in that, the diameter of described each needle body (3) is 0.07 ~ 0.35 millimeter, and the length of exposing at roller mount (2) Outboard Sections of described each needle body (3) is 0.1 ~ 3 millimeter.
6. according to claim 1 ~ 5 described micropin roller devices of any one are used for human body skin administration or cosmetics.
7. the application of micropin roller devices according to claim 6 is for human buttock or the direct administration fat-reducing of abdominal part.
8. the application of micropin roller devices according to claim 6 is for human body head or face's administration or cosmetics.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210545567.8A CN103120826B (en) | 2012-12-14 | 2012-12-14 | A kind of skin needle roller |
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| CN201210545567.8A CN103120826B (en) | 2012-12-14 | 2012-12-14 | A kind of skin needle roller |
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| CN103120826B CN103120826B (en) | 2016-04-20 |
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