CN103120826B - A kind of skin needle roller - Google Patents
A kind of skin needle roller Download PDFInfo
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- CN103120826B CN103120826B CN201210545567.8A CN201210545567A CN103120826B CN 103120826 B CN103120826 B CN 103120826B CN 201210545567 A CN201210545567 A CN 201210545567A CN 103120826 B CN103120826 B CN 103120826B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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Abstract
The present invention relates to a kind of skin-painless needle roller for rapid transdermal administration or cosmetics.The handle of this device fixed mount and support adopt multi-faceted slip or the mobile embedded movable connection method of multi-angle, roller mount adopts hollow cylinder, improve percutaneous dosing, Transdermal absorption, slow-releasing system, a large amount of microtubule can be made in the needle roller short time, medicine, cosmetics etc. directly be passed through epidermal area and skin corium cell; Epidermis wound is small, and healing is fast, and bacteriological infection probability significantly reduces, and skin can not be made hardening or cause cellular contraction, and epidermal tissue also can not be thinning, can repeatedly use; Also can be used for massaging scalp, stimulate natural on-off cycles of hair growth.Preparation technology of the present invention is simple, inexpensive, and side effect is low, and successful is better handling, easy to use, can grasp through simple training, practical, can daily life be directly used in, be more suitable for large-scale production and the business application of the industry such as medicine, beauty treatment and industry, remarkable benefit.
Description
Technical field
The present invention relates to the technical field such as medicine, beauty treatment, specifically relate to a kind ofly give the painless doser of medicine, cosmetics etc. and structure thereof and purposes through skin, more particularly relate to a kind ofly reach rapid transdermal for transdermal administration or cosmetics and absorb or the skin-painless needle roller of the good result such as slow release and structure thereof and purposes.
Background technology
(1) research overview of micropin roller
1, summarize
21 century, medical circle is encountered by a new problem at medical domain: how medicine is correctly transported to the position needing to treat, drug effect is maximized play.Beauty treatment circle also faces same problem, more why be known as the first-class and products such as expensive beauty cream, cosmetic cream of high-tech nanotechnology, raw material after a procedure, effect is not expectative so obvious, so medical circle is unprecedentedly active about the research that percutaneous dosing, Transdermal absorption, slow release etc. are academic in recent years.Gene biological cosmetics can carry out reformation reparation to Skin Cell, but the position how be transported to by these compositions required for skin is to cell metabolism generation effect, becomes a difficult problem of gene biological beauty treatment.
Horny layer is the protective layer that skin surface is the firmest; also be that nutrient in general cosmetics can not go directly the major obstacle of skin bottom; medical circle constantly seeks new method, allows the nutrition of beauty treatment aging resistance penetrate horny layer, directly enters skin layers generation effect.Beauty apparatus many on the market is all through ultrasound wave intermediate frequency unidirectional current, attempts to strengthen nutrient substance and passes through cuticular ability; How, effect is also not remarkable all the time, and this kind of technology of life-time service also can cause corse sweat pore.
Along with growth in the living standard, people to make skin rejuvenation, health demand increasing, in order to make skin reach cosmetic result, at present conventional method has: grind off epidermis, pickling, laser removes epidermis etc.The common ground of these methods is: they are all the epidermal tissues of removing skin surface, make the epidermal tissue that the dermal tissue manufacture below epidermal tissue makes new advances, thus reach the effect making skin more healthy and smooth.But, these methods are used also to there is a lot of drawback to skin, the epidermis of human body is that people resists the extraneous outermost layer barrier infected, and to be removed and new epidermal tissue not yet grows in complete process in old epidermal tissue, and skin is very easily subject to the infection of antibacterial and diseases induced; On the other hand, the convalescent period of these Therapeutic Method is long again, is generally the several months; Further, the skin through these method process can be thinning, if overtreating also possibility scar, so for most people, these Therapeutic Method can only use once at most.
2, the definition of moulding of micropin U.S.A and principle
By the development of science and technology, laser beautifying is becoming the first-selection treatment of female skin aging, mottle, wrinkle etc. symptom with brand-new attitude.And biological beauty and skin nursing are also just constantly being innovated with completely new concept and technology, biological beauty is being China's popular new technique instantly, particularly micropin beauty treatment, one of popular new technique first-elected especially, and its successful is simple to operate,
Now approved by vast beauty treatment mechanism, but pain is still the major issue that microneedle therapy faces, the painless micropin of follow-up release can solve problems effectively, and it is one wherein that micropin U.S.A moulds.
Micropin U.S.A moulds beauty treatment and comes from the U.S., also known as micropin mesoderm beauty curing (mesotherapy), or claims microneedle therapy (to be called for short: MTS).
It is the micropin that rolls on skin that micropin U.S.A moulds, micropin roller is used to stimulate human body skin, within very short time, micropin can produce more than 200 between skin aspect, 000 fine conveyance conduit, make the various active composition such as Growth of Cells peptide gene active component and multi-nutrition element directly effectively infiltrate deep skin, product assimilation effect is more than 4000 times of common spread product; Be equipped with wrinkle removal, speckle dispelling, whitening, repair, the product such as striae gravidarum, scar eliminating of dispelling, can efficiently repair rapidly, active cell, promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination cicatrix, mottle, smooth out wrinkles, thus reach and subtract light wrinkle, treatment cicatrix, anti-acne, anti-acne print and striae gravidarum, skin whitening, subtract light color speckle, improve eye wrinkle-removing, black eye, tighten up and promote the ideal effects such as skin of face tissue.
The principle that micropin U.S.A moulds is a kind of therapy of carrying out improving looks for skin mesoderm, this therapy is that skin care activity composition or nutritional labeling are input to mesoderm by certain special installation (that is: instrument is moulded by U.S.A) and are played a role, and this U.S.A to mould instrument be exactly micropin roller (B.N.MmesoRoller or MesoRoller, sometimes be also called for short: micropin) or U.S.A mould rifle (MesoGun), different equipment has different action principles: micropin roller utilizes many little pins (small syringe needle) on roller to penetrate horny layer, chafe, within very short time, micropin can be made and exceed millions of ultra micro tubules, be equipped with wrinkle removal, whitening, repair, to dispel striae gravidarum, the specially good effect products such as scar eliminating, active component is made effectively to infiltrate the importing of skin and aidant component, thus reach and subtract light wrinkle, treatment cicatrix and striae gravidarum, skin whitening, subtract light color speckle, improve eye wrinkle-removing and black eye, tighten up and promote the ideal effects such as skin of face tissue, simultaneously micropin stimulates skin corium, percutaneous self-healing ability, promotes ossein hypertrophy, can make the thickness hypertrophy about 8% of skin epidermis, and its effect can match in excellence or beauty the plastic operation of laser and filled type.And the microsyringe of Mei Suqiangshi automatization, directly component injection to subcutaneous.These two kinds of equipment can be selected according to the needs of self, and the safety of micropin roller is high, easy to use, is widely used, and U.S.A mould rifle mainly tackling partial-depth wrinkle and local weight reducing fat melting in have some superiority.
Micropin U.S.A mould be utilize a kind of deep layer be used for aesthetic nursing is carried out to skin, compared with superficiality nursing in the past, this treatment can reach effect more thoroughly, but also can ensure can not cause extra infringement to skin, so be a kind of desirable beauty treatment means.
The passage can opened instantaneously towards skin basal layer is moulded by micropin U.S.A, somatomedin is transported to skin bottom endlessly: own cells regeneration can be activated, strengthen self synthesis and Secretion, endogenous replenishing collagen and elastic fibers, remove interior free yl, reduce biological oxidation and aging; Can directly act on basal layer melanin, check melanin generates, spot fading, accelerates metabolite and transports, remove and cause the free radical of human senility, thus delaying skin aging, and that skin and muscles are fair is smooth, fine and smooth in silk in order; Wrinkle removal simultaneously skin becomes delicate smooth and compacts beautiful, strong division and the growth promoting Skin Cell; Irritate synthesis and the secretion of hyaluronic acid, collagen protein and glycoprotein etc., make wrinkle of skin Lock-out, skin recovers gloss and elasticity, is applicable to the dark person of local wrinkle.While micropin chafe, can also stimulate the hypertrophy of skin corium collagen and fibroblast, not only small wound healing is rapid, and preventing from scar.
Micropin U.S.A moulds and effectively can improve the face skin problems such as sunburn, chloasma, freckle, plumbous mercurialism, facial pigmentation skewness, the colour of skin are dark and gloomy, the coarse tarnish of skin; For acne pothole skin, contained biology dispel acne pothole skin-active composition directly act on deep skin fracture fibrocyte, promote collagen protein synthesis, regenerate fibrous tissue, thus arrive the reconstruction of deeper reticular fibre structure, calm down acne pothole, reappear smooth fine and smooth skin.
3, the characteristic of micropin beauty treatment
Effect of micropin beauty treatment and feature:
1. utilize the normal healing ability of wound, skin can not be made hardening or cause that Skin Cell shrinks.
2. micropin can make a large amount of microtubule, makes active component effectively infiltrate skin (only need use five minutes, just can produce more than 200,000 micropore).
3. side effect is extremely low.
4. nurse simple and easy after using microneedle theraphy, can general outdoor activities be carried out, comprise and getting sun.
Advantage is moulded by micropin U.S.A:
Naturality: do not affect histrionic muscles and face nerve, natural shape of expressing one's feelings after reduce wrinkle harmony.
Safety: with human body homology, without obviously rejection and side effect, leaves no trace after treatment, cicatrix, safe and reliable.
Persistency: promote human body cell continuous release collagen protein, elastin laminin, curative effect is permanent.
Simplicity: with doing with walking, noinvasive is painless, does not affect work and life, also referred to as " lunch break erugation ".
High efficiency: dispel true property wrinkle and reach more than 95%, reverses old and feeble, young 5 ~ 10 years old.
The problem that micropin roller solves:
1. subtract light wrinkle, bring out ossein hypertrophy, treatment areolar tissue, skin thickness problem, treatment cicatrix and striae gravidarum;
2. skin whitening, subtracts light color speckle, improves eye wrinkle-removing, black eye, stimulates ossein hypertrophy, tightens up and promote skin of face tissue;
3. administer alopecia, care and household etc. and effectively carry nutrient.
Now a lot of cosmetics all have damage in various degree to skin, concerning using a kind of beyond doubt injury such personage that likes to be beautiful, so they are more careful when selecting cosmetics, and the harm that micropin U.S.A moulds is almost non-existent, be substantially without a kind of more safe and reliable beauty method damaged to skin.
Micropin U.S.A mould be by U.S.A mould instrument nutrient needed for skin imported make skin fully absorb in the skin that needs to change after reach cosmetic result, it is different from other beauty method, be need not operate on, need not take medicine, accurate effective beauty method, it is a kind of point-to-point beauty method: the integrity not destroying skin texture, set up a large amount of skin microtubules, transport substrate cosmetics; Progressively remove deep skin toxin and refuse; Chafe self-healing ability, promotes skin metabolism, keeps skin elasticity and handsome U.S.; Active cell, reparation damaged tissues, participate in cellular metabolism directly, reach wrinkle removing, lifting, whitening, antidotal effect; Utilize the normal healing ability of wound, the nutrition of induced skin self and collagen growth; Safe and reliablely to have no side effect.
The harm that micropin U.S.A moulds thus is almost non-existent, by time short, the instant effect of its beauty treatment, without cicatrix, all applicable to the crowd of various skin problem.
The rise that micropin U.S.A moulds, solves the century difficult problem on the world of medicine, beauty treatment circle.Use B.N.MmesoRoller chafe, make a large amount of microtubule, make active component effectively infiltrate skin.Trickle rolling acupuncture simultaneously, can also stimulate the hypertrophy of skin corium collagen protein and fibroblast.This kind of Wicresoft is that use is also less than 30G fine needle " micropin " carry out aculea action, not only " Micro trauma " healing is rapid, and preventing from scar.In other words, directly by Growth of Cells peptide gene active component and multi-nutrition element etc., the skin cell rapid osmotic of different depth is given via very tiny pin hole.The wound that these tiny Wicresofts can't cause skin excessive and burden, in reparation period, can also activating cell, promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination pox scar color element; + 6 also can allow Skin Cell directly absorb the gene activity composition of skin needs through microtubule, and assimilation effect, close to absolutely, therefore can give different formula for demands of individuals, really make new skin live again from inside to outside, thoroughly improve skin quality.
4, micropin roller
(1) textual investigation
Micropin roller is that instrument used is moulded by micropin U.S.A.Micropin, needle set name, the appearance of micropin one word, can find at Huangdi's Internal Classics, and it refers to the fine fine little needle sets such as acupuncture needle." the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " in Huangdi's Internal Classics: " for leading to its passages through which vital energy circulates with micropin, adjusting its vim and vigour ... ", nowadays, micropin is just widely used in beauty treatment.
The justice of micropin has two:
1. small pin, little pin." Plain Questions treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it is controlled should micropin." Wang Bingci note: " micro-, also tiny.Tiny pin, pulse-taking declines and contains also." " the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint ": " and wanting of little pin, easily old and difficulty enters." " class is through 19 volume acupuncture classes one ": " little pin, the i.e. meaning of micropin above.”
2. nine kinds of needles." Plain Questions treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it is controlled should micropin.Therefore nine kinds of needles person, also come from south." " Plain Questions knowledge ": " [nine kinds of needles], high cloud: ' " Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles opinion " Yellow Emperor, a legendary ruler is for leading to its passages through which vital energy circulates with micropin.Micropin, little pin also.The qi uncle little pin of opinion and and in nine kinds of needles, therefore the person that says nine kinds of needles, also comes from south.' letter presses: " the nine kinds of needles twelve source acupoint ": ' Supreme Being asks useless stone needle, for leading to its passages through which vital energy circulates with micropin.And qi uncle answers to start from one finally nine.' then micropin be namely nine kinds of needles, for stone needle, outside non-nine kinds of needles, have micropin.Will cloud: ' micropin person.Its cutting edge of a knife or a sword is fine.The pin of shallow puncture also.' be probably non-ly.”
Micropin roller is the invention of medicine in France expert Horst doctor the earliest, adopts Switzerland's high-quality medical treatment rustless steel, continues to use the casting method of German craftsman invention in 1896, form the supercool freeze techniques manufacture of subzero 60 degree Celsius.So, the very high purity of micropin, very hard.
Current a micropin roller is based on the Anti-slip handle of bionic design, and the pure moulding of streamlined fashion, not run-bake-needle fault, needle point is round and smooth sharp, is the latest generation micropin roller of current leading industry.
(2) basic structure and specification
With the micropin that a lot of diameter is the same with spacing on micropin roller, the different needle roller then spacing of its micropin and diameter understands that some is different, and being needs to select according to skin conditions the micropin specification that is applicable to, the micropin of to be generally pin length be 0.3 ~ 1.25mm.The stimulation of longer micropin to skin is more deep, also relatively high to treatment personnel technical requirement, and not the longer the better to treat the micropin used; If be not suitable for the skin thickness of patient, that effect can only be reciprocal, because it is by micropin thorn expelling pathogenic factors from the exterior skin that the principle worked is moulded by micropin U.S.A, import the essence being applicable to related dermal problem or medicine etc. again, allow essence or medicine etc. directly penetrate within epidermis like this, improve and repair cortical tissue and cell.
So such thorn permeability treatment needs in medical cosmetology mechanism, allow the doctors and nurses of specialty operate, people one pin, strict sterilization, does not reuse, the safety of guarantee treatment.
Micropin specification (mm and millimeter are the length of pointer, are not the width of roller):
1. 0.25mm: be generally used for red blood streak, cell is more raw;
2. 0.5mm: be generally used for wrinkle removal, whitening, speckle dispelling, receipts fine, soft fur hole;
3. 1.0mm: be generally used for recessed scar, pox hole, cicatrix reparation;
4. 1.5mm: be generally used for striae gravidarum.
(3) related products
Have the product of report at present, such as Mesomed micropin rod makes with plastic cement, and volume is light and handy, about 200 the very tiny medical titanium syringe needles of upper EDS maps.
A kind of commercially available micropin roller product section details is as follows:
Weight: 55 grams (comprising packaging)
Package size: 16cm × 3.5cm × 5.5cm
Color: white orange or transparent orange
Micropin material: medical use rustless steel (silver)
Micropin arranges: yi word pattern is in line
Ai: EQGas, the Gamma that disappears disappears Ai ray, ethanol, and UHT high temperature disappears Ai
Namely abandon: be (unless again disappeared Ai)
Pin is long to be selected: 0.2mm/0.25mm/0.3mm/0.5mm/0.75mm/1.0mm/1.5mm/2.0mm/2.5mm/ 3.0mm
OEM/ODM selects: passable
Environmental conservation: qualification greening material
Specification: ISO11137, CE, FDA
Micropin quantity 540 on micropin roller, pain reduces by half than common micropin; Kermesinus roller, bright pearl white handle.
The solid roller design of this product, guarantees use safety.
The solid roller design of Britain's micropin is derived from the requirement of FDA and CE blueprint, and have employed jointless technique and produce and guaranteed that antibacterial can not grow at roller after sterilization, and more stopping to appoint can the disaster of bacterial invasion.Occurred that some are convenient to the low cost hollow roller micropin produced recently on the market, hollow roller can lower the trouble much installed undoubtedly, but this design but has health test problems large absolutely.Such as in nursing course for the treatment of, careless be coated with upper surface portion skin care item or micropin on the remaining fine blood streak also can enter the middle part of roller through the joint close on hollow roller.If disappear, Ai does perfect not, and the micropin roller that this FDA of not meeting or CE requires definitely likely makes skin be subject to the crisis of bacterial invasion and leave behind permanent injury.
The whole handle of micropin is through and meets that ergonomic designs requires, this design effectively can reduce strain on finger and the grip increased between finger tip and handle and avoid having unclamped because of carelessness the injury (such as barefoot hands is slippery absent-mindedly) that handle can make.The material that micropin uses can bear high temperature, heat-resisting not modification.
A kind of Product Report of painless aculea rolling instrument is had to claim: the life-span of high-quality micropin roller and effect are determined by the material of micropin itself and the grinding state of needle point.192 micropins of the painless micropin roller of this product are made up of Korea S's high density medical stainless steel, in conjunction with international advanced pin technology processed, draw point is hard, and it is carefully atomic, so the pain of client can not be caused when thrusting skin, the needle roller of 0.25mm length could reach 100% painless, and the common needle roller of more than 0.5mm painless needle roller contrast same specification can make client's pain reduce by more than 50%!
Also have a kind of Product Report to claim: the structure of skin needle roller is composed as follows: needle body adopts selects 0Cr19Ni9 in GB/T4240 " stainless steel silk " or other austenitic stainless steel wires, through sharpening, injection moulding, inlay, assemble, the operation manufacture such as heat-sealing forms.It is 0.2mm, 0.3mm, 0.5mm, 1.0mm, 1.5mm, 2.0mm that this product exposes the needle body length that roller sheet surveys outward; Needle body diameter is 0.16mm, 0.18mm, 0.20mm, 0.22mm, 0.25mm, 0.30mm; The technical parameter of this product is: the numerical value of needle body hardness >=460HV, 0.2kg surface roughness Ra is not more than 0.5 μm.The design of needle roller spreads all over intensive, and pin and pin only have 0.3mm apart, can reach the optimal healing effect to wound.
(4) RELATED APPLICATIONS application
There is patent of invention " a kind of miniature needle roller " (application number: 200810089036, the applying date: 2008-04-16) claim: a kind of miniature needle roller, comprise multiple fine needle substrate 10, cylinder substrate 20 and pair of discs 30, described fine needle substrate 10 is made up of the multiple microneedle 11 configured at a certain distance, and there is jut 12 lower end, both sides of fine needle substrate 10; The both sides of described cylinder substrate 20 are provided with patchhole 21, and the jut 12 of lower end, fine needle substrate 10 both sides can directly be inserted in this patchhole 21; Described disk 30 comprises the fixing insertion section 31 of annular.After described whole cylinder substrate 20 and fine needle substrate 10 combine, both sides in conjunction with protuberance 13 formed one overall in conjunction with fixed part 22, be inserted in the fixing insertion section 31 of above-mentioned disk 30, when preventing from rotating, fine needle substrate 10 and cylinder substrate 20 depart from.Adopt after the present invention, its simple and convenient assembly, to save time and laborsaving, reach the effect that fraction defective is minimum, productivity ratio is the highest.In addition, the effect that when can also reach pre-anti-rotation, fine needle substrate and cylinder substrate depart from mutually.
There is utility model patent " skin needle roller " (application number: 200720035626.1, the applying date: 2007.03.23) claim: a kind of skin needle roller, it comprises roller mount, the multiple needle bodies be arranged on the external peripheral surface of described roller mount, the diameter of described each needle body is 0.07 ~ 0.35 millimeter, described each needle body to expose in the length of roller mount Outboard Sections be 0.1 ~ 3 millimeter.Needle body is driven to roll on the skin of human body by roller mount, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thus chafe, promotion ossein hypertrophy, for the natural reaction to epidermis tissue injury, dermal tissue can manufacture the epidermal tissue made new advances, thus reaches the effect of health rejuvenation skin.Using this skin needle roller, can reach without the need to removing epidermal tissue the effect that epidermal tissue is regenerated, and due to epidermis wound small, quickly, the probability being subject to bacteriological infection is also lowered healing stage; In addition, it also can not make epidermal tissue thinning, can repeatedly use.This skin needle roller is easy to use, and application risk goes the method for epidermis far below tradition.
(5) up-to-date basic technology progress
" Science and Technology Daily " December in 2011 reports on the 23rd: engineer develops painless silk micropin, can accurate Drug controlled release.Organize 22 (Beijing time) of net December according to American Physical scholar, engineering college of Tufts University of U.S. bioengineer develops a kind of painless silk microneedle device, can by sustained release in long-time, without the need to the medicine that cold preservation is unnecessary.This micropin has biocompatibility and biological degradability concurrently, can manufacture under normal temperature and pressure, can load the biochemical drug that is easily damaged and keep it active.On correlative theses is published in " advanced function material " website.
Demonstrator Trials shows, New type silk micropin can send macromole, catalator medicine, horseradish peroxidase with controllable speed, also keeps the biological activity of medicine simultaneously; The silk micropin loading tetracycline can also suppress the growth of staphylococcus aureus, shows that this micropin is while delivering therapeutic agents, also has the potential value of prevention local infection.
Although some medicine can directly be swallowed, some cannot bear gastrointestinal digest and decompose.Hypodermic Method compare is painful, can not slow releasing medicine.Only have little small-molecule drug to enter in body by the mode sticked.Silk micropin only 1 micron of size, penetrating overlaying skin and can not touch nerve, is a kind of new painless type mechanisms for drug release.But have an a lot of difficult problem to hinder the development of this technology at present, the vulnerability as biological product make medicine in the fabrication process loss of activity, can not accurate Drug controlled release or put the infection etc. that too much, the small skin penetration of medicine brings.
For these problems, research worker have developed new fabrication schedule, and process comprises pressure, temperature and water treatment etc.They are formed from aluminium micropin master mold, line up 500 microns high, and needle type radius is less than the array of 10 microns; (be called for short: PDMS) be cast on master mold and form die with resilient dimethione; Again the silk protein solution that medicine is housed is injected die.When after silk drying, then the silk micropin comprising medicine is taken off further processing.Post processing comprises makes it limber up with steam, then passes through the various process of temperature, machinery and electronics, makes it have corresponding diffusibility and drug releasing rate.
Research worker represents, regulates the post-treatment condition of fibroin, as changed drying time, mainly controls its secondary structure, with energy accurately Drug controlled release speed.Through the test of release dynamic model, drug releasing rate can reduce by 5.6 times, which solves a drug release difficult problem for a long time, can also be used in other biological storage aspect.
Paper co-author, Ta Fusi biomedical engineering chairman David Kapp orchid are also pointed out, this micropin is very flexible, can expand or reduce, transports or store without the need to cold preservation, and it is easy just as plaster or binder that management is got up.
The thing of microneedle therapy non-fresh." the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " of ancestor just has cloud: " for leading to its passages through which vital energy circulates with micropin, adjusting its vim and vigour ... ".Although the size of those micropins and the present pinpoint array less than 10 mu radius cannot compare really, the principle of from outward appearance to inner essence curing the sickness to save the patient, broadly similar.As for the main innovate point of Tufts University, in fact show that they select silk and organosilicon to make base material, utilize material behavior to realize slow release, controlled release.Healing when microneedle therapy becomes when maturation, examination water can not be patient of hanging down, but large quantities of wish is the woman that happy own person holds.
(2) research overview of needle roller
1, summarize
The product somewhat similar with micropin has the device containing needle roller, is a kind of machinery for the particularly Suzhou embroidery skill of handling needles of embroidering.
2, needle roller
Needle roller (needleroller) refers to the small diameter cylinders roller that length-to-diameter rate is greater than 2.5, belonging to the rolling bearing (three grades of subjects) in the mechanical machine components of first level discipline (secondary subject) of application branch of learning, is the one in the sewing of one of Suzhou embroidery skill of handling needles bar.This needle roller is suitable for palpus, the eyebrow of embroidered beast, the hair of personage, the pleat stricture of vagina of clothes and carefully narrow pattern line kind etc.The tight Jing'an of two lines, becomes striped, and lines turnover is more flexible.Embroider straight line, curve all more appropriate.
Stitching step: fall after rising before grain pattern lines, pin pin is tightly secret, and lines length is same, and about one city divides left and right.Turning point can be slightly short, so that turnover.Embroider after the first pin, second should fall at the first pin 1/2nd place pin, and needle tracking is ensconced under last pin.3rd pin drops on 1/2nd places of the second pin, the tight end by the first needlework bar, by that analogy.
Needle bearing (needlerollerbearing): refer to that rolling element is the radial bearing of needle roller is the roller bearing of band cylindrical roller, its diameter relatively, and roller is thin but also length not only.This roller is called needle roller.Although have less cross section, bearing still has higher load-taking capacity, therefore, is specially adapted to the restricted occasion of radial space.
Needle roller contoured surface shrinks a little at proximal end face place.The result of needle roller and Race Line Contact correction can be avoided producing damaging edge stress.Supporting rollern needle bearing system's heavy wall outer ring, through the quenching of high temperature height nitrogen, the roller of high-accuracy sorting, by the lip-guided of high rigid external collar, utilizes wire-shaped contact, and roller can direct ease rotation on raceway, and can bear huge load.For removing stress, the outer ring of support roller adopts cambered surface design, and curving roll has the single, double sealing ring of band, is not with sealing ring, is with all size models such as sealing ring.Band sealing ring store grease space large, provide lithium saponify permanence to lubricate, and extend lubricating interval.Sealing ring material is band skeleton acrylonitrile-butadiene rubber or ST12, and its operating temperature range is-30 DEG C to+100 DEG C or-30 DEG C to+180 DEG C.The curving roll of closely packed formula can bear heavier extremely strong load and high performance operation.RSTO outer ring without rib, without inner ring supporting rollern.
The feature of needle bearing and purposes:
Needle bearing is equipped with thin and long roller, and (roller length is 3 ~ 10 times of diameter, diameter is generally not more than 5mm), therefore radial structure is compact, when its internal diameter size is identical with other types bearing with load-carrying ability, external diameter is minimum, is specially adapted to the restricted supporting result of radial installation dimension.Different according to use occasion, can select without the bearing of inner ring or needle roller and retainer assembly, the journal surface now matched with bearing and shell aperture surface are directly as the inside and outside rolling surface of bearing, for ensureing that load-carrying ability is identical with there being lasso bearing with behavior in service, the hardness of axle or shell aperture raceway face, machining accuracy and surface quality should be similar with the raceway of bearing ring.This kind of bearing only can bear radial load.
The type of needle bearing:
Can be used for the bearing of common engineering, as: open type drawn cup needle roller bearing, closed drawn cup needle roller bearing, tool inner ring needle bearing and do not have inner ring needle bearing/without inner ring without retainer needle bearing, have retainer and fill needle bearing without retainer.
Although above-mentioned needle roller device is different from technical field of the present invention, technically also still there is the place that can be worth reference and reference with beauty treatment skin needle roller of the present invention at product manufacturing.
Therefore, find novel, Transdermal absorption better effects if, use that skin-painless needle roller is still imperative more easily.
By literature search etc., up to the present, the skin-painless needle roller product of renewal and the report of the aspect such as structure and purposes thereof is not yet found that there is.
Summary of the invention
The technical problem that will solve required for the present invention discloses a kind ofly to reach a kind of skin-painless needle roller of the good result such as Transdermal absorption, slow release and structure thereof and purposes for transdermal administration or cosmetics, namely this device has the new roles such as Quick medicine, easy to use, infection chance is few, can be used in the technical field such as medicine, beauty treatment, to overcome the above-mentioned defect that prior art exists.
That is, the present invention is directed to the deficiencies in the prior art, by the practical studies such as zoopery and clinical trial and theory study, one of object is intended to provide a kind of new doser, namely provides a kind of safer, more convenient, skin-painless needle roller of more easily manipulating; Two of object of the present invention is to provide a kind of purposes of new micropin tourelle.
Skin needle roller of the present invention (also claims: skin needle roller device, micro-needle roller device sometimes, skin micro-needle roller device, micropin tourelle, skin micropin tourelle, needle roller device etc.) refer in the technical field such as medicine, beauty treatment, a kind of product being directly used in quick, painless Transdermal absorption; Preferably be directly used in the product of beauty industry, i.e. the U.S. molding product of a kind of new micropin.
(1) technical conceive
Explore and improve the urgent task that existing micropin technology and supporting skin needle roller are Chinese medical, beauty industry safety, Quick medicine or cosmetics, particularly to study and improve the subcutaneous location that medicine, cosmetics correctly can be transported to fast and need to treat, effect is maximized, be the forward position of the academic researchs such as percutaneous dosing, Transdermal absorption, slow release, a difficult problem of biological beauty can be solved.
Horny layer is the protective layer that skin surface is the firmest; also be that effective ingredient in general medicine, cosmetics etc. can not go directly the major obstacle of skin bottom; medical circle, beauty culture are all constantly seeking new method; allow relevant effective ingredient penetrate horny layer, directly enter skin layers generation effect.
In actual use, inventor finds existing skin-painless needle roller, such as general skin skin needle roller, when particularly facial skin uses in use, when processing skin, higher to operation requirements: one is when dragging skin skin needle roller back and forth, skin creases easily, if excessive velocities, cause hemorrhage or pain, need to take moderate speed; Two is need skin surface to be processed likely uneven, particularly in face, in the process dragged, often needs the angle and direction converting dragging at any time, increases the uncontrollability of operation, improve the requirement of operation; Three is that the needle body length of same skin skin needle roller is fixed, to different parts or the different demand of same client, often need to use two or more skin skin needle roller, increase customer cost, use different skin skin needle rollers in turn, too increase the chance that may cause infection; Four is need first to process skin, behind a large amount of trickle duct of formation, could administration or cosmetics etc., and be difficult to carry out, operation is not in time or other are improper, adds the chance that may cause infection simultaneously.
Therefore, for reducing infection chance, improving safety, increase the convenient of manipulation, convenient more people use, and are particularly convenient to client oneself and directly use this skin needle roller, according to this idea and thinking, inventor has consulted a large amount of data, the existing various product of comparison, by experimentation repeatedly and analysis and theory study, successfully obtains the result of study of expecting and application product.
The present invention mainly carries out improving for utility model patent " skin needle roller " (application number: 200720035626.1, the applying date: 2007.03.23), and expands its purposes to multiple technical field such as medicine, beauty treatment.
Particularly woman's beauty treatment of improving looks is the focus that the whole world is all concerned about, rapid transdermal administration, Transdermal absorption, slow release etc. are also the focuses of pharmaceuticals industry general concern.Healing when microneedle therapy becomes when maturation, will have more large quantities of woman for holding for happy own person.If spread uses skin needle roller of the present invention, this technology will have significant social benefit, economic benefit.
(2) skin needle roller and uses thereof
The present invention has carried out many-sided test and study to skin needle roller at beautifying skin, rapid transdermal administration, Transdermal absorption, slow release etc. and has explored.
Technical scheme of the present invention is as follows:
A kind of skin needle roller, it comprises fixed mount and needle roller two parts:
The support 6 that described fixed mount comprises handle 1, be flexibly connected with handle 1 by junction 9, the roller bearing 4(be connected with support 6 are shown in Fig. 1);
Described handle 1 preferably adopts multi-faceted slip or the embedded mode of multi-angle movement can carry out activeness with support 6 and be connected, and the handle 1 is namely adopt the embedded mode of multi-faceted slip or multi-angle movement to carry out activeness to be connected with the junction 9 of support 6;
Described handle (1) and the junction (9) of support (6) are the connections adopting the embedded mode of multi-faceted slip or multi-angle movement to carry out activeness to be connected;
Described needle roller comprises roller mount 2, the multiple needle bodies 3 be arranged on the external peripheral surface of roller mount 2, the roller bearing hole 7 offered at the axial line place of roller mount 2; By roller bearing 4, roller mount 2 is pivotally mounted on support 6, is convenient to control roller mount 2 by the mode pushed away or draw and rolls on human body skin (see figure 2);
Described roller mount 2 is hollow cylinders, preferred cylinder; Needle body 3 is hollow needle body; And each row needle body 3 is directly fixed in roller mount 2, by multiple row distribution on the external peripheral surface of roller mount 2, preferably by 3 ~ 9 column distributions, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2; The material that roller mount 2 uses has elasticity, and when dragging apparatus of the present invention, under the pressure dragged, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3;
The diameter of described each needle body 3 is 0.07 ~ 0.35 millimeter, described each needle body 3 to expose in the length of roller mount 2 Outboard Sections be 0.1 ~ 3 millimeter; Drive needle body to roll on the skin of human body by roller mount 2, needle body can pierce through the epidermal tissue of skin, causes small wound, then reach dermal tissue to it.
The present invention is mainly used in the percutaneous drug delivery or cosmetics etc. at the position such as health, face of human body, can be used for human buttock or the direct administration of skin of abdomen to reach the effect of quick weight-lossing, is preferred for the percutaneous drug delivery or cosmetics etc. of human face; And except the skin of health and face, also this skin needle roller can be applied to massage skin of head, with blood circulation promoting, stimulate the growth of hair.
Existing skin needle roller (application number: 200720035626.1, the applying date: 2007.03.23) comprises fixed mount and needle roller two parts, and described fixed mount comprises handle 1, roller bearing 4, support 6; Described needle roller comprises roller mount 2, needle body 3, roller bearing hole 7; Each modular construction and basic annexation as follows:
Described handle 1 is fixedly connected with support 6, and support 6 is connected with roller bearing 4; Described roller mount 2 comprises multiple wheel sheet 5 in the form of annular discs, described multiple sheets 5 of taking turns are arranged in order and connect in end, described multiple needle bodies 3 are by multiple row distribution on the external peripheral surface of roller mount 2, and each row needle body 3 is fixedly clamped respectively between adjacent wheel sheet 5; Offer roller bearing hole 7 at the axial line place of described roller mount 2, by roller bearing 4, roller mount 2 is pivotally mounted on support 6, be convenient to control roller mount 2 by the mode pushed away or draw and roll on human body skin;
The diameter of described each needle body 3 is 0.07 ~ 0.35 millimeter, described each needle body 3 to expose in the length of roller mount 2 Outboard Sections be 0.1 ~ 3 millimeter;
Preferably: described multiple needle bodies 3 usually press 3 ~ 9 column distributions in roller mount 2, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2.
The present invention improves following two aspects:
The one connected mode (see figure 1) being the improvement handle 1 and support 6, namely handle 1 adopts revocable movable connection method with the junction 9 of support 6, and namely handle 1 adopts multi-faceted slip or multi-angle can move embedded mode and carry out activeness with support 6 and be connected; This improvement solves the problem being difficult to arbitrarily conversion dragging angle and direction, adds handling, is easier to use;
Two is that improvement roller mount 2 and needle body 3(are shown in Fig. 2), described roller mount 2 is hollow cylinders, no longer comprises multiple wheel sheet 5 in the form of annular discs, preferred cylinder; Needle body 3 by solid change into hollow; And each row needle body 3 is fixedly clamped respectively and changes each row needle body 3 into be directly fixed in roller mount 2 between adjacent wheel sheet 5; The material that roller mount 2 uses has elasticity, and when dragging apparatus of the present invention, under the pressure dragged, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3.Adopt single use mode, can not the problem of administration simultaneously or cosmetics when this improvement just can solve process skin, decrease operation sequence and infection chance, be more convenient for using, be easy to popularization.
Improve as can be seen from above population structure and introduce and the elaborating further of technical scheme, micropin tourelle be a kind of novel for improving looks, the device of the purposes such as administration, can be used in the aspects such as the beautifying skin of client or patient, percutaneous drug delivery, not only structure simply, easily operates, usage charges are low, and firmly symmetrical stable, dragging speed can self regulation, decreases the chance of infection, use safer, improve can be handling.
(3) technology speciality
The apparatus that the present invention is medical treatment, beauty industry provides a kind of new beautifying skin, percutaneous drug delivery, thus need the system such as subcutaneous location, particularly percutaneous dosing, Transdermal absorption, slow release treated improve and improve to medicine, cosmetics being correctly transported to.The present invention is safe and effective, and practicality is comparatively strong, and its preparation technology is simple, inexpensive, simple to operate, convenient and swift, can grasp, can be directly used in daily life through simple training.
Advantage of the present invention is: needle roller therapy utilizes the normal healing ability of skin to complete, and skin can not be made hardening or cause the contraction of Skin Cell, and needle roller can make a large amount of microtubule, is beneficial to medicine, nutritional solution etc. directly to infiltrate subcutaneous.After using needle roller treatment, nursing is simple and easy, can carry out general outdoor activities, comprise and getting sun.In addition, this skin needle roller also can not make epidermal tissue thinning, can repeatedly use.This skin needle roller is easy to use, because epidermis wound is small, healing stage quickly, the probability being subject to bacteriological infection is also lowered, this skin needle roller far below the method for traditional removal epidermis in the past, and except the skin of health and face, also can be applied to massage skin of head by application risk, with blood circulation promoting, stimulate the growth of hair.
Needle body is driven to roll on the skin of human body by roller mount, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thus chafe, promotion ossein hypertrophy, for the natural reaction to epidermis tissue injury, dermal tissue can manufacture the epidermal tissue made new advances, thus reaches the effect of health rejuvenation skin.Using this skin needle roller, can reach without the need to removing epidermal tissue the effect that epidermal tissue is regenerated, and due to epidermis wound small, quickly, the probability being subject to bacteriological infection is also lowered healing stage; In addition, it also can not make epidermal tissue thinning, can repeatedly use.This skin needle roller is easy to use, application risk goes the method for epidermis far below tradition, this skin needle roller effectively can promote the penetration of the medicine, cosmetics etc. of skin, the effect that medicine, cosmetics etc. pass through skin epidermis and skin corium cell is especially remarkable, is the scientific and technological new technique of the carrying method such as medicine, cosmetics.Moreover skin needle roller stimulates the wound self-healing ability of skin corium, thus chafe, promote ossein hypertrophy, for the natural reaction to epidermis tissue injury, dermal tissue can manufacture the epidermal tissue made new advances, and the thickness hypertrophy of skin epidermis can be made to be about percentage eight.And the side effect of skin needle roller technology is extremely low, safe and reliable.
The present invention studies the apparatus of Transdermal absorption targetedly, its use safety, has played effect to greatest extent; Product property is stablized, and can be suitable for suitability for industrialized production; The successful of Transdermal absorption medicine, cosmetics etc., and the scope of application is wide, is therefore easy to apply, can has a tremendous social and economic benefits in the short period of time.
The present invention is that Transdermal absorption provides a kind of new apparatus source, thus to existing Transdermal absorption product systems particularly Drug Percutaneous Absorption product carried out improvement, improved, thus expanded the application of existing Transdermal absorption product.
The present invention is safe and effective, and practicality is comparatively strong, inexpensive, convenient and swift, and its preparation technology is easy, easily operate, easy to use, evident in efficacy, can be used for all kinds of Transdermal absorption.
The present invention studies Transdermal absorption targetedly, has found a kind of new skin needle roller, has expanded new purposes to micropin tourelle, also for Transdermal absorption provides a kind of new rule of origin, has made beyond thought achievement; Meanwhile, use safety of the present invention is handling good, Transdermal absorption successful, play the effect of product to greatest extent, be more suitable for large-scale production and the business application of the industry such as medicine, beauty treatment and industry, can have a tremendous social and economic benefits in the short period of time.
In a word, the active adaption of the present invention job demand of modern beauty, medicine and scientific research field and the needs of human nature service, the present invention is that research and development Transdermal absorption provides new apparatus source, has important value to improving existing Transdermal absorption system.
Accompanying drawing explanation
Accompanying drawing 1 is the schematic diagram of fixed mount of the present invention;
Accompanying drawing 2 is the schematic diagram of needle roller of the present invention;
Accompanying drawing 3 is dynamics and depth curve;
Accompanying drawing 4, experiment effect figure (Franz diffusion cell method) for transdermal administration;
Accompanying drawing 5, experimental result picture for matched group;
Accompanying drawing 6, for experimental group (use micropin group) experimental result picture;
More than in diagram:
1, hands handle; 2, roller mount; 3, needle body; 4, roller bearing; 6, support; 7, roller bearing hole;
9, the junction of handle 1 and support 6.
Detailed description of the invention
The present invention have studied existing Transdermal absorption device, provides a kind of new Transdermal absorption product and structure thereof and purposes, is convenient to improve looks, the safe and effective use of the industry such as medicine.
Skin needle roller introduces existing micropin scroll techniques, and transforms its device, makes it to possess several functions.This apparatus can be applicable to the Transdermal absorption utilization of beauty parlor, hospital, research institution, is conducive to improving transdermal drag delivery system, has good application prospect.
In the present invention, the embodiment of above-described detailed description of the invention and the following stated is all to set forth the present invention better, is not for restriction scope of invention.Below by embodiment, the present invention is described in detail.
The present invention finally needs to be prepared into Transdermal absorption product and applies, and will enumerate embodiment below and be further described.If you have questions, 13386272938 or 15900897066 can be contacted directly with inventor.Several Transdermal absorption product and using method thereof and some experimental study contents is provided by foregoing summary in above-described detailed description of the invention and the following example, but the research contents that the place that should be appreciated that the present invention is not limited to this is listed, should also be appreciated that term as used herein only for describing specific embodiment, and be not limitation of the invention.
Now with regard to apparatus of the present invention, be specifically described below:
Shown in Fig. 1 ~ 2, the present invention relates to a kind of skin needle roller, it comprises roller mount 2, the multiple needle bodies 3 be arranged on the external peripheral surface of described roller mount 2, the diameter of described each needle body 3 is 0.07 ~ 0.35 millimeter, described each needle body 3 to expose in the length of roller mount 2 Outboard Sections be 0.1 ~ 0.3 millimeter.The axial line place of described roller mount 2 offers roller bearing hole 7, can insert roller bearing 4 in roller bearing hole 7, is installed on the frame 6 by roller bearing 4, and roller mount 2 can be rotated around Pivot Point Center line.The rear portion of support 6 has handle 1, operator can hold handle 1 and promote it, support 6 is moved, namely the roller mount 2 be pivotally connected on support 6 rolls on the skin of human body, thus extract rapidly after driving needle body 3 to pierce through the epidermal tissue of skin, needle body 3 pairs of epidermises are made to cause small wound and reach dermal tissue, and for the natural reaction to epidermis tissue injury, namely dermal tissue can manufacture the epidermal tissue made new advances and go to repair these small wounds, thus reaches effect that is young, health skin.
This skin needle roller can be applicable to health and the facial skin of massaging human body, utilizes natural method to stimulate ossein hypertrophy, and can not destroy skin epidermis, thus promote the regeneration function of skin, reach cosmetic result by needle body 3; This skin needle roller also can be applicable to the skin of head of massaging human body, selecting the scalp massage of needle body 3 pairs of human bodies of appropriate diameter, by causing small wound to the epidermal tissue of scalp, the blood circulation of scalp can be promoted, stimulate the growth of hair, to reach aesthetic effect.
In the embodiment that the present invention adopts usually, described multiple needle bodies 3 press 3 ~ 9 column distributions in roller mount 2.In following preferred embodiment, needle body 3 is distributed as 7 row, described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2, namely each individuality often in row needle body 3 arranges along the circumferencial direction of roller mount 2 equally spacedly, this makes the present invention when applying, the epidermal tissue of needle body 3 pairs of skins causes uniform wound, and dermal tissue will produce uniform new epidermal tissue, thus can improve cosmetic result.
Embodiment 1, micropin use dynamics and depth relationship to study
Utilize the device of technical solution of the present invention, particular content is as follows:
Get 8 pieces of in vitro nude mice skin of back, with transformation skin needle roller (500 μm of pins are long) process.Use dynamics is 2.5 respectively, 5,7.5,10,12.5,15,17.5,20N, dynamics electronic balance controls.Dye 2 minutes with methylene blue solution subsequently, clear water washes away dye liquor.After above-mentioned skin dry cotton ball is wiped moisture and residual dye, be cut into the fritter of 1cm × 0.5cm, after tissue immerses OCT liquid subsequently, liquid nitrogen cryogenics is freezing, spends the night, cuts into slices in a cold or frozen state after taking-up, the length of basis of microscopic observation micro hole record.Experimental result (table 1, Fig. 3):
After the transformation of micropin roller, during use, protective cover makes skin smooth, and rolling is easily carried out, and meanwhile, under identical dynamics, micropin thrusts the diversity reduction of skin depth, uses and is easy to operation.
Table 1, micropin use dynamics and depth relationship to study
Effectiveness (the Franz diffusion cell method) research of embodiment 2, transdermal administration
Utilize the device of technical solution of the present invention, particular content is as follows:
Get 2 pieces of nude mice skins, remove subcutaneous tissue, normal saline flushing.Blank group is without micropin process, and experimental group is with transforming the process of micropin roller.Blank group and experimental group skin are fixed on Franz between coyote hole and receiving chamber, and stratum corneum side is to giving coyote hole, and effective infiltrating area is 0.85cm
2.In receiving chamber, add water-alcohol solution (isopropyl alcohol: normal saline=1:1) until with skin close contact (4ml), get rid of bubble, be placed in (37.0 ± 0.5) DEG C water bath with thermostatic control, (200 ± 1) r/min constant speed electromagnetic agitation.0.2g tretinoin emulsifiable paste is applied on Corium Mus horny layer, respectively at 1,2,3,4,5,6,8,10,12h takes out 0.2ml receiving liquid (supplementing rapidly the water-alcohol solution of equivalent after getting liquid), surveys concentration with HPLC.Calculate accumulation infiltration capacity.Lucifuge operates.
By each hours cumulative infiltration capacity of accumulation infiltration capacity formulae discovery.Formula is:
Wherein: Q is accumulation infiltration capacity, receiving liquid drug concentration when Cn is this sub-sampling, V is acceptable solution volume in receiving chamber, and Ci is that S is the i-th sub-sampling amount for the first time to acceptable solution drug concentration during previous sample.
After using transformation micropin roller, drug osmotic amount obviously increases, and about improves 4 times of (see figure 4)s compared with experimental group.
Embodiment 3, skin irritation Journal of Sex Research
Utilize the device of technical solution of the present invention, particular content is as follows:
With the process of repacking micropin roller after nude mice anesthesia, after process, 3d puts to death nude mice, the skin histology getting percutaneous dosing is fixing with the formaldehyde (PBS dilution) of 10%, ethanol dehydration, paraffin embedding, section (5 μm), put on microscope slide, HE dyes, and basis of microscopic observation tissue reaction and inflammatory cell situation, take pictures.Without micropin process is matched group.
HE dyeing course:
1. hematoxylin dye liquor dyeing 5 ~ 15min.
2. running water 3 ~ 5min.
3. 0.5 ~ 1% hydrochloride alcohol solution differentiation several seconds.
4. running water, weak alkaline aqueous solution shows blue 1min.
5. eosin stain dyeing 10min.
6. wash, ethanol serial dehydration, dimethylbenzene is transparent.
7. mounting, put a clean absorbent paper on the table, microscope slide containing material is taken out from dimethylbenzene and is placed on (section one side upwards) on paper, promptly drip natural gum (must not carry out again after dimethylbenzene drying) in the central authorities of section, the right side that pincet clamps coverslip is lightly held with the right hand, tilt to make to hide agent with envelope on the left of it a little to contact, and then put down lentamente, avoid producing bubble.
HE coloration result: matched group (see figure 5) microscope undertissue is normal, uses micropin group (see figure 6) and matched group to organize without significant difference epidermal area and skin corium and does not show inflammatory reaction.
Claims (6)
1. a skin needle roller, is characterized in that, described skin needle roller comprises fixed mount, needle roller two parts;
The support (6) that described fixed mount comprises handle (1), be flexibly connected by junction (9) and handle (1), the roller bearing (4) be connected with support (6),
Described handle (1) and the junction (9) of support (6) adopt the embedded mode of multi-faceted slip or multi-angle movement to carry out activeness to be connected;
Described needle roller comprises roller mount (2), the multiple needle bodies (3) be arranged on the external peripheral surface of described roller mount (2), the roller bearing hole (7) offered at the axial line place of roller mount (2); By roller bearing (4), roller mount (2) is pivotally mounted on support (6);
Described roller mount (2) is a hollow cylinder, and the material used has elasticity;
Described needle body (3) is hollow needle body, is directly fixed on the external peripheral surface of roller mount (2), distributes by multiple row.
2. skin needle roller according to claim 1, is characterized in that, described needle body (3) presses 3 ~ 9 column distributions on the external peripheral surface of roller mount (2), and evenly arranges along the circumferencial direction of roller mount (2).
3. skin needle roller according to claim 1, it is characterized in that, the diameter of described needle body (3) is 0.07 ~ 0.35 millimeter, described each needle body (3) to expose in the length of roller mount (2) Outboard Sections be 0.1 ~ 3 millimeter.
4. the skin needle roller according to any one of claims 1 to 3, is characterized in that, this skin needle roller is used for human body skin administration or cosmetics.
5. skin needle roller according to claim 4, is characterized in that, this skin needle roller is used for human buttock or the direct administration fat-reducing of abdominal part.
6. skin needle roller according to claim 4, is characterized in that, this skin needle roller is used for human body head or face's administration or cosmetics.
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| CN201210545567.8A CN103120826B (en) | 2012-12-14 | 2012-12-14 | A kind of skin needle roller |
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| CN201210545567.8A CN103120826B (en) | 2012-12-14 | 2012-12-14 | A kind of skin needle roller |
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| CN106466505A (en) * | 2015-08-17 | 2017-03-01 | 陈丽娟 | Allow eyebrow renovation process in a short time |
| KR102047477B1 (en) * | 2017-11-21 | 2019-11-21 | (주)디엔컴퍼니 | Roller kit for a roller type skin care device |
| CN108014413A (en) * | 2017-12-18 | 2018-05-11 | 优微（珠海）生物科技有限公司 | Soluble micropin introducing apparatus and its application method |
| CN108498941A (en) * | 2018-04-25 | 2018-09-07 | 武汉德丽福生物科技有限公司 | Micropin Beauty sticking piece with and preparation method thereof |
| TWI702038B (en) * | 2018-09-10 | 2020-08-21 | 微采視像科技股份有限公司 | System for facilitating hair growth |
| CN109966634A (en) * | 2019-02-18 | 2019-07-05 | 郑庾宅 | A kind of cosmetics injection needle roller device |
| CN110152181B (en) * | 2019-05-16 | 2021-08-13 | 苏州市相城区棱峰医疗用品有限公司 | Manufacturing method of tattooing needle head assembly |
| CN111514082A (en) * | 2020-05-14 | 2020-08-11 | 深圳爱思得美容科技有限公司 | Striae gravidarum repair composition and application method thereof |
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| CN201026221Y (en) * | 2007-03-23 | 2008-02-27 | 吴江市云龙医疗器械有限公司 | Skin roller needle |
| CN201231007Y (en) * | 2008-07-23 | 2009-05-06 | 冯来坤 | Simple roller type micro-needle guiding device for beautification |
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| CN101912663A (en) * | 2010-08-18 | 2010-12-15 | 清华大学 | Empty micropin array chip, percutaneous dosing paster, device and manufacture method thereof |
| CN201906354U (en) * | 2010-12-27 | 2011-07-27 | 沈忠忠 | Micro-needle massager |
| CN203169818U (en) * | 2012-12-14 | 2013-09-04 | 上海百华生物科技有限公司 | Skin rolling needle |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101028457B1 (en) * | 2008-08-07 | 2011-04-14 | (주)마이티시스템 | Roller and stamp having detachable minute needle unit |
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|---|---|---|---|---|
| CN201026221Y (en) * | 2007-03-23 | 2008-02-27 | 吴江市云龙医疗器械有限公司 | Skin roller needle |
| CN201231007Y (en) * | 2008-07-23 | 2009-05-06 | 冯来坤 | Simple roller type micro-needle guiding device for beautification |
| CN201399158Y (en) * | 2009-01-20 | 2010-02-10 | 翁春晓 | Transdermal drug-permeating rolling type microneedle |
| CN101912663A (en) * | 2010-08-18 | 2010-12-15 | 清华大学 | Empty micropin array chip, percutaneous dosing paster, device and manufacture method thereof |
| CN201906354U (en) * | 2010-12-27 | 2011-07-27 | 沈忠忠 | Micro-needle massager |
| CN203169818U (en) * | 2012-12-14 | 2013-09-04 | 上海百华生物科技有限公司 | Skin rolling needle |
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