CN203169818U - Skin rolling needle - Google Patents
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- CN203169818U CN203169818U CN 201220697204 CN201220697204U CN203169818U CN 203169818 U CN203169818 U CN 203169818U CN 201220697204 CN201220697204 CN 201220697204 CN 201220697204 U CN201220697204 U CN 201220697204U CN 203169818 U CN203169818 U CN 203169818U
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Abstract
The utility model relates to a pain-free skin rolling needle used for rapidly piercing the skin to feed medicine or cosmetic products. A handle of a fixing frame is movably connected with a supporting frame in a multi-directional sliding or multi-angle moving embedding mode, an idler wheel seat adopts a hollow cylinder body, a skin-piercing and medicine-feeding, skin-piercing absorption and slow release system is modified, the rolling needle can make many microtubules in a short time and enables the medicine, the cosmetic products and the like to directly pierce the epidermal layer or corium layer cells, the wound in the epidermal layer is small and can be healed soon, the possibility of bacterial infection is obviously lowered, the skin will not turn hard or the cell contraction is avoided, the epidermal tissue does not become thin, and the rolling needle can be reused, the skin rolling needle can be further used for massaging the scalp and stimulating the growth of the hair. The skin rolling needle is simple in preparation cost, low in cost, small in side effect, obvious in effect, good in controllability, convenient to use and high in practicability. A user can grasp the rolling needle through simple training. The rolling needle can be directly applied to the daily life, and is more suitable for large-scale production and commercial application in the medical and cosmetic industries, and has obvious effects.
Description
Technical field
This utility model relates to technical fields such as medicine, beauty treatment, specifically relate to a kind ofly give painless doser and structure and the purposes of medicine, cosmetics etc. through skin, more particularly relate to a kind ofly reach that rapid transdermal absorbs or skin-painless needle roller and structure and the purposes of good results such as slow release for transdermal administration or cosmetics.
Background technology
(1) research overview of micropin roller
1, general introduction
21 century, medical circle has faced a new problem at medical domain: how medicine correctly is transported to and need executes the position of controlling, make drug effect maximized performance.The beauty treatment circle also faces same problem, more why be known as the high-tech nanotechnology, raw material is first-class and product such as expensive beauty cream, cosmetic cream after use, effect does not have expectative so obvious, so medical circle is unprecedentedly active about academic research such as percutaneous dosing, Transdermal absorption, slow release in recent years.The gene biological cosmetics can be to the Skin Cell reparation of reforming, but how these compositions is transported to the needed position of skin to cell metabolism generation effect, becomes a difficult problem of gene biological beauty treatment.
Horny layer is the firmest protective layer of skin surface; it also is can not the go directly major obstacle of skin bottom of nutrient in the general cosmetics; medical circle is constantly sought new method, allows the nutrition of beauty treatment aging resistance can penetrate horny layer, directly enters each layer of skin generation effect.Many on the market beauty apparatus all are to see through ultrasound wave intermediate frequency unidirectional current, attempt to strengthen nutrient substance and pass through cuticular ability; How, effect is also not remarkable all the time, and this class technology of life-time service also can cause corse sweat pore.
Along with growth in the living standard, people are increasing to the demand that makes skin rejuvenation, healthization, reach cosmetic result in order to make skin, and method at present commonly used has: grind off epidermis, pickling, laser and remove epidermis etc.The common ground of these methods is: they all are the epidermal tissues of removing skin surface, make the epidermal tissue that the dermal tissue manufacturing of epidermal tissue below makes new advances, thereby reach the effect that makes skin more healthy and smooth.But, use these methods that also there are a lot of drawbacks in skin, the epidermis of human body is that the people resists the extraneous outermost layer barrier that infects, and is removed and in new epidermal tissue's process that growth does not finish as yet in old epidermal tissue, and skin very easily is subjected to the infection of antibacterial and diseases induced; On the other hand, the convalescent period of these Therapeutic Method is long again, is generally the several months; And the skin meeting attenuation that these methods of process were handled is if overtreating also may stay cicatrix, so for most people, these Therapeutic Method can only use once at most.
2, micropin U.S.A definition and principle of moulding
By development of science and technology, laser beautifying is becoming the first-selection treatment of female skin aging, mottle, wrinkle etc. symptom with brand-new attitude.And biological beauty and skin nursing are also just constantly being innovated with completely new concept and technology, and biological beauty is China's popular new technique instantly, particularly micropin beauty treatment, and one of Shou Tui popular new technique especially, its effect is obvious, and is simple to operate,
Now by the approval of vast beauty treatment mechanism, but pain is still the major issue that microneedle therapy faces, and the painless micropin of follow-up release can solve this type of problem effectively, and it is wherein a kind of that micropin U.S.A moulds.
Micropin U.S.A moulds beauty treatment and comes from the U.S., claims micropin mesoderm beauty curing (mesotherapy) again, or claims microneedle therapy (to be called for short: MTS).
It is at the skin micropin that rolls that micropin U.S.A moulds, use the micropin roller to stimulate human body skin, micropin can produce between the skin aspect and surpass 200 in very short time, 000 fine conveyance conduit, make various active compositions such as cell growth peptide gene active component and multi-nutrition element directly effectively infiltrate deep skin, the product assimilation effect is more than 4000 times of common spread product; Be equipped with wrinkle removal, speckle dispelling, the products such as striae gravidarum, scar eliminating of whitening, repair, dispel, can efficiently repair rapidly, active cell, promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination cicatrix, mottle, smooth wrinkle, subtract that light wrinkle, treatment cicatrix, anti-acne, anti-acne seal and striae gravidarum, skin are whitened, subtracted the light color speckle, improve eye wrinkle-removing, black eye, tighten up and promote ideal effect such as skin of face tissue thereby reach.
The principle that micropin U.S.A moulds is a kind of therapy of improving looks at the skin mesoderm, this therapy is skin care activity composition or nutritional labeling to be input to mesoderm by certain special installation (that is: instrument is moulded by U.S.A) play a role, and this U.S.A to mould instrument be exactly micropin roller (B.N.M meso Roller or Meso Roller, sometimes also be called for short: micropin) or U.S.A mould rifle (Meso Gun), different equipment has different action principles: the micropin roller is to utilize that many little pins (small syringe needle) penetrate horny layer on the roller, chafe, micropin can be made and surpass millions of ultra micro tubules in very short time, be equipped with wrinkle removal, whiten, repair, the striae gravidarum of dispelling, specially good effect products such as scar eliminating, make active component effectively infiltrate skin and the importing of aidant component subtracts light wrinkle thereby reach, treatment cicatrix and striae gravidarum, skin is whitened, subtract the light color speckle, improve eye wrinkle-removing and black eye, tighten up and promote ideal effects such as skin of face tissue; Simultaneously micropin stimulates skin corium, and percutaneous self-healing ability promotes the ossein hypertrophy, can make the thickness hypertrophy of skin epidermis about 8%, can the match in excellence or beauty plastic operation of laser and filled type of its effect.And the microsyringe that rifle is automatization is moulded by U.S.A, directly composition is expelled to subcutaneous.These two kinds of equipment can be selected according to the needs of self, and the micropin roller is safe, and is easy to use, be widely used, and U.S.A mould rifle and mainly certain advantage arranged aspect partial-depth wrinkle and the local weight reducing fat melting tackling.
Micropin U.S.A mould be utilize a kind of deep layer be used for skin is carried out aesthetic nursing, compared with superficiality nursing in the past, this treatment can reach effect more completely, but also can guarantee can not cause extra infringement to skin, so be a kind of desirable beauty treatment means.
Micropin U.S.A moulds and can open towards the passage of skin basal layer moment, somatomedin is transported to the skin bottom endlessly: can activate self cell regeneration, strengthen self synthetic and secretion function, endogenous replenishing collagen and elastic fibers, remove interior free yl, reduce biological oxidation and aging; Can directly act on basal layer melanin, suppress melanin and generate, spot fading is accelerated metabolite and is transported, and removes the free radical that causes human senility, thus delaying skin aging, and that skin and muscles are fair is smooth in order, fine and smooth as silk; Wrinkle removal simultaneously skin becomes delicate smooth and compacts beautifully, promotes division and the growth of Skin Cell strongly; Irritate the synthetic and secretion of hyaluronic acid, collagen protein and glycoprotein etc., make the wrinkle of skin Lock-out, skin recovers gloss and elasticity, is fit to the dark person of local wrinkle.In the time of the micropin chafe, can also stimulate the hypertrophy of skin corium collagen and fibroblast, not only small wound healing is rapid, and preventing from scar.
Micropin U.S.A moulds and can effectively improve face skin problems such as sunburn, chloasma, freckle, plumbous mercurialism, facial pigmentation skewness, the colour of skin are dark and gloomy, the coarse tarnish of skin; At acne pothole skin, the contained biology acne pothole skin-active composition of dispelling directly acts on the fibrocyte of deep skin fracture, promotes collagen protein synthesis, regenerate fibrous tissue, thereby arrive the reconstruction of deep layer reticular fiber structure, calm down the acne pothole, reappear smooth fine and smooth skin.
3, the characteristic of micropin beauty treatment
Effect and the characteristics of micropin beauty treatment:
1. utilize the normal healing ability of wound, can not make the skin hardening or cause that Skin Cell shrinks.
2. micropin can be made a large amount of microtubules, makes active component effectively infiltrate skin (only need to use five minutes, just can produce above 200,000 micropores).
3. side effect is extremely low.
4. use behind the microneedle theraphy nursing simple and easy, can carry out general outdoor activities, comprise and getting sun.
Advantage is moulded by micropin U.S.A:
Naturality: do not influence histrionic muscles and face nerve, expression natural shape harmony after the reduce wrinkle.
Safety: with the human body homology, do not have obviously rejection and side effect, leave no trace after the treatment, cicatrix, safe and reliable.
Persistency: promote human body cell continuous release collagen protein, elastin laminin, curative effect is permanent.
Simplicity: with doing with walking, noinvasive is painless, does not influence work and life, is also referred to as " lunch break erugation ".
High efficiency: dispel true property wrinkle and reach more than 95%, reverse aging, young 5～10 years old.
The problem that the micropin roller solves:
1. subtract light wrinkle, bring out the ossein hypertrophy, treatment areolar tissue, skin thickness problem, treatment cicatrix and striae gravidarum;
2. skin is whitened, and subtracts the light color speckle, improves eye wrinkle-removing, black eye, stimulates the ossein hypertrophy, tightens up and promote the skin of face tissue;
3. administer alopecia, care and household etc. and effectively carry nutrient.
Now a lot of cosmetics all have in various degree damage to skin, concerning using such personage that likes to be beautiful, be undoubtedly a kind of injury, so they are more careful when selecting cosmetics for use, and the harm that micropin U.S.A moulds almost is non-existent, is a kind of more safe and reliable beauty method that skin is not had substantially damage.
It is to mould instrument by U.S.A the required nutrient of skin is imported to reach cosmetic result after making skin fully absorb in the skin that needs to change that micropin U.S.A moulds, it is different from other beauty method, be need not operate on, need not take medicine, accurate effective beauty method, it is a kind of point-to-point beauty method: the integrity that does not destroy skin texture, set up a large amount of skin microtubules, the transport substrate cosmetics; Progressively remove deep skin toxin and refuse; The chafe self-healing ability promotes skin metabolism, keeps skin elasticity and handsome U.S.; Active cell, repair damaged tissues, participate in cellular metabolism directly, reach wrinkle removing, promote, whiten, antidotal effect; Utilize the normal healing ability of wound, induce nutrition and the collagen growth of skin self; Safe and reliable having no side effect.
The harm of moulding of micropin U.S.A almost is non-existent thus, by time weak point, instant effect, the no cicatrix of its beauty treatment, the crowd of various skin problem is suitable for.
The rise that micropin U.S.A moulds has solved the century difficult problem on the world of medicine, beauty treatment circle.Use B.N.M meso Roller chafe, make a large amount of microtubules, make active component effectively infiltrate skin.Trickle rolling acupuncture can also stimulate the hypertrophy of skin corium collagen protein and fibroblast simultaneously.This kind Wicresoft is to use also littler than 30G fine needle " micropin " carry out the aculea action, not only " Wicresoft hinders " healing is rapid, and preventing from scar.In other words, directly cell is grown peptide gene active component and multi-nutrition element etc. give the skin cell rapid osmotic of different depth via very tiny pin hole.These tiny Wicresofts can't cause the excessive wound of skin and burden, in reparation period, can also activating cell, and promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination pox scar color element; + 6 also can allow Skin Cell see through microtubule directly absorbs the gene activity composition that skin needs, and assimilation effect approaches absolutely, therefore can give different prescriptions at demands of individuals, and new skin is lived again, and thoroughly improves skin matter.
4, micropin roller
(1) textual investigation
The micropin roller is that used instrument is moulded by micropin U.S.A.Micropin, the needle set name, the appearance of micropin one word can be found at Huangdi's Internal Classics, and it refers to fine fine little needle sets such as acupuncture needle." the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " in the Huangdi's Internal Classics: " desiring to transfer its vim and vigour with logical its passages through which vital energy circulates of micropin ... ", nowadays, micropin just extensively applies in the beauty treatment.
The justice of micropin has two:
1. small pin, little pin." element is asked the treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it controls suitable micropin." the Wang Bingci notes: " little, also tiny.Tiny pin, pulse-taking decline and contain also." " the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint ": " wanting of little pin easily oldly and difficult gone into." " class is through 19 volume acupuncture classes one ": " little pin, the i.e. meaning of micropin above.”
2. nine kinds of needles." element is asked the treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it controls suitable micropin.So the nine kinds of needles person also comes from south." " element is asked knowledge ": " [nine kinds of needles], high cloud: ' " Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles opinion " Yellow Emperor, a legendary ruler desire with logical its passages through which vital energy circulates of micropin.Micropin, little pin also.The little pin of qi uncle opinion and and in nine kinds of needles, so the person that says the nine kinds of needles also comes from south.' letter press: " the nine kinds of needles twelve source acupoint ": ' Supreme Being asks useless stone needle, desires with logical its passages through which vital energy circulates of micropin.And qi uncle answers to start from one finally nine.' then micropin namely be nine kinds of needles, for stone needle, outside the non-nine kinds of needles micropin is arranged.Will cloud: ' micropin person.Its cutting edge of a knife or a sword is fine.The pin of shallow puncture also.' fear non-ly be.”
The micropin roller is French medical expert Horst doctor's invention the earliest, adopts Switzerland's high-quality medical treatment rustless steel, continues to use the casting method of German craftsman invention in 1896, forms in the subzero 60 supercool freeze techniques manufacturings of spending Celsius.So, the based on very high purity of micropin, very hard.
Present a micropin roller is based on the Anti-slip handle of bionics design, the pure moulding of streamlined fashion, and run-bake-needle fault not, the needle point slyness is sharp, is the latest generation micropin roller that takes the lead industry at present.
(2) basic structure and specification
Have a lot of diameters micropin the same with spacing on the micropin roller, different needle roller then spacing and the diameter of its micropin understands that some is different, be to select the micropin specification that is fit to according to skin conditions, and generally be that pin length is the micropin of 0.3～1.25mm.Long micropin is more deep to the stimulation of skin, and higher relatively to treatment personnel specification requirement, treating employed micropin is not that the longer the better yet; If be not suitable for patient's skin thickness, that effect can only be reciprocal, because it is by micropin thorn expelling pathogenic factors from the exterior skin that the principle that works is moulded by micropin U.S.A, import to be fit to the essence of relevant skin problem or medicine etc. again, allow essence or medicine etc. directly be penetrated within the epidermis like this, improve and repair cortical tissue and cell.
So the treatment of the saturating property of such thorn need allow the doctors and nurses of specialty operate in medical cosmetology mechanism, a people one pin, strict sterilization is not reused, and could guarantee the safety for the treatment of.
Micropin specification (mm i.e. millimeter, is the length of pointer, is not the width of roller):
1. 0.25mm: generally be used for going red blood streak, cell more living;
2. 0.5mm: generally be used for wrinkle removal, whiten, speckle dispelling, receipts fine, soft fur hole;
3. 1.0mm: generally be used for recessed scar, pox hole, cicatrix reparation;
4. 1.5mm: generally be used for going striae gravidarum.
(3) relevant product
The product that report is arranged at present, for example Mesomed micropin rod is to make with plastic cement, and volume is light and handy, and about 200 very tiny medical titanium syringe needles above distribute.
A kind of commercially available micropin roller product section details is as follows:
Weight: 55 grams (comprising packing)
Package size: 16cm * 3.5cm * 5.5cm
Color: white orange or transparent orange
Micropin material: medical use rustless steel (silver)
Micropin is arranged: yi word pattern is in line
Ai disappears: EQ Gas, the Gamma Ai ray that disappears, ethanol, the UHT high temperature Ai that disappears
Namely abandon: be (Ai unless disappear again)
Pin is long to be selected: 0.2mm/0.25mm/0.3mm/0.5mm/0.75mm/1.0mm/1.5mm/2.0mm/2.5mm/ 3.0mmOEM/ODM selects: can
Environmental conservation: identify the greening material
Specification: ISO11137, CE, FDA
Micropin quantity is 540 on the micropin roller, and pain reduces by half than common micropin; The kermesinus roller, bright pearl white handle.
The solid roller design of this product guarantees to use safety.
The solid roller design of Britain's micropin is derived from the requirement of FDA and CE blueprint, and has adopted seamless technology to produce and guaranteed can not grow at roller in sterilization back antibacterial, but more stops to appoint the disaster of bacterial invasion.Occurred some low-cost hollow roller micropins of being convenient to produce recently on the market, hollow roller can lower the trouble of much installing undoubtedly, but this design but has big extremely health to detect problem.For example nursing in the course for the treatment of, coating the middle part that the fine blood streak remaining on facial skin care item or the micropin also can enter roller through the joint close on the hollow roller because of carelessness.Ai does perfectly inadequately if disappear, and the micropin roller that this FDA of not meeting or CE require is definitely might make skin be subjected to the crisis of bacterial invasion and leave behind nonvolatil injury.
The whole handle of micropin requires through meeting ergonomic designs, and this design can reduce the strain on the finger effectively and the grip that increases between finger tip and the handle has avoided unclamping because of carelessness the injury that handle can be made (for example the barefoot hands is slippery absent-mindedly).The material that micropin uses can bear high temperature, heat-resisting not modification.
Have a kind of product of painless aculea rolling instrument to report: the life-span of high-quality micropin roller and effect are that the grinding state by the material of micropin itself and needle point determines.192 micropins of the painless micropin roller of this product are to be made by Korea S's high density medical stainless steel, in conjunction with international advanced pin technology processed, draw point is hard, and it is atomic thin, so can not cause client's pain when thrusting skin, the common needle roller of the above painless needle roller contrast same specification of 0.5mm could make client's pain reduce more than 50% 0.25mm it is 100% painless that the needle roller of length can reach!
Also have a kind of product to report: the structure of skin needle roller is composed as follows: needle body adopts 0Cr19Ni9 or other austenite stainless steel wires select for use among the GB/T4240 " stainless steel silk ", through sharpening, injection moulding, inlay, operation manufacturings such as assembling, heat-sealing form.It is 0.2mm, 0.3mm, 0.5mm, 1.0mm, 1.5mm, 2.0mm that this product exposes the outer needle body length of surveying of roller sheet; The needle body diameter is 0.16mm, 0.18mm, 0.20mm, 0.22mm, 0.25mm, 0.30mm; The technical parameter of this product is: needle body hardness 〉=460HV, the numerical value of 0.2kg surface roughness Ra are not more than 0.5 μ m.The design of needle roller spreads all over intensive, and pin and pin have only 0.3mm apart, can reach the optimal healing effect to wound.
(4) relevant patent application
Patent of invention " a kind of miniature needle roller " (application number: 200810089036 is arranged, the applying date: 2008-04-16) claim: a kind of miniature needle roller, comprise a plurality of fine needle substrates 10, cylinder substrate 20 and pair of discs 30, described fine needle substrate 10 is by forming by a plurality of microneedle 11 of certain distance configuration, and there is jut 12 lower end, both sides of fine needle substrate 10; The both sides of described cylinder substrate 20 are provided with patchhole 21, and the jut 12 of lower end, fine needle substrate 10 both sides can directly be inserted in this patchhole 21; Described disk 30 comprises the fixedly insertion section 31 of annular.Described whole cylinder substrate 20 and fine needle substrate 10 in conjunction with after, both sides in conjunction with protuberance 13 form an integral body in conjunction with fixed part 22, be inserted in the fixedly insertion section 31 of above-mentioned disk 30, fine needle substrate 10 and cylinder substrate 20 break away from when preventing from rotating.After adopting this utility model, its simple and convenient assembly saves time and laborsaving, reaches the effect that fraction defective is minimum, productivity ratio is the highest.In addition, the effect that fine needle substrate and cylinder substrate break away from mutually in the time of can also reaching pre-anti-rotation.
Utility model patent " skin needle roller " (application number: 200720035626.1 is arranged, the applying date: 2007.03.23) claim: a kind of skin needle roller, it comprises roller mount, be arranged at a plurality of needle bodies on the external peripheral surface of described roller mount, the diameter of described each needle body is 0.07～0.35 millimeter, and the length of exposing at the roller mount Outboard Sections of described each needle body is 0.1～3 millimeter.Driving needle body by roller mount rolls at the skin of human body, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thereby chafe, promotion ossein hypertrophy, for the natural reaction to the epidermis tissue injury, dermal tissue can be made the epidermal tissue that makes new advances, thereby reaches the effect of healthization rejuvenation skin.Use this skin needle roller, need not to remove epidermal tissue and can reach the effect that makes epidermal tissue's regeneration, and because the epidermis wound is small, healing stage is very fast, the probability that is subjected to bacterial infection also is lowered; In addition, it can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, and application risk goes the method for epidermis far below tradition.
(5) up-to-date basic technology progress
" Science and Technology Daily " December in 2011 reported on the 23rd: the engineer develops painless silk micropin, can accurately control drug release.Organize 22 (Beijing time) of net December, the bioengineer of engineering college of U.S. Tufts University to develop a kind of painless silk microneedle device according to U.S.'s physicist, can in long-time, drug slow be discharged, need not the unnecessary medicine of cold preservation.This micropin has biocompatibility and biological degradability concurrently, can make under normal temperature and pressure, can load the biochemical drug of easily being damaged and keep its activity.Relevant paper is published on " advanced function material " website.
Demonstrator Trials shows that new-type silk micropin can be sent macromole, catalator medicine, horseradish peroxidase with controllable speed, also keeps the biological activity of medicine simultaneously; The silk micropin that loads tetracycline can also suppress the growth of staphylococcus aureus, shows this micropin in delivering therapeutic agents, also has the potential value of prevention local infection.
Although some medicine can directly be swallowed, some can't bear the gastrointestinal digest and decompose.Hypodermic mode is relatively more painful, can not slowly discharge medicine.Have only small-molecule drug seldom to enter in the body with the mode that sticks.Silk micropin 1 micron size only can penetrate upper strata skin and can not touch nerve, is a kind of new painless type mechanisms for drug release.But have a lot of difficult problems to hinder the development of this technology at present, as the vulnerability of biological product make medicine in manufacture process loss of activity, can not accurately control drug release or put infection that too much, the small skin penetration of medicine brings etc.
At these problems, research worker has been developed new fabrication schedule, and process comprises pressure, temperature and water treatment etc.They are formed from aluminium the micropin master mold, line up 500 microns high, and needle type radius is less than 10 microns array; (be called for short: PDMS) be cast in and form die on the master mold with resilient dimethione; Again the silk protein solution that medicine is housed is injected die.After the silk drying, again the silk micropin that comprises medicine is taken off further processing.Post processing comprises with steam limbers up it, by the various processing of temperature, machinery and electronics, makes it have corresponding diffusibility and drug releasing rate again.
Research worker is represented, regulates the post-treatment condition of fibroin, as changing drying time, mainly is its secondary structure of control, can accurately control drug releasing rate.Through discharging the dynamic model test, drug releasing rate can reduce by 5.6 times, and this has solved a drug release difficult problem for a long time, can also be used in other biological storage aspect.
Paper co-author, Ta Fusi biomedical engineering chairman David Kapp orchid point out that also this micropin is very flexible, can enlarge or dwindle, transport or store to need not cold preservation, management get up just as plaster or binder easy.
The non-fresh thing of microneedle therapy.Ancestor " the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " just has cloud: " desiring to transfer its vim and vigour with logical its passages through which vital energy circulates of micropin ... ".Although the size of those micropins cannot compare the principle of from outward appearance to inner essence curing the sickness to save the patient, broadly similar really with present pinpoint array less than 10 microns radiuses.As for the main innovate point of Tufts University, show that in fact they select silk and organosilicon to make base material, utilize material behavior to realize slow release, controlled release.Heal to become in the maturation when microneedle therapy, that try the water can not be the patient of hanging down, but large quantities of desire is for pleasing the woman that own person holds.
(2) research overview of needle roller
1, general introduction
The product somewhat similar with micropin has the device that contains needle roller, is a kind of be used to the particularly machinery of the Suzhou embroidery skill of handling needles of embroidering.
2, needle roller
Needle roller (needle roller) refers to that the length-to-diameter rate is greater than 2.5 small diameter cylinders roller, belonging to the rolling bearing (three grades of subjects) in the mechanical machine components of one-level subject (secondary subject) of application branch of learning, is a kind of in the sewing of one of Suzhou embroidery skill of handling needles bar.Palpus, the eyebrow of the suitable embroidered beast of this needle roller, personage's hair, the pleat stricture of vagina of clothes and thin narrow pattern line kind etc.The tight Jing'an of two lines becomes striped, and the lines turnover is more flexible.It is all relatively more appropriate to embroider straight line, curve.
The embroidery step: fall after rising before the grain pattern lines, the pin pin is tightly secret, and lines length is same, about an about city divides.The turning point can be slightly short, so that turnover.After embroidering first pin, second pin that should fall at first pin, 1/2nd places is ensconced under the last pin needle tracking.The 3rd pin drops on 1/2nd places of second pin, tightly presses the end of the first needlework bar, by that analogy.
Needle bearing (needle roller bearing): referring to that rolling element is the radial bearing of needle roller, is the roller bearing of band cylindrical roller, and its diameter relatively, roller are not only carefully but also long.This roller is called needle roller.Although have less cross section, bearing still has higher load-bearing ability, therefore, is specially adapted to the restricted occasion of radial space.
The needle roller contoured surface shrinks a little at the proximal end face place.Needle roller and Race Line Contact correction result can avoid producing damaging edge stress.The supporting rollern needle bearing is the heavy wall outer ring, quenches through the high nitrogen of high temperature, and the roller of high-accuracy sorting utilizes the wire contact by the lip-guided of high rigidity outer ring, and roller can directly easily rotate on raceway, and can bear huge load.Be to remove stress, the cambered surface design is adopted in the outer ring of support roller, all size models such as curving roll is with single, double sealing ring, is not with sealing ring, band sealing ring.Band sealing ring storage grease space is big, provide the lithium saponify permanence lubricated, and prolongs at interval lubricated.The sealing ring material is band skeleton acrylonitrile-butadiene rubber or ST12, and its operating temperature scope is-30 ℃ to+100 ℃ or-30 ℃ to+180 ℃.The curving roll of closely packed formula can bear heavier extremely strong load and high performance operation.RSTO does not have rib in the outer ring, no inner ring supporting rollern.
The characteristics of needle bearing and purposes:
Needle bearing is equipped with thin and long roller, and (roller length is 3～10 times of diameter, diameter generally is not more than 5mm), so the radial structure compactness, when its internal diameter size is identical with the other types bearing with load-carrying ability, the external diameter minimum is specially adapted to the radially restricted supporting result of installation dimension.According to the use occasion difference, can select bearing or needle roller and the retainer assembly of no inner ring for use, the journal surface that match with bearing this moment and shell aperture surface are directly as the inside and outside rolling surface of bearing, for guaranteeing load-carrying ability and behavior in service and having the lasso bearing identical, the hardness of axle or shell aperture raceway face, machining accuracy and surface quality should be similar with the raceway of bearing ring.This kind bearing only can bear radial load.
The type of needle bearing:
The bearing that can be used for common engineering, as: open type drawn cup needle roller bearing, closed drawn cup needle roller bearing, tool inner ring needle bearing and the inner ring needle bearing/no inner ring of not having do not have the retainer needle bearing, retainer is arranged and do not have retainer and fill needle bearing.
Though above-mentioned needle roller device is different with technical field of the present utility model, with beauty treatment skin needle roller described in the utility model the place that can be worth reference and reference is arranged still also on the product manufacturing technology.
Therefore, seek novel, Transdermal absorption better effects if, use that the skin-painless needle roller is still imperative more easily.
By literature search etc., up to the present, still find no the skin-painless needle roller product of renewal and the report of aspects such as structure and purposes thereof.
Summary of the invention
The technical problem of the required solution of this utility model is to disclose a kind of a kind of skin-painless needle roller and structure and purposes that reaches good results such as Transdermal absorption, slow release for transdermal administration or cosmetics, namely this device has quick administration, easy to use, new role such as infection chance is few, can be used in technical fields such as medicine, beauty treatment, to overcome the above-mentioned defective that prior art exists.
That is to say, this utility model is at the deficiencies in the prior art, by practical studies and theory studies such as zoopery and clinical trials, one of purpose is intended to provide a kind of new doser, and a kind of safer, more convenient, easier skin-painless needle roller of controlling namely is provided; Two of the purpose of this utility model provides a kind of purposes of new micropin tourelle.
Skin needle roller described in the utility model (also claims: skin needle roller device, micropin roller devices sometimes, skin micropin roller devices, micropin tourelle, skin micropin tourelle, needle roller device etc.) refer in the technical fields such as medicine, beauty treatment, a kind ofly be directly used in product quick, painless Transdermal absorption; Preferably be directly used in the product of beauty industry, i.e. the U.S. molding product of a kind of new micropin.
(1) technical conceive
Exploring and improve existing micropin technology and supporting skin needle roller is a urgent task of Chinese medical, beauty industry safety, quick administration or cosmetics, particularly to study and improve fast medicine, cosmetics correctly to be transported to and to execute the subcutaneous location of controlling, effect is maximized, be the forward position of academic researchs such as percutaneous dosing, Transdermal absorption, slow release, can solve a difficult problem of biological beauty.
Horny layer is the firmest protective layer of skin surface; it also is can not the go directly major obstacle of skin bottom of effective ingredient in general medicine, the cosmetics etc.; medical circle, beauty culture are all constantly being sought new method; allow relevant effective ingredient can penetrate horny layer, directly enter each layer of skin generation effect.
In actual use, the designer finds existing skin-painless needle roller, general skin skin needle roller for example, when particularly facial skin uses in use, when handling skin, operation is had relatively high expectations: the one, when dragging skin skin needle roller back and forth, skin creases easily, if excessive velocities causes hemorrhage or pain, need take moderate speed; The 2nd, need the skin surface of processing possible uneven, particularly in face, the angle and direction that in the process that drags, often needs conversion at any time to drag, the uncontrollability of increase operation has improved the requirement of operating; The 3rd, the needle body length of same skin skin needle roller is fixed, to same client's different parts or different demand, often need to use two or more skin skin needle rollers, increase client's cost, use different skin skin needle rollers in turn, also increased the chance that may cause infection; The 4th, need to handle earlier skin, after forming a large amount of trickle ducts, could administration or cosmetics etc., be difficult to carry out simultaneously, operate untimely or other are improper, increased the chance that may cause infection.
Therefore, for reducing infection chance, improving safety, increase control convenient, convenient more people use, and particularly are convenient to client oneself and directly use this skin needle roller, according to this idea and thinking, the designer has consulted a large amount of data, compare existing various product, experimentation and analysis and theory study by repeatedly successfully obtain result of study and the application product of expecting.
This utility model mainly be at utility model patent " skin needle roller " (application number: 200720035626.1, the applying date: 2007.03.23) carry out improvedly, and its purposes expanded to a plurality of technical fields such as medicine, beauty treatment.
The woman's beauty treatment of improving looks particularly is the focus that the whole world all is concerned about, rapid transdermal administration, Transdermal absorption, slow release etc. also are the focuses that pharmaceuticals industry generally is concerned about.Heal to become in the maturation when microneedle therapy, more large quantities of desires will be arranged for pleasing the woman that own person holds.As can large tracts of land promoting the use of this utility model skin needle roller, this technology will have remarkable social benefit, economic benefit.
(2) skin needle roller and uses thereof
This utility model has carried out many-sided test and research exploration to the skin needle roller at beautifying skin, rapid transdermal administration, Transdermal absorption, slow release etc.
The technical solution of the utility model is as follows:
A kind of skin needle roller, it comprises fixed mount and needle roller two parts:
Described fixed mount comprises handle 1, sees Fig. 1 by junction 9 and the support 6 of handle 1 flexible connection, the roller bearing 4(that is connected with support 6);
But the described handle 1 preferred embedded mode that adopts multi-faceted slip or multi-angle to move carries out activeness with support 6 and is connected, and namely described handle 1 and the junction 9 of support 6 are that embedded mode that the multi-faceted slip of employing or multi-angle move carries out activeness and is connected;
Described handle (1) is that the embedded mode that adopts multi-faceted slip or multi-angle to move carries out the connection that activeness is connected with the junction (9) of support (6);
Described needle roller comprises roller mount 2, be arranged at a plurality of needle bodies 3 on the external peripheral surface of roller mount 2, the roller bearing hole of offering at the axial line place of roller mount 27; By roller bearing 4 with roller mount 2 pivotal mounting on support 6, be convenient to control roller mount 2 in the human body skin (see figure 2) of rolling by the mode that pushes away or draw;
Described roller mount 2 is hollow cylinders, preferred cylinder; Needle body 3 is hollow needle body; And each row needle body 3 is directly fixed on the roller mount 2, presses multiple row at the external peripheral surface of roller mount 2 and distributes, and preferably by 3～9 column distributions, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2; Roller mount 2 employed materials have elasticity, and when dragging this utility model device, under the pressure that drags, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3;
The diameter of described each needle body 3 is 0.07～0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1～3 millimeter; Drive needle body by roller mount 2 and roll at the skin of human body, needle body can pierce through the epidermal tissue of skin, and it is caused small wound, reaches dermal tissue then.
This utility model is mainly used in the percutaneous drug delivery at positions such as the health, face of human body or cosmetics etc., can be used for the direct administration of human buttock or skin of abdomen to reach the effect of quick weight-lossing, is preferred for the percutaneous drug delivery of human face or cosmetics etc.; And except the skin of health and face, also this skin needle roller can be applied to massage skin of head, with blood circulation promoting, stimulate the growth of hair.
Existing skin needle roller (application number: 200720035626.1, the applying date: 2007.03.23) comprise fixed mount and needle roller two parts, described fixed mount comprises handle 1, roller bearing 4, support 6; Described needle roller comprises roller mount 2, needle body 3, roller bearing hole 7; Each modular construction and basic annexation are as follows:
Described handle 1 is fixedlyed connected with support 6, and support 6 is connected with roller bearing 4; Described roller mount 2 comprises a plurality of wheel sheets 5 in the form of annular discs, described a plurality of sheet 5 of taking turns is arranged in order and connects in the end, described a plurality of needle body 3 distributes by multiple row at the external peripheral surface of roller mount 2, and each row needle body 3 is fixedly clamped respectively between adjacent wheel sheet 5; Axial line place in described roller mount 2 offers roller bearing hole 7, by roller bearing 4 with roller mount 2 pivotal mounting on support 6, be convenient to control roller mount 2 by the mode that pushes away or draw and roll at human body skin;
The diameter of described each needle body 3 is 0.07～0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1～3 millimeter;
Preferred mode is: described a plurality of needle bodies 3 are pressed 3～9 column distributions usually on roller mount 2, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2.
This utility model improves following two aspects:
The one, improved the connected mode (see figure 1) of handle 1 and support 6, namely handle 1 adopts revocable movable connection method with the junction 9 of support 6, but namely handle 1 adopts multi-faceted slip or multi-angle to move embedded mode to carry out activeness with support 6 and be connected; This improvement has solved and has been difficult to the problem that random conversion drags angle and direction, has increased handlingly, is easier to use;
The 2nd, improve roller mount 2 and needle body 3(and see Fig. 2), described roller mount 2 is hollow cylinders, no longer comprises a plurality of wheel sheets 5 in the form of annular discs, preferred cylinder; Needle body 3 by solid change into hollow; And each row needle body 3 is fixedly clamped respectively and changes each row needle body 3 into be directly fixed on the roller mount 2 between adjacent wheel sheet 5; Roller mount 2 employed materials have elasticity, and when dragging this utility model device, under the pressure that drags, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3.Adopt disposable occupation mode, the problem of administration simultaneously or cosmetics had reduced operation sequence and infection chance when this improvement just can solve processing skin, was more convenient for using, and was easy to promote.
Improve further elaborating as can be seen of introduction and technical scheme from above population structure, the micropin tourelle is a kind of novel device that is used for purposes such as beauty treatment, administration, can be used in client or patient's aspect such as beautifying skin, percutaneous drug delivery, not only simple in structure, easy operation, usage charges are low, and firmly symmetry is stable, but the dragging speed self regulation has reduced the chance that infects, use safelyr, having improved can be handling.
(3) technology speciality
This utility model provides a kind of new beautifying skin, the apparatus of percutaneous drug delivery for medical treatment, beauty industry, thereby improve and improve medicine, cosmetics correctly being transported to systems such as to execute the subcutaneous location of controlling, particularly percutaneous dosing, Transdermal absorption, slow release.This utility model is safe and effective, and practicality is stronger, and its preparation technology is simple, and is inexpensive, simple to operate, convenient and swift, can grasp through simple training, can be directly used in the daily life.
The utility model has the advantages that: the needle roller therapy utilizes the normal healing ability of skin to finish, and can not make the skin hardening or cause the contraction of Skin Cell, and needle roller can be made a large amount of microtubules, is beneficial to directly infiltrate medicine, nutritional solution etc. subcutaneous.Use needle roller treatment back nursing simple and easy, can carry out general outdoor activities, comprise and getting sun.In addition, this skin needle roller can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, because the epidermis wound is small, healing stage is very fast, the probability that is subjected to bacterial infection also is lowered, application risk is far below the method for in the past traditional removal epidermis, and except the skin of health and face, also this skin needle roller can be applied to massage skin of head, with blood circulation promoting, stimulate the growth of hair.
Driving needle body by roller mount rolls at the skin of human body, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thereby chafe, promotion ossein hypertrophy, for the natural reaction to the epidermis tissue injury, dermal tissue can be made the epidermal tissue that makes new advances, thereby reaches the effect of healthization rejuvenation skin.Use this skin needle roller, need not to remove epidermal tissue and can reach the effect that makes epidermal tissue's regeneration, and because the epidermis wound is small, healing stage is very fast, the probability that is subjected to bacterial infection also is lowered; In addition, it can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, application risk goes the method for epidermis far below tradition, this skin needle roller can effectively promote the penetration of medicine, cosmetics of skin etc., the effect that medicine, cosmetics etc. pass through skin epidermis and skin corium cell is especially remarkable, is the scientific and technological new technique of carrying methods such as medicine, cosmetics.Moreover the skin needle roller stimulates the wound self-healing ability of skin corium, thereby chafe promotes the ossein hypertrophy, and for the natural reaction to the epidermis tissue injury, dermal tissue can be made the epidermal tissue that makes new advances, and can make the about percentage eight of thickness hypertrophy of skin epidermis.And the side effect of skin needle roller technology is extremely low, and is safe and reliable.
This utility model is studied the apparatus of Transdermal absorption targetedly, and it uses safety, has brought into play effect to greatest extent; Product property is stable, can be suitable for suitability for industrialized production; The effect of Transdermal absorption medicine, cosmetics etc. is obvious, and the scope of application is wide, therefore is easy to apply, and can have a tremendous social and economic benefits in the short period of time.
This utility model provides a kind of new apparatus source for Transdermal absorption, thus to existing Transdermal absorption product systems particularly drug transdermal absorb product and carried out improvement, improved, thereby the application of having expanded existing Transdermal absorption product.
This utility model is safe and effective, and practicality is stronger, and is inexpensive, convenient and swift, and easy, the easy operation of its preparation technology is easy to use, evident in efficacy, can be used for all kinds of Transdermal absorption.
This utility model is studied Transdermal absorption targetedly, has found a kind of new skin needle roller, and the micropin tourelle has been expanded new purposes, also for Transdermal absorption provides a kind of new rule of origin, has made beyond thought achievement; Simultaneously, this utility model uses safety, and is handling good, the Transdermal absorption effect is obvious, brought into play the effect of product to greatest extent, be more suitable for large-scale production and commercial application of industry such as medicine, beauty treatment and industry, can have a tremendous social and economic benefits in the short period of time.
In a word, this utility model active adaption the job demand of modern beauty, medicine and scientific research field and the needs of human nature service, this utility model has important value for the research and development Transdermal absorption provides new apparatus source to improving and improving existing Transdermal absorption system.
Description of drawings
Accompanying drawing 1 is the sketch map of this utility model fixed mount;
Accompanying drawing 2 is the sketch map of this utility model needle roller;
Accompanying drawing 3 is dynamics and depth relationship curve;
Accompanying drawing 4, be the experiment effect figure (Franz diffusion cell method) of transdermal administration;
Accompanying drawing 5, be the experimental result picture of matched group;
Accompanying drawing 6, be experimental group (use micropin group) experimental result picture;
More than in the diagram:
1, hands handle; 2, roller mount; 3, needle body; 4, roller bearing; 6, support; 7, roller bearing hole;
9, the junction of handle 1 and support 6.
The specific embodiment
This utility model has been studied existing Transdermal absorption device, and a kind of new Transdermal absorption product and structure and purposes are provided, and is convenient to improve looks, the safe and effective use of industry such as medicine.
The skin needle roller is introduced existing micropin scroll techniques, and its device is transformed, and makes it to possess multiple function.This apparatus can be applicable to the Transdermal absorption of beauty parlor, hospital, research institution and uses, and is conducive to improve the transdermal drag delivery system, and application promise in clinical practice is arranged.
In this utility model, the embodiment of the above-described specific embodiment and the following stated all is in order to set forth this utility model better, is not to limit scope of the present utility model.Be described in detail below by this utility model of embodiment.
This utility model finally need be prepared into the Transdermal absorption product and use, and will enumerate embodiment below and further specify.Provide several Transdermal absorption products and using method and some experimental study contents by aforementioned summary of the invention in the above-described specific embodiment and the following example, but should be appreciated that this utility model is not limited in listed research contents herein, should also be appreciated that term as used herein only is used for describing certain embodiments, and be not to restriction of the present utility model.
Now with regard to this utility model device, specifically be described below:
Shown in Fig. 1～2, this utility model relates to a kind of skin needle roller, it comprises roller mount 2, be arranged at a plurality of needle bodies 3 on the external peripheral surface of described roller mount 2, the diameter of described each needle body 3 is 0.07～0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1～0.3 millimeter.The axial line place of described roller mount 2 offers roller bearing hole 7, can insert roller bearing 4 in roller bearing hole 7, be installed in roller bearing 4 on the support 6 after, roller mount 2 can be rotated around self axial line.The rear portion of support 6 has handle 1, the operator can hold handle 1 and promote it, support 6 is moved, the roller mount 2 that is pivotally connected on the support 6 is namely rolled at the skin of human body, thereby extract rapidly after driving the epidermal tissue that needle body 3 pierces through skin, make 3 pairs of epidermises of needle body cause small wound and reach dermal tissue, and for the natural reaction to the epidermis tissue injury, dermal tissue namely can be made the epidermal tissue that makes new advances and go to repair these small wounds, thereby reaches effect young, healthization skin.
This skin needle roller can be applicable to massage health and the facial skin of human body, utilizes natural method to stimulate the ossein hypertrophy by needle body 3, and can not destroy skin epidermis, thereby promote the regeneration function of skin, reaches cosmetic result; This skin needle roller also can be applicable to massage the skin of head of human body, select the scalp massage of 3 pairs of human bodies of needle body of appropriate diameter for use, cause small wound by the epidermal tissue that gives scalp, can promote the blood circulation of scalp, stimulate the growth of hair, to reach the hair caring effect.
In the embodiment that this utility model adopts usually, described a plurality of needle bodies 3 are pressed 3～9 column distributions in roller mount 2.In the following preferred embodiment, needle body 3 is distributed as 7 row, described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2, be that each individuality in every row needle body 3 is arranged along the circumferencial direction of roller mount 2 equally spacedly, this makes this utility model when using, the epidermal tissue of 3 pairs of skins of needle body causes uniform wound, and dermal tissue will produce uniformly new epidermal tissue, thereby can improve cosmetic result.
Utilize the device of technical solutions of the utility model, particular content is as follows:
Get 8 stripped nude mice skin of back, handle with transforming skin needle roller (500 μ m pins are long).The use dynamics is 2.5,5,7.5,10,12.5,15,17.5 respectively, 20N, and dynamics is controlled with electronic balance.Subsequently with methylene blue solution dyeing 2 minutes, clear water flush away dye liquor.After above-mentioned skin wiped moisture and residual dye with dry cotton ball, be cut into the fritter of 1cm * 0.5cm, liquid nitrogen cryogenics was freezing after tissue immersed OCT liquid subsequently, spent the night, and took out the back and cut into slices under freezing state, and microscopically is observed length and the record of micro hole.Experimental result (table 1, Fig. 3):
Table 1, micropin use dynamics and depth relationship research
After the micropin roller was transformed, protective cover made skin smooth during use, and rolling is carried out easily, and simultaneously, the diversity that micropin thrusts skin depth under identical dynamics reduces, and uses easy operating.
The effectiveness of embodiment 2, transdermal administration (Franz diffusion cell method) research
Utilize the device of technical solutions of the utility model, particular content is as follows:
Get 2 nude mice skins, remove subcutaneous tissue, normal saline flushing.Blank group is handled without micropin, and experimental group is handled with transforming the micropin roller.Blank group and experimental group skin are fixed in Franz between coyote hole and the receiving chamber, and stratum corneum side is to giving coyote hole, and effectively infiltrating area is 0.85cm
2(isopropyl alcohol: normal saline=1:1) until closely contact (4ml) with skin, get rid of bubble places (37.0 ± 0.5) ℃ water bath with thermostatic control, (200 ± 1) r/min constant speed electromagnetic agitation to add water alcoholic solution in the receiving chamber.0.2g tretinoin emulsifiable paste is applied on the Corium Mus horny layer, respectively at 1,2,3,4,5,6,8,10,12h takes out 0.2ml and receive liquid (getting the water-alcohol solution that replenishes equivalent behind the liquid rapidly), surveys concentration with HPLC.Calculate the accumulation infiltration capacity.The lucifuge operation.
Calculate each by accumulation infiltration capacity formula and accumulate infiltration capacity constantly.Formula is:
Wherein: Q is the accumulation infiltration capacity, receives liquid Chinese medicine concentration when Cn be this sub-sampling, and V is acceptable solution volume in the receiving chamber, and Ci is the first time of acceptable solution Chinese medicine concentration during to previous sample, and S is i sub-sampling amount.
After using transformation micropin roller, the drug osmotic amount obviously increases, and compares with experimental group and improves 4 times of (see figure 4)s approximately.
Utilize the device of technical solutions of the utility model, particular content is as follows:
Handle with repacking micropin roller nude mice anesthesia back, handle back 3d and put to death nude mice, the skin histology of skin administration of learning from else's experience is fixing with 10% formaldehyde (PBS dilution), ethanol dehydration, paraffin embedding, section (5 μ m), put on the microscope slide, HE dyeing, the reaction of microscopically tissues observed and inflammatory cell situation are taken pictures.Without the micropin processing is matched group.
The HE dyeing course:
1. hematoxylin dye liquor dyeing 5～15min.
2. flowing water washes 3～5min.
3. 0.5～1% hydrochloride alcohol solution breaks up the several seconds.
4. flowing water flushing, weak alkaline aqueous solution shows blue 1min.
5. eosin stain dyeing 10min.
6. washing, the dehydration of ethanol gradient, dimethylbenzene is transparent.
7. mounting, put the absorbent paper of a cleaning on the table, the microscope slide that will contain material takes out from dimethylbenzene and is placed on (the section one side upwards) on the paper, promptly drip natural gum (carrying out again after must not treating the dimethylbenzene drying) in the central authorities of section, hold the right side that pincet is clamped coverslip lightly with the right hand, tilt to make its left side and envelope to hide agent a little and contact, and then put down lentamente, avoid producing bubble.
The HE coloration result: matched group (see figure 5) microscopically tissue is normal, uses micropin group (see figure 6) and matched group not to have significant difference epidermal area and skin corium and organizes and do not show inflammatory reaction.
Claims (5)
1. a skin needle roller is characterized in that, described this skin needle roller comprises fixed mount, two parts of needle roller;
Described fixed mount comprises handle (1), the support (6) by 1 flexible connection of junction (9) and handle, the roller bearing (4) that is connected with support (6);
Described needle roller comprises roller mount (2), be arranged at a plurality of needle bodies (3) on the external peripheral surface of described roller mount (2), the roller bearing hole of offering at the axial line place of roller mount (2) (7); By roller bearing (4) with roller mount (2) pivotal mounting on support (6);
Described roller mount (2) is a hollow cylinder, and employed material has elasticity;
Described needle body (3) is hollow needle body, is directly fixed on the external peripheral surface of roller mount (2), distributes by multiple row.
2. skin needle roller according to claim 1 is characterized in that, described handle (1) and the junction (9) of support (6) are that the embedded mode that adopts multi-faceted slip or multi-angle to move carries out activeness and is connected.
3. skin needle roller according to claim 1 is characterized in that, described roller mount (2) is a hollow cylinder.
4. skin needle roller according to claim 1 is characterized in that, described each row needle body (3) is pressed 3～9 column distributions at the external peripheral surface of roller mount (2), and evenly arranges along the circumferencial direction of roller mount (2).
5. skin needle roller according to claim 1 is characterized in that, the diameter of described each needle body (3) is 0.07～0.35 millimeter, and the length of exposing at roller mount (2) Outboard Sections of described each needle body (3) is 0.1～3 millimeter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220697204 CN203169818U (en) | 2012-12-14 | 2012-12-14 | Skin rolling needle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220697204 CN203169818U (en) | 2012-12-14 | 2012-12-14 | Skin rolling needle |
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| Publication Number | Publication Date |
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| CN203169818U true CN203169818U (en) | 2013-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220697204 Expired - Fee Related CN203169818U (en) | 2012-12-14 | 2012-12-14 | Skin rolling needle |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120826A (en) * | 2012-12-14 | 2013-05-29 | 上海百华生物科技有限公司 | Skin rolling needle |
| US9474685B2 (en) | 2011-09-28 | 2016-10-25 | Sure-Shot Medical Device Inc. | Apparatus for localized dermatological treatment |
| CN106806985A (en) * | 2017-01-19 | 2017-06-09 | 汉典生物科技（上海）有限公司 | A kind of beauty micropin roller |
| US11432990B2 (en) | 2013-08-30 | 2022-09-06 | ISOS Solutions, LLC | Textured apparatus with therapeutic material incorporated therein and methods of manufacturing same |
-
2012
- 2012-12-14 CN CN 201220697204 patent/CN203169818U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9474685B2 (en) | 2011-09-28 | 2016-10-25 | Sure-Shot Medical Device Inc. | Apparatus for localized dermatological treatment |
| CN103120826A (en) * | 2012-12-14 | 2013-05-29 | 上海百华生物科技有限公司 | Skin rolling needle |
| CN103120826B (en) * | 2012-12-14 | 2016-04-20 | 上海百华生物科技有限公司 | A kind of skin needle roller |
| US11432990B2 (en) | 2013-08-30 | 2022-09-06 | ISOS Solutions, LLC | Textured apparatus with therapeutic material incorporated therein and methods of manufacturing same |
| CN106806985A (en) * | 2017-01-19 | 2017-06-09 | 汉典生物科技（上海）有限公司 | A kind of beauty micropin roller |
| CN106806985B (en) * | 2017-01-19 | 2023-03-31 | 汉典生物科技（上海）有限公司 | Cosmetic micropin gyro wheel |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130904 Termination date: 20131214 |