CN106806985B - Cosmetic micropin gyro wheel - Google Patents

Cosmetic micropin gyro wheel Download PDF

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Publication number
CN106806985B
CN106806985B CN201710046582.0A CN201710046582A CN106806985B CN 106806985 B CN106806985 B CN 106806985B CN 201710046582 A CN201710046582 A CN 201710046582A CN 106806985 B CN106806985 B CN 106806985B
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microneedle
roller
microneedles
boss
roller according
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CN106806985A (en
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裴为华
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Handian Biotechnology Shanghai Co ltd
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Handian Biotechnology Shanghai Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H15/00—Massage by means of rollers, balls, e.g. inflatable, chains, or roller chains
    • A61H15/02—Massage by means of rollers, balls, e.g. inflatable, chains, or roller chains adapted for simultaneous treatment with light, heat or drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H15/00—Massage by means of rollers, balls, e.g. inflatable, chains, or roller chains
    • A61H2015/0007—Massage by means of rollers, balls, e.g. inflatable, chains, or roller chains with balls or rollers rotating about their own axis
    • A61H2015/0014—Massage by means of rollers, balls, e.g. inflatable, chains, or roller chains with balls or rollers rotating about their own axis cylinder-like, i.e. rollers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
    • A61H2201/105—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy with means for delivering media, e.g. drugs or cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/12—Driving means
    • A61H2201/1253—Driving means driven by a human being, e.g. hand driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1657—Movement of interface, i.e. force application means
    • A61H2201/1671—Movement of interface, i.e. force application means rotational
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1683—Surface of interface
    • A61H2201/169—Physical characteristics of the surface, e.g. material, relief, texture or indicia
    • A61H2201/1695—Enhanced pressure effect, e.g. substantially sharp projections, needles or pyramids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/04—Skin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rehabilitation Therapy (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

The invention relates to a microneedle roller. The microneedle roller comprises a roller seat, a plurality of bosses are arranged on the peripheral surface of the roller seat, a concave part is formed between the bosses, and a microneedle array is arranged on the roller seat at the concave part. The boss is arranged on the roller seat, so that the puncturing depth of the micro-needle can be effectively controlled, and meanwhile, the micro-needle can be protected by the boss.

Description

Cosmetic micropin gyro wheel
Technical Field
The invention belongs to the technical field of medicine, cosmetology and the like, and particularly relates to a microneedle roller for transdermal cosmetology or drug delivery.
Background
A cosmetic microneedle roller is a device having a cylindrical surface on which an array of microneedles having a certain height (50-1000 microns) and diameter (10-500 microns) is mounted, as shown in fig. 1, in which the microneedles are used to pierce the stratum corneum of the outermost layer of skin, creating a pathway for nutrients or drugs to enter, and enhancing and improving the otherwise poorly permeable outer tissues of the skin. The diameter and height of the micro-needles directly affect the feeling of users and the transdermal effect of the drugs: when the height of the micro-needle is higher, the micro-needle can easily penetrate into the hair growth layer and even the dermis layer of the skin to cause pain or bleeding; microneedles with too low a height may not penetrate the stratum corneum and may not be effective. In order to ensure the effect and reduce side effects such as pain, microneedles having a sufficient length are often used, and are uniformly mounted on a roller, and are operated by a trained technician to ensure effectiveness of microneedle administration and comfort of use of the user by an appropriate method.
In order to provide a painless micropin gyro wheel device safer, more convenient, that control more easily, patent CN201210546748.2 has set up the three-dimensional safety cover that has a breach in the bottom in the periphery of gyro wheel seat, and breach department exposes the micropin, and this safety cover can make skin level and smooth, when making roll go on easily, makes the differentiation that the micropin pricked skin under the same dynamics reduce. However, the protective cover covers most of the roller seat, the inside of the protective cover is difficult to clean, and the protective cover does not protect the microneedles.
CN patent 201420807166.X provides a microneedle cosmetic device that can arrange a micro rubber suction cup around a microneedle, the skin is tightened when in use, the pain is relieved, and the operation is easier. However, the microneedles of the microneedle cosmetic device are fixed in a plane instead of being fixed on the surface of the roller, and each time the microneedle cosmetic device is used, the microneedles are required to be inserted, pulled out and inserted again after being changed in position, and uniform perforation on the skin cutin cannot be controlled.
Disclosure of Invention
The invention aims to provide a microneedle roller capable of controlling the penetration depth
The invention also aims to provide A microneedle roller without pain was used.
The invention also aims to provide the microneedle roller which is convenient to place and store.
The invention also aims to provide a microneedle roller capable of arranging the superfine microneedles.
The purpose of the invention is realized by the following means:
the invention provides a microneedle roller, which comprises a roller seat, wherein the peripheral surface of the roller seat is provided with a plurality of bosses, a concave part is formed between every two adjacent bosses, and a microneedle array is arranged on the periphery of the roller seat where the concave part is positioned, and at least two microneedles are arranged in the microneedle array.
As a result of the preferred embodiment(s), the lug boss and the roller seat are integrally formed; or the lug boss is embedded in the peripheral surface of the roller seat;
the bosses and the microneedle arrays are distributed in a staggered manner along the peripheral surface of the roller seat vertical to the axis; or the bosses and the microneedle arrays are distributed in a staggered manner along the peripheral surface parallel to the axis.
The roller seat is a hollow cylinder, and a roller shaft hole is formed in the axis of the roller seat. The roller seat can be movably mounted on the bracket through the roller hole.
The section of the boss is quadrilateral.
The section of the boss refers to: the cross section vertical to the axle center of the roller seat takes the peripheral surface connected with the roller seat as a lower bottom edge, takes the edge of the periphery of the lug boss cross section far away from the axle center as an upper bottom edge, and is a quadrangle enclosed by two side edges. The upper bottom edge and the lower bottom edge of the boss can be arc-shaped or linear, and the side edge of the boss and the lower bottom edge can form an acute angle or an approximate acute angle, a right angle or an approximate right angle, or an obtuse angle or an approximate obtuse angle. Preferably at right angles and with a chamfer. The method is favorable for fully utilizing the height of the boss and facilitating the patch operation of the micro-needle.
The lug boss and the roller seat are integrally formed, and the roller seat and the lug boss can be made of rigid materials or elastic materials.
The roller seat and the boss can be made of the materials of the existing microneedle roller, such as metal, ABS plastic, polyimide or medical plastic.
The micro-needles are arranged in a two-dimensional array in the concave part of the outer surface of the roller seat to form a micro-needle array. The arrangement density of the micro-needles is 100-500/cm 2 (ii) a Preferably 150 to 300 pieces/cm 2 (ii) a More preferably 200/cm 2 。
The microneedle array and the roller seat are integrally formed, or a microneedle array base is arranged at the bottom of the microneedle array, and the microneedle is embedded in the periphery of the roller seat through the microneedle array base.
The shape of the micro-needle is a taper shape, such as a circular truncated cone, a triangular truncated cone, a rectangular truncated cone, a knife edge, a wedge shape and the like; or the upper end of the micro-needle is in a sharp cone shape, and the lower end of the micro-needle is in a column shape, such as a cylinder, a prism, a rectangular pyramid and the like. In a preferred embodiment of the present invention, the microneedles have a truncated cone at the upper end and a cylindrical shape at the lower end (see fig. 3 or 4), and such a structure is configured that the diameter of the holes penetrated into the skin is uniform no matter how deep the microneedles are penetrated into the skin, and no mark is left on the skin due to the increase of the penetration depth. In an embodiment of the present invention, the microneedles are conical (see fig. 1).
The micro-needle can be a hollow needle body or a solid needle body. The micro-needle can directly penetrate into the skin cuticle to improve the permeability of the skin, and can also penetrate into the skin cuticle after carrying beauty products or medicines.
The height of the micro-needle is 100-1000 μm; preferably 80-200 μm; more preferably 100 μm. The height of the micro-needle is the height of the micro-needle exposed on the outer surface of the roller seat.
The height difference between the boss and the microneedle is 0-500 μm; the difference in height is preferably 0 to 20 μm, more preferably 0 μm. When the height difference is 0, the skin can be protected by the boss structure with a smooth surface, and the micro-needle can penetrate into the skin to a certain depth. In addition, the height difference between the boss and the microneedle can be adjusted according to the actual use condition, so that the microneedle is lower than the boss.
The height difference between the boss and the microneedle is the height of the boss minus the height of the microneedle. The height of the boss is obtained by subtracting the radius of the roller seat from the distance from the highest point of the boss to the circle center of the roller seat; the height of the micro-needle is the height of the micro-needle exposed on the outer surface of the roller seat.
The diameter of the microneedle is 10-500 μm; preferably 80-200 μm; more preferably 100 μm. The diameter of the microneedle is represented by the diameter of the microneedle with a circular or nearly circular base.
When the microneedle roller of the present invention is applied to the skin with slight force by the user, the microneedles hardly contact the skin; when the user applies proper force according to the feeling of the skin, the skin pressed by the boss can be squeezed into the concave part, so that the part of the skin receives the action of the micro-needle and is perforated on the stratum corneum. Compared with the common microneedle roller, the microneedle penetration depth is controlled by the accurate force-adjusting scale of the user. Due to the self-stopping and squeezing action of the lug boss, the microneedle penetration degree control becomes simple and easy to operate, a professional technician is not needed, and a common user can use the microneedle penetration degree control device by himself.
In addition, due to the extrusion effect of the boss, the skin is in a certain tight state, and the pain feeling of the microneedle penetrating the skin is relieved.
Due to the protection of the boss, thinner microneedles can be used without fear of damage or breakage of the microneedles, which further reduces the pain of piercing the skin. In the present invention, the diameter of the microneedles may be as low as 10 microns.
In summary, the projections are configured so that the microneedles of the present invention penetrate the skin without any pain and maintain an effective penetration depth without involvement of the dermis.
The invention has the beneficial effects that:
1) The invention has simple operation and no pain: the extrusion and self-stop of the lug boss can control the penetration depth without professional operation technology; the skin is in a certain tightening state by the extrusion of the lug boss, so that the pain of the puncture is relieved; the protection of the boss can use thinner micro-needles to further reduce the pain of the puncture.
2) The protection of the boss can use thinner micro-needles without worrying about the damage or the breakage of the micro-needles, the diameter of the micro-needles is reduced, the pain feeling of the micro-needles stabbed into the skin is further reduced, and the tiny micropores can not leave marks on the skin.
3) The interval of boss and micropin array has reduced the degree of difficulty of micropin gyro wheel in storage, place and packing link and has kept clear degree of difficulty, and the user need not too worry the needle point barb or the damage that cause the gyro wheel to keep flat.
Drawings
FIG. 1 is a schematic cross-sectional view of a microneedle roller in the prior art
FIG. 2 is a schematic cross-sectional view of a microneedle roller according to example 1 of the present invention
FIG. 3 is a schematic cross-sectional view of a microneedle roller according to example 2 of the present invention
FIG. 4 is a schematic cross-sectional view of a microneedle roller according to example 3 of the present invention
FIG. 5 is a schematic cross-sectional view of a microneedle roller according to example 4 of the present invention
Note: the section is a section vertical to the central shaft of the hollow cylinder roller seat
1. Roller seat
2. Boss
3. Concave part
4. Microneedle array
5. Microneedle
6. Roller shaft hole
7. Microneedle array base
8. Upper bottom edge
9. Side edge
10. Bottom edge
Detailed Description
The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.
Example 1
The microneedle roller shown in fig. 2 comprises a roller base 1, wherein the roller base 1 is a hollow cylinder, and a roller hole 6 is formed at the axis of the roller base. The periphery of the roller seat is provided with a plurality of bosses 2. The lower bottom edge 10 of the boss 2 is the peripheral surface connected with the roller seat, the upper bottom edge 8 of the boss 2 is a straight line, and the side edge 9 of the boss 2 and the lower bottom edge 10 form an acute angle;
a concave part 3 is formed between the bosses. The micro-needle array 4 is arranged at the concave part 3. The microneedle array 4 is embedded at the periphery of the roller seat through a microneedle array base 7. The microneedle array 4 was provided at a density of 200 pieces/cm 2 Microneedles 5 are arranged. The micro-needle 5 is in a solid conical shape. The height of the microneedles 5 is 100 micrometers, and the diameter of the microneedles 5 is 100 micrometers at the thickest. The height difference between the microneedle 5 and the boss 2 is 0.
Example 2
Example 1 was repeated with the microneedle roller as described in fig. 3, with the following differences:
the arrangement density of the microneedle array is 100/cm 2 ；
Microneedles are 200 microns in height and 150 microns in diameter;
the height difference between the boss and the microneedle is 20 micrometers;
the microneedle array does not contain a microneedle array base, and the microneedles and the roller base are integrally formed.
Example 3
Example 1 was repeated with the microneedle roller shown in fig. 4, with the following differences:
the arrangement density of the microneedle array is 400 pieces/cm 2 ；
Microneedles are 30 microns in height; a diameter of 10 microns;
the microneedle has a conical shape at the upper end and a cylindrical shape at the lower end.
The height difference between the boss and the microneedle is 0;
the upper base edge of the boss is a straight line, and the side edge of the boss is at a right angle with the lower base edge.
Example 4
Example 1 was repeated with the microneedle roller as described in fig. 5, with the following differences:
the arrangement density of the microneedle array is 180 pieces/cm 2 ；
The height of the microneedles is 100; a diameter of 80;
a hollow cylinder of microneedles;
the upper bottom edge of the boss is an arc line, and the side edge of the boss and the lower bottom edge form an obtuse angle.

Claims (20)

1. A microneedle roller comprises a roller seat, wherein a plurality of bosses are arranged on the peripheral surface of the roller seat; a concave part is formed between the adjacent bosses, a microneedle array is arranged on the periphery of the roller seat where the concave part is located, and at least two microneedles are arranged on the microneedle array; the height of the micro-needle is equal to or lower than that of the boss, the height difference between the boss and the micro-needle is 0-20 μm, the cross section of the boss is quadrilateral, and the upper bottom edge of the quadrilateral is arc-shaped or linear.
2. A microneedle roller according to claim 1, wherein the roller base is a hollow cylinder.
3. A microneedle roller according to claim 1, wherein said boss is integrally formed with the roller base; or the lug boss is embedded in the peripheral surface of the roller seat.
4. A microneedle roller according to claim 1, wherein the height of the microneedles is 50-1000 μm.
5. A microneedle roller according to claim 4, wherein the height of the microneedles is 80-200 μm.
6. A microneedle roller according to claim 5, wherein the height of the microneedles is 100 μm.
7. A microneedle roller according to claim 1, wherein the diameter of the microneedle is 10-500 μm.
8. A microneedle roller according to claim 7, wherein the diameter of the microneedles is 80-200 μm.
9. A microneedle roller according to claim 8, wherein the diameter of the microneedles is 100 μm.
10. A microneedle roller according to claim 1, wherein the difference in height between the boss and the microneedle is 0 μm.
11. The microneedle roller according to claim 1, wherein the microneedles are tapered, or the microneedles have tapered upper ends and cylindrical lower ends.
12. A microneedle roller according to claim 1, wherein the microneedles are solid or hollow needles.
13. A microneedle roller according to claim 1, wherein the material of the microneedles is one of silicon, metal, organic material, glass or quartz.
14. The microneedle roller according to claim 1, wherein the arrangement density of microneedles in said microneedle array is 100-500 microneedles/cm 2 。
15. The microneedle roller according to claim 14, wherein the arrangement density of microneedles in the microneedle array is 150 to 300/cm 2 。
16. The microneedle roller of claim 15, wherein the microneedles of the microneedle array are arranged at a density of 200 microneedles/cm 2 。
17. A microneedle roller according to claim 1, wherein the microneedle array is integrally formed with the roller base; or the microneedle array also comprises a microneedle array base, and the microneedle array is embedded in the roller base through the microneedle array base.
18. A microneedle roller according to claim 1, wherein the roller base is a hollow cylinder; the axle center of the roller seat is provided with a roller hole.
19. A microneedle roller according to any of claims 1 to 18, wherein the projections are staggered with respect to the microneedle array along a peripheral surface perpendicular to the axis of the roller base; or the bosses and the microneedle arrays are distributed in a staggered manner along the peripheral surface parallel to the axis of the roller seat.
20. The microneedle roller according to claim 1, wherein the microneedle roller is a cosmetic or medical microneedle roller.
CN201710046582.0A 2017-01-19 2017-01-19 Cosmetic micropin gyro wheel Active CN106806985B (en)

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CN106806985B true CN106806985B (en) 2023-03-31

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WO2010101620A2 (en) * 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin
JP2013158601A (en) * 2012-02-08 2013-08-19 Toppan Printing Co Ltd Microneedle chip and method of manufacturing the same
CN203169818U (en) * 2012-12-14 2013-09-04 上海百华生物科技有限公司 Skin rolling needle
CN203379477U (en) * 2012-12-14 2014-01-08 上海市第七人民医院 Micro-needle roller device
KR20140044098A (en) * 2012-10-04 2014-04-14 공광열 Microneedle roller

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