CN108743452A - It is a kind of to breathe bionical skin protection cosmetics and preparation method certainly - Google Patents
It is a kind of to breathe bionical skin protection cosmetics and preparation method certainly Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/544—Dendrimers, Hyperbranched polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/61—Surface treated
- A61K2800/62—Coated
- A61K2800/622—Coated by organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/60—Particulates further characterized by their structure or composition
- A61K2800/65—Characterized by the composition of the particulate/core
- A61K2800/654—The particulate/core comprising macromolecular material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The present invention relates to a kind of from bionical skin protection cosmetics and preparation method is breathed, and belongs to cosmetic technical field.The technical problem to be solved by the present invention is to provide a kind of from the bionical skin protection cosmetics of breathing and preparation method.The molten chitosan solution of acid is uniformly dispersed by this from the preparation method for breathing bionical skin protection cosmetics with crosslinked hyperbranched poly lysine, polvmeric lipid ball, aerosil, and spray drying obtains micropore micro mist；Micropore micro mist and high molecular weight protein, spermaceti, allantoin etc. are prepared by mixing into cream again, due to the good uniform micropore and automatic humidity-regulating respiratory of micropore micro mist, there can be good permeable moisture-inhibiting regulatory function to skin, biocompatibility is preferable, has the function of bionics skin, it effectively prevent the micropore of film forming layer to be blocked, improves skin elasticity and moistening effect.In addition, the preparation method from the bionical skin protection cosmetics of breathing of the present invention, step is few, and flow is simple, and safe operation is at low cost.
Description
Technical field
The present invention relates to a kind of from bionical skin protection cosmetics and preparation method is breathed, and belongs to cosmetic technical field.
Background technology
As people are to beautiful pursuit and the improvement of people's living standards, cosmetics are for many people, and especially one
A little daily skin care, hairdressing, cleaning supplies etc. have become the necessity of many Mies, there is an a large amount of people especially women, and one
The four seasons in year are all using different types of cosmetics.For the mankind skin the problem of carry out protection be the most basic category of cosmetics
Property.Such as pigmentation, skin dimness are required for using cosmetics greatly.With the dosage directly with the cosmetics of skin contact
Increasing, we have to take into account that the safety problem and environmental issue of cosmetics.Existing conventional cosmetics mostly use height
Grade aliphatic compound, because all there are one shorter hydrophilic radical and a long lipophilic groups in the molecule of these materials
Group, thus they can well be combined with skin, and one layer of separation layer is formed in skin surface, this is to preventing skin dehydration from having centainly
Effect, to which direct or indirect protects skin.It is environmentally protective in order to pursue, it is more and more at present to use various natural makeups
Product, such as aloe, ginseng, placenta, but due to lacking the good contact with human skin, using effect is not obvious.
Therefore, it is particularly important that the environmentally protective cosmetics high with skin biology fitness are developed.It is desirable that cosmetics exist
Skin surface can generate one layer of firm protective layer, and to keep out extraneous micronic dust, bacterium, the protective layer being formed simultaneously has
Excellent breathable moisture permeability does not influence skin and plays original function.For this purpose, cosmetics of the research with bionics skin function become
The trend of future development.
Application No. is 201710345015.5 Chinese invention patent disclose a kind of cream for sensitive skin and its
Preparation method, the cream include following component in percentage by weight：Lecithin 0.01~2%；Phytosterol 0.1~
2%；Ceramide 0.01~2%；Niacinamide 0.1~2%；Anti-inflammatory bacteriostatic agent 0.1~1%；Auxiliary material, surplus.This is used for sensitivity
The cream of skin can repair skin barrier, form one layer of biomimetic liquid crystals film in skin surface, increase skin " thickness ", reduce skin
Skin is to extraneous cold and hot, stimulus sensitivity；Contain antiallergic ingredient in cream, antiallergic ingredient can be in root for by the external world
The stress reaction of blood vessel and cell caused by stimulation or damage, useful effect inhibit inflammation, allergy of releiving in inflammatory mediator
Skin, promote sensitive skin to restore.
Application No. is 201710083728.9 Chinese invention patents to disclose a kind of moisture-keeping composition and preparation method thereof
And application, moisture-keeping composition include the component of following parts by weight：1.0~5.0 parts of Sodium Hyaluronate, carboxymethylchitosan
2.0~10.0 parts, 30.0~60.0 parts of dendrobium candidum extract, 25.0~67.0 parts of deionized water.The composition can be more preferable
Ground forms a netted natural Biomimetic membranes, Sodium Hyaluronate replenishing water and preserving moisture inside Biomimetic membranes, the deacetylated shell of carboxymethyl with skin
Polysaccharide forms bionical sterile film, effectively blocks the natural moisturizing factor such as Sodium Hyaluronate, reduces percentage of water loss, while iron sheet stone
Dry measure used in former times polysaccharide is combined with natural bionical sterile film to be further increased the moisturizing persistence of long-time service, enhances repairing effect, from basic
Upper solution dry skin, allergic problem.This moisture-keeping composition has moisturizing, reparation, the various dimensions work(for enhancing skin barrier function
Effect.
Application No. is 201711467660.0 Chinese invention patents to disclose a kind of bionic phospholipid repair cream and its preparation
Method.The repair cream includes following components：Bionic phospholipid, saualane, jojoba oil, hard ester alcohol, hard ester alcohol polyacetals -2, hard ester
Alcohol polyacetals -21, dimethyl silicone polymer, tocopherol, Nipasol, glycerine, propylene glycol, Sodium Hyaluronate, collagen extract, urine
Bursin, methyl hydroxybenzoate, imidazolidinyl urea, essence, deionized water.The repair cream of the invention is by raw material components according to certain quality
Score carries out organic assembling, and the repair cream prepared, not only repairing effect is good, and cold and hot stability is more excellent, meanwhile, repair cream also has
There is the function of anti-aging, and improves skin elasticity.
As it can be seen that existing biomimetic material, is mostly using higher aliphatics as main material, film forming is poor, even if
Film forming is also easily broken.And existing cosmetics are to be directly added into macromolecule filming material, cause the film gas permeability to be formed compared with
Difference, it is difficult to match with the air-moisture-permeable of skin and from breathing.
Invention content
It is poor for existing skin protection cosmetics safeguard function, it directly is difficult to be formed using macromolecule filming object matched with skin
The defects of ventilative, penetrability, the present invention provide a kind of from breathing bionical skin protection cosmetics and preparation method.
First technical problem that the present invention solves is to provide a kind of from the preparation method for breathing bionical skin protection cosmetics.
The present invention includes the following steps from the preparation method for breathing bionical skin protection cosmetics：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, is stirred to being completely dissolved, it is 5~10% to obtain mass concentration
The molten chitosan solution of acid；By lysine hydrochloride with caustic alkali under protective atmosphere, 140~160 DEG C react acquisition be in branch
The crosslinked hyperbranched poly lysine of shape；
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, addition polvmeric lipid ball,
Aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 20~40 parts of the chitosan solution of acid surpasses
10~30 parts of branched polylysine, 5~15 parts of polvmeric lipid ball, 2~10 parts of aerosil；
C, batch mixing：By micropore micro mist and high molecular weight protein, spermaceti, allantoin, glycerine, vitamin E, vitamin B3, octyl
Lauryl alcohol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionized water, and modulation becomes paste to get breathing certainly
Bionical skin protection cosmetics；Wherein, by weight, 20~40 parts of micropore micro mist, 20~40 parts of high molecular weight protein, spermaceti 10
~30 parts, 1~10 part of allantoin, 10~20 parts of glycerine, 1~10 part of vitamin E, 1~10 part of vitamin B3, octyl dodecanol
1~10 part of myristic acid fat, 1~8 part of dimethyl siloxane, 2~6 parts of linoleic acid.
The method of the present invention, by the molten chitosan solution of acid and crosslinked hyperbranched poly lysine, polvmeric lipid ball, titanium dioxide
Silica aerogel is uniformly dispersed, and spray drying obtains micropore micro mist；The micropore micro mist has good uniform micropore and automatic humidity-regulating
Respiratory has skin good for applying after skin forms a film by the hydrophobic balance of hydrophilic group and aerosil
Permeable moisture-inhibiting regulatory function, and biocompatibility is preferable, has the function of bionics skin, effectively prevent the micropore quilt of film forming layer
It blocks.
Step A is mainly to prepare the process of acid molten chitosan solution and hyperbranched poly lysine.
The molten chitosan solution of acid only needs to dissolve chitosan in acid solution.It is excellent in order to improve the quality of cosmetics
Choosing, the mass concentration of the molten chitosan solution of acid is 8%.
Hyperbranched poly lysine is mainly branched with caustic alkali using lysine hydrochloride and is obtained by the reaction.
Lysine hydrochloride, i.e. L lysine HCL are also lysine hydrochloride, chemical molecular formula C6H14N2O2
HCL, for white or the crystalline powder of near-white free mobility.It is almost odorless.263 ~ 264 DEG C melt and decompose.Usually compared with
Stablize, 60% or less high humility is stablized, and 60% or more then generates dihydrate.Alkaline condition and directly with heated in the presence of reduced sugar
Then decompose.
Caustic alkali is the general designation that alkali metal and monovalence silver, monovalence thallium correspond to hydroxide, such as sodium hydroxide, hydroxide
Potassium, rubidium hydroxide etc..Since their aqueous solution or other solution have strong corrosion effect to fur, skin, paper etc.（Such as
The ammonia spirit of sodium hydrate aqueous solution energy strong corrosion paper, silver hydroxide can be with strong corrosion skin）, thus have " causticity "
Name.
It aoxidizes in order to prevent, needs to use protective atmosphere.Protective atmosphere commonly used in the art is suitable for the present invention, preferably
, the protective atmosphere is argon gas atmosphere, neon atmosphere, helium atmosphere, Krypton atmosphere, xenon atmosphere or nitrogen atmosphere.
Preferably, the caustic alkali is sodium hydroxide or potassium hydroxide.
Preferably, in step A, reaction temperature is 150 DEG C, and the reaction time is 10~20h.
Step B is to prepare the process of micropore micro mist, and the molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, is added
Enter polvmeric lipid ball, aerosil, spray drying obtains micropore micro mist.
Wherein, it is preferred that the polvmeric lipid ball is using polyurethane as skeleton, and phospholipid layer is coated on poly- outside skeleton
Object lipid ball is closed, the hydrophobic tail end of the phospholipid molecule of phospholipid layer is embedded in inside polyurethane skeleton, and hydrophilic group is exposed to appearance
Face.
The prior art may be used in the preparation method of the polvmeric lipid ball, such as using common polymer microballoon
Preparation method can be prepared, and not elaborate herein.
Aeroge, also known as xerogel.When gel sloughs most of solvent, keep content liquid in gel fewer than solid content
The medium much or in the space net structure of gel being full of is gas, and appearance is in solid-like, this is xerogel, also referred to as
Aeroge.Such as gelatin, Arabic gum, silica gel, hair, nail.Aeroge also has the property of gel, that is, have expansion, touch
Change effect, synaeresis.Aerosil, that is, silica aerogel, have unique meso-hole structure and performance, of the invention two
Conventional method preparation, such as the pyrolysis method of sol-gal process, organo-metallic compound, solvent may be used in silica aerogel
The precipitation method or chemical vapour deposition technique etc. can also use commercially available aerosil.
Preferably, in step B, by weight, molten 30 parts of the chitosan solution of acid, hyperbranched poly lysine 20
Part, 12 parts of polvmeric lipid ball, 8 parts of aerosil.
Step C is the process that batch mixing prepares cream, by micropore micro mist and high molecular weight protein, spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly.
Wherein, the molecular weight of high molecular weight protein is 60~200kD.The high molecular weight protein may be used commercially available
's.
Spermaceti is white through solid wax, highly finished product obtained by cooling and squeezing from the fatty material that sperm whale head extracts
Color, it is odorless, it is glossy.41~49 DEG C of solidification point.It is dissolved in ether and carbon disulfide, it is not soluble in water, it can part in aqueous alkali
Saponification forms emulsion.Certain spermaceti is added in the cosmetics of the present invention, may be used as the thickening agent of cosmetics.
Allantoin, alias Allantoin, Allantoin, Allantion, Allantoin are a kind of second
Interior ureide derivative.Allantoin is a kind of amphoteric compound, can in conjunction with many kinds of substance formed double salt, have be protected from light, sterilization and anticorrosion,
Analgesic, antioxidation can make skin keep moisture content, moisten and soft, certain allantoin is added in cosmetics of the invention,
Have the effects that protective tissue, it is hydrophilic, absorb water and prevent moisture from distributing.
Preferably, in step C, by weight, 32 parts of micropore micro mist, 30 parts of high molecular weight protein, spermaceti
21 parts, 6 parts of allantoin, 16 parts of glycerine, vitamin E 5,4 parts of vitamin B3,5 parts of octyl dodecanol myristic acid fat, dimethyl
4 parts of siloxanes, 4 parts of linoleic acid.
Second technical problem that the present invention solves is to provide a kind of from the bionical skin protection cosmetics of breathing.
The present invention is from bionical skin protection cosmetics is breathed, using above-mentioned from the preparation method system for breathing bionical skin protection cosmetics
It is standby to obtain.In the cosmetics, micropore micro mist has good uniform micropore and automatic humidity-regulating respiratory, for applying skin film forming
Afterwards by the hydrophobic balance of hydrophilic group and aerosil, there is good permeable moisture-inhibiting regulatory function, Er Qiesheng to skin
Object compatibility is preferable, has the function of bionics skin, and the micropore of film forming layer is effectively prevent to be blocked.
Compared with prior art, the present invention has the advantages that：
The method of the present invention, by the molten chitosan solution of acid and crosslinked hyperbranched poly lysine, polvmeric lipid ball, silica gas
Gel dispersion is uniform, and spray drying obtains micropore micro mist；Again by micropore micro mist and high molecular weight protein, spermaceti, allantoin etc.
It is prepared by mixing into cream, due to the good uniform micropore and automatic humidity-regulating respiratory of micropore micro mist, can be had to skin good
Permeable moisture-inhibiting regulatory function, biocompatibility is preferable, has the function of bionics skin, and the micropore of film forming layer is effectively prevent to be blocked
Plug improves skin elasticity and moistening effect.In addition, the preparation method from the bionical skin protection cosmetics of breathing of the present invention, step
Few, flow is simple, safe operation, at low cost.
Specific implementation mode
In the following, the present invention will be further described in detail by way of specific embodiments, but this should not be interpreted as to the present invention
Range be only limitted to example below.Without departing from the idea of the above method of the present invention, according to ordinary skill
The various replacements or change that knowledge and customary means are made, should be included in the scope of the present invention.
Embodiment 1
It is prepared with the following method from the bionical skin protection cosmetics of breathing：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, stirs and obtains the acid that mass concentration is 5% to being completely dissolved
Molten chitosan solution；By lysine hydrochloride with caustic alkali sodium hydroxide under argon atmosphere, 140 DEG C react 20h acquisition
In the crosslinked hyperbranched poly lysine of dendroid.
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, polymer fat is added
Matter ball, aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 20 parts of the chitosan solution of acid,
10 parts of hyperbranched poly lysine, 5 parts of polvmeric lipid ball, 10 parts of aerosil；The polvmeric lipid ball is with poly-
Urethane is skeleton, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, and the hydrophobic tail end of the phospholipid molecule of phospholipid layer is inlayed
Inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
C, batch mixing：By micropore micro mist and high molecular weight protein（Molecular weight is 60~200kD）, it is spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly；Wherein, by weight, 20 parts of micropore micro mist, macromolecule
Measure 40 parts of protein, 10 parts of spermaceti, 1 part of allantoin, 10 parts of glycerine, 10 parts of vitamin E, 1 part of vitamin B3, octyl dodecanol
1 part of myristic acid fat, 1 part of dimethyl siloxane, 2 parts of linoleic acid.
Embodiment 2
It is prepared with the following method from the bionical skin protection cosmetics of breathing：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, is stirred to being completely dissolved, it is 10% to obtain mass concentration
The molten chitosan solution of acid；By lysine hydrochloride with caustic alkali potassium hydroxide under nitrogen protection atmosphere, 160 DEG C react 10h and obtain
It is in the crosslinked hyperbranched poly lysine of dendroid to obtain.
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, polymer fat is added
Matter ball, aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 40 parts of the chitosan solution of acid,
30 parts of hyperbranched poly lysine, 15 parts of polvmeric lipid ball, 2 parts of aerosil；The polvmeric lipid ball is with poly-
Urethane is skeleton, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, and the hydrophobic tail end of the phospholipid molecule of phospholipid layer is inlayed
Inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
C, batch mixing：By micropore micro mist and high molecular weight protein（Molecular weight is 60~200kD）, it is spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly；Wherein, by weight, 40 parts of micropore micro mist, macromolecule
Measure 20 parts of protein, 30 parts of spermaceti, 10 parts of allantoin, 20 parts of glycerine, 1 part of vitamin E, 10 parts of vitamin B3, octyl 12
10 parts of alcohol myristic acid fat, 8 parts of dimethyl siloxane, 6 parts of linoleic acid.
Embodiment 3
It is prepared with the following method from the bionical skin protection cosmetics of breathing：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, stirs and obtains the acid that mass concentration is 6% to being completely dissolved
Molten chitosan solution；By lysine hydrochloride with caustic alkali sodium hydroxide under argon atmosphere, 150 DEG C react 12h acquisition
In the crosslinked hyperbranched poly lysine of dendroid.
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, polymer fat is added
Matter ball, aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 25 parts of the chitosan solution of acid,
12 parts of hyperbranched poly lysine, 8 parts of polvmeric lipid ball, 4 parts of aerosil；The polvmeric lipid ball is with poly- ammonia
Ester is skeleton, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, and the hydrophobic tail end of the phospholipid molecule of phospholipid layer is embedded in
Inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
C, batch mixing：By micropore micro mist and high molecular weight protein（Molecular weight is 60~200kD）, it is spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly；Wherein, by weight, 25 parts of micropore micro mist, macromolecule
Measure 35 parts of protein, 28 parts of spermaceti, 9 parts of allantoin, 17 parts of glycerine, 2 parts of vitamin E, 8 parts of vitamin B3, octyl dodecanol
9 parts of myristic acid fat, 1 part of dimethyl siloxane, 3 parts of linoleic acid.
Embodiment 4
It is prepared with the following method from the bionical skin protection cosmetics of breathing：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, stirs and obtains the acid that mass concentration is 7% to being completely dissolved
Molten chitosan solution；By lysine hydrochloride with caustic alkali potassium hydroxide under argon atmosphere, 150 DEG C react 16h acquisition
In the crosslinked hyperbranched poly lysine of dendroid.
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, polymer fat is added
Matter ball, aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 35 parts of the chitosan solution of acid,
28 parts of hyperbranched poly lysine, 10 parts of polvmeric lipid ball, 8 parts of aerosil；The polvmeric lipid ball is with poly-
Urethane is skeleton, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, and the hydrophobic tail end of the phospholipid molecule of phospholipid layer is inlayed
Inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
C, batch mixing：By micropore micro mist and high molecular weight protein（Molecular weight is 60~200kD）, it is spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly；Wherein, by weight, 25 parts of micropore micro mist, macromolecule
Measure 35 parts of protein, 25 parts of spermaceti, 7 parts of allantoin, 14 parts of glycerine, 6 parts of vitamin E, 2 parts of vitamin B3, octyl dodecanol
2 parts of myristic acid fat, 7 parts of dimethyl siloxane, 5 parts of linoleic acid.
Embodiment 5
It is prepared with the following method from the bionical skin protection cosmetics of breathing：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, stirs and obtains the acid that mass concentration is 9% to being completely dissolved
Molten chitosan solution；By lysine hydrochloride with caustic alkali sodium hydroxide under nitrogen protection atmosphere, 150 DEG C react 18h acquisition
In the crosslinked hyperbranched poly lysine of dendroid.
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, polymer fat is added
Matter ball, aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 28 parts of the chitosan solution of acid,
15 parts of hyperbranched poly lysine, 8 parts of polvmeric lipid ball, 6 parts of aerosil；The polvmeric lipid ball is with poly- ammonia
Ester is skeleton, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, and the hydrophobic tail end of the phospholipid molecule of phospholipid layer is embedded in
Inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
C, batch mixing：By micropore micro mist and high molecular weight protein（Molecular weight is 60~200kD）, it is spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly；Wherein, by weight, 30 parts of micropore micro mist, macromolecule
Measure 28 parts of protein, 20 parts of spermaceti, 4 parts of allantoin, 14 parts of glycerine, 3 parts of vitamin E, 6 parts of vitamin B3, octyl dodecanol
5 parts of myristic acid fat, 4 parts of dimethyl siloxane, 3 parts of linoleic acid.
Embodiment 6
It is prepared with the following method from the bionical skin protection cosmetics of breathing：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, stirs and obtains the acid that mass concentration is 8% to being completely dissolved
Molten chitosan solution；By lysine hydrochloride with caustic alkali sodium hydroxide under argon atmosphere, 150 DEG C react 15h acquisition
In the crosslinked hyperbranched poly lysine of dendroid.
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, polymer fat is added
Matter ball, aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 30 parts of the chitosan solution of acid,
20 parts of hyperbranched poly lysine, 12 parts of polvmeric lipid ball, 8 parts of aerosil；The polvmeric lipid ball is with poly-
Urethane is skeleton, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, and the hydrophobic tail end of the phospholipid molecule of phospholipid layer is inlayed
Inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
C, batch mixing：By micropore micro mist and high molecular weight protein（Molecular weight is 60~200kD）, it is spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly；Wherein, by weight, 32 parts of micropore micro mist, macromolecule
Measure 30 parts of protein, 21 parts of spermaceti, 6 parts of allantoin, 16 parts of glycerine, vitamin E 5,4 parts of vitamin B3, octyl dodecanol meat
5 parts of myristic acid fat, 4 parts of dimethyl siloxane, 4 parts of linoleic acid.
Comparative example 1
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, stirs and obtains the acid that mass concentration is 8% to being completely dissolved
Molten chitosan solution；
B, micropore micro mist is prepared：By the molten chitosan solution of acid and polvmeric lipid ball, aerosil, it is spray-dried
To micropore micro mist；Wherein, by weight, molten 30 parts of the chitosan solution of acid, 12 parts of polvmeric lipid ball, aerosil
8 parts；The polvmeric lipid ball is using polyurethane as skeleton, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, phosphatide
The hydrophobic tail end of the phospholipid molecule of layer is embedded in inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
C, batch mixing：By micropore micro mist and high molecular weight protein（Molecular weight is 60~200kD）, it is spermaceti, allantoin, sweet
Oil, vitamin E, vitamin B3, octyl dodecanol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionization
Water, modulation become paste to get bionical skin protection cosmetics is breathed certainly；Wherein, by weight, 32 parts of micropore micro mist, macromolecule
Measure 30 parts of protein, 21 parts of spermaceti, 6 parts of allantoin, 16 parts of glycerine, vitamin E 5,4 parts of vitamin B3, octyl dodecanol meat
5 parts of myristic acid fat, 4 parts of dimethyl siloxane, 4 parts of linoleic acid.
Comparative example 1 using being in the crosslinked hyperbranched poly lysine of dendroid, does not influence micropore and from effect of breathing.
Test example 1
Experimental subjects：210 Irene volunteers are chosen, are randomly divided into 7 groups, every group of 30 volunteers：Respectively smear embodiment 1~
6 product and the product of comparative example 1.
Experimental method：Before volunteer gos out after face's cleaning, smears from bionical skin protection cosmetics is breathed, be carried out continuously 1
Week.After experiment, subject is asked to make evaluation of the cosmetics to skin elasticity and moistening effect, experimental result is shown in Table 1.
Evaluation criterion：A groups significantly improve skin elasticity and moistening effect；B groups have improvement skin elasticity and moistening effect,
But effect is limited；C groups do not improve skin elasticity and moistening effect substantially.
Table 1
Claims (10)
1. a kind of from the preparation method for breathing bionical skin protection cosmetics, which is characterized in that include the following steps：
A, it stocks up：Chitosan powder is scattered in aqueous acetic acid, is stirred to being completely dissolved, it is 5~10% to obtain mass concentration
The molten chitosan solution of acid；By lysine hydrochloride with caustic alkali under protective atmosphere, 140~160 DEG C react acquisition be in branch
The crosslinked hyperbranched poly lysine of shape；
B, micropore micro mist is prepared：The molten chitosan solution of acid is uniformly dispersed with hyperbranched poly lysine, addition polvmeric lipid ball,
Aerosil, spray drying obtain micropore micro mist；Wherein, by weight, molten 20~40 parts of the chitosan solution of acid surpasses
10~30 parts of branched polylysine, 5~15 parts of polvmeric lipid ball, 2~10 parts of aerosil；
C, batch mixing：By micropore micro mist and high molecular weight protein, spermaceti, allantoin, glycerine, vitamin E, vitamin B3, octyl
Lauryl alcohol myristic acid fat, dimethyl siloxane, linoleic acid mixing, are added deionized water, and modulation becomes paste to get breathing certainly
Bionical skin protection cosmetics；Wherein, by weight, 20~40 parts of micropore micro mist, 20~40 parts of high molecular weight protein, spermaceti 10
~30 parts, 1~10 part of allantoin, 10~20 parts of glycerine, 1~10 part of vitamin E, 1~10 part of vitamin B3, octyl dodecanol
1~10 part of myristic acid fat, 1~8 part of dimethyl siloxane, 2~6 parts of linoleic acid.
2. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：In step A, acid
The mass concentration of molten chitosan solution is 8%.
3. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：In step A, institute
It is argon gas atmosphere, neon atmosphere, helium atmosphere, Krypton atmosphere, xenon atmosphere or nitrogen atmosphere to state protective atmosphere.
4. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：In step A, institute
It is sodium hydroxide or potassium hydroxide to state caustic alkali.
5. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：In step A, instead
It is 150 DEG C to answer temperature, and the reaction time is 10~20h.
6. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：In step B, institute
It is using polyurethane as skeleton to state polvmeric lipid ball, and phospholipid layer is coated on the polvmeric lipid ball outside skeleton, the phosphorus of phospholipid layer
The hydrophobic tail end of fat molecule is embedded in inside polyurethane skeleton, and hydrophilic group is exposed to outer surface.
7. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：In step B, press
Parts by weight meter, molten 30 parts of the chitosan solution of acid, 20 parts of hyperbranched poly lysine, 12 parts of polvmeric lipid ball, silica airsetting
8 parts of glue.
8. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：It is high in step C
The molecular weight of molecular weight protein matter is 60~200kD.
9. according to claim 1 from the preparation method for breathing bionical skin protection cosmetics, it is characterised in that：In step C, press
Parts by weight meter, 32 parts of micropore micro mist, 30 parts of high molecular weight protein, 21 parts of spermaceti, 6 parts of allantoin, 16 parts of glycerine, vitamin E
5,4 parts of vitamin B3,5 parts of octyl dodecanol myristic acid fat, 4 parts of dimethyl siloxane, 4 parts of linoleic acid.
10. a kind of from the bionical skin protection cosmetics of breathing, it is characterised in that：It is breathed certainly using claim 1~9 any one of them
The preparation method of bionical skin protection cosmetics is prepared.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810965287.XA CN108743452A (en) | 2018-08-23 | 2018-08-23 | It is a kind of to breathe bionical skin protection cosmetics and preparation method certainly |
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| CN201810965287.XA CN108743452A (en) | 2018-08-23 | 2018-08-23 | It is a kind of to breathe bionical skin protection cosmetics and preparation method certainly |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020197669A1 (en) * | 2019-03-26 | 2020-10-01 | International Flavors & Fragrances Inc. | Use of polylysine dendrimers in the prevention and management of acne-prone skin and acneic skin |
| CN111728892A (en) * | 2020-08-14 | 2020-10-02 | 宋家豪 | Oil-control cosmetic cream for improving oily skin and preparation method thereof |
| WO2023247870A1 (en) | 2022-06-20 | 2023-12-28 | Belhadj Tahar Abdel Hafid | Cosmetic or dermatological composition comprising polylysine dendrimers and use thereof |
-
2018
- 2018-08-23 CN CN201810965287.XA patent/CN108743452A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020197669A1 (en) * | 2019-03-26 | 2020-10-01 | International Flavors & Fragrances Inc. | Use of polylysine dendrimers in the prevention and management of acne-prone skin and acneic skin |
| CN111728892A (en) * | 2020-08-14 | 2020-10-02 | 宋家豪 | Oil-control cosmetic cream for improving oily skin and preparation method thereof |
| WO2023247870A1 (en) | 2022-06-20 | 2023-12-28 | Belhadj Tahar Abdel Hafid | Cosmetic or dermatological composition comprising polylysine dendrimers and use thereof |
| WO2023247838A1 (en) * | 2022-06-20 | 2023-12-28 | Belhadj Tahar Abdel Hafid | Cosmetic or dermatological composition comprising polylysine dendrimers and use thereof |
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