CN106726765A - A kind of antiallergic moisturizing toner and preparation method thereof - Google Patents
A kind of antiallergic moisturizing toner and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
The invention belongs to cosmetic field, and in particular to a kind of antiallergic moisturizing toner and preparation method thereof.The invention provides a kind of antiallergic moisturizing toner, including following components and its percentage by weight:Sodium hyaluronate 5 10%, pyrrolidones hydroxy acid sodium 1 5%, cetanol 2 4%, butanediol 2 6%, Cer NS 6%, glycine betaine 4 8%, olive oil 1 2%, dipotassium glycyrrhizinate 0.5 1%, lycopene 0.5 1%, bisabolol 0.5 1%, methylisothiazolinone 0.1 0.5%, pH adjusting agent 0.1 0.5% and water 55 81.3%.The gentle non-stimulated, skin of antiallergic moisturizing toner that the present invention is provided is easy to absorb, and moistening effect is good, can for a long time keep the moisture of face skin, and antiallergic anti-inflammatory is applicable crowd wide.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of antiallergic moisturizing toner and preparation method thereof.
Background technology
With the improvement of people ' s living standards, the market demand of cosmetics will persistently rise, and numerous women are to shield
Skin cosmetics are extremely paid close attention to, and this is just for developing rapidly for beauty services industry has laid solid foundation.Cosmetics have become women
Necessity, the basic maintenance of skin is generally divided into cleaning, activity, moisturizing three major types, and moisturizing is then as human body needs intake daily
Vegetables meat supplements the nutrients equally, and moisturizing of the toner to skin is indispensable.Our skin usually compare it is greasy and
It is yellow dark, dry mostly because moisturizing is not enough.When the moisture that skin surface is cuticula reaches 15~25%, when aqueous sufficient, skin
Skin not only can soft smooth there is no microgroove, in feel also can full of elasticity.If our skin surface is sticky greasy, the inside is still
So lack moisture content wizened, drying regime does not change a bit.And because fat secretion is more, moisture content amount the reason for oily skin
Few, water oil amount loses equilibrium, so the maintenance of moisturizing, moisturizing to skin is extremely important.
Chinese patent application CN105662913A discloses a kind of toner of efficient moisture-retention, including following parts by weight
Composition:Lactic acid 0.05-0.3 parts, 5-17 parts of pyrrolidones hydroxy acid sodium, glycine betaine 2-10 parts, sorbierite 2.5-11 parts, alanine
0.5-4.5 parts, proline 0.5-5 parts, serine 0.5-4 parts, threonine 0.5-4.5 parts, arginine 0.5-5 parts, urea 3-12
Part, 0.5-5 parts of epithelical cell growth factor EGF, 0.05-0.5 parts and deionized water 925-945 parts of ceramide sodium.The invention
Can quickly be fully absorbed by the skin of human body and the effect with efficient moisture-retention, but its antiallergic antiseptic effect has much room for improvement.
Chinese patent application CN104546573A discloses a kind of new toner and preparation method thereof, and dispensing is:It is pure
Water, EDTA-Na2, allantoin, glycerine, propane diols, peppermint, amino acid humectant, rose, methylisothiazolinone.This is new
Type skin toner being capable of deep layer cleaning, effect of moisturizing, but its moisturizing effect has much room for improvement.
The content of the invention
In order to solve problems of the prior art, it is an object of the invention to provide a kind of antiallergic moisturizing toner and
Its preparation method.The gentle non-stimulated, skin of antiallergic moisturizing toner that the present invention is provided is easy to absorb, and moistening effect is good, can grow
Phase keeps the moisture of face skin, and antiallergic anti-inflammatory is applicable crowd wide.
The invention provides a kind of antiallergic moisturizing toner, including following components and its percentage by weight:
Sodium hyaluronate 5-10%, pyrrolidones hydroxy acid sodium 1-5%, cetanol 2-4%, butanediol 2-6%, Cer NS-
6%th, glycine betaine 4-8%, olive oil 1-2%, dipotassium glycyrrhizinate 0.5-1%, lycopene 0.5-1%, bisabolol 0.5-
1%th, methylisothiazolinone 0.1-0.5%, pH adjusting agent 0.1-0.5% and water 55-81.3%.
The reasonable science of compatibility of the present invention, each component interacts, and collaboration plays moisturizing water lock.
Further, described antiallergic moisturizing toner is made up of following components and its percentage by weight:
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine
6%th, olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, pH adjusting agent 0.3% and water 68.15%.
Further, the pH adjusting agent is by lactic acid and citric acid by weight 2:3 compositions.
Meanwhile, present invention provides a kind of preparation method of antiallergic moisturizing toner, comprise the following steps:
S1 heats water to 60-70 DEG C, and stirring adds cetanol, butanediol, glycine betaine and olive oil, stirs, and obtains
Solution A;
Step S1 resulting solutions A is cooled to 40-50 DEG C by S2, and stirring adds sodium hyaluronate, pyrrolidones hydroxy acid sodium, neural acyl
Amine, dipotassium glycyrrhizinate, lycopene and bisabolol, stir, and obtain solution B;
Step S2 resulting solutions B is cooled to 25 DEG C by S3, adds pH adjusting agent, regulation pH value to be eventually adding to 5.0-6.0
Methylisothiazolinone, stirring, obtains final product.
Further, the pH value in the step S3 is 5.5.
Sodium hyaluronate (C in antiallergic moisturizing toner prepared by the present invention28H44N2O23, CAS NO:9004-61-9) have and protect
It is wet, go wrinkle, absorbefacient effect;Pyrrolidones hydroxy acid sodium (C5H6NNaO3, CAS NO:28874-51-3) there is moisturizing, water suction
Effect;Ceramide (C34H66NO3R, CAS NO:100403-19-8) have and promote cell metabolism, the work of regulation moisture of skin
With;Dipotassium glycyrrhizinate (C42H60K2O16, CAS NO:68797-35-3) there is anti-inflammatory, antiallergy, skin whitening effect;Lycopene
(C40H56, CAS NO:502-65-8) there is anti-oxidant, the effect of regulation cell growth metabolism;Bisabolol (C15H26O, CAS
NO:515-69-5) there is anti-inflammatory, antianaphylactic effect.The reasonable science of compatibility of the present invention, each component interacts, and has cooperateed with increasing
Strong immunity, absorbs moisture, promotes the absorption of skin, antiallergy anti-inflammatory, so as to reach moisturizing, antianaphylactic effect.
Compared with prior art, the gentle non-stimulated, skin of antiallergic moisturizing toner that the present invention is provided is easy to absorb, moisturizing
Effect is good, can for a long time keep the moisture of face skin, and antiallergic anti-inflammatory is applicable crowd wide.
Specific embodiment
Below by specific embodiment, the present invention is described in more detail, and these embodiments are only used for the purpose of illustration,
It is not intended to limit protection scope of the present invention.
A kind of antiallergic moisturizing toner of embodiment 1
The antiallergic moisturizing toner is made up of following components and its percentage by weight:
Sodium hyaluronate 5%, pyrrolidones hydroxy acid sodium 1%, cetanol 2%, butanediol 2%, Cer NS %, glycine betaine
4%th, olive oil 1%, dipotassium glycyrrhizinate 0.5%, lycopene 0.5%, bisabolol 0.5%, methylisothiazolinone
0.1%th, lactic acid 0.04%, citric acid 0.06% and water 55%.
Preparation method:
S1 heats water to 65 DEG C, and stirring adds cetanol, butanediol, glycine betaine and olive oil, stirs, and obtains solution
A;
Step S1 resulting solutions A is cooled to 45 DEG C by S2, stirring add sodium hyaluronate, pyrrolidones hydroxy acid sodium, ceramide,
Dipotassium glycyrrhizinate, lycopene and bisabolol, stir, and obtain solution B;
Step S2 resulting solutions B is cooled to 25 DEG C by S3, adds lactic acid and citric acid, and regulation pH value is eventually adding to 5.5
Methylisothiazolinone, stirring, obtains final product.
A kind of antiallergic moisturizing toner of embodiment 2
The antiallergic moisturizing toner is made up of following components and its percentage by weight:
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine
6%th, olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, lactic acid 0.12%, citric acid 0.18% and water 68.15%.
Preparation method is similar to Example 1.
A kind of antiallergic moisturizing toner of embodiment 3
The antiallergic moisturizing toner is made up of following components and its percentage by weight:
Sodium hyaluronate 10%, pyrrolidones hydroxy acid sodium 5%, cetanol 4%, butanediol 6%, Cer AP %, glycine betaine
8%th, olive oil 2%, dipotassium glycyrrhizinate 1%, lycopene 1%, bisabolol 1%, methylisothiazolinone 0.5%, lactic acid
0.2%th, citric acid 0.3% and water 81.3%.
Preparation method is similar to Example 1.
A kind of antiallergic moisturizing toner of comparative example 1
The antiallergic moisturizing toner is made up of following components and its percentage by weight:
Pyrrolidones hydroxy acid sodium 10.5%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine 6%, olive oil
1.5%th, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone 0.3%, lactic acid
0.12%th, citric acid 0.18% and water 68.15%.
Preparation method is similar to Example 1.
Difference with embodiment 2 is to be not added with sodium hyaluronate, increased the consumption of pyrrolidones hydroxy acid sodium.
A kind of antiallergic moisturizing toner of comparative example 2
The antiallergic moisturizing toner is made up of following components and its percentage by weight:
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, sorbierite 3%, butanediol 4%, ceramide 4%, glycine betaine
6%th, olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, lactic acid 0.12%, citric acid 0.18% and water 68.15%.
Preparation method is similar to Example 1.
Difference with embodiment 2 is that cetanol is replaced with into sorbierite.
Test example one, safety evaluatio
1. test material:Antiallergic moisturizing toner prepared by embodiment 1-3.
2. subjects:60 people, women, 25-50 Sui, skin health, without skin disease allergies.
3. test method:
1) subject is randomly divided into 3 groups, every group of 20 people are denoted as embodiment 1-3 groups;
2) from qualified spot examination device, with closed patch experiment method, by tested material (antiallergic prepared by embodiment 1-3
Moisturizing toner) in spot examination device, external application special adhesive tape is covered on subject back to about 0.2-0.3mL drops, is removed after 24h tested
Thing, respectively remove after 0.5,6,12,24,48h observation dermoreaction, according to《Cosmetics health specification》Middle dermoreaction classification mark
Standard records its result.
4 result of the tests:
Result shows, after the antiallergic moisturizing toner that each group subject is prepared using embodiment 1-3,0.5,6,12,24,
48h observes dermoreaction, and skin has no adverse reaction, and illustrates that the antiallergic moisturizing toner of present invention preparation is safe and non-stimulating.
Test example two, moistening effect evaluation
1. test material:Antiallergic moisturizing toner prepared by embodiment 1-3 and comparative example 1-2.
2. subjects:100 people, women, 22-45 Sui, skin health, without skin disease allergies.
3. test method:
1) subject is randomly divided into 5 groups, every group of 20 people are denoted as embodiment 1-3 groups and comparative example 1-2 groups;
2) after subject's clear water washes one's face, forehead, left face, right face are tested respectively with Fes Kai Er SK-I skin moistures detectors
With the moisture of chin skin, and arithmetic mean of instantaneous value is taken;Subject uses above-mentioned antiallergic moisturizing toner, and uniform application is in face
Portion, gently pats, and with the skin moisture content of test forehead, left face, right face and chin same location after 15min, and takes arithmetic
Average value, tests one time again after 12h, takes arithmetic mean of instantaneous value.
4. result of the test:Skin moisture content test result is shown in Table 1.
The skin moisture content test result of table 1
As shown in Table 1, the antiallergic moisturizing toner moisturizing of present invention preparation, water lock effect are preferable.And prepared by comparative example 1-2
The moisturizing of antiallergic moisturizing toner, water lock effect it is poorer than the effect of antiallergic moisturizing toner prepared by embodiment 1-3, illustrate this
The reasonable science of invention compatibility, each component is interacted, and the effect of moisturizing, water lock is played in collaboration, reaches the effect of long-term moisturizing, skin
Skin water profit is vibrant.
Claims (5)
1. a kind of antiallergic moisturizing toner, it is characterised in that including following components and its percentage by weight:
It is sodium hyaluronate 5-10%, pyrrolidones hydroxy acid sodium 1-5%, cetanol 2-4%, butanediol 2-6%, Cer NS -6%, sweet
Dish alkali 4-8%, olive oil 1-2%, dipotassium glycyrrhizinate 0.5-1%, lycopene 0.5-1%, bisabolol 0.5-1%, methyl
OIT 0.1-0.5%, pH adjusting agent 0.1-0.5% and water 55-81.3%.
2. antiallergic moisturizing toner as claimed in claim 1, it is characterised in that by following components and its percentage by weight group
Into:
Sodium hyaluronate 7.5%, pyrrolidones hydroxy acid sodium 3%, cetanol 3%, butanediol 4%, ceramide 4%, glycine betaine 6%,
Olive oil 1.5%, dipotassium glycyrrhizinate 0.75%, lycopene 0.75%, bisabolol 0.75%, methylisothiazolinone
0.3%th, pH adjusting agent 0.3% and water 68.15%.
3. antiallergic moisturizing toner as claimed in claim 1 or 2, it is characterised in that the pH adjusting agent is by lactic acid and lemon
Acid is by weight 2:3 compositions.
4. the preparation method of the antiallergic moisturizing toner as described in claim 1-3 is any, it is characterised in that including following step
Suddenly:
S1 heats water to 60-70 DEG C, and stirring adds cetanol, butanediol, glycine betaine and olive oil, stirs, and obtains solution
A;
Step S1 resulting solutions A is cooled to 40-50 DEG C by S2, stirring add sodium hyaluronate, pyrrolidones hydroxy acid sodium, ceramide,
Dipotassium glycyrrhizinate, lycopene and bisabolol, stir, and obtain solution B;
Step S2 resulting solutions B is cooled to 25 DEG C by S3, adds pH adjusting agent, regulation pH value to be eventually adding methyl to 5.0-6.0
OIT, stirring, obtains final product.
5. the preparation method of antiallergic moisturizing toner as claimed in claim 4, it is characterised in that the pH value in the step S3
It is 5.5.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110613656A (en) * | 2019-11-13 | 2019-12-27 | 渭南师范学院 | Brightening toner |
CN115607473A (en) * | 2022-10-24 | 2023-01-17 | 周嘉奇 | Anti-allergy soothing toner and preparation method thereof |
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CN104546594A (en) * | 2014-12-11 | 2015-04-29 | 罗生芳 | Moisturizing toner and preparation method thereof |
CN105213252A (en) * | 2015-09-25 | 2016-01-06 | 斐丝肌(上海)商贸有限公司 | A kind ofly lock essence of water moisture-keeping efficacy and preparation method thereof |
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2016
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CN103735458A (en) * | 2013-12-25 | 2014-04-23 | 珠海市时代经典化妆品有限公司 | Novel anti-allergy repairing composition for skin |
CN104546594A (en) * | 2014-12-11 | 2015-04-29 | 罗生芳 | Moisturizing toner and preparation method thereof |
CN105213252A (en) * | 2015-09-25 | 2016-01-06 | 斐丝肌(上海)商贸有限公司 | A kind ofly lock essence of water moisture-keeping efficacy and preparation method thereof |
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Title |
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吕百龄: "《实用工业助剂全书》", 31 August 2001, 化学工业出版社 * |
江松敏: "《营养健康与疾病预防》", 31 March 2015, 军事医学科学出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110613656A (en) * | 2019-11-13 | 2019-12-27 | 渭南师范学院 | Brightening toner |
CN115607473A (en) * | 2022-10-24 | 2023-01-17 | 周嘉奇 | Anti-allergy soothing toner and preparation method thereof |
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