CN103735458A - Novel anti-allergy repairing composition for skin - Google Patents
Novel anti-allergy repairing composition for skin Download PDFInfo
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- CN103735458A CN103735458A CN201310733808.6A CN201310733808A CN103735458A CN 103735458 A CN103735458 A CN 103735458A CN 201310733808 A CN201310733808 A CN 201310733808A CN 103735458 A CN103735458 A CN 103735458A
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Abstract
The invention discloses a novel anti-allergy repairing composition for skin. The anti-allergy repairing composition comprises the following components by weight percent: 5%-12% of moisturizing agent, 0.1%-3.0% of thickener, 1%-4% of skin repairing agent, 0.1%-1.5% of preservative, and the balance of water. The invention also discloses a preparation method of the skin repairing agent. The anti-allergy repairing composition for skin can be prepared into cream or water aqua, can be directly smeared at the infected part and has no toxicity or harm to human skin. The skin repairing composite component has strong effects of clearing heat and detoxifying, being anti-allergy, repairing skin, diminishing inflammation and astringing; other auxiliary additive components are selected from the moisturizing agent, preservative and thickener and the like which can keep the skin tender and smooth and moisturize the skin and are mild and non-irritant to skin. The anti-allergy repairing composition is convenient to use, achieves the purposes of moisturizing, diminishing inflammation and relieving itching and repairing damaged skin, and is applicable to sensitive skin and skin allergy, pruritus, desquamation, red and swollen skin and couperose skin that are caused by misuse of cosmetics.
Description
Technical field
The present invention relates to the novel antiallergic remediation composition capable of a kind of skin, belong to cosmetic formulations technical field.
Background technology
Along with the progress of modern science and technology, the raising of people's living standard, people are more and more stronger for the pursuit of healthy and beautiful appearance, municipal pollution, industrial waste gas, ultraviolet radiation, the use of defective cosmetics and the various beautiful abuse for the treatment of instrument are also endangering our skin day by day, according to statistics in 2004, show, contact dermatitis is the most common in six large class cosmetic dermatosises, and its sickness rate accounts for 82.6% of cosmetic dermatosis total incidence.Allergy has seemed pursuing like the shadow following the person bad dream on healthy beautiful road into people.Treat the diseases such as the multiple erythema of sensitivity or allergic skin, pimple, desquamation, pruritus, need to use sugared skin parahormone; If prolonged and repeated use hormone, there will be atrophoderma, the symptoms such as telangiectasis, purpura, acne pigment anomaly, photosensitivity, the women who likes to be beautiful to the modern times brings endless worry, and hormone therapy easily produces dependency.How to find the method for alleviating safely and effectively allergic symptom, become the problem of people's growing interest.Cosmetic industry is gradually towards the future development of advocating green, back to nature in recent years.But most plants antiallergic additive curative effect is all not satisfactory, the natural antiallergic active substance that exploitation contains unique effects, and added in cosmetics, develop natural safe and effective antiallergic product, become cosmetic industry and developed one of most active theme.
The present invention learns principle based on differential diagnosis in tcm, for sensitivity or the multiple dermatitis of damaged skin, impose antiallergic anti-inflammatory medicine combined extracts, be aided with other component raw material simultaneously, make contained effective ingredient in formula there is heat-clearing and toxic substances removing, antiallergic reparation, convergence antiinflammatory, increase the effects such as skin elasticity and gloss.This skin antiallergic reparation combination can directly act on skin damage position, compared to oral or injectivity antiallergic medicine, have no side effect, effective, easy to use, can alleviate rapidly the congestion and swelling pain causing due to skin allergy, solved the vast women of liking to be beautiful in cosmetics use procedure, the frequent puzzlement producing of skin allergy phenomenon, and the larger skin lesion problem that adopts hormone therapy allergic skin inflammation to cause patient.Both be suitable for alleviation and the prevention of sensitive skin for allergic symptom, be suitable for again the allergic symptom causing due to cosmetics improper use.
Summary of the invention
The object of the present invention is to provide a kind of directly act on skin sensitivity position, pure natural extract, have no side effect, effective simple to operate; Alleviating the skin that compacts in allergic symptom, strengthen skin resistance; Light, the moderate allergic symptom that to solve cosmetics improper use, cause, meet people for skin care, gentle antiallergic, safe and effective three kinds of demands, avoids the injury of using hormone antiallergic to bring to skin.
The present invention realizes above-mentioned purpose by following technical solution:
A kind of novel skin antiallergic maintenance compositions, is characterized in that: it is to be made by the raw material of following percentage by weight:
Preferably, it also comprises the Defensil that percentage by weight is 0.1%-2%.
Wherein, Defensil is the plant antisensitizer that RAHN COSMETICS company produces.
Preferably, described wetting agent is: one or more in glycerol, hyaluronate sodium, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate (MG60), propylene glycol, butanediol, trimethyl glycine (betanin).
Preferably, the addition of described wetting agent is: glycerol 4%～8%, hyaluronate sodium 0.03%～0.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate (MG60) 0.1%～0.5%, propylene glycol 4%～8%, butanediol 4%～8%, trimethyl glycine 1%～7%.
Preferably, described wetting agent is: glycerol 4%～8%, hyaluronate sodium 0.03%～0.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate (MG60) 0.1%～0.5%.
Preferably, described thickening agent be carbomer, acrylate-13(and) polyisobutylene (and with) polysorbate-20(SEPIPLUS 400), 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers (SEPINOV EMT10), polyacrylamide/laureth-7/C13-14 isoparaffin (GEL305), sodium polyacrylate (with) caprylic/capric triglyceride (with) Dormant oils (with) three (PPG-3 Semen Myristicae alcohol ethers), citrate (with) the smooth laurate of Pyrusussuriensis (with) tridecyl alcohol polyethers-6(RMA-IS) in one or more.
Preferably, described antiseptic is one or more in Methylisothiazolinone, DMDM Hydantoin, phenoxyethanol, BIT.
Preferably, described skin-rehabilitating agent is the alcohol extract of Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis and the mixture of red wine polyphenols.More preferably, described skin-rehabilitating agent is the grape procyanidins of Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis equal portions blend alcohol extract and equal portions.
Preferably, main Effect raw material is Defensil and skin-rehabilitating agent combination.
Preferably, the preparation method of described antiallergic renovation agent is: get raw material of Chinese medicine Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis, getting identical deal cleans, dry, after pulverizing blend, with butanediol, extract, after filtering, mixes with the red wine polyphenols of equal portions, then add above-mentioned other raw materials and deionized water, according to manufacturing process, be prepared into cream frost, emulsion, elite, water and directly smear.Further preferably, described butanediol extracting method is: with 50-70 ℃ of constant temperature stirring 2-4 hour of 1,3 butylene glycol, standing 7-9 hour, gets supernatant liquid filtering.
The preparation method of a kind of novel skin antiallergic of the present invention maintenance compositions is: raw material is divided into groups according to thermostability, and heating for dissolving, is cooled to 38 ℃ or add thermo-labile active component below, stirs and can obtain product of the present invention.
Prescription dissects:
The present invention learns principle based on differential diagnosis in tcm, for sensitivity or the multiple dermatitis of damaged skin, impose antiallergic anti-inflammatory medicine combined extracts, be aided with other component raw material simultaneously, make preparation there is heat-clearing and toxic substances removing, anti-inflammation and sterilization, skin resistance is repaired, is strengthened in convergence, the effects such as the elasticity of raising skin and gloss.Wherein Radix Sophorae Flavescentis heat clearing and damp drying, has the effect of good bactericidal antiphlogistic.Herba Plantaginis, is China's Chinese medicine, has clearing away heat and promoting diuresis treating stranguria, eliminate the phlegm, and removing heat from blood, the effect of removing toxic substances.Herba Silybi mariani seed contains flavonols compound, and nature and flavor hardship, cool has heat-clearing and toxic substances removing, protects the liver, the effect such as function of gallbladder promoting.Grape procyanidins, claims again grape seed procyanidine, is a kind of plant polyphenol kind active substance, and quantity research shows greatly, and grape procyanidins has antioxidation, removes the biologic activity such as free radical, antimicrobial, radioprotective, the effects such as antiviral, anti-inflammatory.Radix Sophorae Flavescentis is cold in nature, has heat clearing and damp drying, and Bergamot Mint Extract is dredged and restrains pore, removes the effects such as skin endotoxin impurity.Abundant herbal nutrition, promotes growth and the reparation of damaged blood vessels neurocyte, recovers subcutaneous capillary cell viability, plays the effect of beauty and skin care.
The wetting agent that the present invention preferably adopts is glycerol, propylene glycol, butanediol, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate (MG60), betanin and hyaluronate sodium.
Glycerol that is to say glycerol (Glycerin).It is the dense thick liquid of a kind of colourless, odorless, pleasantly sweet, clear, is internationally recognized high-performance wetting agent, and its safety obtains the whole world and generally admits, and is widely used in the industries such as medicine, food, cosmetics.Glycerol has very strong hygroscopicity, can form thin film at skin surface, can completely cut off air and prevent moisture evaporation, makes not frost bitten of skin, is not subject to the infringement of dust etc., thereby makes skin keep softness and high resilience.
1,3 butylene glycol is a kind of no color or smell thick liquid, has good hygroscopicity.Skin and eyes are had no stimulation, to oral mucosa nonirritant, also harmless, be usually used in skin care item, play moisture-keeping function.1,3 butylene glycol also has antibacterial action, its minimum inhibitory concentration to each quasi-microorganism: the mass fraction of streptococcus pneumoniae I type, streptococcus C type and A type is 5%, and staphylococcic mass fraction is 15%.
MG60(Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate), a by the born carbohydrate syrup wetting agent of starch derivatives, it and glycerol have unique assosting effect to the moisture equilibrium at dry side of optimizing skin, glycerol can improve dry skin, and MG60 can keep the pliability of skin, in addition, it can alleviate sensitive skin due to stimulation and pruritus that the potent surfactant of contact produces, is particularly useful for aiming in the product of sensitive skin formula.
Betanin is the natural molecule that occurring in nature exists, and it is present in shellfish and plant, is the product of the Radix Betae course of processing, and in molasses, content reaches 8%.Because trimethyl glycine contained in betanin has very the polar end molecule in conjunction with hydrogen atom by force, so, it can with the strong combination of the molecule of water and similar water, thereby make it there is unique physicochemical property, in skin care item, application makes skinfeel smooth as thick in silk.Because it has pH cushioning effect, therefore, in cosmetics, the zest of the high moisture-keeping function of trimethyl glycine and reduction skin is very effective.
Hyaluronic acid is ubiquitous important component in intercellular matrix, and it is filled in the space (as cells such as skin, cartilage, muscle and muscle) between the cell of various tissues.The function of hyaluronan molecule most important biology of aspect is the ability that keeps moisture in intercellular substance, it keeps the energy force rate of moisture, and other are any natural or synthetic polymer is strong, and it is 98% moisture that 2% pure hyaluronic acid aqueous solution can firmly keep mass fraction.When hyaluronic acid solution is applied in skin surface, can form viscoelastic thin film, these thin film have water-retaining property as the hyaluronic acid in the intercellular matrix of skin conjunctive tissue, and without vestiges or greasy feeling, and have softness, level and smooth and lubricious skinfeel.
Preferably carbomer of thickening agent of the present invention, acrylate-13(and) polyisobutylene (and with) polysorbate-20(SEPIPLUS 400), 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers (SEPINOV EMT10), polyacrylamide/laureth-7/C13-14 isoparaffin (GEL305), sodium polyacrylate (with) caprylic/capric triglyceride (with) Dormant oils (with) three (PPG-3 Semen Myristicae alcohol ether) citrate (with) the smooth laurate of Pyrusussuriensis (with) tridecyl alcohol polyethers-6(RMA-IS) in one or more.
Antiseptic of the present invention is one or more in Methylisothiazolinone, DMDM Hydantoin, phenoxyethanol, BIT preferably.
After above-mentioned all components compatibility, have the collaborative effect of heat clearing away, removing toxic substances, removing heat from blood, can eliminate scytitis, convergence is moistened, and gloss skin is repaired damaged part, recovers elasticity and the gloss of skin.Can fall apart clearly carbuncle, clean skin is hyperchromic, can nourish again protection skin, is applicable to the skin types such as the caused skin allergy of cosmetics improper use, pruritus, desquamation, redness, red blood streak.
In the above-mentioned raw material components of the present invention, property feature and the effect of the raw material of Chinese medicine of skin maintenance are as follows:
Herba Plantaginis, Herba Plantaginis has another name called wheel dish, it is China's Chinese medicine, use (< < Chinese Pharmacopoeia > > version in 2010 is recorded) with a long history, it is treating stranguria that Herba Plantaginis has clearing away heat and promoting diuresis, eliminate the phlegm, and removing heat from blood, the effect of removing toxic substances, for the puckery pain of pyretic stranguria, edema oliguria, diarrhea due to summer heat and dampness, carbuncle sore tumefacting virus.Modern scientific research shows that Herba Plantaginis effective ingredient mainly comprises the various trace elements such as apigenin, luteolin, Homoplantaginin, phenethyl alcohol glycoside, cyclenes ether mushroom, triterpene and sterol, Ca, Mn, Zn, Fe, Cu, prove after deliberation, Herba Plantaginis alcohol extract has the effects such as the damaged cell of reparation and antiphlogistic antibacterial.
Radix Sophorae Flavescentis, cold in nature, there is heat clearing and damp drying, the effect of sterilization, Radix Sophorae Flavescentis is bathed can remove damp-heat in lower-JIAO, and sterilizing and itch-relieving, skin pruritus is had to good mitigation, the matrine that its spy contains can Bergamot Mint Extract, dredges and restrains pore, removes skin endotoxin impurity, promote growth and the reparation of damaged blood vessels neurocyte, recover subcutaneous capillary cell viability, reproduction skin compacts fine and smooth, plays the effect of beauty and skin care.Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus in addition; Radix Sophorae Flavescentis water logging agent has inhibitory action to trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly budlet spore tinea bacterium difficult to understand etc.
Grape procyanidins, claims again grape seed procyanidine, is a kind of plant polyphenol kind active substance, can be water-soluble, be soluble in the organic solvents such as methanol, ethanol.It is extensively present in Semen Vitis viniferae, Pericarpium Vitis viniferae and fruit juice, large quantity research shows, grape procyanidins has antioxidation, removes the biologic activity such as free radical, antimicrobial, radioprotective, is medically having very wide application prospect, and it has the effects such as anticancer, resisting hypertension, antiviral, anti-inflammatory.
Beneficial effect of the present invention is:
Skin antiallergic maintenance compositions of the present invention can be made into cream and water preparation, is directly applied in affected part, nontoxic to human body skin.Skin repair composite parts wherein has the effects such as very strong heat-clearing and toxic substances removing, antiallergic reparation, antiinflammatory convergence; Other are assisted a ruler in governing a country and add component and all select and can make skin tender, smooth, moist and to the non-stimulated wetting agent of skin gentleness, antiseptic, thickening agent etc., easy to use, reach the object of moisturizing, anti-inflammatory anti-itch, reparation damaged skin.Skin antiallergic maintenance compositions of the present invention is applicable to the phenomenons such as skin allergy that sensitive skin and cosmetics improper use cause, pruritus, desquamation, redness, red blood streak.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described, and the percentage ratio in embodiment is all weight percentage.
Embodiment 1
Preparation is containing the skin antiallergic maintenance frost of 2% skin-rehabilitating agent
1, skin-rehabilitating agent preparation: get Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis raw material of Chinese medicine, clean, dry, get after identical deal is pulverized blend and use 60 ℃ of constant temperature of 1,3 butylene glycol to stir 4 hours, standing 8 hours, get supernatant liquid filtering, mix with the red wine polyphenols of equal portions, obtain skin-rehabilitating agent of the present invention.
2, contain the preparation method of the skin antiallergic maintenance frost of 2% skin-rehabilitating agent
The preparation technology of this skin antiallergic maintenance combination is as follows:
(1) first by the material name in above table and raw material weight, take each raw material;
(2) by A four kinds of heating raw materials to 85 ℃ mutually, be stirred to completely and dissolve;
(3) stir and be cooled to 50 ℃～60 ℃, B is added to, stir and high speed homogenization 3min, stir and be cooled to 45 ℃, add C phase, stir, be cooled to 38 ℃ and can obtain target product.
Embodiment 2
Prepare the skin antiallergic maintenance frost of the defensil that contains 0.5%
1, containing the preparation method of the skin antiallergic maintenance frost of 0.5% defensil
The preparation technology of this skin antiallergic maintenance combination is as follows:
(1) first by the material name in above table and raw material weight, take each raw material;
(2) by A four kinds of heating raw materials to 85 ℃ mutually, be stirred to completely and dissolve;
(3) stir and be cooled to 50 ℃～60 ℃, B is added to, stir and high speed homogenization 3min, stir and be cooled to 45 ℃, add C phase, stir, be cooled to 38 ℃ and can obtain target product.
Embodiment 3
Preparation is containing the skin antiallergic maintenance frost of the skin-rehabilitating agent of 0.5%defensil and 2%
1, skin-rehabilitating agent preparation: get Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis raw material of Chinese medicine, clean, dry, get after identical deal is pulverized blend and use 60 ℃ of constant temperature of 1,3 butylene glycol to stir 4 hours, standing 8 hours, get supernatant liquid filtering, mix with the red wine polyphenols of equal portions, obtain skin-rehabilitating agent of the present invention.
2, contain the preparation method of the skin antiallergic maintenance frost of 2% skin-rehabilitating agent
The preparation technology of this skin antiallergic maintenance combination is as follows:
(1) first by the material name in above table and raw material weight, take each raw material;
(2) by A four kinds of heating raw materials to 85 ℃ mutually, be stirred to completely and dissolve;
(3) stir and be cooled to 50 ℃～60 ℃, B is added to, stir and high speed homogenization 3min, stir and be cooled to 45 ℃, add C phase, stir, be cooled to 38 ℃ and can obtain target product.
Embodiment 4
1, skin-rehabilitating agent preparation: get Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis raw material of Chinese medicine, clean, dry, get after identical deal is pulverized blend and use 50 ℃ of constant temperature of 1,3 butylene glycol to stir 2 hours, standing 7 hours, get supernatant liquid filtering, mix with the red wine polyphenols of equal portions, obtain skin-rehabilitating agent of the present invention.
2, the preparation of skin antiallergic remediation composition capable
The preparation technology of this skin antiallergic maintenance combination is as follows:
(1) first by the material name in above table and raw material weight, take each raw material.
(2) by A three kinds of heating raw materials to 85 ℃ mutually, be stirred to completely and dissolve.
(3) stir and be cooled to 50 ℃～60 ℃, B is added to, stir and high speed homogenization 3min.Stirring is cooled to 45 ℃, adds C phase, stirs, and is cooled to 38 ℃ and can obtains product of the present invention.
(4) after subpackage, be finished product.
This skin antiallergic maintenance compositions finished product is elite state, through the heat-resisting cold-resistant qualified stability that experiment showed.
Embodiment 5
1, skin-rehabilitating agent preparation: get Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis raw material of Chinese medicine, clean, dry, get after identical deal is pulverized blend and use 60 ℃ of constant temperature of 1,3 butylene glycol to stir 3 hours, standing 8 hours, get supernatant liquid filtering, mix with the red wine polyphenols of equal portions, obtain skin-rehabilitating agent of the present invention.
2, the preparation of skin antiallergic maintenance compositions
The preparation technology of this skin antiallergic maintenance combination is as follows:
(1) first by the material name in above table and raw material weight, take each raw material.
(2) by A five kinds of heating raw materials to 85 ℃ mutually, be stirred to completely and dissolve.High speed homogenization 3min.Stirring is cooled to 45 ℃, adds C phase, stirs, and is cooled to 38 ℃ and can obtains product of the present invention.
(3) after subpackage, be finished product.
This skin antiallergic maintenance compositions finished product is cream frost state, through the heat-resisting cold-resistant qualified stability that experiment showed.
Embodiment 6
1, skin-rehabilitating agent preparation: get Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis raw material of Chinese medicine, clean, dry, get after identical deal is pulverized blend and use 70 ℃ of constant temperature of 1,3 butylene glycol to stir 4 hours, standing 9 hours, get supernatant liquid filtering, mix with the red wine polyphenols of equal portions, obtain skin-rehabilitating agent of the present invention.
2, the preparation of skin antiallergic maintenance compositions
The preparation technology of this skin antiallergic maintenance combination is as follows:
(1) first by the material name in above table and raw material weight, take each raw material.
(2) by A five kinds of heating raw materials to 85 ℃ mutually, be stirred to completely and dissolve.
(3) stir and be cooled to 45 ℃, add C phase, stir, be cooled to 38 ℃ and can obtain product of the present invention.
(4) after subpackage, be finished product.
This skin antiallergic maintenance compositions is the water state of denseness slightly, through the heat-resisting cold-resistant qualified stability that experiment showed.
Embodiment 7
For showing that the present invention alleviates the effect of skin allergy symptom or allergic inflammation, the present invention is through observation and record to 270 person on probations, and its data are as follows:
(1) 270 person on probation's age is between 20～35 years old, the order growing from weak to strong by its skin sensitivity degree is divided into three kinds of skin types them respectively, can there is once in a while the phenomenons such as the slight flushing of face, scorching hot, pruritus in 108 triers wherein in daily skin nursing process, is A type skin; Can often there is flush, pruritus, scorching hot, dry, desquamation phenomenon in 72 triers, be Type B skin when routine use skin care item; 90 triers, for occurring the symptoms such as serious flush, pruritus, pain, dry desquamation, are C type skin.Above-mentioned each sensitive skin type is equally divided into six groups, and I group is used the skin-rehabilitating agent product that adds 2%, according to the prepared product of embodiment 1; II group is used the product of the defensil that adds 0.5%, according to the prepared product of embodiment 2; The product of the skin-rehabilitating agent of III group use interpolation 2.0% and 0.5% defensil, according to the prepared product of embodiment 3; IV group is used the skin-rehabilitating agent of interpolation 1.5% and 1.0% defensil product, according to the prepared product of embodiment 4; V group is used the skin-rehabilitating agent of interpolation 4.0% and 2.0% defensil product, according to the prepared product of embodiment 5; VI is used the skin-rehabilitating agent of interpolation 1.0% and 0.1% defensil product, according to the prepared product of embodiment 6.(composition of the product that I, II, III are used is except skin-rehabilitating agent is different with defensil, and other concrete constituents and preparation technology are all identical.）
(2) using method: get finished product of the present invention, clean affected part, sooner or later respectively once, continues to use month.
(3) effect criterion:
Recovery from illness or successful: subjective symptoms all disappears or most of disappearance;
Effective: subjective symptoms alleviates or partial symptoms disappears;
Invalid: subjective symptoms is without change, or change not obvious.
(4) result on trial is as follows:
The impact of the skin-rehabilitating agent product of table 1 I group use interpolation 2.0% on skin
| Skin type | Number | Recovery from illness or effect are remarkable | Effectively | Invalid | Obvious effective rate |
| A type | 18 | 11 | 7 | 0 | 61.1% |
| Type B | 12 | 8 | 3 | 1 | 66.7% |
| C type | 15 | 2 | 12 | 1 | 13.3% |
The impact of the defensil product of table 2 II group use interpolation 0.5% on skin
| Skin type | Number | Recovery from illness or effect are remarkable | Effectively | Invalid | Obvious effective rate |
| ? | ? | 2 | 15 | ? | 11.1:o |
| Type B | 12 | 3 | 8 | 1 | 25.0% |
| C type | 15 | 8 | 7 | 0 | 53.3% |
The skin-rehabilitating agent of table 3 III group use interpolation 2.0% and the impact of 0.5% defensil product on skin
| Skin type | Number | Recovery from illness or effect are remarkable | Effectively | Invalid | Obvious effective rate |
| A type | 18 | 16 | 2 | 0 | 88.9% |
| Type B | 12 | 11 | 1 | 0 | 91.7% |
| C type | 15 | 11 | 3 | 1 | 73.3% |
The skin-rehabilitating agent of table 4 IV group use interpolation 1.5% and the impact of 1.0% defensil product on skin
| Skin type | Number | Recovery from illness or effect are remarkable | Effectively | Invalid | Obvious effective rate |
| A type | 18 | 17 | 1 | 0 | 94.4% |
| Type B | 12 | 10 | 2 | 0 | 83.3% |
| C type | 15 | 13 | 1 | 1 | 86.6% |
The skin-rehabilitating agent of table 5 V group use interpolation 4.0% and the impact of 2.0% defensil product on skin
| Skin type | Number | Recovery from illness or effect are remarkable | Effectively | Invalid | Obvious effective rate |
| A type | 18 | 17 | 0 | 1 | 94.4% |
| Type B | 12 | 11 | 1 | 0 | 91.6% |
| C type | 15 | 14 | 1 | 0 | 93.3% |
The skin-rehabilitating agent of table 6 VI group use interpolation 1.0% and the impact of 0.1% defensil product on skin
| Skin type | Number | Recovery from illness or effect are remarkable | Effectively | Invalid | Obvious effective rate |
| A type | 18 | 15 | 2 | 1 | 83.3% |
| Type B | 12 | 9 | 3 | 0 | 75.0% |
| C type | 15 | 11 | 3 | 1 | 73.3% |
Illustrate: obvious effective rate is counted the percentage ratio of sum for fully recovering or the significant number of effect in person on probation, accounting for this kind of skin type human.
From shown in upper table, can find out, the product that adds skin-rehabilitating agent in table 1 all exceedes 60% to the obvious effective rate of A, Type B skin.To the obvious effective rate of C type skin, be 13.3%, as can be seen from the above results, erubescence, pruritus, desquamation that the present invention causes because skin care item are used prevention, the phenomenon successful such as dry, alignment degree allergy also has certain effect.
In table 2, adding 0.5% defensil product is 53.3% to the obvious effective rate of C type skin, to the obvious effective rate of A, Type B skin lower than 30%, as can be seen from the above results, add 0.5% defensil product alignment degree anaphylactic type effect remarkable, a little less than using the erubescence that causes, pruritus, desquamation, the phenomenon effect such as dry to add the product of skin-rehabilitating agent to prevention skin care item.
In table 3, using the skin-rehabilitating agent of interpolation 2.0% and 0.5% defensil product is 73.3% to the obvious effective rate of C type skin, obvious effective rate to A, Type B skin is respectively 88.9%, 91.7%, in contrast table 1, table 2, data can be found out, use and add 2.0% skin-rehabilitating agent and 0.5% defensil product has remarkable lifting to the obvious effective rate of A, B, C three types skin, to prevention and alleviate erubescence, pruritus, desquamation, the phenomenon effect such as dry is remarkable.
In table 4, using the skin-rehabilitating agent of interpolation 1.5% and 1.0% defensil product is 86.6% to the obvious effective rate of C type skin, obvious effective rate to A, Type B skin is respectively 94.4%, 83.3%, in contrast table 1, table 2, data can be found out, use and add 1.5% skin-rehabilitating agent and 1.0% defensil product has remarkable lifting to the obvious effective rate of A, B, C three types skin, to prevention and alleviate erubescence, pruritus, desquamation, the phenomenon effect such as dry is remarkable.
In table 5, using the skin-rehabilitating agent of interpolation 4.0% and 2.0% defensil product is 93.3% to the obvious effective rate of C type skin, obvious effective rate to A, Type B skin is respectively 94.4%, 91.6%, in contrast table 1, table 2, data can be found out, use and add 4.0% skin-rehabilitating agent and 2.0% defensil product product has remarkable lifting to the obvious effective rate of A, B, C three types skin, to prevention and alleviate erubescence, pruritus, desquamation, the phenomenon effect such as dry is remarkable.
In table 6, using the skin-rehabilitating agent of interpolation 1.0% and 0.1% defensil product is 73.3% to the obvious effective rate of C type skin, obvious effective rate to A, Type B skin is respectively 83.3%, 75.0%, in contrast table 1, table 2, data can be found out, use and add 1.0% skin-rehabilitating agent and 0.1% defensil product has remarkable lifting to the obvious effective rate of A, B, C three types skin, to prevention and alleviate erubescence, pruritus, desquamation, the phenomenon effect such as dry is remarkable.
Conclusion 1: skin-rehabilitating agent of the present invention is to prevention and alleviate erubescence, pruritus, desquamation, the phenomenon effect such as dry is remarkable.
Conclusion 2: containing the obvious effective rate of the skin antiallergic maintenance frost of 0.5%defensil and 2% skin-rehabilitating agent far away higher than the two independent result of use, and effect when being far longer than the two and using separately obvious effective rate add and.
The composite effect of conclusion 3:defensil and skin-rehabilitating agent is far longer than the two and uses separately, has synergism.
Exemplary:
Zhuhai, Wang, female, 26 years old, owing to using skin care item to cause erubescence, swelling, pruritus, pain, desquamation.Use this product is erubescence, pruritus, transference cure after three days, and desquamation phenomenon alleviates, and after 8 days, desquamation symptom obviously alleviates, recovery from illness afterwards in 15 days.
Claims (10)
1. a novel skin antiallergic maintenance compositions, is characterized in that: by weight percentage, it comprises:
Wetting agent 5.0% ~ 12.0%
Thickening agent 0.1% ~ 3.0%
Skin-rehabilitating agent 1.0% ~ 4.0%
Antiseptic 0.1% ~ 1.5%
Water surplus.
2. a kind of novel skin antiallergic maintenance compositions according to claim 1, is characterized in that: it also comprises the Defensil that percentage by weight is 0.1%-2%.
3. a kind of novel skin antiallergic maintenance compositions according to claim 1, is characterized in that: described wetting agent is: one or more in glycerol, hyaluronate sodium, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate, propylene glycol, butanediol, betanin.
4. a kind of novel skin antiallergic maintenance compositions according to claim 2, it is characterized in that: the addition of described wetting agent is: glycerol 4% ~ 8%, hyaluronate sodium 0.03% ~ 0.5%, Fructus Hordei Germinatus oligose glucoside/hydrogenated starch hydrolysate 0.1% ~ 0.5%, propylene glycol 4% ~ 8%, butanediol 4% ~ 8%, betanin 1% ~ 7%.
5. a kind of novel skin antiallergic maintenance compositions according to claim 1, is characterized in that: described thickening agent be carbomer, acrylate-13(and) polyisobutylene (and with) polysorbate-20,2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers, polyacrylamide/laureth-7/C13-14 isoparaffin, sodium polyacrylate (with) caprylic/capric triglyceride (with) Dormant oils (with) three (PPG-3 Semen Myristicae alcohol ether) citrate (with) the smooth laurate of Pyrusussuriensis (with) one or more in tridecyl alcohol polyethers-6.
6. a kind of novel skin antiallergic maintenance compositions according to claim 1, is characterized in that: described antiseptic is one or more in Methylisothiazolinone, DMDM Hydantoin, phenoxyethanol, BIT.
7. a kind of novel skin antiallergic maintenance compositions according to claim 1, is characterized in that: described skin-rehabilitating agent is the alcohol extract of Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis and the mixture of grape procyanidins.
8. a kind of novel skin antiallergic maintenance compositions according to claim 1, is characterized in that: described skin-rehabilitating agent is the grape procyanidins of Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis equal portions blend alcohol extract and equal portions.
9. a kind of novel skin antiallergic maintenance compositions according to claim 1, is characterized in that: main Effect raw material is Defensil and skin-rehabilitating agent combination.
10. a kind of novel skin antiallergic maintenance compositions according to claim 1, it is characterized in that: skin-rehabilitating agent preparation method is as follows: Herba Plantaginis, Herba Silybi mariani, Radix Sophorae Flavescentis raw material of Chinese medicine, clean, dry, get identical deal and pulverize after blend, with 1,50-70 ℃ of constant temperature of 3-butanediol stirs 2-4 hour, and standing 7-9 hour, gets supernatant liquid filtering, mix with the red wine polyphenols of equal portions, obtain skin-rehabilitating agent of the present invention.
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| FR3115989A1 (en) * | 2020-11-10 | 2022-05-13 | Naos Institute Of Life Science | COMPOSITION FOR THE TREATMENT OF ROSACEA AND/OR TELANGIECTASIA |
| US11813350B2 (en) | 2020-11-10 | 2023-11-14 | Jean-Noël Thorel | Composition for the treatment of rosacea and/or telangiectasia |
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