CN115607473A

CN115607473A - Anti-allergy soothing toner and preparation method thereof

Info

Publication number: CN115607473A
Application number: CN202211306046.7A
Authority: CN
Inventors: 周嘉奇
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-10-24
Filing date: 2022-10-24
Publication date: 2023-01-17

Abstract

The invention discloses anti-allergy soothing toner and a preparation method thereof. The anti-allergy soothing toner comprises the following components in percentage by weight: 1 to 4 percent of butanediol, 1 to 5 percent of dipropylene glycol, 1 to 5 percent of 1, 3-propylene glycol, 1 to 3 percent of sodium isosteviol, 1 to 3 percent of disodium succinyl glycyrrhetinate, 0.5 to 2 percent of sodium dianilin, 0.5 to 1.5 percent of octyl/decyl glucoside, 3 to 6 percent of humectant, 0 to 0.1 percent of preservative, 0.01 to 0.1 percent of metal chelating agent and the balance of deionized water. The anti-allergy soothing toner disclosed by the invention is stable and mild in raw material ratio, has obvious anti-allergy, anti-inflammatory, skin-calming and moisturizing effects, and can be used for a long time.

Description

Anti-allergy soothing toner and preparation method thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to anti-allergy soothing toner and a preparation method thereof.

Background

The toner is used as a product for secondary cleaning after face cleaning, and has the functions of secondary cleaning to recover the pH value of the surface of the skin, supplement and maintain the skin for a long time, condition the horny layer and prepare for using a maintenance product so that the skin can absorb better. At present, most of the skin lotions on the market have the effects of moisturizing and whitening, but most of the skin lotions contain ingredients of perfume, alcohol and heavy preservative, and easily cause burden on the skin with thin skin and the skin which is easily sensitive to external stimulation. Particularly alcohol, can cause redness of sensitive skin after application.

With the improvement of living standard of people, the pursuit of beauty is higher and higher, various adverse reactions are generated due to the use of a large amount of cosmetics, such as abnormal changes of skin physiological states of erythema, desquamation, pimple, stabbing pain, pruritus and the like, and the delicate skin of women needs to be cared in a great way, so that the development of the skin toner which is mild in nature, has a soothing and antiallergic effect, does not contain alcohol or spice and meets the market demand is needed.

Disclosure of Invention

The invention aims to provide an anti-allergy soothing toner and a preparation method thereof. The anti-allergy soothing toner is stable and mild in raw material ratio, has remarkable anti-allergy, anti-inflammatory, skin-calming and moisturizing effects, and can be used for a long time.

The invention is realized by the following technical scheme:

an anti-allergy soothing toner comprises the following components in percentage by weight: comprises the following components in percentage by weight: 1 to 4 percent of butanediol, 1 to 5 percent of dipropylene glycol, 1 to 5 percent of 1, 3-propylene glycol, 1 to 3 percent of sodium isosteviol, 1 to 3 percent of disodium succinyl glycyrrhetinate, 0.5 to 2 percent of sodium dianilin, 0.5 to 1.5 percent of octyl/decyl glucoside, 3 to 6 percent of humectant, 0 to 0.1 percent of preservative, 0.01 to 0.1 percent of metal chelating agent and the balance of deionized water.

Preferably, the anti-allergy soothing toner comprises the following components in percentage by weight: 2 to 4 percent of butanediol, 2 to 4 percent of dipropylene glycol, 3 to 5 percent of 1, 3-propylene glycol, 2 to 3 percent of sodium isosteviol, 2 to 3 percent of disodium succinyl glycyrrhetinate, 0.5 to 1.5 percent of sodium dianilin, 0.5 to 1 percent of octyl/decyl glucoside, 3 to 6 percent of humectant, 0 to 0.05 percent of preservative, 0.05 to 0.1 percent of metal chelating agent and the balance of deionized water.

Preferably, the anti-allergy soothing toner comprises the following components in percentage by weight: 3% of butanediol, 2% of dipropylene glycol, 5% of 1, 3-propylene glycol, 2.5% of sodium isosteviol, 2.5% of disodium succinyl glycyrrhetinate, 1% of sodium dianilin, 1% of octyl/decyl glucoside, 5% of humectant, 0.05% of preservative, 0.05% of metal chelating agent and the balance of deionized water.

Preferably, the humectant is at least one selected from glycerin, sodium hyaluronate, squalane, jojoba seed oil, beta-glucan, levan and tocopherol.

Preferably, the preservative is phenoxyethanol, ethylhexyl glycerol or a mixture of the phenoxyethanol and the ethylhexyl glycerol.

Preferably, the preservative is prepared by mixing phenoxyethanol and ethylhexyl glycerol according to a mass ratio of 9.

Preferably, the metal chelating agent is EDTA-2Na.

The invention also provides a method for preparing the anti-allergy soothing toner, which comprises the step of mixing the components of the anti-allergy soothing toner. Specifically, the preparation steps of the anti-allergy soothing toner are as follows:

mixing butanediol, dipropylene glycol, 1, 3-propanediol, octyl/decyl glucoside and deionized water according to the formula ratio, heating to 65-70 ℃, stirring to completely dissolve, cooling to 40-45 ℃, adding sodium isosteviol, disodium succinyl glycyrrhetinate, sodium dianthus chinensis, a humectant, a preservative and a metal chelating agent, uniformly mixing, and discharging to obtain the compound.

Isosteviol is a Bayesian diterpenoid compound derived from stevioside, and sodium isosteviol is its sodium salt, and has water solubility. The existing research shows that isosteviol has antioxidation, good inhibitory activity on tyrosinase, and whitening effect, and can inhibit the synthesis of melanin. The disodium succinyl glycyrrhetinate is a water-soluble derivative of glycyrrhetinic acid, has good effects of resisting inflammation, preventing allergy and removing toxic substances, and has certain irritation to skin and eyes. The caryophyllin sodium is water soluble sodium salt of oleanolic acid, has excellent antiinflammatory, antibacterial and antioxidant effects, and has certain irritation to skin and eyes. The inventor researches and discovers that when sodium isosteviol, disodium succinyl glycyrrhetinate and sodium caryophyllin are compounded for use, synergistic antiallergic, anti-inflammatory and sedative effects can be achieved, irritation to skin and eyes is greatly reduced, and unexpected technical effects are achieved. The sodium isosteviol, the disodium succinyl glycyrrhetinate and the dianthus caryophyllus sodium can be used as effective components for preparing the anti-allergy soothing toner, and have the advantages of low irritation, high safety and long-term use.

In addition, as the dianthus chinensis sodium has certain antibacterial activity, the toner can maintain the stability of a system without adding any preservative or only adding a small amount of preservative, and achieves the effect of long-term use. And the reduction of the dosage of the preservative is beneficial to reducing the irritation of the toner.

The invention has the following beneficial effects:

the sodium isosteviol, the disodium succinyl glycyrrhetinate and the dianthus chinensis sodium in the formula of the anti-allergy and soothing toner provided by the invention exert synergistic anti-allergy, anti-inflammatory and skin calming effects, and greatly reduce irritation to skin and eyes. The anti-allergy soothing toner is mild and non-irritant, has a stable system, and can be used for a long time.

Detailed Description

The following examples are further illustrative of the present invention and are not intended to be limiting thereof. The components of the formulations in the following examples are, unless otherwise specified, conventional commercial products. Wherein the sodium isosteviol is obtained from Dongguan Kai method biological medicine Co.

Example 1

An anti-allergy soothing toner comprises the following components in percentage by weight: 3% of butanediol, 2% of dipropylene glycol, 5% of 1, 3-propylene glycol, 2.5% of sodium isosteviol, 2.5% of disodium succinyl glycyrrhetinate, 1% of sodium dianilin, 1% of octyl/decyl glucoside, 3% of glycerol, 2% of jojoba seed oil, 0.045% of phenoxyethanol, 0.005% of ethylhexyl glycerol, 0.05% of EDTA-2Na and the balance of deionized water.

The preparation steps are as follows: mixing butanediol, dipropylene glycol, 1, 3-propylene glycol, octyl/decyl glucoside and deionized water according to the formula amount, heating to 70 ℃, stirring to completely dissolve, cooling to 40 ℃, adding sodium isosteviol, disodium succinyl glycyrrhetinate, sodium dianthus chinensis, glycerol, jojoba seed oil, phenoxyethanol, ethylhexyl glycerol and EDTA-2Na, uniformly mixing, and discharging to obtain the product.

Example 2

An anti-allergy soothing toner comprises the following components in percentage by weight: 2% of butanediol, 4% of dipropylene glycol, 3% of 1, 3-propylene glycol, 3% of sodium isosteviol, 2% of disodium succinyl glycyrrhetinate, 1.5% of sodium dianiline, 0.5% of octyl/decyl glucoside, 2% of glycerol, 4% of sodium hyaluronate, 0.045% of phenoxyethanol, 0.005% of ethylhexyl glycerol, 0.1% of EDTA-2Na and the balance of deionized water.

The preparation procedure is as in example 1.

Example 3

An anti-allergy soothing toner comprises the following components in percentage by weight: 4% of butanediol, 5% of dipropylene glycol, 1, 3-propylene glycol, 1% of sodium isosteviol, 1% of disodium succinyl glycyrrhetinate, 2% of sodium dianiline, 1% of octyl/decyl glucoside, 2% of jojoba seed oil, 1% of tocopherol, 0.05% of EDTA-2Na and the balance of deionized water.

Preparation procedure reference example 1 was made.

Example 4

An anti-allergy soothing toner comprises the following components in percentage by weight: 1% of butanediol, 5% of dipropylene glycol, 4% of 1, 3-propylene glycol, 3% of sodium isosteviol, 3% of disodium succinyl glycyrrhetinate, 1% of dianilin sodium, 1.5% of octyl/decyl glucoside, 3% of glycerol, 1% of squalane, 0.045% of phenoxyethanol, 0.005% of ethylhexyl glycerol, 0.01% of EDTA-2Na and the balance of deionized water.

Preparation procedure reference example 1 was made.

Example 5

An anti-allergy soothing toner comprises the following components in percentage by weight: 3% of butanediol, 1% of dipropylene glycol, 4% of 1, 3-propylene glycol, 1% of sodium isosteviol, 2.5% of disodium succinyl glycyrrhetinate, 0.5% of sodium dianilin, 0.5% of octyl/decyl glucoside, 2% of glycerol, 2% of sodium hyaluronate, 1% of fructan, 0.09% of phenoxyethanol, 0.01% of ethylhexyl glycerol, 0.01% of EDTA-2Na0.01% and the balance of deionized water.

The preparation procedure is as in example 1.

Comparative example 1

The anti-allergy soothing toner of comparative example 1 is different from that of example 1 in that the formulation does not contain sodium isosteviol and the amounts of disodium succinylglycyrrhetinate and sodium dianiline are increased accordingly, the amount of disodium succinylglycyrrhetinate is 3% and the amount of sodium dianiline is 3%.

The preparation procedure is as in example 1.

Comparative example 2

Compared with the anti-allergy soothing toner in the example 1, the anti-allergy soothing toner in the comparative example 2 is different in that the formula does not contain succinyl glycyrrhetinic acid disodium, and the dosage of sodium isosteviol and the dosage of sodium dianthus chinensis are correspondingly increased, wherein the dosage of sodium isosteviol is 3%, and the dosage of sodium dianthus chinensis is 3%.

The preparation procedure is as in example 1.

Comparative example 3

The anti-allergy soothing toner of comparative example 3 is different from that of example 1 in that the formula does not contain the dianilin sodium, and the dosage of the sodium isosteviol and the dosage of the disodium succinyl glycyrrhetinate are correspondingly increased, wherein the dosage of the sodium isosteviol is 3 percent, and the dosage of the disodium succinyl glycyrrhetinate is 3 percent.

Preparation procedure reference example 1 was made.

Comparative example 4

The anti-allergy soothing toner of comparative example 4 is different from that of example 1 in that the formula does not contain sodium isosteviol and disodium succinyl glycyrrhetinate, and the amount of the dianilin sodium is increased correspondingly, wherein the amount of the dianilin sodium is 6%.

Preparation procedure reference example 1 was made.

Comparative example 5

The anti-allergy soothing toner of comparative example 5 is compared with that of example 1, except that the formulation does not contain sodium isosteviol and sodium dianiline, and the amount of disodium succinyl glycyrrhetinate is increased correspondingly, and the amount of disodium succinyl glycyrrhetinate is 6%.

Preparation procedure reference example 1 was made.

Comparative example 6

The anti-allergy soothing toner of comparative example 6 is different from that of example 1 in that disodium succinylglycyrrhetinate and sodium dianiline are not contained in the formulation, and the amount of sodium isosteviol is increased accordingly, and the amount of sodium isosteviol is 6%.

The preparation procedure is as in example 1.

Test example one, skin and eye irritation test

The anti-allergy soothing toner prepared in examples 1-5 and comparative examples 1-6 were subjected to an acute skin irritation test and an acute eye irritation test, and the specific experimental methods, scoring standards and irritation response grading are all referred to in the 2007 edition of "cosmetic hygiene code", and the results are shown in table 1.

TABLE 1

As can be seen from the above table 1, the anti-allergy soothing toner prepared in the embodiments 1-5 of the invention has no irritation in the acute skin irritation test and the acute eye irritation test, which shows that the anti-allergy soothing toner has mild formulation property and is safe to use. The toner of comparative examples 1, 4, and 5, which contained no sodium isosteviol, but either disodium succinyl glycyrrhetinate, sodium dianthus, or a mixture of both, exhibited mild irritation to both the skin and eyes. The results show that the addition of the two components of the disodium succinylglycyrrhetinate and the sodium dianiline can generate certain irritation to skin and eyes, and the addition of the sodium isosteviol can greatly reduce the irritation of the two components.

Test example two, patch test on human skin

The anti-allergy soothing toner prepared in the embodiments 1-5 of the invention is tested by referring to related requirements and determination methods of a human skin patch test in 2015 edition of cosmetic hygiene Specification published by the Ministry of health, skin reactions are observed at 0h, 6h, 12h, 24h and 48h respectively, the experimental results of all volunteers are negative results, and no adverse skin reactions occur. The anti-allergy soothing toner provided by the invention is free from anaphylactic reaction, free from irritation and high in safety.

Test example three, evaluation of Using Properties

66 volunteer healthy female subjects aged 18-55 years were selected and divided into 1-11 groups of 6 persons, and no drugs such as anti-inflammatory drugs and antihistamines were taken before the experiment, and no cosmetic allergy history existed. The anti-allergy soothing toner prepared in examples 1-5 was used in groups 1-5, respectively, and the anti-allergy soothing toner prepared in comparative examples 1-6 was used in groups 6-11, respectively.

First, 6cm was selected from the medial side of the right arm of the volunteer ² The size of skin was used as an experimental area, and the skin erythema index EI value of the experimental area was measured using a skin melanin and heme tester (mexameter MX 18, courage + Kahazaka, germany), and the skin sensitivity value of the experimental area was measured using a skin sensitivity tester (TiVi, wheels bridge, germany) as data (baseline value) before the experiment. Then, the skin barrier of the subject was destroyed by tape-sticking, and the skin erythema index EI value and skin sensitivity value after skin irritation were measured by using 1mL of histamine which was 1.5mg/mL for stimulation modeling. Then, the experimental groups are respectively smeared with corresponding anti-allergy soothing toner with the dosage of 1mL, and after the application for 30 minutes, the skin erythema index EI value and the skin sensitivity value of the experimental area are measured again. The results are shown in Table 2.

The same volunteer subjects used anti-allergy soothing toner for each test group after cleansing facial skin in the morning and evening every day, other anti-allergy soothing products could not be used during the test period, and water loss of facial skin was measured by a water loss test probe Tewameter TM300 (Courage + Kahazaka, germany) before, 14 days and 28 days after, respectively, and the results are shown in Table 3.

TABLE 2

TABLE 3

As can be seen from the above tables 2 to 3, the anti-sensitivity soothing toners prepared in examples 1 to 5 of the present invention were used to lower the EI value, skin sensitivity value and the TEWL value of the skin water loss, and the effects were superior to those of the toners prepared in comparative examples 1 to 6. The anti-allergy soothing toner prepared in the embodiments 1-5 of the invention has the effects of relieving skin erythema reaction, soothing skin sensitivity state and repairing skin barrier, and has obvious anti-allergy, anti-inflammatory, skin-calming and moisturizing effects.

The above are only preferred embodiments of the present invention, and it should be noted that the above preferred embodiments should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and should be considered to be within the scope of the invention.

Claims

1. The anti-allergy soothing toner is characterized by comprising the following components in percentage by weight: 1 to 4 percent of butanediol, 1 to 5 percent of dipropylene glycol, 1 to 5 percent of 1, 3-propylene glycol, 1 to 3 percent of sodium isosteviolate, 1 to 3 percent of disodium succinyl glycyrrhetinate, 0.5 to 2 percent of sodium caryophyllotoxin, 0.5 to 1.5 percent of octyl/decyl glucoside, 3 to 6 percent of humectant, 0 to 0.1 percent of preservative, 0.01 to 0.1 percent of metal chelating agent and the balance of deionized water.

2. The anti-allergy soothing toner according to claim 1, which comprises the following components in percentage by weight: 2 to 4 percent of butanediol, 2 to 4 percent of dipropylene glycol, 3 to 5 percent of 1, 3-propylene glycol, 2 to 3 percent of sodium isosteviolate, 2 to 3 percent of disodium succinyl glycyrrhetinate, 0.5 to 1.5 percent of sodium caryophyllotoxin, 0.5 to 1 percent of octyl/decyl glucoside, 3 to 6 percent of humectant, 0 to 0.05 percent of preservative, 0.05 to 0.1 percent of metal chelating agent and the balance of deionized water.

3. The anti-allergy soothing toner according to claim 2, which comprises the following components in percentage by weight: 3% of butanediol, 2% of dipropylene glycol, 5% of 1, 3-propylene glycol, 2.5% of sodium isosteviol, 2.5% of disodium succinyl glycyrrhetinate, 1% of sodium dianilin, 1% of octyl/decyl glucoside, 5% of humectant, 0.05% of preservative, 0.05% of metal chelating agent and the balance of deionized water.

4. The anti-sensitivity soothing toner according to any one of claims 1 to 3, wherein the moisturizer is at least one selected from the group consisting of glycerin, sodium hyaluronate, squalane, jojoba oil, beta-glucan, levan, and tocopherol.

5. The anti-allergy soothing toner according to any one of claims 1 to 3, wherein the preservative is phenoxyethanol, ethylhexyl glycerin or a mixture of the two.

6. The anti-allergy soothing toner according to claim 5, wherein the preservative is composed of phenoxyethanol and ethylhexyl glycerin in a mass ratio of 9.

7. The anti-sensitivity soothing toner according to any one of claims 1 to 3, wherein the metal chelating agent is EDTA-2Na.

8. A process for preparing the anti-sensitivity soothing toner of any one of claims 1-7 comprising the step of mixing the components of the anti-sensitivity soothing toner.

9. The method of claim 8, comprising the steps of: