CN104146925A - Facial mask with functions of improving skin barrier and delaying senescence and preparation method thereof - Google Patents
Facial mask with functions of improving skin barrier and delaying senescence and preparation method thereof Download PDFInfo
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- CN104146925A CN104146925A CN201410436054.2A CN201410436054A CN104146925A CN 104146925 A CN104146925 A CN 104146925A CN 201410436054 A CN201410436054 A CN 201410436054A CN 104146925 A CN104146925 A CN 104146925A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 230000006870 function Effects 0.000 title abstract description 10
- 230000009758 senescence Effects 0.000 title abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 55
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- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of daily care products and discloses a facial mask with the functions of improving skin barrier and delaying senescence and a preparation method thereof. The facial mask comprises the following components in percentage by weight: 0.05-4 percent of macromolecule hyaluronic acid, 0.1-3 percent of middle molecule hyaluronic acid, 0.1-5 percent of micromolecule hyaluronic acid, 0.05-3 percent of oligomeric hyaluronic acid, 0.5-6 percent of grape seed extract, 0.5-6 percent of purslane extract, 2-12 percent of hydroxyethyl urea, 1-6 percent of sodium pyrrolidonecarboxylate, 0.1-1 percent of allantoin, 2-12 percent of butanediol, 0.05-0.3 percent of thickening agent and the balance of deionized water. According to the facial mask disclosed by the invention, by reasonably combining natural compounds with plant extracts, the synergistic effect is realized, and the functions of better improving the skin barrier and delaying the senescence are achieved.
Description
Technical field
The invention belongs to daily nursing product technical field, be specifically related to a kind of facial film of improving skin barrier function and function of delaying senility and preparation method thereof that has.
Background technology
Along with the development of modern society, rhythm of life is also in continuous quickening, and the thing that people face processing also becomes increasingly complex, more and more diversified.Allegro life style allow most of modern experiencing pressure, stay up late, do not have enough sleep, live irregular etc.
Allegro life style, causes body in sub-health state.Year in and year out, it is fragile that self barrier ability of skin becomes thereupon, and skin is accelerated ageing also.It characterizes as pigmented spots, wrinkle etc. just slowly display.The barrier function of skin is the skin surface natural defence line of first of environment to external world, and it can prevent the intrusion of extraneous chemistry, physics, machinery, biological factors, can prevent that again moisture, nutrient substance from losing through epidermis.If it is fragile that skin barrier function becomes, can make moisture of skin lose, cause various skin problem, as in the time that skin barrier is impaired, skin is more easily irritated, and inflammation is rubescent, and oil yield increases, and storage capacity reduces, cutin is undesired to come off, decortication, and acne increases etc.
If skin is in exsiccosis for a long time, skin can be more easily old and feeble, and adding barrier ability is affected and cause fragility by various extraneous undesirable element, more easily doubles the aging of skin.
It is a complicated diversification process that formation skin accelerates old and feeble reason, and slow down aging does not refer to and allows people's natural aging of slowing down, but antagonism human body because with extraneous continuous contact, comprise that the reason such as outside contamination, radiation exposure constantly produces the factor of the acceleration skin aging that free radical causes in body.
So want to reach effect of water profit skin care slow down aging, first first problem is exactly the ability that will improve or strengthen the extraneous undesirable element of skin natural cover, is ensuing cosmetology create environment.
In prior art, moisture-keeping functions basic ingredient is generally by adding propylene glycol and glycerol to provide moisturizing basic effect, but these wetting agents have certain zest to skin, and more oily sticky, uses perceptual difference; Be exactly the object that reaches skin anti-aging by adding plant extract in addition, but the interpolation of plant extract generally to consider with formula in compatibility and the synergism of other component, inappropriate formula often cannot be given full play to effect or the action effect of plant extract can not be lasting.
Summary of the invention
In order to solve the shortcoming and defect part of prior art, primary and foremost purpose of the present invention is to provide a kind of facial film that improves skin barrier function and function of delaying senility that has.
Another object of the present invention is to provide the above-mentioned preparation method with barrier function and function of delaying senility facial film.
The object of the invention is achieved through the following technical solutions:
There is a facial film that improves skin barrier function and function of delaying senility, the component that comprises following quality percentage composition:
The quality percentage composition of above-mentioned facial film component is preferably:
The hyaluronic acid that the preferred mean molecule quantity of described sub-Q is 1,800,000; The hyaluronic acid that the preferred mean molecule quantity of middle molecule hyaluronic acid is 1,000,000; The hyaluronic acid that the preferred mean molecule quantity of micromolecule hyaluronic acid is 200,000; The preferred mean molecule quantity of oligomerization hyaluronic acid is the hyaluronic acid below 10,000.
The preferred hydroxyethyl-cellulose of described thickening agent.
Above-mentioned have a facial film that improves skin barrier function and function of delaying senility, also comprises the component of following quality percentage composition:
Above-mentioned have a preparation method of improving skin barrier function and function of delaying senility facial film, comprises following operating procedure:
(1) vitamin E, allantoin are joined and in butanediol, carry out moltenly in advance, be heated to 50 DEG C of dissolvings, form mixed liquor;
(2) deionized water is added to emulsifying pot, thickening agent, sub-Q, middle molecule hyaluronic acid, micromolecule hyaluronic acid, oligomerization hyaluronic acid are scattered in deionized water, be stirred to completely and dissolve, form principal phase;
(3), by hydroxyethyl urea, pyrrolidone sodium carboxylate, joins in principal phase and is heated to 75 DEG C until dissolve completely;
(4) material that step (3) obtains is cooled to 45 DEG C, add the mixed liquor of step (1), then add successively Semen Vitis viniferae plant extract, Herba portulacae extract, Folium Bambosae extract, Sargassum extract, chamomile extract to be fully uniformly mixed, obtain having the facial film that improves skin barrier function and function of delaying senility.
The action principle of recipe ingredient of the present invention is:
Pyrrolidone sodium carboxylate: be a kind of natural moisture preserving agent with good moisture pick-up properties, long-acting moisture retention is strong.As the important composition of natural Moisture factor, be present in a large number in keratodermatitis.And nontoxic, non-stimulated, good stability, if the pyrrolidone sodium carboxylate content in keratodermatitis reduces, it is dry and coarse that skin can become.This composition can increase the water content of keratodermatitis, maintains the tender and elasticity of skin, makes skin be rich in gloss.Make skin barrier function keep normalization, must cuticular water content abundance.
Semen Vitis viniferae extract: Semen Vitis viniferae extract is one of high-efficiency antioxidant agent of the plant origin found so far, in body and in vitro tests shows that the antioxidant effect of Semen Vitis viniferae extract " procyanidin OPC " is ascorbic 20 times and vitamin E 50 times.Superpower antioxidation efficiency has the effect of removing free radical, slow down aging, and procyanidin can be repaired injured collagen protein and elastic fiber, has astriction, tightens up skin, prevents that wrinkle of skin from occurring ahead of time, slow down aging.Procyanidin is natural sunlight overcover, and the effectively infringement of shielding of ultraviolet to skin avoids barrier function to become fragile.Procyanidin can activating cell, assists to strengthen the moisture preserving time of other moisturizing compositions, pins moisture, reaches the effect of long-acting moisturizing.
Herba portulacae extract: main effect is the various stimulations of antiallergic, antiinflammatory antiinflammatory and the outer bound pair skin of opposing, also has acne-removal function.The skin allergy especially life-time service hormones cosmetics being produced has obvious anti-allergic effects; Nowadays very many of the example that cosmetics inferior cause skin allergy, by adding Herba portulacae extract, can improve the discomfort that extraneous factor causes the stimulation of skin, as irritated, inflammation is rubescent etc., auxiliaryly improves the impaired state that skin barrier function causes because of extraneous factor.
Hyaluronic acid: be one of composition of human body dermal tissue.Hyaluronic acid can disappear with age, makes skin lose the ability of water storage, becomes gradually coarse, obscure, aging, and forms tiny wrinkle.
Sub-Q can form the water conservation thin film that one deck is ventilative at skin surface, and catches airborne hydrone.Make skin smooth moistening, strengthen skin vigor, can effectively smooth microgroove, make the tender gloss of skin, high resilience, skin water oil balance simultaneously.And can assist skin barrier function to alien bacteria, dust, ultraviolet intrusion, protection skin is avoided infringement.
The middle molecule hyaluronic acid skin that can compact, pins skin moisture, strengthens skin moisturizing ability.Can enter keratodermatitis, aquation skin keratin cell, prevents horn cell decline ahead of time, delays the vitality of cell, and fills the moisture of epidermal keratinocyte interlayer, allows old useless cell naturally come off.
Micromolecule hyaluronic acid can infiltrate dermal layer of the skin fast, participates in the generation of collagen protein, and supplementary intercellular substance.Increase blood circulation, improve intermediate supersession, promote skin to the faster Absorption of nutrition.Can increase skin elasticity, delay skin aging.To the replenishing water and preserving moisture effect of skin by corium to epidermis, comprehensive deep layer nourishing effect of real meaning.
Oligomerization hyaluronic acid is a kind of than the more micro-micromolecular a kind of hyaluronic acid of micromolecule, to pass through technological means by conventional hyaluronic acid, sub-Q is given to a kind of nanoscale hyaluronic acid that cuts into extra small molecular weight, directly Transdermal absorption participate in the various activities of Skin Cell, provide adequate water to regenerative cell, and repair fast damaged cell, there is powerful reparation power to shining rear skin, it even can distributed by capillarity, improve blood vessel elasticity, help improve red blood streak situation, sensitive skin is had to long-term opsonic action.
Hydroxyethyl urea: hydroxyethyl urea is splendid wetting agent, can provide efficient moisture-retention effect simultaneously again without sticky feel to skin, and hydroxyethyl urea can penetrate in keratodermatitis, increases moisture content of skin, alleviates and is dried, and fills up microgroove, increases skin elasticity.One of vital point that maintains skin barrier function normalization is exactly the water content that keeps skin.
Butanediol: be the fabulous wetting agent of moisturizing safety, non-stimulated, quality is clearly not sticky.Skin care, increases skin glossiness.
Allantoin: allantoin can make skin keep moisture content, moistens and soft, have protection skin histology, hydrophilic, absorb water and the effect such as prevent that moisture from distributing;
Vitamin E: there is antioxidation; Skin is had to moist effect, can firmly pin moisture.
Sargassum extract: be a kind of good emollient, can, by forming hydration with other moisturizing compositions, form protecting film at skin surface, prevent moisture evaporation.Sargassum extract contains " superoxide dismutase ", there is the effect of removing free radical.
Folium Bambosae extract: there is skin care, eliminate free radical, improve effect of xerosis cutis state.
Chamomile extract: the excellent skin effect of releiving, sunburn is repaired and improved responsive skin there is good assosting effect, pacify skin, reduce irritated probability.
Product of the present invention and preparation method tool have the following advantages and beneficial effect:
(1) what first face pack prescription of the present invention was emphasized is the barrier function that improves skin, by thering is the reasonable combination of the compound and the plant extract that improve skin barrier function, can be skin long-acting guard mode is provided, stop skin water loss and assist the damage of the extraneous poor environment of opposing to skin;
(2) face pack prescription of the present invention, having under the prerequisite of improving barrier function, has the plant extract of function of delaying senility by interpolation, can, by the good effectively absorption of skin, give full play to the function of delaying senility of plant extract;
(3) face pack prescription of the present invention is by adding oligomerization hyaluronic acid and Semen Vitis viniferae extract, can form inside and outside antidotal synergism to skin, hyaluronic acid itself is just present in human body skin, and oligomerization hyaluronic acid is a kind of nano level hyaluronic acid, molecular weight is ultralow, so can repair from skin internal layer, improves aging phenomenon, Semen Vitis viniferae extract can be eliminated the aging phenomenon causing because of extraneous factor, reaches good defying age effect by the combination of inner and outside;
(4) by adding the hyaluronic acid of large, medium and small different molecular weight, can strengthen lock water function and the deep layer nourishing effect of the present invention's formula, in addition by adding micromolecule hyaluronic acid, also can promote the absorption of skin to other nutritional labelings in formula;
(5) can significantly reduce zest that formula components of the present invention may cause or the probability of other untoward reaction by adding Herba portulacae extract;
(6) there is moisturizing lock water and the pyrrolidone sodium carboxylate that improves skin barrier function by interpolation, for good condition has been created in the performance of the Semen Vitis viniferae extract function of delaying senility in the present invention's formula;
(7) by adding Sargassum extract, there is hydration with other moisturizing compositions in the present invention's formula, form surface protection film, prevent water loss;
(8) formula of the present invention, by having the good combination of improving between the component of skin barrier function and the component of delay skin aging effect, makes effect of slow down aging in formula obtain effective and lasting performance;
(9) in the present invention formula, do not add this class such as propylene glycol and glycerol to skin irritation large and greasy foul moisturizing composition, use sense is better, product milder is safe.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1
The present embodiment a kind of has the facial film that improves skin barrier function and function of delaying senility, is made up of the component of following quality percentage composition:
The above-mentioned preparation method with barrier function and senile-resistant efficacy facial film, concrete operation step is as follows:
(1) allantoin is joined and in butanediol, carry out moltenly in advance, be heated to 50 DEG C of dissolvings, form mixed liquor;
(2) deionized water is added to emulsifying pot, thickening agent hydroxyethyl-cellulose, sub-Q, middle molecule hyaluronic acid, micromolecule hyaluronic acid, oligomerization hyaluronic acid are scattered in deionized water, be stirred to completely and dissolve, form principal phase;
(3), by hydroxyethyl urea, pyrrolidone sodium carboxylate, joins in principal phase and is heated to 75 DEG C until dissolve completely;
(4) material that step (3) obtains is cooled to 45 DEG C, add the mixed liquor of step (1), then add successively Semen Vitis viniferae plant extract, Herba portulacae extract to be fully uniformly mixed, obtain having the facial film that improves skin barrier function and function of delaying senility.
Embodiment 2
The present embodiment a kind of has the facial film that improves skin barrier function and function of delaying senility, is made up of the component of following quality percentage composition:
The above-mentioned preparation method with barrier function and senile-resistant efficacy facial film, concrete operation step is as follows:
(1) allantoin is joined and in butanediol, carry out moltenly in advance, be heated to 50 DEG C of dissolvings, form mixed liquor;
(2) deionized water is added to emulsifying pot, thickening agent hydroxyethyl-cellulose, sub-Q, middle molecule hyaluronic acid, micromolecule hyaluronic acid, oligomerization hyaluronic acid are scattered in deionized water, be stirred to completely and dissolve, form principal phase;
(3), by hydroxyethyl urea, pyrrolidone sodium carboxylate, joins in principal phase and is heated to 75 DEG C until dissolve completely;
(4) material that step (3) obtains is cooled to 45 DEG C, add the mixed liquor of step (1), then add successively Semen Vitis viniferae plant extract, Herba portulacae extract to be fully uniformly mixed, obtain having the facial film that improves skin barrier function and function of delaying senility.
Embodiment 3
The present embodiment a kind of has the facial film that improves skin barrier function and function of delaying senility, is made up of the component of following quality percentage composition:
The above-mentioned preparation method with barrier function and senile-resistant efficacy facial film, concrete operation step is as follows:
(1) allantoin is joined and in butanediol, carry out moltenly in advance, be heated to 50 DEG C of dissolvings, form mixed liquor;
(2) deionized water is added to emulsifying pot, thickening agent hydroxyethyl-cellulose, sub-Q, middle molecule hyaluronic acid, micromolecule hyaluronic acid, oligomerization hyaluronic acid are scattered in deionized water, be stirred to completely and dissolve, form principal phase;
(3), by hydroxyethyl urea, pyrrolidone sodium carboxylate, joins in principal phase and is heated to 75 DEG C until dissolve completely;
(4) material that step (3) obtains is cooled to 45 DEG C, add the mixed liquor of step (1), then add successively Semen Vitis viniferae plant extract, Herba portulacae extract to be fully uniformly mixed, obtain having the facial film that improves skin barrier function and function of delaying senility.
Embodiment 4
The present embodiment a kind of has the facial film that improves skin barrier function and function of delaying senility, is made up of the component of following quality percentage composition:
The above-mentioned preparation method with barrier function and senile-resistant efficacy facial film, concrete operation step is as follows:
(1) vitamin E, allantoin are joined and in butanediol, carry out moltenly in advance, be heated to 50 DEG C of dissolvings, form mixed liquor;
(2) deionized water is added to emulsifying pot, thickening agent hydroxyethyl-cellulose, sub-Q, middle molecule hyaluronic acid, micromolecule hyaluronic acid, oligomerization hyaluronic acid are scattered in deionized water, be stirred to completely and dissolve, form principal phase;
(3), by hydroxyethyl urea, pyrrolidone sodium carboxylate, joins in principal phase and is heated to 75 DEG C until dissolve completely;
(4) material that step (3) obtains is cooled to 45 DEG C, add the mixed liquor of step (1), then add successively Semen Vitis viniferae plant extract, Herba portulacae extract, Folium Bambosae extract, Sargassum extract and chamomile extract to be fully uniformly mixed, obtain having the facial film that improves skin barrier function and function of delaying senility.
Comparative example 1
A kind of facial film of this comparative example does not add hydroxyethyl urea and pyrrolidone sodium carboxylate compared with embodiment 1, and all the other components and preparation method are identical.
Comparative example 2
A kind of facial film of this comparative example does not add sub-Q, middle molecule hyaluronic acid, micromolecule hyaluronic acid and oligomerization hyaluronic acid compared with embodiment 1, and all the other components and preparation method are identical.
Product effect assessment
The evaluation of delay skin aging effect: not using before product, measure facial skin elasticity by " MPA580 elasticity tester "; Measure wrinkle and the pore data in facial skin by " VISIA skin detection instrument ", then test by human face practical application product, with use in every two days once, apply face at night and use, each 15 minutes.After the use of eight time-of-weeks, reuse " MPA580 elasticity tester " and " VISIA skin detection instrument " carries out the test of facial skin, contrast with the data of implementing before test, and uses the difference of product front and back by perusal.Front and back difference is greater than 10% and shows that effect is remarkable, and difference is to indicate certain effect between 5%～10%, and difference is less than 5% expression and is not improved.
The evaluation of moistening effect: test by " skin moisture content tester corneometer ", this instrument can detect low-down electric current, and the effect that moistening skin transmits faint electric current is better than dry skin.The method adopts the cuticular moisture of capacitance measurement human body skin, its principle is that the difference in dielectric constant based on water and other materials is remarkable, according to the difference of moisture content of skin, the capacitance difference of the skin recording, observes its parameter can represent skin moisture value.Concrete moistening effect testing procedure: the moistening effect test of this product is by implementing test in human arm inner side.Before test, need to survey in cleaner arm, by dry medicated napkin wiped clean.In experiment, left and right arm inside buoy note 4cm × 4cm pilot region, same arm can be with the multiple regions of tense marker, interregional every 1cm.Embodiment product and comparative example product are all randomly dispersed on the arm of left and right.Use test instrument is measured test zone, and each region is according to parallel assay 5 times.First measure the blank value of each test zone, then use latex finger cot that test products is evenly coated in pilot region.After smearing, while measuring respectively 1h, 2h and 4h, the moisture content of skin of test zone.
Improve the evaluation of skin barrier function:, before use test product, by " moisture of skin loss tester (TEWL) ", experimenter's skin is not implemented to the test that moisture content runs off, and record data.The measuring principle of this test instrunment derives from Fick's law of diffusion.Measure nearly epidermis (in about 1cm) by 2 groups of temperature-humidity sensors, in different 2 steam barometric gradients that form, directly measure the water quantities of distributing through epidermis by horny layer moisture loss.TEWL value is an important symbol of skin barrier quality, and the numerical value that use test instrument is measured is lower, illustrates that the barrier function of skin is just better, otherwise, poorer.Protective layer of skin is more intact, and the content of moisture content will be higher, and the numerical value of skin moisture loss TEWL is just lower, and (unit of TEWL is: g/hm
2).Then test by human face practical application product, with use in every two days once, apply face at night and use, each 15 minutes.After the use of eight time-of-weeks, reuse TEWL facial skin is detected, the difference before and after relatively using.Front and back difference is greater than 10% and shows that effect is remarkable, and difference is to indicate certain effect between 5%～10%, and difference is less than 5% expression and is not improved.
The evaluation of zest and untoward reaction: first soak a piece of cloth with distilled water or normal saline, be screwed onto one half-dried, and be folded into 4 layers of approximately 1 centimeter square size, the facial mask liquid of this product is coated in to the one side of cloth, then apply on human body hands forearm inner side or back normal skin, cover again air-locked cellophane or plastic sheeting, with immobilization with adhesive tape.Through the observation of 24～48 hours, test position was without any abnormal, do not occur that play is itched or the symptom such as causalgia, showed that this product is to skin nonirritant.Then test by human face practical application product, with use in every two days once, apply face use at night, each 15 minutes, the service condition that continues to observe eight time-of-weeks, as without any untoward reaction, showed that this product is safer to skin.
Above embodiment and comparative example product effect assessment result are as shown in table 1:
Table 1 product effect assessment result
Can be found out by upper table result, lacking after hydroxyethyl urea and pyrrolidone sodium carboxylate, product improves skin barrier function and significantly reduces, and owing to improving the reduction of skin barrier function, effect of product delay skin aging is also subject to certain impact, this is because do not improving under the condition of skin barrier function, and the composition with delay skin aging effect can not effectively lasting playing a role; In addition in the case of not adding the hyaluronic acid of four kinds of different molecular weights, the effect with the plant extract of senile-resistant efficacy can not get effective performance, this is likely that plant extract can not effectively be absorbed by skin, and added after the hyaluronic acid of four kinds of different molecular weights, can promote the effective absorption of skin to plant extract, and then play a role.
Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and principle, substitutes, combination, simplify; all should be equivalent substitute mode, within being included in protection scope of the present invention.
Claims (6)
1. there is a facial film that improves skin barrier function and function of delaying senility, it is characterized in that: the component that described facial film comprises following quality percentage composition:
2. a kind of facial film that improves skin barrier function and function of delaying senility that has according to claim 1, is characterized in that: the component that described facial film comprises following quality percentage composition:
3. a kind of facial film that improves skin barrier function and function of delaying senility that has according to claim 1 and 2, is characterized in that: described sub-Q is that mean molecule quantity is 1,800,000 hyaluronic acid; Middle molecule hyaluronic acid is that mean molecule quantity is 1,000,000 hyaluronic acid; Micromolecule hyaluronic acid is that mean molecule quantity is 200,000 hyaluronic acid; Oligomerization hyaluronic acid is the hyaluronic acid that mean molecule quantity is less than 10,000.
4. a kind of facial film that improves skin barrier function and function of delaying senility that has according to claim 1 and 2, is characterized in that: described thickening agent is hydroxyethyl-cellulose.
5. a kind of facial film that improves skin barrier function and function of delaying senility that has according to claim 1 and 2, is characterized in that: described facial film also comprises the component of following quality percentage composition:
6. a kind of preparation method with the facial film that improves skin barrier function and function of delaying senility claimed in claim 5, is characterized in that comprising following operating procedure:
(1) vitamin E, allantoin are joined and in butanediol, carry out moltenly in advance, be heated to 50 DEG C of dissolvings, form mixed liquor;
(2) deionized water is added to emulsifying pot, thickening agent, sub-Q, middle molecule hyaluronic acid, micromolecule hyaluronic acid, oligomerization hyaluronic acid are scattered in deionized water, be stirred to completely and dissolve, form principal phase;
(3), by hydroxyethyl urea, pyrrolidone sodium carboxylate, joins in principal phase and is heated to 75 DEG C until dissolve completely;
(4) material that step (3) obtains is cooled to 45 DEG C, add the mixed liquor of step (1), then add successively Semen Vitis viniferae plant extract, Herba portulacae extract, Folium Bambosae extract, Sargassum extract, chamomile extract to be fully uniformly mixed, obtain having the facial film that improves skin barrier function and function of delaying senility.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012101638A2 (en) * | 2011-01-24 | 2012-08-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Nanoparticles for cosmetic applications |
| CN103536476A (en) * | 2013-10-17 | 2014-01-29 | 苏州威尔德工贸有限公司 | Grape seed oil skin protection cream and preparation method thereof |
| CN103622864A (en) * | 2013-01-30 | 2014-03-12 | 广东雅丽洁精细化工有限公司 | Multifunctional aloe gel and preparation method thereof |
| CN104000757A (en) * | 2014-05-26 | 2014-08-27 | 乌鲁木齐阿芙罗商贸有限公司 | External preparation for skin and application thereof |
-
2014
- 2014-08-29 CN CN201410436054.2A patent/CN104146925B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012101638A2 (en) * | 2011-01-24 | 2012-08-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Nanoparticles for cosmetic applications |
| CN103622864A (en) * | 2013-01-30 | 2014-03-12 | 广东雅丽洁精细化工有限公司 | Multifunctional aloe gel and preparation method thereof |
| CN103536476A (en) * | 2013-10-17 | 2014-01-29 | 苏州威尔德工贸有限公司 | Grape seed oil skin protection cream and preparation method thereof |
| CN104000757A (en) * | 2014-05-26 | 2014-08-27 | 乌鲁木齐阿芙罗商贸有限公司 | External preparation for skin and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵琼: "《我的美丽处方》", 30 November 2011, 漓江出版社 * |
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