CN105125420B - It is a kind of to be used to alleviate drug gel system of conventional transdermal problem and preparation method thereof - Google Patents
It is a kind of to be used to alleviate drug gel system of conventional transdermal problem and preparation method thereof Download PDFInfo
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- CN105125420B CN105125420B CN201510648903.5A CN201510648903A CN105125420B CN 105125420 B CN105125420 B CN 105125420B CN 201510648903 A CN201510648903 A CN 201510648903A CN 105125420 B CN105125420 B CN 105125420B
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- 239000003814 drug Substances 0.000 title claims abstract description 62
- 229940079593 drug Drugs 0.000 title claims abstract description 61
- 238000002360 preparation method Methods 0.000 title claims description 19
- 230000001815 facial effect Effects 0.000 claims abstract description 42
- 229920001661 Chitosan Polymers 0.000 claims abstract description 40
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 31
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 29
- 239000004615 ingredient Substances 0.000 claims abstract description 21
- 229920001436 collagen Polymers 0.000 claims abstract description 18
- 102000008186 Collagen Human genes 0.000 claims abstract description 12
- 108010035532 Collagen Proteins 0.000 claims abstract description 12
- 238000010521 absorption reaction Methods 0.000 claims abstract description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 27
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 11
- 230000003020 moisturizing effect Effects 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 230000002087 whitening effect Effects 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 229940069521 aloe extract Drugs 0.000 claims description 6
- 230000001153 anti-wrinkle effect Effects 0.000 claims description 6
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 5
- 206010000496 acne Diseases 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 241001474374 Blennius Species 0.000 claims description 4
- 235000012907 honey Nutrition 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 241000628997 Flos Species 0.000 claims description 3
- 240000003553 Leptospermum scoparium Species 0.000 claims description 3
- 235000015459 Lycium barbarum Nutrition 0.000 claims description 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 3
- 229930003537 Vitamin B3 Natural products 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000005374 membrane filtration Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229960003512 nicotinic acid Drugs 0.000 claims description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 3
- 230000010355 oscillation Effects 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 230000002459 sustained effect Effects 0.000 claims description 3
- 235000019160 vitamin B3 Nutrition 0.000 claims description 3
- 239000011708 vitamin B3 Substances 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 239000000341 volatile oil Substances 0.000 claims description 3
- 241001116389 Aloe Species 0.000 claims description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 2
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 2
- 241001313857 Bletilla striata Species 0.000 claims description 2
- 241000555682 Forsythia x intermedia Species 0.000 claims description 2
- 244000131316 Panax pseudoginseng Species 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
- 244000082204 Phyllostachys viridis Species 0.000 claims description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 2
- 235000011399 aloe vera Nutrition 0.000 claims description 2
- 230000003255 anti-acne Effects 0.000 claims description 2
- 239000011425 bamboo Substances 0.000 claims description 2
- 239000003610 charcoal Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 235000008434 ginseng Nutrition 0.000 claims description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000004745 nonwoven fabric Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 description 61
- 239000000243 solution Substances 0.000 description 22
- 239000002657 fibrous material Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000005808 skin problem Effects 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000006196 deacetylation Effects 0.000 description 2
- 238000003381 deacetylation reaction Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000001112 coagulating effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000850 deacetylating effect Effects 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Chemical group 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229920001427 mPEG Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
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- A61Q19/08—Anti-ageing preparations
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- Cosmetics (AREA)
Abstract
A kind of drug gel system for being used to alleviate conventional transdermal problem, including gel layer and supporting layer, which is characterized in that the gel layer absorption is on the supporting layer, and gel layer is outer layer two layers, and supporting layer is located at centre；Be weight percentage 3.0% 3.5% chitosan, 3.0% 3.5% mono methoxy polyethylene glycols and 0.01% 0.1% collagens, the gel layer of the gel layer contains various effective ingredients.Drug gel system of the present invention is mainly used for alleviating skin of face general issues, can be made into the membranaceous shape suitable for arbitrary skin of face, and such as face is whole, nose facial mask, eye facial mask etc..The drug gel system has temperature-sensing property, can well adapt to skin temperature, forms gel mask, reaches and alleviates conventional transdermal problem purpose.
Description
Technical field
The invention belongs to cosmetic mask fields, specifically, are asked the invention discloses one kind for alleviating conventional transdermal
Drug gel system of topic and preparation method thereof.
Background technology
Face's face is the position that human body most can directly express Mai Tai, and facial facial skin is very big by outside contamination, easily
By the pollution of the gas such as extraneous foul atmosphere etc., water shortage is dried so as to cause face skin, oxidation of overrunning, inflammation play acne, for face
For portion's skin problem there is typically further fuel-displaced more, the colour of skin is burned black, there is the various problems such as wrinkle.For conventional skin problem, especially
It is the skin problem for face, is usually all solved by various cosmetic products, therefore, people usually pay close attention to the beauty of face,
In the cosmetics used in face, facial mask is a kind of very common facial cosmetic product and presently, there are various makeups
Product, facial mask are one kind therein..
Chitosan (chitosan) is a kind of deacetylated derivative of chitin, is that a large amount of existing alkalescence of nature are more
Sugar, bio-toxicity is small, has good histocompatbility, biodegradability and adhesion, but under normal circumstances, chitosan
It is dissolved only in acidic aqueous solution, the precipitation of similar gels, and the process and temperature relation can be formed in neutral or alkaline solution
Less.But Recent study is found, anti-by adding in basic salt, hydroxyl polymer-containing or chitosan being performed the derivatization and is grafted
Should, the chitosan-based physical gel with temperature sensitivity can be obtained.Solution keeps solution shape in physiological pH (7.0) and at room temperature
State, and the rapid gellation when temperature rises to body temperature (37 DEG C).Presently, there are have chitosan being applied to the special of cosmetic field
Sharp technology.
Mono methoxy polyethylene glycol (Methoxy Polyethylene Glycol, mPEG) has good water-soluble, profit
Moist, lubricity, physiological inertia, non-stimulated to human body, mild, molecular weight 2KD extensive in cosmetic applications.In chitosan
Acid solution in add in suitable mono methoxy polyethylene glycol will not neutralize the proton of chitosan at once and make chitosan precipitate under
Come, the pH value of chitosan solution can be made to rise to physiological range i.e. pH7.0 or so.Under cryogenic, the effect of chitosan and water
Prevent the aggregation of chitosan chain；When temperature raises, (effect can weaken for the structuring effect of mono methoxy polyethylene glycol and water
The effect of chitosan and water) strengthen, it is dehydrated chitosan chain, the region of hydrone is substituted by the hydroxy groups of polyethylene glycol, shell
Glycan chain aggregation.
Although in the presence of the patent that chitosan is applied to facial mask field, not by chitosan and the poly- second two of mono methoxy
The inventional idea that the effective medicinal components such as alcohol and moisturizing, anti-wrinkle and whitening in other facial masks combine.
The present invention is using the temperature sensitive of chitosan and mono methoxy polyethylene glycol gel and is contained within effective medicinal components
Slow releasing function, prepare one kind can effective moisturizing, and relatively slowly release effective medicinal components improve skin problem for delaying
The drug gel system of conventional transdermal problem is solved, especially a kind of drug gel system for alleviating conventional skin of face problem.
The content of the invention
Thermo-sensitive facial mask effect to solve the prior art, which is paid no attention to, to be thought of effective medicinal components in facial mask and is rationally released effectively
The problem of effective medicinal components, provides a kind of drug gel system for being used to alleviate conventional transdermal problem.
The invention discloses a kind of for alleviating the drug gel system of conventional transdermal problem, including gel layer and support
Layer, which is characterized in that on the supporting layer, the gel layer is weight percentage 3.0%-3.5% for gel layer absorption
Chitosan, 3.0%-3.5% mono methoxy polyethylene glycols and 0.01%-0.1% collagens, the gel layer contains respectively
Kind effective medicinal components.
Further, the various effective medicinal components be with whitening or/and moisturizing or/and anti-acne or/and oil-control or/and
At least one of the drug or/and Chinese medical extract ingredient of anti-wrinkle or/and other functions.It can be asked for different skin of face
The one or more effective medicinal components of topic selection prepare different gel systems.
Further, described drug or/and Chinese medical extract ingredient with whitening function to be arbitrary with whitening function
Drug or/and Chinese medical extract, wherein preferably vitamin B3, vitamin C and its derivative, aloe extract, ursin,
Pearl powder.
Further, the drug or/and Chinese medical extract ingredient with moisture-keeping functions is arbitrarily with moisture-keeping functions
Drug or/and Chinese medical extract, wherein preferably seaweed elite, honey, natural moisturizing factor, pollen pini.
Further, it is described that there is the drug of oil-control or/and Chinese medical extract ingredient for arbitrarily there is oil-control
Drug or/and Chinese medical extract, wherein preferably bamboo charcoal, radix polygonati officinalis extract liquor, aloe extract, forsythia suspense extraction.
Further, the drug or/and Chinese medical extract ingredient with acne-removal function is arbitrarily with acne-removal functions
Drug or/and Chinese medical extract, wherein preferably Honegsukle flower P.E, Flos Chrysanthemi Indici extract, tea tree ethereal oil, aloe extract,
SEMEN COICIS powder.
Further, it is described that there is the drug of anti-wrinkle or/and Chinese medical extract ingredient for arbitrarily there is anti-wrinkle
Drug or/and Chinese medical extract, wherein preferably ginseng, Ganodenna Lucidum P.E, Radix Ophiopogonis, the bletilla striata.
Further, it is described to be mainly used for improving the normal of skin of face for alleviating the drug gel system of conventional transdermal problem
Rule problem.
Further, the material that the supporting layer uses for non-woven fabrics, breathable polymeric membrane or biological fiber etc., wherein it is preferred that
For biological fibrous material, skin has better adaptability to supporting layer made of biological fibrous material.
Further, the shape of the supporting layer is applicable to the maintenance of arbitrary skin of face, can make eye facial mask, nose
Portion's facial mask, whole facial mask shape etc..
Further, the shape of the supporting layer is consistent with shape of face, and opening, the shape of supporting layer are set at mouth, eye, nose
Have that shape of face is consistent, can make it is facial it is whole maintained, at button, eye, nose setting perforate can have the ingredient in preventing gel
Into inside of human body, damage.
Include procedure below for alleviating the preparation method of the drug gel system of conventional transdermal problem：
1) preparation of mono methoxy polyethylene glycol solution：Mono methoxy polyethylene glycol is weighed, is dissolved in distilled water, vibration stirring
Sustained oscillation on device, makes it thoroughly dissolve, and concentration is made as 30% mono methoxy polyethylene glycol solution (w/v), membrane filtration is low
Temperature stores for future use；
2) preparation of chitosan solution：Chitosan solution is prepared using acetic acid, by the chitosan solution of acquisition after stirring 2 days
After autoclave sterilization, used after being cooled to room temperature；
3) preparation of effective medicinal components-collagen solution：Collagen is dissolved in sodium hydroxide, and adjusts pH value to 7.0-
7.4, then effective medicinal components is added to make its dissolving；
4) preparation of chitosan-mono methoxy polyethylene glycol gel：After three kinds of solution ice bath 30min, chitosan is drawn
Acetum is into container, and after effective medicinal components-collagen solution is added dropwise, the poly- second of mono methoxy is added dropwise simultaneously in quick stirring
Glycol solution, and continue to stir 20min.It is medicinal effective in the drug gel system for being used to alleviate conventional transdermal problem obtained
The concentration of ingredient is 10-5-10-4M, chitosan mass concentration is 3.0%-3.5%, and mono methoxy polyethylene glycol concentration is
3.0%-3.5%, the concentration of collagen are 0.01%-0.1%；
5) original supporting layer is put into liquid prepared by step 4, impregnated；
6) after impregnating, the supporting layer with gel layer is put into facial mask mold, the facial mask of designated shape is made.
The present invention is for alleviating the drug gel system of conventional transdermal problem, into the liquid absorption of moistening under normal temperature condition
On supporting layer, facilitate attaching and on the face, the gelation when close to body temperature effectively moisturizing and can slowly discharge medicinal effective
Ingredient.
Description of the drawings
Fig. 1 drug gel system facial mask positive structure diagrams；
Fig. 2 drug gel system facial mask left view structural representations；
In figure, 1, gel layer；2nd, supporting layer
Embodiment 1 is used to alleviate the preparation method of the drug gel system of conventional transdermal problem
Preparation method for alleviating the drug gel system of conventional transdermal problem is：
1. the measure of deacetylating degree of chitosan：It is measured with elemental analyser, using CHN S modes, measures material respectively and use
The constituent content of CHN, calculates the deacetylation of chitosan, its deacetylation of the results show is 90%.
2. the preparation of mono methoxy polyethylene glycol solution：Mono methoxy polyethylene glycol is weighed, is dissolved in distilled water, vibration stirring
Sustained oscillation on device, makes it thoroughly dissolve, and concentration is made as 30% mono methoxy polyethylene glycol solution (w/v), membrane filtration is low
Temperature stores for future use.
3. the preparation of chitosan solution：Chitosan solution is prepared using acetic acid, by the chitosan solution of acquisition after stirring 2 days
After autoclave sterilization, used after being cooled to room temperature.
4. the preparation of effective medicinal components-collagen solution：Collagen is dissolved in sodium hydroxide, and adjusts pH value to 7.0-
7.4, adding effective medicinal components makes its dissolving.
5. the preparation of chitosan-mono methoxy polyethylene glycol gel：After three kinds of solution ice bath 30min, chitosan is drawn
Acetum is into container, and after effective medicinal components-collagen solution is added dropwise, the poly- second of mono methoxy is added dropwise simultaneously in quick stirring
Glycol solution, and continue to stir 20min.Effective medicinal components-chitosan-mono methoxy polyethylene glycol gel systems of acquisition
In, the concentration of effective medicinal components is 10-5-10-4M, chitosan mass concentration be 3.0%-3.5%, mono methoxy polyethylene glycol
Concentration is 3.0%-3.5%, 0.01%-0.1% collagen.
6. original supporting layer is put into liquid prepared by step 4, impregnate.
7. after impregnating, the supporting layer with gel layer is put into facial mask mold, the facial mask of designated shape is made.
Embodiment 2 is used to alleviate the drug gel system facial mask of conventional transdermal problem
A kind of medicinal facial mask is used to alleviate the drug gel system of conventional transdermal problem, is specially a kind of whitening mask, wraps
Gel layer 1 and supporting layer 2 are included, gel layer is adsorbed on supporting layer, and gel layer 1 is outside two layers, and supporting layer 2 is located at centre；It is solidifying
Glue-line 1 be weight percentage 3.0% chitosan, 3.0% mono methoxy polyethylene glycol and 0.01% collagen, gel layer
In have whitening function drug or/and Chinese medical extract, be specially vitamin B3, vitamin C and its derivative, aloe, bear
Fruit glycosides.Seaweed elite, honey, the one or more of natural moisturizing factor.
Supporting layer 2 uses biological fibrous material, and facial skin has supporting layer made of biological fibrous material preferably suitable
Ying Xing.The shape of supporting layer 2 is consistent with shape of face, and opening is set at mouth, eye, nose, and the shape of supporting layer has that shape of face is consistent, can
It is maintained so that face is whole, setting perforate that can have at mouth, eye, nose prevents the ingredient in gel from entering inside of human body,
It damages.
Embodiment 3 is used to alleviate the drug gel system facial mask of conventional transdermal problem
A kind of medicinal facial mask is used to alleviate the drug gel system of conventional transdermal problem, is specially a kind of moisture saver mask, wraps
Gel layer 1 and supporting layer 2 are included, gel layer is adsorbed on supporting layer, and gel layer 1 is outside two layers, and supporting layer 2 is located at centre；It is solidifying
Glue-line 1 be weight percentage 3.5% chitosan, 3.5% mono methoxy polyethylene glycol and 0.1% collagen, gel layer
In there is the drug or/and Chinese medical extract of moisture-keeping functions, be specially seaweed elite, honey, natural moisturizing factor, pollen pini
It is one or more.
Supporting layer 2 uses biological fibrous material, and facial skin has supporting layer made of biological fibrous material preferably suitable
Ying Xing.The shape of supporting layer 2 is consistent with shape of face, and opening is set at mouth, eye, nose, and the shape of supporting layer has that shape of face is consistent, can
It is maintained so that face is whole, setting perforate that can have at mouth, eye, nose prevents the ingredient in gel from entering inside of human body,
It damages.
Embodiment 4 is used to alleviate the drug gel system facial mask of conventional transdermal problem
A kind of medicinal facial mask is used to alleviate the drug gel system of conventional transdermal problem, is specially a kind of Deacne pack, wraps
Gel layer 1 and supporting layer 2 are included, gel layer is adsorbed on supporting layer, and gel layer 1 is outside two layers, and supporting layer 2 is located at centre；It is solidifying
Glue-line 1 be weight percentage 3.2% chitosan, 3.2% mono methoxy polyethylene glycol and 0.05% collagen, gel layer
At least one containing various whitenings, anti-inflammatory, moisturizing ingredient or/and other nutritional ingredients.Gel layer has the drug of acne-removal function
Or/and Chinese medical extract, it is specially Honegsukle flower P.E, Flos Chrysanthemi Indici extract, tea tree ethereal oil, aloe extract, SEMEN COICIS powder
It is one or more.
Supporting layer 2 uses biological fibrous material, and facial skin has supporting layer made of biological fibrous material preferably suitable
Ying Xing.The shape of supporting layer 2 is consistent with shape of face, and opening is set at mouth, eye, nose, and the shape of supporting layer has that shape of face is consistent, can
It is maintained so that face is whole, setting perforate that can have at mouth, eye, nose prevents the ingredient in gel from entering inside of human body,
It damages.
Embodiment 5 is used to alleviate the drug gel system facial mask skin irritation evaluation of conventional transdermal problem
Experiment material
40 healthy womens found at random, 2,3,4 facial mask of circular embodiment of a diameter of 10mm sizes of sufficient amount
Experimental method
By the rounded face diaphragm of diameter 10mm, be attached to the Medial upper arm of 40 healthy womens and maintain 24 it is small when after shell
From observing by the naked eye skin condition, evaluated according to following evaluation criteria.
1:Non-stimulated 2:It is weak to stimulate 3:Erythema 4:Erythema and edema 5:Erythema, edema and bubble
Experimental result
As a result the skin as 2,3,4 drug gel system facial mask of embodiment is placed in the display of table one finds no irritation, mistake
Phenomena such as quick, all to be nonirritant as a result, illustrating that the facial mask can be applied on human facial skin.
The skin irritatin degree of one each embodiment of table
Embodiment 6 is used to alleviate the drug gel system facial mask moistening effect evaluation of conventional transdermal problem
Experiment material
40 healthy womens found at random, the 3 drug gel system of circular embodiment of a diameter of 20mm sizes of sufficient amount
System facial mask, conventional creams gel mask.
Experimental method
It, will after measuring 3 drug gel system facial mask of diameter 20mm embodiments and conventional creams gel mask initial weight
It is attached to the Medial upper arm of 40 healthy womens and maintains 30 minutes, then removes and measures its weight, poor so as to calculate it
Value.Moisture evaporation in order to prevent covers it same plastics of size and fixation.Using to percutaneous moisture loss amount
The device i.e. TewarmeterTM210 that (transepidermalwaterloss, hereinafter referred to as TEWL) is measured
(Courageandkhazaka companies, Germany) measures moisture loss amount (g/m2h).40 subjects are carried out respectively above-mentioned
It measures, the average value of the value obtained from them is obtained.
Experimental result
If table two is shown, percutaneous moisture loss shows significantly low measured value, can confirm and coagulating using conventional emulsion
Glue surface film is compared, and the skin moisture-keeping power using the 3 drug gel system facial mask of embodiment is more superior.
Two moistening effect situation of table
| 3 drug gel system facial mask of embodiment | Conventional creams gel mask | |
| The difference of weight (g) | 0.45 | It can not measure |
The explanation for stating embodiment is only intended to understand the present invention.It should be pointed out that come for those of ordinary skill in the art
It says, without departing from the principle of the present invention, several improvement can also be carried out to the present invention, these improvement will also fall into this hair
In bright scope of the claims.
Claims (10)
1. it is a kind of for alleviating the drug gel system of conventional transdermal problem, including gel layer and supporting layer, which is characterized in that institute
Gel layer absorption is stated on the supporting layer, the gel layer is weight percentage chitosan, the 3.0%- of 3.0%-3.5%
3.5% mono methoxy polyethylene glycol and 0.01%-0.1% collagens, the gel layer contain various effective medicinal components.
2. the drug gel system according to claim 1 for being used to alleviate conventional transdermal problem, which is characterized in that described each
Kind effective medicinal components are to have the function of whitening or/and moisturizing or/and anti-acne or/and oil-control or/and anti-wrinkle or/and other medicine
At least one of object or/and Chinese medical extract ingredient.
3. the drug gel system according to claim 2 for being used to alleviate conventional transdermal problem, which is characterized in that described
Drug or/and Chinese medical extract ingredient with whitening function for vitamin B3, vitamin C and its derivative, aloe extract,
Ursin, pearl powder.
4. the drug gel system according to claim 2 for being used to alleviate conventional transdermal problem, which is characterized in that the tool
Drug or/and the Chinese medical extract ingredient for having moisture-keeping functions are seaweed elite, honey, natural moisturizing factor, pollen pini.
5. the drug gel system according to claim 2 for being used to alleviate conventional transdermal problem, which is characterized in that the tool
Drug or/and the Chinese medical extract ingredient for having oil-control function are bamboo charcoal, radix polygonati officinalis extract liquor, aloe extract, forsythia suspense extraction.
6. the drug gel system according to claim 2 for being used to alleviate conventional transdermal problem, which is characterized in that the tool
It is Honegsukle flower P.E, Flos Chrysanthemi Indici extract, tea tree ethereal oil, aloe to have the drug of acne-removal function or/and Chinese medical extract ingredient
Extract, SEMEN COICIS powder.
7. the drug gel system according to claim 2 for being used to alleviate conventional transdermal problem, which is characterized in that the tool
It is ginseng, Ganodenna Lucidum P.E, Radix Ophiopogonis, the bletilla striata to have the drug of anti-wrinkle function or/and Chinese medical extract ingredient.
8. the drug gel system according to claim 1 for being used to alleviate conventional transdermal problem, which is characterized in that the branch
The material that support layer uses is non-woven fabrics, breathable polymeric membrane or biological fiber.
9. the drug gel system according to claim 1 for being used to alleviate conventional transdermal problem, which is characterized in that the branch
It is consistent with shape of face to support the shape of layer, and opening is set at mouth, eye, nose.
10. it is described in claim 1 for alleviating the preparation method of the drug gel system of conventional transdermal problem, including following
Process：
1) preparation of mono methoxy polyethylene glycol solution：Mono methoxy polyethylene glycol is weighed, is dissolved in distilled water, on oscillating agitator
Sustained oscillation makes it thoroughly dissolve, and concentration is made as 30% mono methoxy polyethylene glycol solution (w/v), membrane filtration, low temperature storage
It deposits spare；
2) preparation of chitosan solution：Chitosan solution is prepared using acetic acid, by the chitosan solution high temperature of acquisition after stirring 2 days
After autoclave sterilization, used after being cooled to room temperature；
3) preparation of active ingredient-collagen solution：Collagen is dissolved in sodium hydroxide, and adjusts pH value to 7.0-7.4, then dosing
Make its dissolving with active ingredient；
4) preparation of chitosan-mono methoxy polyethylene glycol gel：After three kinds of solution ice bath 30min, chitosan acetic acid is drawn
Solution is into container, and after effective medicinal components-collagen solution is added dropwise, mono methoxy polyethylene glycol is added dropwise simultaneously in quick stirring
Solution, and continue to stir 20min；In the drug gel system for being used to alleviate conventional transdermal problem obtained, effective medicinal components
Concentration be 10-5-10-4M, chitosan mass concentration is 3.0%-3.5%, and mono methoxy polyethylene glycol concentration is 3.0%-
3.5%th, 0.01%-0.1% collagens；
5) original supporting layer is put into liquid prepared by step 4, impregnated；
6) after impregnating, the supporting layer with gel layer is put into facial mask mold, the facial mask of designated shape is made.
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| JP6853994B2 (en) * | 2016-04-28 | 2021-04-07 | コスメディ製薬株式会社 | Cosmetic alcogel sheet and its manufacturing method |
| CN106074217B (en) * | 2016-06-01 | 2019-03-05 | 南京天朗制药有限公司 | Body temperature is moulded into type skin caring material and skin nursing film and preparation method certainly |
| CN107095835A (en) * | 2017-04-06 | 2017-08-29 | 安徽安龙基因医学检验所有限公司 | A kind of wild ginseng stem cell emulsus facial mask and preparation method |
| CN109481737B (en) * | 2017-09-12 | 2021-07-06 | 中国人民解放军第三军医大学第一附属医院 | Bionic double-layer dressing and preparation method thereof |
| CN110051691A (en) * | 2018-01-15 | 2019-07-26 | 张家港蓝智生物科技有限公司 | A kind of epoxy resin and cold compress patch having white-skinned face function |
| CN111437221A (en) * | 2019-01-16 | 2020-07-24 | 北京大学 | Mite-removing free radical hydrogel mask |
| CN109602686A (en) * | 2019-02-02 | 2019-04-12 | 西安力邦制药有限公司 | A kind of aqueous gelled cosmetic compositions and preparation method thereof |
| CN112315893B (en) * | 2020-12-08 | 2023-06-23 | 安徽芨智生物科技有限公司 | Beauty cream mask with whitening and moisturizing effects and preparation method thereof |
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