CN102988257A - Liposome sun-screening skin care product - Google Patents
Liposome sun-screening skin care product Download PDFInfo
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- CN102988257A CN102988257A CN2012105242277A CN201210524227A CN102988257A CN 102988257 A CN102988257 A CN 102988257A CN 2012105242277 A CN2012105242277 A CN 2012105242277A CN 201210524227 A CN201210524227 A CN 201210524227A CN 102988257 A CN102988257 A CN 102988257A
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Abstract
The invention relates to a liposome sun-screening skin care product, belonging to the technical field of cosmetics. The liposome sun-screening skin care product comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 10.0-10,000.0 parts of hyaluronic acid, 0.003-3000.0 parts of phospholipid, 0.001-10.0 parts of metallothionein, 0.001-10.0 parts of collagen, 10.0-5000.0 parts of water-soluble pearl powder the weight percentage of which is 20%, and 0.001-200.0 parts of cholesterol. The sun-screening skin care product provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The liposome sun-screening skin care product can deeply humidify horny cells and enhance hydration to improve the skin softness, and can provide sufficient nutrients to ensure skin health and increase skin resistance.
Description
Technical field
The present invention relates to a kind of liposome sunlight screening skin-protecting product, relate in particular to and a kind ofly can solve that skin is intensely dark, flexibility decrease, aging problem, and the good liposome sunlight screening skin-protecting product of sun-proof result, the cosmetic product technical field belonged to.
Background technology
Skin is comprised of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe by three approach.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in the daily life, most skin care milks are aqueous solutions, the superficial growth factor, protein, aminoacid, barbaloin, the important life active compound such as vitamin C all is water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity skin care item utilization rate very little, for a long time use the water solublity skin care item, cause easily the nutritional labeling waste and stop up easily pore.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention provides a kind of liposome sunlight screening skin-protecting product, it is take liposome as carrying China, various nutritional labelings are carried to deep skin, fully absorbed by human body, these skin care item can solve that skin is intensely dark, flexibility decrease, aging problem, and sun-proof result is good.
For realizing described goal of the invention, a kind of liposome sunlight screening skin-protecting product of the present invention, it comprises the composition of following ratio of weight and number:
Preferably, it also comprises the composition of following ratio of weight and number:
Compared with prior art, liposome sunlight screening skin-protecting product provided by the invention, it is take liposome as carrying China, various nutritional labelings are carried to deep skin, fully absorbed by human body, this sunlight screening skin-protecting product can solve that skin is intensely dark, flexibility decrease, aging problem, and sun-proof result is good.
Description of drawings
Fig. 1 is the sketch map of the skin absorption process of the skin care item that provide in the prior art;
Fig. 2 is the sketch map of the skin absorption process of liposome sunlight screening skin-protecting product provided by the invention.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
This embodiment provides a kind of can solve that skin is intensely dark, flexibility decrease, aging problem, and skin care item that can be sun-proof.The described lipid sunlight screening skin-protecting product of recuperating comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SCGF) | 0.01-0.1 |
| Hyaluronic acid | 10.0-10,000.0 |
| Phospholipid | 0.003-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Percentage by weight is 20% Margarita powder aqueous solution | 10.0-5000.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome sunlight screening skin-protecting product that this embodiment provides is: 100mg phospholipid and 25mg cholesterol are dissolved in the 30ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 2000mg hyaluronic acid, 5mg metallothionein and 5mg collagen protein are dissolved in the 40ml deionized water (perhaps aqueous phosphatic PH=6.8) and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then be that 20% Margarita powder aqueous solution adds in the above-mentioned eggplant-shape bottle with above-mentioned aqueous solution II and 1000mg percentage by weight, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome sunlight screening skin-protecting product of an epidermal growth factor, human stem cell growth, hyaluronic acid, metallothionein, collagen protein and Margarita active ingredient etc.
Fig. 2 is the sketch map of the skin absorption process of liposome sunlight screening skin-protecting product provided by the invention.As shown in Figure 2, because it is similar to human body cell outer membrane structure and composition to seal the liposome adventitia of nutritional labeling, so gap and the direct transdermal of skin subsidiary pipeline opening that complete liposome can pass between horn cell, the horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in the double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome phospholipid and Stratum corneum lipids merge changes the horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure, by the lipid granule gap, liposomal encapsulated medicine or nutritional labeling just enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in the human body metabolism, keep one of necessary basic substance of human normal physiological function, have targeting as pharmaceutical carrier, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity; be applicable to biological vivo degradation; can protect the entrapped superficial growth factor and human stem cell growth etc., and can carry the nutritional labelings such as the superficial growth factor and human stem cell growth and pass horny layer and enter corium and subcutaneous tissue.Alleviation, the controlled release superficial growth factor and human stem cell growth etc. in corium and subcutaneous tissue.Because liposome has targeting, can improve the superficial growth factor and metallothionein etc. in the bioavailability of skin.
The liposome sunlight screening skin-protecting product of sealing epidermal growth factor, human stem cell growth, metallothionein, collagen protein and Margarita active ingredient is on probation through 100 Mies of 30 years old to 45 years old, after 20 days, 90% people's wrinkle reduces, skin is bright and clean moistens, increased elasticity, and whitening effect is good.
Embodiment 2
This embodiment provides a kind of and solves that skin is intensely dark, flexibility decrease, aging problem, can be sun-proof and the liposome sunlight screening skin-protecting product of the skin care item of moisturizing.Described liposome sunlight screening skin-protecting product comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Vascular endothelial cell growth factor (VEGF) | 0.05-8.0 |
| Hyaluronic acid | 10.0-10,000.0 |
| Human stem cell growth | 0.01-0.1 |
| Phospholipid | 0.003-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Elastin laminin | 0.001-10.0 |
| Fibrous protein | 0.001-10.0 |
| Percentage by weight is 20% pearl water solution | 0.1-5000.0 |
| Barbaloin | 0.001-100.0 |
| Aminoacid | 0.001-10.0 |
| Vitamin E | 0.001-1000.0 |
| Vitamin C | 0.001-1000.0 |
| Licoflavone | 0.01-500.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome sunlight screening skin-protecting product that this embodiment provides is: 100mg phospholipid, 25mg vitamin E, 10mg licoflavone and 25mg cholesterol are dissolved in the 40ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing the 3.0mg epidermal growth factor, 0.05mg human stem cell growth (SCGF) (available from Peprotech company), 1mg vascular endothelial cell growth factor (VEGF), the 1000mg hyaluronic acid, the 5mg metallothionein, the 5mg collagen protein, the 5mg elastin laminin, the 5mg fibrous protein, the 20mg barbaloin, 5mg aminoacid and 25mg vitamin C are dissolved in the 70ml deionized water (perhaps aqueous phosphatic PH=6.8) and are constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then be that 20% Margarita powder hydrolyzed solution adds in the above-mentioned eggplant-shape bottle with above-mentioned aqueous solution II and 1000mg percentage by weight, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying an epidermal growth factor, human stem cell growth (SCGF), vascular endothelial cell growth factor (VEGF), metallothionein, collagen protein, elastin laminin, fibrous protein, barbaloin, aminoacid, vitamin E, the liposome sunlight screening skin-protecting product of vitamin C and Margarita active ingredient etc.
Liposome can be protected the nutritional labelings such as entrapped epidermal growth factor, SCGF (available from Peprotech company) to pass horny layer and enter corium and subcutaneous tissue, is fully absorbed and utilizes.
After 10 days on probation, 98% people's skin light on the face is gorgeous moist, pale through 100 Mies of 35 years old to 45 years old for the liposome face nourishing skin care products that present embodiment is produced, and elasticity strengthens, wrinkle reduces.After 30 days, 99% people's wrinkle is almost eliminated, skin is bright and clean moist, pale, and skin elasticity strengthens greatly, and will have a competition with the front obvious youth that seems.
In addition, can liposome and solution separating be opened with the SephadexG50 chromatographic column if need.
Liposome sun-proof skin care articles for use provided by the invention are the high-tech carrier for active principle in a kind of tip, consisted of by the phospholipid bimolecular, include the miniature vesicle of water purification, the human stem cell growth (SCGF) that the internal energy encapsulation of vesicle is quantitative, hyaluronic acid, metallothionein, collagen protein, elastin laminin, fibrous protein, barbaloin, aminoacid, vitamin E, the nutritional labelings such as vitamin C and Margarita active ingredient, its average diameter is 100 nanometers, it is 1/200～1/300 of human body cell diameter, can penetrate easily the human body skin top layer, with cell fusion, the performance effect.Therefore, liposome sun-proof skin care articles for use provided by the invention can promote cell regeneration, solve the dim light of skin, flexibility decrease and aging problem and have good skin care effect, can go deep into the humidifying horn cell and strengthen hydration improving the flexibility of skin, thereby can repair the normal physiological function that the cell that damage is arranged is safeguarded skin; Can provide enough nutrient to guarantee the health of skin, strengthen skin resistance; Have superpower moist moisture-keeping functions, the deep layer moisturizing improves the dry water shortage status of skin; Also has anti-sunlight function.
The effect that below describes in conjunction with the embodiments component of the present invention, preparation method in detail and reach, but the embodiment instrument is for the explanation the present invention of demonstration ground.Description only is for explaining claims.But protection scope of the present invention is not limited to description.Any those skilled in the art of being familiar with are in the technical scope that the present invention discloses, and the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (2)
1. liposome sunlight screening skin-protecting product, it comprises the composition of following ratio of weight and number:
2. liposome sunlight screening skin-protecting product according to claim 1, it also comprises the composition of following ratio of weight and number:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210524227.7A CN102988257B (en) | 2012-12-10 | 2012-12-10 | Liposome sun-screening skin care product |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524227.7A CN102988257B (en) | 2012-12-10 | 2012-12-10 | Liposome sun-screening skin care product |
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| CN102988257A true CN102988257A (en) | 2013-03-27 |
| CN102988257B CN102988257B (en) | 2015-03-04 |
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| CN201210524227.7A Expired - Fee Related CN102988257B (en) | 2012-12-10 | 2012-12-10 | Liposome sun-screening skin care product |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103276002A (en) * | 2013-05-31 | 2013-09-04 | 吉林农业大学 | Oil body containing oil body protein and collagen fusion protein |
| CN103505403A (en) * | 2013-09-29 | 2014-01-15 | 广州市娇兰化妆品有限公司 | Epidermal growth factor compound lipidosome as well as preparation method and application thereof |
| CN103989597A (en) * | 2014-05-04 | 2014-08-20 | 陈海 | Skin care mask and preparation method thereof |
| CN104306262A (en) * | 2014-10-18 | 2015-01-28 | 卢鹏 | Beauty mask |
| CN109394567A (en) * | 2018-10-19 | 2019-03-01 | 天津工业大学 | A kind of preparation method and quality testing standard of multifunctional transparent matter acid liposome |
| CN110664666A (en) * | 2019-11-06 | 2020-01-10 | 上海海洋大学 | Multi-effect cream for promoting skin fibroblasts to secrete structural proteins |
| WO2022232897A1 (en) * | 2021-05-03 | 2022-11-10 | Panag Pharma Inc. | Topical liposome polyphenol compositions for treating and preventing various skin disorders and methods of preparation thereof |
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| CN101278894A (en) * | 2008-05-23 | 2008-10-08 | 海南京润珍珠生物技术股份有限公司 | Sun cream containing liposome component of hydrolyzed pearl solution |
| CN102247300A (en) * | 2010-12-24 | 2011-11-23 | 天津天狮生物发展有限公司 | Human epidermal growth factor nanoliposome and its preparation method |
| CN102512370A (en) * | 2011-12-28 | 2012-06-27 | 广州赛莱拉生物科技有限公司 | HSCGF liposome as well as preparation and application thereof |
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2012
- 2012-12-10 CN CN201210524227.7A patent/CN102988257B/en not_active Expired - Fee Related
Patent Citations (3)
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| CN101278894A (en) * | 2008-05-23 | 2008-10-08 | 海南京润珍珠生物技术股份有限公司 | Sun cream containing liposome component of hydrolyzed pearl solution |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103276002A (en) * | 2013-05-31 | 2013-09-04 | 吉林农业大学 | Oil body containing oil body protein and collagen fusion protein |
| CN103505403A (en) * | 2013-09-29 | 2014-01-15 | 广州市娇兰化妆品有限公司 | Epidermal growth factor compound lipidosome as well as preparation method and application thereof |
| CN103505403B (en) * | 2013-09-29 | 2015-08-19 | 广州市娇兰化妆品有限公司 | Epidermal growth factor composite liposome body and its preparation method and application |
| CN103989597A (en) * | 2014-05-04 | 2014-08-20 | 陈海 | Skin care mask and preparation method thereof |
| CN104306262A (en) * | 2014-10-18 | 2015-01-28 | 卢鹏 | Beauty mask |
| CN109394567A (en) * | 2018-10-19 | 2019-03-01 | 天津工业大学 | A kind of preparation method and quality testing standard of multifunctional transparent matter acid liposome |
| CN110664666A (en) * | 2019-11-06 | 2020-01-10 | 上海海洋大学 | Multi-effect cream for promoting skin fibroblasts to secrete structural proteins |
| WO2022232897A1 (en) * | 2021-05-03 | 2022-11-10 | Panag Pharma Inc. | Topical liposome polyphenol compositions for treating and preventing various skin disorders and methods of preparation thereof |
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| Publication number | Publication date |
|---|---|
| CN102988257B (en) | 2015-03-04 |
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Granted publication date: 20150304 Termination date: 20181210 |