CN102988196B - Liposome hair growing preparation - Google Patents
Liposome hair growing preparation Download PDFInfo
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- CN102988196B CN102988196B CN201210524247.4A CN201210524247A CN102988196B CN 102988196 B CN102988196 B CN 102988196B CN 201210524247 A CN201210524247 A CN 201210524247A CN 102988196 B CN102988196 B CN 102988196B
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Abstract
The invention relates to a liposome hair growing cream, belonging to the technical field of cosmetics. The liposome hair growing cream comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 10.0-10,000.0 parts of hyaluronic acid, 0.003-3000.0 parts of phospholipid, 0.001-100.0 parts of vitamin H, 0.001-100.0 parts of ginkgetin, 0.001-10.0 parts of fibroin, 0.01-100.0 parts of collagen, and 0.001-200.0 parts of cholesterol. The liposome hair growing cream provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The liposome hair growing cream can deeply humidify horny cells and enhance hydration to improve the skin softness, can provide sufficient nutrients to ensure hair health and increase the flexibility and elasticity, and can promote hair regeneration.
Description
Technical field
The present invention relates to a kind of liposome hair-growing cream, relating in particular to a kind ofly can increase hair elasticity, pliability, and can make hair restoration liposome hair-growing cream, belongs to cosmetic product technical field.
Background technology
Skin is comprised of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance by three approach, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, for some macro-molecular proteins, can not directly absorb, in daily life, most hair-growing creams are aqueous solutions, and epidermal growth factor, collagen protein, ginkgetin, the important life active compound such as histidine is all water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity hair growth promoting composition utilization rate very little.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention is to provide a kind of liposome hair-growing cream, and it take liposome as carrying China, and various nutritional labelings are carried to deep skin, by human body, fully absorbed, can increase hair elasticity, pliability, also can make hair restoration.
For realizing described goal of the invention, a kind of liposome hair-growing cream, it comprises the composition of following ratio of weight and number:
Preferably, the composition that also comprises following ratio of weight and number:
Compared with prior art, liposome hair-growing cream provided by the invention, it take liposome as carrying China, and various nutritional labelings are carried to deep skin, by human body, is fully absorbed, and can increase hair elasticity, pliability, also can make hair restoration.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the skin absorption process of the skin care item that provide in prior art;
Fig. 2 is the schematic diagram of the skin absorption process of liposome hair-growing cream provided by the invention.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
This embodiment provides a kind of liposome hair-growing cream that increases hair elasticity, pliability, also can make hair restoration.Described liposome hair-growing cream comprises the composition of the weight part ratio described in following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SCGF) | 0.01-0.1 |
| Hyaluronic acid | 10.0-10,000.0 |
| Phospholipid | 0.003-3000.0 |
| Biotin | 0.001-100.0 |
| Ginkgetin | 0.001-100.0 |
| Fibroin | 0.001-10.0 |
| Collagen protein | 0.01-100.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome hair-growing cream that this embodiment provides is: 100mg phospholipid and 25mg cholesterol are dissolved in 30ml ethanol (or chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mgSCGF (purchased from Peprotech company), 500mg hyaluronic acid, 5mg fibroin, 5mg collagen protein, 25mg biotin and 25mg ginkgetin is dissolved in 40ml deionized water (or aqueous phosphatic PH=6.8) and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, spy formula Ultrasound Instrument makes the abundant aquation 20-120 minute of lipid membrane under ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome hair-growing cream of an epidermal growth factor, human stem cell growth, fibroin, collagen protein, biotin and ginkgetin.
Fig. 2 is the schematic diagram of the skin absorption process of liposome hair-growing cream provided by the invention.Similar to human body cell outer membrane structure and composition owing to sealing the liposome adventitia of nutritional labeling as shown in Figure 2, gap and the direct transdermal of skin subsidiary pipeline opening that therefore complete liposome can pass between horn cell, horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome phospholipid and Stratum corneum lipids merge changes horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure, by lipid granule gap, liposomal encapsulated medicine or nutritional labeling are convenient to enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in human body metabolism, maintain one of necessary basic substance of human normal physiological function, as pharmaceutical carrier, there is targeting, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity, be applicable to biological vivo degradation, can protect the entrapped superficial growth factor and metallothionein, and can carry the nutritional labelings such as the superficial growth factor and fibroin and enter corium and subcutaneous tissue through horny layer.The nutritional labeling such as alleviation, controlled release superficial growth factor in corium and subcutaneous tissue.Because liposome has targeting, can improve superficial growth factor etc. in the bioavailability of skin.
The liposome hair-growing cream that this truth example provides is on probation through 100 Mies of 30 years old to 45 years old, and after 20 days, 90% people's hair elasticity strengthens, pliability is good, and obviously no longer alopecia.
Embodiment 2
This embodiment provides a kind of liposome hair-growing cream that increases hair elasticity, pliability, also can make hair restoration.Described liposome hair-growing cream comprises the composition of the weight part ratio described in following table:
| Composition | Concrete content mg/L |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth | 0.01-0.1 |
| Hyaluronic acid | 10.0-10,000.0 |
| Lipoid | 0.001-1000.0 |
| Phospholipid | 0.003-3000.0 |
| Fatty acid | 0.001-1000.0 |
| Biotin | 0.001-100.0 |
| Ginkgetin | 0.001-100.0 |
| Fibroin | 0.001-10.0 |
| Collagen protein | 0.01-100.0 |
| Vitamin E | 0.001-200.0 |
| Vitamin C | 0.001-200.0 |
| Vitamin K | 0.001-200.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome hair-growing cream that this embodiment provides is: 100mg phospholipid, 100mg lipoid, 100mg fatty acid, 25mg cholesterol, 25mg vitamin E, 25mg vitamin K are dissolved in 40ml ethanol (or chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mgSCGF (purchased from Peprotech company), 500mg hyaluronic acid, 5mg fibroin, 5mg collagen protein, 20mg biotin, 20mg ginkgetin and 25mg vitamin C is dissolved in 50ml deionized water (or aqueous phosphatic PH=6.8) and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, spy formula Ultrasound Instrument makes the abundant aquation 20-120 minute of lipid membrane under ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome hair-growing cream of the compositions such as an epidermal growth factor, human stem cell growth.Preferably, described phospholipid is lecithin.
Liposome hair-growing cream in the present embodiment is on probation through 100 Mies of 20 years old to 45 years old, and after 10 days, 90% people's hair elasticity strengthens, pliability is good, and has obviously grown new.
In addition, if needed, can liposome and solution separating be opened with SephadexG50 chromatographic column.
Liposome hair-growing cream provided by the invention is the high-tech carrier for active principle in a kind of tip, by phospholipid bimolecular, formed, include the miniature vesicle of water purification, the nutritional labelings such as can encapsulation in vesicle quantitative epidermal growth factor, human stem cell, its average diameter is 100 nanometers, is 1/200～1/300 of human body cell diameter, can penetrate easily human body skin top layer, with cell fusion, performance effect.Therefore, liposome hair-growing cream provided by the invention is the natural nutriment of hair follicle development, both can be used for treating natural on-off cycles of hair growth and has grown the alopecia person who hinders, and also can be used as the daily indispensable nursing product of hair healthy adult, for delaying cell aging, prevent the generation of excessive alopecia, and it is new to grow.
The using method of liposome hair-growing cream provided by the invention:
1, after hair washing, this product is evenly spread upon on scalp and hair and stopped after 5 minutes, clear water is cleaned;
2 or temperature to bathe 10 minutes effects better; 3, consumption is too much unsuitable, with skin and hair, smears all and is as the criterion.
Below the effect that describes component of the present invention, preparation method in conjunction with the embodiments in detail and reach, but embodiment instrument is, for demonstrating, the present invention is described.Description instrument is for explaining claims.But protection scope of the present invention is not limited to description.In the technical scope that any those skilled in the art of being familiar with disclose in the present invention, the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (2)
1. the preparation method of a liposome anticreep hair cream, 100mg phospholipid and 25mg cholesterol are dissolved in 30ml ethanol or chloroform, methanol or dichloromethane, even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting 35 ℃ ± 1 ℃ of bath temperature, and pass into every now and then nitrogen, solvent removed by evaporation at reduced pressure, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mg human stem cell growth, 5mg fibroin, 5mg collagen protein, 20mg histidine, 25mg biotin and 25mg ginkgetin is dissolved in 40ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, use spy formula Ultrasound Instrument under ice-water bath condition, to make the abundant aquation 20-120 minute of lipid membrane, until that emulsion becomes is transparent.
2. the preparation method of a liposome anticreep hair cream, by phosphatidase 11 00mg, lipoid 100mg, fatty acid 100mg, 25mg vitamin E, 25mg vitamin K and cholesterol 25mg, be dissolved in 40ml ethanol or chloroform, methanol or dichloromethane, even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, 35 ℃ ± 1 ℃ of bath temperature, and pass into every now and then nitrogen, reduction vaporization desolventizes,, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mg human stem cell growth, 5mg fibroin, 5mg collagen protein, 20mg biotin, 20mg ginkgetin, 20mg histidine and 25mg vitamin C is dissolved in 50ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, use spy formula Ultrasound Instrument under ice-water bath condition, to make the abundant aquation 20-120 minute of lipid membrane, until that emulsion becomes is transparent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524247.4A CN102988196B (en) | 2012-12-10 | 2012-12-10 | Liposome hair growing preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524247.4A CN102988196B (en) | 2012-12-10 | 2012-12-10 | Liposome hair growing preparation |
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| Publication Number | Publication Date |
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| CN102988196A CN102988196A (en) | 2013-03-27 |
| CN102988196B true CN102988196B (en) | 2014-12-10 |
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| CN201210524247.4A Expired - Fee Related CN102988196B (en) | 2012-12-10 | 2012-12-10 | Liposome hair growing preparation |
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Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078138A (en) * | 1993-03-06 | 1993-11-10 | 青岛海洋大学 | Liquid for hair-growth |
| AUPP489798A0 (en) * | 1998-07-28 | 1998-08-20 | Mediko Pty Ltd | Hair growth/maintenance compositions and methods |
| US8178486B2 (en) * | 2005-07-21 | 2012-05-15 | Animal Technology Institute Taiwan | Method for promoting hair growth |
| CN101054579A (en) * | 2007-03-29 | 2007-10-17 | 上海复旦新杨生物科技有限责任公司 | A siRNA capable of preventing and curing hair loss and accelerating hair growth, and preparation method and application thereof |
| CN101313881A (en) * | 2007-05-29 | 2008-12-03 | 李燕强 | Shampoo composition redounding to hair generation |
| CN101199837A (en) * | 2007-11-30 | 2008-06-18 | 何荫良 | Humanized cell factor hair agent and preparing method thereof |
| CN102772324A (en) * | 2012-07-06 | 2012-11-14 | 南通帝星化工有限公司 | Anti-hair loss shampoo |
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