CN102988196A - Liposome hair growing preparation - Google Patents
Liposome hair growing preparation Download PDFInfo
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- CN102988196A CN102988196A CN2012105242474A CN201210524247A CN102988196A CN 102988196 A CN102988196 A CN 102988196A CN 2012105242474 A CN2012105242474 A CN 2012105242474A CN 201210524247 A CN201210524247 A CN 201210524247A CN 102988196 A CN102988196 A CN 102988196A
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Abstract
The invention relates to a liposome hair growing cream, belonging to the technical field of cosmetics. The liposome hair growing cream comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 10.0-10,000.0 parts of hyaluronic acid, 0.003-3000.0 parts of phospholipid, 0.001-100.0 parts of vitamin H, 0.001-100.0 parts of ginkgetin, 0.001-10.0 parts of fibroin, 0.01-100.0 parts of collagen, and 0.001-200.0 parts of cholesterol. The liposome hair growing cream provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The liposome hair growing cream can deeply humidify horny cells and enhance hydration to improve the skin softness, can provide sufficient nutrients to ensure hair health and increase the flexibility and elasticity, and can promote hair regeneration.
Description
Technical field
The present invention relates to a kind of liposome hair-growing cream, relating in particular to a kind ofly can increase hair elasticity, pliability, and can make hair restoration liposome hair-growing cream, belongs to the cosmetic product technical field.
Background technology
Skin is comprised of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe by three approach.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in the daily life, most hair-growing creams are aqueous solutions, and epidermal growth factor, collagen protein, ginkgetin, the important life active compound such as histidine all is water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity hair growth promoting composition utilization rate very little.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention provides a kind of liposome hair-growing cream, and it is carried to deep skin take liposome as carrying China with various nutritional labelings, fully absorbed by human body, can increase hair elasticity, pliability, also can make hair restoration.
For realizing described goal of the invention, a kind of liposome hair-growing cream, it comprises the composition of following ratio of weight and number:
Preferably, the composition that also comprises following ratio of weight and number:
Compared with prior art, liposome hair-growing cream provided by the invention, it is carried to deep skin take liposome as carrying China with various nutritional labelings, is fully absorbed by human body, can increase hair elasticity, pliability, also can make hair restoration.
Description of drawings
Fig. 1 is the sketch map of the skin absorption process of the skin care item that provide in the prior art;
Fig. 2 is the sketch map of the skin absorption process of liposome hair-growing cream provided by the invention.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
This embodiment provides a kind of increases hair elasticity, pliability, and can make the liposome hair-growing cream of hair restoration.Described liposome hair-growing cream comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SCGF) | 0.01-0.1 |
| Hyaluronic acid | 10.0-10,000.0 |
| Phospholipid | 0.003-3000.0 |
| Biotin | 0.001-100.0 |
| Ginkgetin | 0.001-100.0 |
| Fibroin | 0.001-10.0 |
| Collagen protein | 0.01-100.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome hair-growing cream that this embodiment provides is: 100mg phospholipid and 25mg cholesterol are dissolved in the 30ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 500mg hyaluronic acid, 5mg fibroin, 5mg collagen protein, 25mg biotin and 25mg ginkgetin are dissolved in the 40ml deionized water (perhaps aqueous phosphatic PH=6.8) and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome hair-growing cream of an epidermal growth factor, human stem cell growth, fibroin, collagen protein, biotin and ginkgetin.
Fig. 2 is the sketch map of the skin absorption process of liposome hair-growing cream provided by the invention.As shown in Figure 2 because to seal the liposome adventitia of nutritional labeling similar to human body cell outer membrane structure and composition, so gap and the direct transdermal of skin subsidiary pipeline opening that complete liposome can pass between horn cell, the horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in the double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome phospholipid and Stratum corneum lipids merge changes the horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure, by the lipid granule gap, liposomal encapsulated medicine or nutritional labeling are convenient to enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in the human body metabolism, keep one of necessary basic substance of human normal physiological function, have targeting as pharmaceutical carrier, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity, be applicable to biological vivo degradation, can protect the entrapped superficial growth factor and metallothionein, and can carry the nutritional labelings such as the superficial growth factor and fibroin and pass horny layer and enter corium and subcutaneous tissue.The nutritional labelings such as alleviation, the controlled release superficial growth factor in corium and subcutaneous tissue.Because liposome has targeting, can improve the superficial growth factor etc. in the bioavailability of skin.
The liposome hair-growing cream that this truth example provides is on probation through 100 Mies of 30 years old to 45 years old, and after 20 days, 90% people's hair elasticity strengthens, pliability is good, and obviously no longer alopecia.
Embodiment 2
This embodiment provides a kind of increases hair elasticity, pliability, and can make the liposome hair-growing cream of hair restoration.Described liposome hair-growing cream comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg/L |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth | 0.01-0.1 |
| Hyaluronic acid | 10.0-10,000.0 |
| Lipoid | 0.001-1000.0 |
| Phospholipid | 0.003-3000.0 |
| Fatty acid | 0.001-1000.0 |
| Biotin | 0.001-100.0 |
| Ginkgetin | 0.001-100.0 |
| Fibroin | 0.001-10.0 |
| Collagen protein | 0.01-100.0 |
| Vitamin E | 0.001-200.0 |
| Vitamin C | 0.001-200.0 |
| Vitamin K | 0.001-200.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome hair-growing cream that this embodiment provides is: 100mg phospholipid, 100mg lipoid, 100mg fatty acid, 25mg cholesterol, 25mg vitamin E, 25mg vitamin K are dissolved in the 40ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 500mg hyaluronic acid, 5mg fibroin, 5mg collagen protein, 20mg biotin, 20mg ginkgetin and 25mg vitamin C are dissolved in the 50ml deionized water (perhaps aqueous phosphatic PH=6.8) and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome hair-growing cream of the compositions such as an epidermal growth factor, human stem cell growth.Preferably, described phospholipid is lecithin.
Liposome hair-growing cream in the present embodiment is on probation through 100 Mies of 20 years old to 45 years old, and after 10 days, 90% people's hair elasticity strengthens, pliability is good, and has obviously grown new.
In addition, can liposome and solution separating be opened with the SephadexG50 chromatographic column if need.
Liposome hair-growing cream provided by the invention is the high-tech carrier for active principle in a kind of tip, consisted of by the phospholipid bimolecular, include the miniature vesicle of water purification, the nutritional labelings such as the quantitative epidermal growth factor of the internal energy encapsulation of vesicle, human stem cell, its average diameter is 100 nanometers, is 1/200～1/300 of human body cell diameter, can penetrate easily the human body skin top layer, with cell fusion, the performance effect.Therefore, liposome hair-growing cream provided by the invention is the natural nutriment of hair follicle development, both can be used for treating natural on-off cycles of hair growth and has grown the alopecia person who hinders, and also can be used as the hair healthy daily indispensable nursing product of being grown up, be used for delaying cell aging, prevent the generation of excessive alopecia, and it is new to grow.
The using method of liposome hair-growing cream provided by the invention:
1, after the hair washing this product evenly spread upon on scalp and the hair and stop after 5 minutes, clear water is cleaned and is got final product;
2 or temperature to bathe 10 minutes effects better; 3, consumption is too much unsuitable, smears all with skin and hair to be as the criterion.
The effect that below describes in conjunction with the embodiments component of the present invention, preparation method in detail and reach, but the embodiment instrument is for the explanation the present invention of demonstration ground.The description instrument is for explaining claims.But protection scope of the present invention is not limited to description.Any those skilled in the art of being familiar with are in the technical scope that the present invention discloses, and the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (2)
1. liposome hair-growing cream, it comprises the composition of following ratio of weight and number:
2. liposome hair-growing cream according to claim 1, it also comprises the composition of following ratio of weight and number:
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524247.4A CN102988196B (en) | 2012-12-10 | 2012-12-10 | Liposome hair growing preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524247.4A CN102988196B (en) | 2012-12-10 | 2012-12-10 | Liposome hair growing preparation |
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| CN102988196A true CN102988196A (en) | 2013-03-27 |
| CN102988196B CN102988196B (en) | 2014-12-10 |
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| CN201210524247.4A Expired - Fee Related CN102988196B (en) | 2012-12-10 | 2012-12-10 | Liposome hair growing preparation |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078138A (en) * | 1993-03-06 | 1993-11-10 | 青岛海洋大学 | Liquid for hair-growth |
| CN1310627A (en) * | 1998-07-28 | 2001-08-29 | 梅迪科股份有限公司 | Hair growth/maintenance compositions and methods involving the same |
| CN1899249A (en) * | 2005-07-21 | 2007-01-24 | 财团法人台湾动物科技研究所 | Composition for promoting hair growth |
| CN101054579A (en) * | 2007-03-29 | 2007-10-17 | 上海复旦新杨生物科技有限责任公司 | A siRNA capable of preventing and curing hair loss and accelerating hair growth, and preparation method and application thereof |
| CN101199837A (en) * | 2007-11-30 | 2008-06-18 | 何荫良 | Humanized cell factor hair agent and preparing method thereof |
| CN101313881A (en) * | 2007-05-29 | 2008-12-03 | 李燕强 | Shampoo composition redounding to hair generation |
| CN102772324A (en) * | 2012-07-06 | 2012-11-14 | 南通帝星化工有限公司 | Anti-hair loss shampoo |
-
2012
- 2012-12-10 CN CN201210524247.4A patent/CN102988196B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078138A (en) * | 1993-03-06 | 1993-11-10 | 青岛海洋大学 | Liquid for hair-growth |
| CN1310627A (en) * | 1998-07-28 | 2001-08-29 | 梅迪科股份有限公司 | Hair growth/maintenance compositions and methods involving the same |
| CN1899249A (en) * | 2005-07-21 | 2007-01-24 | 财团法人台湾动物科技研究所 | Composition for promoting hair growth |
| CN101054579A (en) * | 2007-03-29 | 2007-10-17 | 上海复旦新杨生物科技有限责任公司 | A siRNA capable of preventing and curing hair loss and accelerating hair growth, and preparation method and application thereof |
| CN101313881A (en) * | 2007-05-29 | 2008-12-03 | 李燕强 | Shampoo composition redounding to hair generation |
| CN101199837A (en) * | 2007-11-30 | 2008-06-18 | 何荫良 | Humanized cell factor hair agent and preparing method thereof |
| CN102772324A (en) * | 2012-07-06 | 2012-11-14 | 南通帝星化工有限公司 | Anti-hair loss shampoo |
Non-Patent Citations (1)
| Title |
|---|
| 裘炳毅: "《化妆品化学与工艺技术大全》", 30 June 1997, article "《生发或养发水》", pages: 1225-1229 * |
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