CN102988200B - Liposome face-nourishing skin care product - Google Patents
Liposome face-nourishing skin care product Download PDFInfo
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- CN102988200B CN102988200B CN201210524264.8A CN201210524264A CN102988200B CN 102988200 B CN102988200 B CN 102988200B CN 201210524264 A CN201210524264 A CN 201210524264A CN 102988200 B CN102988200 B CN 102988200B
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Abstract
The invention relates to a liposome face-nourishing skin care product, belonging to the technical field of cosmetics. The liposome face-nourishing skin care product comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 10.0-10,000.0 parts of hyaluronic acid, 0.003-3000.0 parts of phospholipid, 0.001-10.0 parts of metallothionein, 0.001-10.0 parts of collagen, 0.01-100.0 parts of male larva, and 0.001-200.0 parts of cholesterol. The skin care product provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The skin care product can deeply humidify horny cells and enhance hydration to improve the skin softness, and can provide sufficient nutrients to ensure skin health and increase skin resistance.
Description
Technical field
The present invention relates to a kind of liposome face nourishing skin care products, relate in particular to and a kind ofly enough solve that skin is intensely dark, flexibility decrease, aging problem and can pore convergence, smooth the liposome face nourishing skin care products of wrinkle, belong to cosmetic product technical field.
Background technology
Skin is made up of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance by three approach, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in daily life, most skin care milks are aqueous solutions, and the superficial growth factor, human stem cell growth (SCGF), protein, aminoacid, barbaloin, the important life active compound such as vitamin is all water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity skin care item utilization rate very little, the long-term water solublity skin care item of using, easily cause nutritional labeling waste and easily stop up pore.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention is to provide a kind of liposome face nourishing skin care products, it is taking liposome as carrying China, various nutritional labelings are carried to deep skin, fully absorbed by human body, these skin care item enough solve that skin is intensely dark, flexibility decrease, aging problem and can pore convergence, smooth wrinkle.
For realizing described goal of the invention, a kind of liposome face nourishing skin care products of the present invention, it comprises the composition of following ratio of weight and number:
Preferably, it also comprises the composition of following ratio of weight and number:
Compared with prior art, liposome face nourishing skin care products provided by the invention, it is taking liposome as carrying China, various nutritional labelings are carried to deep skin, can promote propagation and the growth of skin tissue cell, make newborn young cell substitute rapidly old and feeble dead cell, thus the mean age of reducing the cell that forms skin, to solve the dim light of skin, flexibility decrease and aging problem, and can make whitening skin, wrinkle reduce.
Brief description of the drawings
Fig. 1 is the schematic diagram of the skin absorption process of the skin care item that provide in prior art;
Fig. 2 is the schematic diagram of the skin absorption process of liposome face nourishing skin care products provided by the invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
This embodiment provides one can solve the dim light of skin, flexibility decrease and aging, and the liposome face nourishing skin care products that can make whitening skin, wrinkle reduce.Described liposome face nourishing skin care products comprises the composition of the weight part ratio described in following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SCGF) | 0.01-0.1 |
| Hyaluronic acid | 10.0-10,000.0 |
| Phospholipid | 10-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome face nourishing skin care products that this embodiment provides is: phosphatidase 11 00mg, cholesterol 25mg are dissolved in 30ml ethanol (or chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, reduction vaporization desolventizes (35 DEG C ± 1 DEG C of bath temperature) to remove, and pass into every now and then nitrogen, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor, 0.05mgSCGF (purchased from Peprotech company), 2000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein and 25mg arbutin is dissolved in 40ml deionized water (or aqueous phosphatic PH=6.8) and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, spy formula Ultrasound Instrument makes the abundant aquation 20-120 minute of lipid membrane under ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome face nourishing skin care products of an epithelical cell growth factor (EGF), human stem cell growth (SCGF), hyaluronic acid, metallothionein, collagen protein, arbutin and cholesterol.
Fig. 2 is the schematic diagram of the skin absorption process of liposome face nourishing skin care products provided by the invention.Similar to human body cell outer membrane structure and composition owing to sealing the liposome adventitia of nutritional labeling as shown in Figure 2, therefore complete liposome can gap and the direct transdermal of skin subsidiary pipeline opening through horn cell, horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome provides necessary fatty acid and lipid bilayer, liposome phospholipid and Stratum corneum lipids merge changes horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure of half, by lipid granule gap, liposomal encapsulated medicine or nutritional labeling are convenient to enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in human body metabolism, maintain one of necessary basic substance of human normal physiological function, there is targeting as pharmaceutical carrier, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity; be applicable to biological vivo degradation; can protect the entrapped superficial growth factor and metallothionein etc., and can carry the nutritional labelings such as the superficial growth factor and metallothionein and enter corium and subcutaneous tissue through horny layer.Alleviation, the controlled release superficial growth factor and metallothionein etc. in corium and subcutaneous tissue.Because liposome has targeting, can improve the bioavailability at skin such as the superficial growth factor and metallothionein.
The prepared liposome face nourishing skin care products of this embodiment is on probation through 100 Mies of 30 years old to 45 years old, and after 20 days, 95% people's skin light is on the face gorgeous, pale, and elasticity strengthens, wrinkle reduces.
Embodiment 2
This embodiment provides one enough to solve the dim light of skin, flexibility decrease and aging, can make whitening skin, wrinkle reduce, and can make skin keep moistening liposome face nourishing skin care products.Described liposome face nourishing skin care products comprises the composition of the weight part ratio described in following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Vascular endothelial cell growth factor (VEGF) | 0.05-8.0 |
| Hyaluronic acid | 10.0-10,000.0 |
| Human stem cell growth | 0.01-0.1 |
| Phospholipid | 10-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Elastin laminin | 0.001-10.0 |
| Fibrous protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Barbaloin | 0.001-100.0 |
| Aminoacid | 0.001-10.0 |
| Vitamin E | 0.001-1000.0 |
| Vitamin C | 0.001-1000.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome face nourishing skin care products that this embodiment provides is: phosphatidase 11 00mg, vitamin E2 5mg and cholesterol 25mg are dissolved in 40ml ethanol (or chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, reduction vaporization desolventizes (35 DEG C ± 1 DEG C of bath temperature) to remove, and pass into every now and then nitrogen, until volatilization completely, then at room temperature dry 24 hours, take 3.0mg epidermal growth factor, 0.05mgSCGF (purchased from Peprotech company), 1mg vascular endothelial cell growth factor (VEGF), 1000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin, 5mg fibrous protein, 20mg arbutin, 20mg barbaloin, 5mg aminoacid and 25mg vitamin C are dissolved in 50ml deionized water (or aqueous phosphatic PH=6.8) and on water-bath Rotary Evaporators and constantly under rotation jolting, shake up to obtain aqueous solution II, then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, spy formula Ultrasound Instrument makes the abundant aquation 20-120 minute of lipid membrane under ice-water bath condition, until become transparent to emulsion, obtain carrying epithelical cell growth factor (EGF), vascular endothelial cell growth factor (VEGF), VEGF, hyaluronic acid, stem cell factor, metallothionein, collagen protein, elastin fiber shape albumen, arbutin, barbaloin, aminoacid, the liposome face nourishing skin care products of vitamin E and vitamin C etc.
Liposome can protect the nutritional labelings such as entrapped epidermal growth factor, SCGF (purchased from Peprotech company), hyaluronic acid, metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, barbaloin, aminoacid, vitamin E and vitamin C to enter corium and subcutaneous tissue through horny layer, is fully absorbed and utilizes.
The liposome face nourishing skin care products that the present embodiment is produced is on probation through 100 Mies of 35 years old to 45 years old, and after 10 days, 95% people's skin light is on the face gorgeous moist, pale, and elasticity strengthens, wrinkle reduces.After 30 days, 98% people's wrinkle is almost eliminated, skin bright and cleanly moistens, mottle and freckle are obviously eliminated, and skin elasticity strengthens greatly, and will have a competition by the front obvious youth that seems.
In addition, can liposome and solution separating be opened with SephadexG50 chromatographic column if needed.
Liposome face nourishing skin care products provided by the invention is a kind of most advanced and sophisticated high-tech carrier for active principle, formed by phospholipid bimolecular, include the miniature vesicle of water purification, the nutritional labelings such as can encapsulation in vesicle quantitative epidermal growth factor, metallothionein, human stem cell, its average diameter is 100 nanometers, is 1/200～1/300 of human body cell diameter, can penetrate easily human body skin top layer, with cell fusion, performance effect.Therefore, liposome face nourishing skin care products provided by the invention, can promote cell regeneration, solve the dim light of skin, flexibility decrease and aging problem and there is good skin care effect, can go deep into humidifying horn cell and strengthen hydration to improve the flexibility of skin, thereby can repair the normal physiological function that has the cell of damage to safeguard skin; Can provide enough nutrient to ensure the health of skin, strengthen skin resistance; There is superpower moist moisture-keeping function: have efficient moisture-keeping functions, deep layer moisturizing, improves the dry water shortage status of skin.
Below the effect that describes component of the present invention, preparation method in conjunction with the embodiments in detail and reach, but embodiment illustrates the present invention for demonstrating.Description is only for explaining claims.But protection scope of the present invention is not limited to description.In the technical scope that any those skilled in the art of being familiar with disclose in the present invention, the variation that can expect easily or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (2)
1. a liposome face nourishing skin care products, prepare by the following method: phosphatidase 11 00mg, cholesterol 25mg are dissolved in 30ml ethanol, chloroform, methanol or dichloromethane, even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting, bath temperature is 35 DEG C ± 1 DEG C, and pass into every now and then nitrogen, solvent removed by evaporation at reduced pressure, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor (EGF), 0.05mg human stem cell growth (SCGF), 2000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein and 25mg arbutin is dissolved in 40ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, use spy formula Ultrasound Instrument under ice-water bath condition, to make the abundant aquation 20-120 minute of lipid membrane, until that emulsion becomes is transparent.
2. a liposome face nourishing skin care products, prepare by the following method: phosphatidase 11 00mg, vitamin E2 5mg and cholesterol 25mg are dissolved in 40ml ethanol, chloroform, methanol or dichloromethane, even the solution I of vibrating, then put into eggplant-shape bottle, on water-bath Rotary Evaporators, constantly rotate under jolting 35 DEG C ± 1 DEG C of bath temperature, and pass into every now and then nitrogen, solvent removed by evaporation at reduced pressure, until volatilization completely, then at room temperature dry 24 hours; Taking 3.0mg epidermal growth factor (EGF), 0.05mg human stem cell growth (SCGF), 1mg vascular endothelial cell growth factor (VEGF), 1000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin, 5mg fibrous protein, 20mg arbutin, 20mg barbaloin, 5mg aminoacid and 25mg vitamin C is dissolved in 50ml deionized water and on water-bath Rotary Evaporators constantly and shakes up to obtain aqueous solution II under rotation jolting; Then above-mentioned aqueous solution II is added in above-mentioned eggplant-shape bottle, on water-bath Rotary Evaporators, constantly under rotation jolting, obtain liposome emulsion, use spy formula Ultrasound Instrument under ice-water bath condition, to make the abundant aquation 20-120 minute of lipid membrane, until that emulsion becomes is transparent.
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| CN201210524264.8A CN102988200B (en) | 2012-12-10 | 2012-12-10 | Liposome face-nourishing skin care product |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210524264.8A CN102988200B (en) | 2012-12-10 | 2012-12-10 | Liposome face-nourishing skin care product |
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| CN102988200B true CN102988200B (en) | 2014-09-17 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103276002B (en) * | 2013-05-31 | 2015-01-07 | 吉林农业大学 | Oil body containing oil body protein and collagen fusion protein |
| CN103505403B (en) * | 2013-09-29 | 2015-08-19 | 广州市娇兰化妆品有限公司 | Epidermal growth factor composite liposome body and its preparation method and application |
| CN104606078A (en) * | 2015-02-06 | 2015-05-13 | 深圳唯美度生物科技有限公司 | Whitening cream applied to sensitive skin |
| CN105055187B (en) * | 2015-09-14 | 2018-02-09 | 广州赛莱拉干细胞科技股份有限公司 | A kind of face rejuvenation cosmetic formulation and preparation method thereof |
| WO2018144093A2 (en) * | 2016-11-03 | 2018-08-09 | Pinsky Mark A | Formulations for improved skin care |
| CN107510620A (en) * | 2017-09-26 | 2017-12-26 | 广西民族大学 | A kind of moisturizing whitening is dispelled the formula of Essence |
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