CN1234227A - Face-beauty composition containing biological repair factor and its application - Google Patents
Face-beauty composition containing biological repair factor and its application Download PDFInfo
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- CN1234227A CN1234227A CN 99113713 CN99113713A CN1234227A CN 1234227 A CN1234227 A CN 1234227A CN 99113713 CN99113713 CN 99113713 CN 99113713 A CN99113713 A CN 99113713A CN 1234227 A CN1234227 A CN 1234227A
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
The present invention relates to a face-beautifying composite and its application for beautifying skin. Said invented composite contains human basic fibroblast growth factor, human vascular endotheliocite growth factor, human epidermal cell growth factor, human nerve growth factor and melanic inhibitive factor. Said composite is simple in preparation, convenient for application,and can participate in metabolism of skin and its renovation from different layers and position points, can improve microcirculation of skin, renovate nerve ending and small muscle group so as to make skin more tender and rosy and possess rich elasticity.
Description
The present invention relates to a kind of the contain cosmetic composition of high-energy biological repair factor (Biomax-Factors) and the application in beautifying skin thereof.
The eighties mid-term, cell growth factor etc. are found that first subsequently, the U.S., France, Japan, Germany, Sweden waited the cell growth factor sequential use to medical cosmetology and cosmetic field.The high-energy biological repair factor comprises human alkaline fibroblast growth factor (hbFGF), human vascular endothelial growth factor (hVEGF), human epidermal growth factor (hEGF), growth factor of human nerve (hNGF) and Melanin inhibitive factor high-activity high-efficiency power cell growth factor such as (MIF).These factors can and be organized at gene, cell and act synergistically on skin on the level, regulate the metabolism of propagation, differentiation and the skin of Skin Cell efficiently, microcirculation improvement, make skin reach best Physiology and biochemistry state, they can prevent skin aging, suppress pigmentation, delay wrinkle formation, make ruddy, the glossy and elasticity of skin, simultaneously various types of skin injurys are all had repair function.But any individual cells factor is independently to finish the process of complexity like this, and for many years, people are devoted to seek and contain these composition of cellular factors to be applied to the beautifying skin field.
An object of the present invention is to provide a kind of can and organizing and act synergistically on skin on the level at gene, cell, regulate the metabolism of propagation, differentiation and the skin of Skin Cell efficiently, microcirculation improvement makes skin reach the cosmetic composition of best Physiology and biochemistry state.
Another object of the present invention is the application of described cosmetic composition on beautifying skin.
The objective of the invention is to implement: a kind of cosmetic composition by following design, come in parts by weight, comprise 15-55 part (weight) human alkaline fibroblast growth factor, 1-16 part (weight) human vascular endothelial growth factor, 5-35 part (weight) human epidermal growth factor, 0-25 part (weight) growth factor of human nerve, 5-35 part (weight) Melanin inhibitive factor.
Compositions of the present invention can be by conventional mixing, the preparation of technology such as vacuum, lyophilization.
Compositions of the present invention can be used for changing the reparation and the nursing of skin behind the skin, the reparation of damaging skin and nursing, promote aging skin to upgrade, strengthen wrinkle resistance, the removing of removing cutaneous pigmentation, mottle and acne is repaired nervous system, is promoted muscular tissue regeneration.The mechanism of action of described compositions is as follows:
The mechanism of action of Bi max-Factors
Shown in above-mentioned flow process, the high-energy biological repair factor has following mechanism of action:
(1) promote histiocyte regeneration, strengthen the cellular metabolism vigor, defying age:
Along with the increase at age, the subcutaneous fat of human body distributes and changes, the crosslinked phenomenon aggravation of the collagen fiber in the intercellular substance, elastic fiber and reticular fiber distortion, the function following formula, lipofuscin deposition, the skin urban district elasticity that becomes ossifys gradually, wrinkle appears, in addition sagging, and old and feeble sign appears.
The high-energy biological repair factor passes through many levels, different action sites acts synergistically on and originates from ectoderm and mesoblastic epidermis and hypodermal cell, promote cell division propagation by the combining of receptor-specific that shows with cell membrane, make it to become smooth, delicate.
Personnel selection epidermis free cell suspension culture, by measuring the speed of cell NAG enzymatic activity and cell mitogen, the division that can draw the biotic factor pair cell increases obvious facilitation.
Discover that the high-energy biological repair factor all has tangible proliferation function for epidermis cell, smooth muscle cell, osteocyte, epithelial cell, fibroblast.Promote the expression of mRNA, affected indirectly the expression of SOD, metallothionein simultaneously,, reach and promote cell division, tissue thickening, recover normal configuration young, healthy skin by the expression of cascade amplifying type model of action controlling gene.
(2) tissue of damaged skin, cytothesis, regeneration:
1. the damage of skin comprises: change operations such as skin damage, bulk tissue are damaged, burn, scald, medical science double eyelid plasty, augmentation rhinoplasty, breast enlargement, eyebrow tattooing art all cause to some extent skin damage, pachylosis, tuberosity usually appear in the sad repair process of collective, pigment is deepened or disappearance, the formation scar tissue.
2. damage maintenance mechanism: skin owing to removed horny layer, epithelium layer, makes outside the spine cell is exposed in impaired process, even some is to basal layer, and blood capillary also is exposed to the outside, usually causes secondary infection, causes pigmentation or the like.So damaged skin needs comprehensive repair such as epidermis, corium, blood vessel, muscle, nerves.
By acting on the effect of a plurality of sites, bring out epidermis, hypodermal cell, fibroblast, blood capillary, teleneuron and muscle etc. and produce a series of tissue repair sexual cell reaction, through complicated biochemical metabolism, attract some important cells to concentrate on damaged part, stimulate fibroblast propagation, blood capillary regeneration, skinization again on the synthetic and wound surface of the DNA of cell, the reparation and the regeneration of damage is finished in acceleration, makes the complete covering of epidermis cell, reduce or organize the cicatrix body formation,
(3) promote aging skin to upgrade, strengthen wrinkle resistance:
1. the generation of wrinkle of skin: find by physiological and biochemical research, 20 years old later body intracellular metabolic process of women just begun the aging process, in the 20-45 stage in year, nutrient and water reduces gradually, lacks in the histiocyte because metabolism weakens, and sebum reduces gradually, and the intradermal collagen fiber occur crosslinked, elastic fiber, reticular fiber degeneration, skin becomes and ossifys, and has lost elasticity thus, produces wrinkle.
2. crease-resistant mechanism: different cell receptor combination in high-energy biological repair factor and the skin cell tissue, synergism:
(1) promotes fibroblast secretion extracellular matrix, fibroblast secretion collagen protein, elastic fiber emiocytosis elastin laminin, matter between buffer cells.
(2) promote epidermis cell metabolism propagation, replace aged epidermis cell.
(3) growth of the subcutaneous blood capillary of promotion, microcirculation improvement.
(4) stimulate the emiocytosis collagenase and the plasminogen kinases at damaged position, regulate secretion, help the hydrolysis of distortion hardening collagen in the aging skin collagen protein and other proteoglycan, mucopolysaccharide.
(5) by to hyaluronic acid, soft burst of cytostromatic adjusting such as element of sulphuric acid, keep the content and the electrolytical metabolism of moisture in the Skin Cell, improve the exsiccosis of atrophic cells, recover skin moistened.Make skin recover normal elasticity and gloss by above-mentioned Physiological and Biochemical Metabolism process, the effect of reach minimizing, eliminating and prevent wrinkle to form.
(4) for the removing of cutaneous pigmentation, mottle and acne:
1. the reason of Xing Chenging: external environment condition and intrinsic factor, physical factor and chemical factor or the like, the jaundice blackout of skin mainly is wearing out owing to Skin Cell, the metabolism imbalance causes that melanin deposits in cell, the skin metabolism obstacle forms pathological changes, causes hair follicle pimple, furuncle joint, cyst, abscess, being dispersed in property blackhead and is dispersed in the irregular concavity cicatrix in shallow top layer, mottle, Pigmented formation.
2. the high-energy biological repair factor can suppress pigmentation and impel acne to remove:
(1) promotes the epidermis cell metabolism, upgrade aging skin, promote the gyro of aging skin cell, take away pigment, mottle.
(2) metabolism of promotion blood capillary, microcirculation improvement increases the supply of nutrient, the moisture transportation increases the blood flow in the skin histology, strengthens the eliminating of skin metabolism and harmful substance, make skin metabolism more unobstructed, prevent the formation of skin sore, mottle, make skin smooth, ruddy.
(3) growth, the growth of promotion teleneuron make skin sensitive more, lively, and the secretion function strengthens.
(4) promote that SOD forms in the body, remove free radical; And form metallothionein, and can resist the daylight middle-ultraviolet lamp to skin injury, stop lipid peroxidation and the deposition of deformation protein in cytoplasm, prevent the formation of cutaneous pigmentation and black speck.
(5) high-energy biological repair factor and nervous system reparation, anathreptic relation:
1. the high-energy biological repair factor acts on epidermis cell, and hair follicle tissue's cell promotes its regeneration.
2. promote to originate from the regeneration and the reparation of ectodermic nervous tissue cell.
3. promote the regeneration of muscular tissue cell.
4. has the excellent repairing preventive effect for cold injury.
(6) specificity of high-energy biological repair factor effect:
1. Synergistic phenomenon, the various kinds of cell factor exists simultaneously makes cell be in only vegetative state, and active force is stronger when the HA antioxidant share.
2. concentration and time and effect dependency are bigger.
The high-energy biological repair factor by with cell membrane on receptors bind produce its biological effect, as adding dimethyl sulfoxine, ammonia ketone material, may command rate of release on carrier.
4. the high-energy biological repair factor adds the corresponding effective percentage raising in the composite back of nutritive additive 15-20%
5. better with ultrasound wave importing method effect.
(7) show that after deliberation single use bFGF acts on people's skin, in the repair tissue cell, also increase melanic formation, make the whole pigment of into treatment sites deepen.
The high-energy biological repair factor can offset this effect substantially.Simultaneously, exclusive Melanin inhibitive factor in the present composition can make skin become more pale when finishing the skin histology maintenance again.
Cosmetic composition of the present invention is easy to prepare, uses simply, can participate in the metabolism and the restoration updating of skin from different levels, site, make the perfect covering of epidermis cell, makes skin better lubricious; Microcirculatory improvement makes skin more ruddy; The restoration updating of teleneuron make skin become more sensitivity is rich in life, little muscle group reparation makes skin be rich in innervation and elastic force more.
The invention will be further elaborated below by specific embodiment.
Embodiment 1
Take by weighing 1.2 * 10
6The hbFGF of iu (IU) (Intraoptics sells, California, USA), 1.28 * 10
6The hEGF of iu (IU) (Genetech sells, san francisco, usa), 2.8 * 10
6The hVEGF of iu (Chiron sells, California, USA), 2.0 * 10
6The hNGF of iu (military field pharmaceutical industries, Takeda Japan) and 7.2 * 10
5The MIF of iu (with medical bioengineering technology company of the Qin), these components are mixed and be dissolved in 1 liter of concentration be 20 mMs/liter PBS (pH6.5-7.5) in, filtration sterilization, obtain the product solution that concentration is the 8000IU/ milliliter, carry out packing with 2 ml vols, carry out lyophilizing by the conventional freeze drying process of biological product, gland gets final product.
Embodiment 2
With embodiment 1 described method, but adopt following formulation compositions of the present invention:
HbFGF (Mountain View, California, USA) 4.4 * 10
6IU
HEGF (Genetech sells, san francisco, usa) 8.0 * 10
6IU
HVEGF (Chiron sells, California, USA) 4.0 * 10
5IU
HNGF (military field pharmaceutical industries, Takeda Japan) 2.0 * 10
6IU
MIF (with medical bioengineering technology company of the Qin) 1.12 * 10
6IU
Embodiment 3
With embodiment 1 described method, but adopt following formulation compositions of the present invention:
HbFGF (Mountain View, California, USA) 2.8 * 10
6IU
HEGF (Genetech sells, san francisco, usa) 1.2 * 10
6IU
HVEGF (Chiron sells, California, USA) 1.6 * 10
5IU
MIF (with medical bioengineering technology company of the Qin) 2.4 * 10
6IU
Application Example 1
Type of impairment: burn, scald, ulcer, change the skin (face) behind the skin and change the improper skin lesion that causes of skin, the anaphylaxis behind the wasp.
Transfer fat to wash face with sterilization and reveal the cleaning face; The resurfacing Aloe is refined, and liquid is warm to be sprayed 4-8 minute.Use immersion of Aloe ossein and spin laced fabric then, cold spray 15 minutes.Did facial massage 4 minutes with zostera marina anti-anaphylaxis massage cream, the facial stop after 15 minutes, thoroughly wash clean.Repair the facial film pour mask with the algin Firm, get the film of washing one's face after 25-36 minute.Get 1 in the vacuum freeze-drying powder of embodiment 1 preparation, tear cillin bottle upper plastic lid and aluminium flake, inner rubber closure is unpluged.Add 1 of normal saline, rock mix homogeneously, get mixed liquor and evenly be applied to face, be massaged into till the absorption fully to fully dissolving.The available ultrasonic instrument of having ready conditions imports, or imports facial with importing and exporting instrument.
Application Example 2
Type of impairment: (comprising: cut the double eyelid wound, remove eye pouch etc.) hindered in the traumatic injury that skin is received, burn, scald, ulcer, operation.
Clear up wound surface with normal saline, sterilization.Get 1 of the lyophilized powder of embodiment 2 preparation, add 1 fully dissolving of normal saline, directly be applied to the wound surface place, embrocate 3-4 every day.Apply then and cover vaseline gentamycin antiinflammatory gauze and hospital gauze wrapping.Till using damage and healing fully.
Application Example 3
Reparation and nursing to defective skin and cicatrix body
Defect type: the cicatrix that skin nodules, cicatrix, acne, the acne that cause after foreign trader's healing cause, chickenpox, variola poison infect cicatrix, the cicatrix that orthomorphia causes and the cicatrix of washing eyebrow, eyeprint, tatooing and cause that causes.
See the affected part for details and do conventional medical disinfecting, the local infiltration anesthesia of reuse lignocaine.Use the skiving art.After finishing skiving, clear up wound surface, and cover the skiving position, stop blooding and throw off after 5-10 minute with the normal saline sterile gauze is deposited with normal saline.
Get 1 in the vacuum freeze-drying powder of embodiment 3 preparation, add 1 of normal saline, fully dissolving drops in facial into treatment sites.With vaseline gentamycin gauze and hospital gauze wrapping, remove gauze after 5 days, keep the wrapping of one deck vaseline gentamycin gauze and sterile gauze.After 5-7 days, kpetrolatum gauze was promptly tear-away, exposed lubricated, delicate skin, got well, elasticity.
Application Example 4
Aging skin crease-resistant, subtract wrinkle maintenance program:
Transferring fat to wash face with sterilization reveals the cleaning face, wrinkle place skin is sterilized with 75% medical alcohol.1 normal saline of 1 adding of product with embodiment 1 preparation dissolves, and this mixed liquor evenly is applied to visible subsidy, is massaged into fully to absorb.Available ultrasonic instrument with good conditionsi imports, or imports facial with importing and exporting instrument.
Application Example 5
The reparation of skin sore skin and nursing series
Skin characteristic: easily give birth to acne, acne, the sebum secretion metabolism is prosperous excessively; Follow the hair follicle inflammation, even the obstinate that shows effect repeatedly, local pigmentation caused.
Transfer fat to wash face with the sterilization desensitization and reveal cleaning skin.After sterilizing with disinfectant in the acne position, cleaning skin sore wound is cleaned out skin sore and pus (maybe can do ultraviolet light electrotherapy 3-6 minute) with the skin sore pin.Remove the part blackhead, clean up again.Get 1 of the product of embodiment 2 preparation, remove lid and inner rubber closure, the normal saline that adds 20 milliliters rocks mix homogeneously, with introducing apparatus or ultrasonoscope with mixed liquor importing face.After doing, the stock solution before the cosmetic composition lyophilizing of the present invention of repaste one deck.
Claims (7)
1. cosmetic composition, come in parts by weight, comprise 15-55 part (weight) human alkaline fibroblast growth factor, 1-16 part (weight) human vascular endothelial growth factor, 5-35 part (weight) human epidermal growth factor, 0-25 part (weight) growth factor of human nerve, 5-35 part (weight) Melanin inhibitive factor.
2. the application in the skin is repaired and nursed to cosmetic composition according to claim 1 after changing skin.
3. cosmetic composition according to claim 1 is in the reparation of damaging skin and the application in the nursing
4. cosmetic composition according to claim 1 strengthens the application in the skin wrinkle resisting promoting aging skin to upgrade.
5. the application of cosmetic composition according to claim 1 in the removing of removing cutaneous pigmentation, mottle and acne.
6. cosmetic composition according to claim 1 is being repaired nervous system, is being promoted the application in the muscular tissue regeneration.
7. according to the arbitrary described application of claim 2-7, it is characterized in that importing instrument by ultrasound wave imports the described cosmetic composition of claim 1 facial.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991137132A CN1138524C (en) | 1999-05-17 | 1999-05-17 | Face-beauty composition containing biological repair factor and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991137132A CN1138524C (en) | 1999-05-17 | 1999-05-17 | Face-beauty composition containing biological repair factor and its application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1234227A true CN1234227A (en) | 1999-11-10 |
| CN1138524C CN1138524C (en) | 2004-02-18 |
Family
ID=5276874
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB991137132A Expired - Lifetime CN1138524C (en) | 1999-05-17 | 1999-05-17 | Face-beauty composition containing biological repair factor and its application |
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| Country | Link |
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| CN (1) | CN1138524C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100372522C (en) * | 2005-12-02 | 2008-03-05 | 何秋莎 | Skin care product |
| CN102988200A (en) * | 2012-12-10 | 2013-03-27 | 北京莱米瑞克科技发展有限公司 | Liposome face-nourishing skin care product |
| CN102988194A (en) * | 2012-12-10 | 2013-03-27 | 北京莱米瑞克科技发展有限公司 | Liposome essence |
| CN104622709A (en) * | 2015-01-30 | 2015-05-20 | 姜振宇 | Human stem cell factor skin repairing solution and preparation method thereof |
| CN111228132A (en) * | 2020-03-02 | 2020-06-05 | 赵梓纲 | Skin composite preparation |
-
1999
- 1999-05-17 CN CNB991137132A patent/CN1138524C/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100372522C (en) * | 2005-12-02 | 2008-03-05 | 何秋莎 | Skin care product |
| CN102988200A (en) * | 2012-12-10 | 2013-03-27 | 北京莱米瑞克科技发展有限公司 | Liposome face-nourishing skin care product |
| CN102988194A (en) * | 2012-12-10 | 2013-03-27 | 北京莱米瑞克科技发展有限公司 | Liposome essence |
| CN102988200B (en) * | 2012-12-10 | 2014-09-17 | 北京莱米瑞克科技发展有限公司 | Liposome face-nourishing skin care product |
| CN102988194B (en) * | 2012-12-10 | 2014-09-17 | 北京莱米瑞克科技发展有限公司 | Liposome essence |
| CN104622709A (en) * | 2015-01-30 | 2015-05-20 | 姜振宇 | Human stem cell factor skin repairing solution and preparation method thereof |
| CN104622709B (en) * | 2015-01-30 | 2017-09-26 | 姜振宇 | Human stem cell factor skin repair liquid and preparation method thereof |
| CN111228132A (en) * | 2020-03-02 | 2020-06-05 | 赵梓纲 | Skin composite preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1138524C (en) | 2004-02-18 |
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