CN110478306A - Facial mask of the culture supernatant containing placenta mesenchyma stem cell and preparation method thereof - Google Patents
Facial mask of the culture supernatant containing placenta mesenchyma stem cell and preparation method thereof Download PDFInfo
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- CN110478306A CN110478306A CN201910836290.6A CN201910836290A CN110478306A CN 110478306 A CN110478306 A CN 110478306A CN 201910836290 A CN201910836290 A CN 201910836290A CN 110478306 A CN110478306 A CN 110478306A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a kind of facial mask and preparation method thereof of culture supernatant containing placenta mesenchyma stem cell, is related to daily cosmetics field.The facial mask includes following components: placenta mesenchyma stem cell culture supernatant, hazel extract, buckwheat seed extract, moisturizer, water lock agent, thickener, emulsifier, vitamin, collagen and chitosan.Facial mask of the invention has the effect of that deep layer nourishes epidermal cell, promotes cell repair and regeneration, promotes skin healing.
Description
Technical field
The present invention relates to daily cosmetics fields, more particularly to a kind of culture supernatant containing placenta mesenchyma stem cell
Facial mask and preparation method thereof.
Background technique
Skin is the important barrier together of human body.Outside skin of face is chronically exposed to, by exposing to the weather, epidermal cell holds
Easily be oxidized and damage, skin is made to become drying, it is possible to will cause burn, chafing and scar.Moreover, with year
The update of the increase in age, Skin Cell slows down, and causes skin aging and apoptotic cell to update and slows down, collagen in skin
It is lost, causes pigementation and leave freckle.In daily life, people protect skin of face often through application facial mask
It supports.
However, facial mask currently used in the market mostly by industrial chemicals for example glycerol, siliceous smooth dose etc. form, can only be short
Temporarily, the problem of outwardly alleviating skin water shortage, effect is not lasting, and can not gradually repair skin injury, dispeling scar.Cause
This, provides a kind of facial mask with long-time moisturizing, reparation damage effect, has broad application prospects on the market.
Summary of the invention
Based on this, it is necessary to repair the not sufficiently effective problem of skin injury for existing facial mask, provide a kind of containing between placenta
The facial mask of mesenchymal stem cells culture supernatant.
A kind of facial mask of the culture supernatant containing placenta mesenchyma stem cell, including following components: placenta mesenchyma stem cell
Culture supernatant, hazel extract, buckwheat seed extract, moisturizer, water lock agent, thickener, emulsifier, vitamin, collagen
Albumen and chitosan.
Above-mentioned facial mask, each component cooperate, and extract particularly by placenta mesenchyma stem cell culture supernatant, witch hazel
The compounding of liquid and buckwheat seed extract reaches deep layer and nourishes epidermal cell, promote cell repair and regeneration, promote skin healing
Purpose.
Wherein, in placenta mesenchyma stem cell culture supernatant be rich in various kinds of cell growth factor, as EGF, bFGF, KGF,
TGF-β, VEGF etc. are that placenta mesenchyma stem cell is secreted in normal growth course, these growth factors can have
The regulation body signal transduction of effect, activation body have cell, and then achieve the purpose that repair body injury, aging, lesion.Table
Skin growth factor (EGF) is a kind of polypeptide being made of 53 amino acid, is declined by stimulation epidermal cell proliferation to update replacement
Old and dead cell, can additionally promote subcutaneous collagen fiber deposition to reach makes epidermal cell become full, restores young
State.Basic fibroblast growth factor (bFGF) has intense stimulus effect to various kinds of cell proliferation, can improve skin
The microenvironment of cell growth promotes skin fibroblasts growth, repairs damaged cell in skin；Promote collagenous fibres and elasticity
Fiber synthesis, makes skin have elasticity；Melanin and coloured corpuscle content in skin are reduced, Skin pigmentation is mitigated.Cutin
Growth factor-21 (KGF-1) specifically stimulates the proliferation of epithelial cell, under epidermis by combining with receptor (KGFR)
Blood vessel and fibroblast do not act on, thus can specifically repair damage skin.Meanwhile KGF-1 can reinforce skin follicle and
The proliferation and differentiation of the precursor of sebaceous glands.To the operation of laser ablation red capillary, the operation of laser nti-freckle, injection water laser accunputure etc. draws
Playing tissue damage has significant protection and promotes repair, reduces nursing burden, avoids wound infection.Transforming growth factor
(TGF-β) can effectively facilitate skin wound healing, promote subcutaneous collagen fiber deposition.Vascular endothelial growth factor
(VEGF) vascular endothelial cell growth can be effectively facilitated in vivo and in vitro, and local use can stimulate subcutaneous capillary
Regeneration increases skin histology supply of blood flow, provides enough nutrition for skin tissue regeneration.In addition, placenta mesenchyma stem cell point
Include a variety of tiny RNAs in the excretion body secreted, has and promote skin cell proliferation, promote subcutaneous collagen deposition, anti-fibrosis etc. solely
Special biological activity.
Contain a variety of tannin matter in hamamelis extract, adjustable sebum secretion restrains oil-control；Lymph blood can be promoted to follow
Ring overcomes morning eye bladder and black eye；Have the effect of calmness, pacify, has improvement to cracking, sunburn, acne；With guarantor
Wet and Milk Protein can effectively help the power of regeneration at skin night, can delay anaphylaxis skin.
Buckwheat seed extract has good antioxidant effect, all has very to DPPH free radical and ABTS free radical
Good elimination effect；The degradation of elastin laminin can be slowed down, maintain skin elasticity；It can inhibit the release of histamine, there is antiallergy
Effect.
The placenta mesenchyma stem cell culture supernatant is prepared by the following method in one of the embodiments,
Arrive: with serum free medium culture placenta mesenchyma stem cell, cultivation temperature is 37 ± 1 DEG C, and incubation time is 48~72h, from
The heart, centrifugal rotational speed are 12000~13000rpm, and centrifugation time is 10~20min, and supernatant is collected after centrifugation to get between placenta
Mesenchymal cells culture supernatant.
In one of the embodiments, include the component of following weight percent:
The solvent is deionized water in one of the embodiments,.
The moisturizer is selected from one of the embodiments: one of glycerine, 1,3-BDO and hyaluronic acid
Or it is a variety of；The water lock agent is ceramide.
The thickener is selected from one of the embodiments: hydroxyethyl cellulose, carboxymethyl cellulose, sodium alginate
With one of polyethylene glycol or a variety of.
The vitamin is mixed selected from one or both of vitamin B3 and vitamin B5 in one of the embodiments,
Object.
In one of the embodiments, include the component of following weight percent:
One aspect of the present invention also provides a kind of preparation method of above-mentioned facial mask, comprising the following steps:
1) taking polyethylene glycol, ceramide, glycerine or 1,3-BDO Hybrid Heating, obtain A liquid；
2) vitamin B3 is mixed with water, is heated, chitosan and hydroxyethyl cellulose or sodium alginate is added, obtains B liquid；
3) A liquid is mixed, homogeneous with B liquid, cools down, other raw materials is added, mixed, homogeneous is to get facial mask.
Active material (such as placenta mesenchyma stem cell culture supernatant, gold is added in preparation method of the invention after cooling
Thread plum extracting solution, buckwheat seed extract etc.), it is sufficiently reserved the bioactive ingredients of component.
In one of the embodiments, in the step 2), heating temperature is 55~65 DEG C；In the step 3), cooling
Temperature is 40 DEG C hereinafter, the time of homogeneous is 2~4min every time afterwards.
Compared with prior art, the invention has the following advantages:
Facial mask of the invention, each component cooperates, particularly by placenta mesenchyma stem cell culture supernatant, witch hazel
The compounding of extracting solution and buckwheat seed extract reaches deep layer and nourishes epidermal cell, promote cell repair and regeneration, skin is promoted to be cured
The purpose of conjunction.Preparation method of the invention is sufficiently reserved the activity of effective component according to the property of raw material components.
Specific embodiment
To facilitate the understanding of the present invention, below in conjunction with preferred embodiment to invention is more fully described.But
It is that the invention can be realized in many different forms, however it is not limited to embodiment described herein.On the contrary, providing this
The purpose of a little embodiments is to make the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
Following embodiment is raw materials used, is commercially available if not otherwise indicated.
Wherein: hamamelis extract, source: commercially available；Buckwheat seed extract, source: commercially available.
Embodiment 1
A kind of facial mask is comprised the following components in parts by weight in terms of 100 parts by weight: placenta mesenchyma stem cell culture supernatant
10 parts of liquid, 4 parts of glycerine, 0.2 part of polyethylene glycol .5 parts of Cer EOS, 1 part of vitamin B3,0.8 part of chitosan, hyalomitome
3 parts of acid, 0.2 part of hydroxyethyl cellulose/sodium alginate, 1.2 parts of vitamin B5,1.4 parts of collagen, hamamelis extract 2.5
Part, 1.0 parts of buckwheat seed extract, surplus is deionized water.
Above-mentioned facial mask is prepared by the following method to obtain:
1) polyethylene glycol and ceramide are added in glycerine, heating stirring is uniform, obtains A liquid
2) vitamin B3 is added in deionized water, is heated to 60 DEG C of stirring and dissolvings, chitosan and hydroxyl are added while stirring
Ethyl cellulose obtains B liquid；
3) A liquid is added into B liquid, is uniformly mixed, homogeneous 3min is cooled to 40 DEG C or less and other raw materials, homogeneous is added
3min is to get facial mask liquid.
4) face paper is soaked in the facial mask liquid of 25mL step 3) to get to containing culture containing placenta mesenchyma stem cell
The facial mask of supernatant.
Comparative example 1
A kind of facial mask is comprised the following components in parts by weight in terms of 100 parts by weight: 4 parts of glycerine, 0.2 part of polyethylene glycol,
.5 parts of Cer EOS, 1 part of vitamin B3,0.8 part of chitosan, 3 parts of hyaluronic acid, hydroxyethyl cellulose/sodium alginate 0.2
Part, 1.2 parts of vitamin B5,1.4 parts of collagen, 2.5 parts of hamamelis extract, 1.0 parts of buckwheat seed extract, surplus is to go
Ionized water.
The preparation method of the facial mask is same as Example 1.
Comparative example 2
A kind of facial mask is comprised the following components in parts by weight in terms of 100 parts by weight: placenta mesenchyma stem cell culture supernatant
10 parts of liquid, 4 parts of glycerine, 0.2 part of polyethylene glycol .5 parts of Cer EOS, 1 part of vitamin B3,0.8 part of chitosan, hyalomitome
3 parts of acid, 0.2 part of hydroxyethyl cellulose/sodium alginate, 1.2 parts of vitamin B5,1.4 parts of collagen, buckwheat seed extract 1.0
Part, surplus is deionized water.
The preparation method of the facial mask is same as Example 1.
Comparative example 3
A kind of facial mask is comprised the following components in parts by weight in terms of 100 parts by weight: placenta mesenchyma stem cell culture supernatant
10 parts of liquid, 4 parts of glycerine, 0.2 part of polyethylene glycol .5 parts of Cer EOS, 1 part of vitamin B3,0.8 part of chitosan, hyalomitome
3 parts of acid, 0.2 part of hydroxyethyl cellulose/sodium alginate, 1.2 parts of vitamin B5,1.4 parts of collagen, hamamelis extract 2.5
Part, surplus is deionized water.
The preparation method of the facial mask is same as Example 1.
Comparative example 4
A kind of facial mask is comprised the following components in parts by weight in terms of 100 parts by weight: umbilical cord mesenchymal stem cells culture supernatant
10 parts of liquid, 4 parts of glycerine, 0.2 part of polyethylene glycol .5 parts of Cer EOS, 1 part of vitamin B3,0.8 part of chitosan, hyalomitome
3 parts of acid, 0.2 part of hydroxyethyl cellulose/sodium alginate, 1.2 parts of vitamin B5,1.4 parts of collagen, hamamelis extract 2.5
Part, 1.0 parts of buckwheat seed extract, surplus is deionized water.
The preparation method of the facial mask is same as Example 1.
Experimental example 1
Random screening related personnel tries out mask product of the invention, after subject's facial cleansing, uses embodiment and right
The facial mask of ratio uses 2 times weekly, is used continuously 4 weeks, uses CBS-807 skin point 0 day, 7 days, 14 days, 21 days, 28 days
Analysis system detects skin of abdomen pore size, skin elasticity, the colour of skin, skin shine, skin depressions degree, wrinkle size etc..4
Zhou Hou, using effect are as shown in table 1:
Table 1. improves situation using rear skin
Wherein, the fewer expression pore of quantity of "+" is smaller in " skin pore size ", the quantity of "+" in " skin elasticity "
More multilist shows that elasticity is better, and the quantity of "+" more multilist shows that the colour of skin is better in " colour of skin ", and the quantity of "+" is got in " skin shine "
Multilist shows that gloss is better.As seen from Table 1, subject's skin after using facial mask of the present invention 1 week makes moderate progress, and is used continuously 4 weeks
Skin is obviously improved afterwards.
Experimental example 2
Female of 240 ages after progress water laser accunputure injection treatment in 20-45 years old or laser nti-freckle iatrotechnics is chosen in experiment
Property tested, be in 25 DEG C of experimentation in room temperature, taking several nonwoven cloth areas is 5 × 5cm, sticks facial mask liquid of the present invention
Respectively at right side face cutaneous lesion and right hand back.Facial mask described in embodiment and not is sticked with skinanalysis apparatus test
With the skin of face recovery situation before and after facial mask, the results are shown in Table 2:
2. damaged skin using effect of table
| Group | Number of cases | It cures | Alleviate |
| Embodiment 1 | 40 | 29 | 11 |
| Blank group | 40 | 11 | 29 |
| Comparative example 1 | 40 | 16 | 24 |
| Comparative example 2 | 40 | 20 | 20 |
| Comparative example 3 | 40 | 21 | 19 |
| Comparative example 4 | 40 | 25 | 15 |
As seen from Table 2, after using the facial mask of embodiment 1, the skin that most of user is burnt restores significant, skin
Red and swollen situation is also substantially reduced, it is seen that the present invention has preferable i.e. promotion skin regeneration and repair.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of facial mask of culture supernatant containing placenta mesenchyma stem cell, which is characterized in that including following components: being filled between placenta
Matter stem cell culture supernatant, hazel extract, buckwheat seed extract, moisturizer, water lock agent, thickener, emulsifier, dimension life
Element, collagen and chitosan.
2. facial mask according to claim 1, which is characterized in that the placenta mesenchyma stem cell culture supernatant by with
Lower section method is prepared: with serum free medium culture placenta mesenchyma stem cell, cultivation temperature is 37 ± 1 DEG C, incubation time
For 48~72h, centrifugation, centrifugal rotational speed is 12000~13000rpm, and centrifugation time is 10~20min, and supernatant is collected after centrifugation
Liquid is to get placenta mesenchyma cells and supernatant.
3. facial mask according to claim 1, which is characterized in that the component including following weight percent:
4. facial mask according to claim 3, which is characterized in that the solvent is deionized water.
5. facial mask according to claim 1, which is characterized in that the moisturizer is selected from: glycerine, 1,3-BDO and thoroughly
One of bright matter acid is a variety of；The water lock agent is ceramide.
6. facial mask according to claim 1, which is characterized in that the thickener is selected from: hydroxyethyl cellulose, carboxymethyl are fine
One of dimension element, sodium alginate and polyethylene glycol are a variety of.
7. facial mask according to claim 1, which is characterized in that the vitamin is in vitamin B3 and vitamin B5
One or two kinds of mixtures.
8. facial mask according to claim 1, which is characterized in that the component including following weight percent:
9. a kind of preparation method of facial mask according to any one of claims 8, comprising the following steps:
1) taking polyethylene glycol, ceramide, glycerine or 1,3-BDO Hybrid Heating, obtain A liquid；
2) vitamin B3 is mixed with water, is heated, chitosan and hydroxyethyl cellulose or sodium alginate is added, obtains B liquid；
3) A liquid is mixed, homogeneous with B liquid, cools down, other raw materials is added, mixed, homogeneous is to get facial mask.
10. preparation method according to claim 9, which is characterized in that in the step 2), heating temperature is 55~65
℃；In the step 3), temperature is 40 DEG C hereinafter, the time of homogeneous is 2~4min every time after cooling.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910836290.6A CN110478306A (en) | 2019-09-05 | 2019-09-05 | Facial mask of the culture supernatant containing placenta mesenchyma stem cell and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910836290.6A CN110478306A (en) | 2019-09-05 | 2019-09-05 | Facial mask of the culture supernatant containing placenta mesenchyma stem cell and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110934815A (en) * | 2019-12-24 | 2020-03-31 | 盛世荣恩生物科技有限公司 | Anti-saccharification mask containing mesenchymal stem cell culture supernatant and preparation method thereof |
| CN112190532A (en) * | 2020-10-10 | 2021-01-08 | 广州瑞铂茵健康科技有限公司 | Placenta freeze-dried powder smearing mask and preparation method thereof |
| CN113307851A (en) * | 2021-06-11 | 2021-08-27 | 北京戴域生物技术有限公司 | Application of active peptide and mesenchymal stem cell exosome for improving skin physiological characteristics in medicines or cosmetics |
| CN113616585A (en) * | 2021-05-17 | 2021-11-09 | 云南贺尔思细胞生物技术有限公司 | Whitening liquid containing placenta mesenchymal stem cells and preparation method thereof |
-
2019
- 2019-09-05 CN CN201910836290.6A patent/CN110478306A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110934815A (en) * | 2019-12-24 | 2020-03-31 | 盛世荣恩生物科技有限公司 | Anti-saccharification mask containing mesenchymal stem cell culture supernatant and preparation method thereof |
| CN112190532A (en) * | 2020-10-10 | 2021-01-08 | 广州瑞铂茵健康科技有限公司 | Placenta freeze-dried powder smearing mask and preparation method thereof |
| CN113616585A (en) * | 2021-05-17 | 2021-11-09 | 云南贺尔思细胞生物技术有限公司 | Whitening liquid containing placenta mesenchymal stem cells and preparation method thereof |
| CN113307851A (en) * | 2021-06-11 | 2021-08-27 | 北京戴域生物技术有限公司 | Application of active peptide and mesenchymal stem cell exosome for improving skin physiological characteristics in medicines or cosmetics |
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