CN102988194A - Liposome essence - Google Patents
Liposome essence Download PDFInfo
- Publication number
- CN102988194A CN102988194A CN2012105242135A CN201210524213A CN102988194A CN 102988194 A CN102988194 A CN 102988194A CN 2012105242135 A CN2012105242135 A CN 2012105242135A CN 201210524213 A CN201210524213 A CN 201210524213A CN 102988194 A CN102988194 A CN 102988194A
- Authority
- CN
- China
- Prior art keywords
- liposome
- skin
- parts
- essence
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to a liposome essence, belonging to the technical field of cosmetics. The liposome essence comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 0.003-3000.0 parts of phospholipid, 0.001-10.0 parts of metallothionein, 0.001-10.0 parts of collagen, 0.01-100.0 parts of arbutin, and 0.001-200.0 parts of cholesterol. The liposome essence provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The liposome essence can deeply humidify horny cells and enhance hydration to improve the skin softness, and can provide sufficient nutrients to ensure skin health and increase skin resistance and elasticity.
Description
Technical field
The present invention relates to a kind of liposome essence, relate in particular to and a kind ofly can solve that skin is intensely dark, flexibility decrease, aging problem and can the pore convergence, smooth the liposome essence of wrinkle, belong to the cosmetic product technical field.
Background technology
Skin is comprised of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe by three approach.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in the daily life, most skin care milks are aqueous solutions, the superficial growth factor, protein, aminoacid, nucleic acid, nucleotide, the important life active compound such as vitamin all is water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity skin care item utilization rate very little, for a long time use the water solublity skin care item, cause easily the nutritional labeling waste and stop up easily pore.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention provides a kind of liposome essence, it is take liposome as carrying China, various nutritional labelings are carried to deep skin, fully absorbed by human body, can solve that skin is intensely dark, flexibility decrease, aging problem and can make the pore convergence, smooth wrinkle.
For realizing described goal of the invention, the invention provides the liposome essence, comprising the composition of following ratio of weight and number:
Preferably, the composition that comprises following ratio of weight and number:
Preferably, the composition that also comprises following ratio of weight and number:
Compared with prior art, liposome essence provided by the invention, it is take liposome as carrying China, various nutritional labelings are carried to deep skin, can promote propagation and the growth of skin tissue cell, make the cell of newborn youth substitute rapidly old and feeble dead cell, thereby solve the dim light of skin, flexibility decrease and aging problem, and whitening skin, wrinkle are reduced.
Description of drawings
Fig. 1 is the sketch map of the skin absorption process of the skin care item that provide in the prior art;
Fig. 2 is the sketch map of the skin absorption process of liposome essence provided by the invention.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
This embodiment provides a kind of can solve the dim light of skin, flexibility decrease and aging, and the liposome spermin that whitening skin, wrinkle are reduced.Described liposome spermin comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SC6F) | 0.01-0.1 |
| Phospholipid | 0.003-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome essence that this embodiment provides is: phosphatidase 11 00mg, cholesterol 25mg are dissolved in the 30ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 5mg metallothionein, 5mg collagen protein and 25mg arbutin be dissolved in the 50ml deionized water (perhaps for aqueous phosphatic, PH=6.8) in and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome essence of an epidermal growth factor, human stem cell growth, metallothionein, collagen protein and arbutin.
Fig. 2 is the sketch map of the skin absorption process of liposome essence provided by the invention.As shown in Figure 2 because to seal the liposome adventitia of nutritional labeling similar to human body cell outer membrane structure and composition, so gap and the direct transdermal of skin subsidiary pipeline opening that complete liposome can pass between horn cell, the horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in the double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome phospholipid and Stratum corneum lipids merge changes the horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure, by the lipid granule gap, liposomal encapsulated medicine or nutritional labeling just enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in the human body metabolism, keep one of necessary basic substance of human normal physiological function, have targeting as pharmaceutical carrier, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity; be applicable to biological vivo degradation; can protect the entrapped superficial growth factor and human stem cell growth etc., and can carry the nutritional labelings such as the superficial growth factor and human stem cell growth and pass horny layer and enter corium and subcutaneous tissue.The compositions such as alleviation, the controlled release superficial growth factor and metallothionein in corium and subcutaneous tissue.Because liposome has targeting, can improve the compositions such as the superficial growth factor and human stem cell growth in the bioavailability of skin.
The liposome essence of sealing epidermal growth factor, human stem cell growth, metallothionein, collagen protein and arbutin is on probation through 100 Mies of 30 years old to 45 years old, after 20 days, 95% people's skin light on the face is gorgeous, pale, and elasticity strengthens, wrinkle reduces.
Embodiment 2
This embodiment provides a kind of dim light of skin, flexibility decrease and aging problem of enough solving, and whitening skin, wrinkle are reduced, and can make skin keep moistening liposome spermin.Described liposome spermin comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg/L |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth | 0.01-0.1 |
| Lipoid | 0.001-1000.0 |
| Phospholipid | 0.003-3000.0 |
| Fatty acid | 0.001-1000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Elastin laminin | 0.001-10.0 |
| Fibrous protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Vitamin E | 0.001-1000.0 |
| Vitamin C | 0.001-1000.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome essence that this embodiment provides is: phosphatidase 11 00mg, lipoid 100mg, fatty acid 200mg, cholesterol 25mg and vitamin E2 5mg are dissolved in the 50ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin 5mg, 5mg fibrous protein, 20mg arbutin and 25mg vitamin C are dissolved in the 70ml deionized water and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome essence of the nutritional labelings such as an epidermal growth factor, human stem cell growth, metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, vitamin E and vitamin C.Preferably, described phospholipid is lecithin.
Liposome essence in the present embodiment is on probation through 100 Mies of 30 years old to 45 years old, after 15 days,, skin light on the face is gorgeous moist, pale, and elasticity strengthens, wrinkle reduces.
Embodiment 3
This embodiment provides a kind of dim light of skin, flexibility decrease and aging problem of enough solving, and whitening skin, wrinkle are reduced and the good liposome spermin of moistening effect.Described liposome spermin comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Vascular endothelial cell growth factor (VEGF) | 0.05-8.0 |
| Hyaluronic acid | 10.0-10,000.0 |
| Stem cell factor | 0.01-0.1 |
| Lipoid | 0.001-1000.0 |
| Phospholipid | 0.003-3000.0 |
| Fatty acid | 0.001-1000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Elastin laminin | 0.001-10.0 |
| Fibrous protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Barbaloin | 0.001-100.0 |
| Aminoacid | 0.001-10.0 |
| Vitamin E | 0.001-1000.0 |
| Vitamin C | 0.001-1000.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome essence that this embodiment provides is: 100mg phospholipid, 100mg lipoid, 100mg fatty acid, 25mg vitamin E and 25mg cholesterol are dissolved in the 50m1 ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 1mg vascular endothelial cell growth factor (VEGF) 1000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein, 5mg elastin laminin, 5mg fibrous protein, 20mg arbutin, 20mg barbaloin, 5mg aminoacid and 25mg vitamin C are dissolved in the 70ml deionized water and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-30 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome essence of an epidermal growth factor, human stem cell growth, metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, vitamin E and vitamin C etc.
Liposome can be protected the nutritional labelings such as entrapped epidermal growth factor, SCGF (available from Peprotech company), metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, barbaloin, aminoacid, vitamin E and vitamin C to pass horny layer and enter corium and subcutaneous tissue, is fully absorbed and utilizes.
The liposome essence that present embodiment is produced is on probation through 100 Mies of 35 years old to 45 years old, and after 10 days, skin light on the face is gorgeous moist, pale, and elasticity strengthens, wrinkle reduces.After 30 days, wrinkle is almost eliminated, skin bright and cleanly moistens, mottle and freckle are obviously eliminated, and skin elasticity strengthens greatly, and will have a competition with the front obvious youth that seems.
In addition, can liposome and solution separating be opened with the SephadexG50 chromatographic column if need.
Liposome essence provided by the invention is made of the phospholipid bimolecular, include the miniature vesicle of water purification, the nutritional labelings such as the quantitative epidermal growth factor of the internal energy encapsulation of vesicle, metallothionein, human stem cell, its average diameter is 100 nanometers, it is 1/200～1/300 of human body cell diameter, can penetrate easily the human body skin top layer, with cell fusion, the performance effect.Therefore, liposome essence provided by the invention, can promote cell regeneration, solve the dim light of skin, flexibility decrease and aging problem, has good skin care effect, can go deep into the humidifying horn cell and strengthen hydration improving the flexibility of skin, thereby can repair the normal physiological function that the cell that damage is arranged is safeguarded skin; Can provide enough nutrient to guarantee the health of skin, strengthen skin resistance; Have superpower moist moisture-keeping functions, the deep layer moisturizing improves the dry water shortage status of skin.
The effect that below describes in conjunction with the embodiments component of the present invention, preparation method in detail and reach, but embodiment only is for the explanation the present invention of demonstration ground.Description only is for explaining claims.But protection scope of the present invention is not limited to description.Any those skilled in the art of being familiar with are in the technical scope that the present invention discloses, and the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (3)
1. liposome essence, it comprises the composition of following ratio of weight and number:
2. liposome essence according to claim 1, it also comprises the composition of following ratio of weight and number:
。
3. liposome essence according to claim 2, it also comprises the composition of following ratio of weight and number:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524213.5A CN102988194B (en) | 2012-12-10 | 2012-12-10 | Liposome essence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524213.5A CN102988194B (en) | 2012-12-10 | 2012-12-10 | Liposome essence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102988194A true CN102988194A (en) | 2013-03-27 |
| CN102988194B CN102988194B (en) | 2014-09-17 |
Family
ID=47917629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210524213.5A Expired - Fee Related CN102988194B (en) | 2012-12-10 | 2012-12-10 | Liposome essence |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102988194B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546639A (en) * | 2014-12-12 | 2015-04-29 | 黄宗堂 | Stem cell essence and preparation method thereof |
| CN106491486A (en) * | 2016-10-26 | 2017-03-15 | 武汉汉密顿生物科技股份有限公司 | A kind of liposome turbid liquor containing the derivative liquid of cord blood stem cell and preparation method thereof and the application in cosmetics |
| CN106821789A (en) * | 2017-03-30 | 2017-06-13 | 武汉润禾生物医药有限公司 | A kind of preparation method of B B-complex nourishing cream and its liposomal thing |
| CN110916038A (en) * | 2019-11-25 | 2020-03-27 | 利和(深圳)生物科技有限公司 | Preparation method of beverage for conditioning blood health |
| CN113576937A (en) * | 2021-08-06 | 2021-11-02 | 广州药妆日用化工有限公司 | Preparation method of arbutin solid nano-liposome |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63275506A (en) * | 1987-05-07 | 1988-11-14 | Pola Chem Ind Inc | Skin cosmetic |
| CN1234227A (en) * | 1999-05-17 | 1999-11-10 | 姜宁 | Face-beauty composition containing biological repair factor and its application |
| JP2009227632A (en) * | 2008-03-25 | 2009-10-08 | Ezaki Glico Co Ltd | External preparation for skin containing enzymatically synthesized glycogen |
| CN101816620A (en) * | 2010-03-12 | 2010-09-01 | 广州舒泰生物技术有限公司 | Whitening cosmetic product, preparation method and application thereof |
| US20110177140A1 (en) * | 2007-08-31 | 2011-07-21 | Rainer Voegeli | 4-amidino benzylamines for cosmetic and/or dermatological use |
| CN102247300A (en) * | 2010-12-24 | 2011-11-23 | 天津天狮生物发展有限公司 | Human epidermal growth factor nanoliposome and its preparation method |
| CN102512370A (en) * | 2011-12-28 | 2012-06-27 | 广州赛莱拉生物科技有限公司 | HSCGF liposome as well as preparation and application thereof |
-
2012
- 2012-12-10 CN CN201210524213.5A patent/CN102988194B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63275506A (en) * | 1987-05-07 | 1988-11-14 | Pola Chem Ind Inc | Skin cosmetic |
| CN1234227A (en) * | 1999-05-17 | 1999-11-10 | 姜宁 | Face-beauty composition containing biological repair factor and its application |
| US20110177140A1 (en) * | 2007-08-31 | 2011-07-21 | Rainer Voegeli | 4-amidino benzylamines for cosmetic and/or dermatological use |
| JP2009227632A (en) * | 2008-03-25 | 2009-10-08 | Ezaki Glico Co Ltd | External preparation for skin containing enzymatically synthesized glycogen |
| CN101816620A (en) * | 2010-03-12 | 2010-09-01 | 广州舒泰生物技术有限公司 | Whitening cosmetic product, preparation method and application thereof |
| CN102247300A (en) * | 2010-12-24 | 2011-11-23 | 天津天狮生物发展有限公司 | Human epidermal growth factor nanoliposome and its preparation method |
| CN102512370A (en) * | 2011-12-28 | 2012-06-27 | 广州赛莱拉生物科技有限公司 | HSCGF liposome as well as preparation and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 汤克勇: "《胶原物理与化学》", 31 January 2012, 科学出版社 * |
| 章苏宁: "《化妆品工艺学》", 30 September 2007, 中国轻工业出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546639A (en) * | 2014-12-12 | 2015-04-29 | 黄宗堂 | Stem cell essence and preparation method thereof |
| CN104546639B (en) * | 2014-12-12 | 2017-11-10 | 黄宗堂 | A kind of stem cell essence and preparation method thereof |
| CN106491486A (en) * | 2016-10-26 | 2017-03-15 | 武汉汉密顿生物科技股份有限公司 | A kind of liposome turbid liquor containing the derivative liquid of cord blood stem cell and preparation method thereof and the application in cosmetics |
| CN106821789A (en) * | 2017-03-30 | 2017-06-13 | 武汉润禾生物医药有限公司 | A kind of preparation method of B B-complex nourishing cream and its liposomal thing |
| CN110916038A (en) * | 2019-11-25 | 2020-03-27 | 利和(深圳)生物科技有限公司 | Preparation method of beverage for conditioning blood health |
| CN113576937A (en) * | 2021-08-06 | 2021-11-02 | 广州药妆日用化工有限公司 | Preparation method of arbutin solid nano-liposome |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102988194B (en) | 2014-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102988200B (en) | Liposome face-nourishing skin care product | |
| CN102988257B (en) | Liposome sun-screening skin care product | |
| CN102988194B (en) | Liposome essence | |
| ES2661728T3 (en) | Compositions and methods for improved skin care | |
| ES2710498T3 (en) | Collagen formulations to improve skin care | |
| CN111892667B (en) | Application of fluorine-containing compound modified cationic polymer in preparation of medical cosmetic and health care products | |
| US20170028184A1 (en) | Device and method of skin care and treatment via microneedles having inherent anode and cathode properties, with or without cosmetic or pharmacological compositions | |
| Akhtar | Vesicles: a recently developed novel carrier for enhanced topical drug delivery | |
| CN102871848B (en) | Pentacyclic triterpenoid cyclodextrin clathrate compound proliposome and preparation method thereof | |
| US20120184894A1 (en) | Patches and Methods for the Transdermal Delivery of Agents to Treat Hair Loss | |
| US20090324705A1 (en) | Phytonutrient compositions for topical use | |
| CN104666236A (en) | Moisturizing skincare mask | |
| Mezei | Liposomes and the skin | |
| CN109260035A (en) | Anti-ageing composition of a kind of whitening containing fullerene and preparation method thereof | |
| CN113521306B (en) | Transosome-exosome membrane fusion preparation with transdermal enhancement function and preparation method and application thereof | |
| CN104474551B (en) | Melatonin phosphatide complexes, its Percutaneously administrable preparation and preparation method thereof | |
| KR100976418B1 (en) | Mask pack using the water-vapor controllable sheet | |
| CN105963239A (en) | Emulsion capable of promoting skin to regenerate | |
| CN102988195B (en) | Liposome anti-hair loss preparation | |
| JPH08506804A (en) | Use of simaruuba extract for reducing mottled skin pigmentation or for enhancing the protective function of skin or for the preparation of skin cell culture medium and the composition thus obtained | |
| CN114259419A (en) | Compound composition containing recombinant collagen and preparation method and application thereof | |
| CN109222534A (en) | A kind of pillowcase | |
| CN102091013A (en) | Nanometer-element traditional Chinese medicine negative ion far-infrared effective skin-care product | |
| CN110448519B (en) | Flexible liposome of human fibroblast regulation culture solution and preparation method and application thereof | |
| CN102949328B (en) | Toning lotion with functions of anti-senile, wrinkle-dispelling and moisturizing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140917 Termination date: 20181210 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |