CN102349867A - Water-replenishing repairing cosmetic as well as preparation method and application thereof - Google Patents
Water-replenishing repairing cosmetic as well as preparation method and application thereof Download PDFInfo
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- CN102349867A CN102349867A CN2011103412616A CN201110341261A CN102349867A CN 102349867 A CN102349867 A CN 102349867A CN 2011103412616 A CN2011103412616 A CN 2011103412616A CN 201110341261 A CN201110341261 A CN 201110341261A CN 102349867 A CN102349867 A CN 102349867A
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Abstract
The invention discloses a water-replenishing repairing cosmetic as well as a preparation method and application thereof. In the invention, a skin water-replenishing repairing cosmetic with an excellent effect is prepared by combining traditional cosmetic effective raw materials with genetic engineering product biotic factors and adopting a vacuum freeze-drying technique. The cosmetic disclosed by the invention comprises water-replenishing repairing freeze-dried powder and water-replenishing repairing base liquid, wherein the freeze-dried powder comprises the following main components: grape seed extract, hydrolyzed red alga extract, low-molecular-weight hyaluronic acid, hydrolyzed collagen, recombinant human keratinocyte growth factor, recombinant human epidermal cell growth factor and micromolecular heparin sodium; and the base liquid comprises the following main components: hyaluronic acid (HA) with molecular weight of 1500000-2500000, methyl propanediol, honey extract, PCA (pyrrolidone carboxylic acid) sodium, dissolved proteinase, 1,2-hexylene glycol, oat beta-glucan, soybean isoflavone and the like. The water-replenishing repairing cosmetic disclosed by the invention can be used for daily skin nursing, can also be used through introduction by virtue of ultrasonic and other methods, and has the beautifying effects of replenishing skin water, repairing damaged cells caused by water deficiency and enhancing skin elasticity.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of skin moisturizing reparation cosmetics and its production and application.
Background technology
Moisture is one of human body important substance of depending on for existence, also is one of important component of human body, and the vital movements such as metabolism that lack the moisture human body just can be affected, and for example human body dehydration 10% just can threaten healthyly, and dehydration 20% will the causing death.Skin is as one of vitals of human body, and hydropenia also can not be ignored its influence and injury.Skin is covered in human body surface and had the greatest impact by extraneous factors such as environment; Very easily dry out; Can cause skin to follow the string after the skin hydropenia and reparative regeneration speed slows down and thereby skin problems such as shrivelled, aged, poor flexibility occur, so the replenishing water and preserving moisture reparation of skin become a theme of modern cosmetics.Moisturizing product major part in the market all is the cosmetics that cream frost, water preparation etc. obtain through the emulsifying means; Such cosmetics major part all is to add traditional wetting agent such as hyaluronic acid; Some plant extracts etc.; Such cosmetics can only play certain moisture-keeping function to skin from skin surface; But can not reach the skin deep layer; Solve water shortage problem from root, also have on the market at present and add cutaneous permeable agent, but effect is still undesirable.
Can produce injury to Skin Cell after the skin hydropenia; Damaged skin is repaired slow and very difficult normal reparation of speed; At this moment just need to add some cell biological factor isoreactivity materials and promote the skin regeneration reparation, traditional skin care item in the market since add all be macromole or be difficult to the arrival deep skin with the allogenic material of human body and play repair function.Also have at present one type to obtain biotic factor and reach repair, but owing to fail after repairing at the timely moisturizing lock of skin surface water, it is still not good that long-term effect is repaired in moisturizing through adding gene engineering method.The present invention is from these two angles; Conventional art is combined with biotechnology; The moisturizing of traditional skin care item lock water effect raw material and the biotic factor isoreactivity combinations of substances that genetic engineering obtains are disposed; Adopt compounded technology and freeze drying technology, obtained a respond well moisturizing and repaired the cosmetics of effect.
Summary of the invention
The objective of the invention is to combine conventional art and biotechnology; With traditional moisturizing lock water effect raw material and genetic engineered product configuration combination; Adopt Vacuum Freezing & Drying Technology, produce a do not add antiseptic and can long preservation the hydropenia skin is carried out the cosmetics that moisturizing is repaired.
Another purpose of the present invention is to provide above-mentioned moisturizing to repair the method for preparing of cosmetics.
A further object of the invention is to provide above-mentioned moisturizing to repair the application of cosmetics.
Above-mentioned purpose of the present invention is achieved through following technical scheme:
Cosmetics are repaired in a kind of moisturizing, comprise that lyophilized powder is repaired in moisturizing and basic liquid is repaired in moisturizing.Wherein said freeze-dried powder by the following percentages by mass of the total components: Grape Seed Extract? 0.1% to 2%, the hydrolysis extract of red algae? 0.5% to 4% low molecular weight hyaluronic acid? (HA Weight: 400,000 ~ 700,000) 0.05% to 1%, Hydrolyzed Collagen? 1% to 5%, recombinant human keratinocyte growth factor (Recombinant? Human? Keratinocyte? Growth? Factor-2, KGF-2)? 0.00001% ~ 0.001 %, recombinant human epidermal growth factor (Recombinant? Human? Epidermal? Growth? Factor, rhEGF) 0.00001% ~ 0.001%, low molecular weight heparin? 0.01% to 0.2%, stabilizing agent 1% to 15% margin for the injection level water; said basic solution by the following percentages by total mass meter components: Hyaluronic acid (HA molecular weight: 150 million to 2.5 million)? 0.01% to 0.4%, 0.5% methyl 4% propylene glycol, honey extract ? 0.5% ~ 5%, PCA sodium 0.5% to 5%,? dissolved protease 0.5% to 5% 1,2-hexanediol 0.3% 0.7% 1.5% oat β glucan 6% soy isoflavones 1% to 5%, balance deionized water or water for injection.
As a kind of preferred version, above-mentioned moisturizing is repaired in the cosmetics, and said stabilizing agent is one or more the mixture in freeze drying protectant, antioxidant, the soda acid adjustment agent.
As a kind of preferred version, above-mentioned moisturizing is repaired in the cosmetics, and said freeze drying protectant is one or more the mixture in glycerol, sucrose, trehalose, inositol, glucosan, lactose, PVP (polyvinylpyrrolidone), the glycine.
As a kind of preferred version; Above-mentioned moisturizing is repaired in the cosmetics, and said antioxidant is one or more the mixture in vitamin D, vitamin E, vitamin C, aminoacid, lecithin, protein hydrolysate, sodium thiosulfate, the sodium ascorbate protein hydrolysate.
As a kind of preferred version, above-mentioned moisturizing is repaired in the cosmetics, and said soda acid adjustment agent is one or more the mixture in sodium carbonate, phosphoric acid, EDTA, potassium citrate, tartaric acid, sorbic acid, the aminoacid.
As a kind of most preferably scheme, above-mentioned moisturizing is repaired in the cosmetics, and said stabilizing agent comprises that the concentration according to the mass percent meter is one or more the mixture in 1% ~ 20% glycine, trehalose, glycerol, sucrose, the lactose; According to the concentration of mass percent meter is one or more the mixture in 1% ~ 10% vitamin D, vitamin E, protein hydrolysate, the sodium thiosulfate; Molar concentration is one or more the mixture in the sodium carbonate, phosphoric acid, potassium citrate, aminoacid of 2 ~ 30mmol/L.
Concrete effect and relative theory that each component in the cosmetics is repaired in moisturizing of the present invention are:
Semen Vitis viniferae extract is rich in antioxidant, can remove the free radical of infringement cell membrane in the body, prevents that cell membrane from damaging the back dehydration, can also regulate the permeability of blood capillary, makes cell and tissue metabolism normal, and skin health is rich in moisture and elasticity.
The material that hydrolysis red algae extract extracts in the livings red algae for the sea proves that after deliberation this material can promote to use the blood circulation at position, accelerates the absorption that metabolic speed also can promote nutrient substance, makes the hydropenia damaged skin elasticity of getting well as early as possible.
Hyaluronic acid extensively is present between human tissue cell, can play the effect of water conservation.The micromolecule hyaluronic acid deep layer that can penetrate to the skin promotes the propagation and the differentiation of cell, plays the effect of deep layer moisturizing and reparation.
Collagen protein is a kind of transparence material that is made up of three spiral type peptide chain polymerizations, and these three kinds of helical structures can pin moisture and nutrition firmly.Because itself and horny layer structural similarity, it and skin have the good affinity and the compatibility, and porous is gone into skin epidermis, and nutrition is provided; It can combine with the water in the horny layer simultaneously, forms network structure, pins moisture, makes moisture of skin sufficient, and skin presents healthy attitude.
Recombinant human horny cell growth factor-2 belongs to fibroblast growth family; Only act on epithelial cell, but horny layer of epidermis is repaired in the growth of the ripe horn cell of obvious stimulation people; Have preserve moisture, radioprotective and antiinflammatory action, can significantly strengthen the ability that skin is resisted extraneous pessimal stimulation.
But mucopolysaccharide biomacromolecule materials such as the synthetic hyaluronic acid of recombinant human epidermal growth factor significant stimulation Skin Cell; Effectively pin skin moisture; And can promote the propagation of various kinds of cell in the skin histology (like epidermis cell, fibroblast and neurocyte etc.); Be excited into fibrocyte and produce newborn collagen protein; Improve skin elasticity, make skin present healthy attitude.
Low molecular heparin is the inherent polysaccharide component of human body; Skin there are not any ill effect and stimulation; Anti thrombotic action is not only arranged; Also have antiinflammatory and anti-allergic effects; Can increase dermovascular permeability; Improve local blood circulation, help the drainage of the nutrition supply and the metabolic waste of skin, skin is had good health care and maintenance action.A year preceding Low molecular heparin just is widely used in clinical the America and Europe surplus in the of ten.In recent years Low molecular heparin is used for the new focus that skin nursing has become external cosmetic industry, product comprises nourishing cream, eye cream, the acne of dispelling product etc.
The method for preparing that the cosmetics lyophilized powder is repaired in moisturizing of the present invention comprises the steps: to use the injection stage water with each material dissolution mixing of these cosmetics (factor raw material needs dissolving mixing in being lower than 25 ℃ of water); 0.22 be sub-packed in the clean cillin bottle behind the μ m membrane filtration; False add plugs in vacuum freeze drier; Vacuum lyophilization 15 ~ 35h; Lid pack is pricked in tamponade sealing back under the vacuum condition, obtains moisturizing of the present invention and repairs the cosmetics lyophilized powder.
As a kind of preferred version; In the above-mentioned method for preparing; The process conditions of said vacuum lyophilization are: goods are carried out pre-freeze; Make its temperature reduce to-50 ℃; Temperature fall time is 4 ~ 8h, is evacuated to 0.3mbar, and subliming by heating is dry; Be 15 ~ 25h drying time, and the water sublimed in goods is complete.
After the method for preparing of moisturizing reparation cosmetics basic liquid of the present invention comprises the steps: to use injection stage water or deionized water with each material dissolution mixing of these cosmetics; 0.22 packing after the degerming of μ m membrane filtration, Zha Gai obtain moisturizing of the present invention and repair the cosmetics basic liquid.
The trial method that cosmetics are repaired in moisturizing of the present invention is: after adopting basic liquid dissolving of the present invention lyophilized powder mix homogeneously of the present invention, being sprayed on needs the nursing position extremely to absorb fully with the have gentle hands forlement.Product of the present invention is if method importing effects such as use ultrasound wave are better.
Moisturizing of the present invention is repaired cosmetics and can be used for replenishing moisture of skin and repairing hydropenia damaged skin cell, makes skin be full of elasticity and presents healthy young attitude.
Compared with prior art, the present invention has following beneficial effect:
The present invention is with the effect raw material and the genetic engineered product biotic factor configuration combination of traditional cosmetics; Not only macromolecular substances carries out moisturizing lock water at skin surface; And small-molecule substances such as biotic factor penetrate into epidermis cell and repair moisturizing; All moisture is sufficient from the inside to the outside to make skin, and skin health is flexible again.Utilize Vacuum Freezing & Drying Technology simultaneously, the activity of the biotic factor isoreactivity material that in removing product, has kept in most moisture being added has increased the shelf-life of such cosmetics and the convenient transportation of this product is carried.
The specific embodiment
Come further to explain the present invention below in conjunction with embodiment, but embodiment does not do any type of qualification to the present invention.
Embodiment 1
Lyophilized powder of the present invention is configured to:
Take by weighing 50g Semen Vitis viniferae extract, 100g hydrolysis red algae extract, 30g small-molecular weight hyaluronic acid, 100g hydrolytic collagen, 0.05g recombinant human horny cell growth factor-2,0.03g recombinant human epidermal growth factor, 5g low molecular sodium heparin, 600g stabilizing agent; Add 10000ml injection stage water; The degerming of mix homogeneously after-filtration is put into lyophilizing 15 ~ 35h on the vacuum freeze drier in the 3.2ml fill behind the false add plug in cillin bottle.
Wherein stabilizer formula is: 200g glycine, 400g protein hydrolysate, 10mM phosphoric acid
Being configured to of basic liquid of the present invention:
Basic liquid prescription: (wt%)
Hyaluronic acid 0.2
Methyl propanediol 1.0
Mel extract 3.0
PCA sodium 1.5
Soluble protein enzyme 2.5
1,2 hexanediol 0.4
Herba bromi japonici beta glucan 4.0
Soybean isoflavone 1.5
Surplus is water for injection or deionized water.
The degerming of above-mentioned prescription dissolving after-filtration is carried out fill, is rolled lid by the 15ml/ bottle.During use, get final product to absorbing fully smearing skin massaging behind above-mentioned one bottle of basic liquid and the one bottle of lyophilized powder mixing, ultrasound wave importing effect is better.
Embodiment 2
Lyophilized powder of the present invention is configured to:
Take by weighing 100g Semen Vitis viniferae extract, 80g hydrolysis red algae extract, 50g small-molecular weight hyaluronic acid, 200g hydrolytic collagen, 0.08g recombinant human horny cell growth factor-2,0.05g recombinant human epidermal growth factor, 8g low molecular sodium heparin, 500g stabilizing agent; Add 10000ml injection stage water; The degerming of mix homogeneously after-filtration is put into lyophilizing 15 ~ 35h on the vacuum freeze drier in the 3.2ml fill behind the false add plug in cillin bottle.
Wherein stabilizer formula is: 200g trehalose, 300g sodium thiosulfate, 15mM sodium carbonate
Being configured to of basic liquid of the present invention:
Basic liquid prescription: (wt%)
Hyaluronic acid 0.25
Mel extract 2.0
PCA sodium 3.0
Soluble protein enzyme 3.0
1,2 hexanediol 0.5
Herba bromi japonici beta glucan 2.0
Soybean isoflavone 2.0
Surplus is water for injection or deionized water.
The degerming of above-mentioned prescription dissolving after-filtration is carried out fill, is rolled lid by the 15ml/ bottle.During use, above-mentioned one bottle of basic liquid get final product to absorbing fully with smearing skin massaging after one bottle of lyophilized powder mixes, ultrasound wave importing effect is better.
Embodiment 3
Lyophilized powder of the present invention is configured to:
Claim 80g Semen Vitis viniferae extract, 200g hydrolysis red algae extract, 80g small-molecular weight hyaluronic acid, 150g hydrolytic collagen, 0.03g recombinant human horny cell growth factor-2,0.08g recombinant human epidermal growth factor, 5g low molecular sodium heparin, 500g stabilizing agent; Add 10000ml injection stage water; The degerming of mix homogeneously after-filtration is put into lyophilizing 15 ~ 30h on the vacuum freeze drier in the 3.2ml fill behind the false add plug in cillin bottle.
Wherein stabilizer formula is: 200g sucrose, 300g vitamin D, 10mM potassium citrate
Being configured to of basic liquid of the present invention:
Basic liquid prescription: (wt%)
Hyaluronic acid 0.3
Methyl propanediol 2.5
Mel extract 3.5
PCA sodium 2.0
Soluble protein enzyme 3.0
Herba bromi japonici beta glucan 3.5
Soybean isoflavone 4.0
Surplus is water for injection or deionized water.
The degerming of above-mentioned prescription dissolving after-filtration is carried out fill, is rolled lid by the 15ml/ bottle.During use, above-mentioned one bottle of basic liquid get final product to absorbing fully with smearing skin massaging after one bottle of lyophilized powder mixes, ultrasound wave importing effect is better.
The raw material that is used in the embodiment of the invention, instrument, equipment and aid all are commercially available.
Cosmetic result testing program of the present invention designs as follows:
Experiment product: cosmetics are repaired in moisturizing of the present invention
The blank article: the present invention of employing physiological saline solution does not add the lyophilized powder of functional component
Commercially available reference substance: essence is repaired in commercially available certain brand moisturizing
Experiment product of the present invention, blank article are placed the facial nursing position that needs, extremely absorb fully with the have gentle hands forlement.Carry out following cosmetic result test respectively.
1. moisturizing repairing test
Choose women 150 people of 25 ~ 45 years old dry hydropenia of face skin, be divided into 3 at random
Group, every group 50 people, every group is used above-mentioned experiment product respectively, and blank article and commercially available reference substance continuous 2 months, are estimated its moisturizing repairing effect respectively then.
2. safety testing
In above-mentioned moisturizing repairing test, observe its zest simultaneously to skin, have or not allergy and other untoward reaction.
Cosmetic result result of the test of the present invention is following.
1. moisturizing repairing test result:
It is remarkable to find out that by last table cosmetic industry is repaired in moisturizing of the present invention, and the blank article that do not contain functional component do not have moisturizing to repair effect basically, and moisturizing repairing effect of the present invention significantly is better than the commercially available prod.
2. safety testing result:
After 200 people used, not finding had pair skin irritation, only has 4 people to occur slightly
Allergy, 3 people occur that itch in the part or flushing.
Product stability test of the present invention and result:
1. stability testing method is measured the activity of biotic factor isoreactivity material in the product after room temperature is placed the corresponding time for adopting the cell culture mtt assay.
2. stability test result
Can find out that from last table product stability of the present invention is good in 2 years.
Claims (9)
1. cosmetics are repaired in a moisturizing; Comprise that lyophilized powder is repaired in moisturizing and basic liquid is repaired in moisturizing; It is characterized in that said lyophilized powder is by forming according to the component of mass percent meter as follows: Semen Vitis viniferae extract 0.1% ~ 2%; Hydrolysis red algae extract 0.5% ~ 4%; Small-molecular weight hyaluronic acid 0.05% ~ 1%; Hydrolytic collagen 1% ~ 5%; Recombinant human horny cell growth factor-2 0.00001% ~ 0.001%; Recombinant human epidermal growth factor 0.00001% ~ 0.001%; Low molecular sodium heparin 0.01% ~ 0.2%, stabilizing agent 1% ~ 15% surplus is the injection stage water; Said basic liquid is by forming by the component of gross mass percent as follows: hyaluronic acid 0.01% ~ 0.4%; Methyl propanediol 0.5% ~ 4%; Mel extract 0.5% ~ 5%; PCA sodium 0.5% ~ 5%, soluble protein enzyme 0.5% ~ 5%, 1; 2 hexanediol 0.3% ~ 0.7%; Herba bromi japonici beta glucan 1.5% ~ 6%, soybean isoflavone 1% ~ 5%, surplus is deionized water or water for injection.
2. cosmetics are repaired in moisturizing according to claim 1, it is characterized in that said stabilizing agent comprises one or more mixture of freeze drying protectant, antioxidant and soda acid adjustment agent.
3. cosmetics are repaired in moisturizing according to claim 2, it is characterized in that said freeze drying protectant is one or more the mixture in glycerol, sucrose, trehalose, inositol, glucosan, lactose, PVP (polyvinylpyrrolidone), the glycine.
4. cosmetics are repaired in moisturizing according to claim 2, it is characterized in that said antioxidant is one or more the mixture in vitamin D, vitamin E, vitamin C, aminoacid, lecithin, protein hydrolysate, sodium thiosulfate, the sodium ascorbate protein hydrolysate.
5. cosmetics are repaired in moisturizing according to claim 2, it is characterized in that said soda acid adjustment agent is one or more the mixture in sodium carbonate, phosphoric acid, EDTA, potassium citrate, tartaric acid, sorbic acid, the aminoacid.
6. cosmetics are repaired in moisturizing according to claim 2, it is characterized in that said stabilizing agent comprises that concentration according to the mass percent meter is one or more the mixture in 1% ~ 20% glycine, trehalose, glycerol, sucrose, the lactose; According to the concentration of mass percent meter is one or more the mixture in 1% ~ 10% vitamin D, vitamin E, protein hydrolysate, the sodium thiosulfate; Molar concentration is one or more the mixture in the sodium carbonate, phosphoric acid, potassium citrate, aminoacid of 2 ~ 30mmol/L.
7. the method for preparing that cosmetics are repaired in the said moisturizing of arbitrary claim in the claim 1 ~ 6; It is characterized in that the method for preparing that comprises the steps: (1) said lyophilized powder comprises the steps: to use the injection stage water with each material dissolution mixing of these cosmetics; Be sub-packed in after the filtration sterilization in the clean cillin bottle; False add plugs in vacuum freeze drier; Vacuum lyophilization 15 ~ 35h; Fully dry until water sublimed; Lid pack is pricked in tamponade sealing back under the vacuum condition, obtains said moisturizing and repairs the cosmetics lyophilized powder; (2) method for preparing of said cosmetics basic liquid comprises the steps: to use injection stage water or deionized water with each material dissolution mixing of these cosmetics, and packing after the filtration sterilization, Zha Gai obtain said moisturizing and repair the cosmetics basic liquid; (3) said moisturizing being repaired lyophilized powder and said moisturizing repairs basic liquid and mixes and can obtain a kind of moisturizing reparation cosmetics.
8. the method for using that cosmetics are repaired in the said moisturizing of arbitrary claim in the claim 1 ~ 6 is characterized in that cosmetics are repaired in said moisturizing to be sprayed on and need extremely to absorb fully with the have gentle hands forlement at the nursing position; Said moisturizing is repaired cosmetics and also can be used ultrasound wave importing method to use.
9. the application of cosmetics is repaired in said according to Claim 8 moisturizing, it is characterized in that having additional moisture of skin and repairs hydropenia damaged skin cell, makes moisture of skin sufficient, is full of the beauty functions that elasticity presents healthy young attitude.
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