CN103932911A - Anti-wrinkle and whitening freeze-dried instant cosmetic and preparation method thereof - Google Patents
Anti-wrinkle and whitening freeze-dried instant cosmetic and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the composition of a cosmetic and a preparation method thereof, and in particular relates to an anti-wrinkle and whitening freeze-dried instant cosmetic and a preparation method thereof. In order to solve the problem of instability due to that raw materials in the existing whitening and anti-aging products are liable to hydrolyze, oxidize and the like, the invention provides an anti-wrinkle and whitening freeze-dried instant cosmetic and a preparation method thereof. The cosmetic comprises the following components: 2-16 parts by weight of excipient, 0.1-10 parts by weight of sodium hyaluronate, 0.0002-0.008 part by weight of EGF (epidermal growth factor), 0-5 parts by weight of VC (vitamin C), 0-0.5 part by weight of collagen, 0-3 parts by weight of alpha-arbutin, 0-0.5 part by weight of D-panthenol and 0-0.3 parts by weight of alpha-lipoic acid. The cosmetic is stable in characters and good in anti-wrinkle and whitening effects, and the preparation method is simple, and easy to operate.
Description
Technical field
The present invention relates to composition and the preparation method of cosmetics, particularly a kind of crease-resistant, whitening freeze-dried instant cosmetics and preparation method thereof.
Background technology
Skin is the protective barriers,primary of human body, can protect human body to avoid external irritant.In the time of skin aging, there will be and follow the string, blackening, the phenomenon that chap is dry.In order to protect skin, slow down the aging of skin.People often adopt cosmetics to carry out moisturizing, crease-resistant, also can carry out whitening to skin for beauty applies some make up.
The form of existing crease-resistant, most employing emulsifiable pastes of whitening product, emulsion, contains UV absorbent, antiseptic etc. conventionally, and these materials are known from experience and had side effects people.
At present, along with the development of extractive technique and biotechnology, the modern biotechnology development innovations such as genetic engineering, cell engineering, fermentation engineering and enzyme engineering, utilize the various active cosmetic compositions that process in microorganism, animals and plants being widely used in cosmetics.The better affinity of these new raw materials and human skin, be more conducive to skin absorb, produce good skin effect, traditional daily chemical product progressively by pure natural, high bioactivity products substitution, be the cosmetics developing direction in future.
But, the active substance that these extractions or fermentation technology are produced, can bring into play effect, its activity of placing one's entire reliance upon, conventionally, these active substances are comparatively responsive for moisture and oxygen, water energy stimulating activity usefulness, but in water, active storage life also obviously shortens, and uses conventional State of cosmetics, such as unguentum, cream, Emulsion etc., biological activity is difficult to ensure.
Freeze-dried instant technology is the cutting edge technology growing up on Vacuum Freezing & Drying Technology basis.Greatly different from common injection prescription of freeze-drying powder and preparation technology, it be by quantitative separating after functional component and adjuvant dosing in a fixed mold, by medicinal liquid be frozen into solid-state, then evacuation by moisture by solid state directly distillation be that steam lyophilizing is anhydrated, make the chip solid preparation of high porosity.
Summary of the invention
In order to solve the instable problem such as existing whitening and anti-aging product Raw facile hydrolysis, oxidation, the invention provides a kind of crease-resistant, whitening freeze-dried instant cosmetics and preparation method thereof.This is crease-resistant, the character of whitening freeze-dried instant cosmetics is stable, crease-resistant and whitening effective, and its preparation method is simple, easy operating.
In order to solve the problems of the technologies described above, the present invention adopts following technical proposals:
The invention provides a kind of crease-resistant, whitening freeze-dried instant cosmetics, comprise following component:
Excipient, 2-16 weight portion;
Hyaluronate sodium, 0.1-10 weight portion;
EGF, 0.0002～0.008 weight portion;
VC, 0～5 weight portion;
Collagen protein, 0～0.5 weight portion;
Alpha-arbutin, 0～3 weight portion;
D-panthenol, 0～0.5 weight portion;
Alpha-lipoic acid, 0～0.3 weight portion.Aforementioned excipients comprises PVP-K30 and mannitol.Wherein, PVP-K30 is 0.1～10 weight portion, and mannitol is 0.1～10 weight portion.The total amount of PVP-K30 and mannitol is 2-16 weight portion.Further, aforementioned excipients is 7-16 weight portion.
Further, above-mentioned cosmetics are made up of following component:
Excipient, 2-16 weight portion;
Hyaluronate sodium, 0.1-10 weight portion;
EGF, 0.0002～0.008 weight portion;
VC, 0～5 weight portion;
Collagen protein, 0～0.5 weight portion;
Alpha-arbutin, 0～3 weight portion;
D-panthenol, 0～0.5 weight portion;
Alpha-lipoic acid, 0～0.3 weight portion.Aforementioned excipients is made up of PVP-K30 and mannitol.Wherein, PVP-K30 is 0.1～10 weight portion, and mannitol is 0.1～10 weight portion.The total amount of PVP-K30 and mannitol is 2-16 weight portion.
Further, crease-resistant, whitening freeze-dried instant cosmetics provided by the invention, comprise following component:
Excipient, 7-16 weight portion;
Hyaluronate sodium, 0.2-2 weight portion;
EGF, 0.001～0.008 weight portion;
VC, 2.5～5 weight portions;
Collagen protein, 0.2～0.5 weight portion;
Alpha-arbutin, 0.3～3 weight portion;
D-panthenol, 0.5 weight portion;
Alpha-lipoic acid, 0.3 weight portion.Aforementioned excipients comprises PVP-K30 and mannitol.Wherein, PVP-K30 is 3～10 weight portions, and mannitol is 4～10 weight portions.
Further, crease-resistant, whitening freeze-dried instant cosmetics provided by the invention, comprise following component:
Excipient, 7 weight portions;
Hyaluronate sodium, 0.5 weight portion;
EGF, 0.001 weight portion;
VC, 2.5 weight portions;
Collagen protein, 0.2 weight portion;
Alpha-arbutin, 0.3 weight portion;
D-panthenol, 0.5 weight portion;
Alpha-lipoic acid, 0.3 weight portion.Aforementioned excipients comprises PVP-K30 and mannitol.Wherein, PVP-K30 is 3 weight portions, and mannitol is 4 weight portions.
The activity value of the EGF using in above-mentioned cosmetics is: 5 × 10
5iU/mg.
In above-mentioned cosmetics, the effect of each raw material is as follows:
EGF (epithelical cell growth factor), by 53 amino living cells that form, can stimulate the tyrosine phosphorylation of EGFR, reaches and repairs hypertrophy skin cells of superficial layer, and injured, impaired epidermis skin is had to excellent curative effect.The maximum feature of EGF is the proliferation and differentiation that can promote cell, thereby replaces old and feeble and dead cell with newborn cell.EGF can also stop blooding, and has skin and the mucosa wound healing of acceleration, and anti-inflammatory analgesic prevents effect of ulcer.EGF is material naturally existing in human body skin, at infant period, EGF rich content in skin, large to epidermis cell division, the facilitation of breeding, regenerative cell in skin shared ratio much larger than the ratio of aging death cell.Thereby skin smooth, exquisiteness, ruddy, plentiful and flexible; With advancing age, the expression of human body growth hormone gene weakens gradually, and in skin, the content of EGF reduces gradually, and the facilitation of epidermis cell division, propagation is reduced gradually, in skin, the sum of cell reduces gradually, and the shared ratio of new cell is gradually lower than the ratio of senile cell.The biomacromolecule such as collagen protein and hyaluronic acid also reduces gradually, thereby skin quality declines day by day, engenders the aging phenomenons such as mottle deposition, wrinkle increase, dry unglazed, elasticity attenuation.Therefore, in human body skin EGF content number directly determining the young degree of skin.
EGF is a kind of biological activity protein, and place one's entire reliance upon its activity of its effect, does not have activated EGF like water off a duck's back.After EGF is exposed in air or dissolves, determine that its active disulfide bond can oxidized fracture, molecular structure changes (in air and solution, all containing aerobic).Thereby can lose activity inefficacy in the short time, and its use need to just can have effect under liquid condition, the activity of second day declines more than 50% under liquid condition, within 5 days, substantially there is no effectiveness afterwards.Therefore, generally freeze with stock solution or lyophilized powder mode is preserved.
Vitamin C: claim again vitamin C, ascorbic acid.English name: Vitamin C, Ascorbic Acid.Within 1907, Norway's chemist's Halkett is found in Fructus Citri Limoniae juice, have whitening, crease-resistant, desalinate mottle and control the effects such as oily toxin expelling.
Vitamin C is the most unsettled a kind of vitamin, is clear crystal, and 190～192 DEG C of fusing points are soluble in water, and it is acid that aqueous solution is, and chemical property is more active, and heat, alkali and heavy metal ion are easily decomposed, and to photaesthesia, are a kind of antioxidant.
Ascorbic biological activity is the enediol structure due to it, and this structure shows strong reproducibility.Vitamin C is Quick Oxidation and decomposition in aqueous solution.Therefore, vitamin C is easy to oxidized, particularly under the condition of aerobic and illumination.In order to address this problem, a large amount of vitamin C derivatives are synthesized, but still have the problem of conversion, malabsorption.
α ?thioctic acid: faint yellow solid powder, more responsive to light.It is a kind of antioxidant.
Hyaluronate sodium: white powder, there is special water retention, moisture-holding capacity, up to 100 times of itself weight, is the best material of occurring in nature moisture retention of finding at present, is called as desirable nature moisturizing factor.It can improve skin-nourishing metabolism, acts on skin surface, and micromolecule hyaluronic acid can infiltrate corium, there is slight expansion blood capillary, increase blood circulation, improve intermediate supersession, promote skin-nourishing Absorption, can increase skin elasticity, delay skin aging.
The effect of collagen protein in cosmetics is wrinkle resistant, moisturizing, makes that skin is plentiful, wrinkle is unfolded, and effectively prevents skin aging.
Alpha-arbutin is to be obtained by natural uva ursi extraction, is a kind of pure, water miscible active component, can promote skin whitening and be applicable to any skin.Alpha-arbutin suppresses the formation of epidermal melanin by the Oxidation of blocking-up tryrosinase and DOPA, whitening function is effective fast.
D-panthenol (dexpanthenol), can cure skin injury, to eczema, daylight sunburn, insect bite, there is certain curative effect, and has certain Detoxication, is mainly used as the conditioner of skin care item.
Mannitol is used as wetting agent in cosmetics.
PVP-K30 is used as film former in cosmetics, thickening agent and binding agent.
Wetting agent in cosmetics, is beneficial to skin to having the absorption of activated feedstock of wrinkle resistant white-skinned face function in cosmetics.
After deliberation, above Material Compatibility is good, without incompatibility.
Above-mentioned cosmetics are made freeze dried powder or tablet, and preparation technology is as follows:
(1) the solid-state raw material, taking except EGF mixes.
(2), to adding in said mixture appropriate purified water to stir, make mix wetting.
(3), wet stock is mixed.
(4), add EGF and other liquid material, add purified water quantitatively to 100 weight portions, mix homogeneously.
(5) mixture, step 4 being obtained is sub-packed in in type bubble-cap with 0.1ml-1ml/ unit.
(6), mixture after subpackage is placed in to subzero 40 DEG C to subzero 80 DEG C and is frozen into solid.
(7), freezing being placed on carried out sublimation drying in vacuum freeze.
(8), use packer heat sealed package.
Further, in above-mentioned steps (3), wet stock is placed in to mulser high speed and mixes.
Further, in above-mentioned steps (5), mixture is sub-packed in in type bubble-cap with 0.35ml/ unit.
Further, the dry run of above-mentioned cosmetics is carried out under low pressure or vacuum condition.
The present invention also provides a kind of crease-resistant, whitening freeze-dried instant cosmetics, is made up of following component:
Excipient is 7 weight portions, and VC is 2.5 weight portions, and hyaluronate sodium is 0.5 weight portion, and alpha-arbutin is 0.3 weight portion, and D-panthenol is 0.5 weight portion, and EGF is 0.0004 weight portion.Aforementioned excipients comprises PVP-K30 and mannitol.Wherein, PVP-K30 is 3 weight portions, and mannitol is 4 weight portions.These cosmetics are also referred to as instant of whitening anti-acne.
The preparation technology that above-mentioned whitening anti-acne is instant is as follows:
(1), take excipient, VC, hyaluronate sodium, alpha-arbutin mixing.
(2), to adding in said mixture appropriate purified water to stir, make mix wetting.
(3), wet stock is mixed.
(4), add D-panthenol, EGF, then add purified water quantitatively to 100 weight portions, mix homogeneously.
(5) mixture, step 4 being obtained is sub-packed in in type bubble-cap with 0.35ml/ unit.
(6), mixture after subpackage is placed in to-70 DEG C and is frozen into solid.
(7), freezing being placed in vacuum freeze carry out sublimation drying, obtains a slice chip solid in each unit.
(8), use packer heat sealed package.
Further, in above-mentioned steps (3), wet stock is placed in to mulser high speed and mixes.
The present invention also provides a kind of crease-resistant, whitening freeze-dried instant cosmetics, is made up of following component:
Excipient is 7 weight portions, and hyaluronate sodium is 0.5 weight portion, and the content of collagen protein is 0.2 weight portion, and the content of alpha-lipoic acid is 0.3 weight portion, and EGF is 0.001 weight portion.Aforementioned excipients comprises PVP-K30 and mannitol.Wherein, PVP-K30 is 3 weight portions, and mannitol is 4 weight portions.These cosmetics are also referred to as instant of wrinkle removing skin care.
The preparation technology that described wrinkle removing skin care is instant is as follows:
(1), take excipient, hyaluronate sodium, collagen protein, thioctic acid mixing.
(2), to adding in said mixture appropriate purified water to stir, make mix wetting.
(3), wet stock is mixed.
(4), add EGF, add quantitatively to 100 of purified water weight portion, mix homogeneously.
(5) mixture, step 4 being obtained is sub-packed in in type bubble-cap with 0.35ml/ unit.
(6), mixture after subpackage is placed in to-70 DEG C and is frozen into solid.
(7), freezing being placed in vacuum freeze carry out sublimation drying, obtains a slice chip solid in each unit.
(8), use packer heat sealed package.
Further, in above-mentioned steps (3), wet stock is placed in to mulser high speed and mixes.
The using method of cosmetics provided by the invention is as follows, takes out a slice tablet in independent packaging, splashes into appropriate purified water to tablet surface, stirs and makes to be all uniformly dissolved to point gently, is applied to face, pats gently skin, until absorb completely.
Further, first clean face, get afterwards cosmetic product provided by the invention, tear from the side the aluminium foil of packaging, take out a slice with the hands being dried and be placed in the centre of the palm, splash into appropriate purified water to tablet surface, stir and make to be all uniformly dissolved gently with finger, be applied to face, pat gently skin, until absorb completely.Normal use amount suggestion: once a day, an a slice, is used before sleeping.
Compared with containing the cosmetics of liquid, freeze-dried instant cosmetics have following remarkable advantage: 1. production process is carried out under vacuum condition, oxidizable for some, and the material of facile hydrolysis has good protective effect; 2. can make albumen, microbiology class composition enter resting state fast and degeneration not occur or lose activity, biological tissue and cellularity are not damaged substantially, can effectively protect the stability of thermal sensitivity composition; 3. loose, the color of freeze-dried products form after dry does not change substantially, can dissolve fast and recover physicochemical property and the biological activity of original aqueous solution after adding water; 4. goods water content after lyophilizing is extremely low, and not only stability improves, and contaminated chance reduces greatly; 5. store and convenient transportation, the shelf-life extends.6. accurate quantification, packs separately, avoids repeatedly using and polluting for every.7. open simply, safety, new packing, easy to carry.
Compared with prior art, the character of crease-resistant, whitening freeze-dried instant cosmetics provided by the invention is stable, crease-resistant and whitening effective, and its preparation method is simple, easy operating.
Detailed description of the invention
In order to be more readily understood technical scheme of the present invention and advantage, below embodiments of the invention are elaborated.
PVP-K30 used in embodiment below, mannitol, hyaluronate sodium, EGF, VC, collagen protein, alpha-arbutin, D-panthenol, alpha-lipoic acid source is as follows:
| Name of material | Model | Manufacturer |
| PVP-K30 | Pharmaceutical grade | Germany BASF |
| Mannitol | Pharmaceutical grade | Guangxi Nanning Chemical Pharmaceutical Ltd. |
| Hyaluronate sodium | 8000 dalton | Focus bio tech ltd, Shandong |
| EGF | Cosmetics-stage | Beijing Hua Aodakang biotechnology development corporation, Ltd. |
| VC | Pharmaceutical grade | The Shi Yao group Pharmaceutical of supporting one's family |
| Collagen protein | 5000 dalton | Beijing Tai Aitai biotechnology company limited |
| Alpha-arbutin | Cosmetics-stage | Guangzhou Ning Yida Chemical Co., Ltd. |
| D-panthenol | Cosmetics-stage | Yan Tuo bio tech ltd, Shanghai |
| Alpha-lipoic acid | Pharmaceutical grade | Xi'an Jin Lv biotechnology company limited |
Embodiment 1
According to a kind of crease-resistant, whitening freeze-dried instant cosmetics of method preparation provided by the invention, comprise that component is as follows:
PVP-K30，0.1g；
Mannitol, 10g;
Hyaluronate sodium, 0.1g;
EGF，0.0002g；
VC，0；
Collagen protein, 0;
Alpha-arbutin, 3g;
D-panthenol, 0.5g;
Alpha-lipoic acid, 0.
Preparation technology is as follows:
(1), add appropriate purified water to mix above-mentioned solid feed except EGF,
(2), add EGF and other liquid material, by purified water quantitatively to 100g, mix homogeneously.
(3) mixture, step (2) being obtained is sub-packed in in type bubble-cap with 0.35ml/ unit.
(4), mixture after subpackage is placed in to-70 DEG C and is frozen into solid.
(5), freezing being placed in vacuum freeze carry out sublimation drying, obtains loose chip solid.
(6), use packer heat sealed package.
Embodiment 2
A kind of crease-resistant, the whitening freeze-dried instant cosmetics of method preparation that provide according to embodiment 1, comprise that component is as follows:
PVP-K30，10g；
Mannitol, 0.1g;
Hyaluronate sodium, 10g;
EGF，0.008g；
VC，5g；
Collagen protein, 0.5g;
Alpha-arbutin, 0g;
D-panthenol, 0g;
Alpha-lipoic acid, 0.3g.
Embodiment 3
A kind of crease-resistant, the whitening freeze-dried instant cosmetics of method preparation that provide according to embodiment 1, comprise that component is as follows:
PVP-K30，5g；
Mannitol, 5g;
Hyaluronate sodium, 5g;
EGF，0.004g；
VC，2.5g；
Collagen protein, 0.3g;
Alpha-arbutin, 1.5g;
D-panthenol, 0.2g;
Alpha-lipoic acid, 0.15g.
Embodiment 4
A kind of crease-resistant, the whitening freeze-dried instant cosmetics of method preparation that provide according to embodiment 1, comprise that component is as follows:
PVP-K30，3g；
Mannitol, 4g;
Hyaluronate sodium, 0.5g;
EGF，0.001g；
VC，2.5g；
Collagen protein, 0.2g;
Alpha-arbutin, 0.3g;
D-panthenol, 0.5g;
Alpha-lipoic acid, 0.3g.
Embodiment 5
A kind of crease-resistant, the whitening freeze-dried instant cosmetics of method preparation that provide according to embodiment 1, comprise that component is as follows:
PVP-K30，10g；
Mannitol, 6g;
Hyaluronate sodium, 2g;
EGF，0.008g；
VC，5g；
Collagen protein, 0.5g;
Alpha-arbutin, 3g;
D-panthenol, 0.5g;
Alpha-lipoic acid, 0.3g.
Embodiment 6
A kind of crease-resistant, the whitening freeze-dried instant cosmetics of method preparation that provide according to embodiment 1, comprise that component is as follows:
PVP-K30，6g；
Mannitol, 10g;
Hyaluronate sodium, 0.2g;
EGF，0.005g；
VC，4g；
Collagen protein, 0.4g;
Alpha-arbutin, 2g;
D-panthenol, 0.5g;
Alpha-lipoic acid, 0.3g.
Embodiment 7
The present invention also provides a kind of crease-resistant, whitening freeze-dried instant cosmetics, and its component is as follows:
PVP-K30 is 3g, and mannitol is 4g, and VC is 2.5g, and hyaluronate sodium is 0.5g, and alpha-arbutin is 0.3g, and D-panthenol is 0.5g, and EGF is 0.0004g.
The preparation technology of above-mentioned whitening anti-acne sheet is as follows:
(1), take PVP-K30, mannitol, VC, hyaluronate sodium, alpha-arbutin and mix,
(2), to adding in said mixture appropriate purified water to stir, make mix wetting,
(3), by wet stock mix,
(4), add D-panthenol, EGF, then add purified water standardize solution to 100g, mix homogeneously,
(5), mixture that step 4 is obtained is sub-packed in in type bubble-cap with 0.35ml/ unit,
(6), mixture after subpackage be placed in to-70 DEG C be frozen into solid,
(7), freezing being placed in vacuum freeze carry out sublimation drying, the chip solid that must loosen in each unit,
(8), use packer heat sealed package.
The cosmetics that the present embodiment obtains are also referred to as instant of whitening anti-acne.
Embodiment 8
The present invention also provides a kind of crease-resistant, whitening freeze-dried instant cosmetics sheet, and its component is as follows:
PVP-K30 is 3g, mannitol be 4g, hyaluronate sodium is 0.5g, the content of collagen protein is 0.2g, the content of alpha-lipoic acid is 0.3g, EGF is 0.001g.
Described preparation technology crease-resistant, whitening freeze-dried instant cosmetics is as follows:
(1), take PVP-K30, mannitol, hyaluronate sodium, collagen protein, thioctic acid mixing.
(2), to adding in said mixture appropriate purified water to stir, make mix wetting.
(3), wet stock is mixed.
(4), add EGF, add purified water quantitatively to 100g, mix homogeneously.
(5) mixture, step (4) being obtained is sub-packed in in type bubble-cap with 0.35ml/ unit.
(6), mixture after subpackage is placed in to-70 DEG C and is frozen into solid.
(7), freezing being placed in vacuum freeze carry out sublimation drying, obtains a chip solid in each unit.
(8), use packer heat sealed package.
The cosmetics that this enforcement obtains are also referred to as instant of wrinkle removing skin care.
Embodiment 9
A kind of crease-resistant, the whitening freeze-dried instant cosmetics of method preparation that provide according to embodiment 1, comprise that component is as follows:
PVP-K30，1g；
Mannitol, 1g;
Hyaluronate sodium, 10g;
EGF，0.008g；
VC，5g；
Collagen protein, 0.5g;
Alpha-arbutin, 0g;
D-panthenol, 0g;
Alpha-lipoic acid, 0.3g.
Component and the proportioning of the freeze-dried instant cosmetics that table 1 provides for the embodiment of the present application 1-9 below.
The whitening effect testing result of the freeze-dried instant cosmetics that table 2 provides for embodiment of the present invention 1-9 below.
The anti-wrinkle effect testing result of the freeze-dried instant cosmetics that table 3 provides for embodiment of the present invention 1-9 below.
Component and the proportioning of the freeze-dried instant cosmetics that table 1 embodiment 1-9 provides
The method of detection of skin whitening effect: for the product of each embodiment, select one group totally 30 healthy womens test, 10 age 25-28 years in 30 women, 10 age 30-35 years, 10 age 40-45 years.Choosing 2cm × 2cm region inside above-mentioned women's forearm is tested position.Measure once per weekend with skin chromaticity detector.According to the go down white-skinned face function of the cosmetics that degree evaluation embodiments of the invention provide of skin colourity.
Japan Minolta CD-2600 spectrophotometer: use the colour analysis of pulsed xenon arc light.Adopt Lab color system, collect the reflected light vertical with skin surface, its measurement parameter is as follows: the brightness of L reflection color, from white to black change color scope (change in value scope: 100 white～0 black); A reflects the change color scope (change in value scope :+60 redness～-60 green) from red to green; B reflection is (value excursion :+60 yellow～-60 blueness) from Huang to blue change color scope, is proportionate with the black pigment of skin content, and this and melanin reflect yellow have relation.
Utilize Japanese Minolta CD-2600 spectrophotometer to measure respectively the b value at the tested position of 30 female skins, and get the meansigma methods of 30 people's b value, be recorded in table 2 below.The lower expression skin of b value is whiter, and the b value before use deducts and uses the difference of the b value after 3 weeks to be designated as Δ b, and the numerical value of Δ b is higher, represents that the whitening effect of cosmetics is better.
The whitening effect testing result (every group of 30 people's average b values) of the freeze-dried instant cosmetics that table 2 embodiment 1-9 provides
| Average b value | Before use | Use after 1 week | Use after 2 weeks | Use after 3 weeks | Δb |
| Embodiment 1 | 18.9 | 18.8 | 18.8 | 18.7 | 0.2 |
| Embodiment 2 | 18.6 | 18.5 | 18.5 | 18.2 | 0.4 |
| Embodiment 3 | 19.2 | 19.2 | 19.0 | 18.8 | 0.4 |
| Embodiment 4 | 18.8 | 18.7 | 18.5 | 18.2 | 0.6 |
| Embodiment 5 | 17.9 | 17.7 | 17.5 | 17.3 | 0.6 |
| Embodiment 6 | 19.3 | 19.1 | 18.9 | 18.7 | 0.6 |
| Embodiment 7 | 18.9 | 18.7 | 18.4 | 17.9 | 1.0 |
| Embodiment 8 | 18.6 | 18.5 | 18.5 | 18.5 | 0.1 |
| Embodiment 9 | 18.7 | 18.6 | 18.5 | 18.3 | 0.4 |
Brief description anti-wrinkle effect detection method and instrument.
Method: talysurf method, refers to use talysurf to measure the method for wrinkle copy surface roughness.Its ultimate principle is particulate metal needle device that application has surface scan probe, the relevant parameter of mechanical measurement skin surface copy.Because single sweep operation only provides linear one-dimensional data, if desired acquisition two dimension, three-dimensional data need Multiple-Scan, each sweep spacing approximately 1 minute.
Adopt wrinkle grade scale below.
0 grade: the degree of depth of wrinkle is less than 49 μ m;
I level: 2 or 3 shallow wrinkles, wrinkle depth scope is 50-100 μ m, length L EssT.LTssT.LT1.5cm;
II level: 4 to 6 shallow wrinkles, wrinkle depth scope is 0.2-0.5mm, length L EssT.LTssT.LT2cm;
III level: several are compared with deep wrinkle, and wrinkle depth scope is 0.6-1mm, and length reaches 3cm, accompany shallow wrinkle simultaneously.
For the product of each embodiment, select one group totally 30,40-45 age, healthy women year is tested, and choosing forehead region is tested position, the front front of eye-level.30 women's forehead skins of overall merit in rank, residing the skin that exceedes 20 women rank is inserted to table 3, test result is as shown in table 3.
The anti-wrinkle effect testing result of the freeze-dried instant cosmetics that table 3 embodiment 1-9 provides
| ? | Before use | Use after 1 week | Use after 2 weeks | Use after 3 weeks |
| Embodiment 1 | III level | III level | III level | III level |
| Embodiment 2 | III level | III level | II level | II level |
| Embodiment 3 | III level | III level | III level | II level |
| Embodiment 4 | III level | III level | II level | II level |
| Embodiment 5 | III level | III level | II level | II level |
| Embodiment 6 | III level | III level | II level | II level |
| Embodiment 7 | III level | III level | III level | III level |
| Embodiment 8 | III level | III level | II level | I level |
| Embodiment 9 | III level | III level | II level | II level |
Test result by above-described embodiment can draw, the raw material content with whitening anti-wrinkling function in monolithic tablet is high, and not necessarily causes whitening or crease-resistant effective.The synergy of this and each raw material, and the absorbability of skin is relevant.Character crease-resistant, whitening freeze-dried instant cosmetics provided by the invention is stable, and effect crease-resistant and whitening is better.The whitening effect of the cosmetics that especially, the embodiment of the present invention 7 provides is especially good.The anti-wrinkle effect of the cosmetics that the embodiment of the present invention 8 provides is especially good.And the cost of embodiment 7 and 8 prepared cosmetics is lower.Have under the prerequisite of identical whitening or anti-wrinkle effect, the cosmetics that yes cost is lower are better.
The above, be only preferred embodiment of the present invention, is not intended to limit protection scope of the present invention.Every equalization that content is done according to the present invention changes and modifies, and is all encompassed in the scope of the claims of the present invention.
Claims (10)
1. crease-resistant, whitening freeze-dried instant cosmetics, comprise following component:
Excipient, 2-16 weight portion;
Hyaluronate sodium, 0.1-10 weight portion;
EGF, 0.0002～0.008 weight portion;
VC, 0～5 weight portion;
Collagen protein, 0～0.5 weight portion;
Alpha-arbutin, 0～3 weight portion;
D-panthenol, 0～0.5 weight portion;
Alpha-lipoic acid, 0～0.3 weight portion.
2. crease-resistant, whitening freeze-dried instant cosmetics according to claim 1, is characterized in that, described cosmetics comprise following component:
Excipient, 7-16 weight portion;
Hyaluronate sodium, 0.2-2 weight portion;
EGF, 0.001～0.008 weight portion;
VC, 2.5～5 weight portions;
Collagen protein, 0.2～0.5 weight portion;
Alpha-arbutin, 0.3～3 weight portion;
D-panthenol, 0.5 weight portion;
Alpha-lipoic acid, 0.3 weight portion.
3. crease-resistant, whitening freeze-dried instant cosmetics according to claim 1, is characterized in that, described cosmetics comprise following component:
Excipient, 7 weight portions;
Hyaluronate sodium, 0.5 weight portion;
EGF, 0.001 weight portion;
VC, 2.5 weight portions;
Collagen protein, 0.2 weight portion;
Alpha-arbutin, 0.3 weight portion;
D-panthenol, 0.5 weight portion;
Alpha-lipoic acid, 0.3 weight portion.
4. crease-resistant, whitening freeze-dried instant cosmetics according to claim 1, is characterized in that, described cosmetics are made up of following component:
Excipient, 2-16 weight portion;
Hyaluronate sodium, 0.1-10 weight portion;
EGF, 0.0002～0.008 weight portion;
VC, 0～5 weight portion;
Collagen protein, 0～0.5 weight portion;
Alpha-arbutin, 0～3 weight portion;
D-panthenol, 0～0.5 weight portion;
Alpha-lipoic acid, 0～0.3 weight portion.
5. crease-resistant, whitening freeze-dried instant cosmetics according to claim 1, is characterized in that, described cosmetics are made up of following component:
Excipient is 7 weight portions, and VC is 2.5 weight portions, and hyaluronate sodium is 0.5 weight portion, and alpha-arbutin is 0.3 weight portion, and D-panthenol is 0.5 weight portion, and EGF is 0.0004 weight portion.
6. crease-resistant, whitening freeze-dried instant cosmetics according to claim 1, is characterized in that, described cosmetics are made up of following component:
Excipient is 7 weight portions, and hyaluronate sodium is 0.5 weight portion, and the content of collagen protein is 0.2 weight portion, and the content of alpha-lipoic acid is 0.3 weight portion, and EGF is 0.001 weight portion.
7. a preparation method of preparing crease-resistant, the whitening freeze-dried instant cosmetics as described in one of claim 1 to 6, is characterized in that, described method comprises the steps:
(1) the solid-state raw material, taking except EGF mixes;
(2), to adding in said mixture appropriate purified water to stir, make mix wetting;
(3), wet stock is mixed;
(4), add EGF and other liquid material, add purified water quantitatively to 100 weight portions, mix homogeneously; (5) mixture, step 4 being obtained is sub-packed in in type bubble-cap with 0.1ml-1ml/ unit;
(6), mixture after subpackage is placed in to subzero 40 DEG C to subzero 80 DEG C and is frozen into solid;
(7), freezing being placed on carried out sublimation drying in vacuum freeze;
(8), use packer heat sealed package.
8. the preparation method of crease-resistant, whitening freeze-dried instant cosmetics according to claim 7, is characterized in that, in described step (5), mixture is sub-packed in in type bubble-cap with 0.35ml/ unit.
9. a preparation method of preparing crease-resistant, whitening freeze-dried instant cosmetics as claimed in claim 5, is characterized in that, described method comprises the steps:
(1), take excipient, VC, hyaluronate sodium, alpha-arbutin mixing;
(2), to adding in said mixture appropriate purified water to stir, make mix wetting;
(3), wet stock is mixed;
(4), add D-panthenol, EGF, then add purified water quantitatively to 100 weight portions, mix homogeneously;
(5) mixture, step 4 being obtained is sub-packed in in type bubble-cap with 0.35ml/ unit;
(6), mixture after subpackage is placed in to-70 DEG C and is frozen into solid;
(7), freezing being placed in vacuum freeze carry out sublimation drying, obtains chip solid;
(8), use packer heat sealed package.
10. a preparation method of preparing crease-resistant, whitening freeze-dried instant cosmetics as claimed in claim 6, is characterized in that, described method comprises the steps:
(1), take excipient, hyaluronate sodium, collagen protein, alpha-lipoic acid mixing;
(2), to adding in said mixture appropriate purified water to stir, make mix wetting;
(3), wet stock is mixed;
(4), add EGF, add quantitatively to 100 of purified water weight portion, mix homogeneously;
(5) mixture, step 4 being obtained is sub-packed in in type bubble-cap with 0.35ml/ unit;
(6), mixture after subpackage is placed in to-70 DEG C and is frozen into solid;
(7), freezing being placed in vacuum freeze carry out sublimation drying, obtains chip solid;
(8), use packer heat sealed package.
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| CN104873443A (en) * | 2015-06-25 | 2015-09-02 | 湖南一九生物科技有限公司 | SOD skin care product and preparation method |
| CN104873443B (en) * | 2015-06-25 | 2017-08-25 | 湖南一九生物科技有限公司 | A kind of SOD skin care item and preparation method |
| CN106309143A (en) * | 2015-07-01 | 2017-01-11 | 上海亮靓生物科技有限公司 | Manufacturing method of nano freeze-dried tablet for cosmetic |
| CN105078783A (en) * | 2015-09-06 | 2015-11-25 | 无锡贝迪生物工程有限公司 | Instant collagen lyophilized ball and preparation method thereof |
| CN106726703A (en) * | 2016-11-17 | 2017-05-31 | 徐慧婷 | A kind of cosmetics based on Transdermal absorption |
| KR20200101202A (en) * | 2019-02-19 | 2020-08-27 | 뷰티풀코리아 주식회사 | Freeze dried cosmetics for skin improvement |
| KR102187653B1 (en) * | 2019-02-19 | 2020-12-07 | 뷰티풀코리아 주식회사 | Freeze dried cosmetics for skin improvement |
| CN109939050A (en) * | 2019-04-12 | 2019-06-28 | 豌豆之本(北京)科技有限公司 | Freeze-dried composition and preparation method thereof for cosmetics |
| CN110236982A (en) * | 2019-07-17 | 2019-09-17 | 上海纳米技术及应用国家工程研究中心有限公司 | Rapidly-soluble preparation method of protein freeze-dried powder for cosmetics and products thereof and application |
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| CN103932911B (en) | 2016-03-30 |
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