CN106619308A - Skin whitening and moisturizing composition - Google Patents
Skin whitening and moisturizing composition Download PDFInfo
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- CN106619308A CN106619308A CN201710007078.XA CN201710007078A CN106619308A CN 106619308 A CN106619308 A CN 106619308A CN 201710007078 A CN201710007078 A CN 201710007078A CN 106619308 A CN106619308 A CN 106619308A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
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- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
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Abstract
The invention discloses a skin whitening and moisturizing composition. The composition is mainly prepared from a scytosiphon extract, a grape seed extract, glycollic acid, lavender essential oil and marine biological complex enzymes. A product of the skin whitening and moisturizing composition is capable of effectively exfoliating, controlling oil-water balance, moisturizing skin and promoting metabolism; by combination of strong scavenging free radicals of scytosiphon and the multifunctional nutritional marine biological complex enzymes, the composition plays a great role in skin whitening and moisturizing; in addition, the composition can be applied to defective skin with whelks, acnes, comedones, coarse pores and the like. Since raw materials of the composition are basically natural products, the composition is mild and free of skin irritation. Skin whitening and moisturizing essence/water is high in perception performance and physicochemical index and high in cold and heat resistance stability.
Description
Technical field
The present invention relates to cosmetic field, and in particular to composition is moistened in a kind of whitening.
Technical background
The colour of skin is strongly dependent on melanic generation, divides a word with a hyphen at the end of a line and be distributed.At present, whitening spot-removing research emphasis are concentrated on
On tyrosinase, tyrosine is a kind of amino acid very common in human body, is also a kind of metal oxidation reduction enzyme of cupric, often
Individual subunit contains 2 metal copper ions, and 2 copper ion decibels are combined with the amino acid in protein molecule.In melanocyte melanocyte
In vivo, tyrosine forms DOPA quinone by DOPA is generated after tyrosinase catalysis after DOPA dehydrogenation, and is rearranged into 5,6 hydroxyls
Indoles, after indoles polymerization melanoprotein is formed in combination with the structural proteins in melanocyte body, melanoprotein namely we generally say
Melanin.The accurate here of skin regulation mechanism has some idea of, melanic generating process, be also in fact oxygen radical from
My reset procedure.
The environmental factors such as ultraviolet also can cause damage to skin, such as the burning of the sun, tanned, sunburn, pigmentation.Cause
The thought traditional attractive in appearance of " a white screening hundred is ugly " so that the pursuit of people's dialogue never stops.And the process of whitening is also in fact skin
The process that skin updates and cleans, and getting rid of aging cuticula can allow skin relatively dry, dry skin easily produces black
Pigment, needs to supplement the nutrients in time and moisture.Moisturizing could also say that any skin quality is required for the basic homework for doing how
It is also topic that whitening intelligents are concerned about to make skin whitening, moisturizing neglect neither.It may be said that skin whitening and skin care are mutually to coordinate
, the premise of whitening is skin care.
Chinese patent application CN103239383A disclose it is a kind of with skin whitening, moisturizing effect Chinese medicine composition, mainly by
Chinese herbaceous peony, lotus flower, purple sesame, almond, motherwort, centella, silk, green bamboo, olive leaf, marine alga, oat, cactus, pearl, when
Return, pawpaw, kuh-seng, garden burnet composition, the Chinese medicine that the invention is adopted is mostly rare medicinal herbs, and complicated component, preparation cost is high.
At present, on the market whitening product is varied, is mostly chemicals, the heavy metal such as how leaded and mercury, although can
Can highlight skin color in the short time, but Long-Time Service can cause irreversible destruction to skin, and water imbibition is poor, moisturizing rate
It is low, and heavy metals exceeding standard, health can be affected.In recent years, the Chinese medicine whitening quite favored, using Chinese medical extract as work
Property composition be added in whitening product, but Chinese medicine raw material select and compatibility relationship it is of crucial importance, compatibility is bad may not to be reached
The effect of skin whitening, moisturizing, can also bring other side effects.
The content of the invention
It is an object of the invention to provide a kind of compatibility science, has no toxic side effect, the effect group with whitening Glycerin
Compound.
The technical solution used in the present invention is as follows：
Composition is moistened in a kind of whitening for providing includes the component of following weight portion：
Preferably, there is provided a kind of whitening moisten the component of composition including following weight portion：
Composition is moistened in a kind of whitening for providing, and the tawny daylily algae extract is prepared by following methods：
(1) spontaneously dry after fresh water is washed down, with pulverizer powdery is worn into, cross 0.5mm screen clothes, 4 DEG C of sealing preserves；
(2) the dried tawny daylily algae powder of 1g is weighed, 100 μ L alkali proteases and 100mL buffer solutions is added, is extracted at 50 DEG C
12h；
(3) leaching liquor is put into centrifuge and 20min (rotating speed 5000r/min) is centrifuged, take supernatant, reduced pressure concentration is cold
It is lyophilized dry；- 20 DEG C are in store for.
Composition is moistened in a kind of whitening for providing, and buffer solution is 0.1mol/L in the step (2), and the sodium carbonate of pH10-
Sodium bicarbonate solution.
Composition is moistened in a kind of whitening for providing, and the grape seed extract is prepared by following methods：
(1) 1 part of grape pip is weighed, by 1:8 solid-liquid ratio, by the grape pip 80% ethanol immersion 30min is immersed；
(2) mixed liquor of step (1) is placed in into heating and refluxing extraction 3h in water-bath, is filtered, collect filtrate, filter residue is with 8 times
Measure 80% ethanol to repeat to extract once, merge filtrate twice；
(3) by the filtrate reduced in volume of step (2) to without alcohol taste, concentrate is adsorbed by AB-8 macroporous resin columns,
First with distillation water elution, then 60% ethanol elution is used, collect 60% ethanol eluate, grape pip extraction is obtained after reduced pressure concentration
Thing.
It is that essence is moistened in whitening that the type of composition is moistened in a kind of whitening for providing.
Effect or feature of main component of the present invention is as follows：
" food and medicine consangunity " property of tawny daylily algae, it is antibacterial with antitumor, treat Thyroid Gland Swell and heat-clearing toxin-expelling functions.Tawny daylily algae
The sodium alginate that extract contains, is made up of the plant polyose such as β D mannuronic acids and α guluronic acids.Modern study shows：
Tawny daylily algae extract is rich in phenolic compound, the scavenging capacity with very strong free radical, to hydroxy radical, the clearance rate of alkyl sum
It is very high and suitable to the clearance rate and ascorbic acid of hydroxy radical and alkyl.Tawny daylily algae also shows good copper ion tolerance
Property, by improving the activity of frond endoperoxide enzyme and suppressing the activity of lipoxygenase, effectively reply copper ion causes
Oxidative pressure.Therefore in the present invention, the abundant plant polyose of tawny daylily algae extract plays anti-aging, radioresistance and antibacterial and makees
With；Phenolic compound, can be anti-oxidant, reaches whitening effect.
Containing catechin and OPC class in grape seed extract, OPC is potent free radical scavenger,
There is this very strong activity in vivo, and it is complete rapidly in people's body absorption.Suppress TYR enzyme living features because having, can will be black
The adjacent benzene diquinone construction recovery of pigment makes melanin fade into phenolic structure.Its whitening effect is vitamin e significantly
50 times, tie up his C 20 times can delaying aging.
Glycolic contains the special construction of hydroxyl and carboxyl, can be with metal cation by being coordinated bond formed Hydrophilic chelate
Thing, therefore the growth to iron-oxidizing bacterium has obvious inhibitory action, can be used as bactericide treatment；It has removal dead skin, promotes
Effect of epidermal renewal.
The complex mixture that Lavender is made up of many different types of aromatic compounds, predominantly fragrant camphor tree
Alcohol, acetic acid linalool, cineole, rosemary, its fragrance can make one to be in a cheerful frame of mind, and affect the change of sympathetic Holy Bible system.Its
In, cineole can be cooked anodyne, and aromatotherapy can mitigate the pain sensation, by improving intracellular loops phosphoric acid glycosides level, relaxing smooth muscle
And generation vasodilator effect；Linalool is Lavender antimicrobial component, can suppress the growth of 17 kinds of bacterium；Its fan contained changes
Fragrant acid can suppress the peroxidating of lipid；Lavender can promote wound healing or reduce scar, meanwhile, can purify, pacify the heart
Spirit, mitigates angry and used-up sensation.
The enzyme that marine organisms complex enzyme is made up of three kinds of different enzymes, a kind of enzyme can only be catalyzed one kind or class chemistry is anti-
Should, and biological internal metabolic process is a series of complicated change procedure, needs various enzymatics.Nucleic acid, protease, collagen
The enzymes such as enzyme, carrageenase, alginase, may act on cell, and the impaired telomere of activation Telomerase reparation recovers cell young.
The device have the advantages that as follows：(1) Lavender cleaning skin, controls water and oil balance；Glycolic
Exfoliating Scrub；Grape seed extract inhibitory enzyme activity, skin care；The powerful removing free radical of tawny daylily algae；In conjunction with multi-functional, Fu Ying
Foster marine organisms complex enzyme, together, composition can preferably play its whitening effect to this several material combination；(2) second
Alkyd, all contains antipathogenic composition in tawny daylily algae extract and Lavender, wherein Lavender has clearing heat and detoxicating, can promote
The skin-protecting functions such as damaged tissues regeneration recovery, can quickly enter the bacterial eradication of lower 240 microns of skin, and bacterium under skin is grown
The raw, whelk that hair follicle blocking is caused, acne, blackhead, pore is thick has certain effect, while being formed in skin skin corium
Gold diaphragm, resists bacterium and grows again.So the practicality of the composition of the present invention is wide, it is adapted to any skin quality；(3) tawny daylily algae
Extract, grape seed extract is easily obtained, and with reference to other several raw materials, adds the base-material of preparing cosmetics elite/water, this
Bright to be easy to industrialized production, market value is high, it is easy to popularization and application；(4) molecular weight of glycolic is very little, and it can be effectively
Skin permeation pore；The how infringement of static free radical many cells film more than Portugal in grape pip, adjusts the permeability of capillary；Smoke
The affinity interaction of clothing grass essential oil enters subcutaneous skin care；Marine organisms complex enzyme can provide nutrition to skin, promote metabolism, this
The combination of several compositions, serves synergistic function, and the raw material for reaching effect (5) selection of whitening skin care is essentially day
So product, gently non-stimulated to skin, and elite/water is moistened in the whitening of the present invention, and organoleptic properties and physical and chemical index are high, resist cold resistance to
Heat endurance is good.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
The embodiment of the present invention 1～4 and the whitening of comparative example 1～2 are moistened essence formula and are shown in Table one
Table one
The tawny daylily algae extract is prepared by following methods：
(1) spontaneously dry after fresh water is washed down, with pulverizer powdery is worn into, cross 0.5mm screen clothes, 4 DEG C of sealing preserves；
(2) the dried tawny daylily algae powder of 1g is weighed, 100 μ L alkali proteases and 100mL buffer solutions is added, is extracted at 50 DEG C
12h；
(3) leaching liquor is put into centrifuge and 20min (rotating speed 5000r/min) is centrifuged, take supernatant, reduced pressure concentration is cold
It is lyophilized dry；- 20 DEG C are in store for.
The buffer solution be 0.1mol/L, the soda-sodium bicarbonate solution of pH10.
The grape seed extract is prepared by following methods：
(1) 1 part of grape pip is weighed, by 1:8 solid-liquid ratio, by the grape pip 80% ethanol immersion 30min is immersed；
(2) mixed liquor of step (1) is placed in into heating and refluxing extraction 3h in water-bath, is filtered, collect filtrate, filter residue is with 8 times
Measure 80% ethanol to repeat to extract once, merge filtrate twice；
(3) by the filtrate reduced in volume of step (2) to without alcohol taste, concentrate is adsorbed by AB-8 macroporous resin columns,
First with distillation water elution, then 60% ethanol elution is used, collect 60% ethanol eluate, grape pip extraction is obtained after reduced pressure concentration
Thing.
Efficacy validation
Experimental subjects：30 to 45 years old aspiration triers 140 are selected to be randomly divided into three groups, embodiment 1～4, comparative example 1～5
Per group of 20 people, comparative example 5 is certain outstanding commercially available whitening nourishing essence element of whitening nourishes effect.
Test method：All volunteers carry out face cleaning process before sleeping every night, and everyone left face, left hand use U.S. of place group
White nourishing essence element, right face, the right hand are not used；On probation one month by a definite date, at the 7th day, the 15th day, each statistics was once tried within the 30th day
With result.Effectively be expressed as trier right-hand man contrast hand it is more delicate, without dead skin, left face skin of face is whiter, blackhead sparrow
Spot is significantly reduced；Invalid representation is not any change for trier's skin texture；Generally but trier's skin quality makes moderate progress effect
Fruit is notable, between effective and invalid.
Using embodiment 1～4, there is not bad reaction, the trouble of correspondence embodiment 1～4 in comparative example 1～5, patient
Person, very well, use is very comfortable non-stimulated for reaction effect, and essence is easy to preserve, and all patients complete experiment.
Experimental result see the table below 3
The whitening nourishing essence of embodiment 1～4 element items effect can be obtained by table three of the invention obviously higher than comparative example 1～5
Whitening nourishing essence element have become apparent from more preferable whitening, bright color, skin care, Exfoliating Scrub, effect of acne-removing inflammation-diminishing.It is right
Ratio 3 and comparative example 4 and embodiment 1 are distinguished as not adding tawny daylily algae extract and do not add grape seed extract, by comparative example 3
It is visible in whitening nourishing essence of the present invention element with the whitening of comparative example 1, skin care, acne-removing inflammation-diminishing, Exfoliating Scrub efficiently individual quantity
Tawny daylily algae extract and grape seed extract have the effect of Synergistic.
Above example only illustrates embodiment of the present invention, does not there is any pro forma restriction to the present invention；Appoint
What is engaged in professional and technical personnel, all has the ability to make some changes using the technology contents for disclosing or modifies, and becomes equivalent
The Equivalent embodiments of change, according to the technology of the present invention essence, simply modification, equivalent variations and modification are carried out to the present invention, are belonged to
In the range of technical solution of the present invention.
Claims (6)
1. composition is moistened in a kind of whitening, it is characterised in that composition is moistened in the whitening includes the component of following weight portion：
2. composition is moistened in a kind of whitening according to claim 1, it is characterised in that composition is moistened in the whitening to be included
The component of following weight portion：
3. composition is moistened in a kind of whitening according to claim 1, it is characterised in that the tawny daylily algae extract is by with lower section
It is prepared by method：
(1) spontaneously dry after fresh water is washed down, with pulverizer powdery is worn into, cross 0.5mm screen clothes, 4 DEG C of sealing preserves；
(2) the dried tawny daylily algae powder of 1g is weighed, 100 μ L alkali proteases and 100mL buffer solutions is added, at 50 DEG C 12h is extracted；
(3) leaching liquor is put into centrifuge and 20min (rotating speed 5000r/min) is centrifuged, take supernatant, reduced pressure concentration, freezing is dry
It is dry；- 20 DEG C are in store for.
4. composition is moistened in a kind of whitening according to claim 3, it is characterised in that buffer solution is in the step (2)
The soda-sodium bicarbonate solution of 0.1mol/L, pH10.
5. composition is moistened in a kind of whitening according to claim 1, it is characterised in that the grape seed extract is by following
It is prepared by method：
(1) 1 part of grape pip is weighed, by 1:8 solid-liquid ratio, by the grape pip 80% ethanol immersion 30min is immersed；
(2) mixed liquor of step (1) is placed in into heating and refluxing extraction 3h in water-bath, is filtered, collect filtrate, filter residue is measured with 8 times
80% ethanol repeats to extract once, merges filtrate twice；
(3) by the filtrate reduced in volume of step (2) to without alcohol taste, concentrate is adsorbed by AB-8 macroporous resin columns, is first used
Distillation water elution, then 60% ethanol elution is used, 60% ethanol eluate is collected, grape seed extract is obtained after reduced pressure concentration.
6. composition is moistened in a kind of whitening according to any one of claim 1-5, it is characterised in that group is moistened in the whitening
The type of compound is that elite/water is moistened in whitening.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710007078.XA CN106619308A (en) | 2017-01-04 | 2017-01-04 | Skin whitening and moisturizing composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710007078.XA CN106619308A (en) | 2017-01-04 | 2017-01-04 | Skin whitening and moisturizing composition |
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| CN106619308A true CN106619308A (en) | 2017-05-10 |
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| CN201710007078.XA Pending CN106619308A (en) | 2017-01-04 | 2017-01-04 | Skin whitening and moisturizing composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740756A (en) * | 2018-04-28 | 2018-11-06 | 广东日可威富硒食品有限公司 | A kind of anti-fatigue anti-senility seaweed face |
| CN111617020A (en) * | 2020-07-02 | 2020-09-04 | 石保国 | Beauty dressing composition based on marine organisms and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349867A (en) * | 2011-11-02 | 2012-02-15 | 广州舒泰生物技术有限公司 | Water-replenishing repairing cosmetic as well as preparation method and application thereof |
| CN104224602A (en) * | 2013-06-23 | 2014-12-24 | 青岛道合生物科技有限公司 | Antioxidant facial mask |
-
2017
- 2017-01-04 CN CN201710007078.XA patent/CN106619308A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349867A (en) * | 2011-11-02 | 2012-02-15 | 广州舒泰生物技术有限公司 | Water-replenishing repairing cosmetic as well as preparation method and application thereof |
| CN104224602A (en) * | 2013-06-23 | 2014-12-24 | 青岛道合生物科技有限公司 | Antioxidant facial mask |
Non-Patent Citations (2)
| Title |
|---|
| 徐小娟: "萱藻（Scytosiphon lomentaria）的化学成分及其生物活性研究", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑（月刊 ）》 * |
| 高婷: "葡多酚的提取、纯化工艺及抗氧化性研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑（月刊 ）2014年第 05 期》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740756A (en) * | 2018-04-28 | 2018-11-06 | 广东日可威富硒食品有限公司 | A kind of anti-fatigue anti-senility seaweed face |
| CN111617020A (en) * | 2020-07-02 | 2020-09-04 | 石保国 | Beauty dressing composition based on marine organisms and preparation method thereof |
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Application publication date: 20170510 |