CN105125419A - Mask with vitamin E liposome modified by polyethylene glycol and preparing method of mask - Google Patents
Mask with vitamin E liposome modified by polyethylene glycol and preparing method of mask Download PDFInfo
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- CN105125419A CN105125419A CN201510646507.9A CN201510646507A CN105125419A CN 105125419 A CN105125419 A CN 105125419A CN 201510646507 A CN201510646507 A CN 201510646507A CN 105125419 A CN105125419 A CN 105125419A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The invention belongs to the technical field of daily care products, and discloses a mask with vitamin E liposome modified by polyethylene glycol and a preparing method of the mask. A matrix layer is formed by the vitamin E liposome modified by polyethylene glycol on backing shell fabric, then a humectant is added, and the backing shell fabric is fixed by lining shell fabric and cut to obtain the mask. The vitamin E liposome modified by polyethylene glycol is prepared from, by weight, 10-100 parts of lecithin, 10-100 parts of cholesterol, 10-150 parts of vitamin E, 200-600 parts of sodium cholate, 400-4000 parts of polyethylene glycol and 400-800 parts of freeze-dried protective agents. The vitamin E liposome modified by polyethylene glycol is adopted as an effective component, so that the vitamin E stably exists in the skin layer easily and is efficiently released for human body skin to absorb, and the mask has good wrinkle removal and skin care effects.
Description
Technical field
The invention belongs to daily nursing product technical field, be specifically related to a kind of polyethyleneglycol modified vitamin E liposome facial film and preparation method thereof.
Background technology
Along with the quickening of Urbanization Construction, air pollution is more and more serious, and life stress is also increasing, the generation of people's oxygen-derived free radicals in life every day and gather more and more serious, and cause skin ageing phenomenon to increase the weight of, the probability that dermatosis occurs is also increasing.Develop a good skin-protection product, effectively can reduce costs and oxygen-derived free radicals can be eliminated efficiently.
Vitamin E has good cosmetic result.First, the pendant double bonds of vitamin E can participate in the oxidation-reduction process of sulfydryl directly, suppresses the activity of TYR enzyme, prevents pigmentation.Vitamin E also has expansion peripheral vessel, improves blood vessel microcirculation, promotes the conveying of nutritional labeling and the effect of internal metabolism rubbish excretion.In addition, vitamin E can make it from the oxidative damage of free radical by Cell protection film, so can help the natural protective barrier repairing and consolidate skin, pins the moisture of skin, provides nourishing from inside to outside.
But existing commercially skin care item have ignored the chemical composition of these cheapnesss such as vitamin E often, and go to pursue and add some and be difficult to extract but effect and vitamin E material very nearly the same, such as SOD (superoxide dismutase).SOD is a kind of enzyme be present in people or other biological body, damaged cell can be repaired, scavenging activated oxygen, but its extraction is quite difficult, cost intensive, so higher containing the skin care item price general charged of SOD, and the content of in fact SOD can not be very high, and therefore its skin effect is also restricted; And vitamin E is a kind of chemical composition of extensive existence, antiageing effect is good, the most important thing is to extract easily, and cost is cheap, is applicable to large-scale production and commercialization.Secondly, a lot of skin care item are all for moisturizing at present, and as contained glycerol, containing hyaluronic skin care item, but they can not produce effective protection to ultraviolet invasion and attack.
In addition, still there are some problems in existing vitamin E product: adopt phospholipid directly to encapsulate vitamin E and other skin care ingredients; The O/W microemulsion parcel vitamin E formed with glycerol and surfactant, distilled water; Diameter of particle containing vitamin E is larger.Relevant patent is as " skin care item of resisting age of skin " (CN1345225), " complex capsule of vitamin E " (CN101040933), and " a kind of vitamin E cream and compound method thereof " (CN101011326).The above two are intended to illustrate that the liposome encapsulation adopting above-mentioned way to prepare is lower, and stability is poor, is traditional method for preparing lipidosome.Poor stability is that surface of liposome is with electric charge, and this feature easily makes liposome be identified as allogenic material by the macrophage in blood and be engulfed; CN101011326 is intended to illustrate that size can affect liposome and be absorbed by the skin through skin, and particle diameter is less, easier through skin, and effect of generation is also more obvious.
Therefore, develop a envelop rate high, the skin care item containing vitamin E flexible lipidosome that percutaneous permeation is strong, not only can reduce skin protection cost, also significantly improve skin effect, there is important economic benefit and social benefit.
Summary of the invention
In order to solve the shortcoming and defect part of above prior art, primary and foremost purpose of the present invention is to provide a kind of polyethyleneglycol modified vitamin E liposome facial film.
Another object of the present invention is to the preparation method that above-mentioned polyethyleneglycol modified vitamin E liposome facial film is provided.
The object of the invention is achieved through the following technical solutions:
A polyethyleneglycol modified vitamin E liposome facial film, described facial film on backing fabric, forms hypothallus with polyethyleneglycol modified vitamin E liposome, then adds wetting agent, and fixed by liner fabric, obtain through cutting; Described polyethyleneglycol modified vitamin E liposome is made up of the component of following weight portion: 10-100 part lecithin, 10-100 part cholesterol, 10-150 part vitamin E, 200-600 part cholic acid are received, 400-4000 part Polyethylene Glycol and 400-800 part freezing drying protective agent.
The preferred normal saline of described wetting agent.
Described backing fabric and liner fabric are preferably hydrophilic non-woven, silk fabric or gauze.
Described lecithin is selected from least one in soybean lecithin, hydrogenated soy phosphatidyl choline, Ovum Gallus domesticus Flavus lecithin, dipalmitoyl phosphatidyl choline, two Semen Myristicae phosphatidylcholines, DLPC and synthetic phospholipid.
At least one in described freezing drying protective agent preferably glycerine, lactose, sucrose, mannitol, glucose and trehalose.
The particle size range of described polyethyleneglycol modified vitamin E liposome is 50-200nm, and Zeta potential is-30 ~-55mV, and envelop rate is 70%-90%.
The preparation method of above-mentioned polyethyleneglycol modified vitamin E liposome facial film, comprises following preparation process:
(1) take lecithin, cholesterol, vitamin E and sodium cholate and be placed in container, add the mixed solvent of chloroform and methanol, stirring and dissolving evenly obtains mixed solution;
(2) mixed solution is placed in Rotary Evaporators, at the temperature of 40-80 DEG C, vacuum extracts solvent, obtains the liposome membrane being attached to wall;
(3) Polyethylene Glycol PBS buffer solution is dissolved, preparation mass concentration is the polyglycol solution of 1%-20%, then join in the Rotary Evaporators of step (2), under temperature is 40-80 DEG C of condition, rotates aquation, obtains liposome turbid liquor;
(4) by the liposome turbid liquor ultrasonic disperse of step (3), being then placed in molecular cut off is that the bag filter of 8000-14000 is dialysed, the vitamin E that removing is free;
(5) in the system of step (4), add freezing drying protective agent, pre-freeze postlyophilization, obtain polyethyleneglycol modified vitamin E liposome powder;
(6) liposome powder uniform application step (5) obtained, on backing fabric, forms one deck hypothallus, and adds wetting agent and carry out moisturizing;
(7) the backing fabric one deck liner fabric containing liposome matrix layer step (6) obtained is fixed, and cutting obtains a kind of polyethyleneglycol modified vitamin E liposome facial film.
Preferably, the mixed solvent of the chloroform described in step (1) and methanol refers to that the volume ratio of chloroform and methanol is the mixed solvent of 1:1.
Preferably, the pre-freeze described in step (5) refers to and is-50 to-100 DEG C of pre-freezes more than 12 hours.
Preparation method of the present invention and the product tool obtained have the following advantages and beneficial effect:
(1) facial film of the present invention adopts polyethyleneglycol modified vitamin E liposome as effective ingredient, is conducive to vitamin E and is stably present in skin layer and discharges efficiently for human body skin absorption, thus reach good content effect;
(2) by preparation method gained vitamin E liposome particle diameter of the present invention at 50-200nm, the absolute value of surface charge reaches 30mV to 55mV, can ensure wrap up vitamin E component have better stability; Meanwhile, adopt polyethyleneglycol modified liposome, increased substantially the stability of liposome, and then improve envelop rate, gained facial film result of use is better.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited thereto.
Embodiment 1
A preparation method for polyethyleneglycol modified vitamin E liposome facial film, comprises following preparation process:
(1) take Ovum Gallus domesticus Flavus lecithin 0.08g, cholesterol 0.08g, vitamin E 0.04g and sodium cholate 0.2g and be placed in conical flask, adding 20ml volume ratio is the chloroform of 1:1 and the mixed solvent of methanol, and stirring and dissolving evenly obtains mixed solution;
(2) mixed solution is placed in Rotary Evaporators, in the water bath with thermostatic control of 42 DEG C, rotatory vacuum extracts solvent, obtains the liposome membrane being attached to wall;
(3) phosphate buffer of 0.4g Polyethylene Glycol pH7.4 is dissolved, preparation mass concentration is the polyglycol solution of 1%, then join in the Rotary Evaporators of step (2), under 40 DEG C of water bath condition, rotate aquation 1 hour, obtain orange liposome turbid liquor;
(4) by the liposome turbid liquor ultrasonic disperse 5min of step (3), be then placed in molecular cut off be 8000 bag filter dialyse, the vitamin E that removing is free;
(5) in the system of step (4), add 0.8g mannitol, within 16 hours, be placed on lyophilization in freezer dryer-50 DEG C of pre-freezes, obtain polyethyleneglycol modified vitamin E liposome powder;
(6) liposome powder uniform application step (5) obtained, on backing fabric, forms one deck hypothallus, and adds normal saline and carry out moisturizing;
(7) the backing fabric one deck liner fabric containing liposome matrix layer step (6) obtained is fixed, and cutting obtains a kind of polyethyleneglycol modified vitamin E liposome facial film.
The mean diameter of the vitamin E liposome of the present embodiment is 150nm, and Zeta potential is-49.5mV.
The envelop rate of the vitamin E liposome of the present embodiment detects: the orange liposome turbid liquor getting step (3), with the filter of 0.22 μm, bulky grain is filtered, then high speed centrifuge is used, under 15000rpm condition centrifugal 45 minutes, get 1.5mL centrifuge tube clear liquid, be placed in cuvette the absorbance surveying 291.0nm place, survey the full liquid absorbance of this proportioning simultaneously again.The envelop rate being calculated the vitamin E liposome of the present embodiment by absorbance is 79.82%.
Embodiment 2
A preparation method for polyethyleneglycol modified vitamin E liposome facial film, comprises following preparation process:
(1) take Ovum Gallus domesticus Flavus lecithin 0.08g, cholesterol 0.08g, vitamin E 0.04g and sodium cholate 0.3g and be placed in conical flask, adding 20ml volume ratio is the chloroform of 1:1 and the mixed solvent of methanol, and stirring and dissolving evenly obtains mixed solution;
(2) mixed solution is placed in Rotary Evaporators, in the water bath with thermostatic control of 42 DEG C, rotatory vacuum extracts solvent, obtains the liposome membrane being attached to wall;
(3) phosphate buffer of 0.4g Polyethylene Glycol pH7.4 is dissolved, preparation mass concentration is the polyglycol solution of 1%, then join in the Rotary Evaporators of step (2), under 40 DEG C of water bath condition, rotate aquation 1 hour, obtain orange liposome turbid liquor;
(4) by the liposome turbid liquor ultrasonic disperse 5min of step (3), be then placed in molecular cut off be 8000 bag filter dialyse, the vitamin E that removing is free;
(5) in the system of step (4), add 0.4g mannitol, within 16 hours, be placed on lyophilization in freezer dryer-50 DEG C of pre-freezes, obtain polyethyleneglycol modified vitamin E liposome powder;
(6) liposome powder uniform application step (5) obtained, on backing fabric, forms one deck hypothallus, and adds normal saline and carry out moisturizing;
(7) the backing fabric one deck liner fabric containing liposome matrix layer step (6) obtained is fixed, and cutting obtains a kind of polyethyleneglycol modified vitamin E liposome facial film.
The mean diameter of the vitamin E liposome of the present embodiment is 130nm, and Zeta potential is-45.2mV.
The envelop rate of the vitamin E liposome of the present embodiment detects: the orange liposome turbid liquor getting step (3), with the filter of 0.22 μm, bulky grain is filtered, then high speed centrifuge is used, under 15000rpm condition centrifugal 45 minutes, get 1.5mL centrifuge tube clear liquid, be placed in cuvette the absorbance surveying 291.0nm place, survey the full liquid absorbance of this proportioning simultaneously again.The envelop rate being calculated the vitamin E liposome of the present embodiment by absorbance is 70.34%.
Embodiment 3
A preparation method for polyethyleneglycol modified vitamin E liposome facial film, comprises following preparation process:
(1) take Ovum Gallus domesticus Flavus lecithin 0.08g, cholesterol 0.08g, vitamin E 0.03g and sodium cholate 0.4g and be placed in conical flask, adding 20ml volume ratio is the chloroform of 1:1 and the mixed solvent of methanol, and stirring and dissolving evenly obtains mixed solution;
(2) mixed solution is placed in Rotary Evaporators, in the water bath with thermostatic control of 42 DEG C, rotatory vacuum extracts solvent, obtains the liposome membrane being attached to wall;
(3) phosphate buffer of 0.4g Polyethylene Glycol pH7.4 is dissolved, preparation mass concentration is the polyglycol solution of 1%, then join in the Rotary Evaporators of step (2), under 40 DEG C of water bath condition, rotate aquation 1 hour, obtain orange liposome turbid liquor;
(4) by the liposome turbid liquor ultrasonic disperse 5min of step (3), be then placed in molecular cut off be 8000 bag filter dialyse, the vitamin E that removing is free;
(5) in the system of step (4), add 0.6g mannitol, within 16 hours, be placed on lyophilization in freezer dryer-50 DEG C of pre-freezes, obtain polyethyleneglycol modified vitamin E liposome powder;
(6) liposome powder uniform application step (5) obtained, on backing fabric, forms one deck hypothallus, and adds normal saline and carry out moisturizing;
(7) the backing fabric one deck liner fabric containing liposome matrix layer step (6) obtained is fixed, and cutting obtains a kind of polyethyleneglycol modified vitamin E liposome facial film.
The mean diameter of the vitamin E liposome of the present embodiment is 120nm, and Zeta potential is-40.6mV.
The envelop rate of the vitamin E liposome of the present embodiment detects: the orange liposome turbid liquor getting step (3), with the filter of 0.22 μm, bulky grain is filtered, then high speed centrifuge is used, under 15000rpm condition centrifugal 45 minutes, get 1.5mL centrifuge tube clear liquid, be placed in cuvette the absorbance surveying 291.0nm place, survey the full liquid absorbance of this proportioning simultaneously again.The envelop rate being calculated the vitamin E liposome of the present embodiment by absorbance is 78.72%.
Embodiment 4
A preparation method for polyethyleneglycol modified vitamin E liposome facial film, comprises following preparation process:
(1) take Ovum Gallus domesticus Flavus lecithin 0.10g, cholesterol 0.10g, vitamin E 0.15g and sodium cholate 0.6g and be placed in conical flask, adding 20ml volume ratio is the chloroform of 1:1 and the mixed solvent of methanol, and stirring and dissolving evenly obtains mixed solution;
(2) mixed solution is placed in Rotary Evaporators, in the water bath with thermostatic control of 42 DEG C, rotatory vacuum extracts solvent, obtains the liposome membrane being attached to wall;
(3) phosphate buffer of 4g Polyethylene Glycol pH7.4 is dissolved, preparation mass concentration is the polyglycol solution of 1%, then join in the Rotary Evaporators of step (2), under 40 DEG C of water bath condition, rotate aquation 1 hour, obtain orange liposome turbid liquor;
(4) by the liposome turbid liquor ultrasonic disperse 5min of step (3), be then placed in molecular cut off be 8000 bag filter dialyse, the vitamin E that removing is free;
(5) in the system of step (4), add 0.8g mannitol, within 16 hours, be placed on lyophilization in freezer dryer-50 DEG C of pre-freezes, obtain polyethyleneglycol modified vitamin E liposome powder;
(6) liposome powder uniform application step (5) obtained, on backing fabric, forms one deck hypothallus, and adds normal saline and carry out moisturizing;
(7) the backing fabric one deck liner fabric containing liposome matrix layer step (6) obtained is fixed, and cutting obtains a kind of polyethyleneglycol modified vitamin E liposome facial film.
The mean diameter of the vitamin E liposome of the present embodiment is 180nm, and Zeta potential is-33.1mV.The envelop rate of the vitamin E liposome of the present embodiment detects: the orange liposome turbid liquor getting step (3), with the filter of 0.22 μm, bulky grain is filtered, then high speed centrifuge is used, under 15000rpm condition centrifugal 45 minutes, get 1.5mL centrifuge tube clear liquid, be placed in cuvette the absorbance surveying 291.0nm place, survey the full liquid absorbance of this proportioning simultaneously again.The envelop rate being calculated the vitamin E liposome of the present embodiment by absorbance is 80.15%.
Polyethyleneglycol modified vitamin E liposome facial film result of use test of the present invention:
The polyethyleneglycol modified vitamin E liposome facial film of Example 1 is tried out through 30 people, and in one month, result of use table is as follows.Detection mode is user perusal, wherein, all experimenters have no adverse reaction, all moistening effect is indicated except two people, simultaneously polyethyleneglycol modified vitamin E liposome facial film prints effect to the acne removing that has per capita being in adolescence or oily skin for less than 30 years old, there is obvious wrinkle removing effect to more than 40 years old middle age, except individual subject, have certain whitening effect for experimenter in the age whole year.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not restricted to the described embodiments; change, the modification done under other any does not deviate from spirit of the present invention and principle, substitute, combine, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (9)
1. a polyethyleneglycol modified vitamin E liposome facial film, is characterized in that: described facial film on backing fabric, forms hypothallus with polyethyleneglycol modified vitamin E liposome, then adds wetting agent, and fixed by liner fabric, obtain through cutting;
Described polyethyleneglycol modified vitamin E liposome is made up of the component of following weight portion: 10-100 part lecithin, 10-100 part cholesterol, 10-150 part vitamin E, 200-600 part cholic acid are received, 400-4000 part Polyethylene Glycol and 400-800 part freezing drying protective agent.
2. a kind of polyethyleneglycol modified vitamin E liposome facial film according to claim 1, is characterized in that: described wetting agent refers to normal saline.
3. a kind of polyethyleneglycol modified vitamin E liposome facial film according to claim 1, is characterized in that: described backing fabric and liner fabric are hydrophilic non-woven, silk fabric or gauze.
4. a kind of polyethyleneglycol modified vitamin E liposome facial film according to claim 1, is characterized in that: described lecithin is selected from least one in soybean lecithin, hydrogenated soy phosphatidyl choline, Ovum Gallus domesticus Flavus lecithin, dipalmitoyl phosphatidyl choline, two Semen Myristicae phosphatidylcholines, DLPC and synthetic phospholipid.
5. a kind of polyethyleneglycol modified vitamin E liposome facial film according to claim 1, is characterized in that: described freezing drying protective agent refers at least one in glycerol, lactose, sucrose, mannitol, glucose and trehalose.
6. a kind of polyethyleneglycol modified vitamin E liposome facial film according to claim 1, it is characterized in that: the particle size range of described polyethyleneglycol modified vitamin E liposome is 50 ~ 200nm, Zeta potential is-30 ~-55mV, and envelop rate is 70% ~ 90%.
7. the preparation method of a kind of polyethyleneglycol modified vitamin E liposome facial film described in any one of claim 1 ~ 6, is characterized in that comprising following preparation process:
(1) take lecithin, cholesterol, vitamin E and sodium cholate and be placed in container, add the mixed solvent of chloroform and methanol, stirring and dissolving evenly obtains mixed solution;
(2) mixed solution is placed in Rotary Evaporators, at the temperature of 40-80 DEG C, vacuum extracts solvent, obtains the liposome membrane being attached to wall;
(3) Polyethylene Glycol PBS buffer solution is dissolved, preparation mass concentration is the polyglycol solution of 1%-20%, then join in the Rotary Evaporators of step (2), under temperature is 40-80 DEG C of condition, rotates aquation, obtains liposome turbid liquor;
(4) by the liposome turbid liquor ultrasonic disperse of step (3), being then placed in molecular cut off is that the bag filter of 8000-14000 is dialysed, the vitamin E that removing is free;
(5) in the system of step (4), add freezing drying protective agent, pre-freeze postlyophilization, obtain polyethyleneglycol modified vitamin E liposome powder;
(6) liposome powder uniform application step (5) obtained, on backing fabric, forms one deck hypothallus, and adds wetting agent and carry out moisturizing;
(7) the backing fabric one deck liner fabric containing liposome matrix layer step (6) obtained is fixed, and cutting obtains a kind of polyethyleneglycol modified vitamin E liposome facial film.
8. the preparation method of a kind of polyethyleneglycol modified vitamin E liposome facial film according to claim 7, is characterized in that: the mixed solvent of the chloroform described in step (1) and methanol refers to that the volume ratio of chloroform and methanol is the mixed solvent of 1:1.
9. the preparation method of a kind of polyethyleneglycol modified vitamin E liposome facial film according to claim 7, is characterized in that: the pre-freeze described in step (5) refers to and is-50 to-100 DEG C of pre-freezes more than 12 hours.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105943488A (en) * | 2016-06-30 | 2016-09-21 | 安徽天萝生物科技有限公司 | Loofah skincare mask and preparation method thereof |
| CN110859798A (en) * | 2019-10-31 | 2020-03-06 | 广州浚远康生物科技有限公司 | Anti-aging repairing mask liquid containing human umbilical cord mesenchymal stem cell secretion and preparation method thereof |
| CN112603850A (en) * | 2021-02-04 | 2021-04-06 | 雅弗生物实验室有限公司(加拿大) | Vitamin C permanent magnet whitening anti-aging film cloth and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101780041A (en) * | 2010-03-23 | 2010-07-21 | 南昌大学 | Polymer coated vitamin E liposome and preparation method thereof |
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| CN105943488A (en) * | 2016-06-30 | 2016-09-21 | 安徽天萝生物科技有限公司 | Loofah skincare mask and preparation method thereof |
| CN110859798A (en) * | 2019-10-31 | 2020-03-06 | 广州浚远康生物科技有限公司 | Anti-aging repairing mask liquid containing human umbilical cord mesenchymal stem cell secretion and preparation method thereof |
| CN112603850A (en) * | 2021-02-04 | 2021-04-06 | 雅弗生物实验室有限公司(加拿大) | Vitamin C permanent magnet whitening anti-aging film cloth and preparation method thereof |
| CN112603850B (en) * | 2021-02-04 | 2023-09-19 | 雅弗生物实验室有限公司(加拿大) | Vitamin C permanent magnet whitening anti-aging membrane cloth and preparation method thereof |
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