CN103479552B - Crease-resistant easypro eye cream alive and preparation method - Google Patents
Crease-resistant easypro eye cream alive and preparation method Download PDFInfo
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- CN103479552B CN103479552B CN201310455371.4A CN201310455371A CN103479552B CN 103479552 B CN103479552 B CN 103479552B CN 201310455371 A CN201310455371 A CN 201310455371A CN 103479552 B CN103479552 B CN 103479552B
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Landscapes
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Abstract
Crease-resistant easypro eye cream alive of the present invention, its component formula is: A phase: nanometer gold concentration is that the nano gold sol 13% of 400 μm of ol/L, butanediol 5%, carbomer 0.4%, water are appropriate; B phase: sad/last of the ten Heavenly stems triglyceride 2%, hydrogenated palm oil glycerides 3%, hexadecanol 2%, palmityl alcohol 2%, silantriol 0.5%, squalane 4%, chlorphenesin 0.2%, bisabolol 0.2%; C phase: Argireline 1%, Wushengtai 1%; D phase: Gherkin extract 0.5%, hyaluronic acid 0.5%, ascorbic acid 2%, MEIGUI CHUNLU 0.05%, Flos Inulae extraction 0.05%, green tea extract 0.05%; E phase: triclosan 0.1%, methyl hydroxybenzoate 0.1%, essence are appropriate.Its objective is and a kind of crease-resistant easypro eye cream alive and preparation method are provided, for nursing with improve aging, malnutrition or the skin by environmental nuisance provides a kind of unique combination thing.
Description
The application is the divisional application of " for nursing and improving compositions that is aging or damaged skin ", the applying date of original application is on 08 25th, 2011, application number is 201110244777.9, the invention and created name of original application is " for nursing and improving compositions that is aging or damaged skin ", and invention and created name during mandate is " a kind of crease-resistant moisturizer ".
Technical field
The present invention relates to cosmetic composition, described cosmetic composition comprises nanometer gold, for the energy source of skin cell metabolism and/or victory peptide class, one or more antioxidants.Can be used for nursing and improve aging, malnutrition or the skin by environmental nuisance, improvement can be provided in the visual appearance of skin, physiologic function, clinical characteristics and biophysics's characteristic aspect.
Technical background
Gold is used for skin protection and comes from ancient Egypt the earliest, and spun gold implants skin corium defying age, and in ancient Roman, doctor treats dermatosis with gold; In pharmacopeia on Chinese history, native gold has various different medical value, and the holy Li Shizhen (1518-1593 A.D.) Compendium of Material Medica of Ming Dynasty's medicine has been done to study record in great detail most to its property of medicine, consumption.Japan pharmacists Junichiro Koizumi flourish youth's work " revise and enlarge and examine with Chinese medicine " is also on the books.Nineteen eighty-three World Health Organization (WHO) (WHO) food additive regulations committee (CCFA), native gold was formally classified as food additive scope by the 16 meeting (Hague, Detch meeting), was classified as No. 310, A table the.
Nanometer gold has very strong adsorption function to protein, DNA etc., and can not change the character of adsorbed material, and the antibiotic property of nano gold sol, safety, toxicity have passed FDA (Food and Drug Adminstration) (FDA) certification.Nanometer gold is as the pharmaceutical carrier of good properties by investigation and application widely, and nanometer gold can play the effect of carrying active component Transdermal absorption, thus improves skin to the absorption of effective ingredient.
Studies have found that nanometer gold has promotion cell proliferation, the function enhanced metabolism more.Inventor also finds that nanometer gold all can promote cell proliferation to human skin cell within the scope of finite concentration, has dose dependent and time dependence, and on cell proliferation shows as significance facilitation and along with the increase of time, promotes that multiplication capacity strengthens.
Along with age ageing, the visual appearance of Long Term Contact adverse environmental factors or malnutrition skin, physical characteristic and physiological function change, and are considered to cosmetically institute less desirable.Often show as pachylosis, drying, sensitivity and fragility increase, cutis laxa clinically, elasticity reduces, wrinkle increases, atrophoderma, corium transparency increase and make glowing skin, but generally can maintain its whole geometry graphical appearance, often in canescence.These are all with the aging of age and hypometabolism, and Long Term Contact adverse environmental factors or malnutrition have close relationship.
Skin aging is prevented to be the eternal problem that cosmetics are researched and developed with the wrinkle that goes down in advance.
Because the outermost horny layer of skin itself has as defence from external allotrylic barrier physiological function, so just simply regards functionality is become to be distributed in external preparation, abundant Transdermal absorption can not be obtained, the effect that this composition is original can not be shown.Employ the Percutaneous absorption enhancers such as dimethyl sulfoxine, dimethyl formamide, dimethyl acetamide, methyldecyl sulfoxide in recent years, object improves the percutaneous absorbability of various material.But these Percutaneous absorption enhancers do not provide satisfied Transdermal absorption facilitation effect, and owing to there is erythema etc. by force and sometimes on skin to skin irritation, so, be not desirable especially in its effect, safety, use.
In order to improve the functional of functional type cosmetics, needing Persisting exploitation effective and there is no the functional cosmetic composition of negative interaction.
Nanometer gold has also been used in cosmetics, such as: Chinese patent: application number 200810045539.3 disclosed " a kind of preparation method of eye-care cosmetic " proposes a kind of formula and preparation method of the eye-care cosmetic containing nanometer gold.
Inventor finds, because nanometer gold self can promote the metabolism of skin, and the Transdermal absorption of other functional components can be promoted, nanometer gold, for the compositions of the energy source of skin metabolism and/or victory peptide class, one or more antioxidants in nursing with improve aging, malnutrition or show synergism characteristic by the skin of environmental nuisance.
Summary of the invention
The present invention by providing a kind of crease-resistant easypro eye cream alive containing nanometer gold and preparation method, for nursing with improve aging, malnutrition or the skin by environmental nuisance provides a kind of unique combination thing.
Described compositions contains: nanometer gold, for the energy source of skin cell metabolism and/or victory peptide class, one or more antioxidants.Wherein compositions is pressed the form configuration of cosmetic blend.
Nanometer gold with for skin cell metabolism energy source and/or win peptide class and one or more antioxidant combination, while nanometer gold self promotes cell metabolism, nanometer gold also promotes the Transdermal absorption of other material in compositions, and nanometer gold and for skin cell metabolism energy source and/or win between peptide class and antioxidant and produce synergism, thus create beyond thought beneficial effect.
The crease-resistant easypro eye cream alive of one of the present invention, its component formula is:
A phase: nanometer gold concentration is that the nano gold sol 13% of 400 μm of ol/L, butanediol 5%, carbomer 0.4%, water are appropriate;
B phase: caprylic/capric triglyceride 2%, hydrogenated palm oil glycerides 3%, hexadecanol 2%, palmityl alcohol 2%, silantriol 0.5%, squalane 4%, chlorphenesin 0.2%, bisabolol 0.2%;
C phase: Argireline 1%, Wushengtai 1%;
D phase: Gherkin extract 0.5%, hyaluronic acid 0.5%, ascorbic acid 2%, MEIGUI CHUNLU 0.05%, Flos Inulae extract 0.05%, green tea extract 0.05%;
E phase: triclosan 0.1%, methyl hydroxybenzoate 0.1%, essence are appropriate;
The content sum of each component of described crease-resistant easypro eye cream alive is 100%;
The preparation method of described crease-resistant easypro eye cream alive is: under the state that appropriateness stirs, heat A phase and B phase to 65 DEG C respectively, after stirring, B is added in A phase and also continues to stir until gained mixture mix homogeneously, then gained mixture be cooled to 50 DEG C and C is added to, continue to be cooled to 40 DEG C and add D phase, add E phase subsequently, be stirred to mix homogeneously, be cooled to 35 DEG C, obtain final product.
Compositions of the present invention can be included in cosmetic carrier.Cosmetic carrier can comprise emulsion, cream frost, washing liquid, solution, gel or ointment, or other carrier any well known by persons skilled in the art.In in concrete, emulsion can be emulsion oil-in-water or water-in-oil emulsion.Solution of the present invention can be, such as: aqueous solution or water-alcoholic solution.Anhydrous base material can be lip pomade or powder.
In other indefiniteness, compositions of the present invention can be included in aging products or humidified product, or is designed to provide in any product of benefit to skin.In concrete aspect, compositions can be applicable to using one day at least one times during use, twice, three times, four times, five times or more times.Compositions can also be chemical compatibility.
According to the present invention, described compositions contains such as Lactobacillus ferment, the wheat protein of hydrolysis, glycine, arginine and this kind of energy source for skin cell metabolism of methionine, the victory peptide class that described compositions contains is selected from: two victory peptides, palmitoyl tripeptide 3, four victory peptides, Wushengtai, Argireline, seven victory peptides, eight victory peptides, nine victory peptides or their mixture, one or more antioxidants that described compositions contains are selected from: nicotiamide, vitamin A and derivant thereof, vitamin E and derivant thereof, ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbate, ascorbyl polypeptide, ascorbyl dipalmitate, methyl silicane alcohol ascorbic acid, ascorbyl stearate, ascorbyl tocopheryl potassium phosphate, cysteine, tocopherol and derivant thereof, ferulic acid, epicatechol gallate, gallateoctylester, propyl gallate, PGS, tocopherol acetas, Vitamin E linoleate, tocopheryl nicotinate, fertility succinate, rosmarinic acid, superoxide dismutase, catalase, glutathione peroxidase, metallothionein, Fructus Chaenomelis sulfydryl enzyme, coenzyme Q10 or their mixture.
This cosmetic composition can comprise by weight of the composition 0.01% to 30%, preferably 0.1% to 9% the energy source for skin cell metabolism and/or victory peptide class; Compositions comprises by weight of the composition 0.05% to 20%, preferably one or more antioxidants of 0.1 to 9%.
The present composition is for improving the skin vision outward appearance, physiologic function or the biophysical properties that change by many factors.Wherein said factors such as age ageing, chronic sun exposure, adverse environment condition, such as pollutant, family apply some make up, disease pathology, smoking or underfed factor.Wherein the change of said visual appearance comprises, such as, the appearance of microgroove and wrinkle, depression increase, loss of elasticity, loss of firmness and loss of color evenness, coarse texture, mottled pigmentation, its these and other aspect of the present invention is done below and is further described in detail.
A nanometer gold
Studies have found that nanometer gold has promotion cell proliferation more, the function enhanced metabolism, inventor also finds that nanometer gold also all can promote cell proliferation to human skin cell within the scope of finite concentration, there is dose dependent and time dependence, on cell proliferation shows as significance facilitation and along with the increase of time, promote that multiplication capacity strengthens, nanometer gold does not affect cancerous cell simultaneously, and the age of copying life time and donor that fibroblast in-vitro multiplication ability detects all ages and classes human skin fibroblast is negative correlation, the replication in vitro life time that the donor age often increases its cell one-year-old reduced for 0.2 generation.
Nanometer gold self can promote the metabolism of skin, can promote the Transdermal absorption of other functional components, the compositions of the energy source of nanometer gold, skin metabolism and/or victory peptide class, one or more antioxidants is in nursing and improve aging, malnutrition or show synergism characteristic by the skin of environmental nuisance.
B is used for the energy source of skin cell metabolism
In a typical implementation, described energy source comprises Lactobacillus ferment.In particular embodiments, described energy source origin is hung oneself the phosphagen-derived molecules composition of microorganism of biotechnology modified.It is made up of the wheat protein of glycerol, Lactobacillus ferment, hydrolysis, glycine, arginine and methionine.As embodiment, this energy source can trade name PHOSPHOVITAL
tMbe commercially available, on sale in French Si Dama company.This material provides the energy source for skin cell metabolism.The working concentration of this material in formula is more than 0.05% to 30% or 30%.
C antioxidant
Antioxidant is that a class can help to catch also and free radical, thus dispels a class material of radical pair human body infringement.Radical reaction causes an old and feeble key factor, and scientist is by experimental results demonstrate that free-radical oxidation is the major reason causing aging, cell injury and degeneration.Free radical is the harmful substance that a class is present in the energy damaging cells in body cell.In the biological chain type course of reaction of one in body, the existence of free radical impels the old and feeble materials such as skin histology interior generation melanin, lipofuscin and ceroid.Biological itself have defence capability to free radical, but this ability increases along with the age and progressively goes down, active attenuating.
D cosmetic carrier
Compositions of the present invention is all effective in all types of cosmetic carrier.The nonlimiting examples of suitable cosmetic carrier comprises emulsion, cream, washing liquid, solution (moisture and water-alcoholic), anhydrous base material (e.g., lip pomade and powder), gel and ointment, or by other method or aforesaid any combination, as those skilled in the art can know, change and use in the present invention with other suitable carriers apparent to those skilled in the art being suitable for.
In preferred embodiments, cosmetic carrier is selected from emulsion oil-in-water, the encapsulate pearl in water-ol solution or anhydrous system.With regard to emulsion oil-in-water, this emulsion and composition and production method be well known in the art.But importantly select concentration and the combination of compound and extract, combination is that chemical is compatible, and does not form complex and precipitate from finished product.
E beautification product
Compositions of the present invention can also be used for, in a lot of beautification product, including but not limited to, humidification cream, beneficial skin cream and washing liquid, gel, ointment, foundation cream, late frost, lip pomade, cleaning agent, toner, facial film and/or color cosmetic products.Compositions first-selection is used for, in aging products, for face and other body parts, the most particularly staying the product on skin.
Other compound used together with F can combine with the present invention and reagent
Compositions of the present invention can contain other beneficial agents and compound, and such as, acute or chronic moisturizing agents (comprises, such as, wetting agent, occludent and the reagent affecting skin natural moisturization mechanism), plant extract, antioxidant, skin whitener is (such as, hydroquinone), emollient, counter-stimulus, vitamin, trace metal, antimicrobial, aromatic and/or dyestuff and coloring components.
Detailed description of the invention
The crease-resistant easypro eye cream alive of embodiment 1
Step: under the state that appropriateness stirs, heat A phase and B phase to 65 DEG C respectively, is added to B after stirring in A phase and also continues to stir until gained mixture mix homogeneously.Then described mixture be cooled to 50 DEG C and C is added to, continue to be cooled to 40 DEG C and add D phase, adding E phase subsequently, be stirred to mix homogeneously, being cooled to 35 DEG C.
Although more than describe and append illustrative embodiment of the present invention, certainly should be understood that, those skilled in the art obviously can carry out various improvement.
Claims (2)
1. a crease-resistant easypro eye cream alive, is characterized in that: component formula is:
A phase: nanometer gold concentration is that the nano gold sol 13% of 400 μm of ol/L, butanediol 5%, carbomer 0.4%, water are appropriate;
B phase: caprylic/capric triglyceride 2%, hydrogenated palm oil glycerides 3%, hexadecanol 2%, palmityl alcohol 2%, silantriol 0.5%, squalane 4%, chlorphenesin 0.2%, bisabolol 0.2%;
C phase: Argireline 1%, Wushengtai 1%;
D phase: Gherkin extract 0.5%, hyaluronic acid 0.5%, ascorbic acid 2%, MEIGUI CHUNLU 0.05%, Flos Inulae extract 0.05%, green tea extract 0.05%;
E phase: triclosan 0.1%, methyl hydroxybenzoate 0.1%, essence are appropriate;
The content sum of each component of described crease-resistant easypro eye cream alive is 100%;
The preparation method of described crease-resistant easypro eye cream alive is: under the state that appropriateness stirs, heat A phase and B phase to 65 DEG C respectively, after stirring, B is added in A phase and also continues to stir until gained mixture mix homogeneously, then gained mixture be cooled to 50 DEG C and C is added to, continue to be cooled to 40 DEG C and add D phase, add E phase subsequently, be stirred to mix homogeneously, be cooled to 35 DEG C, obtain final product.
2. prepare the method for crease-resistant easypro eye cream alive according to claim 1 for one kind, it is characterized in that: under the state that appropriateness stirs, heat A phase and B phase to 65 DEG C respectively, after stirring, B is added in A phase and also continues to stir until gained mixture mix homogeneously, then gained mixture is cooled to 50 DEG C and C is added to, continue to be cooled to 40 DEG C and add D phase, adding E phase subsequently, be stirred to mix homogeneously, be cooled to 35 DEG C, obtain final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110244777 CN102440943B (en) | 2011-08-25 | 2011-08-25 | Anti-wrinkle moisturizing lotion |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110244777 Division CN102440943B (en) | 2011-08-25 | 2011-08-25 | Anti-wrinkle moisturizing lotion |
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| CN103479552A CN103479552A (en) | 2014-01-01 |
| CN103479552B true CN103479552B (en) | 2015-10-21 |
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| CN201310455371.4A Active CN103479552B (en) | 2011-08-25 | 2011-08-25 | Crease-resistant easypro eye cream alive and preparation method |
| CN201310455248.2A Active CN103479551B (en) | 2011-08-25 | 2011-08-25 | Cosmetic water and preparation method |
| CN 201110244777 Active CN102440943B (en) | 2011-08-25 | 2011-08-25 | Anti-wrinkle moisturizing lotion |
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| CN 201110244777 Active CN102440943B (en) | 2011-08-25 | 2011-08-25 | Anti-wrinkle moisturizing lotion |
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| CN102772309B (en) * | 2012-07-12 | 2013-08-07 | 启东安升润液设备有限公司 | Eye cream |
| CN102824285B (en) * | 2012-07-25 | 2013-09-11 | 诺斯贝尔(中山)无纺日化有限公司 | Vitamin B (VB) face cream cosmetic containing 24K gold |
| CN103356475B (en) * | 2013-08-05 | 2014-09-10 | 唯美度科技（北京）有限公司 | Wrinkle-removing and skin-tendering lotion |
| CN103417433B (en) * | 2013-08-05 | 2015-04-22 | 雅露拜尔生物科技（杭州）有限公司 | Whitening and freckle-removing cream with whitening and freckle-removing functions, production technology of cream, and nitrogen filling machine |
| CN103816071A (en) * | 2013-12-23 | 2014-05-28 | 青岛安信医疗器械有限公司 | Skin lotion |
| CN104740672A (en) * | 2013-12-31 | 2015-07-01 | 上海建华精细生物制品有限公司 | Chitosan gold nano-particle compound as well as preparation method and application thereof |
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| CN103479551B (en) | 2015-10-21 |
| CN103479552A (en) | 2014-01-01 |
| CN102440943A (en) | 2012-05-09 |
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