CN110693759A

CN110693759A - Anti-aging cosmetic and preparation method thereof

Info

Publication number: CN110693759A
Application number: CN201911138489.8A
Authority: CN
Inventors: 冯波; 苏丹; 沈晓龙; 石九曜
Original assignee: Liaoning Yan Yang Medical Equipment Co Ltd
Current assignee: Liaoning Yan Yang Medical Equipment Co Ltd
Priority date: 2019-11-19
Filing date: 2019-11-19
Publication date: 2020-01-17

Abstract

An anti-aging cosmetic comprises nano chitosan, nano gold, vitamin C and derivatives thereof, a humectant, a skin conditioner 1, a skin conditioner 2, other components and water, wherein the sum of the weight percentages of the components is 100%, the weight ratio of the nano chitosan to the nano gold is 1 (1 ~ 5). the cosmetic prepared by the invention has the effects of moisturizing, brightening, resisting oxidation and resisting aging, and the nano chitosan and the nano gold are jointly used in a certain proportion to show the enhancement effect on the aspects of promoting skin metabolism and restoring skin elasticity, and can promote the spreadability of the cosmetic.

Description

Anti-aging cosmetic and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to an anti-aging cosmetic and a preparation method thereof.

Background

With the influence of adverse factors such as aging and external pollution, the skin is often rough, dry, more sensitive and fragile, loose, less elastic, more wrinkles, skin atrophy and the like, which is contrary to the current demand of people for fine, smooth, water-oil balanced, wrinkle-free and elastic skin. The prevention of skin aging and wrinkle reduction in advance, and the water replenishing and moisture retention are the constant subjects of cosmetic development.

Gold was first used for skin care from ancient egypt, where gold wire was implanted in the dermis layer for anti-aging, while in ancient roman, doctors used gold for treatment of skin diseases; in the Chinese historical pharmacopoeia, gold foil has various medicinal values. Gold is not readily absorbed by the human body.

The nano gold has strong adsorption function to protein, DNA and the like, and the property of the adsorbed substance is not changed, and the antibacterial property, the safety and the toxicity of the nano gold sol are certified by the United states food and drug administration. The nano gold can be used as a drug carrier, can carry active ingredients to be absorbed through skin, and improves the absorption rate of the skin to the active ingredients. Modern researches also find that the nanogold has the functions of promoting cell proliferation and promoting metabolism.

Chitosan, as a natural biomaterial, is widely used in the fields of food, medicine, cosmetics, etc. due to its excellent biocompatibility, nontoxicity, cell growth promoting activity, biodegradability, etc. In the application of chitosan in the cosmetic field, the excellent antibacterial, film-forming and moisturizing effects of chitosan are mainly surrounded, and no other effects of chitosan in cosmetics are developed.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides an anti-aging cosmetic which has excellent moisturizing, brightening, anti-oxidation and anti-aging effects, and the effect of synergistically increasing anti-aging and stability by using nano-gold and chitosan is creatively developed.

The technical scheme adopted by the invention is as follows:

an anti-aging cosmetic comprises the following components: nano chitosan, nano gold, vitamin C and derivatives thereof, a humectant, a skin conditioner 1, a skin conditioner 2, other components and the balance of water, wherein the sum of the weight percentages of the components is 100%; wherein the weight ratio of the nano chitosan to the nano gold is 1 (1-5).

An anti-aging cosmetic comprises the following components in percentage by weight: 0.5-5% of nano chitosan, 0.5-3.5% of nano gold, 1-10% of vitamin C and derivatives thereof, 1-18% of humectant, 11-9% of skin conditioner, 21-8% of skin conditioner, 1-8.5% of other components and the balance of water; the sum of the weight percentages of the components is 100 percent.

Preferably, the ratio of the nano chitosan to the nano gold is 1 (1-5), and more preferably, the ratio of the nano chitosan to the nano gold is 1: 1.12.

Preferably, the molecular weight of the nano chitosan is 1000-50000Da, the deacetylation degree is 70-95%, and the particle size is 10-100 nm.

Preferably, the particle size of the nano gold is 10-80 nm.

Preferably, the vitamin C and the derivatives thereof are selected from one or more of 3-O-ethyl ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate and ascorbyl tetraisopalmitate.

Preferably, the humectant is one or more selected from polyhydric alcohols, natural moisturizing factors, amino acids and molecular biochemical humectants. More preferably, the polyalcohol is one or more selected from methyl propylene glycol, glycerol, butanediol, hexanediol, octaethylene glycol, polyethylene glycol, polypropylene glycol, xylitol, sorbitol, and glyceryl polyether-26. More preferably, the amino acid humectant is selected from betaine and natural methylglycine proline. More preferably, the natural moisturizing factor is selected from one or more of amino acid, pyrrolidone carboxylic acid, sodium lactate and urea, and more preferably, the biochemical substances are selected from one or more of collagen, hyaluronic acid, sodium hyaluronate, glycoprotein, chondroitin sulfate and ceramide.

Preferably, the skin conditioner 1 is one or more of nicotinamide, glycyrrhizic acid dimethyl, grape polyphenol, tea polyphenol, resveratrol, palmitoyl tripeptide-8, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, nonapeptide-1, acetyl hexapeptide-8 and dipeptide.

Preferably, the skin conditioner 2 is a plant extract selected from two or more of seaweed extract, grape seed extract, ophiopogon root extract, prickly pear cactus extract, chinaroot greenbrier rhizome extract, peony extract, licorice extract, atractylodes macrocephala extract, leonurus extract, salvia miltiorrhiza extract, sophora flavescens extract, ginseng extract, sansevieria trifasciata extract, purslane extract, whiteflower hogfennel root extract, astragalus extract, bletilla striata extract, smilax glabra extract, chamomile extract, imperata cylindrica extract, witch hazel extract and raspberry extract.

Preferably, the other component is a mixture of a chelating agent, an emulsifier, a thickener, a preservative, a fragrance, and the like. More preferably, the chelating agent is one of disodium ethylene diamine tetraacetate and tetrasodium ethylene diamine tetraacetate. More preferably, the emulsifier is one of C10-30 alkanol acrylate cross-linked polymer, acrylamide copolymer and Tween 85. More preferably, the thickener is one of hydroxyethyl cellulose, carboxypropyl cellulose, methyl cellulose and ethyl cellulose. More preferably, the preservative is one or two of potassium sorbate, phenoxyethanol, 1, 2-hexanediol, p-hydroxyacetophenone and propyl hydroxybenzoate.

The invention also provides a preparation process of the anti-aging cosmetic, which comprises the following steps:

(1) adding a part of humectant into water, stirring for 5-10min to be uniform, adding nanogold in batches, and performing ultrasonic treatment to be uniform to obtain liquid A; (ii) a Adding water-soluble vitamin C and its derivatives into water, stirring for 5-10min to uniformity, adding nano chitosan in batches, and performing ultrasonic treatment to uniformity to obtain liquid B;

(2) mixing part of the humectant, the skin conditioner 1 and the thickening agent in a mixer, heating to homogeneous phase while stirring, heating to 80-85 deg.C, vacuumizing, defoaming, and maintaining the temperature for 30 min;

(3) adding the rest materials into the mixture obtained in the step (2), mixing, stirring for 10-20min to be uniform, and keeping stirring for 30 min;

(4) cooling to 38 deg.C, adding liquid A and liquid B into (3), respectively, stirring for 5min, stirring for 20min, stopping stirring, discharging, inspecting, packaging, and making into final product.

Compared with the prior art, the invention has the beneficial effects that:

(1) the invention creatively discovers that the nano chitosan and the nano gold are jointly used in a certain proportion to show the enhancement effect on the aspects of promoting the skin metabolism and restoring the skin elasticity, and can promote the spreadability of cosmetics.

(2) In the components of the invention, vitamin C and/or derivatives can lighten skin color, promote the growth of collagen cells and change the elasticity of skin. The humectant can supplement water and keep moisture. The skin conditioner has antioxidant, tightening, and melanin inhibiting effects. The components of the invention cooperate together to play the roles of moisturizing, brightening, resisting oxidation and resisting aging.

Drawings

Fig. 1 is a spreading test chart of cosmetics.

Fig. 2 is a photograph of a sample of anti-aging cosmetic prepared according to the present invention.

Fig. 3 is a cell diagram before and after the anti-aging cosmetic prepared by the present invention is used.

Detailed Description

The following examples are given to further illustrate the embodiments of the present invention, but are not intended to limit the invention.

The chitosan is natural polysaccharide, is safe, non-toxic and biologically friendly, and has no stimulation to skin and no anaphylactic reaction. The nano chitosan enters the skin, is metabolized by enzyme and then is decomposed into glucosamine, acetyl glucosamine or a glucose compound and the like, and the absorbed nano chitosan can provide energy or active compounds for cells, accelerate the metabolism or regeneration of the cells, activate the skin, improve the elasticity of the skin and enable the skin to be in a young state. Chitosan is a natural moisturizing factor and can moisturize the skin. The chitosan also has obvious bacteriostatic action and obvious action on acne and the like caused by skin inflammation.

The nanogold can improve charges or micro-electric fields in the skin, remove free radicals, accelerate skin circulation, improve cell renewal speed, promote metabolism, recover skin elasticity of loose skin, lighten or disappear tiny wrinkles, enable the loose skin to return to a compact state, delay the generation of the wrinkles and achieve the aim of resisting aging.

The size of the nano chitosan is 10-100nm, the size of the nano gold particles is 10-80nm, and the nano chitosan can rapidly penetrate through the stratum corneum of the skin barrier without barrier and enter the inside of the skin to reach the deep part of the skin. The nano particles have high specific surface energy, are easy to adsorb active ingredients, and bring the active ingredients into the deep layer of the skin, so that the active ingredients can exert the effect more effectively.

In the research and development process, the inventor intends to develop a nano gold essence system, but in the research and development process, the inventor unexpectedly finds that the nano chitosan and the nano gold are simultaneously added into the cosmetic essence, so that the cosmetic essence has a better anti-aging effect than the cosmetic essence with the nano gold essence or the nano chitosan essence, the spreadability of the cosmetic essence is better, and the stability is higher, namely, the nano chitosan and the nano gold are simultaneously added, so that the synergistic effect is achieved.

The inventors carried out the following experiments to verify:

and (3) effect testing:

1. anti-aging Effect test

6 groups of mice were taken, 3 each. In 5 groups, 1-5 samples are respectively wiped, and the other group is not coated with the product, the dorsal epidermis of five-haired mice is irradiated by ultraviolet rays, and the light and heavy degrees of erythema formation, thickening, desquamation, shrinkage and the like are observed.

The test results show that the anti-UV aging effect of the

groups

2, 3 and 4 is better than that of the

groups

1 and 5, wherein the effect of the group 3 is the best.

2. Spreadability test

The quality or popularity of a cosmetic product is determined, in part, by the efficacy of the product and, in part, by the skin feel of the application. An important item in skin feel is spreadability, a cosmetic with good spreadability, which is convenient to spread and absorb. The rheological test of the cosmetics can objectively and quantitatively represent the spreadability of the cosmetics, and meanwhile, the stability of the cosmetics can be reflected to a certain degree.

The prepared cosmetics of the above 5 groups were subjected to a viscosity (spreadability) test, and the results are shown in fig. 1. The viscosity becomes smaller with the increase of the shearing force, which shows that the product is easy to spread, and as can be seen from the curve in fig. 1, the spreading performance of the products of

groups

2, 3 and 4 is better than that of the products of

groups

1 and 5, which shows that the spreading performance of the cosmetic essence prepared by only adding the nano-gold or the nano-chitosan is not better than that of the cosmetic essence added with the nano-gold and the nano-gold together.

3. Stability test

And (3) heat resistance test: firstly, adjusting an electric heating constant temperature incubator to 40 +/-1 ℃, placing one of 1-5 groups of samples in the electric heating constant temperature incubator for 24 hours, taking out the samples, recovering the room temperature, then comparing the 1-5 groups of samples with the other samples, and observing whether phenomena such as thinning, discoloration, layering, hardness change and the like exist so as to judge the heat resistance of the product.

Cold resistance test: firstly, the refrigerator is adjusted to (-5 to-15) DEG C +/-1 ℃, 1-5 groups of samples are respectively placed in the refrigerator for 24 hours, then taken out, and the 1-5 groups of samples are compared with one another after the temperature is restored to the room temperature, and whether the phenomena of thinning, discoloration, layering, hardness change and the like exist or not is observed, so as to judge the cold resistance of the product.

Based on the basic system, the inventor continues to develop the system, and finally obtains a cosmetic system with good effect. The weight percentages of the components of the anti-aging cosmetics of the present invention according to examples 1 to 5 and comparative examples 1 to 2 are shown in the following table (unit:%).

The invention relates to a preparation process of an anti-aging cosmetic, which specifically comprises the following steps:

(1) adding a part of humectant into water, stirring for 5-10min to be uniform, adding nanogold in batches, and performing ultrasonic treatment to be uniform to obtain liquid A; adding water-soluble vitamin C and its derivatives into water, stirring for 5-10min to uniformity, adding nano chitosan in batches, and performing ultrasonic treatment to uniformity to obtain liquid B;

And (3) effect testing:

1. moisturizing effect test

140 test subjects were selected and divided into 7 groups of 20 subjects, and the anti-aging cosmetics of examples 1 to 5 and comparative examples 1 to 2 of the present invention were used, respectively. The tested person takes 5g of the anti-aging cosmetic to be evenly smeared on the face 2 times a day for 30 days continuously so as to evaluate the product performance.

The skin moisture tester is adopted to test the changes of the skin moisture content of the testee before use, 10 days, 20 days and 30 days, the data is recorded, and the average value is taken. The measured face area and the measured environment temperature and humidity are kept consistent. The moisturizing effect test results are shown in the following table.

The above results show that the moisture content of the skin is increased after 30 days of using the anti-aging cosmetic of the present invention, which shows that the anti-aging cosmetic of the present invention has excellent moisturizing effect. The cosmetic added with the nano chitosan and the nano gold has better effect on promoting the water content of the skin than the cosmetic added with the nano particles, and the water content of the skin is obviously improved when the ratio of the nano chitosan to the nano gold is 1: 1.12.

2. Skin elasticity test

The skin elasticity change of the test subjects before, 10 days, 20 days, and 30 days after the use was measured by using a PVM600 probe using MPA580 skin elasticity tester of CK company, Germany, and the data was recorded, and the average value of R2 was taken. The measured face area and the measured environment temperature and humidity are kept consistent. The skin elasticity test is shown in the following table.

MPA580 skin elasticity tester test principle is based on the principle of suction and tension, and negative pressure is generated on the surface of the skin to be tested to suck the skin into a specific test probe, and the depth of the skin sucked into the test probe is measured by a non-contact optical test system. R2 ═ Ua/Uf, where Ua-the recovery value of the skin from the removal of negative pressure to the next successive test of skin surface plus negative pressure, and Uf-the maximum amount of stretching of the skin in the presence of negative pressure. The younger the skin, the more elastic the skin, the closer the R2 value is to 1.

The above results show that the skin elasticity is improved after 30 days using the anti-aging cosmetic of the present invention, indicating that the anti-aging cosmetic of the present invention has skin elasticity improving, anti-aging effects. The cosmetic added with the nano-chitosan and the nano-gold has better effect on improving the skin elasticity than the cosmetic added with a nano-particle alone, and the skin elasticity improving capability is obviously strongest when the ratio of the nano-chitosan to the nano-gold is 1:1.12, which shows that the nano-gold and the nano-chitosan play a role in synergy on the aspect of improving the skin elasticity in the cosmetic of the invention.

3. Skin lightening efficacy test

140 test subjects with dull skin, acne marks or color spots were selected and divided into 7 groups of 20 subjects, and the anti-aging cosmetics of examples 1 to 5 and comparative examples 1 to 2 of the present invention were used, respectively. The skin improvement condition of the test person is observed and photographed after the test person takes 5g of the anti-aging cosmetic to be evenly smeared on the face for 30 days continuously for 2 times a day.

After the anti-aging cosmetic is used by a test person for 15 days, the skin color is slightly lightened, and the acne color spots begin to become dull. After 30 days of use, the skin color is obviously lightened, and the acne marks and stains are lightened. The trial results show that the anti-aging cosmetic has good skin color brightening effect.

A photograph of an anti-aging cosmetic sample prepared according to the present invention is shown in FIG. 2.

Fig. 3 is a graph showing cell changes before and after the anti-aging cosmetic prepared in example 3 was used, in which a is the cell change after ultraviolet irradiation without applying the product, b is the cell change after ultraviolet irradiation after applying the product of the present invention, and c is the cell change after applying the product of the present invention after ultraviolet irradiation. Generally, the cell thickness is increased after ultraviolet irradiation, whether the product is effective or not is mainly determined by the cell thickness, and the cell thickness in the graph b and the graph c is obviously thinner than that in the graph a, which shows that the anti-aging effect of the product is better.

The above results are combined to show that the anti-aging cosmetic of the present invention has a superior anti-aging effect.

Claims

1. An anti-aging cosmetic is characterized by comprising the following components of nano chitosan, nano gold, vitamin C and derivatives thereof, a humectant, a skin conditioner 1, a skin conditioner 2, other components and the balance of water, wherein the sum of the weight percentages of the components is 100%, and the weight ratio of the nano chitosan to the nano gold is 1 (1 ~ 5).

2. The anti-aging cosmetic according to claim 1, characterized by consisting of the following components in percentage by weight: 0.5-5% of nano chitosan, 0.5-3.5% of nano gold, 1-10% of vitamin C and derivatives thereof, 1-18% of humectant, 11-9% of skin conditioner, 21-8% of skin conditioner, 1-8.5% of other components and the balance of water; the sum of the weight percentages of the components is 100 percent.

3. The anti-aging cosmetic as claimed in claim 2, wherein the ratio of nano chitosan to nano gold is 1 (1 ~ 5).

4. The anti-aging cosmetic according to claim 3, wherein the ratio of the nano chitosan to the nano gold is 1: 1.12.

5. The anti-aging cosmetic as claimed in any one of claims 1 to 2, wherein the nano chitosan has a molecular weight of 1000-50000Da, a degree of deacetylation of 70-95%, and a particle size of 10-100 nm.

6. The antiaging cosmetic according to any one of claims 1 to 2, wherein the nanogold has a particle size of 10 to 80 nm.

7. The antiaging cosmetic according to claim 1-2, wherein the vitamin C and its derivative are selected from one or more of 3-o-ethyl ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, and ascorbyl tetraisopalmitate.

8. The antiaging cosmetic according to any one of claims 1 to 2, wherein the humectant is one or more selected from polyhydric alcohols, natural moisturizing factors, amino acids, molecular biochemical humectants; more preferably, the polyalcohol is one or more selected from methyl propylene glycol, glycerol, butanediol, hexanediol, caprylyl glycol, polyethylene glycol, polypropylene glycol, xylitol, sorbitol, and glyceryl polyether-26; more preferably, the amino acid humectant is selected from betaine, natural methylglycine proline; more preferably, the natural moisturizing factor is selected from one or more of amino acid, pyrrolidone carboxylic acid, sodium lactate and urea; more preferably, the biochemical substances are selected from one or more of collagen, hyaluronic acid, sodium hyaluronate, glycoprotein, chondroitin sulfate and ceramide.

9. The anti-aging cosmetic according to any one of claims 1 to 2, wherein the skin conditioner 1 is one or more selected from the group consisting of niacinamide, glycyrrhizin dimethyl, grape polyphenol, tea polyphenol, resveratrol, palmitoyl tripeptide-8, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, nonapeptide-1, acetyl hexapeptide-8, and dipeptide;

the skin conditioner 2 is a plant extract selected from two or more of seaweed extract, grape seed extract, radix ophiopogonis extract, prickly pear cactus extract, smilax glaber root extract, peony extract, licorice extract, bighead atractylodes rhizome extract, motherwort extract, salvia miltiorrhiza extract, sophora flavescens extract, ginseng extract, sansevieria trifasciata extract, purslane extract, whiteflower hogfennel root extract, astragalus extract, bletilla striata extract, glabrous greenbrier rhizome extract, chamomile extract, feverfew extract, witch hazel extract and raspberry extract;

the other components are various mixtures of chelating agents, emulsifiers, thickeners, preservatives, flavoring agents and the like;

more preferably, the chelating agent is one of disodium ethylene diamine tetraacetate and tetrasodium ethylene diamine tetraacetate; more preferably, the emulsifier is one of C10-30 alkanol acrylate cross-linked polymer, acrylamide copolymer and Tween 85; more preferably, the thickening agent is one of hydroxyethyl cellulose, carboxypropyl cellulose, methyl cellulose and ethyl cellulose; more preferably, the preservative is one or two of potassium sorbate, phenoxyethanol, 1, 2-hexanediol, p-hydroxyacetophenone and propyl hydroxybenzoate.

10. The preparation process of the anti-aging cosmetic is characterized by comprising the following steps:

(2) mixing part of the humectant, the skin conditioner 1 and the thickening agent under stirring, heating to homogeneous phase under stirring at 80-85 deg.C, vacuumizing, defoaming, and maintaining for 30 min;

(4) cooling to 38 ℃, respectively adding the liquid A and the liquid B into the mixture (3), stirring for 5min to be uniform, and keeping stirring for 20min to obtain the liquid.