CN107625663A - A kind of basic aqua of glycolipid containing high-purity rhamnazin and its application - Google Patents
A kind of basic aqua of glycolipid containing high-purity rhamnazin and its application Download PDFInfo
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Abstract
The invention discloses a kind of basic aqua of glycolipid containing high-purity rhamnazin and its application, the basic aqua includes rhamnolipid and hyaluronic acid.Basic aqua of the present invention can reach skin corium with skin permeation epidermis, participate in blood circulation, promote fibroblast growth rate, accelerate collagen generation, add the structure and tensile strength of deep skin, play the effect of crease-resistant.Preservative free composition in basic aqua of the present invention, and there is anti-inflammatory, antianaphylactic effect, tool has been widely used.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of basic aqua that skin collagen can be accelerated to generate
Preparation method and application.
Background technology
Collagen is most important part in extracellular matrix, contains a large amount of carboxyls and hydroxyl.World's collagen egg
White father Brant doctor asserts：" process of human senility is exactly the process that collagen is lost in！”.Containing big in collagen
The amino acid of carboxyl and hydroxyl is measured, such as hydroxyproline, hydroxylysine and glycine NMF, is had very to skin
Good moistening effect.Therefore, collagen is widely used in cosmetic field as important anti-ageing composition.
At present, collagen is mainly extracted from animal connective tissue and obtained, but the collagen egg extracted from animal tissue
Zoonosis, hormone remaining equivalent risk be present in vain, limit its potential application and exploitation.
Collagen is also prevalent in gelatinous food, but the collagen in these common foods is all macromolecular
It protein, can not be directly absorbed by the body, and easily cause accumulation of cholesterol.Existing market has many collagen beverages, piece
Agent etc., the collagen contained by it has all resolved into by the digestion overwhelming majority has lost collagen and its entire molecule knot
The small molecule product of structure and function, it is systemic distribution, conversion and degraded again after absorption, can finally reaches the collagen of skin
It is fairly limited.And it is very small in the regeneration rate of human body by the collagen after Gastric juice digestion, do not reach anti-ageing purpose.
Further, it is also possible to pass through external source acquisition collagen, presently the most effectively micropin introductory technique, but micropin imports
Afterwards, skin is in damage state, the symptoms such as bleeding, redness, hyperplasia easily occurs, actual effect has individual difference.External application is made up,
The products such as skin care, because collagen from foreign matter kind and is macromolecular, external application is difficult to largely enter skin, especially deep layer skin
Skin, such as skin corium, and the main key position for determining collagen amount and reaching beauty, crease-resistant and other effects is only here.These
Can not enter skin and be deposited in skin surface collagen be the excellent culture medium of microorganism, extremely profit its rapidly breed and produce
Raw toxin, endangers skin and physical and mental health on the contrary.
Due to including a large amount of greases, vitamin, amino acid and moisture in raw material of skin care articles, these are all that Institute of Micro-biology needs
Various trophic factors, easy breed bacteria and microorganism, so as to trigger the putrid and deteriorated of product, user has used rotten cosmetic
Grade is also easy to produce allergy, skin infection, serious threat to life.In order to avoid case above occurs, existing market is largely protected
The different degrees of addition single of skin product or Determination of Preservatives.These preservative molecules amounts are very small to be easily absorbed by the skin, and
Accumulated in skin corium, long-term use can exist potentially hazardous to skin, and some influence whether the barrier action of skin, make cutin
The problems such as cell loosely causes cell coarse easily sensitive.Therefore, we are necessary to find a kind of substitute products, solve or reduce
The skin problem that preservative is brought.
The content of the invention
For problems of the prior art, the invention provides a kind of basic aqua of glycolipid containing high-purity rhamnazin,
Comprising rhamnolipid, hyaluronic acid, active VC, carrier components and anti-inflammatory component, have and promote collagen fabric mother cell to increase
Value, increase autologous collagen albumen yield the effect of, avoid the loss of autologous collagen albumen while eliminate preservative to skin
Harm.Inherently solve the problems, such as that external source/human-like collagen is prepared, absorbed.
In order to solve the above technical problems, the present invention uses following technical scheme：
A kind of basic aqua, it is characterised in that include rhamnolipid and hyaluronic acid.With promotion nutrient absorption, promote
The effect of producing the propagation of the fibroblast of collagen, so as to reach crease-resistant effect.
Preferably, the rhamnolipid content is 5-50mg/L, and the rhamnolipid is 98.0-99.9% high-purity rhamnazins
Glycolipid.Experiment show that using 98%-99.9% high-purity rhamnazin glycolipid under identical environment, caused effect is best.
Preferably, the hyaluronic acid 5-20mg/L.Hyaluronic acid repair ability in a organized way, being mixed with rhamnolipid makes
With can preferably promote to produce the propagation of the fibroblast of collagen, and prevent the loss of collagen.
A kind of basic aqua described above, also comprising active VC, the active VC is L-vitamin C, vitamin C sugar
Glycosides, VC-IP, COS-VCE, lemon extract, cyanidin extract, malpighia glabra extract, Japanese stingless rose extract
In one or more.In the building-up process of collagen in vivo, the dihydroxylation process of proline can be aided in by adding active VC,
It is effectively promoted the propagation for the fibroblast for producing collagen.
Preferably, the active VC contents are 0.1-1g/L.
A kind of basic aqua described above, also comprising preparation water, the preparation water is to drink rank mineral water.
Preferably, it is described drink rank mineral water refer to it is total rich in the human body beneficial mineral matter element such as strontium, zinc, selenium, dissolubility
Solid is less than 280ppm pure water.
A kind of basic aqua described above, comprising carrier components, the carrier components comprise at least 1,2- hexylene glycols, 10-
Hydroxydecanoic acid, gum arabic, acai berry extract, acetylcarnitine hydrochloric acid, acetylglucosamine, acetoglyceride castor-oil plant alcohol
Acid esters, acetyl hexapeptide, acetyl tributyl citric acid, Acetyl Tyrosine, acetylated castor oil, acetylated hydrogenated cottonseed glycerine, second
Acylated lanolin, acetulan, acetylation palm kernel glycerides, acetylsalicylic acid, acrylate, acrylic ester copolymer
Thing, adenylate, adenine, atriphos, White mushroom extract, Agrimonia eupatoria leaf extract, beautiful Yi Gucao extracts,
Xinjiang Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) extract, albumin, garment or robe made of feathers leaf extract, candlenut tree seed oil, alfalfa extract, marine alga extraction brown alga
Acid, ATRA, apricot kernel oil, aloe extraction liquid, alpha-glucans oligosaccharide, Hawaii drupe oil, alpha-lipoic acid, α-fertility
Phenol, deep-sea yeast extract, bluish-green algae extract, pineapple extract, bitter oil tree oil, camomile extract, Benzoinum extract,
Streptococcus acidi lactici fermented solution, Bifidobacterium extract, Bilberry fruit P.E, extraction from betula plaryphylla, birch leaf extract, bisabolol,
Bladder-wrack extract, carbomer, cetostearyl alcohol, list haw thorn extract, creatine, creatinine, Fructus Cucumidis sativi extract, the extraction of muskmelon fruit
Thing, glucose tyrosine, glutamic acid, glutamine, glutathione, Irish moss extract, lauroyl lysine, Bai Manghua seeds
One or more in oil, methionine, Glucate SS.
A kind of basic aqua described above, comprising anti-inflammatory component, the anti-inflammatory component is sweet including at least copaiba fatty oil, ocean
Chrysanthemum extract, Common Borage seed oil, decarboxylation carnosine hydrochloric acid, evening primrose oil, evodia extract extract, burdock extract, L- resist
Bad hematic acid, edelweiss extract, licorice, radix glycyrrhizae linoleic acid, nettle extract, niacinamide, Quercetin, red clover
One or more in grass, resveratrol, ubiquinone, Cortex ulmi pumilae extract, heartsease extract, Zingiber zerumbet extract.Above-mentioned
Anti-inflammatory component is added in basic aqua to be helped to eliminate skin inflammation, hypo-allergenic.
A kind of preparation method for including above-described basic aqua, it is characterised in that comprise the steps of：
(1) a certain amount of rank mineral water of drinking is taken to be placed in clean beaker on magnetic stirring apparatus；
(2) rhamnolipid 5-50mg/L is slowly added to while stirring, to homogeneous system；
(3) be then slowly added into active VC 0.1-1g/L, hyaluronic acid 5-20mg/L, and a certain amount of carrier components and
Anti-inflammatory component, finally supply surplus and drink rank mineral water, continue to stir 10-20min；
(4) by obtained liquid with 0.22 μm of filtering with microporous membrane, the high borosilicate green and environment-friendlyglass glass being sub-packed in after sterilizing
In dropper allotment bottle, the basic aqua containing rhamnolipid is made.
Preferably, the rotating speed of the magnetic stirring apparatus is 100-500rpm.
Rhamnolipid has self-corrosion protection function, it is not necessary to adds preservative again.Rhamnolipid belongs to small-molecule substance, can be with
Skin permeation epidermis reaches skin corium, is attached on the fibroblast for producing collagen, participates in blood circulation, the blood of enhancing
Flow adds the blood circulation in capilary, have stimulated the quick movement of cell, makes these cells with than fast faster in the past
Degree propagation, adds the structure and tensile strength of deep skin, makes the wrinkle of skin surface smoothened, reduce going out for wrinkle
It is existing.The CBF of this enhancing can also eliminate any stimulation and the inflammation near infected area.
Hyaluronic acid is the material that moisture retention is best in the nature having now been found that, be referred to as preferable natural moisture preserving because
Son.It can improve skin-nourishing metabolism, make skin it is tender, it is smooth, go to wrinkle, increase it is elastic, prevent aging, while moisturizing
It is good skin penetration enhancer again.Used with components matchings such as rhamnolipid, active VC, anti-inflammatory component, carrier components, can
To play the more preferable effect for promoting it to absorb.Hyaluronic acid also has the function that epidermal tissue repairs, and helps and is recovering skin just
Normal oil-water balance, improve skin of drying and relax.
Beneficial effects of the present invention：
1st, basic aqua of the present invention, which has, promotes fibroblast growth rate, accelerates the work(of collagen generation
Effect, the structure and tensile strength of deep skin are added, the effect of reaching smooth out wrinkles.Inherently solves external source/people source
The problem of collagen absorption.
2nd, basic aqua of the present invention has the effect of efficient moisture-retention, regulation skin water and oil balance.
3rd, basic aqua of the present invention has anti-inflammatory, antianaphylactic effect, and small pox flesh and sensitive skin can make
With tool has been widely used.
4th, preservative free in basic aqua of the present invention, solves the problems, such as the bad skin that preservative is brought.
5 basic aqua techniques of the present invention are simple, and stability is high.It can be used alone, can also be used as a substrate,
Addition other compositions are used cooperatively, and are had a wide range of application.
Brief description of the drawings
Fig. 1 is 95% purity rhamnolipid Mass Spectrometer Method result figure in embodiment；
Fig. 2 is 98% purity rhamnolipid Mass Spectrometer Method result figure in embodiment.
Embodiment
The present invention is described further with reference to embodiments, but is not intended to limit the scope of the present invention.
Embodiment one：
(1) a certain amount of rank mineral water of drinking is taken to be placed in clean beaker on magnetic stirring apparatus, adjustment rotating speed is
100rpm；
(2) rhamnolipid 5mg/L is slowly added to while stirring, to homogeneous system；
(3) be then slowly added into active VC 0.1g/L, hyaluronic acid 5mg/L, and a certain amount of carrier components and anti-inflammatory into
Point, finally supply surplus and drink rank mineral water, continue to stir 20min；
(4) by obtained liquid with 0.22 μm of filtering with microporous membrane, the high borosilicate green and environment-friendlyglass glass being sub-packed in after sterilizing
In dropper allotment bottle, the basic aqua containing rhamnolipid is made.
The rhamnolipid content of this embodiment is 5mg/L, and active VC contents are 0.1g/L, hyaluronic acid contents 5mg/
L, the active VC are L-vitamin C, and the anti-inflammatory component is camomile extract, and the carrier components are glutamine.
Embodiment two：
(1) take a certain amount of rank mineral water of drinking to be placed in clean beaker on magnetic stirring apparatus, adjust rotating speed
250rpm；
(2) rhamnolipid is slowly added to while stirring, to homogeneous system；
(3) active VC, hyaluronic acid, and a certain amount of carrier components and anti-inflammatory component are then slowly added into, is finally supplied
Surplus drinks rank mineral water, continues to stir 20min；
(4) by obtained liquid with 0.22 μm of filtering with microporous membrane, the high borosilicate green and environment-friendlyglass glass being sub-packed in after sterilizing
In dropper allotment bottle, the basic aqua containing rhamnolipid is made.
The rhamnolipid content of this embodiment is 25mg/L, and active VC contents are 1g/L, hyaluronic acid contents 15mg/
L.The active VC is L-vitamin C, VC-IP and COS-VCE, and the anti-inflammatory component is camomile extract, high mountain tinder
Careless extract and evening primrose oil, the carrier components are glutamine, 1,2- hexylene glycols and atriphos.
Embodiment three：
(1) take a certain amount of rank mineral water of drinking to be placed in clean beaker on magnetic stirring apparatus, adjust rotating speed
500rpm；
(2) rhamnolipid is slowly added to while stirring, to homogeneous system；
(3) active VC, hyaluronic acid, and a certain amount of carrier components and anti-inflammatory component are then slowly added into, is finally supplied
Surplus drinks rank mineral water, continues to stir 20min；
(4) by obtained liquid with 0.22 μm of filtering with microporous membrane, the high borosilicate green and environment-friendlyglass glass being sub-packed in after sterilizing
In dropper allotment bottle, the basic aqua containing rhamnolipid is made.
The rhamnolipid content of this embodiment is 25mg/L, and active VC contents are 0.5g/L, hyaluronic acid contents are
15mg/L。
The active VC is L-vitamin C, AA2G, VC-IP, COS-VCE, lemon extract, anthocyanidin carry
Take thing, the stingless rose extract of malpighia glabra extract and Japan.
The anti-inflammatory component is copaiba fatty oil, camomile extract, Common Borage seed oil, decarboxylation carnosine hydrochloric acid, oenothera biennis
Oil, evodia extract extract, burdock extract, L-AA, edelweiss extract, licorice, radix glycyrrhizae
Linoleic acid, nettle extract, niacinamide, Quercetin, red clover, resveratrol, ubiquinone, Cortex ulmi pumilae extract, heartsease
Extract, Zingiber zerumbet extract.
The carrier components are 1,2- hexylene glycols, 10- hydroxydecanoic acids, gum arabic, acai berry extract, acetyl meat poisoning
Alkali salt acid, acetylglucosamine, acetoglyceride ricinoleate, acetyl hexapeptide, acetyl tributyl citric acid, acetyl junket ammonia
Acid, acetylated castor oil, acetylated hydrogenated cottonseed glycerine, acetylated lanolin, acetulan, acetylation palm kernel are sweet
Grease, acetylsalicylic acid, acrylate, acrylate copolymer, adenylate, adenine, atriphos, White mushroom extraction
Thing, Agrimonia eupatoria leaf extract, beautiful Yi Gucao extracts, Xinjiang Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) extract, albumin, the extraction of garment or robe made of feathers blade of grass
Thing, candlenut tree seed oil, alfalfa extract, marine alga extraction alginic acid, ATRA, apricot kernel oil, aloe extraction liquid, α-Portugal
Glycan oligosaccharide, Hawaii drupe oil, alpha-lipoic acid, alpha-tocopherol, deep-sea yeast extract, bluish-green algae extract, pineapple carry
Take thing, bitter oil tree oil, camomile extract, Benzoinum extract, streptococcus acidi lactici fermented solution, Bifidobacterium extract, cowberry extraction
Thing, extraction from betula plaryphylla, birch leaf extract, bisabolol, bladder-wrack extract, carbomer, cetostearyl alcohol, list mountain
Short, bristly hair or beard extract, creatine, creatinine, Fructus Cucumidis sativi extract, muskmelon berry extract, glucose tyrosine, glutamic acid, glutamine, paddy Guang
Sweet peptide, Irish moss extract, lauroyl lysine, white awns flower seed oil, methionine, Glucate SS.
Example IV：
The making step of this embodiment is identical with embodiment three, and difference is aqua content, and rhamnolipid content is 50mg/
L, active VC contents are 1g/L, hyaluronic acid contents 20mg/L.
Rhamnolipid (manufacturer described in above-described embodiment：Xi'an Rege Biotech. Co., Ltd.) purity is
98.0-99.9%, it is Rha-Rha-C10-C10 through Mass Spectrometer Method structure, white is natural to slightly yellow liquid or freeze-dried powder
Fermentation activity product, do not have any toxicity to human body.
It is described drink rank mineral water and refer to be less than rich in the human body beneficial mineral matter element such as strontium, zinc, selenium, total dissolved solid
280ppm pure water.
Rhamnolipid method for detecting purity：Impurity removal method
Formula：Rhamnolipid purity=100%- albumen %- nucleic acid %- water-insolubles %
Wherein：Protein content is detected using Kjeldahl's method, and nucleic acid content is detected using ultraviolet spectrophotometry, and water is insoluble
Thing is using difference weight method detection.
According to the method, detection obtains：Rhamnolipid 1, purity 80%；Rhamnolipid 2, purity 95%；Rhamnolipid 3,
Purity 98%；
Then purity checking is carried out using soft ionization mass spectrum：The use of matrix is 2,5 one dihydroxy-benzoic acids, control software is
Flex Control, analysis software are flex Analysis versison3.3, using nitrogen lasers, wavelength 337nm, bear from
Subpattern.Use instrument：MALDI-TOF MS (Ultrafle Xtreme, Bruker Dahonics, USA)
Collagen content detection method：
Biocolor biochemistry detection aquas box (Sircol Collagen Assay Family:Insoluble&Soluble
Collagen), detection sensitivity：1.0μg.
The effect that different purity rhamnolipid generates to collagen
Rhamnolipid 1,2,3 is configured to 5-50mg/L solution respectively, mouse skin is smeared, mouse is extracted after a period of time
Collagen in skin histology, collagen content is detected, is as a result found：1. in skin histology, reach similar collagen
Content, the frequency of use of rhamnolipid 1, which compares rhamnolipid 2,3, to be needed to improve to 3-5 times；The wherein use frequency of rhamnolipid 3
Rate is minimum.2. in skin histology, reaching similar collagen content, the usage time of rhamnolipid 1 needs to extend 3-8 weeks；
Wherein, the usage time of rhamnolipid 3 is most short.
Conclusion：The rhamnolipid of more than 98% high-purity is more suitable for this case.
Remove wrinkle, anti-aging benchmark test：
By the basic aqua of the glycolipid containing high-purity rhamnazin of preparation, contrast test is carried out with pure water (CK).
(1) Evaluation
Above-mentioned sample is smeared into mouse skin respectively, collagen in mice skin tissue, detection are extracted after a period of time
Collagen content, as a result show, collagen content is CK in skin after the basic aqua effect of the glycolipid containing high-purity rhamnazin
4 times of collagen content in control group skin.
(2) human body is evaluated
Above-mentioned sample is sprayed into face respectively, investigates skin colourity, humidity, acid-base value, glossiness, roughness, grease point
The change of the physical and chemical index such as the amount of secreting, water content, elasticity, skin and stratum corneum lipids, wrinkle quantity, length and the depth and overall target
Change, use the influence of the front and rear feature to skin senescence each side by 3 kinds of samples more than relatively, objective evaluation go wrinkle,
Anti-aging performance.
As a result show, after 3 weeks, the basic aqua of the glycolipid containing high-purity rhamnazin is to skin physical and chemical index and overall target
Having significantly improves.
Conclusion (of pressure testing)：The basic aqua of the glycolipid containing high-purity rhamnazin can reach skin corium with skin permeation epidermis, participate in blood
Liquid circulates, and promotes fibroblast growth rate, accelerates collagen to generate, and structure and the tension for adding deep skin are strong
Degree.
Described above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-mentioned implementation
Example.All technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It is noted that for the art
Those of ordinary skill for, improvements and modifications under the premise without departing from the principles of the invention, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of basic aqua, it is characterised in that include rhamnolipid and hyaluronic acid.
2. basic aqua according to claim 1, it is characterised in that the rhamnolipid content is 5-50mg/L, described
Rhamnolipid is 98.0-99.9% high-purity rhamnazin glycolipids.
3. basic aqua according to claim 1, it is characterised in that the hyaluronic acid contents are 5-20mg/L.
4. basic aqua according to claim 1, it is characterised in that comprising active VC, the active VC gives birth to for left-handed dimension
Plain C, AA2G, VC-IP, COS-VCE, lemon extract, cyanidin extract, malpighia glabra extract, Japanese nothing
The one or more pierced in rose extract.
5. basic aqua according to claim 4, it is characterised in that the active VC contents are 0.1-1g/L.
6. basic aqua according to claim 1, it is characterised in that comprising preparation water, the preparation water is to drink
Rank mineral water；The rank mineral water of drinking refers to rich in strontium, zinc and selenium, pure water of the total dissolved solid less than 280ppm.
7. basic aqua according to claim 1, it is characterised in that comprising carrier components, the carrier components at least wrap
Hexylene glycol containing 1,2-, 10- hydroxydecanoic acids, gum arabic, acai berry extract, acetylcarnitine hydrochloric acid, acetamido glucose
Sugar, acetoglyceride ricinoleate, acetyl hexapeptide, acetyl tributyl citric acid, Acetyl Tyrosine, acetylated castor oil, acetyl
Change hydrogenated cotton seeds glycerine, acetylated lanolin, acetulan, acetylation palm kernel glycerides, acetylsalicylic acid, propylene
Acid esters, acrylate copolymer, adenylate, adenine, atriphos, White mushroom extract, Agrimonia eupatoria leaf extract,
Beautiful Yi Gucao extracts, Xinjiang Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) extract, albumin, garment or robe made of feathers leaf extract, candlenut tree seed oil, alfalfa extraction
Thing, marine alga extraction alginic acid, ATRA, apricot kernel oil, aloe extraction liquid, alpha-glucans oligosaccharide, Hawaii drupe oil,
Alpha-lipoic acid, alpha-tocopherol, deep-sea yeast extract, bluish-green algae extract, pineapple extract, bitter oil tree oil, chamomile extraction
Thing, Benzoinum extract, streptococcus acidi lactici fermented solution, Bifidobacterium extract, Bilberry fruit P.E, extraction from betula plaryphylla, birch leaf
Extract, bisabolol, bladder-wrack extract, carbomer, cetostearyl alcohol, list haw thorn extract, creatine, creatinine, cucumber
Extract, muskmelon berry extract, glucose tyrosine, glutamic acid, glutamine, glutathione, Irish moss extract, bay
One or more in acyl lysine, white awns flower seed oil, methionine, Glucate SS.
8. basic aqua according to claim 1, it is characterised in that comprising anti-inflammatory component, the anti-inflammatory component at least wraps
Fatty oil containing copaiba, camomile extract, Common Borage seed oil, the extraction of decarboxylation carnosine hydrochloric acid, evening primrose oil, evodia extract
Thing, burdock extract, L-AA, edelweiss extract, licorice, radix glycyrrhizae linoleic acid, nettle extract, cigarette
In acid amides, Quercetin, red clover, resveratrol, ubiquinone, Cortex ulmi pumilae extract, heartsease extract, Zingiber zerumbet extract
It is one or more.
9. the preparation method of a kind of basic aqua as described in claim 1-8 is any, it is characterised in that comprise the steps of：
(1) a certain amount of rank mineral water of drinking is taken to be placed in clean beaker on magnetic stirring apparatus；
(2) rhamnolipid 5-50mg/L is slowly added to while stirring, to homogeneous system；
(3) active VC 0.1-1g/L, hyaluronic acid 5-20mg/L, and a certain amount of carrier components and anti-inflammatory are then slowly added into
Composition, finally supply surplus and drink rank mineral water, continue to stir 10-20min；
(4) by obtained liquid with 0.22 μm of filtering with microporous membrane, the high borosilicate green and environment-friendlyglass glass dropper being sub-packed in after sterilizing
Allocate in bottle, the basic aqua containing rhamnolipid is made.
10. a kind of preparation method of basic aqua as claimed in claim 9, it is characterised in that the magnetic stirring apparatus turns
Speed is 100-500rpm.
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| CN108498385A (en) * | 2018-04-28 | 2018-09-07 | 广州赛莱拉干细胞科技股份有限公司 | Composition containing Codium Tomentosum extract and its application in cosmetics |
| CN114917155A (en) * | 2022-05-11 | 2022-08-19 | 广州天玺生物科技有限公司 | Centella asiatica-containing composition suitable for repairing sensitive muscles and application thereof |
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| CN1582894A (en) * | 2004-06-02 | 2005-02-23 | 云南省天然药物中心 | Serial cosmetic compositions with Yuganzi as primary activating component |
| US20130287708A1 (en) * | 2010-12-09 | 2013-10-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Natural formulations |
| WO2015030702A2 (en) * | 2013-08-26 | 2015-03-05 | Keith Desanto | High purity rhamnolipid cosmetic application |
| CN103976930A (en) * | 2014-05-13 | 2014-08-13 | 王赫 | Anti-glycation whitening cream |
| CN104789519A (en) * | 2015-04-29 | 2015-07-22 | 浙江传化生物技术有限公司 | Culture medium for in vitro fast growth of dendrobium officinale |
| CN104887589A (en) * | 2015-06-23 | 2015-09-09 | 中国热带农业科学院农产品加工研究所 | Whitening and moisturizing body cream and preparation method thereof |
| CN105232432A (en) * | 2015-11-18 | 2016-01-13 | 李爱冰 | Traditional Chinese medicine bath cream and preparation method thereof |
| CN105816358A (en) * | 2016-04-05 | 2016-08-03 | 珠海市法维亚生物科技有限公司 | Moisturizing anti-ageing skin care product containing crocodile oil |
| CN106309246A (en) * | 2016-10-10 | 2017-01-11 | 大连苗谣青颜生物科技有限公司 | Multieffect skin-smoothing cream and preparation method thereof |
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