CN111184670A - Cosmetic emulsion containing nanogold component and preparation method thereof - Google Patents
Cosmetic emulsion containing nanogold component and preparation method thereof Download PDFInfo
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- CN111184670A CN111184670A CN202010155197.1A CN202010155197A CN111184670A CN 111184670 A CN111184670 A CN 111184670A CN 202010155197 A CN202010155197 A CN 202010155197A CN 111184670 A CN111184670 A CN 111184670A
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- 239000008271 cosmetic emulsion Substances 0.000 title claims abstract description 11
- 238000002360 preparation method Methods 0.000 title description 7
- 239000010931 gold Substances 0.000 claims abstract description 41
- 229910052737 gold Inorganic materials 0.000 claims abstract description 26
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000006243 chemical reaction Methods 0.000 claims abstract description 15
- 239000000243 solution Substances 0.000 claims description 33
- 239000000839 emulsion Substances 0.000 claims description 26
- 239000000419 plant extract Substances 0.000 claims description 17
- 241000220317 Rosa Species 0.000 claims description 15
- 238000001027 hydrothermal synthesis Methods 0.000 claims description 15
- 239000000341 volatile oil Substances 0.000 claims description 15
- 239000008367 deionised water Substances 0.000 claims description 14
- 229910021641 deionized water Inorganic materials 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 10
- 229920001661 Chitosan Polymers 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 10
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 10
- 229920002674 hyaluronan Polymers 0.000 claims description 10
- 229960003160 hyaluronic acid Drugs 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 9
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 6
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 229940087603 grape seed extract Drugs 0.000 claims description 5
- 235000002532 grape seed extract Nutrition 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000010008 shearing Methods 0.000 claims description 5
- 239000001509 sodium citrate Substances 0.000 claims description 5
- 238000009210 therapy by ultrasound Methods 0.000 claims description 5
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 5
- 229940038773 trisodium citrate Drugs 0.000 claims description 5
- 239000001717 vitis vinifera seed extract Substances 0.000 claims description 5
- 238000003760 magnetic stirring Methods 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 3
- 229940119217 chamomile extract Drugs 0.000 claims description 2
- 235000020221 chamomile extract Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 abstract description 8
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 230000003020 moisturizing effect Effects 0.000 abstract description 3
- 230000003712 anti-aging effect Effects 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 210000001339 epidermal cell Anatomy 0.000 abstract description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 2
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000010899 nucleation Methods 0.000 abstract 1
- 230000006911 nucleation Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 7
- 239000011259 mixed solution Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 241000533950 Leucojum Species 0.000 description 4
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 235000017471 coenzyme Q10 Nutrition 0.000 description 3
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 3
- 229940110767 coenzyme Q10 Drugs 0.000 description 3
- -1 hydroxyl radicals Chemical class 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 238000000026 X-ray photoelectron spectrum Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The cosmetic emulsion provided by the invention combines the snowflake-shaped nanogold with the moisturizing component and the antibacterial and anti-inflammatory component, wherein the nanogold has a good antioxidant function, can effectively remove hydroxyl free radicals to promote human epidermal cell proliferation and has an anti-aging function, the thermal and kinetic factors of the reaction are controlled under a sealed hydrothermal condition in a dynamic nucleation and crystallization mode, and finally the snowflake-shaped Au nanoparticles are obtained, and the snowflake-shaped nanogold-shaped gold has more surface step atoms and high active site density and can effectively reduce the cost.
Description
Technical Field
The invention relates to the field of daily fine chemical products, in particular to a cosmetic emulsion containing a nano-gold component.
Background
With the development of society and the continuous improvement of living standard of people, the cosmetic industry in China is in the rapid development period, and meanwhile, the continuous research and development of cosmetic types are promoted to meet the needs of people. The cosmetics can be further divided into different types of cosmetics for infants, cosmetics for juveniles, cosmetics for men, cosmetics for pregnant women and the like according to objects, and are mainly divided into cosmetic varieties with different effects of whitening, moisturizing, wrinkle resistance, aging resistance and the like according to purposes.
Electronic equipment in daily life is used more and more frequently, skin is known to be exposed to blue light and high-energy environment for a long time to accelerate skin aging and wrinkle growth, until now, coenzyme Q10 which is a main component of antioxidation basically plays a role once, namely, the coenzyme Q10 loses efficacy once entering the body and has 7 active oxygen, and the coenzyme Q10 and other components can only remove one active oxygen, so that some research and development personnel apply nanogold to cosmetics, can enter the deep layer of the skin, can not only activate cells, but also eliminate free radicals and resist oxidation, however, the addition of gold can cause the cost of the cosmetics to be increased.
The shape of the nano Au is an important factor influencing the physicochemical property of the Au, the Au is prepared into nano particles, the proportion of surface atoms is greatly improved, the specific surface area is greatly increased, and the distribution and arrangement of the Au surface atoms with different shapes are different. Therefore, by using the shape control synthesis technology, the Au nano material with a specific shape can be prepared by a simple method and applied to cosmetics to improve the utilization efficiency of the nano gold and reduce the cost of the emulsion, and the method has important application value and practical significance.
Disclosure of Invention
Based on the consideration, the technical problem to be solved by the invention is to provide a cosmetic emulsion containing nanogold, which improves the utilization efficiency of Au nanoparticles by changing the shape of the Au nanoparticles, reduces the use amount of Au and reduces the cost.
The invention relates to a preparation method of a cosmetic emulsion containing nanogold, which comprises the following steps:
(1) preparing a hyaluronic acid aqueous solution, adding the prepared nano gold sol, and performing ultrasonic treatment until the solution is uniform to obtain a solution A;
(2) adding a certain amount of plant extract and rose essential oil into deionized water, and stirring until the plant extract and the rose essential oil are completely dissolved to obtain a solution B;
(3) adding chitosan into butanediol and ethylhexylglycerin, and uniformly mixing to obtain a solution C;
(4) preparing emulsion by a microfluidic technology, respectively injecting the solution A, B, C into the first flow channel, the second flow channel and the third flow channel, and fully colliding and shearing media in the flow channels at the intersection of the flow channels to obtain the emulsion.
Preferably, the mass concentration of the added nano gold is 0.01-0.05% and the mass concentration of the added hyaluronic acid is 0.3-1% based on the prepared emulsion.
Preferably, the mass concentration of the added plant extract is 2-8% and the mass concentration of the added rose essential oil is 1-3% based on the prepared emulsion.
Preferably, based on the emulsion obtained, the addition mass concentration of chitosan is 0.5% -2%, the addition mass concentration of butanediol is 5% -10%, and the addition mass concentration of ethylhexyl glycerol is 5% -10%.
Preferably, the plant extract is selected from grape seed extract and/or chamomile extract.
Preferably, the preparation steps of the nanogold sol are as follows:
A. weighing 60mg of PVP, 180mg of trisodium citrate (Na3C6HSO7) and 30mg of NaBr in a 20ml hydrothermal reaction kettle;
B. adding 0.6g of 20mM NaAuCl4 aqueous solution into a hydrothermal reaction kettle, measuring 8ml of deionized water into the hydrothermal reaction kettle, and magnetically stirring for 15min at room temperature;
C. and C, heating the reaction kettle in the step B to 160 ℃ by a program, reacting the reaction solution for 6 hours at a constant temperature under a magnetic stirring state of 800r/min, finishing the reaction, and cooling to room temperature to obtain the snowflake-shaped nanogold sol.
The invention has the beneficial effects that: the cosmetic emulsion provided by the invention combines the snowflake-shaped nanogold with the moisturizing component and the antibacterial and anti-inflammatory component, wherein the nanogold has a good antioxidant function, can effectively remove hydroxyl free radicals to promote the proliferation of epidermal cells of a human body and has an anti-aging function, the snowflake-shaped nanogold-shaped gold has more surface step atoms, the active site density is high, and the cost can be effectively reduced.
Drawings
FIG. 1 is an XRD spectrum of snowflake Au nanoparticles prepared;
FIG. 2 is an XPS spectrum of snowflake Au nanoparticles prepared in example 1;
FIG. 3 is a TEM spectrum of Au nanoparticles prepared in comparative example 1;
fig. 4 is a TEM spectrum of Au nanoparticles prepared in comparative example 2.
Detailed Description
The following detailed description is made with reference to the accompanying drawings.
Example 1
A method for preparing cosmetic emulsion containing nanogold comprises the following steps:
(1) preparing a hyaluronic acid aqueous solution, adding the prepared nano gold sol, and performing ultrasonic treatment until the solution is uniform to obtain a solution A;
(2) adding a certain amount of plant extract and rose essential oil into deionized water, and stirring until the plant extract and the rose essential oil are completely dissolved to obtain a solution B;
(3) adding chitosan into butanediol and ethylhexylglycerin, and uniformly mixing to obtain a solution C;
(4) preparing emulsion by a microfluidic technology, respectively injecting the solution A, B, C into the first flow channel, the second flow channel and the third flow channel, and fully colliding and shearing media in the flow channels at the intersection of the flow channels to obtain the emulsion.
Based on the prepared emulsion, the adding mass concentration of the nano gold is 0.02%, and the adding mass concentration of the hyaluronic acid is 0.8%.
Based on the prepared emulsion, the adding mass concentration of the plant extract is 7%, and the adding mass concentration of the rose essential oil is 2%.
Based on the prepared emulsion, the adding mass concentration of the chitosan is 1%, the adding mass concentration of the butanediol is 9%, and the adding mass concentration of the ethylhexyl glycerin is 5%.
The plant extractive solution is selected from grape seed extract.
The preparation steps of the nano gold sol are as follows:
A. weighing 60mg of PVP, 180mg of trisodium citrate (Na3C6HSO7) and 30mg of NaBr in a 20ml hydrothermal reaction kettle;
B. adding 0.6g of 20mM NaAuCl4 aqueous solution into a hydrothermal reaction kettle, measuring 8ml of deionized water into the hydrothermal reaction kettle, and magnetically stirring for 15min at room temperature;
C. and (3) heating the reaction kettle in the step (B) to 160 ℃, reacting the reaction solution for 6 hours at constant temperature under the magnetic stirring state of 800r/min, finishing the reaction, and cooling to room temperature to obtain snowflake-shaped nanogold (shown in figure 1) sol.
Comparative example 1
A method for preparing cosmetic emulsion containing nanogold comprises the following steps:
(1) preparing a hyaluronic acid aqueous solution, adding the prepared nano gold sol, and performing ultrasonic treatment until the solution is uniform to obtain a solution A;
(2) adding a certain amount of plant extract and rose essential oil into deionized water, and stirring until the plant extract and the rose essential oil are completely dissolved to obtain a solution B;
(3) adding chitosan into butanediol and ethylhexylglycerin, and uniformly mixing to obtain a solution C;
(4) preparing emulsion by a microfluidic technology, respectively injecting the solution A, B, C into the first flow channel, the second flow channel and the third flow channel, and fully colliding and shearing media in the flow channels at the intersection of the flow channels to obtain the emulsion.
Based on the prepared emulsion, the adding mass concentration of the nano gold is 0.02%, and the adding mass concentration of the hyaluronic acid is 0.8%.
Based on the prepared emulsion, the adding mass concentration of the plant extract is 7%, and the adding mass concentration of the rose essential oil is 2%.
Based on the prepared emulsion, the adding mass concentration of the chitosan is 1%, the adding mass concentration of the butanediol is 9%, and the adding mass concentration of the ethylhexyl glycerin is 5%.
The plant extractive solution is selected from grape seed extract.
The preparation steps of the nano gold sol are as follows:
A. 60mg PVP, 180mg trisodium citrate (Na) are weighed out3C6HSO7) In a 20ml hydrothermal reaction kettle;
B. 0.6g of 20mM NaAuCl was added4Adding the aqueous solution into a hydrothermal reaction kettle, then measuring 8ml of deionized water into the hydrothermal reaction kettle, and placing the kettle in a roomMagnetically stirring for 15min at room temperature;
C. and C, heating the reaction kettle in the step B to 160 ℃ by a program, reacting the reaction solution for 6 hours at a constant temperature under a magnetic stirring state of 800r/min, finishing the reaction, and cooling to room temperature to obtain Au nano (shown in figure 3) sol.
Comparative example 2
A method for preparing cosmetic emulsion containing nanogold comprises the following steps:
(1) preparing a hyaluronic acid aqueous solution, adding the prepared nano gold sol, and performing ultrasonic treatment until the solution is uniform to obtain a solution A;
(2) adding a certain amount of plant extract and rose essential oil into deionized water, and stirring until the plant extract and the rose essential oil are completely dissolved to obtain a solution B;
(3) adding chitosan into butanediol and ethylhexylglycerin, and uniformly mixing to obtain a solution C;
(4) preparing emulsion by a microfluidic technology, respectively injecting the solution A, B, C into the first flow channel, the second flow channel and the third flow channel, and fully colliding and shearing media in the flow channels at the intersection of the flow channels to obtain the emulsion.
Based on the prepared emulsion, the adding mass concentration of the nano gold is 0.02%, and the adding mass concentration of the hyaluronic acid is 0.8%.
Based on the prepared emulsion, the adding mass concentration of the plant extract is 7%, and the adding mass concentration of the rose essential oil is 2%.
Based on the prepared emulsion, the adding mass concentration of the chitosan is 1%, the adding mass concentration of the butanediol is 9%, and the adding mass concentration of the ethylhexyl glycerin is 5%.
The plant extractive solution is selected from grape seed extract.
The preparation steps of the nano gold sol are as follows:
A. 60mg PVP, 180mg trisodium citrate (Na) are weighed out3C6HSO7) And 30mgNaBr in a 20ml hydrothermal reaction kettle;
B. 0.6g of 20mM NaAuCl was added4Putting the aqueous solution into a hydrothermal reaction kettle, then measuring 8ml of deionized water into the hydrothermal reaction kettle, and magnetically stirring for 15min at room temperature;
C. and C, heating the reaction kettle in the step B to 160 ℃ by a program, reacting for 6 hours at a constant temperature, finishing the reaction, and cooling to room temperature to obtain Au nano (shown in figure 4) sol.
Hydroxyl radical scavenging activity test method: antioxidant activity is expressed in terms of the ability to scavenge hydroxyl radicals. 1. After the nano gold colloids of example 1 and comparative examples 1 and 2 are respectively washed by centrifugation, 20mL of mixed solution of ethanol and deionized water (volume ratio of 1:1) is dispersed to prepare gold sols with the same concentration, and then 10mL of 2M salicylic acid and 17mL of 2M FeSO are added into a beaker to be uniformly mixed4Mixing the solution, adding 0.6mL of H with the mass concentration of 0.03%2O2Shaking up and keeping the temperature at 40 ℃ for 25min, and measuring the absorbance Am of the sample group at 510 nm; 2. taking the mixed solution (volume ratio is 1:1) of ethanol and deionized water after centrifugal washing of the nano gold colloids of example 1 and comparative examples 1 and 2 respectively, dispersing and preparing 20mL of gold sol with the same concentration, adding the mixed solution into 10mL of 2M salicylic acid and 17mL of 2M FeSO4 mixed solution which are uniformly mixed in a beaker, then adding 0.6mL of deionized water, shaking uniformly, keeping the temperature at 40 ℃ for 25min, and measuring the absorbance An of a sample group at 510 nm; 3. taking 20mL of mixed solution of ethanol and deionized water (the volume ratio is 1:1), adding 10mL of mixed solution of 2M salicylic acid and 17mL of mixed solution of 2M FeSO4 which are uniformly mixed in a beaker, and then adding 0.6mL of H with the mass concentration of 0.03 percent2O2Shaking and keeping the temperature at 40 ℃ for 25min, and measuring the absorbance A of the sample group at 510nm0. Each of the above three groups was repeated 3 times, and the average value was determined. The clearance was calculated as follows: OH clearance (%) ═ A0-(Am-An)]/A0The x is 100 percent, the clearance rate of the snowflake gold to the hydroxyl free radical in the embodiment 1 is 65.6 percent, the clearance rate of the gold to the hydroxyl free radical in the comparative examples 1 and 2 is 38.4 percent and 31.2 percent, the test result shows that the shapes of the nano-gold are different in oxidation resistance, and the snowflake nano-gold has higher and more effective oxidation resistance effect on the common-shape nano-gold.
Claims (6)
1. A method for preparing cosmetic emulsion containing nanogold comprises the following steps:
(1) preparing a hyaluronic acid aqueous solution, adding the prepared nano gold sol, and performing ultrasonic treatment until the solution is uniform to obtain a solution A;
(2) adding a certain amount of plant extract and rose essential oil into deionized water, and stirring until the plant extract and the rose essential oil are completely dissolved to obtain a solution B;
(3) adding chitosan into butanediol and ethylhexylglycerin, and uniformly mixing to obtain a solution C;
(4) preparing emulsion by a microfluidic technology, respectively injecting the solution A, B, C into the first flow channel, the second flow channel and the third flow channel, and fully colliding and shearing media in the flow channels at the intersection of the flow channels to obtain the emulsion.
2. The production method according to claim 1, wherein the nanogold is added in a mass concentration of 0.01 to 0.05% and the hyaluronic acid is added in a mass concentration of 0.3 to 1% based on the emulsion obtained.
3. The method according to claim 1, wherein the plant extract is added in a mass concentration of 2 to 8% and the rose essential oil is added in a mass concentration of 1 to 3% based on the emulsion obtained.
4. The process according to claim 1, wherein the chitosan is added in a mass concentration of 0.5 to 2%, the butanediol is added in a mass concentration of 5 to 10%, and the ethylhexylglycerin is added in a mass concentration of 5 to 10%, based on the emulsion obtained.
5. The method according to claim 1, wherein the plant extract is selected from the group consisting of a grape seed extract and a chamomile extract.
6. The method according to claim 1, wherein the nanogold sol is prepared by the following steps:
A. weighing 60mg of PVP, 180mg of trisodium citrate (Na3C6HSO7) and 30mg of NaBr in a 20ml hydrothermal reaction kettle;
B. adding 0.6g of 20mM NaAuCl4 aqueous solution into a hydrothermal reaction kettle, measuring 8ml of deionized water into the hydrothermal reaction kettle, and magnetically stirring for 15min at room temperature;
C. and C, heating the reaction kettle in the step B to 160 ℃ by a program, reacting the reaction solution for 6 hours at a constant temperature under a magnetic stirring state of 800r/min, finishing the reaction, and cooling to room temperature to obtain the snowflake-shaped nanogold sol.
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