CN117653559A - Colloidal platinum mask formula and preparation method and application thereof - Google Patents
Colloidal platinum mask formula and preparation method and application thereof Download PDFInfo
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- CN117653559A CN117653559A CN202211008206.XA CN202211008206A CN117653559A CN 117653559 A CN117653559 A CN 117653559A CN 202211008206 A CN202211008206 A CN 202211008206A CN 117653559 A CN117653559 A CN 117653559A
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- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims abstract description 70
- 229910052697 platinum Inorganic materials 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000009472 formulation Methods 0.000 title claims description 11
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 45
- 239000006185 dispersion Substances 0.000 claims abstract description 25
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 22
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 11
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 11
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 11
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 11
- 239000011718 vitamin C Substances 0.000 claims abstract description 11
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 11
- 229940046009 vitamin E Drugs 0.000 claims abstract description 11
- 239000011709 vitamin E Substances 0.000 claims abstract description 11
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims abstract description 9
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000835 fiber Substances 0.000 claims abstract description 8
- 239000003906 humectant Substances 0.000 claims abstract description 7
- 239000000419 plant extract Substances 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004472 Lysine Substances 0.000 claims abstract description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000032683 aging Effects 0.000 claims abstract description 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000018417 cysteine Nutrition 0.000 claims abstract description 6
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 6
- 239000011591 potassium Substances 0.000 claims abstract description 6
- 229920000742 Cotton Polymers 0.000 claims abstract description 4
- 229920002522 Wood fibre Polymers 0.000 claims abstract description 4
- QKSIFUGZHOUETI-UHFFFAOYSA-N copper;azane Chemical compound N.N.N.N.[Cu+2] QKSIFUGZHOUETI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 4
- 239000002025 wood fiber Substances 0.000 claims abstract description 4
- 230000001105 regulatory effect Effects 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 45
- 238000003756 stirring Methods 0.000 claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 20
- 239000000284 extract Substances 0.000 claims description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 12
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 12
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 12
- 229940069521 aloe extract Drugs 0.000 claims description 12
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 12
- 150000004676 glycans Chemical class 0.000 claims description 12
- 229920002674 hyaluronan Polymers 0.000 claims description 12
- 229960003160 hyaluronic acid Drugs 0.000 claims description 12
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 12
- 229920001282 polysaccharide Polymers 0.000 claims description 12
- 239000005017 polysaccharide Substances 0.000 claims description 12
- 239000000230 xanthan gum Substances 0.000 claims description 12
- 229920001285 xanthan gum Polymers 0.000 claims description 12
- 235000010493 xanthan gum Nutrition 0.000 claims description 12
- 229940082509 xanthan gum Drugs 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229940098386 usnea barbata extract Drugs 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 claims description 9
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 claims description 9
- 241001474374 Blennius Species 0.000 claims description 7
- 239000001509 sodium citrate Substances 0.000 claims description 7
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 7
- 241000195474 Sargassum Species 0.000 claims description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 230000001276 controlling effect Effects 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 5
- 230000010355 oscillation Effects 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000002105 nanoparticle Substances 0.000 claims description 2
- 229960003966 nicotinamide Drugs 0.000 claims description 2
- 235000005152 nicotinamide Nutrition 0.000 claims description 2
- 239000011570 nicotinamide Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 230000003020 moisturizing effect Effects 0.000 abstract description 8
- 102000008186 Collagen Human genes 0.000 abstract description 4
- 108010035532 Collagen Proteins 0.000 abstract description 4
- 229920001436 collagen Polymers 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000035755 proliferation Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 230000003712 anti-aging effect Effects 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 5
- 230000002087 whitening effect Effects 0.000 description 5
- -1 pyrrolidone sodium carboxylate Chemical class 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000037488 Coccoloba pubescens Species 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000006302 Usnea Species 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000011246 composite particle Substances 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000004435 EPR spectroscopy Methods 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000007709 nanocrystallization Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000013319 spin trapping Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9733—Lichens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a colloidal platinum mask formula, which consists of the following components in percentage by weight: 4.5 to 9.8 weight percent of humectant, 3 to 5 weight percent of plant extract, 0.8 to 2.5 weight percent of thickener, 0.05 to 0.1 weight percent of EDTA disodium, 0.1 to 0.3 weight percent of nicotinamide, 0.3 to 1 weight percent of vitamin C, 0.3 to 1 weight percent of vitamin E, 10 weight percent of colloidal platinum-amino acid dispersion liquid and the balance of deionized water, and the pH is regulated to be 6.0 to 6.5 by using a pH regulator. Colloidal platinum-amino acid dispersions are prepared by the complex reaction of potassium chloroplatinate with cysteine and lysine in ethylene glycol. The colloidal platinum mask formula has the effects of moisturizing skin, improving cell activity, removing free radicals, promoting collagen proliferation, removing wrinkles and delaying aging, and is suitable for manufacturing masks made of non-woven fabrics, silk fibers, wood fibers, cotton fibers or copper ammonia fibers. In addition, the invention also discloses a preparation method of the colloidal platinum mask formula.
Description
Technical Field
The invention relates to a colloidal platinum mask formula and a preparation method and application thereof.
Background
With the continuous progress of economic development, people have become more and more important for physical health and maintenance. In skin care products for women and even men, the mask is a significant part and has a huge market size of billions of dollars. Among them, people have more general demands for functional masks for moisturizing, whitening, anti-wrinkling, anti-aging, etc. The efficacy of the mask is mainly contained in the formula liquid, and the mask is released from the mask and acts on the skin to achieve the effect. Collagen, amino acid, plant components and the like are purely natural moisturizing nutrient components, and are widely applied to mask formulas. For example, chinese patent CN107115219a discloses a fibroblast activation liquid surface film formulation, which contains multiple functional components such as amino acids, vitamins, reduced glutathione, biotin, etc., and can improve cell metabolism, promote collagen proliferation, increase dermis thickness, and realize skin care and anti-aging functions; chinese patent CN109316358A discloses a moisturizing cosmetic mask formula, which realizes a mild and comfortable lasting moisturizing effect through several amino acids, plant extracts and other components.
With the deep research, platinum element enters the field of vision of people and becomes an important functional component in the mask formula. Platinum is an inert element and has good safety to human skin. After nanocrystallization, the nano platinum and the colloidal platinum can quickly permeate the skin surface layer, have higher activity, show good oxidation resistance, can be combined with active oxygen to remove free radicals, prevent unsaturated fatty acid from being oxidized and blackened, keep collagen active and maintain the capability of absorbing and maintaining moisture, so that the effects of whitening skin, moisturizing skin and having elastic luster are realized. The development and application of the colloidal platinum are still to be further expanded, and the physical and chemical combination of natural components such as plant extracts, amino acids and the like and the colloidal platinum can improve the stability of the formula and the functional effect of the colloidal platinum, so the colloidal platinum is an important direction of the development of the current products.
Disclosure of Invention
Aiming at the defects of the existing method and the technology, according to the embodiment of the invention, the mask formula with outstanding moisturizing, whitening and anti-aging functions is expected to be obtained by a natural and mild blending, efficient and environment-friendly preparation method, and can be used for masks made of non-woven fabrics, silk fibers, wood fibers, cotton fibers and copper ammonia fibers, so that the functionality of the masks is greatly enhanced.
According to the embodiment, the colloidal platinum mask formula provided by the invention comprises the following components in parts by weight:
humectant: 4.5-9.8wt%
Plant extracts: 3-5wt%
And (3) a thickening agent: 0.8-2.5wt%
Disodium EDTA: 0.05-0.1wt%
Nicotinamide: 0.1-0.3wt%
Vitamin C:0.3-1wt%
Vitamin E:0.3-1wt%
Colloidal platinum-amino acid dispersion: 10wt%
The balance of deionized water, and the pH is regulated and controlled to be 6.0-6.5 by using a pH regulator. Wherein,
the humectant is a mixture of butanediol, oligomeric hyaluronic acid, sodium pyrrolidone carboxylate and algal polysaccharide, and based on the total amount of the colloidal platinum mask formula, the humectant comprises 3-5wt% of butanediol, 1-3wt% of oligomeric hyaluronic acid, 0.05-0.2wt% of sodium pyrrolidone carboxylate and 0.5-1.5wt% of algal polysaccharide;
the plant extract is a mixture of aloe extract, seaweed extract and Usnea barbata extract, and based on the total weight of the colloidal platinum mask formula, the aloe extract is 1-1.5wt%, the seaweed extract is 1-1.5wt%, and the Usnea barbata extract is 1wt%;
the thickener is a mixture of hydroxyethylcellulose and xanthan gum, and based on the total weight of the colloidal platinum mask formula, the thickener comprises 0.3-0.5wt% of hydroxyethylcellulose and 0.5-2wt% of xanthan gum;
the pH regulator is citric acid or sodium citrate;
in the colloidal platinum-amino acid dispersion, the particle size of the colloidal platinum-amino acid nanoparticles is 2-5nm.
According to one embodiment, the invention provides a colloidal platinum mask formulation wherein the colloidal platinum-amino acid dispersion is prepared by:
(1) 3-5 parts by mass of potassium chloroplatinate are dissolved in 50 parts by mass of ethylene glycol to obtain a solution A;1-3 parts by mass of cysteine are dissolved in 25 parts by mass of ethylene glycol, and 0.05-0.1 part by mass of triethanolamine is added to obtain a solution B;1-2 parts by mass of lysine is dissolved in 25 parts by mass of ethylene glycol to obtain a solution C; the three groups of solutions are all subjected to ultrasonic oscillation for 30 minutes;
(2) Adding the solution B into the solution A at a dropping speed of 1ml/min, controlling the temperature to be 65-80 ℃, and stirring for 2-3h;
(3) Adding the solution C into the mixed solution at the dropping speed of 2ml/min, and continuously stirring for 3-5h;
(4) Cooling the solution to room temperature, refrigerating and aging for 24 hours;
(5) Centrifuging the solution, washing the product with ethanol for 3 times, washing with water for 3 times, and vacuum drying;
(6) The prepared product was dispersed in water to prepare a dispersion containing 1000ppm of platinum.
According to the embodiment, the colloidal platinum mask formula provided by the invention is prepared by the following method:
(1) Accurately weighing the components;
(2) Adding butanediol, oligomeric hyaluronic acid, sodium pyrrolidone carboxylate, algal polysaccharide, nicotinamide, vitamin C and vitamin E into deionized water one by one, stirring and dissolving completely;
(3) Adding aloe extract, sargassum extract, usnea barbata extract and EDTA disodium, stirring and dissolving completely;
(4) Sequentially adding hydroxyethylcellulose, xanthan gum and colloidal platinum-amino acid dispersion liquid into the mixture, dissolving and dispersing uniformly, then adding citric acid and sodium citrate, adjusting pH to 6.0-6.5, and stirring for 1-2h.
According to the embodiment, the colloidal platinum mask formulation provided by the invention can be used for manufacturing masks made of non-woven fabrics, silk fibers, wood fibers, cotton fibers and copper ammonia fibers.
Compared with the prior art, the invention combines natural plant components and colloidal platinum-amino acid composite components, so that the functions of moisturizing, whitening and anti-aging are further enhanced. Wherein, the organic combination of colloidal platinum and amino acid not only has better stability of colloidal platinum particles, but also is beneficial to maintaining the activity of amino acid and enhancing the functionality. The following examples and test examples will demonstrate the following advantages of the present invention:
(1) The free radical inhibition rate is high, and the anti-aging effect is outstanding;
(2) The components are natural and mild, and the preparation is simple and environment-friendly.
Drawings
FIG. 1 is a transmission electron microscope image of the colloidal platinum-amino acid composite particles prepared in example 1.
Detailed Description
The invention is further illustrated by the following figures and specific examples. These examples should be construed as merely illustrative of the present invention and not limiting the scope of the present invention. Various changes and modifications to the present invention may be made by one skilled in the art after reading the description herein, and such equivalent changes and modifications are intended to fall within the scope of the present invention as defined in the appended claims.
The raw materials used in the following examples of the present invention are commercially available products unless otherwise indicated.
Example 1
First, a colloidal platinum-amino acid dispersion was prepared:
(1) 5g of potassium chloroplatinate was dissolved in 50g of ethylene glycol to obtain a solution A;2g of cysteine is dissolved in 25g of glycol, and 0.05g of triethanolamine is added to obtain a solution B;2g of lysine was dissolved in 25g of ethylene glycol to obtain a solution C. The three groups of solutions are all subjected to ultrasonic oscillation for 30 minutes;
(2) Adding the solution B into the solution A at a dropping speed of 1ml/min, controlling the temperature to 65 ℃, and stirring for 2 hours;
(3) Adding the solution C into the mixed solution at the dropping speed of 2ml/min, and continuously stirring for 3 hours;
(4) Cooling the solution to room temperature, refrigerating and aging for 24 hours;
(5) Centrifuging the solution, washing the product with ethanol for 3 times, washing with water for 3 times, and vacuum drying;
(6) The prepared product was dispersed in water to prepare a dispersion containing 1000ppm of platinum, and a transmission electron microscope image of colloidal platinum-amino acid composite particles in the dispersion was shown in FIG. 1.
The preparation of the mask formulation was then carried out:
(1) Weighing the following substances in mass: 4.5g of butanediol, 2g of oligomeric hyaluronic acid, 0.1g of pyrrolidone sodium carboxylate, 1g of algal polysaccharide, 1.5g of aloe extract, 1g of large leaf seaweed extract, 1g of Usnea barbata extract, 0.3g of hydroxyethyl cellulose, 2g of xanthan gum, 0.05g of disodium EDTA, 0.3g of nicotinamide, 0.8g of vitamin C, 0.8g of vitamin E, 10g of colloidal platinum-amino acid dispersion liquid and 74.6g of deionized water.
(2) Adding butanediol, oligomeric hyaluronic acid, sodium pyrrolidone carboxylate, algal polysaccharide, nicotinamide, vitamin C and vitamin E into deionized water one by one, stirring and dissolving completely;
(3) Adding aloe extract, sargassum extract, usnea barbata extract and EDTA disodium, stirring and dissolving completely;
(4) Sequentially adding hydroxyethylcellulose, xanthan gum and colloidal platinum-amino acid dispersion liquid into the mixture, dissolving and dispersing uniformly, then adding citric acid and sodium citrate, adjusting pH to 6.0, and stirring for 1-2h.
Example 2
First, a colloidal platinum-amino acid dispersion was prepared:
(1) 3g of potassium chloroplatinate was dissolved in 50g of ethylene glycol to obtain a solution A;1.5g of cysteine is dissolved in 25g of glycol, and 0.05g of triethanolamine is added to obtain a solution B;1.5g of lysine was dissolved in 25g of ethylene glycol to obtain a solution C. The three groups of solutions are all subjected to ultrasonic oscillation for 30 minutes;
(2) Adding the solution B into the solution A at a dropping speed of 1ml/min, controlling the temperature to 65 ℃, and stirring for 2 hours;
(3) Adding the solution C into the mixed solution at the dropping speed of 2ml/min, and continuously stirring for 3 hours;
(4) Cooling the solution to room temperature, refrigerating and aging for 24 hours;
(5) Centrifuging the solution, washing the product with ethanol for 3 times, washing with water for 3 times, and vacuum drying;
(6) The prepared product was dispersed in water to prepare a dispersion containing 1000ppm of platinum.
The preparation of the mask formulation was then carried out:
(1) Weighing the following substances in mass: 4g of butanediol, 2.5g of oligomeric hyaluronic acid, 0.1g of pyrrolidone sodium carboxylate, 1.2g of algal polysaccharide, 1.5g of aloe extract, 1.5g of large leaf seaweed extract, 1g of Usnea barbadensis extract, 0.3g of hydroxyethyl cellulose, 2g of xanthan gum, 0.05g of EDTA disodium, 0.3g of nicotinamide, 0.8g of vitamin C, 0.8g of vitamin E, 10g of colloidal platinum-amino acid dispersion liquid and 73.9g of deionized water.
(2) Adding butanediol, oligomeric hyaluronic acid, sodium pyrrolidone carboxylate, algal polysaccharide, nicotinamide, vitamin C and vitamin E into deionized water one by one, stirring and dissolving completely;
(3) Adding aloe extract, sargassum extract, usnea barbata extract and EDTA disodium, stirring and dissolving completely;
(4) Sequentially adding hydroxyethylcellulose, xanthan gum and colloidal platinum-amino acid dispersion liquid into the mixture, dissolving and dispersing uniformly, then adding citric acid and sodium citrate, adjusting pH to 6.0, and stirring for 1-2h.
Example 3
First, a colloidal platinum-amino acid dispersion was prepared:
(1) 5g of potassium chloroplatinate was dissolved in 50g of ethylene glycol to obtain a solution A;3g of cysteine is dissolved in 25g of glycol, and 0.1g of triethanolamine is added to obtain solution B;1.5g of lysine was dissolved in 25g of ethylene glycol to obtain a solution C. The three groups of solutions are all subjected to ultrasonic oscillation for 30 minutes;
(2) Adding the solution B into the solution A at a dropping speed of 1ml/min, controlling the temperature to 65 ℃, and stirring for 2 hours;
(3) Adding the solution C into the mixed solution at the dropping speed of 2ml/min, and continuously stirring for 3 hours;
(4) Cooling the solution to room temperature, refrigerating and aging for 24 hours;
(5) Centrifuging the solution, washing the product with ethanol for 3 times, washing with water for 3 times, and vacuum drying;
(6) The prepared product was dispersed in water to prepare a dispersion containing 1000ppm of platinum.
The preparation of the mask formulation was then carried out:
(1) Weighing the following substances in mass: 4.5g of butanediol, 3g of oligomeric hyaluronic acid, 0.1g of pyrrolidone sodium carboxylate, 0.5g of algal polysaccharide, 1.5g of aloe extract, 1.5g of large leaf seaweed extract, 1g of Usnea barbadensis extract, 0.4g of hydroxyethyl cellulose, 2g of xanthan gum, 0.05g of EDTA disodium, 0.3g of nicotinamide, 0.8g of vitamin C, 0.8g of vitamin E, 10g of colloidal platinum-amino acid dispersion liquid and 73.5g of deionized water.
(2) Adding butanediol, oligomeric hyaluronic acid, sodium pyrrolidone carboxylate, algal polysaccharide, nicotinamide, vitamin C and vitamin E into deionized water one by one, stirring and dissolving completely;
(3) Adding aloe extract, sargassum extract, usnea barbata extract and EDTA disodium, stirring and dissolving completely;
(4) Sequentially adding hydroxyethylcellulose, xanthan gum and colloidal platinum-amino acid dispersion liquid into the mixture, dissolving and dispersing uniformly, then adding citric acid and sodium citrate, adjusting pH to 6.0, and stirring for 1-2h.
Test examples
The test pieces of each example were subjected to a test for inhibiting the activity of superoxide anions. The spin-trapping technique was used for correlation detection by Electron Spin Resonance (ESR) test, and the results are shown in table 1. Wherein the inhibition rate is the scavenging rate of superoxide anion radical when tested for 6 minutes. Compared with a blank control group, the relative strength of the superoxide anion radical measured in each test group is obviously reduced, so that the corresponding inhibition rate of the superoxide anion radical is about 40%. This shows that the formulation of the embodiment 1-3 can endow the mask with outstanding free radical inhibition rate, thereby obtaining good whitening and anti-aging effects; on the other hand, the components of the formula are natural and mild, and the preparation is simple and environment-friendly, so that the formula has good market prospect.
TABLE 1 superoxide anion radical inhibition of the examples
| Relative intensity of superoxide anion radical (%) | Inhibition ratio (%) | |
| Example 1 | 60.27 | 39.73 |
| Example 2 | 62.92 | 37.08 |
| Example 3 | 59.44 | 40.56 |
| Blank control | 100 | - |
Claims (4)
1. The colloidal platinum mask formula is characterized by comprising the following components in percentage by weight:
humectant: 4.5-9.8wt%
Plant extracts: 3-5wt%
And (3) a thickening agent: 0.8-2.5wt%
Disodium EDTA: 0.05-0.1wt%
Nicotinamide: 0.1-0.3wt%
Vitamin C:0.3-1wt%
Vitamin E:0.3-1wt%
Colloidal platinum-amino acid dispersion: 10wt%
The balance of deionized water, regulating the pH to 6.0-6.5 by using a pH regulator, wherein,
the humectant is a mixture of butanediol, oligomeric hyaluronic acid, sodium pyrrolidone carboxylate and algal polysaccharide, and based on the total amount of the colloidal platinum mask formula, the humectant comprises 3-5wt% of butanediol, 1-3wt% of oligomeric hyaluronic acid, 0.05-0.2wt% of sodium pyrrolidone carboxylate and 0.5-1.5wt% of algal polysaccharide;
the plant extract is a mixture of aloe extract, seaweed extract and Usnea barbata extract, and based on the total weight of the colloidal platinum mask formula, the aloe extract is 1-1.5wt%, the seaweed extract is 1-1.5wt%, and the Usnea barbata extract is 1wt%;
the thickener is a mixture of hydroxyethylcellulose and xanthan gum, and based on the total weight of the colloidal platinum mask formula, the thickener comprises 0.3-0.5wt% of hydroxyethylcellulose and 0.5-2wt% of xanthan gum;
the pH regulator is citric acid or sodium citrate; in the colloidal platinum-amino acid dispersion, the particle size of the colloidal platinum-amino acid nanoparticles is 2-5nm.
2. The colloidal platinum mask formulation according to claim 1, wherein the colloidal platinum-amino acid dispersion is prepared by the following method:
(1) 3-5 parts by mass of potassium chloroplatinate are dissolved in 50 parts by mass of ethylene glycol to obtain a solution A;1-3 parts by mass of cysteine are dissolved in 25 parts by mass of ethylene glycol, and 0.05-0.1 part by mass of triethanolamine is added to obtain a solution B;1-2 parts by mass of lysine is dissolved in 25 parts by mass of ethylene glycol to obtain a solution C; the three groups of solutions are all subjected to ultrasonic oscillation for 30 minutes;
(2) Adding the solution B into the solution A at a dropping speed of 1ml/min, controlling the temperature to be 65-80 ℃, and stirring for 2-3h;
(3) Adding the solution C into the mixed solution at the dropping speed of 2ml/min, and continuously stirring for 3-5h;
(4) Cooling the solution to room temperature, refrigerating and aging for 24 hours;
(5) Centrifuging the solution, washing the product with ethanol for 3 times, washing with water for 3 times, and vacuum drying;
(6) The prepared product was dispersed in water to prepare a dispersion containing 1000ppm of platinum.
3. The preparation method of the colloidal platinum mask formula is characterized by comprising the following steps:
(1) Accurately weighing the components;
(2) Adding butanediol, oligomeric hyaluronic acid, sodium pyrrolidone carboxylate, algal polysaccharide, nicotinamide, vitamin C and vitamin E into deionized water one by one, stirring and dissolving completely;
(3) Adding aloe extract, sargassum extract, usnea barbata extract and EDTA disodium, stirring and dissolving completely;
(4) Sequentially adding hydroxyethylcellulose, xanthan gum and colloidal platinum-amino acid dispersion liquid into the mixture, dissolving and dispersing uniformly, then adding citric acid and sodium citrate, adjusting pH to 6.0-6.5, and stirring for 1-2h.
4. The colloidal platinum mask formulation according to claim 1 or 2 for mask preparation of non-woven fabrics, silk fibers, wood fibers, cotton fibers or copper ammonia fibers.
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