CN102440943B - Composition for caring and improving aged or damaged skin - Google Patents
Composition for caring and improving aged or damaged skin Download PDFInfo
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- CN102440943B CN102440943B CN 201110244777 CN201110244777A CN102440943B CN 102440943 B CN102440943 B CN 102440943B CN 201110244777 CN201110244777 CN 201110244777 CN 201110244777 A CN201110244777 A CN 201110244777A CN 102440943 B CN102440943 B CN 102440943B
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Abstract
The invention discloses a cosmetic composition for caring and improving aged or nutrient-deficient skin or skin subjected to environmental damage. The composition comprises nanogold, high-energy source and/or peptides for skin cell metabolism, and one or more antioxidants. The components have favorable coordinating actions, and can improve the skin in the aspects of visual appearance, physiological functions, clinical characteristics and biophysical features.
Description
Technical field
The present invention relates to cosmetic composition, described cosmetic composition comprises nanometer gold, is used for the high-energy source of skin cell metabolism and/or wins peptide class, one or more antioxidants.Can be used for nursing and improve aging, malnutrition or be subjected to the skin of environmental nuisance, can provide improvement in visual appearance, physiologic function, clinical characteristics and biophysics's characteristic aspect of skin.
Technical background
Gold is used for skin protection and comes from ancient Egypt the earliest, and spun gold is implanted the skin corium defying age, and in ancient Roman, the doctor treats dermatosis with gold; In the pharmacopeia on Chinese history, native gold has various medical value, and the holy Li Shizhen (1518-1593 A.D.) Compendium of Material Medica of Ming Dynasty's medicine has done to study in great detail most record to its property of medicine, consumption.Flourish youth's work " revise and enlarge with Chinese medicine and examine " of the pharmacists Junichiro Koizumi of Japan is also on the books.The food additive scope is formally classified native gold as in the 16 meeting of nineteen eighty-three The World Health Organization's food additive regulations committee (CCFA) (Hague, Detch meeting), classifies A table the as No. 310.
Nanometer gold has very strong adsorption function to protein, DNA etc., and can not change the character of adsorbed material, and the antibiotic property of nano gold sol, safety, toxicity have been passed through FDA (Food and Drug Adminstration) (FDA) authentication.Nanometer gold is studied widely and is used as the good pharmaceutical carrier of character, and nanometer gold can play the effect of carrying the active component Transdermal absorption, thereby improves skin to the absorption of effective ingredient.
Discover that nanometer gold has the promotion cell proliferation, the function that enhances metabolism more.The inventor also finds that nanometer gold all can promote cell proliferation to the human skin cell in the finite concentration scope, has dose dependent and time dependence, and on cell proliferation shows as the significance facilitation and along with the increase of time, promotes multiplication capacity to strengthen.
Along with age ageing, the visual appearance, physical characteristic and the physiological function that contact adverse environmental factors or malnutrition skin for a long time change, and are considered on the cosmetology not expected.Often show as clinically that pachylosis, drying, sensitivity and fragility increase, cutis laxa, elasticity reduce, wrinkle increases, atrophoderma, corium transparency increase and make skin shinny, but generally can keep its whole geometry graphical appearance, often is canescence.These are the hypometabolism with the aging of age all, contacts adverse environmental factors for a long time or malnutrition has close relationship.
Preventing skin aging and the wrinkle that goes down in advance is the eternal problem of cosmetics research and development.
Because the outermost horny layer of skin itself has as defence from external allotrylic barrier physiological function, so just simply relevant functional components is fitted in the external agent, be can not obtain abundant Transdermal absorption, can not show the original effect of this composition.Used Percutaneous absorption enhancers such as dimethyl sulfoxine, dimethyl formamide, dimethyl acetamide, methyl decyl sulfoxide in recent years, purpose is to improve the percutaneous absorbability of various materials.Yet these Percutaneous absorption enhancers do not provide satisfied Transdermal absorption facilitation effect, and because skin irritation erythema etc. occurred at skin by force and sometimes, so, be not desirable especially aspect its effect, safety, the use.
In order to improve the functional of functional type cosmetics, it is good and do not have a functional cosmetics compositions of negative interaction to need to continue development effectiveness.
Nanometer gold also has been used in the cosmetics, for example: Chinese patent: application number 200810045539.3 disclosed " a kind of preparation method of eye-care cosmetic " has proposed a kind of prescription and preparation method that contains the eye-care cosmetic of nanometer gold.
The inventor finds, because nanometer gold self can promote the metabolism of skin, and can promote the Transdermal absorption of other functional components, nanometer gold, the compositions that is used for the high-energy source of skin metabolism and/or wins peptide class, one or more antioxidants are in nursing and improve aging, malnutrition or be subjected to and show synergism characteristic aspect the skin of environmental nuisance.
Summary of the invention
The present invention is by providing a kind of cosmetic composition that contains nanometer gold, for nursing with improve aging, malnutrition or be subjected to the skin of environmental nuisance that a kind of unique combination thing is provided.
Described compositions contains: nanometer gold, the high-energy source that is used for skin cell metabolism and/or victory peptide class, one or more antioxidants.Wherein with the form configuration of compositions by the beauty treatment mixture.
Nanometer gold is with the high-energy source that is used for skin cell metabolism and/or win peptide class and one or more antioxidant combination, when nanometer gold self promotes cell metabolism, nanometer gold has also promoted the Transdermal absorption of other material in the compositions, and nanometer gold and be used for the high-energy source of skin cell metabolism and/or win between peptide class and antioxidant producing synergism, thereby produced beyond thought beneficial effect.
According to the present invention, described cosmetic composition comprises nanometer gold, and the particle size range of nanometer gold is 5nm to 100nm, preferred 5nm to 50nm, more preferably 10nm to 30nm.Preferably, adopting with the polyvinylpyrrolidone is protective agent, is the nano gold sol of the method preparation of Reducing agent reduction gold chloride with the sodium citrate, and the nanometer gold concentration of nano gold sol is 100 μ mol/L to 10mmol/L, preferred 200 μ mol/L to 1mmol/L.
In embodiment of the present invention, compositions comprises the weight 0.0001%-10% by described compositions, preferred 0.0005% to 0.1% nanometer gold.
Compositions of the present invention can be included in the cosmetic carrier.Cosmetic carrier can comprise emulsion, cream frost, washing liquid, solution, gel or ointment, or any other carrier well known by persons skilled in the art.In aspect concrete, emulsion can be emulsion oil-in-water or water-in-oil emulsion.Solution of the present invention can be, for example: aqueous solution or water-alcohol solution.Anhydrous base material can be lip pomade or powder.
Aspect other indefiniteness, compositions of the present invention can be included in aging products or the humidification product, and perhaps being designed to provides in any product of benefit to skin.In the concrete aspect, compositions can be fit to during use use one day at least one times, twice, three times, four times, five times or more times.Compositions can also be chemical compatibility.
According to the present invention, described compositions contains such as the lactobacillus ferment, the wheat protein of hydrolysis, glycine, this class of arginine and methionine is used for the high-energy source of skin cell metabolism, the victory peptide class that described compositions contains is selected from: two victory peptides, palmitoyl tripeptide 3, four victory peptides, Wushengtai, six victory peptides, seven victory peptides, eight victory peptides, nine victory peptides or their mixture, one or more antioxidants that described compositions contains are selected from: nicotiamide, vitamin A and derivant thereof, vitamin E and derivant thereof, ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbate, the ascorbic acid polypeptide, the ascorbyl dipalmitate, methyl silicane alcohol ascorbic acid, the ascorbyl stearate, ascorbic acid tocopherol potassium phosphate, cysteine, tocopherol and derivant thereof, ferulic acid, epicatechol gallate, gallateoctylester, propyl gallate, PGS, tocopherol acetas, Vitamin E linoleate, tocopheryl nicotinate, the fertility succinate, rosmarinic acid, superoxide dismutase, catalase, glutathione peroxidase, metallothionein, Fructus Chaenomelis sulfydryl enzyme, coenzyme Q10 or their mixture.
This cosmetic composition can comprise the weight 0.01% to 30% by described compositions, preferred 0.1% to 9% the high-energy source that is used for skin cell metabolism and/or victory peptide class; Compositions comprises the weight 0.05% to 20% by described compositions, one or more antioxidants of preferred 0.1 to 9%.
In claim and/or description, word " one, one " " to contain " when being used in conjunction with term, it can refer to " one ", but also meets " one or more ", " at least one " and " one 's or greater than one " implication.
The present composition is used for improving skin vision outward appearance, physiologic function or the biophysics's characteristic that is subjected to all multifactor impacts and changes.Wherein said all multifactor for example age ageings, long-term Exposure to Sunlight, adverse environment condition, such as pollutant, family apply some make up, disease pathological changes, smoking or underfed factor.Wherein the variation of said visual appearance comprises, for example, the appearance of microgroove and wrinkle, depression increase, loss of elasticity, fecundity forfeiture and the forfeiture of color and luster uniformity, coarse texture, mottled pigmentation, its these and other aspect of the present invention is done below further and is described in detail.
The A nanometer gold
Discover that nanometer gold has the promotion cell proliferation more, the function that enhances metabolism, the inventor also finds that nanometer gold also all can promote cell proliferation to the human skin cell in the finite concentration scope, have dose dependent and time dependence, on cell proliferation shows as the significance facilitation and along with the increase of time, promote multiplication capacity to strengthen, nanometer gold is to not influence of cancerous cell simultaneously, and the age of copying life time and donor of fibroblast in-vitro multiplication ability detection all ages and classes human skin fibroblast is negative correlation, and one-year-old its cells in vitro of every increase of donor age copies life time and reduced for 0.2 generation.
Nanometer gold self can promote the metabolism of skin, can promote the Transdermal absorption of other functional components, the high-energy of nanometer gold, skin metabolism source and/or the compositions that wins peptide class, one or more antioxidants are in nursing and improve aging, malnutrition or be subjected to and show synergism characteristic aspect the skin of environmental nuisance.
B is used for the high-energy source of skin cell metabolism
In typical embodiment, described high-energy source comprises the lactobacillus ferment.In specific embodiment, origin hang oneself phosphagen-derived molecules of microorganism of biotechnology modified in described high-energy source is formed.It is made up of wheat protein, glycine, arginine and the methionine of glycerol, lactobacillus ferment, hydrolysis.As embodiment, this energy source can trade name PHOSPHOVITAL
TMBe commercially available, on sale in French Si Dama company.This material provides the high-energy that is used for skin cell metabolism source.The working concentration of this material in prescription is more than 0.05% to 30% or 30%.
The C antioxidant
Antioxidant is during a class can help to catch also and free radical, thereby dispels a class material of radical pair human body infringement.Radical reaction is to cause an old and feeble key factor, and scientist is by experimental results demonstrate that free-radical oxidation is the major reason that causes aging, cell injury and degeneration.Free radical is that a class is present in the harmful substance that can damage cell in the body cell.In a kind of biological chain type course of reaction in body, the existence of free radical impels the interior old and feeble materials such as melanin, lipofuscin and ceroid that produce of skin histology.Biological itself have defence capability to free radical, but this ability increases along with the age and progressively goes down, the active attenuating.
The D cosmetic carrier
Compositions of the present invention all is effective in all types of cosmetic carrier.The indefiniteness embodiment of suitable cosmetic carrier comprises emulsion, cream, washing liquid, solution (moisture and water-alcohol), anhydrous base material (as, lip pomade and powder), gel and ointment, perhaps by other method or aforesaid any combination, can know as those skilled in the art, change with other suitable carriers apparent to those skilled in the art being suitable for and use in the present invention.
In preferred embodiments, cosmetic carrier is selected from emulsion oil-in-water, the encapsulate pearl in water-alcohol solution or the anhydrous system.With regard to emulsion oil-in-water, this emulsion and composition and production method be well known in the art.Yet, importantly select concentration and the combination of chemical compound and extract, combination is that chemical is compatible, and does not form complex and precipitate from finished product.
The E beautification product
Compositions of the present invention can also be used for a lot of beautification products, includes but not limited to humidification cream, beneficial skin cream and washing liquid, gel, ointment, foundation cream, late frost, lip pomade, cleaning agent, toner, facial film and/or colored beautification product.The first-selected aging products that is used for of compositions is used for facial and other body parts, the most particularly stays the product on the skin.
F can combine other chemical compound and the reagent of use with the present invention
Compositions of the present invention can contain other beneficial agents and chemical compound, and for example, acute or chronic humidizer (comprises, for example, wetting agent, occludent and the reagent that influences the natural humidification mechanism of skin), plant extract, antioxidant, skin whitener is (for example, hydroquinone), emollient, counter-stimulus, vitamin, trace metal, antimicrobial, aromatic and/or dyestuff and coloring components.
1, humidizer
The indefiniteness embodiment of the humidizer that can use in the present composition comprises aminoacid, chondroitin sulfate, diglycerol, erythritol, fructose, glucose, glycerol, polyglycerine, dihydroxylic alcohols, 1,2,6-hexanetriol, Mel, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactose, maltose alcohol, maltose, mannitol, the natural humidification factor, the PEG-15 butanediol, the polyglycereol sorbitol ester, 2-pyrrolidone-5-carboxylic acid's salt, potassium PCA, propylene glycol, D-Glucuronic acid sodium salt, sodium PCA, sorbitol, sucrose, trehalose, urea and xylitol.
Other embodiment comprises acetylated lanolin; Acetylated lanolin alcohols.; acrylate/acrylic acid C10-C30 alkyl ester cross-linked polymer; acrylate copolymer; alanine; Sargassum extract; Aloe Barbadensis Miller; the Aloe Barbadensis Miller extract; barbados aloe gel; the Althaea officinalis extract; the Dry Flo PC; aluminium stearate; almond oil; arginine; the arginine aspartic acid; the arnica montana extract; ascorbic acid; anti-bad blood is calculated basic cetylate; aspartic acid; American Avocado Tree oil; barium sulfate; gas barrier sheath esters; butanols; Cera Flava; tadenan; cupreol; the Cortex Betulae Luminiferae extract; the borage extract; 2-bromo-2-nitro the third-1; the 3-glycol; the butchers broom extract; butanediol; Flos Inulae extract; Flos Inulae oil; candelilla wax; Oleum Brassicae campestris; caprylic/capric triglyceride; Cardamom oil; Brazil wax; carrageenin; carrot oil; Oleum Ricini; ceramide; ceresine; spermaceti/Brij-721-5; spermaceti/Brij-721-12; spermaceti/Brij-721-20; sad spermaceti/stearyl; cetyl polyoxyethylene ether-20; cetyl polyoxyethylene ether-24; the spermol vinyl acetate; the spermol caprylate; the spermol cetylate; chamomile oil; cholesterol ester; Cholesteryl hydroxystearate; citric acid; Salvia scalarea oil; cocoa butter; cocoanut oil alcohol caprylic/capric ester; Oleum Cocois; collagen; collagen amino acid; Semen Maydis oil; fatty acid; decyl oleate; dextrin; diazolidinylurea; gather and the methylsiloxane copolyol; dimethiconol; dioctyl adipate; dioctyl succinate; dipentaerythritol six caprylates/six decanoins; DMDM Hydantoin; erythritol; ethoxy Kiel glycol; inferior ethyl oleate; blue gum oil; Radix Oenotherae erythrosepalae oil; fatty acid; gelatin; Geranium macrorrhizum Zdravets oil; Fructus Vitis viniferae amine; the glucose glutamate; glutamic acid; glycerin polyoxyethylene ether-26; glycerol monohydroxystearate; glycerol monolaurate; glycerol; glycerol distearate; glycerol monohydroxystearate; the glycerol linoleate; glycerine myristate ester; glycerol has acid esters; glyceryl stearate; glyceryl stearate SE; glycine; ethylene glycol stearate; ethylene glycol stearate SE; glycosaminoglycan; Oleum Vitis viniferae; hazelnut kernel oil; ethylene glycol; Mel; hyaluronic acid; hybrid safflower oil; hydrogenated palm glyceride; hydrogenated palm kernel oil; oil with hydrogenated soybean; h-tallow glyceride; hydrogenated vegetable oil; hydrolytic collagen; elastin hydrolysis; the hydrolysis glycosaminoglycan; hydrolysis of keratin; hydrolyzed soybean protein; hydroxylated lanolin; strong proline; imidazoline urea; amido formic acid iodine propine butyl ester; Standamul 7061; the hard straight sour different cetyl of stearyl; Ceraphyl 140A; the isostearic acid isopropyl ester; isopropyl lanolate; isopropyl myristate; isopropyl palmitate; isopropyl stearate; isostearoyl amine DEA; isostearic acid; the iso stearyl lactate; the iso stearyl pivalate; Jasmin oil; the Jojoba wood oil; zostera marina; candlenut tree core oil; lanolin alcohol polyoxyethylene ether-16; lanolin alcohol polyoxyethylene ether-10 acetas; lanoline; lanoceric acid; lanolin alcohol; lanolin oil; lanolin wax; Oleum lavandula angustifolia; lecithin; Fructus Citri Limoniae oil; linoleic acid; linolenic acid; core oil; magnesium stearate; magnesium sulfate; maltose alcohol; Matricariae aetheroleum; Glucate SS; methyl silicane alcohol PCE; microwax; mineral oil; ermine oil; Mortierella oil; Tetradecyl lactate; myristyl myristate; the propanoic acid myristin; neopentyl glycol dicaprylate/dicaprate; octyldodecanol; myristic acid octyl group dodecyl ester; octyl group dodecyl stearyl stearate; octyl hydroxystearate; octyl palmitate; ethylhexyl salicylate; octyl stearate; oleic acid; olive oil; Palmic acid; pantethine; pantothenylol; paraffin; peach kernel oil; Oleum Arachidis hypogaeae semen; PEG-8 C12-18 ester; the PEG-15 coco amine; the PEG-150 distearate; the PEG-60 castor oil hydrogenated; the PEG-20 Glucate SS; the high oleate of PEG40 anhydro sorbitol; PEG-5 Semen sojae atricolor alcohol sterol; PEG-10 Semen sojae atricolor alcohol; the PEG-2 stearate; the PEG-8 stearate; the PEG-20 stearate; the PEG-32 stearate; the PEG-40 stearate; the PEG-50 stearate; the PEG-100 stearate; the PEG-150 stearate; pentadecanolide; Oleum menthae; vaseline; phospholipid; poly-amino sugar condensation substance; polyglycereol-3-diisopstearate; polyquaternary ammonium salt-24; anhydro sorbitol polyoxyethylene ether 20; anhydro sorbitol polyoxyethylene ether 40; anhydro sorbitol polyoxyethylene ether 60; anhydro sorbitol polyoxyethylene ether 80; anhydro sorbitol polyoxyethylene ether 85; potassium myristate; potassium palmitate; potassium sorbate; potassium stearate; propylene glycol; propylene glycol dicaprylate/dicaprate; propylene glycol dioctyl acid esters; propylene glycol dipelargonate; the propylene glycol laurate; propylene glycol stearate; propylene glycol stearate SE; polyvinylpyrrolidone, the plain dipalmitate of pyrroles; quaternary ammonium salt-15; the product of dihydro tallow alkyl dimethyl ammonium chloride and hectorite; quaternary ammonium salt-22; retinol; retinyl palmitate; 2 rices oil; RNA; oil of rosemary; Oleum Rosae Rugosae; safflower oil; the Mus tail oil; salicylic acid; Oleum Santali albi; serine; serum albumin; Oleum sesami; Adeps Bovis seu Bubali resin; the silk powder; sodium chondroitin sulfate; hyaluronate sodium; sodium lactate; sodium palmitate; polyglutamic acid sodium; sodium stearate; soluble collagen; sorbic acid; sorbitan laurate; sorbitan oleate; sorbitan palmitate; Arlacel-83; sorbitan monostearate; sorbitol; soybean oil; sphingolipid; squalane; Squalene; stearmide MEA-stearate; stearic acid; stearyl glycyrrhetinate; the stearyl heptanoate; stearyl stearate; sunflower seed oil; Semen pruni armeniacae oil; synthetic bees wax; tocopherol; tocopherol acetas; Vitamin E linoleate; neopentanoic acid tridecyl ester; stearic acid tridecyl ester; triethanolamine; glyceryl tristearate; Semen Tritici aestivi germ oil; and cananga oil; or their mixture.
2, plant extract
The indefiniteness embodiment of the plant extraction/extracting solution that can use in cosmetic composition of the present invention comprises the extraction/extracting solution of preferred Folium Aloe, Radix Glycyrrhizae extraction/extracting solution, Semen Litchi extraction/extracting solution, Semen Coicis extraction/extracting solution, Semen Vitis viniferae extraction/extracting solution, red Punica granatum L. extraction/extracting solution, Semen Ginkgo extraction/extracting solution, Fructus Chaenomelis ferment extraction/extracting solution, Spica Prunellae extraction/extracting solution, Flos Chrysanthemi Indici extraction/extracting solution, Ganoderma extraction/extracting solution, Herba Portulacae extraction/extracting solution, Folium Ginkgo extraction/extracting solution, Radix Scutellariae extraction/extracting solution, Radix Gentianae extraction/extracting solution, Australia Fructus Fragariae Ananssae extraction/extracting solution, honey peach extraction/extracting solution, lemonweed leaves of plants extraction/extracting solution, Fructus Mali pumilae extraction/extracting solution, Rhizoma Dioscoreae extraction/extracting solution, Rosehips extraction/extracting solution, Radix Angelicae Sinensis extraction/extracting solution, Herba Centellae extraction/extracting solution, green tea extraction/extracting solution, Flos Matricariae chamomillae extraction/extracting solution, Herba Taraxaci extraction/extracting solution, Fructus Ananadis comosi extraction/extracting solution, Bulbus Cardiocrini Cathayani extraction/extracting solution, Folium Artemisiae Argyi extraction/extracting solution, Radix et Caulis Opuntiae Dillenii extraction/extracting solution, Radix Hamamelidis Mollis extraction/extracting solution, Cortex Mori extraction/extracting solution, Gherkin extraction/extracting solution, seaweed extract/extracting solution, Radix Paeoniae Alba extraction/extracting solution, Herba Saussureae Involueratae extraction/extracting solution, Herba Leonuri extraction/extracting solution, Radix Puerariae extraction/extracting solution, Semen Castaneae extraction/extracting solution, green tea extraction/extracting solution, bodhi leaves and/or bark extraction/extracting solution, marigold flower extraction/extracting solution, bashfully blade of grass and/or skin extraction/extracting solution, Folium olive and/or fruit extraction/extracting solution, Radix Ginseng extract extraction/extracting solution, Herba Plantaginis extract extraction/extracting solution, propolis extraction/extracting solution, leaf of Herba Rosmarini Officinalis extraction/extracting solution, sage extraction/extracting solution, fly water Ji extraction/extracting solution, til seed extraction/extracting solution, mandarin orange skin extraction/extracting solution, Testa Tritici and/or Fructus Tritici aestivi extraction/extracting solution, Herba bromi japonici plumule extraction/extracting solution, or their mixture, more preferably extraction/the extracting solution of Rosehips, green tea extraction/extracting solution, Semen Vitis viniferae extraction/extracting solution, or their mixture.According to the present invention, cosmetic composition can comprise the weight 0.0001% to 2% by described compositions, and is preferred 0.001% to 0.5%, and more preferably additional plant extraction/extracting solution of 0.002% to 0.15%.
3, can combine other chemical compound and the reagent of use with the present invention
Other chemical compound that can use in the present composition and the indefiniteness embodiment of reagent comprise that skin whitener (for example: kojic acid, hydroquinone, ascorbic acid and derivant, retinoid and derivant thereof), vitamin (for example: vitamin D, E, A, K, C), trace metal is (for example: zinc, calcium and selenium), counter-stimulus (for example: allantoin, peanut extract, antiinflammatory), dyestuff and coloring components (for example, D﹠amp; No. four indigo plants of C, D﹠amp; No. five, C is green, D﹠amp; The C orange, D﹠amp; C17 number red, D﹠amp; C33 number red, D﹠amp; No. two purples of C, D﹠amp; The C10 Huang, D﹠amp; C11 Huang and DEA-cetyl phosphate ester), and antiseptic (for example: Butylated hydroxyanisole), emollient (that is: organic ester, fatty acid, lanoline and derivant thereof, plant and animal oil ﹠ fat, and diglyceride and triglyceride), and natural and artificial aromatic.
In addition, can produce prevention to microbiological effect by antiseptic, as various antibacteriums and antifungal, include but not limited to p-Hydroxybenzoate (for example, p-Hydroxybenzoate, methaform, phenol, sorbic acid or their compositions).
Preferred embodiment
The not homophase (A, B, C, D, E) that compositions according to the present invention comprises compositions below has been described in detail in detail, has mixed the embodiment that each obtains final products mutually through heating and/or being cooled to proper temperature.
The embodiment 1 nourishing late frost of whitening
Step: under the state that appropriateness stirs, heat A respectively mutually and B to 65 ℃, after stirring B is added to A mutually in and the continuation stirring until gained mixture mix homogeneously.Then described mixture is cooled to 50 ℃ and C is added to, continues to be cooled to 40 ℃ and add the D phase, add the E phase subsequently, be stirred to mix homogeneously, be cooled to 35 ℃.
Embodiment 2 crease-resistant easypro eye creams alive
Step: under the state that appropriateness stirs, heat A respectively mutually and B to 65 ℃, after stirring B is added to A mutually in and the continuation stirring until gained mixture mix homogeneously.Then described mixture is cooled to 50 ℃ and C is added to, continues to be cooled to 40 ℃ and add the D phase, add the E phase subsequently, be stirred to mix homogeneously, be cooled to 35 ℃.
Embodiment 3 crease-resistant moisturizers
Step: under the state that appropriateness stirs, heat respectively A mutually with B to 65 ℃, after stirring B is added to A mutually in and continue to stir until gained mixture mix homogeneously, then the gained mixture is cooled to 50 ℃ and C is added to, continue to be cooled to 40 ℃ and add the D phase, add the E phase subsequently, be stirred to mix homogeneously, be cooled to 35 ℃.
Example 4 cosmetic water
Step: under the state that appropriateness stirs, heat A respectively mutually and B to 65 ℃, after stirring B is added to A mutually in and continuation stirring gained mixture until mix homogeneously.Then described mixture is cooled to 40 ℃ and C is added to, is stirred to mix homogeneously, be cooled to 35 ℃.
Example 5 elite
Step: under the state that appropriateness stirs, heat A respectively mutually and B to 65 ℃, after stirring B is added to A mutually in and continuation stirring gained mixture until mix homogeneously.Then described mixture is cooled to 50 ℃ and C is added to.The gained mixture continues to be cooled to 40 ℃ and add the D phase, adds the E phase subsequently, is stirred to mix homogeneously, is cooled to 35 ℃.
Although illustrative embodiment of the present invention has been enclosed in above description, should be understood that certainly those skilled in the art obviously can carry out various improvement.
Claims (2)
1. crease-resistant moisturizer, it is characterized in that: the component prescription is:
The A phase: glycerol 5%, nanometer gold concentration are that nano gold sol 13%, sodium hydrogen phosphate 0.5%, ferulic acid 0.5%, the water of 400 μ mol/L is an amount of;
B phase: Oleum Vitis viniferae 4%, carboxymethyl chitosan 0.2%, hydrogenated lanolin 2%, stearic acid 2%, glyceryl monostearate 3%;
C phase: palmitoyl oligopeptide 0.5%, trehalose 1%, PHOSPHOVITAL
TM3%, hyaluronic acid 0.5%, ascorbic acid polypeptide 1%;
D phase: triethanolamine 1.16%, water 1.60%;
E phase: methyl hydroxybenzoate 0.1%, ethyl hydroxybenzoate 0.1%;
The preparation method of described crease-resistant moisturizer is: under the state that appropriateness stirs, heat respectively A mutually with B to 65 ℃, after stirring, with B be added to A mutually in and continue to stir until gained mixture mix homogeneously, then the gained mixture is cooled to 50 ℃ and C is added to, continue to be cooled to 40 ℃ and add the D phase, add the E phase subsequently, be stirred to mix homogeneously, be cooled to 35 ℃, namely.
2. method for preparing the described crease-resistant moisturizer of claim 1, it is characterized in that: under the state that appropriateness stirs, heat A respectively mutually and B to 65 ℃, after stirring, with B be added to A mutually in and the continuation stirring until gained mixture mix homogeneously, then the gained mixture is cooled to 50 ℃ and C is added to, continue to be cooled to 40 ℃ and add the D phase, add the E phase subsequently, be stirred to mix homogeneously, be cooled to 35 ℃, namely.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310455248.2A CN103479551B (en) | 2011-08-25 | 2011-08-25 | Cosmetic water and preparation method |
| CN201310455371.4A CN103479552B (en) | 2011-08-25 | 2011-08-25 | Crease-resistant easypro eye cream alive and preparation method |
| CN 201110244777 CN102440943B (en) | 2011-08-25 | 2011-08-25 | Composition for caring and improving aged or damaged skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110244777 CN102440943B (en) | 2011-08-25 | 2011-08-25 | Composition for caring and improving aged or damaged skin |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310455371.4A Division CN103479552B (en) | 2011-08-25 | 2011-08-25 | Crease-resistant easypro eye cream alive and preparation method |
| CN201310455902.XA Division CN103479554B (en) | 2011-08-25 | 2011-08-25 | Whitening and nourishing night cream and preparation method |
| CN201310455248.2A Division CN103479551B (en) | 2011-08-25 | 2011-08-25 | Cosmetic water and preparation method |
| CN201310455399.8A Division CN103479553B (en) | 2011-08-25 | 2011-08-25 | Essence and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102440943A CN102440943A (en) | 2012-05-09 |
| CN102440943B true CN102440943B (en) | 2013-09-11 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110244777 Active CN102440943B (en) | 2011-08-25 | 2011-08-25 | Composition for caring and improving aged or damaged skin |
| CN201310455248.2A Active CN103479551B (en) | 2011-08-25 | 2011-08-25 | Cosmetic water and preparation method |
| CN201310455371.4A Active CN103479552B (en) | 2011-08-25 | 2011-08-25 | Crease-resistant easypro eye cream alive and preparation method |
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| CN201310455248.2A Active CN103479551B (en) | 2011-08-25 | 2011-08-25 | Cosmetic water and preparation method |
| CN201310455371.4A Active CN103479552B (en) | 2011-08-25 | 2011-08-25 | Crease-resistant easypro eye cream alive and preparation method |
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| Publication number | Publication date |
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| CN103479551A (en) | 2014-01-01 |
| CN103479552A (en) | 2014-01-01 |
| CN102440943A (en) | 2012-05-09 |
| CN103479551B (en) | 2015-10-21 |
| CN103479552B (en) | 2015-10-21 |
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