CN103479551A - Toner and preparation method - Google Patents
Toner and preparation method Download PDFInfo
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- CN103479551A CN103479551A CN201310455248.2A CN201310455248A CN103479551A CN 103479551 A CN103479551 A CN 103479551A CN 201310455248 A CN201310455248 A CN 201310455248A CN 103479551 A CN103479551 A CN 103479551A
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Abstract
The invention aims at providing a toner and a preparation method. A formula of components of the toner comprises a phase A, a phase B and a phase C, wherein the phase A comprises 13% of nanogold sol with nanogold concentration of 400 micromoles/L, 5% of butanediol, 0.5% of disodium hydrogen phosphate and an appropriate amount of water; the phase B comprises 0.5% of natural methyl glycine proline, 4% of PHOSPHOVITALTM, 0.5% of ferulic acid, 1% of tocopherol succinate, 0.8% of rosmarinic acid, 0.5% of calendula extracts, 0.5% of mycose and 2% (10%) of mucopolysaccharide; and the phase C comprises 0.1% of sodium PCA, 0.05% of rose floral water, 0.1% of sea algae extracts and 0.1% of phenoxyethanol. According to the toner and the preparation method, a unique composition for nursing and improving skins which are aged, lack of nutrition and harmed by environments is provided.
Description
The application is dividing an application of " for nursing and improve the compositions of aging or damaged skin ", the applying date of original application is on 08 25th, 2011, application number is 201110244777.9, the invention and created name of original application is " for nursing and improve the compositions of aging or damaged skin ", and invention and created name during mandate is " crease-resistant moisturizer and preparation method ".
Technical field
The present invention relates to cosmetic composition, described cosmetic composition comprises nanometer gold, for the high-energy of skin cell metabolism, originates and/or win peptide class, one or more antioxidants.Can be used for nursing and improve aging, malnutrition or be subject to the skin of environmental nuisance, can provide improvement in visual appearance, physiologic function, clinical characteristics and biophysics's characteristic aspect of skin.
Technical background
Gold comes from ancient Egypt the earliest for skin protection, and spun gold is implanted the skin corium defying age, and, in ancient Roman, the doctor treats dermatosis with gold; In pharmacopeia on Chinese history, native gold has various medical value, and the holy Li Shizhen (1518-1593 A.D.) Compendium of Material Medica of Ming Dynasty's medicine has done to study in great detail most record to its property of medicine, consumption.Flourish youth's work " revise and enlarge with Chinese medicine and examine " of the pharmacists Junichiro Koizumi of Japan is also on the books.The food additive scope is formally classified native gold as in the 16 meeting of food additive regulations committee of nineteen eighty-three World Health Organization (WHO) (WHO) (CCFA) (Hague, Detch meeting), classifies A table the as No. 310.
Nanometer gold has very strong adsorption function to protein, DNA etc., and can not change the character of adsorbed material, and the antibiotic property of nano gold sol, safety, toxicity have been passed through FDA (Food and Drug Adminstration) (FDA) authentication.The nanometer gold pharmaceutical carrier good as character studied widely and applied, and nanometer gold can play the effect of carrying the active component Transdermal absorption, thereby improves the absorption of skin to effective ingredient.
Studies have found that nanometer gold has the promotion cell proliferation, the function enhanced metabolism more.The inventor also finds that nanometer gold all can promote cell proliferation to the human skin cell in the finite concentration scope, has dose dependent and time dependence, and on cell proliferation shows as the significance facilitation and, along with the increase of time, promotes multiplication capacity to strengthen.
Along with age ageing, visual appearance, physical characteristic and the physiological function of Long Term Contact adverse environmental factors or malnutrition skin change, and are considered on cosmetology not expected.Often show as clinically that pachylosis, drying, sensitivity and fragility increase, cutis laxa, elasticity reduce, wrinkle increases, atrophoderma, corium transparency increase and make skin shinny, but generally can maintain its whole geometry graphical appearance, often is canescence.These are the hypometabolism with the aging of age all, and Long Term Contact adverse environmental factors or malnutrition have close relationship.
Preventing in advance skin aging and the wrinkle that goes down is the eternal problem of cosmetics research and development.
Because the outermost horny layer of skin itself has as defence from external allotrylic barrier physiological function, so just simply relevant functional components is fitted in external preparation, be can not obtain abundant Transdermal absorption, can not show the original effect of this composition.Used in recent years the Percutaneous absorption enhancers such as dimethyl sulfoxine, dimethyl formamide, dimethyl acetamide, methyl decyl sulfoxide, purpose is to improve the percutaneous absorbability of various materials.Yet these Percutaneous absorption enhancers do not provide satisfied Transdermal absorption facilitation effect, and due to erythema etc. is appearred by force and sometimes in skin irritation on skin, so, in its effect, safety, use, be not desirable especially.
In order to improve the functional of functional type cosmetics, need to continue development effectiveness good and there is no a functional cosmetics compositions of negative interaction.
Nanometer gold also has been used in cosmetics, for example: Chinese patent: application number 200810045539.3 disclosed " a kind of preparation method of eye-care cosmetic " has proposed a kind of formula and preparation method of the eye-care cosmetic that contains nanometer gold.
The inventor finds, because nanometer gold self can promote the metabolism of skin, and can promote the Transdermal absorption of other functional components, nanometer gold, for the compositions of the high-energy of skin metabolism source and/or victory peptide class, one or more antioxidants in nursing with improve aging, malnutrition or be subject to and show synergism characteristic aspect the skin of environmental nuisance.
Summary of the invention
The present invention is by a kind of cosmetic water that contains nanometer gold and preparation method are provided, for nursing with improve aging, malnutrition or be subject to the skin of environmental nuisance that a kind of unique combination thing is provided.
Described compositions contains: nanometer gold, for the high-energy of skin cell metabolism source and/or victory peptide class, one or more antioxidants.The wherein form configuration by the beauty treatment mixture by compositions.
Nanometer gold is originated and/or victory peptide class and one or more antioxidant combination with the high-energy for skin cell metabolism, when nanometer gold self promotes cell metabolism, nanometer gold has also promoted the Transdermal absorption of other material in the compositions, and nanometer gold and between the high-energy of skin cell metabolism source and/or victory peptide class and antioxidant, producing synergism, thereby produced beyond thought beneficial effect.
A kind of cosmetic water of the present invention, its component formula is:
The A phase: the nano gold sol 13% that nanometer gold concentration is 400 μ mol/L, butanediol 5%, sodium hydrogen phosphate 0.5%, water are appropriate;
B phase: natural methyl propylhomoserin proline 0.5%, PHOSPHOVITAL
tM4%, ferulic acid 0.5%, fertility succinate 1%, rosmarinic acid 0.8%, Flos Inulae extract 0.5%, trehalose 0.5%, mucopolysaccharide (10%) 2%;
C phase: Anjidew NL50 0.1%, MEIGUI CHUNLU 0.05%, Sargassum extract 0.1%, phenoxyethanol 0.1%;
The preparation method of described cosmetic water is: under the state stirred in appropriateness, heat respectively A phase and B to 65 ℃, after stirring, by B be added to A mutually in, and continue to stir the gained mixture, until mix homogeneously, then described mixture is cooled to 40 ℃, and C is added to, be stirred to mix homogeneously, be cooled to 35 ℃, obtain.
Compositions of the present invention can be included in cosmetic carrier.Cosmetic carrier can comprise emulsion, cream frost, washing liquid, solution, gel or ointment, or any other carrier well known by persons skilled in the art.In aspect concrete, emulsion can be emulsion oil-in-water or water-in-oil emulsion.Solution of the present invention can be, for example: aqueous solution or water-alcohol solution.Anhydrous base material can be lip pomade or powder.
Aspect other indefiniteness, compositions of the present invention can be included in aging products or humidification product, or is designed to provide in any product of benefit to skin.In concrete aspect, compositions can be applicable to during use using one day at least one times, twice, three times, four times, five times or more times.Compositions can also be chemical compatibility.
According to the present invention, described compositions contains such as the lactobacillus ferment, the wheat protein of hydrolysis, glycine, this class of arginine and methionine is for the high-energy source of skin cell metabolism, and the victory peptide class that described compositions contains is selected from: two victory peptides, palmitoyl tripeptide 3, four victory peptides, Wushengtai, Argireline, seven victory peptides, eight victory peptides, nine victory peptides or their mixture, one or more antioxidants that described compositions contains are selected from: nicotiamide, vitamin A and derivant thereof, vitamin E and derivant thereof, ascorbic acid, magnesium ascorbyl phosphate, sodium ascorbate, the ascorbic acid polypeptide, the ascorbyl dipalmitate, methyl silicane alcohol ascorbic acid, the ascorbyl stearate, ascorbic acid tocopherol potassium phosphate, cysteine, tocopherol and derivant thereof, ferulic acid, epicatechol gallate, gallateoctylester, propyl gallate, PGS, tocopherol acetas, Vitamin E linoleate, tocopheryl nicotinate, the fertility succinate, rosmarinic acid, superoxide dismutase, catalase, glutathione peroxidase, metallothionein, Fructus Chaenomelis sulfydryl enzyme, coenzyme Q10 or their mixture.
This cosmetic composition can comprise by weight of the composition 0.01% to 30%, preferably 0.1% to 9% the high-energy for skin cell metabolism source and/or victory peptide class; Compositions comprises by weight of the composition 0.05% to 20%, preferably one or more antioxidants of 0.1 to 9%.
The present composition is for improving skin vision outward appearance, physiologic function or the biophysics's characteristic that is subject to many factors and changes.For example age ageing, long-term Exposure to Sunlight, adverse environment condition of said factors wherein, such as pollutant, family apply some make up, disease pathological changes, smoking or underfed factor.Wherein the variation of said visual appearance comprises, for example, the appearance of microgroove and wrinkle, depression increase, loss of elasticity, fecundity loses and the forfeiture of color and luster uniformity, coarse texture, mottled pigmentation, and its these and other aspect of the present invention is done below further and described in detail.
The A nanometer gold
Studies have found that nanometer gold has the promotion cell proliferation more, the function enhanced metabolism, the inventor also finds that nanometer gold also all can promote cell proliferation to the human skin cell in the finite concentration scope, there is dose dependent and time dependence, on cell proliferation shows as the significance facilitation and along with the increase of time, promote multiplication capacity to strengthen, nanometer gold is on not impact of cancerous cell simultaneously, and the age of copying life time and donor of fibroblast in-vitro multiplication ability detection all ages and classes human skin fibroblast is negative correlation, the replication in vitro life time of one-year-old its cell of every increase of donor age reduced for 0.2 generation.
Nanometer gold self can promote the metabolism of skin, can promote the Transdermal absorption of other functional components, the compositions of the high-energy of nanometer gold, skin metabolism source and/or victory peptide class, one or more antioxidants is in nursing and improve aging, malnutrition or be subject to and show synergism characteristic aspect the skin of environmental nuisance.
B is for the high-energy source of skin cell metabolism
In typical embodiment, described high-energy source comprises the lactobacillus ferment.In specific embodiment, origin the hang oneself phosphagen-derived molecules of microorganism of biotechnology modified in described high-energy source forms.It is comprised of wheat protein, glycine, arginine and the methionine of glycerol, lactobacillus ferment, hydrolysis.As embodiment, this energy source can trade name PHOSPHOVITAL
tMbe commercially available, on sale in French Si Dama company.This material provides the high-energy source for skin cell metabolism.The working concentration of this material in formula is more than 0.05% to 30% or 30%.
The C antioxidant
Antioxidant is during a class can help to catch also and free radical, thereby dispels a class material of radical pair human body infringement.Radical reaction is to cause an old and feeble key factor, and scientist is by experimental results demonstrate that free-radical oxidation is the major reason that causes aging, cell injury and degeneration.Free radical is that a class is present in the harmful substance that can damage cell in body cell.In a kind of biological chain type course of reaction in body, the existence of free radical impels the interior old and feeble materials such as melanin, lipofuscin and ceroid that produce of skin histology.Biological itself have defence capability to free radical, but this ability increases along with the age and progressively goes down, the active attenuating.
The D cosmetic carrier
Compositions of the present invention is all effective in all types of cosmetic carrier.The indefiniteness embodiment of suitable cosmetic carrier comprises emulsion, cream, washing liquid, solution (moisture and water-alcohol), anhydrous base material (as, lip pomade and powder), gel and ointment, perhaps by other method or aforesaid any combination, as those skilled in the art can know, change with other suitable carriers apparent to those skilled in the art being suitable for and use in the present invention.
In preferred embodiments, cosmetic carrier is selected from emulsion oil-in-water, the encapsulate pearl in water-ol solution or anhydrous system.With regard to emulsion oil-in-water, this emulsion and composition and production method be well known in the art.Yet, importantly select concentration and the combination of compound and extract, combination is that chemical is compatible, and does not form complex and precipitate from finished product.
The E beautification product
Compositions of the present invention can also, for a lot of beautification products, include but not limited to humidification cream, beneficial skin cream and washing liquid, gel, ointment, foundation cream, late frost, lip pomade, cleaning agent, toner, facial film and/or colored beautification product.Compositions is first-selected for aging products, for face and other body parts, the most particularly stays the product on skin.
Other compound and reagent that F can be used together with the present invention's combination
Compositions of the present invention can contain other beneficial agents and compound, and for example, acute or chronic humidizer (comprises, for example, wetting agent, occludent and the reagent that affects the natural humidification mechanism of skin), plant extract, antioxidant, skin whitener is (for example, hydroquinone), emollient, counter-stimulus, vitamin, trace metal, antimicrobial, aromatic and/or dyestuff and coloring components.
The specific embodiment
Example 1 cosmetic water
Step: under the state that appropriateness stirs, heat respectively A phase and B to 65 ℃, after stirring, B is added to A mutually in and continue stirring gained mixture until mix homogeneously.Then described mixture is cooled to 40 ℃ and C is added to, is stirred to mix homogeneously, be cooled to 35 ℃.
Although illustrative embodiment of the present invention has been enclosed in above description, certainly should be understood that, those skilled in the art obviously can carry out various improvement.
Claims (2)
1. a cosmetic water, it is characterized in that: the component formula is:
The A phase: the nano gold sol 13% that nanometer gold concentration is 400 μ mol/L, butanediol 5%, sodium hydrogen phosphate 0.5%, water are appropriate;
B phase: natural methyl propylhomoserin proline 0.5%, PHOSPHOVITAL
tM4%, ferulic acid 0.5%, fertility succinate 1%, rosmarinic acid 0.8%, Flos Inulae extract 0.5%, trehalose 0.5%, mucopolysaccharide (10%) 2%;
C phase: Anjidew NL50 0.1%, MEIGUI CHUNLU 0.05%, Sargassum extract 0.1%, phenoxyethanol 0.1%;
The preparation method of described cosmetic water is: under the state stirred in appropriateness, heat respectively A phase and B to 65 ℃, after stirring, by B be added to A mutually in, and continue to stir the gained mixture, until mix homogeneously, then described mixture is cooled to 40 ℃, and C is added to, be stirred to mix homogeneously, be cooled to 35 ℃, obtain.
2. a method for preparing cosmetic water claimed in claim 1, it is characterized in that: under the state stirred in appropriateness, heat respectively A phase and B to 65 ℃, after stirring, by B be added to A mutually in, and continue to stir the gained mixture, until then mix homogeneously is cooled to 40 ℃ by described mixture, and C is added to, be stirred to mix homogeneously, be cooled to 35 ℃, obtain.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110244777 CN102440943B (en) | 2011-08-25 | 2011-08-25 | Composition for caring and improving aged or damaged skin |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110244777 Division CN102440943B (en) | 2011-08-25 | 2011-08-25 | Composition for caring and improving aged or damaged skin |
Publications (2)
| Publication Number | Publication Date |
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| CN103479551A true CN103479551A (en) | 2014-01-01 |
| CN103479551B CN103479551B (en) | 2015-10-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310455371.4A Active CN103479552B (en) | 2011-08-25 | 2011-08-25 | Crease-resistant easypro eye cream alive and preparation method |
| CN 201110244777 Active CN102440943B (en) | 2011-08-25 | 2011-08-25 | Composition for caring and improving aged or damaged skin |
| CN201310455248.2A Active CN103479551B (en) | 2011-08-25 | 2011-08-25 | Cosmetic water and preparation method |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310455371.4A Active CN103479552B (en) | 2011-08-25 | 2011-08-25 | Crease-resistant easypro eye cream alive and preparation method |
| CN 201110244777 Active CN102440943B (en) | 2011-08-25 | 2011-08-25 | Composition for caring and improving aged or damaged skin |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102440943B (en) | 2013-09-11 |
| CN103479552B (en) | 2015-10-21 |
| CN103479552A (en) | 2014-01-01 |
| CN103479551B (en) | 2015-10-21 |
| CN102440943A (en) | 2012-05-09 |
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