CN105326651A - Mouthwash and preparation method thereof - Google Patents

Mouthwash and preparation method thereof Download PDF

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CN105326651A
CN105326651A CN 201510815638 CN201510815638A CN105326651A CN 105326651 A CN105326651 A CN 105326651A CN 201510815638 CN201510815638 CN 201510815638 CN 201510815638 A CN201510815638 A CN 201510815638A CN 105326651 A CN105326651 A CN 105326651A
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parts
mouthwash
menthol
ws
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CN 201510815638
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CN105326651B (en )
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卜允利
高宇
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合肥九研医药科技开发有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24Thermal properties
    • A61K2800/244Endothermic; Cooling; Cooling sensation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/522Antioxidants; Radical scavengers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/524Preservatives

Abstract

The invention discloses mouthwash. The mouthwash comprises components in parts by weight as follows: 0.01-10 parts of WS-23 by weight, 0.01-50 parts of menthol by weight, 1-300 parts of a dispersing agent by weight, 0.01-10 parts of a surfactant by weight, 0.01-300 parts of a sweetening agent by weight, 0.5-1 part of a preservative by weight, 0.5-1 part of essence by weight and 800-1000 parts of purified water by weight. A preparation method of the mouthwash comprises steps as follows: the menthol is crushed at the low temperature, and the particle size D90 value is smaller than 380 mu m; menthol powder, WS-23 and polysorbate are added to glycerin, and an oil-phase solution is prepared through stirring; the sweetening agent, the preservative and the essence are added to water and stirred, and an aqueous-phase solution is prepared; the oil-phase solution is added to the aqueous-phase solution, and the mouthwash is obtained through stirring. The mouthwash has the advantages that the cooling feeling can last for a long time and is rich; a fresher and more lasting aroma can be produced; the mouthwash is edible.

Description

_种漱口水及其制备方法【技术领域】 _ Species mouthwash and preparation method thereof FIELD

[0001] 本发明涉及食品日化领域,具体地说是涉及一种漱口水及其制备方法。 [0001] The present invention relates to the field of food daily, and particularly relates to a method for preparing aqueous mouthwash. 【背景技术】 【Background technique】

[0002] 以往人们认为早晚刷牙就可达到卫生标准了,可就口腔卫生新理念来讲却远远不够。 [0002] It is believed that sooner or later, brushing past can meet health standards, and may make oral hygiene a new concept in terms is far from enough. 专家提出:清洁口腔像洗手一样必需。 Experts: clean mouth like hand washing as necessary. 漱口是口腔保健最方便易行的方法,它能去除口腔内的食物残渣和部分软垢,还能暂时减少口腔内细菌的数量。 Mouthwash oral health is the method most convenient and easy, it can remove food debris in the mouth and some debris, but also temporarily reduce the number of bacteria in the mouth. 随着人们口腔保健意识的增强,能够清新口气保护牙齿的漱口水受到越来越多人的青睐。 As people's awareness of oral health, it can protect the fresh breath mouthwash teeth more and more people of all ages. 漱口水分为保健性和治疗性两大类。 Rinse water for the care and treatment of the two categories. 保健性漱口水一般口感相对较好,主要成分是口腔清新剂,用于去除口臭,因此无需特殊指导,使用人群也无限制。 Mouthwash relatively good health of the general taste of water, the main component is a breath freshener, used to remove bad breath, so no special instructions, using crowd unlimited. 但治疗性漱口水含有洗必泰、复合碘剂等消炎、杀菌的药物成分,是不可以随便使用的。 However, the therapeutic mouthwashes containing chlorhexidine, iodine and other anti-inflammatory compound, bactericidal drug ingredient, should not be arbitrarily used. 这种类型的漱口水可以预防和控制牙周组织炎症,所以会用于牙周病、口腔黏膜病的辅助性治疗。 This type of mouthwash can prevent and control periodontal tissue inflammation, it will be for periodontal disease, oral mucosal adjuvant treatment of disease.

[0003] 不论是保健型还是治疗型漱口水,口感都非常重要。 [0003] Whether or health-treatment mouthwash, taste is very important. 保健型漱口水,主要是起到清新口气的作用,对口感的要求更高;治疗性漱口水如果口感不良,会引起使用者的使用抵触,进而排斥使用。 Health mouthwash, mainly played the role of fresh breath, more demanding taste; if therapeutic mouthwash taste bad, can cause the user to use conflict, and then exclude use. 而且现在市场上销售的漱口水的成分复杂,一般只是建议漱口后吐出, 不建议食用;为了达到漱口水的新鲜口气的效果,是通过添加多种清凉剂的组合物来增加清凉感,清凉剂中有水溶性的,亦有脂溶性的,通常为了更好的加入清凉剂,漱口水中多加入乙醇,但是含有乙醇的漱口水不适合儿童和驾驶员使用。 And now mouthwash component complex on the market, generally only recommendations swished and expectorated not recommended for consumption; in order to achieve the effect of fresh breath mouthwash, by adding more cooling agent to increase the cool feeling composition, cool a water-soluble agent, also fat-soluble, generally added in order to better cooling agent, mouthwash multi ethanol was added ethanol containing mouthwashes but not suitable for children and the driver uses. 在漱口水中不使用乙醇的情况下,保证多种清凉剂的组合物在漱口水中的稳定性,以及清凉剂在持久性是个新的问题。 In the case where no ethanol mouthwash to ensure that the cooling agent compositions in a variety of mouthwash stability and persistence in the cooling agent is a new problem. 【发明内容】 [SUMMARY]

[0004] 为保证多种清凉剂的组合物在漱口水中的稳定性,以及清凉剂在持久性,本发明提供一种漱口水,该漱口水可以显著改善清凉口感,使口腔具有持续的清爽感,而且该漱口水在多种环境下均具有很好的稳定性。 [0004] To ensure the compositions of the cooling agent in a mouthrinse the stability and persistence in the cooling agent, the present invention provides a mouthwash, mouthwash which can significantly improve cool mouthfeel that has sustained oral refreshing sense, and the environment in a variety of mouthwash has good stability.

[0005] 本发明是通过以下技术方案来达到目的: [0005] The object of the present invention is achieved by the following technical solutions:

[0006] -种漱口水,有以下成分按重量份组成:WS_23 :0.01~10重量份、薄荷脑: 0.01~50重量份、分散剂:1~300重量份、表面活性剂:0.01~10重量份、甜味剂:0.01~ 300重量份、防腐剂:0. 5~1重量份、香精:0. 5~1重量份、纯净水:800~1000重量份 [0006] - species mouthwash, the following ingredients in parts by weight composition: WS_23: 0.01 ~ 10 parts by weight menthol: 0.01 to 50 parts by weight, a dispersing agent: 1 to 300 parts by weight of surfactant: from 0.01 to 10 wt. parts, sweeteners: 0.01 to 300 parts by weight, a preservative: 05 to 1 parts by weight, flavor: 05 to 1 parts by weight of pure water: 800 to 1000 parts by weight

[0007] 优选的,一种漱口水,有以下成分按重量份组成:WS-23 :0. 1~10重量份、薄荷脑: 0. 1~20重量份、甘油:10~100重量份、聚山梨酯:0. 1~10重量份、甜味剂:0. 1~50重量份、防腐剂:〇. 5~1重量份、香精:0. 5~1重量份、纯净水:800~1000重量份。 [0007] Preferably, a method of mouthwash, the following ingredients in parts by weight composition: WS-23: 01 to 10 parts by weight menthol: 0.1 to 20 parts by weight Glycerin: 10 parts by weight to 100, polysorbate: 01 to 10 parts by weight, sweetener: 01 to 50 parts by weight, a preservative: 5 to 1 billion parts by weight, flavor: 05 to 1 parts by weight of pure water: 800 ~ 1000 parts by weight.

[0008] 所述漱口水还含有以下重量份成分:壳聚糖10~40重量份。 [0008] The mouthwash composition further comprising the following weight parts: 10 to 40 parts by weight of chitosan.

[0009] WS-23即N,2, 3-三甲基-2-异丙基丁酰胺是一种品质很好的凉味剂,具有较高的凉味活性而没有灼烧、麻木和刺激等副作用,已被列入中国食品添加剂标准GB-2760中,可以安全使用。 [0009] WS-23 i.e. N, 2, 3- trimethyl-2-isopropyl butanamide is a good quality one kind of cooling agent has a high cool taste activity without burning, numbness and irritation and other side effects, has been included in Chinese food additive standards GB-2760 can be used safely.

[0010] 优选的,所述漱口水有以下成分按重量份组成:WS-23 :5重量份、薄荷脑:10重量份、甘油:50重量份、聚山梨酯:8重量份、甜味剂:30重量份、防腐剂:0. 6重量份、香精:0. 8 重量份、纯净水:850重量份。 [0010] Preferably, the mouthwash has the following composition by parts by weight composition: WS-23: 5 parts by weight menthol: 10 parts by weight Glycerin: 50 parts by weight, polysorbate: 8 parts by weight of a sweetener : 30 parts by weight, preservatives: 06 parts by weight, flavor: 08 parts by weight of pure water: 850 parts by weight.

[0011] 优选的,所述漱口水成分中分散剂为葡萄籽油。 [0011] Preferably, the dispersant component mouthwash is grape seed oil.

[0012] 优选的,所述漱口水成分中还含有以下重量份成分:壳聚糖10重量份。 [0012] Preferably, the mouthwash composition further contains the following parts by weight of the components: 10 parts by weight of chitosan.

[0013] 优选的,所述漱口水成分中的聚山梨酯还可以是蔗糖单月桂酸酯、山梨坦酯、聚甘油硬脂酸酯、聚氧乙烯失水山梨醇脂肪酸酯、杏树胶或卖泽的任一种。 [0013] Preferably, the polysorbate rinse water component may also be sucrose monolaurate, sorbitan esters, polyoxyethylene glyceryl stearate, polyoxyethylene sorbitan fatty acid esters, apricot gum or sell any of Ze.

[0014] 优选的,所述漱口水成分中的壳聚糖还可以是羟丙甲纤维素。 [0014] Preferably, the chitosan component mouthwash may also hypromellose.

[0015] -种漱口水的制备方法,包括如下步骤: [0015] - preparation methods mouthwash, comprising the steps of:

[0016] 步骤1 :将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ; [0016] Step 1: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um;

[0017] 步骤2 :将步骤1制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入甘油中, 充分搅拌制得油相溶液; [0017] Step 2: menthol powder prepared in Step 1, WS-23, polysorbate under stirring, glycerol, sufficiently stirred to prepare an oil phase solution;

[0018] 步骤3 :将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0018] Step 3: sweeteners, preservatives, flavors dissolved with stirring in purified water to prepare an aqueous phase solution;

[0019] 步骤4 :将制备好的油相溶液以0. 4~1.0 m/s的线速度加入到水相溶液中,以600~800转/min的速度搅拌30~50min,得漱口水。 [0019] Step 4: The oil phase solution was prepared to 0. 4 ~ 1.0 m / s linear velocity of the solution was added to the aqueous phase, at a rate of 600 to 800 revolutions / min was stirred 30 ~ 50min, to give mouthwash.

[0020] 优选的,所述步骤3 :将纯净水加热至50~60°C,加入壳聚糖,搅拌至完全溶解,冷却至室温,将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液。 [0020] Preferably, said Step 3: Purified water was heated to 50 ~ 60 ° C, chitosan was added and stirred until completely dissolved, cooled to room temperature, sweetening agent, preservatives, flavors purified water was added with stirring to dissolve to prepare aqueous solutions.

[0021] 本发明的优点是: [0021] The advantage of the present invention are:

[0022] (1)本发明的漱口水,使用WS-23和薄荷脑组合作为清凉剂,清凉感可持续较长, 凉感丰富;作用于整个口腔粘膜及喉部能产生更清新的、持久的香气; [0022] (1) of the present invention is a mouthwash, the use of a combination of menthol, WS-23 and as a cooling agent, persist for a long cool feeling, cool feeling rich; oral mucosa, and acting on the whole produce fresher throat, persistent aroma;

[0023] (2)本发明的漱口7尺,薄荷脑粉末,WS-23、聚山梨酯,加入甘油中搅拌,做成油相, 然后加入到水相中,搅拌可以得到有强稳定性的漱口水,而且可以使能薄荷脑和WS-23的复合清凉剂的清凉感柔和刺激性小,有效防止WS-23和薄荷脑的挥发,更适合大众口感,特别是适合儿童使用。 [0023] (2) according to the present invention, the 7-foot mouthwash, powder menthol, WS-23, polysorbate, glycerol was added with stirring to make an oil phase and then added to the aqueous phase, stirring can be obtained with a high stability mouthwash, but also enable menthol and refreshing sense of WS-23 composite freshener small soft irritation, effectively preventing the volatile menthol and WS-23 is more suitable for mass taste, especially suitable for children.

[0024] (3)本发明的漱口水的原料均为食品级,消费者在推荐量的情况下使用中可以食用,对健康没有危害。 Mouthwash [0024] (3) of the invention raw materials are food grade, consumers in the case of the recommended amount of use can be consumed without risk to health.

[0025] (4)本发明的漱口水中,成分中加入壳聚糖,不仅可以进一步增强漱口水的稳定性,还可以达到清凉剂缓释的作用,延长漱口水在口腔中清凉感时间。 [0025] (4) mouthrinse of the invention, the chitosan composition is added, not only to further enhance stability of mouthwash, refreshing agent can also achieve sustained release effect, extend the time mouthwash cool feeling in the mouth.

[0026] (5)本发明的漱口水中,成分中使用葡萄籽油作为分散剂,葡萄籽油含有丰富的不饱和脂肪酸,主要是油酸和亚油酸,其中亚油酸的含量高达72%~76%。 [0026] mouthwash (5) of the present invention, the component is used as a dispersant grape seed oil, grape seed oil rich in unsaturated fatty acids, mainly oleic and linoleic acids, the linoleic acid content of up to 72 to 76%. 葡萄籽油富含维生素E,具有较强的抗氧化性,能够有效地延长货架保质期,不易引起由于光照、热辐射和与空气接触而产生的氧化酸败现象;渗透力强,清爽不油腻,极易被口腔黏膜吸收。 Grape seed oil rich in vitamin E, has a strong antioxidant, can effectively extend the shelf life of the shelf, it is unlikely to cause oxidative rancidity phenomenon caused by light, heat and radiation generated by the contact with air; infiltration, fresh and not greasy, very easily sublingual administration. 【具体实施方式】 【detailed description】

[0027] 以下结合具体实施例对本发明作进一步说明: [0027] The following embodiments in conjunction with specific embodiments of the present invention is further described:

[0028] 漱口水中聚山梨酯、甘油加入量的考察: [0028] Polysorbate water rinse polysorbate, glycerol added in an amount of investigation:

[0029] WS-23 :5重量份、薄荷脑:10重量份、甜味剂:30重量份、防腐剂:0. 6重量份、香精:〇. 8重量份、纯净水:1000重量份; .. [0029] WS-23: 5 parts by weight menthol: 10 parts by weight of a sweetener: 30 parts by weight, preservatives: 06 parts by weight, flavor: 8 billion parts by weight of pure water: 1000 parts by weight;

[0030] 将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ; 将制备的薄荷脑粉末,甜味剂、防腐剂、香精加入纯净水中溶解搅拌,以600~800转/min 的速度搅拌30~50min,得基础漱口水。 [0030] The menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; powders prepared menthol, sweeteners, preservatives, flavors dissolved purified water was added with stirring, speed rpm / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash base.

[0031] 取制得的基础漱口水,分等量的6份,分别添加甘油至浓度为0、5、10、20、50、 lOOmg/lOOml,测试并记录凉味剂持续时间; [0031] Take the resulting mouthwash base, 6 parts of points equal amount of glycerol were added to a concentration of 0,5,10,20,50, lOOmg / lOOml, test and record the duration of cooling agents;

[0032] 甘油用量与凉味剂持续时间关系列表 [0032] The relationship between duration and amount of glycerol list cooling agents

Figure CN105326651AD00051

[0034] 取制得的基础漱口水,分等量的7份,分别添加聚山梨酯至浓度为0、0. 1、5、10、 50、100、150mg/100ml,测试并记录凉味剂持续时间; [0034] The resulting base taken mouthwash, an equivalent amount of 7 parts by points, Polysorbate were added to a concentration of 0,0. 1,5,10, 50,100,150mg / 100ml, and the test recording cooling agents duration;

[0035] 聚山梨酯用量与凉味剂持续时间关系列表 [0035] The duration of the time listing the amount of polysorbate and cooling agents

Figure CN105326651AD00052

[0037] 漱口水配方的研究 Studies [0037] mouthwash recipe

[0038] 称取WS-23、薄荷脑、聚山梨酯、甘油、甜味剂、防腐剂、香精、纯净水;按以下方法制备:将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ;将制备的薄荷脑粉末,WS-23、聚山梨酯、搅拌的条件下加入甘油中,充分搅拌制得油相溶液; [0038] Weigh WS-23, menthol, polysorbate, glycerol, sweeteners, preservatives, flavors, purified water; prepared as follows: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; glycerin added powder prepared under menthol, WS-23, polysorbate, stirring conditions, sufficiently stirred to prepare an oil phase solution;

[0039] 将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0039] The sweetening agent, preservatives, flavors dissolved with stirring in purified water to prepare an aqueous phase solution;

[0040] 将制备好的油相溶液缓缓加入搅拌中的水相溶液中,控制线速度0. 4~1.0 m/s, 以600~800转/min的速度搅拌30~50min,得漱口水。 [0040] The prepared oil phase was added slowly to a stirred solution of the aqueous phase, the control linear velocity 0. 4 ~ 1.0 m / s, at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash .

[0041] 通过调整WS-23、聚山梨酯、甘油的浓度,进行正交设计,来考察凉味剂持续时间: [0041] By adjusting, polysorbate, glycerol concentration of WS-23, orthogonal design to examine the duration of cooling agents:

[0042] 三种组分影响因素的正交实验设计和实验结果 [0042] The orthogonal design and experimental results of the three component factors

[0043] [0043]

Figure CN105326651AD00061

[0044] 由实验结果可知,各因素主次排列为,甘油〉聚山梨酯〉WS-23,试验的最优水平组合为甘油:50、聚山梨酯:10、WS-23 :6。 [0044] From the experimental results, each of the primary and secondary elements are arranged, glycerol> polysorbate> WS-23, a combination of the optimal level of glycerol Test: 50, polysorbate: 10, WS-23: 6.

[0045] 实施例一: [0045] Example a:

[0046] 称取WS-23 :0. 1重量份、薄荷脑:0. 1重量份、聚山梨酯:0. 1重量份、甘油:10重量份、甜味剂:100重量份、防腐剂:0. 5重量份、香精:1重量份、纯净水:800重量份; [0046] Weigh WS-23:. 0 1 parts by weight menthol: 01 parts by weight, polysorbate: 01 parts by weight Glycerin: 10 parts by weight of a sweetener: 100 parts by weight of a preservative : 05 parts by weight, flavor: 1 parts by weight of pure water: 800 parts by weight;

[0047] 制备:将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ;将制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入甘油中,充分搅拌制得油相溶液; [0047] Preparation: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; Add the menthol powder prepared, WS-23, polysorbate stirring conditions glycerol, sufficiently stirred to prepare an oil phase solution;

[0048] 将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0048] The sweetening agent, preservatives, flavors dissolved with stirring in purified water to prepare an aqueous phase solution;

[0049] 将制备好的油相溶液缓缓加入搅拌中的水相溶液中,控制线速度0. 4~1.0 m/s, 以600~800转/min的速度搅拌30~50min,得漱口水。 [0049] The prepared oil phase was added slowly to a stirred solution of the aqueous phase, the control linear velocity 0. 4 ~ 1.0 m / s, at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash .

[0050] 实施例二: [0050] Example II:

[0051] 称取WS-23 :1重量份、薄荷脑:1重量份、聚山梨酯:1重量份、甘油:10重量份、甜味剂:100重量份、防腐剂:0. 5重量份、香精:1重量份、纯净水:800重量份; [0051] Weigh WS-23: 1 parts by weight menthol: 1 parts by weight, Polysorbate: 1 parts by weight Glycerin: 10 parts by weight of a sweetener: 100 parts by weight of preservatives: 05 parts by weight , flavors: 1 parts by weight of pure water: 800 parts by weight;

[0052] 制备:将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ;将制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入甘油中,充分搅拌制得油相溶液; [0052] Preparation: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; Add the menthol powder prepared, WS-23, polysorbate stirring conditions glycerol, sufficiently stirred to prepare an oil phase solution;

[0053] 将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0053] The sweetening agent, preservatives, flavors dissolved with stirring in purified water to prepare an aqueous phase solution;

[0054] 将制备好的油相溶液缓缓加入搅拌中的水相溶液中,控制线速度0. 4~1.0 m/s, 以600~800转/min的速度搅拌30~50min,得漱口水。 [0054] The prepared oil phase was added slowly to a stirred solution of the aqueous phase, the control linear velocity 0. 4 ~ 1.0 m / s, at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash .

[0055] 实施例三: [0055] Example III:

[0056] WS-23 :5重量份、薄荷脑:10重量份、聚山梨酯:8重量份、甘油:50重量份、甜味剂:30重量份、防腐剂:0. 6重量份、香精:0. 8重量份、纯净水:850重量份; [0056] WS-23: 5 parts by weight menthol: 10 parts by weight, polysorbate: 8 parts by weight Glycerin: 50 parts by weight of a sweetener: 30 parts by weight, preservatives: 06 parts by weight, flavor : 08 parts by weight of pure water: 850 parts by weight;

[0057] 制备:将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ;将制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入甘油中,充分搅拌制得油相溶液; [0057] Preparation: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; Add the menthol powder prepared, WS-23, polysorbate stirring conditions glycerol, sufficiently stirred to prepare an oil phase solution;

[0058] 将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0058] The sweetening agent, preservatives, flavors dissolved with stirring in purified water to prepare an aqueous phase solution;

[0059] 将制备好的油相溶液缓缓加入搅拌中的水相溶液中,控制线速度0. 4~1.0 m/s, 以600~800转/min的速度搅拌30~50min,得漱口水。 [0059] The prepared oil phase was added slowly to a stirred solution of the aqueous phase, the control linear velocity 0. 4 ~ 1.0 m / s, at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash .

[0060] 实施例四: [0060] Example IV:

[0061] 称取WS-23 :10重量份、薄荷脑:20重量份、聚山梨酯:10重量份、甘油:100重量份、甜味剂:300重量份、防腐剂:1重量份、香精:0. 5重量份、纯净水:1000重量份; [0061] Weigh WS-23: 10 parts by weight menthol: 20 parts by weight, polysorbate: 10 parts by weight of glycerol: 100 parts by weight of a sweetener: 300 parts by weight of a preservative: 1 parts by weight, flavor : 05 parts by weight of pure water: 1000 parts by weight;

[0062] 制备:将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ;将制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入甘油中,充分搅拌制得油相溶液; [0062] Preparation: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; Add the menthol powder prepared, WS-23, polysorbate stirring conditions glycerol, sufficiently stirred to prepare an oil phase solution;

[0063] 将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0063] The sweetening agent, preservatives, flavors dissolved with stirring in purified water to prepare an aqueous phase solution;

[0064] 将制备好的油相溶液缓缓加入搅拌中的水相溶液中,控制线速度0. 4~1.0 m/s, 以600~800转/min的速度搅拌30~50min,得漱口水。 [0064] The prepared oil phase was added slowly to a stirred solution of the aqueous phase, the control linear velocity 0. 4 ~ 1.0 m / s, at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash .

[0065] 实施例五: [0065] Example Five:

[0066] WS-23 :5重量份、薄荷脑:10重量份、聚山梨酯:8重量份、甘油:50重量份、壳聚糖:15重量份、甜味剂:30重量份、防腐剂:0. 6重量份、香精:0. 8重量份、纯净水:850重量份; [0066] WS-23: 5 parts by weight menthol: 10 parts by weight, polysorbate: 8 parts by weight Glycerin: 50 parts by weight of chitosan: 15 parts by weight of a sweetener: 30 parts by weight, a preservative . 06 parts by weight, flavor:: 08 parts by weight of pure water: 850 parts by weight;

[0067] 制备:将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ;将制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入甘油中,充分搅拌制得油相溶液; [0067] Preparation: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; Add the menthol powder prepared, WS-23, polysorbate stirring conditions glycerol, sufficiently stirred to prepare an oil phase solution;

[0068] 将纯净水加热至50~60°C,加入壳聚糖,搅拌至完全溶解,冷却至室温,将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0068] Purified water was heated to 50 ~ 60 ° C, chitosan was added and stirred until completely dissolved, cooled to room temperature, sweetening agent, preservatives, flavors dissolved purified water was stirred to prepare an aqueous phase solution;

[0069] 将制备好的油相溶液缓缓加入搅拌中的水相溶液中,控制线速度0. 4~1.0 m/s, 以600~800转/min的速度搅拌30~50min,得漱口水。 [0069] The prepared oil phase was added slowly to a stirred solution of the aqueous phase, the control linear velocity 0. 4 ~ 1.0 m / s, at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash .

[0070] 实施例六: [0070] Example VI:

[0071] WS-23 :5重量份、薄荷脑:10重量份、甜味剂:30重量份、防腐剂:0. 6重量份、香精:〇. 8重量份、纯净水:850重量份; .. [0071] WS-23: 5 parts by weight menthol: 10 parts by weight of a sweetener: 30 parts by weight, preservatives: 06 parts by weight, flavor: 8 billion parts by weight of pure water: 850 parts by weight;

[0072] 将WS-23、薄荷脑、果糖、防腐剂、香精加入到纯净水中,搅拌均匀即可。 [0072] The WS-23, menthol, fructose, preservatives, flavors were added to the purified water, stirred evenly.

[0073] 实施例七: [0073] Example VII:

[0074] WS-23 :5重量份、薄荷脑:10重量份、聚山梨酯:8重量份、葡萄籽油:50重量份、壳聚糖:15重量份、甜味剂:30重量份、防腐剂:0. 6重量份、香精:0. 8重量份、纯净水:850重量份; [0074] WS-23: 5 parts by weight menthol: 10 parts by weight, polysorbate: 8 parts by weight, grape seed oil: 50 parts by weight of chitosan: 15 parts by weight of a sweetener: 30 parts by weight, . preservatives: 06 parts by weight, flavor: 08 parts by weight of pure water: 850 parts by weight;

[0075] 制备:将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um ;将制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入葡萄籽油中,充分搅拌制得油相溶液; [0075] Preparation: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; Add the menthol powder prepared, WS-23, polysorbate stirring conditions grape seed oil, and fully stirred to prepare an oil phase solution;

[0076] 将纯净水加热至50~60°C,加入壳聚糖,搅拌至完全溶解,冷却至室温,将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; [0076] Purified water was heated to 50 ~ 60 ° C, chitosan was added and stirred until completely dissolved, cooled to room temperature, sweetening agent, preservatives, flavors dissolved purified water was stirred to prepare an aqueous phase solution;

[0077] 将制备好的油相溶液缓缓加入搅拌中的水相溶液中,控制线速度0. 4~1.0 m/s, 以600~800转/min的速度搅拌30~50min,得漱口水。 [0077] The prepared oil phase was added slowly to a stirred solution of the aqueous phase, the control linear velocity 0. 4 ~ 1.0 m / s, at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, to give mouthwash .

[0078] 清凉口感持续时间测试实验: [0078] refreshing taste test experiment duration:

[0079] 分别取上述七个实施例中的七种漱口水,分别编号为①号-⑦号漱口水,随机请100名消费者试用四种漱口水,根据消费者的体验,记录清凉口感的持续时间,其中①号平均持续时间3. lmin、②号3. 5min、③号27. 3min、④号28. 5min、⑤号29. 6min、⑥号3. lmin、 ⑦号29. Imin;通过比照可以得出实施例二、三、四中的三种漱口水加入甘油、聚山梨酯可以显著增加清凉口感的持续时间;实施例五在加入甘油、聚山梨酯的基础上,再加入壳聚糖可以进一步增加清凉口感的持续时间;实施例五和实施例七相比,使用葡萄籽油代替甘油, 清凉口感的持续时间长,且受试者体验的清凉感更强。 [0079] Examples of the seven were taken seven embodiments mouthwash, mouthwash numbered as No. -⑦ ① number, please 100 consumers to try random mouthwash four kinds, according to the consumer experience, the recording cool taste duration, wherein the average duration ① No. 3. lmin, ② No. 3. 5min, ③ No. 27. 3min, ④ No. 28. 5min, ⑤ No. 29. 6min, ⑥ No. 3. lmin, ⑦ No. 29. Imin; by cf. can draw the second embodiment, the three forty-three kinds mouthwash glycerin, polysorbate can significantly increase the duration of refreshing taste; fifth embodiment in the addition of glycerol, based polysorbate on adding chitosan sugar may further increase the duration of refreshing taste; according to the fifth embodiment and compared to the seventh embodiment, the use of grape seed oil in place of glycerin, long duration of the refreshing taste, cooling sensation and experience stronger subject.

[0080] 清凉口感测试实验: [0080] refreshing taste test experiment:

[0081 ] 分别取上述实施例一、二、三、四,五中的五种漱口水,分别对应编号为①号、②号、 ③号、④号、⑤号,随机请100名消费者试用三种漱口水,投票选择口感最好的一种漱口水; 记录口感评价,其中①号15票、②号21票、③号52票、④号27票、⑤号58票,可得③号和⑤号漱口水的口感为更多消费者喜爱。 [0081] The above embodiments were collected one, two, three, four, five Fifth mouthwash, are numbered No. ①, ② number, No. ③, ④ number, number ⑤, 100 consumers to try random please three kinds of mouthwash, a vote for the best taste mouthwash; recording sensory evaluation, 15 votes wherein ①, ② 21 votes, 52 votes ③, ④ 27 votes, 58 votes ⑤, ③ number available and ⑤ number mouthwash taste love as more consumers.

[0082] 稳定性实验: [0082] Stability test:

[0083] 分别取上述五个实施例中的五种漱口水,分别编号为①号-⑦号漱口水,每种漱口水取样五份,四份样品密封放置在4°C、室温、40°C、6(TC的温度条件下留样1周,一份样品敞口放置在室温条件下留样一周,通过观察是否分层来考察漱口水的稳定性; [0083] each of the five embodiments taken five mouthwash, mouthwash numbered as No. -⑦ ① number, each mouthwash sample five, four samples were placed in a sealed 4 ° C, room temperature, 40 ° C, 6 (stability of the mouthrinse sample left for one week exposure of a sample left to stand at room temperature like a week to examine whether delamination by observing under a temperature condition of the TC;

[0084] 结果记录如下: [0084] The results are reported below:

[0085] [0085]

Figure CN105326651AD00091

[0086] 需要指出的是所有实施例均是做过多次的重复实验中,在重复实验中用分别用蔗糖单月桂酸酯、山梨坦酯、聚甘油硬脂酸酯、聚氧乙烯失水山梨醇脂肪酸酯、杏树胶或卖泽的任一种来等重量份代替聚山梨酯,同样的方法制备漱口水,制备的漱口水在清凉口感的持续时间、口感测试效果效果基本和使用聚山梨酯的漱口水一样,稳定性实验均没出现分层现象。 [0086] It is noted that all embodiments are done experiments repeated several times, the experiments were repeated using a sucrose monolaurate, sorbitan esters, polyoxyethylene glyceryl stearate, polyoxyethylene sorbitan sorbitan fatty acid esters, apricot gum or sell Ze any one place to other parts by weight of polysorbate, prepared in the same manner as mouthwash, mouthwash prepared in the duration of the refreshing taste, the taste test results and effects substantially poly Like mouthwash polysorbate, stability experiments were no stratification.

[0087] 用羟丙甲纤维素来代替壳聚糖,按实施例五制备漱口水,制备的漱口水在清凉口感的持续时间、口感测试效果效果基本和使用壳聚糖的漱口水一样,稳定性实验均没出现分层现象。 [0087] with hypromellose instead of chitosan, prepared as in Example five mouthwash, mouthwash prepared in the duration of the refreshing taste, the taste test results and effects substantially the same as chitosan mouthwash, stability experiments were no stratification.

Claims (9)

  1. 1. 一种漱口水,其特征在于:所述漱口水有以下成分按重量份组成:WS-23 :0. 01~10 重量份、薄荷脑:〇. 01~50重量份、分散剂:1~300重量份、表面活性剂:0. 01~10重量份、甜味剂:〇. 01~300重量份、防腐剂:0. 5~1重量份、香精:0. 5~1重量份、纯净水: 800~1000重量份。 A mouthwash, characterized in that: said mouthwash has the following composition by parts by weight composition: WS-23: 001 to 10 wt parts, menthol: 01 billion to 50 parts by weight, dispersing agent: 1 to 300 parts by weight of surfactant: 0 to 10 parts by weight 01, a sweetener: 01 to 300 billion parts by weight, a preservative: 05 to 1 parts by weight, flavor: 05 to 1 parts by weight, purified water: 800 to 1000 parts by weight.
  2. 2. 如权利要求1所述的漱口水,其特征在于,所述漱口水有以下成分按重量份组成: WS-23 :0. 1~10重量份、薄荷脑:0. 1~20重量份、甘油:10~100重量份、聚山梨酯: 0. 1~10重量份、甜味剂:0. 1~50重量份、防腐剂:0. 5~1重量份、香精:0. 5~1重量份、纯净水:800~1000重量份。 2. The mouthwash according to claim 1, wherein said mouthwash following ingredients in parts by weight composition: WS-23: 01 to 10 parts by weight menthol: 01 to 20 parts by weight glycerol: from 10 to 100 parts by weight, polysorbate: 0.1 to 10 parts by weight, sweetener: 01 to 50 parts by weight, a preservative: 05 to 1 parts by weight, flavor: 05 ~ 1 parts by weight of pure water: 800 to 1000 parts by weight.
  3. 3. 如权利要求2所述的漱口水,其特征在于:所述漱口水成分中还含有以下重量份成分:壳聚糖10~40重量份。 Mouthwash according to claim 2, wherein: said mouthwash composition further contains the following parts by weight of the components: 10 to 40 parts by weight of chitosan.
  4. 4. 如权利要求2所述的漱口水,其特征在于:所述漱口水有以下成分按重量份组成: WS-23 :5重量份、薄荷脑:10重量份、甘油:50重量份、聚山梨酯:8重量份、甜味剂:30重量份、防腐剂:〇. 6重量份、香精:0. 8重量份、纯净水:850重量份。 4. The mouthwash according to claim 2, wherein: said mouthwash composition has the following composition by parts by weight: WS-23: 5 parts by weight menthol: 10 parts by weight Glycerin: 50 parts by weight of polyethylene sorbitan ester: 8 parts by weight of a sweetener: 30 parts by weight, preservative: 6 billion parts by weight, flavor: 08 parts by weight of pure water: 850 parts by weight.
  5. 5. 如权利要求4所述的漱口水,其特征在于:所述漱口水成分中还含有以下重量份成分:壳聚糖10重量份。 5. The mouthwash according to claim 4, wherein: said mouthwash composition further contains the following parts by weight of the components: 10 parts by weight of chitosan.
  6. 6. 如权利要求1所述的漱口水,其特征在于:所述表面活性剂是蔗糖单月桂酸酯、山梨坦酯、聚甘油硬脂酸酯、聚氧乙烯失水山梨醇脂肪酸酯、杏树胶或卖泽的任一种。 6. The mouthwash according to claim 1, wherein: the surfactant is a sucrose monolaurate, sorbitan esters, polyoxyethylene glyceryl stearate, polyoxyethylene sorbitan fatty acid esters, apricot gum or sell any Ze.
  7. 7. 如权利要求3所述的漱口水,其特征在于:所述壳聚糖可以是羟丙甲纤维素。 7. The mouthwash according to claim 3, characterized in that: the chitosan may be hypromellose.
  8. 8. -种漱口水的制备方法,其特征在于:包括如下步骤: 步骤1 :将薄荷脑低温粉碎,粉碎温度不高于35°C,薄荷脑粉碎至粒径D90值小于380um; 步骤2 :将步骤1制备的薄荷脑粉末,WS-23、聚山梨酯搅拌的条件下加入甘油中,充分搅拌制得油相溶液; 步骤3 :将甜味剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液; 步骤4 :将制备好的油相溶液以0. 4~1.Om/s的线速度加入到水相溶液中,以600~ 800转/min的速度搅拌30~50min,得漱口水。 8. - mouthwash preparation methods, characterized by: comprising the following steps: Step 1: menthol cryogenic grinding, grinding temperature not higher than 35 ° C, menthol pulverized to a particle size D90 value of less than 380um; Step 2: menthol powder prepared in step 1, WS-23, polysorbate under stirring, glycerol, sufficiently stirred to prepare an oil phase solution; step 3: sweeteners, preservatives, flavors dissolved purified water was added with stirring, prepare an aqueous phase solution; step 4: the oil phase solution was prepared at 0.4 / ~ 1.Om s linear velocity is added to the aqueous phase solution at a rate of revolutions / min 600 to 800 was stirred 30 ~ 50min, It was mouthwash.
  9. 9. 如权利要求7所述的制备方法,其特征在于:所述步骤3 :将纯净水加热至50~ 60°C,加入壳聚糖,搅拌至完全溶解,冷却至室温,将甜味剂、分散剂、防腐剂、香精加入纯净水中溶解搅拌,制得水相溶液。 9. The method as recited in claim 7, wherein: said Step 3: Purified water was heated to 50 ~ 60 ° C, chitosan was added and stirred until completely dissolved, cooled to room temperature, sweetening agent , stirring to dissolve the dispersant, a preservative, a flavor was added purified water to prepare aqueous solutions.
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