CN113576961A - Agilawood toothpaste and preparation method thereof - Google Patents
Agilawood toothpaste and preparation method thereof Download PDFInfo
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- CN113576961A CN113576961A CN202110816723.9A CN202110816723A CN113576961A CN 113576961 A CN113576961 A CN 113576961A CN 202110816723 A CN202110816723 A CN 202110816723A CN 113576961 A CN113576961 A CN 113576961A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Abstract
The invention discloses agilawood toothpaste, which comprises, by weight, 10-60 parts of an abrasive, 30-50 parts of a humectant, 0.5-2 parts of a thickener, 1-3 parts of a foaming agent, 0.1-5 parts of a functional agent and 0.2-3 parts of water, wherein the functional agent comprises an agilawood extract and an anti-allergic agent, and the agilawood extract is one or two of an agilawood leaf extract and an agilawood flower extract which are mixed in any proportion; the antiallergic agent comprises baking soda, amelogenin extract and calcium phosphate. The invention also discloses a preparation method of the agilawood toothpaste. The agilawood toothpaste can inhibit porphyromonas gingivalis and klebsiella pneumoniae in the oral cavity of a smoker, and can prevent tooth allergy and dental caries.
Description
Technical Field
The invention relates to the field of daily chemical processing, and particularly relates to agilawood toothpaste and a preparation method thereof.
Background
Toothpaste is a common oral cleaning product in daily life. The main components comprise abrasive, humectant, thickener, foaming agent, aromatic, water and other additives (including functional components for improving oral health). The basic function of the toothpaste is as follows: the toothpaste has the advantages of reducing tartar with lower hardness, reducing generation of dental plaque, reducing stains on the surfaces of teeth, keeping fresh breath for a long time, refreshing mouth feel in the oral cavity, cleaning the oral cavity, whitening the teeth, maintaining the health of teeth and periodontal tissues (including gingiva) for a long time and keeping the oral health for a long time. The mode of action of the toothpaste mainly has three aspects: 1. physical mode, 2. chemical mode, 3. biological mode. Physical aspect: the toothbrush is matched with the abrasive in the toothpaste to clean adhesive substances on teeth and keep the oral cavity clean. In the chemical aspect: the surfactant in the toothpaste decomposes and dissolves dental plaque and tartar on teeth, so that the aromatic in the toothpaste keeps the oral cavity fresh, thereby achieving the purpose of cleaning teeth and oral cavity. In the biological aspect: the effective components in the toothpaste can inhibit or kill harmful bacteria in oral cavity, thereby maintaining oral health.
Patent CN202011021922.2 discloses an agalloch eaglewood toothpaste, and discloses that the agalloch eaglewood toothpaste prepared by using aloeswood as a raw material can eliminate peculiar smell in the oral cavity, has a good antibacterial effect, inhibits bacterial growth, reduces oral problems such as oral ulcer, mucosal injury, gingival inflammation and gall, and also has health-care effects of protecting and strengthening teeth. Modern researches show that the agilawood leaf contains volatile oil, flavone and glycosides thereof, phenols, triterpenes, polysaccharides and amino acids, and the chemical components have multiple physiological activities of resisting inflammation, relieving pain and the like. The aquilaria sinensis leaves and the aquilaria sinensis flowers are not researched for the aquilaria sinensis toothpaste.
Disclosure of Invention
Therefore, the invention aims to provide agilawood toothpaste and a preparation method thereof, and aims to provide the agilawood toothpaste which is suitable for smokers and is allergy-free and dental caries-preventing. The technical scheme of the invention is realized as follows:
an agilawood toothpaste comprises, by weight, 10-60 parts of an abrasive, 30-50 parts of a humectant, 0.5-2 parts of a thickener, 1-3 parts of a foaming agent, 0.1-5 parts of a functional agent and 0.2-3 parts of water, wherein the functional agent comprises an agilawood extract and an anti-allergic agent, and the agilawood extract is one or two of an agilawood leaf extract and an agilawood flower extract which are mixed in any proportion; the antiallergic agent comprises baking soda, amelogenin extract and calcium phosphate.
The ethanol extracts of the agilawood leaves and the agilawood flowers are rich in flavonoid compounds, and the agilawood leaf and agilawood flavonoid extracts have strong capacity of eliminating DPPH free radicals and ABTS +, so that the agilawood extracts have good antioxidation.
The baking soda enhances the cleaning effect on teeth, and helps to achieve the effects of preventing dental caries, refreshing breath and inhibiting harmful bacteria in oral cavity by neutralizing the pH value of the oral cavity and maintaining the good pH value environment of the oral cavity. Tooth sensitivity is mainly caused by the destruction of enamel on the surface of teeth, which causes soreness when the teeth are subjected to external stimuli such as cold, heat, acid, sweet food and hard food. The baking soda, the amelogenin extract and the calcium phosphate jointly form an anti-allergic raw material, after the baking soda, the amelogenin extract and the calcium phosphate meet water or saliva in an oral cavity, a similar enamel structure layer is generated on the surface of teeth, and then the teeth with damaged enamel are repaired, so that the tooth allergy is prevented or relieved, and meanwhile, the anti-allergic raw material timely repairs the teeth without the enamel, so that the generation of dental caries is also prevented.
The further technical scheme is that the weight ratio of the agilawood extract to the antiallergic agent is 1: 0.1-3.
The further technical scheme is that the weight ratio of the raw materials of the antiallergic agent is as follows: 0.5-2 parts of baking soda, 1-3 parts of amelogenin extract and 20-30 parts of calcium phosphate.
The further technical scheme is that agilawood extract is replaced by agilawood powder, and the agilawood powder is one or two of agilawood leaf powder and agilawood pollen mixed in any proportion.
The further technical proposal is that the abrasive is silicon dioxide; the foaming agent raw material is one or more of N-lauroyl-L-alanine or salts thereof which are mixed in any proportion; the humectant is prepared by mixing one or more of sorbitol, polyethylene glycol, glycerol and propylene glycol in any proportion; the raw materials of the thickening agent are one or more of sodium carboxymethyl cellulose, silica powder, carbomer, xanthan gum and carrageenan which are mixed in any proportion.
The preparation method of the agilawood toothpaste sequentially comprises the following steps:
(1) preparation of functional agent raw materials: comprises the preparation of agilawood powder, the preparation of agilawood extract and the preparation of amelogenin extract;
(2) firstly, stirring and mixing a friction agent and a thickening agent, then adding a humectant, stirring and mixing, then adding water, stirring and mixing, and finally standing for 6-12h for aging to prepare a colloid;
(3) adding a functional agent into the colloid, stirring and standing for 2-3h for aging to prepare a functional agent colloid;
(4) and finally, adding the foaming agent into the functional agent colloid, continuously stirring and standing for 3-5h for aging, and then carrying out vacuum degassing to prepare the agilawood toothpaste.
The reason for stirring and mixing the abrasive and the thickening agent is that the abrasive accounts for the largest weight ratio in the toothpaste, is insoluble in water and is easier to disperse the thickening agent uniformly; adding a humectant and water for aging to enable the uniformly dispersed thickener to form a colloid with a net structure, adding a functional agent into the colloid for stirring to enable the functional agent to be uniformly adsorbed on the colloid with the net structure, and finally adding a foaming agent to enable the foaming agent to cover the net colloid which is adsorbed with the functional agent.
The further technical scheme is that the agilawood powder is prepared by the following steps: drying eaglewood leaves or eaglewood flowers at 40-50 ℃ for 2-3h in sequence, crushing the eaglewood leaves or the eaglewood flowers, and sieving the crushed eaglewood leaves or the eaglewood flowers with a 50-70 mesh sieve to prepare eaglewood powder; the mass ratio of the agilawood powder to the ethanol solution is 1: 15-20.
The further technical scheme is that the preparation of the agilawood extract comprises the following steps: adding 70-80% ethanol solution into the lignum Aquilariae Resinatum powder, extracting at 50-60 deg.C for 3-5 hr, decolorizing, removing impurities, concentrating, and drying to obtain lignum Aquilariae Resinatum extract.
The further technical scheme is that the preparation of the amelogenin extract comprises the following steps: taking an animal dental germ, removing soft tissues on the surface of the dental germ, cleaning the dental germ by using physiological saline (a sodium chloride aqueous solution with the mass concentration of 0.9%), scraping unmineralized enamel matrix on the surface of a dental crown, adding an acetic acid solution into the enamel matrix, stirring for 12-24 hours at 0-4 ℃, and taking supernatant; adding saturated ammonium sulfate solution into the supernatant, stirring until precipitate is not separated out, collecting precipitate, and dialyzing with deionized water to remove salt to obtain amelogenin extract;
the further technical scheme is that the mass concentration of the acetic acid solution is 1-3%, and the mass ratio of the glaze substrate to the acetic acid solution is 1: 20-30.
Compared with the prior art, the invention has the beneficial effects that:
(1) the N-lauroyl-L-alanine or the salt thereof is an amino acid foaming agent, is safe and mild, has good foaming effect, has excellent effects of stain removal, bacteriostasis and tooth health maintenance, and avoids the side effects (low toxicity) of sodium lauryl sulfate, sodium lauroyl sarcosine and the like on teeth.
(2) The anti-allergen material disclosed by the invention can generate a structure layer similar to enamel on the surface of teeth after contacting water or saliva in the oral cavity, so that the teeth with damaged enamel can be repaired, the tooth allergy can be prevented or alleviated, and the tooth lacking enamel can be timely repaired by the anti-allergen material, so that the generation of dental caries can be prevented.
(3) The agilawood toothpaste disclosed by the invention has a good bacteriostatic action on staphylococcus aureus, escherichia coli, candida albicans, porphyromonas gingivalis and klebsiella pneumoniae, particularly has a stronger bacteriostatic action on the porphyromonas gingivalis and klebsiella pneumoniae, and is particularly suitable for smokers because the oral cavity of the smokers contains more porphyromonas gingivalis and klebsiella pneumoniae.
(4) The addition of the eaglewood leaf and flower extract, the eaglewood leaf powder and the eaglewood pollen can keep the stability of the toothpaste.
Detailed Description
For clear and complete description of the technical solutions in the present invention, it is obvious that the inventor combines the embodiments to describe, but the following embodiments describe only some embodiments of the present invention, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The agilawood toothpaste comprises, by weight, 45 parts of an abrasive, 30 parts of a humectant, 1 part of a thickening agent, 2 parts of a foaming agent, 3 parts of a functional agent and 1 part of water, wherein the functional agent is an agilawood flower extract, and the foaming agent is N-lauroyl-L-alanine; the humectant is prepared from glycerol; the raw material of the thickening agent is xanthan gum.
Example 2
The agilawood toothpaste comprises, by weight, 60 parts of an abrasive, 50 parts of a humectant, 2 parts of a thickening agent, 3 parts of a foaming agent, 5 parts of a functional agent and 3 parts of water, wherein the functional agent is prepared by mixing agilawood leaf extract and agilawood flower extract in a ratio of 1: 1.
The foaming agent is prepared from N-lauroyl-L-alanine sodium; the humectant is prepared from sorbitol; the raw material of the thickening agent is sodium carboxymethyl cellulose.
Example 3
The agilawood toothpaste comprises, by weight, 45 parts of an abrasive, 30 parts of a humectant, 1 part of a thickening agent, 2 parts of a foaming agent, 3 parts of a functional agent and 1 part of water, wherein the functional agent is prepared by mixing agilawood leaf powder and agilawood pollen in a ratio of 1: 2.
The foaming agent is prepared from N-lauroyl-L-potassium alanine; the humectant is prepared from glycerol; the raw material of the thickening agent is carrageenan.
Example 4
The agilawood toothpaste comprises, by weight, 45 parts of an abrasive, 30 parts of a humectant, 1 part of a thickening agent, 2 parts of a foaming agent, 3 parts of a functional agent and 1 part of water, wherein the functional agent is prepared from an agilawood flower extract and an anti-allergen material, and the anti-allergen material is baking soda, an enamel protein extract and calcium phosphate. The weight ratio of the agilawood flower extract to the anti-allergen material is 1: 0.1. The weight ratio of the raw materials of the antiallergic agent is as follows: 0.5 part of baking soda, 1 part of amelogenin extract and 20 parts of calcium phosphate.
The foaming agent is prepared from N-lauroyl-L-alanine; the humectant is prepared from glycerol; the raw material of the thickening agent is xanthan gum.
Example 5
The agilawood toothpaste comprises, by weight, 45 parts of an abrasive agent, 30 parts of a humectant, 1 part of a thickening agent, 2 parts of a foaming agent, 3 parts of a functional agent and 1 part of water, wherein the functional agent comprises agilawood pollen and an anti-allergen material, and the anti-allergen material comprises baking soda, an enamel protein extract and calcium phosphate. The weight ratio of the agilawood pollen to the anti-allergen material is 1: 0.1. The weight ratio of the raw materials of the antiallergic agent is as follows: 0.5 part of baking soda, 1 part of amelogenin extract and 20 parts of calcium phosphate.
The foaming agent is prepared from N-lauroyl-L-alanine; the humectant is prepared from glycerol; the raw material of the thickening agent is xanthan gum.
Example 6
The preparation method of the agilawood toothpaste of examples 1-5 sequentially comprises the following steps:
(1) preparation of functional agent raw materials: comprises the preparation of agilawood powder, the preparation of agilawood extract and the preparation of amelogenin extract;
(2) firstly, stirring and mixing a friction agent and a thickening agent, then adding a humectant, stirring and mixing, then adding water, stirring and mixing, and finally standing for 6 hours for aging to prepare a colloid;
(3) adding a functional agent into the colloid, stirring and standing for 2h for aging to prepare a functional agent colloid;
(4) and finally, adding a foaming agent into the functional agent colloid, continuously stirring and standing for 3h for aging, and then carrying out vacuum degassing to prepare the agilawood toothpaste.
The agilawood powder is prepared by the following steps: drying eaglewood leaves or agilawood flowers at 40 ℃ for 2h in sequence, crushing and screening by a 50-mesh screen to prepare eaglewood powder; the mass ratio of the agilawood powder to the ethanol solution is 1: 15.
The preparation of the agilawood extract comprises the following steps: adding 80% ethanol solution into the lignum Aquilariae Resinatum powder, extracting at 60 deg.C for 5 hr, decolorizing, removing impurities, concentrating, and drying to obtain lignum Aquilariae Resinatum extract.
The preparation method of the amelogenin extract comprises the following steps: taking an animal dental germ, removing soft tissues on the surface of the dental germ, cleaning the dental germ by using physiological saline (a sodium chloride aqueous solution with the mass concentration of 0.9%), scraping unmineralized enamel matrix on the surface of a dental crown, adding an acetic acid solution into the enamel matrix, stirring for 12 hours at 0 ℃, and taking supernatant; adding saturated ammonium sulfate solution into the supernatant, stirring until precipitate is not separated out, collecting precipitate, and dialyzing with deionized water to remove salt to obtain amelogenin extract;
the mass concentration of the acetic acid solution is 1%, and the mass ratio of the glaze substrate to the acetic acid solution is 1: 20.
Comparative example 1
Compared with example 5, the antiallergic material is a composition of baking soda and calcium phosphate. The weight ratio of the raw materials of the antiallergic agent is as follows: 0.5 part of baking soda and 20 parts of calcium phosphate. The rest is the same as in example 5.
Comparative example 2
Compared with the embodiment 5, the preparation method of the agilawood toothpaste sequentially comprises the following steps of:
(1) preparation of functional agent raw materials: comprises the preparation of agilawood pollen and the preparation of amelogenin extract;
(2) firstly, stirring and mixing the humectant and the thickener, then adding water, stirring and mixing, and finally standing for 6 hours for aging to prepare colloid;
(3) adding a functional agent into the colloid, stirring and standing for 2h for aging to prepare a functional agent colloid;
(4) and finally, adding a friction agent and a foaming agent into the functional agent colloid, continuously stirring and standing for 3 hours for aging, and then carrying out vacuum degassing to prepare the agilawood toothpaste. The rest is the same as in example 5.
Comparative example 3
Compared with the embodiment 5, the preparation method of the agilawood toothpaste sequentially comprises the following steps of:
(1) preparation of functional agent raw materials: comprises the preparation of agilawood pollen and the preparation of amelogenin extract;
(2) firstly, stirring and mixing the humectant, the thickener, the water, the friction agent, the foaming agent and the functional agent, and then standing for 6 hours for aging to prepare colloid; vacuum degassing to obtain lignum Aquilariae Resinatum toothpaste. The rest is the same as in example 5.
Comparative example 4
Compared with the example 5, the functional agent raw material does not contain agilawood pollen, and the rest is the same as the example 5.
Toothpaste bacteriostasis test
Taking a clean pollution-free filter paper sheet, beating the filter paper sheet into a filter paper sheet with the diameter of 4mm by using a puncher, loading the filter paper sheet into a test tube, carrying out autoclave at 121 ℃ for 15min, taking out the filter paper sheet, and placing the filter paper sheet in a drying box at 80 ℃ for drying; then, 50mg of toothpaste was added to each filter paper sheet, and the mixture was naturally dried in a constant temperature oven (37 ℃) for 5min for use.
Uniformly smearing and inoculating activated staphylococcus aureus, escherichia coli, candida albicans, porphyromonas gingivalis and klebsiella pneumoniae on a nutrient agar culture dish plate, and then pasting toothpaste filter paper sheets of different test groups on the inoculated nutrient agar culture dish plate, wherein the distance between the centers of the toothpaste filter paper sheets is not less than 20mm, and the distance between the centers of the toothpaste filter paper sheets and the periphery of the culture medium plate is not less than 15 mm. The culture medium is divided into two groups, one group is as follows: each medium was separately applied with 1 negative control of distilled water, 5 filter paper sheets of the toothpastes of examples 1-5; the two groups are: each culture medium was separately pasted with 1 negative control of distilled water, 5 filter paper sheets of the toothpastes of example 5 and comparative examples 1-4; three replicates per set. The culture plate is covered and placed in a constant temperature incubator at 37 ℃, and the result can be observed after the culture is carried out for 24 hours. And (3) placing the nutrient agar culture dish inoculated with the porphyromonas gingivalis in an anaerobic bag at 37 ℃ to grow and observe the result. The size of the zone of inhibition was measured to include the diameter and size of the negative patch. See table 1.
TABLE 1
As can be seen from Table 1, examples 1-5 have better bacteriostatic effects on Staphylococcus aureus, Escherichia coli, Candida albicans, Porphyromonas gingivalis and Klebsiella pneumoniae than the distilled water control group, especially have stronger bacteriostatic effects on Porphyromonas gingivalis and Klebsiella pneumoniae, and the size of the bacteriostatic ring is 12.9-16.3 mm. Therefore, the agilawood toothpaste has antibacterial property on common oral bacteria and fungi, and also has strong antibacterial property on porphyromonas gingivalis and klebsiella pneumoniae contained in the oral cavity of smokers. In addition, the antibacterial activity of the agilawood toothpaste prepared in examples 4-5 on porphyromonas gingivalis and klebsiella pneumoniae is obviously superior to that of examples 1-3, which shows that after the anti-allergen material is added, the antibacterial activity of the agilawood toothpaste on porphyromonas gingivalis and klebsiella pneumoniae is enhanced; the antibacterial activity of the anti-allergen material in the comparative example 1 to porphyromonas gingivalis and klebsiella pneumoniae is not much different from that in the example 5 because the amelogenin extract is not added, which indicates that the amelogenin extract in the anti-allergen material plays a main role in the antibacterial activity to porphyromonas gingivalis and klebsiella pneumoniae.
As can be seen from comparison between example 5 and comparative examples 2-3, the antibacterial activity of the agilawood toothpaste is affected due to different addition sequences of the components in the preparation of the agilawood toothpaste, specifically, in comparative example 2, the humectant and the thickener are mixed, except for glycerin which is insoluble in water, the other humectants cannot well disperse the thickener uniformly, so that the adsorption of the functional thickener on the functional agent is directly affected, and the antibacterial activity of the toothpaste is further affected; mixing all ingredients of the toothpaste together in comparative example 3 also affected the better formation of the network structure colloid by the thickener and the uniform adsorption of other ingredients on the colloid. The silicon dioxide used as the abrasive in example 5 is insoluble in water, and is firstly mixed with the thickening agent, the thickening agent is uniformly dispersed, and finally the foaming agent is added to enable the silicon dioxide to be adsorbed on the surface of the toothpaste more, so that the foaming effect is improved.
It can be seen from example 5 and comparative example 4 that, the toothpaste has a certain bacteriostatic action only on escherichia coli and candida albicans without adding the agilawood pollen, and therefore, the agilawood pollen in the toothpaste mainly has a bacteriostatic action on staphylococcus aureus, escherichia coli, candida albicans, porphyromonas gingivalis and klebsiella pneumoniae, while the comparative example 4 has a certain bacteriostatic action only on escherichia coli and candida albicans and possibly has a bacteriostatic action on the weak alkalinity of sodium bicarbonate in the toothpaste.
Toothpaste stability test
The shelf life of the toothpaste is generally three years, so that the toothpaste is subjected to an accelerated aging test, the condition in the shelf life is simulated, and the stability of the toothpaste is judged.
The prepared toothpaste is stored in a constant temperature oven (the aging of the paste is accelerated by the temperature of 45 ℃) at the temperature of 45 ℃, the toothpaste is taken out at the time of 3 months, the change of appearance, fragrance, p H value and the like is observed, and the stability within the shelf life of 3 years is judged according to the result. Three replicates were run per group.
TABLE 2
As can be seen from Table 2, compared with example 5, comparative example 4 has no agilawood powder, the toothpaste has a fine appearance, is moderate in thickness and fragrance, and has a reduced pH value, so that the agilawood powder directly influences the stability of the toothpaste; while the toothpaste of examples 1-4 and comparative examples 1-3 has normal appearance, stable fragrance and stable pH value, it can be seen that the addition of the eaglewood leaves and the agilawood flower extract or the eaglewood leaves and the agilawood pollen can keep the stability of the toothpaste, and the main reason is that the oxidation resistance of the compounds in the eaglewood leaves and the agilawood flower extract or the eaglewood leaves and the agilawood pollen maintains the stability of the toothpaste body.
In addition, the comparative examples 2-3 have a finer appearance or contain excessively hard particles, compared to example 5, mainly due to the order of addition of the agilawood components in the preparation process of the agilawood toothpaste.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. An agilawood toothpaste is characterized in that: the agilawood toothpaste comprises, by weight, 10-60 parts of an abrasive, 30-50 parts of a humectant, 0.5-2 parts of a thickener, 1-3 parts of a foaming agent, 0.1-5 parts of a functional agent and 0.2-3 parts of water, wherein the functional agent comprises an agilawood extract and an anti-allergic agent, and the agilawood extract is one or two of an agilawood leaf extract and an agilawood flower extract which are mixed in any proportion; the antiallergic agent comprises baking soda, amelogenin extract and calcium phosphate.
2. The agilawood toothpaste according to claim 2, wherein: the weight ratio of the agilawood extract to the antiallergic agent is 1: 0.1-3.
3. The agilawood toothpaste according to claim 2, wherein: the weight ratio of the raw materials of the antiallergic agent is as follows: 0.5-2 parts of baking soda, 1-3 parts of amelogenin extract and 20-30 parts of calcium phosphate.
4. The agilawood toothpaste according to claims 1-3, wherein: replacing the agilawood extract with agilawood powder, wherein the agilawood powder is one or two of agilawood leaf powder and agilawood pollen mixed in any proportion.
5. The agilawood toothpaste according to claim 1, wherein: the abrasive is silicon dioxide; the foaming agent is one or more of N-lauroyl-L-alanine or salts thereof which are mixed in any proportion; the humectant is one or a mixture of more of sorbitol, polyethylene glycol, glycerol and propylene glycol in any proportion; the thickening agent is one or more of sodium carboxymethyl cellulose, silica powder, carbomer, xanthan gum and carrageenan which are mixed in any proportion.
6. A method for preparing the agilawood toothpaste as claimed in any one of claims 1-3 or 5, characterized in that: the method sequentially comprises the following steps:
(1) preparation of functional agent raw materials: comprises the preparation of agilawood powder, the preparation of agilawood extract and the preparation of amelogenin extract;
(2) firstly, stirring and mixing a friction agent and a thickening agent, then adding a humectant, stirring and mixing, then adding water, stirring and mixing, and finally standing for 6-12h for aging to prepare a colloid;
(3) adding a functional agent into the colloid, stirring and standing for 2-3h for aging to prepare a functional agent colloid;
(4) and finally, adding the foaming agent into the functional agent colloid, continuously stirring and standing for 3-5h for aging, and then carrying out vacuum degassing to prepare the agilawood toothpaste.
7. The preparation method of agilawood toothpaste according to claim 6, characterized by comprising the following steps: the agilawood powder is prepared by the following steps: drying Aquilaria sinensis leaf or flos Aquilariae Resinatum at 40-50 deg.C, pulverizing, and sieving with 50-70 mesh sieve to obtain lignum Aquilariae Resinatum powder; the mass ratio of the agilawood powder to the ethanol solution is 1: 15-20.
8. The preparation method of agilawood toothpaste according to claim 7, characterized by comprising the following steps: the preparation of the agilawood extract comprises the following steps: adding 70-80% ethanol solution into the lignum Aquilariae Resinatum powder, extracting at 50-60 deg.C for 3-5 hr, decolorizing, removing impurities, concentrating, and drying to obtain lignum Aquilariae Resinatum extract.
9. The preparation method of agilawood toothpaste according to claim 7, characterized by comprising the following steps: the preparation method of the amelogenin extract comprises the following steps: taking an animal dental germ, removing soft tissues on the surface of the dental germ, cleaning with normal saline, scraping unmineralized enamel matrix on the surface of a dental crown, adding an acetic acid solution into the enamel matrix, stirring at 0-4 ℃ for 12-24h, and taking supernatant; adding saturated ammonium sulfate solution into the supernatant, stirring until precipitate is not separated out, collecting precipitate, and dialyzing with deionized water to remove salt to obtain amelogenin extract.
10. The preparation method of agilawood toothpaste according to claim 7, characterized by comprising the following steps: the mass concentration of the acetic acid solution is 1-3%, and the mass ratio of the glaze substrate to the acetic acid solution is 1: 20-30.
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| CN115844800A (en) * | 2022-12-07 | 2023-03-28 | 海南嘉米拉沉香生物科技有限公司 | Toothpaste capable of refreshing breath |
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