CN102335110B - Powder toothpaste combination comprising Au particles and manufacturing method thereof - Google Patents
Powder toothpaste combination comprising Au particles and manufacturing method thereof Download PDFInfo
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- CN102335110B CN102335110B CN2011101930112A CN201110193011A CN102335110B CN 102335110 B CN102335110 B CN 102335110B CN 2011101930112 A CN2011101930112 A CN 2011101930112A CN 201110193011 A CN201110193011 A CN 201110193011A CN 102335110 B CN102335110 B CN 102335110B
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- 239000000843 powder Substances 0.000 title claims abstract description 207
- 229910052737 gold Inorganic materials 0.000 title claims abstract description 110
- 239000002245 particle Substances 0.000 title claims abstract description 109
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
- 239000000606 toothpaste Substances 0.000 title abstract description 38
- 229940034610 toothpaste Drugs 0.000 title abstract description 38
- 239000000203 mixture Substances 0.000 claims abstract description 150
- 230000001954 sterilising effect Effects 0.000 claims abstract description 45
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 30
- 210000000214 mouth Anatomy 0.000 claims abstract description 23
- 238000001035 drying Methods 0.000 claims abstract description 20
- 238000005282 brightening Methods 0.000 claims abstract description 16
- 239000003086 colorant Substances 0.000 claims abstract description 16
- 239000010931 gold Substances 0.000 claims description 149
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical group [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 108
- 230000000844 anti-bacterial effect Effects 0.000 claims description 51
- 239000000551 dentifrice Substances 0.000 claims description 37
- 239000000084 colloidal system Substances 0.000 claims description 32
- 241000894006 Bacteria Species 0.000 claims description 26
- 241000125175 Angelica Species 0.000 claims description 24
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 24
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 17
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000002671 adjuvant Substances 0.000 claims description 13
- 239000002516 radical scavenger Substances 0.000 claims description 13
- 231100000241 scar Toxicity 0.000 claims description 13
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 12
- 239000008101 lactose Substances 0.000 claims description 12
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 12
- 239000000600 sorbitol Substances 0.000 claims description 12
- 241000241413 Propolis Species 0.000 claims description 11
- 229940069949 propolis Drugs 0.000 claims description 11
- HSQFVBWFPBKHEB-UHFFFAOYSA-N 2,3,4-trichlorophenol Chemical compound OC1=CC=C(Cl)C(Cl)=C1Cl HSQFVBWFPBKHEB-UHFFFAOYSA-N 0.000 claims description 10
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 9
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 9
- 239000000811 xylitol Substances 0.000 claims description 9
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 9
- 229960002675 xylitol Drugs 0.000 claims description 9
- 235000010447 xylitol Nutrition 0.000 claims description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 8
- 241000717739 Boswellia sacra Species 0.000 claims description 8
- 239000004863 Frankincense Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 229940085605 saccharin sodium Drugs 0.000 claims description 8
- 238000005868 electrolysis reaction Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000000377 silicon dioxide Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 6
- 239000011775 sodium fluoride Substances 0.000 claims description 6
- 235000013024 sodium fluoride Nutrition 0.000 claims description 6
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 31
- 208000002064 Dental Plaque Diseases 0.000 abstract description 13
- 206010006326 Breath odour Diseases 0.000 abstract description 12
- 208000024693 gingival disease Diseases 0.000 abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 7
- 230000002708 enhancing effect Effects 0.000 abstract description 5
- 239000004615 ingredient Substances 0.000 abstract description 3
- 208000010641 Tooth disease Diseases 0.000 abstract description 2
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 235000019605 sweet taste sensations Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 33
- 240000002900 Arthrospira platensis Species 0.000 description 12
- 235000016425 Arthrospira platensis Nutrition 0.000 description 12
- 229940082787 spirulina Drugs 0.000 description 12
- 208000032139 Halitosis Diseases 0.000 description 11
- 208000002925 dental caries Diseases 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 9
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 9
- 230000002265 prevention Effects 0.000 description 9
- 239000012153 distilled water Substances 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 230000009931 harmful effect Effects 0.000 description 5
- 239000002054 inoculum Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 238000003113 dilution method Methods 0.000 description 3
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium oxide Inorganic materials O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- PVADDRMAFCOOPC-UHFFFAOYSA-N oxogermanium Chemical compound [Ge]=O PVADDRMAFCOOPC-UHFFFAOYSA-N 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 241000219317 Amaranthaceae Species 0.000 description 2
- 241000190885 Capnocytophaga ochracea Species 0.000 description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000605986 Fusobacterium nucleatum Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000013535 sea water Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- -1 stir on one side Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000606750 Actinobacillus Species 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000192700 Cyanobacteria Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000018035 Dental disease Diseases 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000014151 Stomatognathic disease Diseases 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 229910001573 adamantine Inorganic materials 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000011425 bamboo Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000001013 cariogenic effect Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000007602 hot air drying Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 238000009288 screen filtration Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000037204 skin physiology Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960004747 ubidecarenone Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/60—Sugars, e.g. mono-, di-, tri-, tetra-saccharides
- A23V2250/64—Sugar alcohols
- A23V2250/6422—Xylitol
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a powder toothpaste combination comprising Au particles and a manufacturing method thereof, and in more detail, provides a powder toothpaste combination comprising Au particles and a manufacturing method thereof advantaged by taking effect of sterilization via use of inherent property of a Au ingredient having no side effect in the oral cavity, and taking effect of sterilization in short time, thereby taking effect of substantial sterilization as powder toothpaste for use, preventing decayed teeth and gum disease, and improving effect of eliminating bad breath. The powder toothpaste combination comprising Au particles is formed via the following method: ingredients of Au particles, a tooth plaque removing agent, a sterilization capability enhancing auxiliary agent, a sweet taste agent, a form-giving agent, a flavouring agent, a brightening agent, and a coloring agent are thrown into a mixer to form a powder mixture, the powder mixture is stirred and mixed while a Au particle colloidal solution is uniformly injected so as to perform coating and drying, and the powder toothpaste combination is formed.
Description
Technical field
The present invention relates to contain powder dentifrice composition and the manufacture method thereof of gold particle, relate in more detail utilize gold (Au) thus the intrinsic character of composition plays bactericidal action with being free from side effects, and can play at short notice bactericidal action and be suitable for the powder dentifrice composition and the manufacture method thereof that contain gold particle that also can play substantial bactericidal action, caries prevention and gingival disease and can improve removing halitosis effect as powder toothpaste in the oral cavity.
Background technology
Generally, for the cleaning of oral cavity and tooth and the toothpaste that uses is widely used paste toothpaste, but use for a long time or the lid of opening pipe through certain hour, then the fore-end of pipe solidify and be not easy to extrude or out of use situation more.In addition, in use, the inner residual toothpaste of pipe can not be finished fully, inject the pipe of toothpaste as disposable pipe, can only throw away at every turn, so waste is serious, have the problem of environmental pollution.
In order to solve such problem, can use more meticulously toothpaste, and propose to reuse the liquid toothpaste of container.But such liquid toothpaste is when it uses, and has the problem that the liquid toothpaste compositions flows out easily and use is very inconvenient, waste is serious, so do not use in reality.
On the other hand, the scheme as for the problem that solves above-mentioned paste toothpaste and liquid toothpaste has proposed powder toothpaste recently.As such powder toothpaste, shown in " dentifrice composition that contains the germanium oxide powder " of Korean granted patent communique patent No. 10-0614685 number, propose to contain purity and be the germanium oxide powder more than 99%, thereby can improve the dentifrice composition of the descale effect of the dental calculus that utilizes the distinctive porous space of germanium oxide to remove dental surface.
And, shown in " the powder Chinese prescription toothpaste " of Korea S's publication communique publication number 10-2006-0102681 number, propose powder salt, bamboo salt, Pulvis Talci, Maifanitum, Chinese drugs powder brought into play the effect of removing dental plaque or protection oral cavity, and can protect adamantine powder toothpaste; " containing the powder toothpaste as the Maifanitum in far infrared irradiation source " that Korea S's publication communique publication number is 10-2006-0008509 number proposed to have brought into play from the powder toothpaste of effective effect of the far infrared of Maifanitum radiation.
In addition, shown in " manufacture method of the powder toothpaste of prevention and treatment periodontitis, dental caries, apicitis etc. " of special 1997-0069019 number of Korea S publication communique publication number, propose the salt-mixture powder, fried Semen Gleditsiae powder, Colophonium powder etc., the powder toothpaste of prevention and treatment tooth or gum disease, particularly periodontitis, dental caries, apicitis etc.
Yet, although removing the aspects such as effect and gum disease at descale effect, dental plaque, above-mentioned powder toothpaste in the past can bring into play separately certain effect, but because a little less than the sterilizing ability, can not expect sufficient effect so remove the removing of dental plaque in oral cavity and oral cavity bacterium.
For this reason, need to drop into the chemical additive that plays bactericidal action, therefore occured to cause stimulating the skin in responsive oral cavity or bringing dysgenic problem.For example, in toothpaste for bactericidal action widely used fluoride preparation, although can effectively play the dental caries of prophylaxis of teeth or the function of anti-bacteria, but relatively can not bring into play good bactericidal effect for the gingiva of supports tooth or the skin of inside, oral cavity, and existence brings unhappy problem owing to making tooth generation speckle or medicine taste to consumer.
In order to address the above problem, the applicant has proposed 2007-0048135 number disclosed powder dentifrice composition that contains gold particle of korean patent application.
The powder dentifrice composition that contains gold particle that korean patent application proposes for 2007-0048135 number contains gold particle 0.0005～1 % by weight, hexadecylpyridinium chloride
Powder 0.1～5 % by weight, ubidecarenone (coenzyme Q10) powder 0.0001～2 % by weight, propolis extract powder 0.1～5 % by weight, hydroxyapatite powder 0.5～2 % by weight, sorbitol powder 2.0～30 % by weight and as excipient, be selected from silicon dioxide, moisture silicic acid, lactose, the titanium oxide more than one excipient powders 10～80 % by weight and consist of.
The powder dentifrice composition that contains gold particle like this utilizes the intrinsic bactericidal action of golden composition and strengthens at intraoral sterilizing ability, thereby has played the effect of caries prevention and gum disease.And, be dissolved in sterile purified water with identical amount above-mentioned powder dentifrice composition after, pour in the test strain, after 1 minute time, measure remaining bacterium number, the result is determined as has excellent sterilizing ability and antibacterial ability.
But, above-mentioned sterilization and antibacterial ability test are the sterilizing abilities of in advance the powder dentifrice composition being measured after the long time is dissolved in solvent (sterile purified water), therefore as can be known owing to there not be consideration to contain characteristic in the use of powder dentifrice composition of gold particle, so compare the difference with suitable sterilizing ability when in fact using as the purposes of toothpaste.Namely, the powder dentifrice composition that will contain gold particle be not dissolved in advance solvent state under, carry out bactericidal assay according to identical method, as a result sterilization is compared remarkable reduction with antibacterial ability with the situation of having carried out in advance dissolving, therefore can not expect sufficient bactericidal effect when gargling.
Studied its reason, the powder dentifrice composition that the result contains particle is the toothpaste of powder morphology, so different from paste toothpaste or liquid toothpaste when gargling, the time that the material of needs performance sterilizing ability dissolves, but gargle owing to probably in 3 minutes, finishing, so can not bring into play sufficient sterilizing ability.The gold particle that particularly contains as the main component of bringing into play sterilizing ability is owing to be the natural materials of being free from side effects, have the skin that does not stimulate responsive oral cavity or bring harmful effect, to have got rid of the chemical substance of adding in addition in order sterilizing and not produce the advantage of medicine taste, but be not allow diffluent solid granulates, have certain limit in bactericidal action, therefore need to replenish it.
Summary of the invention
The present invention is conceived to solve above-mentioned problem in the past, purpose is to provide utilizes the intrinsic character of gold (Au) composition to play bactericidal action with being free from side effects in the oral cavity, and can play bactericidal action at short notice, thereby even be suitable for the powder dentifrice composition that contains gold particle that also can play substantial bactericidal action, caries prevention and gingival disease and can improve removing halitosis effect as powder toothpaste.
Be characterised in that for the powder dentifrice composition that contains gold particle that reaches aforesaid purpose of the present invention, form by the following method the powder dentifrice composition that contains gold particle: will be by gold particle, scavenger for dental scar, sterilizing ability strengthens adjuvant, sweeting agent, excipient, fumet, above-mentioned each composition that brightening agent and coloring agent form is put into mixer and is formed mixture of powders, stir on one side, gold (Au) the particle,colloid solution that mixes concentration that above-mentioned mixture of powders sprays gold (Au) particle on one side equably and be 25～55ppm is coated with, and carries out drying and form; With respect to the weight of above-mentioned mixture of powders, above-mentioned gold (Au) particle,colloid solution is 3～10 % by weight; Gold particle is as the antibacterial of anti-bacteria in the oral cavity, and its particle diameter is 10～200 mu m ranges, and contains with 0.0005～1.0 % by weight scope; Scavenger for dental scar contains and is selected from hexadecylpyridinium chloride
0.1 in～0.5 % by weight, sodium fluoride 0.01～0.05 % by weight, sodium monofluorophosphate 0.1～0.7 % by weight a kind or 2 kinds; Sterilizing ability strengthen adjuvant contain be selected from trichlorophenol 0.01～0.5 % by weight, Olibanum oil 0.01～0.5 % by weight, propolis extract powder 0.1～5 % by weight more than a kind; Sweeting agent contain be selected from xylitol powder 1.0～10 % by weight, saccharin sodium 0.01～1.0 % by weight, sorbitol powder 2.0～30 % by weight more than a kind; Excipient contain be selected from lactose 50.0～86.0 % by weight, silica 1 9.0～75.0 % by weight more than a kind; The surplus % by weight of stating each composition more than fumet, brightening agent, coloring agent form contains.
And, above-mentioned fumet contain be selected from minty note powder 1.0～5 % by weight, Herba Menthae Rotundifoliae powder 1.0～5.0 % by weight more than a kind, above-mentioned brightening agent contains the hydroxyapatite of 0.5～2 % by weight scope, and above-mentioned coloring agent contains the spirulina blue color of 0.001～1.0 % by weight scope.
On the other hand, above-mentioned gold (Au) particle,colloid solution is characterised in that the process by 99.9% gold medal of electrolysis in distilled water (Au) rod, carry out ionizing, thus in distilled water, contain 0.001～0.015 micron about (μ m) gold (Au) fundamental particle and form.
And, be coated with above-mentioned gold (Au) particle,colloid solution and drying after, can also contain the angelica powder, with respect to the total weight of above-mentioned mixture of powders, above-mentioned angelica powder is 1～10 % by weight scope.
Manufacture method for the powder dentifrice composition that contains gold particle that reaches aforesaid purpose of the present invention, possess: powder composition preparation process, namely, prepare respectively as the antibacterial that suppresses oral cavity bacterium, particle diameter is 10～200 mu m ranges and the gold particle that contains with 0.0005～1.0 % by weight scope, contain to be selected from hexadecylpyridinium chloride
0.1～0.5 % by weight, sodium fluoride 0.01～0.05 % by weight, 1 kind or 2 kinds scavenger for dental scar in sodium monofluorophosphate 0.1～0.7 % by weight, contain and be selected from trichlorophenol 0.01～0.5 % by weight, Olibanum oil 0.01～0.5 % by weight, the sterilizing ability more than a kind in propolis extract powder 0.1～5 % by weight strengthens adjuvant, contain and be selected from xylitol powder 1.0～10 % by weight, saccharin sodium 0.01～1.0 % by weight, the sweeting agent more than a kind in sorbitol powder 2.0～30 % by weight, contain and be selected from lactose 50.0～86.0 % by weight, the excipient more than a kind in silica 1 9.0～75.0 % by weight, and the fumet that contains with the surplus % by weight of above-mentioned each composition, brightening agent, coloring agent.
And, the manufacture method that contains the powder dentifrice composition of gold particle also comprises: the solution preparation process, in electrolysis bath, inject sterile purified water, purity is set is 99.9% gold (Au) rod, coming the concentration of Reserve Fund (Au) particle by electrolytic process is gold (Au) the particle,colloid solution of 25～55ppm; Mixture forms step, forms mixture of powders on one side make above-mentioned each powder composition of preparing in the above-mentioned powder preparation process drop into mixer by 20～30 purpose sieves on one side; Application step, spray above-mentioned gold (Au) particle,colloid solution while stirring, mix described mixture of powders, so that with respect to the weight of above-mentioned mixture of powders, above-mentioned gold (Au) particle,colloid solution is 3～10 % by weight scopes, thereby is coated with on the surface of above-mentioned each powder composition; And drying steps, the mixture of powders that has been coated with above-mentioned gold (Au) particle,colloid solution in the above-mentioned application step is carried out drying.
And, implement above-mentioned drying steps after, also comprise the angelica powders mixing, described angelica powders mixing comprises: drop into the angelica powder, so that with respect to all weight of above-mentioned mixture of powders, above-mentioned angelica powder is 1～10 % by weight scope, and evenly mix.
Utilization is strengthened intraoral sterilizing ability according to the above-mentioned powder dentifrice composition that contains gold particle of the present invention by the intrinsic bactericidal action of golden composition, can improve the preventive effect of dental caries and gum disease, and owing to has added hexadecylpyridinium chloride
, so sterilizing ability and removing halitosis effect further improve.
Particularly, the powder dentifrice composition of gold particle that contains according to the present invention is with the bactericidal action excellence, after the mode that the preventive effect of dental caries and gum disease improves makes up mixture of powders, be scope about 25～55ppm with the concentration of gold (Au) particle, the size of particle is that 0.001～0.015 micron gold (Au) particle,colloid solution coat about (μ m) is in each powder composition and carry out drying, so that can carry out bactericidal action at short notice, thereby be suitable for the effect that also can play substantial bactericidal action even have as powder toothpaste.
The specific embodiment
Below, utilize the manufacturing technology of powder toothpaste to describe in detail according to the powder dentifrice composition that contains gold particle of the present invention, utilize for those skilled in the art structure that prior art in the past learns easily and the detailed description of effect and effect thereof to carry out simple declaration or omission, will describe centered by the part related to the present invention.
The powder dentifrice composition that contains gold particle according to the present invention is will strengthen all the components that adjuvant, sweeting agent, excipient, fumet, brightening agent and coloring agent consist of by the gold particle that contain as the antibacterial that suppresses oral cavity bacterium, scavenger for dental scar, sterilizing ability to drop in the mixer and form mixture of powders, be that gold (Au) the particle,colloid solution of 25～55ppm is coated with while the concentration that stirs, mixes this mixture of powders and spray equably gold (Au) particle, and carry out drying and form; With respect to the weight of mixture of powders, above-mentioned gold (Au) particle,colloid solution is 3～10 % by weight.
Below, each composition that forms mixture of powders is specifically studied.
The character that above-mentioned gold particle becomes branch to have owing to gold (Au) makes at intraoral sterilizing ability and strengthens, anti-bacteria propagation, play the effect of removing dental plaque and prevention disease in mouth, the bactericidal action of such gold particle is the metabolism such as the breathing that acts on antibacterial of gold ion that Aurum metallicum discharges, digestion and play bactericidal action.
And, above-mentioned gold particle is owing to the character that gold (Au) becomes branch to have is strengthened intraoral sterilizing ability, thereby play the effect of caries prevention and gingival disease, as extensive known, gold particle is penetrated in the skin or cell of human body easily, play Antifungi, the effect of the catalyst of the function of needed enzyme when antibacterial or virus etc. are carried out oxygen metabolism, kill at short notice above-mentioned pathogen etc., therefore play the function of the natural bactericidal agent of being free from side effects, in addition, activation skin physiology function and cell regeneration function, play recovery and the Detoxication of the gingival cell of damage, out cation makes the secretion of hormone smooth and easy from gold, plays the effect of keeping intraoral skin health.
Preferably, gold particle is that adding purity is the native gold that 99.9% Aurum metallicum (Au) forms particle diameter 10～200 μ m.
In addition, the content of gold particle is 0.0005～1 % by weight with respect to the total weight of above-mentioned mixture of powders preferably, this reason can be learnt by experiment: if be that then sterilizing ability significantly weakens below 0.0005 % by weight, thereby can not bring into play the preventive effect of removing dental plaque and disease in mouth; If when its weight surpassed 1 % by weight, even appended its content, bactericidal effect can further not increase yet.
Scavenger for dental scar can be suitable for hexadecylpyridinium chloride
(CPC), the inhibition oral cavity bacterium of sodium fluoride, sodium monofluorophosphate and so on and remove dental plaque, and performance disease in mouth prevention and remove the composition of the effect of halitosis.Its content preferably contains hexadecylpyridinium chloride with respect to the total weight of above-mentioned mixture of powders
(CPC) one kind or two or more in 0.1～0.5 % by weight, sodium fluoride 0.01～0.05 % by weight, sodium monofluorophosphate 0.1～0.7 % by weight.
Sterilizing ability strengthens the natural antibiotics that adjuvant can be suitable for trichlorophenol, Olibanum oil, propolis extract and so on.At this moment, preferred mixed phase is for the overall weight of above-mentioned mixture of powders, in trichlorophenol 0.01～0.5 % by weight, Olibanum oil 0.01～0.5 % by weight, propolis extract powder 0.1～5 % by weight more than a kind.
Sweeting agent is to select from can xylitol, saccharin sodium and the sorbitol powder of caries prevention and contain, preferably contain in xylitol powder 1.0～10 % by weight, saccharin sodium 0.01～1.0 % by weight, sorbitol powder 2.0～30 % by weight more than a kind.
Excipient is the material that adds in order to form powder toothpaste with certain form, preferably contain in lactose 50.0～86.0 % by weight, silica 1 9.0～75.0 % by weight more than a kind.
Fumet is to select a kind and contain from minty note powder 1.0～5 % by weight, Herba Menthae Rotundifoliae powder 1.0～5.0 % by weight.
The applicable hydroxyapatite (Hydroxyapatite) that consists of the main constituent of human skeleton and tooth enamel of brightening agent, play the fine damaged part of filling tooth, so that the smooth and glossiness effect of tooth, the scope of its content is 0.5～2 % by weight scope.
The extraction that coloring agent contains 0.001～1.0 % by weight scope is from the spirulina blue color of spirulina (spirulina) and consist of.Spirulina is dark green blue algae, the a kind of of cyanobacteria, it is the spiral type prokaryotic micro-organisms that does not have the spring-like of cell wall, contain a large amount of vitamin, so sulfonation is excellent, improve the resistance that oral cavity bacterium is infected, thereby raising immunity, prevent intraoral gum disease, have powerful bactericidal action as chlorophyllous CHLOROPHYLLINE, so be the material that suppresses oral cavity bacterium propagation.
Above-mentioned gold (Au) particle,colloid solution is to form by the following method, namely, in distilled water, by the electrolytic process ionizing, make distilled water contain 0.001～0.015 micron gold (Au) fundamental particle about (μ m) 99.9% gold medal (Au) rod.
On the other hand, the powder dentifrice composition that contains gold particle according to the present invention can also contain the angelica powder.With regard to the angelica powder, when containing less than 1 % by weight, limited in the utilization of effective ingredient; Be 10 % by weight when above, impair as the frankness sense of toothpaste or use sense that therefore with respect to the total weight of mixture of powders, the angelica powder is 1～10 % by weight scope.
Angelica the sea water in the seashore of Korea S or area, island in one's power seashore or mud bank, salt pan around in flakes growth, owing to be the grass that plump and every joint is all given prominence to, so be also referred to as " fat joint ", 1 year this plant of SHENGCAO that belongs to Chenopodiaceae (chenopodiaceae) at botany classification, as land plant, contain abundant, be dissolved in the various mineral such as the calcium take salt as representative in the sea water, enzyme, potassium, ferrum, phosphorus, thereby to tooth or effectively effect of gingiva performance.
And, the angelica powder can utilize the heating extraction mode extract and powdered after drop into, but in the present embodiment, in order not destroy the effective crude drug composition that contains in the angelica, the angelica of collecting is cleaned, carry out lyophilization, fragmentation drops into the angelica of powdered.
Particularly in order not destroy the effective crude drug composition that contains in the angelica, importantly as described below, behind drying steps, drop in addition, it is not exposed in the steam.
And each the powder composition that forms mixture of powders preferably can pass through the granularity of the degree of 20～50 purpose sieves (drainage screen).
Below, the manufacture method according to the powder dentifrice composition that contains gold particle of preferred implementation of the present invention is described.
The manufacture method that contains the powder dentifrice composition of gold particle according to the present invention is carried out following steps successively: the Reserve Fund particle, scavenger for dental scar, sterilizing ability strengthens adjuvant, sweeting agent, excipient and the fumet that contains with the surplus % by weight of above-mentioned each powder composition, brightening agent, the powder composition preparation process of coloring agent, the solution preparation process of Reserve Fund (Au) particle,colloid solution, the mixture that forms mixture of powders forms step, at the application step of the surface coated of powder composition gold (Au) particle,colloid solution, the drying steps of dry powder mixture.
At first, in powder composition preparation process, prepare respectively as mentioned above: as the antibacterial that suppresses oral cavity bacterium, with the gold particle that 0.0005～1.0 % by weight scope contains, contain and be selected from hexadecylpyridinium chloride
0.1～0.5 % by weight, sodium fluoride 0.01～0.05 % by weight, 1 kind or 2 kinds scavenger for dental scar in sodium monofluorophosphate 0.1～0.7 % by weight, contain and be selected from trichlorophenol 0.01～0.5 % by weight, Olibanum oil 0.01～0.5 % by weight, the sterilizing ability more than a kind in propolis extract powder 0.1～5 % by weight strengthens adjuvant, contain and be selected from xylitol powder 1.0～10 % by weight, saccharin sodium 0.01～1.0 % by weight, the sweeting agent more than a kind in sorbitol powder 2.0～30 % by weight, contain and be selected from lactose 50.0～86.0 % by weight, the excipient more than a kind in silica 1 9.0～75.0 % by weight, and the fumet that contains with the surplus % by weight of described each composition, brightening agent, coloring agent.
The solution preparation process is to inject sterile purified water in electrolysis bath, purity be set be 99.9% gold (Au) rod, coming the concentration of Reserve Fund (Au) particle by electrolytic process is the step of gold (Au) the particle,colloid solution of 25～55ppm, be that 99.9% gold (Au) rod is arranged on electrolysis bath and implements electrolysis as can be known with purity, after the golden composition ionizing of gold (Au) rod, particlized and being present in the distilled water.At this moment, the ionization tendency of Jin Biyin (Ag) is fast, and when its concentration was roughly the 25ppm left and right sides, then particlized and being present in the distilled water began to form colloid solution, and when surpassing 55ppm, then gold particle precipitation not only, and particle mutually combines, and its size increases.
And, in the present embodiment, if electrolysis is scope about 25～55ppm to the concentration of gold (Au) particle, the size of the gold particle that then contains in the sterile purified water is about 0.001～0.015 micron (μ m), by using the little fundamental particle of such particle diameter, when gargling, can more promptly play bactericidal action.
It is to make each powder composition of preparing in the above-mentioned powder composition preparation process put into the step that forms mixture of powders in the mixer on one side by sieve on one side that mixture forms step, at first, with scavenger for dental scar, sterilizing ability strengthen adjuvant, sweeting agent and excipient about with 30 orders the drainage screen filtration and drop into, mix, for the second time a kind in minty note powder, the Herba Menthae Rotundifoliae powder and spirulina blue color are filtered with 30 mesh sieves and behind the input mixer, mixed 90～120 minutes with 15～25rpm, then each composition evenly distributes gradually.
Application step is gold (Au) the particle,colloid solution of preparing in the above-mentioned mixture of powders sprayed solution preparation process while stirring, mixing, so that with respect to the weight of mixture of powders, above-mentioned gold (Au) particle,colloid solution 3～10 % by weight scopes, thereby the step that is coated with on the surface of each powder composition is carried out to the mode of jet surface gold (Au) particle,colloid solution of the mixture of powders that stirs, mixes with the automatic sprayer that utilizes the ormal weight of can spraying.
And, the reasons that the input weight of gold (Au) particle,colloid solution is decided to be 3～10 amount % scopes are: if its weight surpasses 10 % by weight with respect to the weight of mixture of powders, each the powder composition that then causes forming mixture of powders condenses into mutually bulk, so not only need through once other broken step, and dry too much time, the problems such as each powder composition interreaction of needing.And the input weight of gold (Au) particle,colloid solution is during less than 3 % by weight, because its amount is too small and can not mixture of powders all be sprayed evenly distributedly, so can not expect effective effect.
Drying steps be will be coated with in the application step step of mixture of powders drying of gold (Au) particle,colloid solution, this drying steps can or spray hot blast and selects in the hot air drying that carries out and carry out at the heat drying that carry out to the mixer heating.
After such drying steps finished, the distilled water that contains in gold (Au) particle,colloid solution all evaporated, and fine gold (Au) fundamental particle remains on each powder particle that consists of mixture of powders.
After above-mentioned drying steps finishes, the powder composition that forms is filled in the regulation container, packs, then finished the manufacture process according to powder dentifrice composition of the present invention.
On the other hand, contain in the situation of angelica powder, also carry out the angelica powders mixing.The angelica powders mixing is that the angelica powder of preparing by powder composition preparation process is put in the mixture of powders that has carried out drying steps, again carry out Agitation and mixing, the step that it is distributed equably, at this moment, with respect to all weight of mixture of powders, the angelica powder of input is 1～10 % by weight scope.
On the other hand, simple declaration by above-mentioned manufacture process manufacturing according to the using method that contains the powder dentifrice composition of gold particle of the present invention.
The character that contains the powder dentifrice composition of gold particle according to the present invention is the Powdered of light gray or nattierblue, must be attached to the toothpaste of paste in the past and used, but owing to also can play fully bactericidal action in the time of gargling of short time, therefore can use separately according to pulverous compositions of present embodiment.
Below, expression is according to preferred embodiment of the present invention, and such embodiment is in order to help understanding of the present invention and illustrative, and scope of the present invention is not limited to following embodiment.And, at first, mixture of powders is carried out experiment for the in vitro antibacterial ability of harmful bacteria, and halitosis is removed in experiment, dental plaque is removed ability and used sense, and then experiment has been coated with the in vitro antibacterial ability to harmful bacteria behind gold (Au) particle,colloid solution.
Below, specific embodiment is described.
(mixture of powders 1)
As shown in table 1 below, will be as gold particle (native gold) 0.0005 % by weight of antibacterial, as trichlorophenol 0.1 % by weight, Olibanum oil 0.1 % by weight, propolis extract 1.0 % by weight of sterilizing ability enhancing adjuvant, as the hexadecylpyridinium chloride of scavenger for dental scar
0.1 % by weight, xylitol 5 % by weight, saccharin sodium 0.002 % by weight as sweeting agent, lactose 85.98 % by weight as excipient, minty note powder 5.0 % by weight, Herba Menthae Rotundifoliae powder 2.0 % by weight as fumet, as hydroxyapatite 0.3 % by weight of brightening agent, mix and the dentifrice composition that makes powder as spirulina blue color 0.4 weight of coloring agent.
(mixture of powders 2)
As shown in table 1 below, will be as gold particle (native gold) 0.5 % by weight of antibacterial, as trichlorophenol 0.2 % by weight, propolis extract 1.5 % by weight of sterilizing ability enhancing adjuvant, as the hexadecylpyridinium chloride of scavenger for dental scar
0.2 % by weight, xylitol 3 % by weight, sorbitol powder 20 % by weight as sweeting agent, lactose 67.90 % by weight as excipient, minty note powder 5.0 % by weight, Herba Menthae Rotundifoliae powder 1.0 % by weight as fumet, as hydroxyapatite 0.5 % by weight of brightening agent, mix and the dentifrice composition that makes powder as spirulina blue color 0.4 weight of coloring agent.
(mixture of powders 3)
As shown in table 1 below, will be as gold particle (native gold) 1.0 % by weight of antibacterial, as trichlorophenol 0.3 % by weight, propolis extract 3 % by weight of sterilizing ability enhancing adjuvant, as the hexadecylpyridinium chloride of scavenger for dental scar
0.4 % by weight, saccharin sodium 0.03 % by weight, sorbitol powder 20 % by weight as sweeting agent, lactose 49.17 % by weight, silicon dioxide 20.0 % by weight as excipient, minty note powder 5.0 % by weight as fumet, as hydroxyapatite 0.7 % by weight of brightening agent, mix as spirulina blue color 0.4 weight of coloring agent and made the powder dentifrice composition.
(mixture of powders 4)
As shown in table 1 below, will be as gold particle (native gold) 1.2 % by weight of antibacterial, as trichlorophenol 0.5 % by weight, Olibanum oil 0.4 % by weight, propolis extract 4 % by weight of sterilizing ability enhancing adjuvant, as the hexadecylpyridinium chloride of scavenger for dental scar
0.5 % by weight, xylitol 10 % by weight, sorbitol powder 20 % by weight as sweeting agent, lactose 55.00 % by weight as excipient, minty note powder 2.0 % by weight, Herba Menthae Rotundifoliae powder 5 % by weight as fumet, as hydroxyapatite 1.0 % by weight of brightening agent, mix and the dentifrice composition that makes powder as spirulina blue color 0.4 weight of coloring agent.
(mixture of powders 5)
As shown in table 1 below, will be as sorbitol powder 20 % by weight of sweeting agent, lactose 73.10 % by weight as excipient, minty note powder 1.0 % by weight, Herba Menthae Rotundifoliae powder 5.0 % by weight as fumet, as hydroxyapatite 0.5 % by weight of brightening agent, mix and the dentifrice composition that makes powder as spirulina blue color 0.4 % by weight of coloring agent.
(mixture of powders 6)
As shown in table 1 below, will be as sorbitol powder 20 % by weight of sweeting agent, as lactose 74.10 % by weight of excipient, as minty note powder 5.0 % by weight of fumet, as hydroxyapatite 0.5 % by weight of brightening agent, mix and the toothpaste that makes powder as spirulina blue color 0.4 % by weight of coloring agent.
Table 1
Experimental example 1
Following experimental example 1 be each mixture of powders of experiment table 1 to the antibacterial ability of the organism of oral cavity harmful bacteria, the test strain that uses this moment has been suitable for and has made tooth send out Streptococcus mutans (Streptococcus mutans cariogenic; NCTC 10449), make companion actinomycetes Actinobacillus (the Actinobacillus actinomycetemcomitans of tooth generation periodontal; ATCC 29522) and Capnocytophaga ochracea (Capnocytophaga ochracea; ATCC 27827), make Fusobacterium nucleatum (the Fusobacterium nucleatum of tooth generation periodontal and halitosis; ATCC 25586).
Above-mentioned test strain is taken out from freezing keeping state, after being inoculated in nutrient broth (Nutrient broth), in 37 ℃ culture medium, cultivated 48 hours, after pre-incubated like this each test organisms liquid is inoculated in the nutrient broth of 100ml with 1% (v/v), after in culture medium, again cultivating 12-20 hour, be used for experiment.
In order to test, the initial value of suitable bacterial population (bacterial suspension number) is 106～107cell/ml, for this reason, from pre-incubated bacterium liquid, respectively get the sterile purified water that 1ml puts into respectively in advance the 100ml of sterilization, this as stock solution, is utilized after progressively dilution method dilutes, to be coated on separately on the solid medium, it was cultivated 24 hours, the colony of regeneration is counted, obtain the initial stage inoculum density.
On the other hand, the preparation of experimental liquid is that the compositions that mixture of powders 1～6 described above prepares like that is mixed in the sterile purified water with identical amount, prepares through long-time dissolving.
And, each experimental liquid of above-mentioned preparation is respectively got 1ml pour into respectively in each test strain of having adjusted the initial stage inoculum density, after 1 minute time, measure remaining bacterium number.The mensuration of bacterium number is carried out by the following method, namely, the stock solution that reclaims is diluted by dilution method progressively, be coated on the dull and stereotyped training base according to each extension rate, after in culture machine, cultivating, bacterium colony of each dull and stereotyped training base is counted, according to the minimizing of the bacterium number of remaining bacterium number whether to be determined, thereby measure antibacterial ability.By the concentration of such method utilization to the remaining bacterium number of initial stage inoculum density, obtain bacteriostasis rate (%) with percentage rate, with this bacteriostasis rate (%) arrangement antibacterial ability (sterilizing ability), then as described in Table 2.
Table 2
As shown in table 2, example 1 as can be known by experiment: the content of gold particle is in the following comparative example 1 of 0.0005 % by weight, sterilizing ability for all test strains is significantly low, when making the content of gold particle increase to 1 % by weight from 0.0005 % by weight, sterilizing ability increases gradually, when surpassing 1 % by weight, sterilizing ability does not change.In addition, do not contain as can be known hexadecylpyridinium chloride fully
Mixture of powders 5 and 6 sterilizing ability significantly low.
As a result, the content that can confirm gold particle is 0.0005 % by weight～1 % by weight, contains hexadecylpyridinium chloride
In the situation, sterilizing ability is excellent.
Experimental example 2
Following experimental example 2 is the compositionss to the mixture of powders 1～6 of making according to the ratio of components of above-mentioned table 1 expression, use with each 10 object by name of men and women of growing up respectively, to removing halitosis, remove dental plaque, using sense to implement organoleptic examination, its meansigma methods is shown in following table 3 according to 5 point scale methods.
Table 3
| Inspection item | Mixture of powders 1 | Mixture of powders 2 | Mixture of powders 3 | Mixture of powders 4 | Mixture of powders 5 | Mixture of powders 6 |
| Remove halitosis | ?1.1 | ?3.9 | ?4.4 | ?4.0 | ?0.8 | ?0.8 |
| Remove dental plaque | ?3.0 | ?4.1 | ?4.6 | ?4.5 | ?1.4 | ?1.4 |
| Use sense | ?4.1 | ?4.2 | ?4.1 | ?3.9 | ?3.1 | ?3.2 |
| On average | ?2.73 | ?4.01 | ?4.37 | ?4.13 | ?1.76 | ?1.80 |
＜very 5,4, general 3, differ from 2, non-constant 1 〉
As shown in table 3, by above-mentioned experimental example 3 as can be known: the content right along with gold particle increases, and removes dental plaque and removes the halitosis raising, but use sense to reduce gradually, does not particularly add hexadecylpyridinium chloride
Mixture of powders 5 and 6 in, remove halitosis and remove the dental plaque effect significantly low.
As a result, example 3 can confirm that the content of gold particle is 0.0005 % by weight～1 % by weight, contains hexadecylpyridinium chloride by experiment
Situation under, can remove halitosis, remove dental plaque and use sense all to satisfy.
Experimental example 3
Following experimental example 3 is to confirm as in the sample of antibacterial ability excellence to select mixture of powders 2 in each mixture of powders of table 1, the gold colloid solution that concentration is different (20ppm, 30ppm, 50ppm, 60ppm, 70ppm) take with respect to the weight of mixture of powders 2 as the amount of 3 % by weight is coated with prepare after, carry out the in vitro sterilizing ability experiment to the oral cavity harmful bacteria, the result has obtained the result shown in the table 4.Experimental example 3 is to carry out according to the method identical with above-mentioned experimental example 1, but, to put in the sterile purified water with identical amount with the powder dentifrice composition that the mode that can confirm sterilizing ability when actual the gargling is made, but unlike experimental example 1, wait until fully dissolving, but each experimental liquid that will prepare immediately after stirring is respectively got 1ml and is poured into respectively in each test strain of having adjusted the initial stage inoculum density, after 1 minute time, measure remaining bacterium number.The mensuration of bacterium number is carried out by the following method, namely, the stock solution that reclaims is diluted by dilution method progressively, be coated on the dull and stereotyped training base according to each extension rate, after in culture machine, cultivating, bacterium colony of each dull and stereotyped training base is counted, according to the minimizing of the bacterium number of remaining bacterium number whether to be determined, thereby measure antibacterial ability.By such method utilization to the concentration of the remaining bacterium number of initial stage inoculum density with, percentage rate is obtained bacteriostasis rate (%), with this bacteriostasis rate (%) arrangement antibacterial ability (sterilizing ability).
Table 4
Example 3 fact as can be known is by experiment, and is as shown in table 4, is coated with in the situation of gold particle colloid solution, irrelevant with ratio, can relatively play effective bactericidal action in the short time.
But the concentration that can learn gold particle colloid solution is in the situation that 25ppm is following or 55ppm is above, the fact that the sterilizing ability of all test strains all descends.Former thereby speech with regard to it, the concentration of gold particle colloid solution is that 25ppm is when following, be judged as for the concentration of bactericidal action and cross low and can not carry out sufficient bactericidal action, the concentration of gold particle colloid solution is that 55ppm is when above, the size that is judged as along with gold particle becomes large relatively, little with the contact area of test strain, so sterilizing ability reduces.
By above-mentioned explanation the aforesaid powder dentifrice composition and the manufacture method thereof that contain gold particle according to preferred implementation of the present invention has been described, but this only illustrates, and those skilled in the art should be able to understand well in the scope that does not break away from technological thought of the present invention can carry out various variations and change.
Claims (2)
1. manufacture method that contains the powder dentifrice composition of gold particle wherein, comprising:
Powder composition preparation process, prepare respectively as the antibacterial that suppresses oral cavity bacterium, particle diameter is 10～200 mu m ranges and the gold particle that contains with 0.0005～1.0 % by weight scope, contain to be selected from hexadecylpyridinium chloride
0.1～0.5 % by weight, sodium fluoride 0.01～0.05 % by weight, 1 kind or 2 kinds scavenger for dental scar in sodium monofluorophosphate 0.1～0.7 % by weight, contain and be selected from trichlorophenol 0.01～0.5 % by weight, Olibanum oil 0.01～0.5 % by weight, the sterilizing ability more than a kind in propolis extract powder 0.1～5 % by weight strengthens adjuvant, contain and be selected from xylitol powder 1.0～10 % by weight, saccharin sodium 0.01～1.0 % by weight, the sweeting agent more than a kind in sorbitol powder 2.0～30 % by weight, contain and be selected from lactose 50.0～86.0 % by weight, the excipient more than a kind in silica 1 9.0～75.0 % by weight, and the fumet that contains with the surplus % by weight of described each composition, brightening agent, coloring agent, and the content sum of each composition is 100 % by weight;
The solution preparation process injects sterile purified water in electrolysis bath, purity is set is 99.9% gold rod, and coming the concentration of Reserve Fund particle by electrolytic process is the gold particle colloid solution of 25～55ppm;
Mixture forms step, forms mixture of powders on one side make described each powder composition of preparing in the described powder preparation process drop into mixer by 20～30 purpose sieves on one side;
Application step, spray described gold particle colloid solution while stirring, mix described mixture of powders, so that with respect to the weight of described mixture of powders, described gold particle colloid solution is 3～10 % by weight scopes, thereby is coated with on the surface of described each powder composition; And
Drying steps carries out drying with the mixture of powders that has been coated with described gold particle colloid solution in the described application step.
2. the manufacture method that contains the powder dentifrice composition of gold particle according to claim 1, wherein, after implementing described drying steps, also comprise the angelica powders mixing, described angelica powders mixing comprises: drop into the angelica powder, so that with respect to all weight of described mixture of powders, described angelica powder is 1～10 % by weight scope, and evenly mix.
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| KR1020100069361A KR101229174B1 (en) | 2010-07-19 | 2010-07-19 | Powder-type dentifrice composition contained gold particles and manufacturing method thereof |
| KR10-2010-0069361 | 2010-07-19 |
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| JP3991812B2 (en) * | 2001-12-11 | 2007-10-17 | 住友化学株式会社 | Ester compounds and uses thereof |
| KR20020033659A (en) * | 2002-01-28 | 2002-05-07 | 박동인 | a salt grass tooth powder |
| KR20080101955A (en) * | 2007-05-17 | 2008-11-24 | 김기영 | Powder-type dentifrice composition contained gold particles |
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