KR20120062030A - Powder-type dentifrice composition contained gold particles and manufacturing method thereof - Google Patents

Abstract

PURPOSE: A powder toothpaste composition containing gold particles is provided to disinfect bacteria without side effect and to prevent dental caries and gingival disorders. CONSTITUTION: A powder toothpaste composition contains 0.0005-1.0 Wt% of gold particles with a particle size of 10-200um; one or two kinds of plaque removers selected from 0.1-0.5 wt% of cetyl pyridinium chlorie, 0.01-0.05 wt% of sodium fluoride, and 0.1-0.7 wt% of sodium monofluorophosphate; an auxiliary disinfectant containing one or more selected from 0.01-0.5 wt% of triclosan, 0.01-0.5 wt% of mastic oil, and 0.1-5 wt% of propolis extract powder; one or more sweetener selected from 1.0-10 wt% of xylitol powder, 0.01-1.0 wt% of saccharin, and 2.0-3.0 wt% of sorbitol powder; and one or more excipients selected from 50.0-86.0 wt% of lactose and 19.0-75.0 wt% of silicon dioxide.

Description

Powder Toothpaste Composition Containing Gold Particles and Manufacturing Method Thereof {POWDER-TYPE DENTIFRICE COMPOSITION CONTAINED GOLD PARTICLES AND MANUFACTURING METHOD THEREOF}

The present invention relates to a powder toothpaste composition containing gold particles and a method for manufacturing the same, and more particularly, using a unique property of the gold (Au) component to perform sterilization without side effects in the oral cavity, but within a short time Even if applied as a powder toothpaste can be carried out by performing a practical bactericidal action, to prevent tooth decay and gum disease and to improve the effect of removing bad breath powder powder composition and a method for manufacturing the same will be.

In general, paste toothpaste is widely used as a toothpaste used for cleaning mouth and teeth, but if a long time is used or a certain time elapses with the lid of the tube open, the front part of the tube is hardened and not easily squeezed. It often became unusable. In addition, the toothpaste remaining inside the tube in the process of use can not be used completely, because the tube in which the toothpaste is injected as a single disposable, wasteful, causing environmental pollution.

In order to solve such a problem, a toothpaste can be used relatively, and a liquid toothpaste has been proposed. However, such a liquid toothpaste is not actually used due to the problem that the liquid toothpaste composition flows easily during use and is very inconvenient and wasteful.

On the other hand, powder toothpaste has recently been proposed as a solution to the problems of the paste toothpaste and liquid toothpaste as described above. Such powder toothpaste includes germanium oxide powder having a purity of 99% or more, as shown in "Toothpaste Composition containing Germanium Oxide Powder" of Korean Patent Publication No. 10-0614685, to pores having a specific porosity unique to germanium oxide. Toothpaste composition has been proposed that can increase the scale effect of removing tartar on the surface of the tooth.

In addition, as shown in the "powdered herbal toothpaste" of the Republic of Korea Patent Publication No. 10-2006-0102681, powdered salt and bamboo salt, talc powder, McManseok, herbal medicines to exert the effect of plaque removal or oral protection , Powdered toothpaste has been proposed to protect tooth enamel, and the effective effect of far-infrared radiation emitted from elvanite, such as "powdery toothpaste containing ganbanite as far-infrared radiation source" of Korean Patent Publication No. 10-2006-0008509 Powder toothpaste is presented.

In addition, as shown in the "Preparation method of powdered toothpaste for preventing and treating cavities, tooth decay, tooth rootitis, etc." of the Republic of Korea Patent Publication No. 1997-0069019, by mixing salt powder, roasted flake powder, rosin powder, etc. Powder toothpaste is also proposed to prevent and treat gum disease, especially flavor, tooth decay root tooth.

However, the conventional powder toothpaste as described above may have a certain effect in its own way, such as the removal effect of the scale, plaque removal effect, and gum disease, but the sterilizing power is weak and could not be expected to be effective enough to remove oral plaque and oral bacteria.

Accordingly, the chemical additives to perform the sterilization action has to be added, causing problems or irritating the skin of the sensitive oral cavity. For example, fluorides, which are widely used for toothpaste in toothpaste, could effectively prevent tooth decay and inhibit bacteria, but they could not exert relatively appropriate sterilizing effect on the gums or the skin inside the mouth. There is a problem that causes a spot on the teeth or cause discomfort to the consumer due to the smell of the drug.

In order to solve the above problems, the applicant has proposed a powder toothpaste composition containing the gold particles disclosed in Korean Patent Application No. 2007-0048135.

Powder toothpaste composition containing gold particles proposed by the Republic of Korea Patent Application No. 2007-0048135 is 0.0005 ~ 1% by weight of gold particles; Cetylpyridinium chloride powder 0.1 to 5% by weight; Ubide carenone (coenzyme Q10) powder 0.0001 to 2% by weight; 0.1-5% by weight of propolis extract powder; 0.5-2% by weight of hydroxyapatite powder; Sorbitol powder 2.0-30 wt%; And 10 to 80 wt% of one or more excipient powders selected from the group consisting of silicon dioxide, hydrous silicic acid, lactose and titanium oxide as excipients.

Since the powdered toothpaste composition containing the gold particles is enhanced by the inherent bactericidal action of the gold component, the sterilization power in the oral cavity is strengthened, and thus the effect of preventing tooth decay and gum disease was expected. Then, the above-described powder dentifrice composition was dissolved in sterile distilled water in the same amount, dissolved, and then poured into the test strain. After 1 minute of elapsed time, the remaining bacterial count was measured to have excellent sterilizing and antibacterial activity.

However, the above-described sterilization and antimicrobial test was performed by dissolving the powder toothpaste composition in a solvent (sterile distilled water) for a relatively long time and then measuring the sterilization power. Therefore, the use of the toothpaste actually did not take into account the characteristics of the powder toothpaste composition containing gold particles. When used as it was found to have a significant difference in sterilization power. That is, as a result of the sterilization test performed in the same manner in the powder toothpaste composition containing the gold particles in the solvent beforehand, it can be seen that the sterilization and antimicrobial activity is significantly reduced compared to the pre-dissolved, because of this Sufficient bactericidal effect could not be expected.

As a result of examining the reason, the powdered toothpaste composition containing particles is a toothpaste in powder form, so when brushing teeth, it takes time to dissolve the substances that exhibit sterilizing power, unlike paste toothpaste or liquid toothpaste, but it usually takes 3 minutes Since it was completed within a short time, it could not exhibit proper sterilizing power. Particularly, since gold particles, which are included as the main ingredient to exert bactericidal power, are natural substances with no side effects, they do not irritate or adversely affect the skin of sensitive oral skin and exclude chemicals added separately for sterilization so that no chemical smell occurs. However, it is a solid granule that is not easily dissolved, and since it has a certain limit in sterilization, it was necessary to supplement it.

The present invention has been conceived to solve the conventional problems as described above, by using the inherent properties of gold (Au) to perform the sterilization without side effects in the oral cavity, so as to perform the sterilization in a short time to powder toothpaste Even if applied as a practical sterilization effect, to prevent tooth decay and gum disease, and to provide a powder toothpaste composition containing gold particles to improve the effect of removing bad breath.

Powdered toothpaste composition containing gold particles for achieving the object of the present invention as described above, in the powdered toothpaste composition containing gold particles as an essential component, as a fungicide to suppress bacteria in the oral cavity 10 to 200 (㎛ ) And gold particles contained in the range 0.0005 to 1.0% by weight; A plaque remover containing one or two selected from 0.1 to 0.5% by weight of cetylpyridinium chloride, 0.01 to 0.05% by weight of sodium fluoride, and 0.1 to 0.7% by weight of sodium monofluorophosphate; Bactericidal power-enhancing adjuvant containing one or more selected from 0.01 to 0.5% by weight of triclosan, 0.01 to 0.5% by weight of mastic oil, and 0.1 to 5% by weight of propolis extract powder; Sweeteners containing at least one selected from 1.0 to 10% by weight of xylitol powder, 0.01 to 1.0% by weight of sodium saccharin, and 2.0 to 30% by weight of sorbitol powder; Excipients containing at least one selected from 50.0 to 86.0% by weight of lactose and 19.0 to 75.0% by weight of silicon dioxide; And a flavoring agent, a brightener, and a coloring agent, each of which is contained in the remaining weight% of each of the components, into a mixer to form a powder mixture, and stirring and mixing the powder mixture to the weight of the powder mixture. 3 to 10% by weight of gold (Au) is a gold (Au) particles colloidal solution having a concentration of 25 to 55ppm is sprayed evenly coated, characterized in that formed by drying.

In addition, the flavoring agent is selected by containing at least one selected from 1.0 to 5% by weight of peppermint flavor powder, 1.0 to 5.0% by weight of mint flavor, the brightener comprises hydroxyapatite in the range of 0.5 to 2% by weight, The colorant may contain spirulina or blue pigment in a range of 0.001 to 1.0% by weight.

On the other hand, the gold (Au) colloidal solution is formed by ionizing 99.9% gold (Au) rod in distilled water through an electrolysis process to form a small amount of gold (Au) particles of 0.001 to 0.015 micrometers (㎛) in distilled water. It is characterized by.

In addition, after coating and drying the gold (Au) particle colloidal solution, the grasswort powder may be further included to be in a range of 1 to 10% by weight based on the total weight of the powder mixture.

The method for producing a powdered toothpaste composition containing gold particles for achieving the object of the present invention as described above, in the method for producing a powdered toothpaste composition containing the particles as an essential component, the particle size as a fungicide to suppress oral bacteria Gold particles contained in the range of 10 to 200 (μm) and in the range of 0.0005 to 1.0% by weight, 0.1 to 0.5% by weight of cetylpyridinium chloride, 0.01 to 0.05% by weight of sodium fluoride, and 0.1 to 0.7% by weight of sodium monofluorophosphate A bactericidal enhancer, xylitol, in which at least one of two or more selected is contained and selected from 0.01 to 0.5% by weight of triclosan, 0.01 to 0.5% by weight of mastic oil, and 0.1 to 5% by weight of propolis extract powder. A sweetener containing at least one selected from 1.0 to 10% by weight of powder, 0.01 to 1.0% by weight of sodium saccharin, and 2.0 to 30% by weight of sorbitol powder, lactose 50.0 to 86.0% by weight, And at least one excipient selected from among 19.0 to 75.0 wt% of silicon oxide, and a powder component preparation step of preparing a flavoring agent, a brightening agent, and a coloring agent, respectively, which are contained in the remaining weight% of the respective components.

In addition, a solution preparation step of preparing a gold (Au) particle colloidal solution having a concentration of 25 to 55 ppm of gold (Au) particles through electrolysis by injecting sterile distilled water into an electrolytic cell and installing a 99.9% pure gold (Au) rod. ; A mixture formation step of forming a powder mixture by introducing each powder component prepared in the powder preparation step into a mixer while passing through 20 to 30 mesh; Coating the surface of each powder component by spraying the gold (Au) particle colloidal solution in a range of 3 to 10% by weight based on the weight of the powder mixture while stirring and mixing the powder mixture; And a drying step of drying the powder mixture coated with the gold (Au) particle colloidal solution in the coating step.

In addition, after performing the drying step may further include a mixing step to mix evenly by putting the persimmon (鹹 草) powder to be in a range of 1 to 10% by weight relative to the total weight of the powder mixture.

According to the powdered toothpaste composition containing the gold particles according to the present invention as described above, by the inherent bactericidal action of the gold component is strengthened in the oral disinfection, the effect of preventing tooth decay and gum disease is improved, cetyl chloride The addition of dinium improves sterilization and bad breath.

In particular, the powder toothpaste composition containing the gold particles according to the present invention has excellent sterilization effect and after the composition of the powder mixture to improve the prevention effect of caries and gum disease after the gold (Au) particles to perform the sterilization action within a short time By coating and drying the gold (Au) particle colloidal solution having a concentration in the range of about 25 to 55 ppm and the particle size of about 0.001 to 0.015 micrometers (μm) to each powder component, practical sterilization is performed even when applied as a powder toothpaste. It can work.

Hereinafter, the powdered toothpaste composition containing the gold particles according to the present invention will be described in detail based on the manufacturing technology of the powdered toothpaste, and the composition and operation and effects thereof can be easily understood by those skilled in the art from the related art. The detailed description is briefly omitted or omitted and described based on the parts related to the present invention.

Powdered toothpaste composition containing gold particles according to the present invention contains all the ingredients consisting of gold particles, plaque remover, bactericidal enhancer, sweetener, excipient, flavoring agent, brightener, and coloring agent contained as a fungicide to inhibit oral bacteria. It was put in a mixer to form a powder mixture, while stirring and mixing the powder mixture, a gold (Au) particle colloidal solution having a concentration of 3 to 10% by weight based on the weight of the powder mixture and 25 to 55 ppm of gold (Au) particles. Spray evenly to coat, dry to form.

Hereinafter, each component forming the powder mixture will be described in detail.

The gold particles act to prevent the growth of plaque and prevent diseases in the oral cavity by inhibiting bacterial growth by enhancing the bactericidal power in the oral cavity due to the properties of the gold (Au) component, such as the sterilization of gold particles The gold ions emitted by the silver metal gold act on the metabolism, which causes the bacteria to breathe and digest.

In addition, the gold particles are due to the properties of the gold (Au) component to enhance the bactericidal power in the oral cavity to prevent tooth decay and prevent gum disease. It penetrates easily into cells and acts as a catalyst to stop the function of enzymes required for oxygen metabolism by bacteria, fungi, viruses, etc., and sterilizes the pathogens in a short time, thus functioning as a natural fungicide without side effects. The skin's physiological function and cell regeneration function are activated to detoxify damaged gum cells and detoxification is performed. The cations from gold smoothly release hormones to maintain skin health.

Preferably, gold particle | grains add the gold foil which formed metallic gold (Au) of purity 99.9% so that a particle diameter might be 10-200 micrometers.

In addition, the content of gold particles is preferably 0.0005 to 1% by weight relative to the total weight of the powder mixture, because if the amount is less than 0.0005% by weight of the bactericidal power is remarkably weak can not exert the effect of preventing the removal of plastics and oral diseases When the weight exceeds 1% by weight, it can be seen experimentally that the sterilization effect is no longer increased even if the content is added.

Plaque remover can be applied to ingredients such as cetylpyridinium chloride (CPC), sodium fluoride, sodium monofluorophosphate to remove plaque by inhibiting oral bacteria and to prevent oral disease and remove bad breath. The content contains one or two or more of cetylpyridinium chloride (CPC) 0.1 to 0.5% by weight, sodium fluoride 0.01 to 0.05% by weight and 0.1 to 0.7% by weight sodium monofluorophosphate relative to the total weight of the powder mixture. It is desirable to.

Antibacterial aids may be applied to natural antibiotics such as triclosan, mastic oil, propolis extract. At this time, it is preferable to mix 1 or more types from 0.01 to 0.5 weight% of triclosan, 0.01 to 0.5 weight% of mastic oil, and 0.1 to 5 weight% of propolis extract powder with respect to the total weight of the said powder mixture.

The sweetener is selected from xylitol, sodium saccharin, and sorbitol powder to prevent tooth decay, and contains at least one of xylitol powder 1.0-10 wt%, saccharin sodium 0.01-1.0 wt%, and sorbitol powder 2.0-30 wt%. It is preferable to contain.

The excipient is a substance added to form a powder toothpaste in a certain form, it is preferable to contain at least one of lactose 50.0 ~ 86.0% by weight, silicon dioxide 19.0 ~ 75.0% by weight.

A flavoring agent selects and contains 1 type from 1.0 to 5 weight% of mint flavor powder, and 1.0 to 5.0 weight% of mint flavor powder.

Brightener is a hydroxyapatite, the main component of human bone and tooth enamel, which fills minute defects of teeth and makes the teeth smooth and glossy. The range is 0.5 to 2% by weight.

The colorant is configured to contain spirulina blue pigment extracted from spirulina in the range of 0.001 to 1.0% by weight. Spirulina is a blue-green cyanobacteria, a type of cyano bacteria, a spring-shaped spiral prokaryotic microorganism without cell walls, which contains a lot of vitamins, which is highly sulfated, improves immunity by increasing resistance to bacterial infections in the oral cavity, and improves gum disease in the oral cavity. Chrorophyll, a chlorophyll, is a substance that has a strong bactericidal action and inhibits bacterial growth in the oral cavity.

The gold (Au) colloidal solution is formed by ionizing a 99.9% gold (Au) rod in distilled water through an electrolysis process to include gold (Au) small particles of about 0.001 to 0.015 micrometers (µm) in distilled water.

On the other hand, the powdered toothpaste composition containing the gold particles according to the present invention may further comprise a glasswort (鹹 草) powder. When contained in a trace amount of less than 1% by weight of the seaweed powder, there is a limit to the use of the effective ingredients, if more than 10% by weight as a toothpaste impairs the feeling of freshness or feel as a range of 1 to 10% by weight relative to the total weight of the powder mixture Be sure to

The seaweed grows in groups around the coast, Gaepul, and salt fields that the seawater of Korea's coast or island region touches, and is called the 'Tung node' because it is a big and protruding grass. The botanical classification is chenopodiaceae. It is a plant belonging to the beginning of the year, which is a land plant, which contains abundant minerals such as calcium, magnesium, potassium, iron and phosphorus, including salt dissolved in seawater, and performs effective action on teeth and gums.

In addition, the seaweed powder may be added after extraction and powdering by heating extraction method, but in the present embodiment, the collected seaweeds are washed and freeze-dried so as not to destroy the effective herbal ingredients contained in the seaweed. After that, the powdered one is added.

In particular, in order not to destroy the effective herbal ingredients contained in the seaweed as described below it is very important to add separately after the drying step to avoid exposure to heat.

And the particle size of the grade which each powder component which forms a powder mixture passes through the sieve (filtration net) of 20-50 mesh is preferable.

Hereinafter, a method for preparing a powder dentifrice composition containing gold particles according to a preferred embodiment of the present invention.

Method for producing a powder toothpaste composition containing gold particles according to the present invention, gold particles, plaque remover, bactericidal enhancer, sweeteners, excipients, flavoring agent, brightener, contained in the remaining weight% of each powder component, A powder component preparation step of preparing a colorant, a solution preparation step of preparing a gold (Au) particle colloidal solution, a mixture formation step of forming a powder mixture, and coating a gold (Au) particle colloidal solution on the surface of the powder component The coating step and the drying step of drying the powder mixture are carried out sequentially.

First, the powder component preparation step is a fungicide for inhibiting oral bacteria as described above, gold particles contained in the range of 0.0005 to 1.0% by weight, 0.1 to 0.5% by weight of cetylpyridinium chloride, 0.01 to 0.05% by weight of sodium fluoride, and One or two types of plaque remover selected from among 0.1 to 0.7% by weight of sodium fluorophosphate, 0.01 to 0.5% by weight of triclosan, 0.01 to 0.5% by weight of mastic oil, and 0.1 to 5% by weight of propolis extract powder The above-mentioned bactericidal enhancer, xylitol powder 1.0 to 10% by weight, saccharin sodium 0.01 to 1.0% by weight, sorbitol powder 2.0 to 30% by weight, one or more selected sweeteners contained, lactose 50.0 to 86.0% by weight, silicon dioxide 19.0 to One or more excipients selected from 75.0 wt%, and flavoring agents, brighteners and coloring agents, which are contained in the remaining wt% of the respective powder components, are prepared. .

Solution preparation step is to prepare a gold (Au) particle colloidal solution having a concentration of 25 to 55ppm of gold (Au) particles by injecting distilled water into the electrolytic cell and installing a 99.9% purity gold rod. When electrolysis is performed by installing a 99.9% pure gold (Au) rod in an electrolytic cell, the gold component of the gold (Au) rod is ionized and then granulated to exist in distilled water. In this case, gold has a tendency to ionize faster than silver (Ag), and when the concentration reaches about 25 ppm, the particles are granulated and present in distilled water and start to form a colloidal solution. Combined with each other, the size was found to increase.

In addition, in the present embodiment, when the electrolysis is performed such that the concentration of Au particles is in the range of about 25 to 55 ppm, the size of the gold particles included in the sterile distilled water is about 0.001 to 0.015 micrometers (μm). By using these small gold particles, it is configured to perform sterilization more quickly when brushing teeth.

Mixture forming step is a step of forming a powder mixture by passing each powder ingredient prepared in the powder ingredient preparation step to the mixer while first, the plaque remover, bactericidal enhancer, sweetener, and excipient about 30 mesh After filtering and filtering with a filter network of 2, peppermint flavor powder, mint flavor powder and one of the spirulina blue pigment filtered through 30 mesh and put into the mixer and then mixed at 90 minutes to 15 minutes at 15-25 rpm each The components are gradually distributed equally.

The coating step is a step of coating the surface of each powder component by spraying the gold (Au) particle colloidal solution prepared in the solution preparation step while stirring and mixing the powder mixture in a range of 3 to 10% by weight based on the weight of the powder mixture. In this case, a gold (Au) particle colloidal solution is sprayed onto the surface of the powder mixture to be stirred and mixed by using an automatic sprayer capable of spraying a predetermined amount.

The reason why the input weight of the gold (Au) particle colloidal solution is set in the range of 3 to 10% by weight is that when the weight exceeds 10% by weight relative to the weight of the powder mixture, the respective powder components forming the powder mixture are entangled with each other. Since it becomes a lump form, not only has to go through a separate crushing process once again, it takes too much time for drying, which causes problems such as each powder component reacting with each other. In addition, when the input weight of the gold (Au) particle colloidal solution was less than 3% by weight, the amount thereof was too small to be evenly distributed in the powder mixture so that an effective action could not be expected.

The drying step is a step of drying the powder mixture coated with the gold (Au) particle colloid solution in the coating step. This drying step is selected from heat drying performed by applying heat to the mixer, or hot air drying performed by spraying hot air. Can be implemented.

When the drying step is completed, all distilled water contained in the gold (Au) particle colloid solution is evaporated and fine gold (Au) small particles remain in each powder particle constituting the powder mixture.

When the drying step described above is completed, the powder powder composition is packed in a predetermined container, and then the manufacturing process of the powder toothpaste composition according to the present invention is completed.

On the other hand, when it contains a seaweed powder, the seaweed powder mixing step is further performed. The mixing of the seaweed powder is a step of stirring and mixing the green seaweed powder prepared through the powder component preparation step into the powder mixture subjected to the drying step to distribute the powder evenly. To 1 to 10% by weight relative to the total weight of the.

On the other hand, it will be described briefly how to use the powdered toothpaste composition containing the gold particles according to the present invention prepared through the manufacturing process as described above.

The powder toothpaste composition containing the gold particles according to the present invention is a light gray or light blue powder, which is conventionally used by being attached to a paste-like toothpaste, but it performs sterilization sufficiently even for a short time brushing time. The powdery composition according to the present invention can be used alone.

Hereinafter, preferred embodiments according to the present invention, these examples are illustrated to help the understanding of the present invention and the scope of the present invention is not limited by the following examples. First, the in vitro antimicrobial activity against harmful bacteria was tested on the powder mixture, bad breath removal ability, plaque removal ability, and feeling test were performed, and the in vitro antimicrobial activity against harmful bacteria after coating the gold (Au) particle colloidal solution was tested. It was.

Hereinafter, specific examples will be described.

(Powder mixture 1)

As shown in Table 1 below, 0.0005% by weight of gold particles (gold leaf) as a bactericide, 0.1% by weight of triclosan, 0.1% by weight of mastic oil, 1.0% by weight of propolis extract, and 0.1% of cetylpyridinium chloride as a plaque remover. 5% by weight xylitol as a sweetener, 0.002% by weight sodium saccharin, 85.98% by weight lactose as excipient, 5.0% by weight mint flavor powder as flavoring agent, 2.0% by weight mint flavor powder, 0.3% by weight hydroxyapatite as brightener, colorant As a powder toothpaste composition was prepared by mixing 0.4 wt% of spirulina and blue pigment.

(Powder mixture 2)

As shown in Table 1 below, 0.5% by weight of gold particles (gold leaf) as a disinfectant, 0.2% by weight of triclosan as a bactericidal enhancer, 1.5% by weight of propolis extract, 0.2% by weight of cetylpyridinium chloride as a plaque remover, and xylitol as a sweetener 3 20 wt% sorbitol powder, 67.90 wt% lactose as excipient, 5.0 wt% peppermint flavor powder as flavoring agent, 1.0 wt% mint flavor powder, 0.5 wt% hydroxyapatite as brightener, 0.4 wt% spirulina and blue pigment as colorant To powder powder composition was prepared.

(Powder mixture 3)

As shown in Table 1 below, 1.0% by weight of gold particles (gold leaf) as a bactericide, 0.3% by weight of triclosan as a bactericidal enhancer, 3% by weight of propolis extract, 0.4% by weight of cetylpyridinium chloride as a plaque remover, sodium saccharin as a sweetener 0.03% by weight, 20% by weight of sorbitol powder, 49.17% by weight of lactose as excipient, 20.0% by weight of silicon dioxide, 5.0% by weight of peppermint flavor powder as flavoring agent, 0.7% by weight of hydroxyapatite as brightener, 0.4% by weight of spirulina or blue pigment as colorant To powder powder composition was prepared.

(Powder mixture 4)

As shown in Table 1 below, 1.2% by weight of gold particles (gold leaf) as a bactericide, 0.5% by weight of triclosan, 0.4% by weight of mastic oil, 4% by weight of propolis extract, and 0.5% cetylpyridinium chloride as a plaque remover Wt%, xylitol 10% by weight, sorbitol powder 20% by weight, lactose 55.00% as excipient, peppermint flavor powder 2.0% by weight, mint flavor powder 5% by weight, hydroxyapatite 1.0% by weight, colorant As a powder toothpaste composition was prepared by mixing 0.4 wt% of spirulina and blue pigment.

(Powder mixture 5)

As shown in Table 1 below, 20% by weight of sorbitol powder as a sweetening agent, 73.10% by weight of lactose as excipient, 1.0% by weight of peppermint flavor powder, 5.0% by weight of mint flavor powder, 0.5% by weight of hydroxyapatite as brightener, colorant As a powder toothpaste composition was prepared by mixing 0.4% by weight of spirulina and blue pigment.

(Powder mixture 6)

As shown in Table 1 below, 20% by weight of sorbitol powder as a sweetener, 74.10% by weight of lactose as excipient, 5.0% by weight of peppermint flavor powder as a flavoring agent, 0.5% by weight of hydroxyapatite as an additive, and 0.4% by weight of spirulina or blue pigment as colorant Powder Toothpaste was prepared by mixing.

Experimental Example 1

Experimental Example 1 below is to test the in vitro antimicrobial activity of the oral harmful bacteria of each powder mixture of Table 1, the test strain used at this time Streptococcus mutans (NCTC 10449) and the caries generated tooth, Actinobacillus actinomycetemcomitans (ATCC 29522) and Capnocytophaga ochracea (ATCC 27827), which cause periodontal disease, and Peugeot bacterium nucleatum, which cause periodontal disease and bad breath (Fusobacterium nucleatum; ATCC 25586) was applied.

The test strains were taken out of the frozen storage state, inoculated in Nutrient broth, and then incubated for 48 hours in a 37 ° C. incubator. Incubation for 12-20 hours in the incubator after 1% (v / v) inoculation was used for the experiment.

The initial bacterial suspension number for the test is 106 ~ 107 cell / ml. To this end, 1 ml of pre-cultivated bacterial solution is added to 100 ml of sterile distilled water, which is pre-sterilized. After dilution, each was plated in a solid medium and cultured for 24 hours to count the regenerated colonies to determine the initial inoculation concentration.

On the other hand, the preparation of the test solution was prepared by dissolving the composition prepared in the same manner as the powder mixtures 1 to 6 described above in sterile distilled water and dissolving it for a long time.

Then, 1 ml of each test solution prepared as described above was poured into each of the test strains at which the initial inoculation concentration was adjusted, and after 1 minute of elapsed time, the remaining bacterial count was measured. The bacterial count was measured by diluting the recovered stock solution by the step dilution method, spreading it on a plate medium for each dilution fold, incubating in the incubator, and counting the colonies of each plate medium to determine whether the number of bacteria was reduced according to the number of remaining bacteria. . In this way, the antimicrobial activity (sterilization power) is summarized as Table 2 below, as a percentage of the microbial fungi obtained as a percentage by the concentration of the remaining bacteria to the initial inoculation concentration.

As can be seen from Experimental Example 1, as shown in Table 2, in Comparative Example 1 in which the content of gold particles is 0.0005% by weight or less, the bactericidal power is significantly lower in all test strains. When the amount is increased from 0.0005% by weight to 1% by weight, the sterilization power gradually increases, but when it exceeds 1% by weight, it can be seen that there is no change in the sterilization power. It can also be seen that powder mixtures 5 and 6, which contain no cetylpyridinium chloride at all, have a significantly lower bactericidal power.

As a result, when the content of gold particles is 0.0005% by weight to 1% by weight, and it contains cetylpyridinium chloride, it can be confirmed that the bactericidal power is excellent.

Experimental Example 2

Experimental Example 2 below is to use the composition of the powder mixtures 1 to 6 prepared in accordance with the composition ratio shown in Table 1 to each adult 10 men and women, and to remove the bad breath, plaque, feeling in a five-point scale method According to the sensory test, the average value is shown in Table 3 below.

As can be seen from the above Experimental Example 3, as shown in Table 3, it can be seen that as the content of the gold particles increases, the removal of plaque and the bad breath are improved, but the feeling gradually decreases. It can be seen that in the powder mixtures 5 and 6 without pyridinium addition, the bad breath removal and plaque removal effects are remarkably low.

As a result, it can be confirmed from Experimental Example 3 that the content of gold particles is 0.0005% by weight to 1% by weight, and when the cetylpyridinium chloride is contained, all of bad breath removal, plaque removal, and usability can be satisfied.

Experimental Example 3

Experimental Example 3 below selects powder mixture 2 from among the powder mixtures of Table 1, which are found to have excellent antimicrobial activity, and selects gold colloidal solutions having different concentrations (20ppm, 25ppm, 45ppm, 55ppm, 70ppm) of powder mixture 2. After coating and preparing in an amount of 3% by weight based on the weight, the in vitro bactericidal power against oral harmful bacteria was tested, and the results as shown in Table 4 were obtained. Experimental Example 3 was carried out in the same manner as Experimental Example 1 described above, but in the same amount of the powdered toothpaste composition prepared in sterile distilled water so as to confirm the bactericidal power during substantial brushing, but wait until completely dissolved as in Experimental Example 1 After stirring without stirring, 1 ml of each test solution prepared immediately was poured into each test strain at which the initial inoculation concentration was adjusted, and after 1 minute elapsed, the remaining bacterial count was measured. The bacterial count was measured by diluting the recovered stock solution by the step dilution method, spreading it on a plate medium for each dilution fold, incubating in the incubator, and counting the colonies of each plate medium to determine whether the number of bacteria was reduced according to the number of remaining bacteria. . In this way, the antimicrobial activity (sterilization power) was summarized as the percentage of microbial fungi obtained as a percentage by the concentration of the remaining bacteria to the initial inoculation concentration.

As can be seen from Experiment 3, it can be seen that, as shown in Table 4, when the gold particle colloidal solution is coated, effective sterilization is performed within a relatively short time regardless of the ratio.

However, it can be seen that the bactericidal power of all test strains is poor when the concentration of the colloidal gold particles is less than 25ppm or more than 55ppm. The reason is that when the concentration of the gold particle colloidal solution is 25ppm or less, the concentration for sterilization is too low to perform sufficient sterilization, and when the concentration of the gold particle colloidal solution is 55ppm or more, the size of the gold fine particles is relatively high. As it becomes larger, the contact area with the test strain becomes smaller, so that the sterilizing power is deteriorated.

As described above, the powder toothpaste composition containing the gold particles according to a preferred embodiment of the present invention and a manufacturing method thereof are shown in accordance with the above description and drawings, but this is merely described for example and the technical spirit of the present invention. Those skilled in the art will appreciate that various changes and modifications can be made without departing.

Claims (6)

In powdered toothpaste composition containing gold particles as an essential component, Gold particles containing a particle diameter in the range of 10 to 200 (㎛) and 0.0005 to 1.0% by weight as a fungicide to inhibit bacteria in the oral cavity; A plaque remover containing one or two selected from 0.1 to 0.5% by weight of cetylpyridinium chloride, 0.01 to 0.05% by weight of sodium fluoride, and 0.1 to 0.7% by weight of sodium monofluorophosphate; Bactericidal enhancement aids in which at least one selected from 0.01 to 0.5% by weight of triclosan, 0.01 to 0.5% by weight of mastic oil, and 0.1 to 5% by weight of propolis extract powder is selected and contained; Sweeteners containing at least one selected from 1.0 to 10% by weight of xylitol powder, 0.01 to 1.0% by weight of sodium saccharin, and 2.0 to 30% by weight of sorbitol powder; Excipients containing at least one selected from 50.0 to 86.0% by weight of lactose and 19.0 to 75.0% by weight of silicon dioxide; And Injecting each of the components consisting of a flavoring agent, a brightener, a coloring agent contained in the remaining weight% of each component to a mixer to form a powder mixture, While stirring and mixing the powder mixture, a gold (Au) particle colloidal solution having a concentration of 3 to 10% by weight based on the weight of the powder mixture and a concentration of 25 to 55 ppm of gold (Au) particles is evenly sprayed, coated, and formed. Powder toothpaste composition containing the gold particles as an essential ingredient, characterized in that. The method of claim 1, The flavoring agent is selected by containing one or more selected from 1.0 to 5% by weight peppermint powder, 1.0 to 5.0% by weight mint powder, The brightener comprises hydroxyapatite in the range of 0.5 to 2% by weight, A powder toothpaste composition comprising gold particles as an essential component, wherein the colorant contains spirulina and blue pigment in a range of 0.001 to 1.0% by weight. The method according to claim 1 or 2, The gold (Au) particle colloidal solution is ionized 99.9% gold (Au) rod in distilled water through an electrolysis process, characterized in that formed in the distilled water to contain gold (Au) small particles of about 0.001 to 0.015 micrometers (㎛). Powder toothpaste composition which has the gold particle as an essential component. The method of claim 3, After coating and drying the gold (Au) particle colloidal solution, the gold particles as essential components, characterized in that it further comprises a seaweed powder so as to be in the range of 1 to 10% by weight based on the total weight of the powder mixture. Powder toothpaste composition. In the method for producing a powdered toothpaste composition containing gold particles as an essential component, As a fungicide that suppresses bacteria in the oral cavity, the particle size ranges from 10 to 200 (μm) and contains gold particles in the range of 0.0005 to 1.0 wt%, cetylpyridinium chloride 0.1 to 0.5 wt%, sodium fluoride 0.01 to 0.05 wt%, monofluorine 1 or 2 or more types of plaque remover, 0.01-0.5 weight% of triclosan, 0.01-0.5 weight% of mastic oil, and 0.1-5 weight% of propolis extract powders which are selected and contained from 0.1 to 0.7 weight% of sodium phosphate. A sweetening agent to be selected and contained, at least one selected from among 1.0 to 10% by weight of xylitol powder, 0.01 to 1.0% by weight of saccharin sodium, 2.0 to 30% by weight of sorbitol powder, 50.0 to 86.0% by weight of lactose, 1 to 75.0% by weight of silicon dioxide excipients selected by containing at least one selected, and powdery to prepare a flavoring agent, a brightener, a coloring agent contained in the remaining weight% of each component Preparatory phase; A solution preparation step of preparing a gold (Au) particle colloidal solution having a concentration of 25 to 55 ppm of gold (Au) particles through electrolysis by injecting sterile distilled water into an electrolytic cell and installing a 99.9% pure gold (Au) rod; A mixture formation step of forming a powder mixture by introducing each powder component prepared in the powder preparation step into a mixer while passing through 20 to 30 mesh; Coating the surface of each powder component by spraying the gold (Au) particle colloidal solution in a range of 3 to 10% by weight based on the weight of the powder mixture while stirring and mixing the powder mixture; And Method for producing a powder toothpaste composition containing gold particles as an essential component, characterized in that it comprises a drying step of drying the powder mixture coated with the gold (Au) particle colloidal solution in the coating step. The method of claim 5, After the drying step, the powder containing the gold particles as an essential ingredient further comprises a mixing step of mixing the mixture with evenly by adding the persimmon powder so as to be in the range of 1 to 10% by weight based on the total weight of the powder mixture Process for preparing toothpaste composition.