CN102335110A - Powder toothpaste combination comprising Au particles and manufacturing method thereof - Google Patents
Powder toothpaste combination comprising Au particles and manufacturing method thereof Download PDFInfo
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- CN102335110A CN102335110A CN2011101930112A CN201110193011A CN102335110A CN 102335110 A CN102335110 A CN 102335110A CN 2011101930112 A CN2011101930112 A CN 2011101930112A CN 201110193011 A CN201110193011 A CN 201110193011A CN 102335110 A CN102335110 A CN 102335110A
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- China
- Prior art keywords
- weight
- powder
- powders
- gold particle
- mixture
- Prior art date
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- Granted
Links
- 239000000843 powder Substances 0.000 title claims abstract description 222
- 229910052737 gold Inorganic materials 0.000 title claims abstract description 123
- 239000002245 particle Substances 0.000 title claims abstract description 123
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
- 239000000606 toothpaste Substances 0.000 title abstract description 37
- 229940034610 toothpaste Drugs 0.000 title abstract description 37
- 239000000203 mixture Substances 0.000 claims abstract description 160
- 230000001954 sterilising effect Effects 0.000 claims abstract description 43
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 39
- 210000000214 mouth Anatomy 0.000 claims abstract description 24
- 238000001035 drying Methods 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 22
- 238000005282 brightening Methods 0.000 claims abstract description 19
- 239000003086 colorant Substances 0.000 claims abstract description 19
- 239000010931 gold Substances 0.000 claims description 162
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 121
- 230000000844 anti-bacterial effect Effects 0.000 claims description 54
- 239000000551 dentifrice Substances 0.000 claims description 43
- 239000000084 colloidal system Substances 0.000 claims description 36
- 241000125175 Angelica Species 0.000 claims description 26
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 26
- 241000894006 Bacteria Species 0.000 claims description 25
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 19
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 16
- 239000002671 adjuvant Substances 0.000 claims description 15
- 239000002516 radical scavenger Substances 0.000 claims description 15
- 231100000241 scar Toxicity 0.000 claims description 15
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 14
- 240000002900 Arthrospira platensis Species 0.000 claims description 13
- 235000016425 Arthrospira platensis Nutrition 0.000 claims description 13
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 13
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 13
- 239000008101 lactose Substances 0.000 claims description 13
- 239000000600 sorbitol Substances 0.000 claims description 13
- 229940082787 spirulina Drugs 0.000 claims description 13
- 241000241413 Propolis Species 0.000 claims description 12
- 229940069949 propolis Drugs 0.000 claims description 12
- HSQFVBWFPBKHEB-UHFFFAOYSA-N 2,3,4-trichlorophenol Chemical compound OC1=CC=C(Cl)C(Cl)=C1Cl HSQFVBWFPBKHEB-UHFFFAOYSA-N 0.000 claims description 11
- 238000013459 approach Methods 0.000 claims description 11
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 10
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 10
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 10
- 239000000811 xylitol Substances 0.000 claims description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 10
- 229960002675 xylitol Drugs 0.000 claims description 10
- 235000010447 xylitol Nutrition 0.000 claims description 10
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 9
- 241000717739 Boswellia sacra Species 0.000 claims description 9
- 239000004863 Frankincense Substances 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 229940085605 saccharin sodium Drugs 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000005868 electrolysis reaction Methods 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 8
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 7
- 239000011775 sodium fluoride Substances 0.000 claims description 7
- 235000013024 sodium fluoride Nutrition 0.000 claims description 7
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 7
- 239000007921 spray Substances 0.000 claims description 6
- -1 While stirring Substances 0.000 claims description 2
- 240000006409 Acacia auriculiformis Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 29
- 208000002064 Dental Plaque Diseases 0.000 abstract description 13
- 206010006326 Breath odour Diseases 0.000 abstract description 12
- 208000024693 gingival disease Diseases 0.000 abstract description 10
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 3
- 208000010641 Tooth disease Diseases 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract 4
- 239000012752 auxiliary agent Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 235000019605 sweet taste sensations Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 33
- 208000032139 Halitosis Diseases 0.000 description 11
- 208000002925 dental caries Diseases 0.000 description 11
- 238000012360 testing method Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 10
- 230000002265 prevention Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 230000009931 harmful effect Effects 0.000 description 5
- 239000002054 inoculum Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 238000012549 training Methods 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000003113 dilution method Methods 0.000 description 3
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium oxide Inorganic materials O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- PVADDRMAFCOOPC-UHFFFAOYSA-N oxogermanium Chemical compound [Ge]=O PVADDRMAFCOOPC-UHFFFAOYSA-N 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 241000219317 Amaranthaceae Species 0.000 description 2
- 241000190885 Capnocytophaga ochracea Species 0.000 description 2
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 241000605986 Fusobacterium nucleatum Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000017471 coenzyme Q10 Nutrition 0.000 description 2
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000003239 periodontal effect Effects 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 239000013535 sea water Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000606750 Actinobacillus Species 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000192700 Cyanobacteria Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000018035 Dental disease Diseases 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000014151 Stomatognathic disease Diseases 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 206010044029 Tooth deposit Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 229910001573 adamantine Inorganic materials 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000011425 bamboo Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229940110767 coenzyme Q10 Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000007602 hot air drying Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 238000009288 screen filtration Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000037204 skin physiology Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960004747 ubidecarenone Drugs 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/60—Sugars, e.g. mono-, di-, tri-, tetra-saccharides
- A23V2250/64—Sugar alcohols
- A23V2250/6422—Xylitol
Abstract
The invention relates to a powder toothpaste combination comprising Au particles and a manufacturing method thereof, and in more detail, provides a powder toothpaste combination comprising Au particles and a manufacturing method thereof advantaged by taking effect of sterilization via use of inherent property of a Au ingredient having no side effect in the oral cavity, and taking effect of sterilization in short time, thereby taking effect of substantial sterilization as powder toothpaste for use, preventing decayed teeth and gum disease, and improving effect of eliminating bad breath. The powder toothpaste combination comprising Au particles is formed via the following method: ingredients of Au particles, a tooth plaque removing agent, a sterilization capability enhancing auxiliary agent, a sweet taste agent, a form-giving agent, a flavouring agent, a brightening agent, and a coloring agent are thrown into a mixer to form a powder mixture, the powder mixture is stirred and mixed while a Au particle colloidal solution is uniformly injected so as to perform coating and drying, and the powder toothpaste combination is formed.
Description
Technical field
The present invention relates to contain the powder dentifrice composition and the manufacturing approach thereof of gold particle, relate in more detail utilize gold (Au) thus the inherent character of composition plays bactericidal action with in the oral cavity, being free from side effects, and can play bactericidal action at short notice and be suitable for the powder dentifrice composition and the manufacturing approach thereof that contain gold particle that also can play substantial bactericidal action, caries prevention and gingival disease and can improve removing halitosis effect as powder toothpaste.
Background technology
Generally, for the cleaning of oral cavity and tooth and the toothpaste that the uses paste toothpaste that is widely used, but use for a long time or the lid of opening pipe through certain hour, then the fore-end of pipe solidify and be not easy to extrude or out of use situation more.In addition, in use, can not the inner residual toothpaste of pipe be used up fully, the pipe that has injected toothpaste can only be thrown away as disposable pipe at every turn, so waste is serious, exists and causes environmental pollution problems.
In order to solve such problem, can use toothpaste more carefully, and propose to reuse the liquid toothpaste of container.But so liquid toothpaste is when it uses, and has outflow and the very inconvenience of use easily of liquid dentifrice composition, wastes serious problem, so in reality, use.
On the other hand, the scheme as the problem that is used to solve above-mentioned paste toothpaste and liquid toothpaste has proposed powder toothpaste recently.As such powder toothpaste; Shown in " dentifrice composition that contains the germanium oxide powder " of korean granted patent communique patent No. 10-0614685 number; Having proposed to contain purity is the germanium oxide powder more than 99%, thereby can improve the dentifrice composition of the descale effect of the dental calculus that utilizes the distinctive porous space of germanium oxide to remove dental surface.
And; Shown in " the powder Chinese prescription toothpaste " of Korea S's publication communique publication number 10-2006-0102681 number; Propose powder salt, bamboo salt, Pulvis Talci, Maifanitum, Chinese drugs powderization brought into play the effect of removing dental plaque or protection oral cavity, and can protect adamantine powder toothpaste; " containing the powder toothpaste as the Maifanitum in far infrared irradiation source " that Korea S's publication communique publication number is 10-2006-0008509 number proposed to have brought into play from the powder toothpaste of effective effect of the far infrared of Maifanitum radiation.
In addition; Shown in " manufacturing approach of the powder toothpaste of prevention and treatment periodontitis, dental caries, apicitis etc. " of special 1997-0069019 number of Korea S publication communique publication number; Propose the salt-mixture powder, fried Semen Gleditsiae powder, Colophonium powder etc.; The powder toothpaste of prevention and treatment tooth or gum disease, particularly periodontitis, dental caries, apicitis etc.
Yet; Though removing aspects such as effect and gum disease at descale effect, dental plaque, above-mentioned powder toothpaste in the past can bring into play certain effect separately; But because a little less than the sterilizing ability, so in the oral cavity, can not expect effect of sufficient in the removing of the removing of dental plaque and oral cavity bacterium.
For this reason, need to drop into the chemical additive that plays bactericidal action, therefore taken place to cause stimulating the skin in responsive oral cavity or bringing dysgenic problem.For example; In toothpaste for bactericidal action widely used fluoride preparation; Though can play the dental caries of prophylaxis of teeth or the function of inhibition antibacterial effectively; But the inner skin of gingiva or oral cavity for supports tooth relatively can not be brought into play good bactericidal effect, and existence brings unhappy problem owing to making tooth generation speckle or medicine taste to consumer.
In order to address the above problem, the applicant has proposed 2007-0048135 number disclosed powder dentifrice composition that contains gold particle of korean patent application.
The powder dentifrice composition that contains gold particle that korean patent application proposes for 2007-0048135 number contains gold particle 0.0005～1 weight %; Hexadecylpyridinium chloride
powder 0.1～5 weight %; Ubidecarenone (coenzyme Q10) powder 0.0001～2 weight %; Propolis extract powder 0.1～5 weight %; Hydroxyapatite powder 0.5～2 weight %; Sorbitol powder 2.0～30 weight % and as excipient; Be selected from silicon dioxide; Moisture silicic acid; Lactose; Excipient powders 10～80 weight % of more than one in the titanium oxide and constituting.
The powder dentifrice composition that contains gold particle like this utilizes the inherent bactericidal action of golden composition and strengthens at intraoral sterilizing ability, thereby has played the effect of caries prevention and gum disease.And, be dissolved in sterile purified water with identical amount above-mentioned powder dentifrice composition after, pour in the test strain, after 1 minute time, measure remaining bacterium number, the result is determined as has excellent sterilizing ability and antibacterial ability.
But; Above-mentioned antibacterial and antibacterial ability test are the sterilizing abilities of in advance the powder dentifrice composition being measured after the long time is dissolved in solvent (sterile purified water); Therefore can know owing to there not be consideration to contain the characteristic in the use of powder dentifrice composition of gold particle, so compare difference when in fact using with suitable sterilizing ability as the purposes of toothpaste.Promptly; The powder dentifrice composition that will contain gold particle be not dissolved in advance solvent state under; Carry out BA according to identical method, therefore antibacterial as a result and antibacterial ability and carried out dissolved contrast in advance and significantly reduced can not expect sufficient bactericidal effect when gargling.
Studied its reason; The powder dentifrice composition that the result contains particle is the toothpaste of powder morphology; So it is different when gargling with paste toothpaste or liquid toothpaste; Need the material of performance sterilizing ability to carry out the dissolved time, but gargle owing to probably in 3 minutes, finishing, so can not bring into play sufficient sterilizing ability.The gold particle that particularly contains as the main component of bringing into play sterilizing ability is owing to be the natural materials of being free from side effects; Have the skin that does not stimulate responsive oral cavity or bring harmful effect, got rid of the chemical substance of adding in addition and do not produce the advantage of medicine taste for antibacterial; But be to be not easy dissolved solid granulates; In bactericidal action, have certain limit, therefore need replenish it.
Summary of the invention
The present invention is conceived to solve above-mentioned problem in the past; Purpose is to provide utilizes the inherent character of gold (Au) composition to play bactericidal action with in the oral cavity, being free from side effects, and can play bactericidal action at short notice, thereby even is suitable for the powder dentifrice composition that contains gold particle that also can play substantial bactericidal action, caries prevention and gingival disease and can improve removing halitosis effect as powder toothpaste.
The powder dentifrice composition that contains gold particle that is used to reach aforesaid the object of the invention is characterised in that; Form the powder dentifrice composition that contains gold particle through following method: will put into mixer by above-mentioned each composition that gold particle, scavenger for dental scar, sterilizing ability enhancing adjuvant, sweeting agent, excipient, fumet, brightening agent and coloring agent are formed and form mixture of powders; While stirring, mix the concentration that above-mentioned mixture of powders sprays gold (Au) particle equably is that gold (Au) the particle,colloid solution of 25～55ppm is coated with, and carries out drying and form; With respect to the weight of above-mentioned mixture of powders, above-mentioned gold (Au) particle,colloid solution is 3～10 weight %; Gold particle is as the antibacterial that suppresses antibacterial in the oral cavity, and its particle diameter is 10～200 mu m ranges, and contains with 0.0005～1.0 weight % scope; Scavenger for dental scar contains a kind or 2 kinds that is selected among hexadecylpyridinium chloride
0.1～0.5 weight %, sodium fluoride 0.01～0.05 weight %, sodium monofluorophosphate 0.1～0.7 weight %; Sterilizing ability strengthen adjuvant contain be selected among trichlorophenol 0.01～0.5 weight %, Olibanum oil 0.01～0.5 weight %, propolis extract powder 0.1～5 weight % more than a kind; Sweeting agent contain be selected among xylitol powder 1.0～10 weight %, saccharin sodium 0.01～1.0 weight %, sorbitol powder 2.0～30 weight % more than a kind; Excipient contain be selected among lactose 50.0～86.0 weight %, silica 1 9.0～75.0 weight % more than a kind; The surplus weight % that states each composition more than fumet, brightening agent, coloring agent are formed contains.
And; Above-mentioned fumet contain be selected among minty note powder 1.0～5 weight %, Herba Menthae Rotundifoliae powder 1.0～5.0 weight % more than a kind; Above-mentioned brightening agent contains the hydroxyapatite of 0.5～2 weight % scope, and above-mentioned coloring agent contains the spirulina blue color of 0.001～1.0 weight % scope.
On the other hand, above-mentioned gold (Au) particle,colloid solution is characterised in that the process through 99.9% gold medal of electrolysis in distilled water (Au) rod, carries out ionizing, thus in distilled water, contain 0.001～0.015 micron about (μ m) gold (Au) fundamental particle and form.
And, be coated with above-mentioned gold (Au) particle,colloid solution and drying after, can also contain the angelica powder, with respect to the total weight of above-mentioned mixture of powders, above-mentioned angelica powder is 1～10 weight % scope.
Be used for reaching the manufacturing approach of the powder dentifrice composition that contains gold particle of aforesaid the object of the invention; Possess: powder composition preparation process; Promptly; Prepare respectively as the antibacterial that suppresses oral cavity bacterium, particle diameter is 10～200 mu m ranges and the gold particle that contains with 0.0005～1.0 weight % scope; Contain a kind or 2 kinds scavenger for dental scar being selected among hexadecylpyridinium chloride
0.1～0.5 weight %, sodium fluoride 0.01～0.05 weight %, sodium monofluorophosphate 0.1～0.7 weight %; Contain the sterilizing ability more than a kind that is selected among trichlorophenol 0.01～0.5 weight %, Olibanum oil 0.01～0.5 weight %, propolis extract powder 0.1～5 weight % and strengthen adjuvant; Contain the sweeting agent more than a kind that is selected among xylitol powder 1.0～10 weight %, saccharin sodium 0.01～1.0 weight %, sorbitol powder 2.0～30 weight %; Contain the excipient more than a kind that is selected among lactose 50.0～86.0 weight %, silica 1 9.0～75.0 weight %, and the fumet, brightening agent, the coloring agent that contain with the surplus weight % of above-mentioned each composition.
And; The manufacturing approach that contains the powder dentifrice composition of gold particle also comprises: the solution preparation process; In electrolysis bath, inject sterile purified water; Purity is set is 99.9% gold (Au) rod, coming the concentration of Reserve Fund (Au) particle through electrolytic process is gold (Au) the particle,colloid solution of 25～55ppm; Mixture forms step, forms mixture of powders on one side make above-mentioned each powder composition of preparing in the above-mentioned powder preparation process drop into mixer through 20～30 purpose sieves on one side; Application step; Spray above-mentioned gold (Au) particle,colloid solution while stirring, mix said mixture of powders; Make that above-mentioned gold (Au) particle,colloid solution is 3～10 weight % scopes, thereby is coated with on the surface of above-mentioned each powder composition with respect to the weight of above-mentioned mixture of powders; And drying steps, the mixture of powders that has been coated with above-mentioned gold (Au) particle,colloid solution in the above-mentioned application step is carried out drying.
And, implement above-mentioned drying steps after, also comprise the angelica powders mixing; Said angelica powders mixing comprises: drop into the angelica powder; Make that above-mentioned angelica powder is 1～10 weight % scope, and uniform mixing with respect to all weight of above-mentioned mixture of powders.
Utilization is according to the above-mentioned powder dentifrice composition that contains gold particle of the present invention; Strengthen intraoral sterilizing ability through the inherent bactericidal action of golden composition; Can improve the preventive effect of dental caries and gum disease; And owing to added hexadecylpyridinium chloride
, so sterilizing ability and removing halitosis effect further improve.
Particularly; After the mode that the powder dentifrice composition that contains gold particle according to the present invention is excellent with bactericidal action, the preventive effect of dental caries and gum disease improves makes up mixture of powders; With the concentration of gold (Au) particle is that the size of scope, particle about 25～55ppm is that 0.001～0.015 micron gold (Au) particle,colloid solution coat about (μ m) is in each powder composition and carry out drying; Make and to carry out bactericidal action at short notice, thereby be suitable for the effect that also can play substantial bactericidal action even have as powder toothpaste.
The specific embodiment
Below; Utilize the manufacturing technology of powder toothpaste to specify according to the powder dentifrice composition that contains gold particle of the present invention; Utilizing the structure that prior art in the past learns easily and the detailed description of effect and effect thereof to carry out simple declaration or omission to those skilled in the art, is that the center describes with the part relevant with the present invention.
The powder dentifrice composition that contains gold particle according to the present invention is all the components that is made up of the gold particle that contains as the antibacterial that suppresses oral cavity bacterium, scavenger for dental scar, sterilizing ability enhancing adjuvant, sweeting agent, excipient, fumet, brightening agent and coloring agent to be dropped in the mixer form mixture of powders; While stirring, mix the concentration that this mixture of powders sprays gold (Au) particle equably is that gold (Au) the particle,colloid solution of 25～55ppm is coated with, and carries out drying and form; With respect to the weight of mixture of powders, above-mentioned gold (Au) particle,colloid solution is 3～10 weight %.
Below, each composition that forms mixture of powders is specifically studied.
The character that above-mentioned gold particle becomes branch to have owing to gold (Au) makes at intraoral sterilizing ability and strengthens; Suppress bacterial multiplication; Play the effect of removing dental plaque and prevention disease in mouth, the bactericidal action of such gold particle is a metabolism such as the breathing that acts on antibacterial of gold ion that Aurum metallicum discharges, digestion and play bactericidal action.
And above-mentioned gold particle is owing to the character that gold (Au) becomes branch to have is strengthened intraoral sterilizing ability, thereby plays the effect of caries prevention and gingival disease; As extensive known; Gold particle is penetrated in the skin or cell of human body easily, plays the effect of the catalyst of the function of needed enzyme when suppressing fungus, antibacterial or virus etc. and carrying out oxygen metabolism, kills above-mentioned pathogen etc. at short notice; Therefore play the function of the natural bactericidal agent of being free from side effects; In addition, activation skin physiology function and cell regeneration function play the recovery and the Detoxication of the gingival cell of damage; The cation of from gold, coming out makes the secretion of hormone smooth and easy, plays the effect of keeping intraoral skin health.
Preferably, gold particle is that adding purity is the native gold that 99.9% Aurum metallicum (Au) forms particle diameter 10～200 μ m.
In addition; The content of gold particle is 0.0005～1 weight % with respect to the total weight of above-mentioned mixture of powders preferably; This reason can be learnt by experiment: if be that then sterilizing ability significantly weakens below the 0.0005 weight %, thereby can not bring into play the preventive effect of removing dental plaque and disease in mouth; If when its weight surpassed 1 weight %, even appended its content, bactericidal effect can further not increase yet.
Scavenger for dental scar can be suitable for hexadecylpyridinium chloride
(CPC), the inhibition oral cavity bacterium of sodium fluoride, sodium monofluorophosphate and so on and remove dental plaque, and performance disease in mouth prevention and remove the composition of the effect of halitosis.Its content preferably with respect to the total weight of above-mentioned mixture of powders contain hexadecylpyridinium chloride
(CPC) among 0.1～0.5 weight %, sodium fluoride 0.01～0.05 weight %, sodium monofluorophosphate 0.1～0.7 weight % more than a kind or 2 kinds.
Sterilizing ability strengthens the natural antibiotics that adjuvant can be suitable for trichlorophenol, Olibanum oil, propolis extract and so on.At this moment, preferred mixed phase is for the overall weight of above-mentioned mixture of powders, among trichlorophenol 0.01～0.5 weight %, Olibanum oil 0.01～0.5 weight %, propolis extract powder 0.1～5 weight % more than a kind.
Sweeting agent is from can xylitol, saccharin sodium and the sorbitol powder of caries prevention, to select and contain, preferably contain among xylitol powder 1.0～10 weight %, saccharin sodium 0.01～1.0 weight %, sorbitol powder 2.0～30 weight % more than a kind.
Excipient is the material that adds in order to form powder toothpaste with certain form, preferably contain among lactose 50.0～86.0 weight %, silica 1 9.0～75.0 weight % more than a kind.
Fumet is from minty note powder 1.0～5 weight %, Herba Menthae Rotundifoliae powder 1.0～5.0 weight %, to select a kind and contain.
Brightening agent is suitable for the hydroxyapatite (Hydroxyapatite) of the main constituent that constitutes human skeleton and tooth enamel, plays the fine damaged part of filling tooth, makes that the smooth and glossiness effect of tooth, the scope of its content are 0.5～2 weight % scopes.
The extraction that coloring agent contains 0.001～1.0 weight % scope is from the spirulina blue color of spirulina (spirulina) and constitute.Spirulina is dark green blue algae, is a kind of of cyanobacteria, is the spiral type prokaryotic micro-organisms that does not have the spring-like of cell wall; Contain a large amount of vitamin,, improve the resistance of boil on the nape opposite the mouth intracavity bacterial infection so sulfonation is excellent; Thereby raising immunity; Prevent intraoral gum disease, have powerful bactericidal action, so be the material that suppresses oral cavity bacterium propagation as chlorophyllous CHLOROPHYLLINE.
Above-mentioned gold (Au) particle,colloid solution is to form through following method, that is, in distilled water, through the electrolytic process ionizing, make distilled water contain 0.001～0.015 micron gold (Au) fundamental particle about (μ m) 99.9% gold medal (Au) rod.
On the other hand, the powder dentifrice composition that contains gold particle according to the present invention can also contain the angelica powder.With regard to the angelica powder, when containing, limited in the utilization of effective ingredient less than 1 weight %; Be 10 weight % when above, impair frankness sense or usability as toothpaste, therefore with respect to the total weight of mixture of powders, the angelica powder is 1～10 weight % scope.
Angelica growth in flakes around in one's power seashore or mud bank of the geographic sea water of seashore or island of Korea S, salt pan; Owing to be the grass that plump and every joint is all given prominence to; So be also referred to as " fat joint ", on botany classification 1 year this plant of SHENGCAO that belongs to Chenopodiaceae (chenopodiaceae), as land plant; Contain abundant, to be dissolved in the sea water be the various mineral such as calcium, enzyme, potassium, ferrum, phosphorus of representative with salt, thereby to tooth or gingiva performance effective function.
And, the angelica powder can utilize the heating extraction mode extract and powdered after drop into, but in this embodiment; In order not destroy the effective crude drug composition that contains in the angelica, the angelica of collecting is cleaned, carry out lyophilization; Fragmentation drops into the angelica of powdered.
Particularly, importantly as following explanation, behind drying steps, drop in addition, it is not exposed in the steam in order not destroy the effective crude drug composition that contains in the angelica.
And each the powder composition that forms mixture of powders preferably can pass through the granularity of the degree of 20～50 purpose sieves (drainage screen).
Below, the manufacturing approach according to the powder dentifrice composition that contains gold particle of preferred implementation of the present invention is described.
The manufacturing approach that contains the powder dentifrice composition of gold particle according to the present invention is carried out following steps successively: Reserve Fund particle, scavenger for dental scar, sterilizing ability strengthen the powder composition preparation process of adjuvant, sweeting agent, excipient and the fumet that contains with the surplus weight % of above-mentioned each powder composition, brightening agent, coloring agent; The solution preparation process of Reserve Fund (Au) particle,colloid solution; The mixture that forms mixture of powders forms step; At the application step of the surface coated of powder composition gold (Au) particle,colloid solution, the drying steps of dry powder mixture.
At first; In powder composition preparation process, prepare respectively as stated: as the gold particle antibacterial that suppresses oral cavity bacterium, that contain with 0.0005～1.0 weight % scope; Contain a kind or 2 kinds scavenger for dental scar being selected among hexadecylpyridinium chloride
0.1～0.5 weight %, sodium fluoride 0.01～0.05 weight %, sodium monofluorophosphate 0.1～0.7 weight %; Contain the sterilizing ability more than a kind that is selected among trichlorophenol 0.01～0.5 weight %, Olibanum oil 0.01～0.5 weight %, propolis extract powder 0.1～5 weight % and strengthen adjuvant; Contain the sweeting agent more than a kind that is selected among xylitol powder 1.0～10 weight %, saccharin sodium 0.01～1.0 weight %, sorbitol powder 2.0～30 weight %; Contain the excipient more than a kind that is selected among lactose 50.0～86.0 weight %, silica 1 9.0～75.0 weight %, and the fumet, brightening agent, the coloring agent that contain with the surplus weight % of said each composition.
The solution preparation process is in electrolysis bath, to inject sterile purified water; Purity be set be 99.9% gold (Au) rod; Coming the concentration of Reserve Fund (Au) particle through electrolytic process is the step of gold (Au) the particle,colloid solution of 25～55ppm; Can know with purity to be that 99.9% gold (Au) rod is arranged on electrolysis bath and implements electrolysis, after the golden composition ionizing of gold (Au) rod, particlized and being present in the distilled water.At this moment, the ionization tendency of Jin Biyin (Ag) is fast, and when its concentration was roughly the 25ppm left and right sides, then particlized and being present in the distilled water began to form colloid solution, and when surpassing 55ppm, then gold particle deposition not only, and particle mutually combines, and its size increases.
And; In this embodiment; If electrolysis is the scope about 25～55ppm to the concentration of gold (Au) particle, the size of the gold particle that then contains in the sterile purified water is about 0.001～0.015 micron (μ m), through using the little fundamental particle of such particle diameter; When gargling, can more promptly play bactericidal action.
It is to make each powder composition of preparing in the above-mentioned powder composition preparation process put into the step that forms mixture of powders in the mixer on one side through sieve on one side that mixture forms step; At first; With scavenger for dental scar, sterilizing ability strengthen adjuvant, sweeting agent and excipient about with 30 orders the drainage screen filtration and drop into, mix; For the second time a kind in minty note powder, the Herba Menthae Rotundifoliae powder and spirulina blue color are filtered with 30 mesh and behind the input mixer; Mixed 90～120 minutes with 15～25rpm, then each composition uniform distribution gradually.
Application step is gold (Au) the particle,colloid solution of preparing in the above-mentioned mixture of powders sprayed solution preparation process while stirring, mixing; Feasible weight with respect to mixture of powders; Above-mentioned gold (Au) particle,colloid solution 3～10 weight % scopes; Thereby the step that is coated with on the surface of each powder composition is carried out to the mode of jet surface gold (Au) particle,colloid solution of stirring, blended mixture of powders with the automatic sprayer that utilizes the ormal weight of can spraying.
And; The reason that the input weight of gold (Au) particle,colloid solution is decided to be 3～10 amount % scopes is: if its weight surpasses 10 weight % with respect to the weight of mixture of powders; Each the powder composition that then causes forming mixture of powders condenses into bulk mutually; So not only need be through once other broken step, and drying needs too much time, problems such as each powder composition interreaction.And the input weight of gold (Au) particle,colloid solution is during less than 3 weight %, because its amount is too small and can not mixture of powders all be sprayed evenly distributedly, so can not expect effective function.
Drying steps is with the mixture of powders exsiccant step that has been coated with gold (Au) particle,colloid solution in the application step, and this drying steps can or spray hot blast and selects in the hot air drying that carries out and carry out at the heat drying that carry out to the mixer heating.
After such drying steps finished, the distilled water that contains in gold (Au) particle,colloid solution all evaporated, and fine gold (Au) fundamental particle remains on each powder particle that constitutes mixture of powders.
After above-mentioned drying steps finishes, the powder composition of forming is filled in the regulation container, packs, then accomplished manufacture process according to powder dentifrice composition of the present invention.
On the other hand, contain under the situation of angelica powder, also carry out the angelica powders mixing.The angelica powders mixing is that the angelica powder of preparing through powder composition preparation process is put in the mixture of powders that has carried out drying steps; Stir once more and mix; The step that it is distributed equably; At this moment, with respect to all weight of mixture of powders, the angelica powder of input is 1～10 weight % scope.
On the other hand, simple declaration through above-mentioned manufacture process manufacturing according to the method for using that contains the powder dentifrice composition of gold particle of the present invention.
The character that contains the powder dentifrice composition of gold particle according to the present invention is the Powdered of light gray or nattierblue; Must use attached to the toothpaste of paste in the past; But, therefore can use separately according to pulverous compositions of this embodiment owing to also can play bactericidal action fully in the time of gargling of short time.
Below, expression is according to preferred embodiment of the present invention, and such embodiment is in order to help understanding of the present invention and illustrative, and scope of the present invention is not limited to following embodiment.And; At first; Mixture of powders is directed against the experiment of the outer antibacterial ability of organism of harmful bacterium, and halitosis property is removed in experiment, dental plaque is removed ability and usability, and experiment has been coated with the outer antibacterial ability of the organism to harmful bacterium behind gold (Au) particle,colloid solution then.
Below, concrete embodiment is described.
(mixture of powders 1)
As shown in table 1 below; Will be as gold particle (native gold) the 0.0005 weight % of antibacterial; Strengthen trichlorophenol 0.1 weight %, Olibanum oil 0.1 weight %, the propolis extract 1.0 weight % of adjuvant as sterilizing ability; Hexadecylpyridinium chloride
0.1 weight % as scavenger for dental scar; Xylitol 5 weight %, saccharin sodium 0.002 weight % as sweeting agent; Lactose 85.98 weight % as excipient; As minty note powder 5.0 weight %, the Herba Menthae Rotundifoliae powder 2.0 weight % of fumet, the hydroxyapatite 0.3 weight % as brightening agent mixes and the dentifrice composition that makes powder as spirulina blue color 0.4 weight of coloring agent.
(mixture of powders 2)
As shown in table 1 below; Will be as gold particle (native gold) the 0.5 weight % of antibacterial; Strengthen trichlorophenol 0.2 weight %, the propolis extract 1.5 weight % of adjuvant as sterilizing ability; Hexadecylpyridinium chloride
0.2 weight % as scavenger for dental scar; Xylitol 3 weight %, sorbitol powder 20 weight % as sweeting agent; Lactose 67.90 weight % as excipient; As minty note powder 5.0 weight %, the Herba Menthae Rotundifoliae powder 1.0 weight % of fumet, the hydroxyapatite 0.5 weight % as brightening agent mixes and the dentifrice composition that makes powder as spirulina blue color 0.4 weight of coloring agent.
(mixture of powders 3)
As shown in table 1 below; Will be as gold particle (native gold) the 1.0 weight % of antibacterial; Strengthen trichlorophenol 0.3 weight %, the propolis extract 3 weight % of adjuvant as sterilizing ability; Hexadecylpyridinium chloride
0.4 weight % as scavenger for dental scar; Saccharin sodium 0.03 weight %, sorbitol powder 20 weight % as sweeting agent; Lactose 49.17 weight %, silicon dioxide 20.0 weight % as excipient; As the minty note powder 5.0 weight % of fumet,, mix as spirulina blue color 0.4 weight of coloring agent and made the powder dentifrice composition as the hydroxyapatite 0.7 weight % of brightening agent.
(mixture of powders 4)
As shown in table 1 below; Will be as gold particle (native gold) the 1.2 weight % of antibacterial; Strengthen trichlorophenol 0.5 weight %, Olibanum oil 0.4 weight %, the propolis extract 4 weight % of adjuvant as sterilizing ability; Hexadecylpyridinium chloride
0.5 weight % as scavenger for dental scar; Xylitol 10 weight %, sorbitol powder 20 weight % as sweeting agent; Lactose 55.00 weight % as excipient; As minty note powder 2.0 weight %, the Herba Menthae Rotundifoliae powder 5 weight % of fumet, the hydroxyapatite 1.0 weight % as brightening agent mix and the dentifrice composition that makes powder as spirulina blue color 0.4 weight of coloring agent.
(mixture of powders 5)
As shown in table 1 below; Will be as the sorbitol powder 20 weight % of sweeting agent; Lactose 73.10 weight % as excipient; As minty note powder 1.0 weight %, the Herba Menthae Rotundifoliae powder 5.0 weight % of fumet,, mix and the dentifrice composition that makes powder as the spirulina blue color 0.4 weight % of coloring agent as the hydroxyapatite 0.5 weight % of brightening agent.
(mixture of powders 6)
As shown in table 1 below; Will be as the sorbitol powder 20 weight % of sweeting agent; As the lactose 74.10 weight % of excipient, as the minty note powder 5.0 weight % of fumet; As the hydroxyapatite 0.5 weight % of brightening agent, mix and the toothpaste that makes powder as the spirulina blue color 0.4 weight % of coloring agent.
Table 1
Experimental example 1
Following experimental example 1 is the antibacterial ability of each mixture of powders of experiment table 1 to the organism of the harmful bacterium in oral cavity, and the test strain that use this moment has been suitable for Streptococcus mutans (the Streptococcus mutans that makes tooth generation dental caries; NCTC 10449), make companion actinomycetes Actinobacillus (the Actinobacillus actinomycetemcomitans of tooth generation periodontal; ATCC 29522) and Capnocytophaga ochracea (Capnocytophaga ochracea; ATCC 27827), make Fusobacterium nucleatum (the Fusobacterium nucleatum of tooth generation periodontal and halitosis; ATCC 25586).
Above-mentioned test strain is taken out from freezing keeping state; After being inoculated in nutrient broth (Nutrient broth); In 37 ℃ culture medium, cultivated 48 hours; After pre-incubated like this each test organisms liquid is inoculated in the nutrient broth of 100ml with 1% (v/v), in culture medium, after subculture 12-20 hour, be used for experiment.
In order to test, the initial value of suitable bacterial population (bacterial suspension number) is 106～107cell/ml, for this reason; From pre-incubated bacterium liquid, respectively get 1ml and put into the sterile purified water of germ-resistant 100ml in advance respectively, this as stock solution, is utilized after progressively dilution method dilutes; To be coated on separately on the solid medium; It was cultivated 24 hours, regenerated colony is counted, obtain the initial stage inoculum density.
On the other hand, the preparation of experimental liquid is that the compositions that as above-mentioned mixture of powders 1～6, prepares is mixed in the sterile purified water with identical amount, prepares through long-time dissolving.
And, each experimental liquid of above-mentioned preparation is respectively got 1ml pour into respectively in each test strain of having adjusted the initial stage inoculum density, after 1 minute time, measure remaining bacterium number.The mensuration of bacterium number is carried out through following method; That is, the stock solution that reclaims is diluted through dilution method progressively, be coated on the dull and stereotyped training base according to each extension rate; After in the cultivation machine, cultivating; Bacterium colony of each dull and stereotyped training base is counted, whether to be confirmed, thereby measure antibacterial ability according to the minimizing of the bacterium number of remaining bacterium number.Through the concentration of such method utilization, obtain bacteriostasis rate (%) with percentage rate, with this bacteriostasis rate (%) arrangement antibacterial ability (sterilizing ability), then shown in below table 2 to the remaining bacterium number of initial stage inoculum density.
Table 2
As shown in table 2; Can know through experimental example 1: the content of gold particle is in the comparative example 1 below the 0.0005 weight %; Sterilizing ability for all test strains is significantly low, and the content that makes gold particle is when 0.0005 weight % increases to 1 weight %, and sterilizing ability increases gradually; When surpassing 1 weight %, sterilizing ability does not change.In addition, can know that the sterilizing ability of the mixture of powders 5 that do not contain hexadecylpyridinium chloride
fully and 6 is significantly low.
The result; The content that can confirm gold particle is 0.0005 weight %～1 weight %; Contain under hexadecylpyridinium chloride
situation, sterilizing ability is excellent.
Experimental example 2
Following experimental example 2 is the compositionss to the mixture of powders of making according to the ratio of components of above-mentioned table 1 expression 1～6; Use with each 10 object by name of men and women of growing up respectively; To removing halitosis, removing dental plaque, usability enforcement organoleptic examination, its meansigma methods is shown in below table 3 according to 5 point scale methods.
Table 3
| Inspection item | Mixture of powders 1 | Mixture of powders 2 | Mixture of powders 3 | Mixture of powders 4 | Mixture of powders 5 | Mixture of powders 6 |
| Remove halitosis | ?1.1 | ?3.9 | ?4.4 | ?4.0 | ?0.8 | ?0.8 |
| Remove dental plaque | ?3.0 | ?4.1 | ?4.6 | ?4.5 | ?1.4 | ?1.4 |
| Usability | ?4.1 | ?4.2 | ?4.1 | ?3.9 | ?3.1 | ?3.2 |
| On average | ?2.73 | ?4.01 | ?4.37 | ?4.13 | ?1.76 | ?1.80 |
< very good 5,4, general 3, as to differ from 2, non-constant 1 >
As shown in table 3; Can know through above-mentioned experimental example 3: the content right along with gold particle increases; Remove dental plaque and remove the halitosis raising; But usability reduces gradually; Particularly do not add in the mixture of powders 5 and 6 of hexadecylpyridinium chloride
, it is significantly low with removing dental plaque effect to remove halitosis.
The result; Can confirm that through experimental example 3 content of gold particle is 0.0005 weight %～1 weight %, contains under the situation of hexadecylpyridinium chloride
, can all satisfy removing halitosis, removing dental plaque and usability.
Experimental example 3
Following experimental example 3 is in each mixture of powders of table 1, to confirm as in the excellent sample of antibacterial ability to select mixture of powders 2; The gold colloid solution that concentration is different (20ppm, 30ppm, 50ppm, 60ppm, 70ppm) with the weight with respect to mixture of powders 2 be the amount of 3 weight % be coated with prepare after; Carry out the outer sterilizing ability experiment of the organism of the harmful bacterium in oral cavity, the result has obtained the result shown in the table 4.Experimental example 3 is according to carrying out with above-mentioned experimental example 1 identical method; But; To put in the sterile purified water with identical amount with the powder dentifrice composition that the mode that can confirm sterilizing ability when actual the gargling is made, but wait until dissolving fully, but each experimental liquid that after stirring, will prepare is immediately respectively got 1ml and poured into respectively in each test strain of having adjusted the initial stage inoculum density unlike experimental example 1 that kind; After 1 minute time, measure remaining bacterium number.The mensuration of bacterium number is carried out through following method; That is, the stock solution that reclaims is diluted through dilution method progressively, be coated on the dull and stereotyped training base according to each extension rate; After in the cultivation machine, cultivating; Bacterium colony of each dull and stereotyped training base is counted, whether to be confirmed, thereby measure antibacterial ability according to the minimizing of the bacterium number of remaining bacterium number.Through such method utilization to the concentration of the remaining bacterium number of initial stage inoculum density with, percentage rate is obtained bacteriostasis rate (%), with this bacteriostasis rate (%) arrangement antibacterial ability (sterilizing ability).
Table 4
The fact that can know through experimental example 3 is, and is as shown in table 4, is coated with under the situation of gold particle colloid solution, irrelevant with ratio, can play effective bactericidal action in the short time relatively.
But the concentration that can learn gold particle colloid solution is below the 25ppm or under the situation more than the 55ppm, the fact that the sterilizing ability of all test strains all descends.Former thereby speech with regard to it; The concentration of gold particle colloid solution is that 25ppm is when following; Be judged as the concentration that is used for bactericidal action and cross low and can not carry out sufficient bactericidal action, the concentration of gold particle colloid solution is 55ppm when above, and the size that is judged as along with gold particle becomes big relatively; Little with the contact area of test strain, so sterilizing ability reduces.
Through above-mentioned explanation the aforesaid powder dentifrice composition and the manufacturing approach thereof that contain gold particle according to preferred implementation of the present invention has been described; But this only illustrates, and those skilled in the art should be able to understand well in the scope that does not break away from technological thought of the present invention can carry out various variations and change.
Claims (6)
1. a powder dentifrice composition that contains gold particle is characterized in that, forms the powder dentifrice composition that contains gold particle through following method:
To strengthen said each composition that adjuvant, sweeting agent, excipient, fumet, brightening agent and coloring agent form by gold particle, scavenger for dental scar, sterilizing ability and put into mixer and form mixture of powders,
While stirring, mix concentration that said mixture of powders sprays gold particle equably is that the gold particle colloid solution of 25～55ppm is coated with, and carries out drying and form;
With respect to the weight of said mixture of powders, said gold particle colloid solution is 3～10 weight %;
Gold particle is as the antibacterial that suppresses antibacterial in the oral cavity, and its particle diameter is 10～200 mu m ranges, and contains with 0.0005～1.0 weight % scope;
Scavenger for dental scar contains a kind or 2 kinds that is selected among hexadecylpyridinium chloride
0.1～0.5 weight %, sodium fluoride 0.01～0.05 weight %, sodium monofluorophosphate 0.1～0.7 weight %;
Sterilizing ability strengthen adjuvant contain be selected among trichlorophenol 0.01～0.5 weight %, Olibanum oil 0.01～0.5 weight %, propolis extract powder 0.1～5 weight % more than a kind;
Sweeting agent contain be selected among xylitol powder 1.0～10 weight %, saccharin sodium 0.01～1.0 weight %, sorbitol powder 2.0～30 weight % more than a kind;
Excipient contain be selected among lactose 50.0～86.0 weight %, silica 1 9.0～75.0 weight % more than a kind;
Fumet, brightening agent, coloring agent contain with the surplus weight % of said each composition.
2. the powder dentifrice composition that contains gold particle according to claim 1, wherein,
Said fumet contain be selected among minty note powder 1.0～5 weight %, Herba Menthae Rotundifoliae powder 1.0～5.0 weight % more than a kind,
Said brightening agent contains the hydroxyapatite of 0.5～2 weight % scope,
Said coloring agent contains the spirulina blue color of 0.001～1.0 weight % scope.
3. the powder dentifrice composition that contains gold particle according to claim 1 and 2; Wherein, Said gold particle colloid solution is to form through following method, that is, and and through the process of 99.9% gold medal of electrolysis in distilled water rod; Carry out ionizing, thereby in distilled water, contain this particle of auri about 0.001～0.015 μ m.
4. the powder dentifrice composition that contains gold particle according to claim 3; Wherein, be coated with said gold particle colloid solution and drying after, also contain the angelica powder; With respect to the total weight of said mixture of powders, said angelica powder is 1～10 weight % scope.
5. manufacturing approach that contains the powder dentifrice composition of gold particle wherein, comprising:
Powder composition preparation process; Prepare respectively as the antibacterial that suppresses oral cavity bacterium, particle diameter is 10～200 mu m ranges and the gold particle that contains with 0.0005～1.0 weight % scope; Contain a kind or 2 kinds scavenger for dental scar being selected among hexadecylpyridinium chloride
0.1～0.5 weight %, sodium fluoride 0.01～0.05 weight %, sodium monofluorophosphate 0.1～0.7 weight %; Contain the sterilizing ability more than a kind that is selected among trichlorophenol 0.01～0.5 weight %, Olibanum oil 0.01～0.5 weight %, propolis extract powder 0.1～5 weight % and strengthen adjuvant; Contain the sweeting agent more than a kind that is selected among xylitol powder 1.0～10 weight %, saccharin sodium 0.01～1.0 weight %, sorbitol powder 2.0～30 weight %; Contain the excipient more than a kind that is selected among lactose 50.0～86.0 weight %, silica 1 9.0～75.0 weight %, and the fumet, brightening agent, the coloring agent that contain with the surplus weight % of said each composition;
The solution preparation process injects sterile purified water in electrolysis bath, purity is set is 99.9% gold rod, and coming the concentration of Reserve Fund particle through electrolytic process is the gold particle colloid solution of 25～55ppm;
Mixture forms step, forms mixture of powders on one side make said each powder composition of preparing in the said powder preparation process drop into mixer through 20～30 purpose sieves on one side;
Application step; Spray said gold particle colloid solution while stirring, mix said mixture of powders; Make that said gold particle colloid solution is 3～10 weight % scopes, thereby is coated with on the surface of said each powder composition with respect to the weight of said mixture of powders; And
Drying steps carries out drying with the mixture of powders that has been coated with said gold particle colloid solution in the said application step.
6. the manufacturing approach that contains the powder dentifrice composition of gold particle according to claim 5; Wherein, implement said drying steps after, also comprise the angelica powders mixing; Said angelica powders mixing comprises: drop into the angelica powder; Make that said angelica powder is 1～10 weight % scope, and uniform mixing with respect to all weight of said mixture of powders.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020100069361A KR101229174B1 (en) | 2010-07-19 | 2010-07-19 | Powder-type dentifrice composition contained gold particles and manufacturing method thereof |
| KR10-2010-0069361 | 2010-07-19 |
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| CN102335110A true CN102335110A (en) | 2012-02-01 |
| CN102335110B CN102335110B (en) | 2013-03-20 |
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| CN2011101930112A Active CN102335110B (en) | 2010-07-19 | 2011-07-06 | Powder toothpaste combination comprising Au particles and manufacturing method thereof |
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| KR (1) | KR101229174B1 (en) |
| CN (1) | CN102335110B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7002799B1 (en) | 2021-06-23 | 2022-01-20 | 株式会社東洋厚生製薬所 | Preventive or therapeutic agent for Alzheimer's disease |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030045530A (en) * | 2001-12-04 | 2003-06-11 | 김명중 | Toothpaste Which Contains Powdered Gold And Process For Preparing Thereof |
| KR100827193B1 (en) * | 2001-12-11 | 2008-05-02 | 스미또모 가가꾸 가부시키가이샤 | Cyclopropanecarboxylic Acid Esters and Pest Controllers Containing the Same |
| KR20080101955A (en) * | 2007-05-17 | 2008-11-24 | 김기영 | Powder-type dentifrice composition contained gold particles |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020033659A (en) * | 2002-01-28 | 2002-05-07 | 박동인 | a salt grass tooth powder |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030045530A (en) * | 2001-12-04 | 2003-06-11 | 김명중 | Toothpaste Which Contains Powdered Gold And Process For Preparing Thereof |
| KR100827193B1 (en) * | 2001-12-11 | 2008-05-02 | 스미또모 가가꾸 가부시키가이샤 | Cyclopropanecarboxylic Acid Esters and Pest Controllers Containing the Same |
| KR20080101955A (en) * | 2007-05-17 | 2008-11-24 | 김기영 | Powder-type dentifrice composition contained gold particles |
Non-Patent Citations (1)
| Title |
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| 无: "《纳米金溶液》", 《技术与市场》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7002799B1 (en) | 2021-06-23 | 2022-01-20 | 株式会社東洋厚生製薬所 | Preventive or therapeutic agent for Alzheimer's disease |
| JP2023003082A (en) * | 2021-06-23 | 2023-01-11 | 株式会社東洋厚生製薬所 | Agent for prevention or treatment of alzheimer-type dementia |
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| Publication number | Publication date |
|---|---|
| KR101229174B1 (en) | 2013-02-01 |
| CN102335110B (en) | 2013-03-20 |
| KR20120062030A (en) | 2012-06-14 |
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