KR101854418B1 - Toothpaste composition comprising jade ingredient - Google Patents

Abstract

The present invention provides a toothpaste composition. More specifically, the toothpaste composition comprises: 20-40 wt% of an abrasive; 20-40 wt% of a wetting agent comprising an aqueous sorbitol solution and glycerine; 1-10 wt% of a binder comprising xanthan gum and sodium carboxymethylcellulose; 0.1-5 wt% of a surfactant comprising N-lauroyl glutamic acid monosodium; 0.1-2 wt% of a sweetener comprising stevioside; 0.01-2 wt% of perfume comprising peppermint oils; 10-25 wt% of medicinal components comprising allantoin chlorohydroxy aluminum, aminocaproic acid, xylitol, an extract of Houttuynia cordata, an extract of Sophora flavescenes, an extract of grapefruit seeds, a green tea extract, myrrh, jade enzyme salt, aloe vera gel, and mastic; and a balance amount of natural alkaline reduced water of pH 7.5-8.5. The toothpaste composition of the present invention provides excellent effects for toothache, periodontitis, halitosis, and the like.

Description

TOOTHPASTE COMPOSITION COMPRISING JADE INGREDIENT [0002]

The present invention relates to a dentifrice composition comprising an ox component.

Typical oral hygiene agents can be classified as toothpaste, toothpaste, film, and spray. The purpose of these oral products is to be esthetic such as oral whitening, prevention of dental deposition, halitosis suppression, and treatment and prevention of tooth decay and gum disease.

Toothpaste is a complex material that is used as a toothbrush to clean and polish teeth. It is made of powder, cream or liquid. Toothpastes are made to help prevent or treat disinfection, tartar dissolution, odor decay, and tooth decay.

As a component of toothpaste, an abrasive may be mentioned first. Examples of the abrasive include calcium carbonate, calcium phosphate, calcium sulfate, magnesium carbonate, magnesium chloride and the like. These are useful for mechanical cleaning of teeth. If the size, hardness, and shape of the particles are not appropriate, there is a risk of damaging the surface of the teeth. Therefore, the size of the particles should be approximately 1 to 20 μm, Not to be sensitive, hardness is about 3 degrees of moss hardness is required.

In addition to the abrasive, the toothpaste contains a small amount of a detergent, a fragrance, a pigment, a disinfectant, a tartar solution, and a neutralizer. In addition to the cream type, a bonding agent, a stabilizer and the like are added.

In recent years, toothpastes containing specific substances such as bamboo salt, antiplasmin, allantoin derivatives, vitamin ester, elvan, mica and ceramics have been developed in order to increase the sterilizing power for the prevention of the antibacterial and inflammation in the oral cavity. .

However, even with the inclusion of the above-mentioned components, the expected effect is not obtained.

Korean Patent No. 10-0348155

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned disadvantages of the prior art,

It is an object of the present invention to provide a dentifrice composition which not only improves the efficacy of the jade component itself but also enhances the activity of other active ingredients by the effect of far infrared ray emitted from the jade ingredient .

It is another object of the present invention to provide a dentifrice composition which provides an excellent effect such as toothache, periodontitis, halitosis and the like by containing an effective pharmaceutical ingredient.

It is another object of the present invention to provide a dentifrice composition which is excellent in taste (taste).

It is another object of the present invention to provide a dentifrice composition which can effectively prevent precipitation of the jade powder which can be caused by the inclusion of the jade powder.

The present invention, in order to achieve the above object,

20 to 40% by weight of abrasive; 20 to 40% by weight of a wetting agent comprising an aqueous solution of sorbitol and glycerin; 1 to 10% by weight of a binder comprising xanthan gum and carboxymethylcellulose sodium; 0.1 to 5% by weight of a surfactant comprising sodium N-lauroyl glutamate; 0.1 to 2% by weight of a sweetener comprising stearic acid; 0.01 to 2% by weight of a perfume containing peppermint oil; 10 to 25% by weight of a pharmaceutical composition containing allantoin chlorohydroxy aluminum, aminocaproic acid, xylitol, horseradish extract, gossam extract, grapefruit seed extract, green tea extract, myrrh powder, aloe vera gel, and mastic; And a remaining amount of natural alkali reduced water having a pH of 7.5 to 8.5.

The dentifrice composition of the present invention not only improves the efficacy of toothpaste by itself but also enhances the activity of other active ingredients due to the effect of far infrared ray emitted from the jade component, Gingivitis, bad breath and the like.

In addition, the dentifrice composition of the present invention contains an effective medicinal ingredient, thereby providing excellent effects such as toothache, periodontitis, halitosis and the like.

In addition, the dentifrice composition of the present invention provides excellent aesthetics (taste feeling).

In addition, the dentifrice composition of the present invention is excellent in storage stability by effectively preventing precipitation of the jade powder which may be caused by the inclusion of the jade powder.

Hereinafter, the present invention will be described in detail.

The present invention relates to an abrasive comprising 20 to 40% by weight of an abrasive; 20 to 40% by weight of a wetting agent comprising an aqueous solution of sorbitol and glycerin; 1 to 10% by weight of a binder comprising xanthan gum and carboxymethylcellulose sodium; 0.5 to 3% by weight of a surfactant comprising sodium N-lauroyl glutamate; 0.1 to 2% by weight of a sweetener comprising stearic acid; 0.01 to 2% by weight of a perfume containing peppermint oil; 10 to 25% by weight of a pharmaceutical composition containing allantoin chlorohydroxy aluminum, aminocaproic acid, xylitol, horseradish extract, gossam extract, grapefruit seed extract, green tea extract, myrrh powder, aloe vera gel, and mastic; And a remaining amount of natural alkaline reducing water having a pH of 7.5 to 8.5.

In the above,

(a) baking the salt for 1 to 2 hours;

(b) cooling the salt baked in step (a) to room temperature;

(c) spraying the enzyme solution on the cooled salt and drying;

(d) spraying 7.5 to 8.5 natural alkali reduced water on the salt sprayed with the enzyme solution and drying;

(e) aging the salt produced in said step; And

(f) pulverizing the aged salt.

In the step (c), the enzyme solution is not particularly limited, and an enzyme useful for oral health as a known enzyme solution can be used without limitation.

In step (d), the natural alkali reduced water having a pH of 7.5 to 8.5 may be used as described in detail below.

In the step (e), the aging period is not particularly limited, and can be aged for an appropriate period of time, for example, from one week to three years.

The enzyme solution and the natural alkali reduced water having a pH of 7.5 to 8.5 can be sprayed in an amount of 2 to 10% by weight based on the total weight of the salt, respectively.

It is preferable that the natural alkali reduced water having the pH of 7.5 to 8.5 is groundwater produced in the jade mine area. The groundwater produced in the Jade Mine area is characterized by the mild nature of the water, its taste, and its clean nature. In addition, when people eat for a long time, the five-legged meat becomes rich, the waste in the body escapes, and the hair is not whitened. It is said that Chinese people have always been prone to jade because they have been directly influenced by the human body, stabilizing the nervous system and strengthening the functions of the five muscles.

Natural Alkali Reduced Water is water that is rarely known even in academia because it is rare in the world. In Korea or Japan, alkaline water is usually divided into alkaline water, which is produced by ionized water. Alkaline water is effective in chronic diarrhea, gastritis, gastric hyperplasia, dyspepsia, abnormal gastric fermentation, constipation, relieving fatigue, preventing colds, restoring appetite, hypertension, diabetes, allergies, rheumatism, relieving hangover, asthma and urticaria.

The pH of the natural alkali reduced water is more preferably 8.0 to 8.5.

The abrasive may include 20 to 70% by weight of the jade powder and 30 to 80% by weight of the silicon dioxide based on the total weight of the abrasive. The jade powder has an average particle size of 100 to 400 mesh, and preferably has a surface treated with a silane compound represented by the following formula (1):

[Chemical Formula 1]

Jade powder is used to remove stones and plaque attached to the teeth and to prevent tooth decay, whitening, and tooth decay. In addition to the above-mentioned effects, the jade powder can smooth the blood circulation of the gums when the teeth are brushed by the blood circulation promoting action, thereby providing the effect of making the mouth healthy. On the other hand, according to Dongyobo, if you take ogal to make it barely healthy, it will enrich the five-o'clock meat, let waste into the body, remove the heat of the stomach, and be effective in the digestive system. It lubricates the function, helps the voice of the vocal cords, and is described as good for the throat. In addition, when the scar is scratched on the face and the body according to the primordial gangbang, the main ingredient of the purgatory is matched with each element of the human body, such as scars are removed and the skin is moistened by rubbing the wound with the powder for several days without any side effects It is said to exert excellent effects on the human body. The taste of jade is sweet, calm and poisonous, and it has the effect of enriching the five-legged meat and releasing waste products in the body. The far-infrared rays inside the jade are effective for prevention of various adult diseases because the blood circulation of the body is energized and the heat is applied to the inside of the body. Further, the far-infrared rays function to maximize the activity of other components in the toothpaste.

Jade is divided into jadeite (jadeite) and nephrite (jadeite) by the difference of color and hardness in mineralogy. Nephritic purgative in China has been used for the treatment of various diseases since ancient times. This purgatory is a tungsten or tungchuan stone that is made of fine fibrous crystals intertwined with dense quality. Therefore, in the present invention, it is preferable to use a nephrite powder having a specific gravity of 2.9 to 3.0 and a hardness of 5.5 to 6.0, which has a low hardness in the furnace, as an octane powder. The value measured by the radiation sample tooth wear measurement method adopted in the United States or the United Kingdom as a standard method has a value of 250 or less. The average particle size of the above-mentioned jade powder is preferably 100 to 400 mesh, and if it is out of the above range, it will not function as an abrasive or the roughness of the product will become worse.

The jade powder can be produced by using a tundish treated with remnants or wastes derived from mining or gemstones disclosure.

The jade powder is contained in toothpaste and provides excellent effects as described above, but has a disadvantage that it does not go to the bottom because it is more dense than other components.

Therefore, in order to solve the above-mentioned disadvantages in the present invention, the surface of the jade powder is coated with a silane compound and used.

The coating of the surface of the jade powder with the silane compound is carried out by mixing the jade powder in water and stirring to prepare a slurry, adding the silane compound represented by the formula (1) to the slurry, stirring the mixture, .

The silane compound represented by the following formula (1) is preferably added in an amount of 5 to 20 parts by weight based on 100 parts by weight of the jute powder, and the stirring is preferably performed very strongly.

[Chemical Formula 1]

In the silane compound represented by Formula 1, the three methoxy groups bonded to Si are changed into three hydroxy groups in the slurry, and the three hydroxy groups are firmly bonded to the surface of the ox powder. In addition, succinic anhydride is cleaved in the slurry and converted into two carboxyl groups. The two carboxyl groups are mixed with water in toothpaste as a hydrophilic group so that the cornmeal is dispersed well.

The dentifrice composition of the present invention may further comprise 0.1 to 3% by weight of a brightener containing titanium oxide.

In addition, the dentifrice composition of the present invention may further contain a fluorine component. As the fluorine component, sodium fluoride, sodium monofluorophosphate, tin fluoride, amine fluoride, etc. may be used. Can be used in a concentration of 500 to 1,500 ppm.

In addition to the ingredients described above, additives commonly used in dentifrice compositions may be used without limitation as long as they do not violate the object of the present invention. For example, potassium nitrate, tricalcium phosphate (mitochondria), sodium lauryl sulfate (foaming agent) and the like may be further used.

The dentifrice composition of the present invention provides a dentifrice composition which is more excellent in inhibition of silylation by adjusting the pH to 7.0 to 8.5

Hereinafter, the active ingredient of the dentifrice composition will be described in detail.

In the present invention, the abrasive may contain 20 to 70% by weight of the jade powder and 30 to 80% by weight of the silicon dioxide based on the total weight of the abrasive. The composition of the abrasive should be adjusted in consideration of abrasive power, efficacy and effects of the teeth. The dentifrice composition of the present invention contains 20 to 40% by weight of the abrasive.

In the present invention, the wetting agent is used to prevent dryness of toothpaste on ointment by inhibiting moisture evaporation when toothpaste is exposed in the air, and includes 20 to 40% by weight of aqueous solution of sorbitol and glycerin.

In the present invention, the binder is combined with a liquid component such as an abrasive in the toothpaste to maintain the ointment phase, prevent the liquid component from being separated, and form a viscosity suitable for use. In the present invention, the binder includes xanthan gum and carboxymethylcellulose sodium, and is contained in an amount of 1 to 10% by weight.

In the present invention, the foaming agent serves to complement the cleaning action of the abrasive and generate bubbles to increase the feeling of brushing. In the present invention, the foaming agent includes sodium N-lauroyl glutamate and is contained in an amount of 0.5 to 3% by weight.

In addition, fragrances and sweeteners are used to enhance the feeling of brushing, and sweeteners including peppermint oil and stevioides are used. The fragrance and the sweetener are contained in an amount of 0.01 to 2% by weight and 0.1 to 2% by weight, respectively.

The present invention also provides a pharmaceutical composition comprising a medicinal ingredient comprising allantoin chlorohydroxy aluminum, aminocaproic acid, xylitol, horseradish extract, gossam extract, grapefruit seed extract, green tea extract, myrrh powder, aloe vera gel, 25% by weight.

The amount of each of the allantoin chlorohydroxy aluminum, aminocaproic acid, xylitol, horseradish extract, gossam extract, grapefruit seed extract, green tea extract, myrrh powder, aloe vera gel, and mastic is 1: 3: 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3: 1 to 3.

The allantoin chlorohydroxyaluminum and aminocaproic acid are used as anti-inflammatory agents and periodontal disease preventive agents.

The xylitol has a unique pentose structure that does not degrade the cavities and has the function of reducing the occurrence of cavities. Specifically, for example, mutans bacteria, which is a typical cavity-inducing bacteria, mistook xylitol similar to sugar with sugar, and xylitol was not digested by the bacteria to produce acid which is a cause of tooth damage, In the course of eating xylitol, consuming all of energy consumes energy and weakens activity, inhibiting the growth of tooth decay, reducing plaque formation, which is the bacterial membrane of the tooth surface, and inhibiting acid production, thereby reducing tooth decay.

The herbal extract is effective for the removal of inflammation and acts to elevate the effect of removing germs causing gum disease.

The gosam extract is added so as to have anti-inflammatory function like bamboo salt and aminocaproic acid. The gosam has a component called matrine which activates the intestinal motility of the intestines and is especially used for eczema and skin pyrexia. ≪ / RTI > pain and itching.

The major antimicrobial substances of the grapefruit seed extract are Naringin and Citral. Naringin is a component of flavonoids known as vitamin P, which is found mainly in the seeds and peels of ripe grapefruit seeds. Naringin has a bitter taste, and its molecular formula is C ₂₇ H ₃₂ 0 ₁₄ .2H ₂ O.

The green tea extract mainly contains components such as caffeine, organic acid, amino acid, (+) - catechin and saccharides. Among these components, (+) - catechin having a three- The effect is to keep the bad breath constantly.

Generally, the green tea extract is excellent in anti-inflammatory action and anti-bacterial action against various bacterium that inhibits swelling in the inflammation site, and also has excellent cell protection effect, so that the anti-aging effect of the skin is excellent, It is known to have an antimutagenic effect.

In addition, it inhibits angiotensin-converting enzyme that induces hypertension and relaxes platelets, thereby lowering blood pressure. In addition, it is known that it has an effect of inhibiting atherosclerosis by decreasing the concentration of blood cholesterol.

The myrrh is a fragrant, aromatic vegetable preservative that scarifies the tree trunks of the myrrh wood or spontaneously flows. Myrrh is mainly used for oral infection, has antimicrobial activity, and is also used as astringent, gustatory, and dry noodle.

The above-mentioned jade enzyme salt is used as a preventive ingredient for periodontal disease such as gingivitis and periodontitis.

The aloe vera gel is known to have antioxidant activity, antibacterial activity, antitumor activity, bactericidal action, anti-inflammatory action, and tissue-forming action.

The mastic is an evergreen shrub of lacquer tree and is 2 to 3 meters tall and grows very slowly after 40 to 50 years because of its very slow growth rate. And it produces gum from five-year-old trees. Mastic trees live for over 100 years, but begin to grow in about 70 years. Only Chia species grown exclusively in the southern part of the Greek island of Chios only produce pure and unique top quality gum mastic. It is listed on official drug lists in 25 countries around the world, including the British Pharmacopoeia (BP) and the European Pharmacopoeia (EP), and is widely used as a traditional medicinal product in many countries. As it has been studied scientifically in modern times, it has been used in various forms such as gum, toothpaste, spa, and cosmetics for stomach health related with Helicobacter. Mastic is effective for periodontal disease. Specifically, it inhibits development of six cariogenic bacteria and five periodontal pathogens, and is effective for periodontitis and gingivitis.

Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are intended to further illustrate the present invention, and the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Manufacturing example  One: Silane  Surface-coated with a compound Jade  Produce

500 g of a nephrite powder having an average particle size of 250 to 280 mesh was dispersed in water to prepare a slurry. Then, 40 g of a silane compound represented by the following formula (1) was added and reacted with stirring for 1 hour. After the reaction was completed, water was removed from the slurry to prepare a jade powder having a surface coated with a silane compound.

Manufacturing example  2: Preparation of jade enzyme salt

Ten kilograms of salted sun salt produced in Sinan County were baked in a cylindrical cauldron for 1.5 hours. The baked salt was cooled to room temperature. The cooled sun-dried salt was placed in a cylindrical mix chamber, and 500 ml of Sanayasen enzyme "white night" produced by Hwasun Dogok Gongjung Bongju Co., Ltd. was sprayed and dried. Next, 500 ml of "Oxantha" manufactured by Daeil Mining Co., Ltd. as a natural alkali reduced water having a pH of 7.5 to 8.5 was sprayed and dried. The dried sun-dried salt was aged for 3 months in a place free from direct sunlight and pulverized to prepare an enzyme enzyme salt.

Example  1: Preparation of dentifrice composition

As shown in the following Table 1, the dentifrice compositions of Examples 1 and 2 and the dentifrice composition of Comparative Example 1 according to the present invention were prepared by the following methods.

The binder was added to the wetting agent, diluted with alkaline reducing water, which is ground water produced in the jade mine area of pH 8.2, and mixed by a mixer. The abrasive, the active ingredient, the sweetener and the perfume were added thereto, Mixed with a surfactant, and mixed to prepare a dentifrice composition.

Example  One Example  2 Comparative Example  One Comparative Example  2 Surface-coated jade powder
(Preparation Example 1) 15 15 - 15 (uncoated jade powder) Silicon dioxide 10 10 25 10 Sorbitol aqueous solution (70%) 15 15 15 15 glycerin 10 10 10 10 Xanthan gum One One One One Carboxymethylcellulose sodium One One One One Sodium N-lauroyl glutamate 2 2 2 2 Steve Bioside One One One One Pepamine oil 1.5 One 1.5 1.5 Allantoin chlorohydroxy aluminum 2 2 2 2 Aminocaproic acid 1.5 1.5 1.5 1.5 Xylitol 1.5 1.5 1.5 1.5 Horsetail extract 2 1.5 2 2 Gosam extract 1.5 1.5 1.5 1.5 Grapefruit seed extract 1.5 One 1.5 1.5 Green tea extract 2 2 2 2 Myrrh 1.5 1.5 1.5 1.5 The enzyme enzyme salt of Preparation Example 2 2 2 2 (simple bamboo salt) 2 Aloe vera gel 2 1.5 2 2 Mastic 2 2 2 2 pH 8.2 Alkali-reduced water
(Using "OXANGA" manufactured by Daeil Mining Co., Ltd.) Balance Balance - Balance Purified water - - Balance -

Unit: weight%

Test Example  1: Performance evaluation of dentifrice composition

The present invention relates to a dentifrice composition comprising the dentifrice composition of Example 1, which contains alkaline-reduced water, silicon dioxide instead of nephrite powder, which contains bamboo salt instead of jade enzyme salt, The dentifrice composition of Comparative Example 1 containing purified water instead of alkaline reducing water was used for 30 days for a total of 30 adults and 15 men and women complaining symptoms of periodontal disease (5), toothache (5), bad breath (5) A blind test was conducted for 30 days. The subjects were given the scores according to the following criteria and their scores were averaged to evaluate the degree of improvement of the symptoms. The results are shown in Table 2 below.

<Evaluation Criteria>

Significant improvement: 5 points

Some improvement: 3 points

No improvement: 1 point

<Beauty>

○: Excellent

△: Normal

×: Not good

Example  One Comparative Example  One toothache 4.1 3.2 Periodontitis 4.3 3.0 Bad breath 4.0 3.2 Aesthetic ○ △

As shown in the above Table 2, the dentifrice composition of Example 1 of the present invention including the nephrite powder, the jade enzyme salt, and the pickled pH 8.2 alkali reduced water around the jade mine showed a very excellent improvement effect on toothache, periodontitis and bad breath . On the other hand, the dentifrice composition of Comparative Example 1 including silicon dioxide, bamboo salt, and purified water was found to be somewhat effective, but the dentifrice composition was clearly less effective than Example 1.

In addition, in the case of an aesthetics, the dentifrice composition of Example 1 of the present invention was found to be superior to the dentifrice composition of Comparative Example 1. [

Test Example  2: Comparative Evaluation of Stability of Dentifrice Composition

The dentifrice composition of Example 1 was stored at room temperature, and after 1, 2, 4, and 8 months, the properties of the dentifrice composition were observed, and the stability with time was evaluated according to the following criteria.

<Evaluation Criteria>

○: No phase separation phenomenon and no pellet sedimentation

△: There is no phase separation phenomenon and pellet sedimentation occurred.

X: Severe phase separation and pellet sedimentation occurred

Example  One Comparative Example  2 1 month storage ○ ○ Storage 2 months ○ △ Storage 4 months ○ △ Storage 8 months ○ △

As shown in Table 3, the dentifrice composition of Example 1 using the surface-coated nephrite powder with the silane compound represented by the formula (1) showed excellent stability of the dentifrice composition because phase separation and precipitation of the nephrite powder were not observed .

On the other hand, the composition of Comparative Example 2 using the uncoated nephrite powder was found after 2 months from the phenomenon that the nephrite was settled on the floor.

The test results show that the silane compound represented by the formula (1) contained in the dentifrice composition of the present invention functions to prevent the precipitation of the nephrite powder by allowing the nephrite powder to be stably and well dispersed.

Claims (7)

20 to 40% by weight of abrasive; 20 to 40% by weight of a wetting agent comprising an aqueous solution of sorbitol and glycerin; 1 to 10% by weight of a binder comprising xanthan gum and carboxymethylcellulose sodium; 0.1 to 5% by weight of a surfactant comprising sodium N-lauroyl glutamate; 0.1 to 2% by weight of a sweetener comprising stearic acid; 0.01 to 2% by weight of a perfume containing peppermint oil; 10 to 25% by weight of a pharmaceutical composition containing allantoin chlorohydroxy aluminum, aminocaproic acid, xylitol, horseradish extract, gossam extract, grapefruit seed extract, green tea extract, myrrh powder, aloe vera gel, and mastic; And a residual amount of natural alkali reduced water having a pH of 7.5 to 8.5,
The natural alkaline-reduced water having a pH of 7.5 to 8.5 is groundwater produced in the jade mine area,
Wherein the abrasive agent comprises 20 to 70% by weight of a jade powder and 30 to 80% by weight of silicon dioxide based on the total weight of the abrasive,
The jade powder has an average particle size of 100 to 400 mesh,
A dentifrice composition comprising a silane compound represented by the following formula (1):
[Chemical Formula 1]

delete delete delete The method according to claim 1,
The coating treatment with the silane compound
The dentifrice composition according to claim 1, wherein the dentifrice composition is prepared by preparing a slurry in water by adding the silicate compound to the slurry, stirring the slurry, and then removing water. The method according to claim 1,
And 0.1 to 3% by weight of a brightener containing titanium oxide. The method according to claim 1,
Further comprising at least one fluorine component selected from the group consisting of sodium fluoride, sodium monofluorophosphate, tin fluoride, and amine fluoride in a concentration of 500 to 1,500 ppm.