KR20210009110A - Antimicrobial toothpaste composition containing mastic and myrrh - Google Patents

Abstract

The present invention relates to an antibacterial toothpaste composition including mastic and myrrh, which is expected to mitigate and prevent periodontitis, gingivitis, and gum diseases, remove tartar and plaque, prevent tooth decay, refresh the mouth, and remove bad breath, and increases antibacterial activity against Helicobacter pylori and oral bacteria. According to the present invention, the antibacterial toothpaste composition comprises, with respect to 100 parts by weight of the total weight of the antibacterial toothpaste composition; 20 to 40 parts by weight of abrasive; 20 to 40 parts by weight of a wetting agent including an aqueous sorbitol solution and glycerin; 1 to 10 parts by weight of at least one binder selected from sodium carboxymethylcellulose, carbomer, carrageenan, xanthan gum, and alginates; 0.1 to 2 parts by weight of a sweetener including xylitol and stevioside; 0.01 to 2 parts by weight of a fragrance including menthol and peppermint oil; 10-25 parts by weight of a medicinal agent comprising at least one selected from a group consisting of sodium monofluorophosphate, allantoin chlorohydroxyaluminum, sodium fluoride, tocopherol acetate, a Houttuynia cordata extract, a Sophora flavescens extract, a grapefruit seed extract, a green tea extract, a Taraxacum platycarpum H. Dahlstedt extract, a Platycodon grandiflorum A. DC. concentrate, a Phellodendron amurense R. concentrate, potassium nitrate, tricalcium phosphate, strontium chloride, sodium pyrophosphate, potassium pyrophosphate, acid sodium pyrophosphate, citric acid, soda citrate, tranexamic acid, potassium phosphate, cetylpyridinium chloride, polyphosphate, metaphosphate, aloe vera gel, myrrh, jade enzyme salt, mastic, salt, and bamboo salt; and the remainder of natural alkali-reduced or purified water of pH 7.5 to 8.5.

Description

Antibacterial toothpaste composition containing mestic and myrrh {ANTIMICROBIAL TOOTHPASTE COMPOSITION CONTAINING MASTIC AND MYRRH}

The present invention relates to an antibacterial toothpaste composition containing mestic and myrrh, and more specifically, it is expected to improve and prevent periodontitis and gingivitis, improve and prevent gum disease, remove calculus plaque, prevent tooth decay, refresh the mouth, and remove bad breath, In particular, it relates to an antibacterial toothpaste composition containing mestic and myrrh that improves antibacterial activity against Helicobacter pylori and oral bacteria.

Toothpaste ingredients can be largely divided into abrasives, foaming agents, wetting agents, binders and flavoring agents. Abrasives remove foreign substances attached to the tooth surface to make the teeth shine, foaming agents make bubbles to easily remove dirty foreign substances, and wetting agents provide adequate humidity in the oral cavity. In addition, the binder allows the toothpaste to maintain a uniform and stable shape, and the flavoring agent allows brushing with a refreshing mood. And, in addition to toothpaste, fluorine compounds and allantoin to prevent gum disease are added to prevent tooth decay and to obtain teeth whitening effect.

Normally, the original function of toothpaste, that is, makes teeth white and strong, keeps the oral cavity clean and refreshes, removes bad breath and plaque (plaque), enhances the aesthetic effect, and improves cavities, gingivitis, periodontitis (alveolar fistula), periodontal disease Although it can prevent diseases, gum disease, and tartar deposition, fluorine is one of the halogen elements and is a pale green gas with a peculiar pungent odor, and its chemical reactivity is very strong, so it is used as a disinfectant or adhesive. This fluorine is used in the form of a colorless, irritating, toxic gaseous compound, especially added to toothpaste to strengthen the tooth surface and prevent decay of the cavities. The use of fluoride is suggested by the Ministry of Food and Drug Safety as a maximum of 1,000 ppm or less. This is because if the content of fluorine is high, the sterilizing effect against bacteria in the oral cavity increases, but the chemical reaction causes the teeth to become weak, sore, and damage the gums. Conversely, when the content is small, the antibacterial effect in the oral cavity is inferior.

In addition, conventional toothpaste uses strong abrasives to remove plaque, but it is not desirable to use toothpaste containing strong abrasives for the elderly or people with toothache symptoms, and prevents and causes various gum diseases and periodontal diseases. It is practically difficult to expect a reduction in disease and a healing effect.

Therefore, conventional toothpaste contains about 300 to 800 ppm of fluoride, but it is known to sterilize about 35% of harmful bacteria in the oral cavity. However, there is a problem in that such fluorine content cannot sterilize the pathogens of Helicobacter pylori in the oral cavity.

1. Korean Patent Registration No. 10-1854418 (Name of invention: toothpaste composition containing jade) 2. Republic of Korea Patent Registration No. 10-1956579 (Name of invention: toothpaste composition for relieving dentin hypersensitivity)

Accordingly, an object of the present invention is to be able to sterilize the Helicobacter pyroneous pathogen, which is known to cause most of the inflammation of the gums, as well as causing bad breath while bleeding. Provides an antibacterial toothpaste composition containing mestic and myrrh against Helicobacter pyroneous pathogens that can maintain the state and prevents gastritis or gastric ulcers as well as personal hygiene by preventing the entry of Helicobacter pyroneous pathogens into the stomach. It has its purpose.

An embodiment of the present invention for achieving the above object is 20 to 40 parts by weight of abrasive based on 100 parts by weight of the total composition of toothpaste; 20 to 40 parts by weight of a wetting agent including an aqueous sorbitol solution and glycerin; 1 to 10 parts by weight of one or more binders selected from sodium carboxymethylcellulose, carbomer, carrageenan, xanthan gum and alginates; 0.1 to 2 parts by weight of a sweetener including xylitol and sdevioside; 0.01 to 2 parts by weight of perfume including menthol and peppermint oil; Sodium monofluorophosphate, allantoin chlorohydroxyaluminum, sodium fluoride, tocopherol acetate, Eoseongcho extract, Gosam extract, grapefruit seed extract, green tea extract, Pogongyoung extract, grapefruit seed extract, Gilkyung concentrate, Hwangbaek concentrate, potassium nitrate, phosphate ginseng Calcium, strontium chloride, sodium pyrophosphate, potassium pyrophosphate, acid sodium pyrophosphate, citric acid, citrate soda, tranexamic acid, potassium phosphate, cetylpyridinium chloride, polyphosphate, metaphosphate, aloe vera gel, myrrh, oxenzyme salt , Mestic, 10 to 25 parts by weight of a medicinal agent containing at least one selected from the group consisting of salt and bamboo salt; And it provides an antibacterial toothpaste composition containing mestic and myrrh containing natural alkaline reduced water or purified water of pH 7.5 to 8.5 in the balance.

Meanwhile, 0.1 to 5 parts by weight of a surfactant may be further included in the toothpaste composition, and the surfactant may include at least one anionic surfactant selected from the group consisting of sodium lauryl sulfate and sodium alkyl sulfate; And polyoxyethylene, copolymer of polyoxypropylene, polyoxyethylene sorbitan fatty acid, alkanolamide fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene cast iron hydrogenated oil derivative, At least one nonionic surfactant selected from the group consisting of N-lauryl sarcosinate, sodium lauryl ether sulfate, polysorbate, decaglycerin monolaurenite, sorbitan monooleate, alkyl polyglucoside, and cocoamide DIA It provides an antibacterial toothpaste composition containing mestic and myrrh comprising at least one selected from the group consisting of.

On the other hand, the stevioside of the sweetener provides an antibacterial toothpaste composition containing mestic and myrrh obtained by treating a stevia extract with an alpha-clucosyl transferase.

On the other hand, it provides an antibacterial toothpaste composition containing mestic and myrrh further comprising lettuce powder, oat powder, turmeric powder, Eoseongcho powder, and sulfur powder in the medicinal agent.

On the other hand, cypress extract is further included in the medicinal agent, and the cypress extract is immersed in a mixed solvent of alcohol and purified water for 6-24 hours at room temperature, followed by 2 hours per day over 8-12 days. It provides an antibacterial toothpaste composition containing mestic and myrrh using essential oils obtained by stirring and filtering.

Since the composition of the antibacterial toothpaste containing mestic and myrrh of the present invention is formulated to sterilize the pathogen of Helicobacter pyrone, it can be sterilized even if the pathogen of Helicobacter pyrone flows from the top to the mouth due to reflux esophagitis, etc. In addition, the toothpaste composition prepared by adding mestic oil has antibacterial activity against Helicobacter pylori pathogens, so it can be usefully used as a new functional toothpaste composition having an effect of improving (or preventing) periodontal disease and removing bad breath.

In the following detailed description, an antibacterial toothpaste composition containing mestic and myrrh according to the present invention will be described in detail.

An embodiment of the present invention is 20 to 40 parts by weight of an abrasive based on 100 parts by weight of the total toothpaste composition; 20 to 40 parts by weight of a wetting agent including an aqueous sorbitol solution and glycerin; 1 to 10 parts by weight of one or more binders selected from sodium carboxymethylcellulose, carbomer, carrageenan, xanthan gum and alginates; 0.1 to 2 parts by weight of a sweetener including xylitol and sdevioside; 0.01 to 2 parts by weight of perfume including menthol and peppermint oil; Sodium monofluorophosphate, allantoin chlorohydroxyaluminum, sodium fluoride, tocopherol acetate, Eoseongcho extract, Gosam extract, grapefruit seed extract, green tea extract, Pogongyoung extract, grapefruit seed extract, Gilkyung concentrate, Hwangbaek concentrate, potassium nitrate, phosphate ginseng Calcium, strontium chloride, sodium pyrophosphate, potassium pyrophosphate, acid sodium pyrophosphate, citric acid, citrate soda, tranexamic acid, potassium phosphate, cetylpyridinium chloride, polyphosphate, metaphosphate, aloe vera gel, myrrh, oxenzyme salt , Mestic, 10 to 25 parts by weight of a medicinal agent containing at least one selected from the group consisting of salt and bamboo salt; And it provides an antibacterial toothpaste composition containing mestic and myrrh containing natural alkaline reduced water or purified water of pH 7.5 to 8.5 in the balance.

The abrasive may be used only with silicon dioxide, or may include 20 to 70 parts by weight of fine grain powder and 30 to 80 parts by weight of silicon dioxide based on the total weight of the abrasive.

In addition, the toothpaste composition of the present invention may further include 0.1 to 3 parts by weight of a whitening agent containing titanium oxide.

In addition, the antibacterial toothpaste composition containing mestic and myrrh of the present invention may further contain a fluorine component, and sodium fluoride, sodium fluoride phosphate, tin fluoride, amine fluoride, etc. may be used as the fluorine component. They may be used alone or in combination of two or more in a concentration of 500 to 1,500 ppm.

In addition to the above-described components, additives generally used in the toothpaste composition may be used without limitation within a range not contrary to the object of the present invention. For example, potassium nitrate, tricalcium phosphate (relieving stiffness), sodium lauryl sulfate (foaming agent), and the like may additionally be used.

The antibacterial toothpaste composition containing the mestic and myrrh of the present invention provides a toothpaste composition that is more excellent in suppressing ache by adjusting the pH to 7.0-8.5.

Hereinafter, the medicinal ingredients of the antibacterial toothpaste composition containing mestic and myrrh will be described in detail.

In the present invention, the abrasive may use only silicon dioxide, or may include 20 to 70 parts by weight of fine grain powder and 30 to 80 parts by weight of silicon dioxide based on the total weight of the abrasive. The composition of the abrasive should be adjusted in consideration of the polishing power, efficacy and effect of the tooth. In the toothpaste composition of the present invention, the abrasive is contained in an amount of 20 to 40 parts by weight.

In the present invention, the humectant is used to prevent the evaporation of moisture when the toothpaste is exposed to the air to prevent the ointment-like toothpaste from drying and solidifying, and includes an aqueous solution of sorbitol and glycerin, and is included in an amount of 20 to 40 parts by weight.

In the present invention, the binder is formulated for the purpose of maintaining the ointment phase by combining a liquid component of toothpaste and a solid component such as an abrasive, preventing separation of the liquid component and forming a viscosity suitable for use. In the present invention, the binder includes at least one selected from sodium carboxymethylcellulose, carbomer, carrageenan, xanthan gum, and alginates, and is included in an amount of 1 to 10 parts by weight.

In addition, flavoring and sweetening agents are used to enhance the feeling of mouthwash, and flavorings including menthol and peppermint oil, and sweetening agents including xylitol and sdebioside are used. The flavoring and sweetening agent are included in 0.01 to 2 parts by weight and 0.1 to 2 parts by weight, respectively.

The xylitol has a unique pentose structure that cannot be decomposed by tooth decay bacteria, and thus has a function of reducing the occurrence of tooth decay. Specifically, for example, Mutans bacteria, a representative tooth decay-causing bacteria, mistake xylitol as sugar and eat it, but xylitol is not digested by caries, so it cannot produce acid, which is the cause of tooth damage. In the process of continuing to eat xylitol, the activity becomes weaker as all energy is consumed, inhibiting the growth of caries bacteria, reducing the formation of plaque, a bacterial film on the tooth surface, and preventing the production of acid, thereby reducing the occurrence of caries.

The present invention also provides sodium monofluorophosphate, allantoin chlorohydroxyaluminum, sodium fluoride, tocopherol acetate, Eoseongcho extract, Gosam extract, grapefruit seed extract, green tea extract, pogongyeong extract, grapefruit seed extract, Gilkyung concentrate, Hwangbaek concentrate gas, Potassium nitrate, tricalcium phosphate, strontium chloride, sodium pyrophosphate, potassium pyrophosphate, acid sodium pyrophosphate, citric acid, citrate soda, tranexamic acid, potassium phosphate, cetylpyridinium chloride, polyphosphate, metaphosphate, aloe vera gel, It includes 10 to 25 parts by weight of a medicinal agent containing at least one selected from the group consisting of myrrh, oxenzyme salt, mestic, salt, and bamboo salt.

Here, the Eoseongcho extract is effective in removing inflammation and acts to increase the effect of removing bacteria that cause gum disease.

The gosam extract is added to have an anti-inflammatory function, such as bamboo salt, and gosam has an ingredient called matrin to activate the peristaltic movement of the intestine, and is particularly used for eczema or skin purulent, and pain and scabies caused by warts, boils, scabies, etc. It is used to relieve itching.

The main antibacterial substances in the grapefruit seed extract are ingredients called naringin and citral. Naringin is a component called flavonoid known as vitamin P. This substance is mainly found in the seeds and skins of ripe grapefruits. Narinjin has a bitter taste, and its molecular formula is C27H32014·2H2O.

The green tea extract mainly contains components such as caffeine, organic acids, amino acids, (+)-catechin, and sugars, and among these ingredients, (+)-catechin, which has a three-dimensional structure of a porylphenol derivative, is enclosed. It continuously suppresses bad breath by action.

In general, green tea extract has excellent anti-inflammatory and antimicrobial effects against various bacteria to suppress swelling in the inflamed area, and has excellent anti-aging effects on the skin, and also acts on animal cancer cells to inhibit cancer. It is known to have an antimutagenic effect.

In addition, it is known to have an effect of lowering blood pressure by inhibiting angiotensin transfer enzyme that induces high blood pressure and relaxing platelets. In addition, it is known to have an effect of inhibiting arteriosclerosis by reducing the concentration of cholesterol in the blood.

The myrrh is a scented wood dust that has been hardened by hurting or flowing down on a tree trunk of a myrrh tree, and as a vegetable preservative, myrrh is mainly used for oral infections, has antibacterial activity, and is also used as an astringent, antifoam, and dry stomach.

More specifically, myrrh is known as a substance having a strong analgesic effect on its own ingredients. The main components are Furanoeudesman-1, 3-diene, Lindestrenee, Furanodiene, 2-methoxyfuranodiene, 2-acetoxyfuranodiene, and Insofuranogermancrene. In general, most of myrrh consists of sesquiterpene.

On the other hand, myrrh resin, despite its useful antibacterial activity, has been commercialized in a limited way because it is not easy to use because it is not dissolved or dispersed in water. It is known as'guggulsterone', but if you look at the exterior of this product, it is a solid mass that is 1~3cm in diameter or more).

In addition, the myrrh used in the present invention uses a conventional myrrh resin oil, and a conventional myrrh resin oil causes precipitation and color change over time, but the myrrh resin oil prepared by the method of the present invention has a form It can be easily used for food, soft capsules, toothpaste, cosmetics, and other products as it is highly safe due to little change or precipitation. In particular, myrrh resin is known to have a strong analgesic effect, immunity strengthening effect, antibacterial effect against various bacteria including bacteria that cause cavities and periodontitis. When using myrrh resin oil, a composition for the treatment and prevention of various diseases, and for skin care. It is easy to apply to compositions and functional foods.

The method of manufacturing the myrrh resin oil first removes foreign substances attached to the myrrh resin and performs impurities removal and washing to wash the myrrh resin, and then the myrrh resin after the impurity removal and washing is naturally dried and naturally dried. Then, the myrrh resin is cooled to -15 to -20°C, and the cooled myrrh resin is processed into powdered myrrh resin by a commonly used pulverizing method, followed by drying and pulverizing steps, which are obtained in the drying and pulverizing steps. The myrrh resin powder is mixed with a compound extract or any one selected from enzymes or solvents to perform the aging step of aging the myrrh resin powder, drying the aged myrrh resin powder through the above aging step, and pulverizing the dried myrrh resin powder again. After the aging, drying, and pulverization, the myrrh resin powder is mixed with the liquid oil, and the myrrh resin powder and the oil that have gone through the oil mixing step are mixed evenly to make the myrrh into oil. You will get an oil.

Here, when the aged myrrh resin is dried, it is solidified into a lump-shaped myrrh resin, and the dried lump-shaped myrrh resin is pulverized using a general grinding method. It is preferable to pulverize while maintaining the size of the particles to be pulverized about 200-300 mesh.

Drying in the step of pulverizing again may be selected from natural drying or artificial drying. In order to control the drying time, artificial drying is performed, otherwise, it is preferable to pulverize after natural drying.

In addition, the method of mixing the aged pulverized particle myrrh resin powder with oil is mixed by adding an appropriate amount of aged myrrh resin powder to the oil and stirring by heating. Preferably, when the temperature of the oil reaches a temperature of 50° C., the obtained aged myrrh resin powder is added in small portions. At this time, it is preferable to add the myrrhic resin powder in a ratio of 1:50 or 1:80 to the mass of the oil and maintain the stirring speed of about 600 to 700 rpm. In addition, the oil to be added is preferably mestic oil or any one selected from rapeseed oil, mono- or di-glyceride of oleic acid, isopropyl myristate, isopropyl palmitate, ethyl linoleate, and ethyl oleate. Do.

And, the myrrh resin oil prepared by the above-described manufacturing method is used instead of or together with the myrrh in a medicinal solution, and the myrrh refers to a conventional myrrh resin oil or myrrh powder, which is the same as myrrh to be described later. Is applied.

In addition, 0.01 to 20 parts by weight of myrrh resin oil prepared by the above-described manufacturing method may be included and used with respect to the total weight of the medicinal solvent.

In addition, in order to use the myrrh resin as an extract containing the active ingredients of the myrrh resin, not as a powder, the myrrh resin extract or fermented myrrh resin obtained through the following process is included in the toothpaste composition.

The myrrh resin was immersed in a solution of sodium hypochlorite having a pH of 5.0 to 6.0 for 1 to 5 minutes, followed by washing and natural drying, followed by pulverizing the dried myrrh resin and water as a solvent. The mixture is mixed at a weight ratio of 1:0.3 to 0.6, and then hot water extraction or ultrasonic extraction is performed.At this time, after adding water to the myrrh resin powder powder, hot water extraction at a temperature of 80 to 100°C for 6 to 12 hours, or After water is added to the myrrh resin powder powder, pretreatment is performed for 20 to 30 minutes under conditions of 100 to 150 kHz using an ultrasonic extractor, and hot water is extracted again for 6 to 12 hours at a temperature of 50 to 60°C. It is prepared, and may be used by including the myrrh resin extract in a medicinal solution instead of or together with myrrh or 0.01 to 10 parts by weight of the myrrh resin extract based on the total weight of the medicinal agent.

By immersing the myrrh resin mass in the sodium hypochlorite solution within the above-described concentration and time, it is possible to more effectively remove general bacteria and E. coli that may exist in the myrrh resin.

In addition, the sodium hypochlorite solution may be a weakly acidic sodium hypochlorite solution having a pH of 5.0 to 6.0, wherein the weakly acidic sodium hypochlorite solution contains less than 2% hypochlorous acid ions (OCl-) and 98 to 100% hypochlorous acid. If the pH of the sodium hypochlorite solution is higher than 6, the generation of hypochlorite ions increases and the sterilization power decreases, and a sodium hypochlorite solution with a pH of less than 5.0 is effective. Since the chlorine component contains molecular chlorine, it has a chlorine irritant odor and metal corrosion, and the effective chlorine component, hypochlorous acid (HOCl), becomes chlorine and volatilizes during storage due to its low pH, so the effective chlorine concentration of hypochlorous acid water is There is a drawback that storage stability is lowered due to the deterioration.

Therefore, it is preferable to use a weakly acidic sodium hypochlorite solution as the myrrhic resin of the present invention.

In addition, by obtaining the myrrh resin extract by the hot water extraction or ultrasonic extraction, there is an advantage in that the active ingredient contained in the myrrh resin can be almost extracted.

In addition, 0.1 to 1 parts by weight of salt and lactic acid bacteria are added to the myrrh resin extract to the myrrh resin extract obtained through the extraction step of the myrrh resin extract, followed by primary fermentation, and then the extract obtained by pressure distillation is further aged and fermented. Going through the acquisition stage of fermented myrrh resin,

Adding 0.1 to 0.5 parts by weight of water-soluble propolis and lactic acid bacteria to the first fermented myrrh resin and obtaining a second fermented myrrh resin for secondary fermentation,

After adding 0.5 to 3 parts by weight of minerals and yeast to the second fermented myrrh resin and fermenting the third fermented myrrh resin,

After inoculating actinomycetes and Bacillus bacteria in the third fermented myrrh resin, mixing 0.5 to 3 parts by weight of green tea leaf powder with respect to the third fermented myrrh resin, followed by the fourth fermentation step of obtaining a fourth myrrh resin fermentation, and,

Prepared by a method comprising the step of obtaining a 5 th myrrh resin fermentation by adding 0.05 to 2 parts by weight of glycerin, chlorella and mestic oil to the 4 th myrrh resin fermentation product, dispersing at high speed, homogenizing, and then fermenting the 5 th myrrh resin The myrrh resin fermentation broth is used, and the myrrh resin fermentation broth may be used by including the myrrh resin fermentation broth in a medicinal solution instead of or with the myrrh or the myrrh resin fermentation broth, and the above-described myrrh resin extract or the myrrh resin extract and myrrh may be used together. In addition, 0.01 to 10 parts by weight of a myrrh resin fermentation broth based on the total weight of the medicinal solvent may be used.

In the step of obtaining the first and second myrrh resin fermentations, the lactic acid bacteria are Lactobacillus reuteri, Lactobacillus casei, Lactobacillus plantarum, and Lactobacillus acidophilus ( Lactobacillus acidophillus), Lactobacillus lactis, Lactobacillus helveticus, Lactobacillus rhamnosus, Lactobacillus bulgaricus or a combination thereof.

In the step of obtaining the tertiary myrrh resin fermentation, the yeast fungus includes at least one selected from Saccharomyces cerevisiae and Zygosaccharomyces major.

And, in the step of obtaining the third myrrh resin fermentation, actinomycetes are Streptomyces griseus, Streptomyces aureus

(Streptomyces aureus), Streptomyces avidoflavus (Streptomycesabisoflavus), or a combination thereof, and the Bacillus subtilis, Bacillus subtilis, Bacillus subtilis, Bacillus mega Terium (Bacillus megaterium), Bacillus licheniformis, Bacillus natto, Bacillus pumilus, or a combination thereof are used.

The actinomycetes are excellent in antibiotic production and have a great effect in inhibiting pathogens, and they are decomposed in the process of inoculating and fermenting the Bacillus strains and converted into smaller, low-molecular substances, thereby being released in a state that is easy to bind with other substances. When used as a medicinal material, the preservability of the produced by-products can be further improved.

And, since glycerin used in the step of obtaining the 5th myrrh resin fermentation product is easily oxidized and deteriorated when provided as a toothpaste composition containing the myrrhic resin fermentation broth, vegetable glycerin is mixed with the 4th myrrh resin fermentation product. As a means to increase the stability so as not to deteriorate for a long period of time after, the fermentation process is performed by inoculating the above-described myrrh resin fermentation broth with harmless plant seeds, thereby enhancing durability.

The chlorella is a very small single-celled organism, a kind of natural freshwater green algae, has active photosynthesis and has excellent cell division ability, contains a large amount of chlorophyll, essential amino acids, various vitamins and minerals, helps cell metabolism, and helps cell resurrection. As it is used by mixing with fermented tea myrrh resin, it is recognized for its resistance to bacteria and viruses, and has the effect of promoting fermentation of lactic acid bacteria and proteolytic bacteria, detoxifying heavy metals, and purifying contaminated water.

The mestic oil is used to have the emulsion stability of the active ingredient and myrrh resin fermentation broth contained in the mestic oil.

In addition, the oxenzyme salt is used as a component for preventing periodontal diseases such as gingivitis and periodontitis.

The aloe vera gel is known to have antioxidant activity, antibacterial activity, antitumor activity, bactericidal activity, anti-inflammatory activity, and tissue formation activity.

The mestic is an evergreen shrub of the sumacaceae family, its height is 2-3 meters, and its growth rate is very slow, so that it will not grow until 40-50 years have passed. And from a 5-year-old tree, gum is produced. Mestic trees live for over 100 years, but begin to age after 70 years. Only the Chia species, grown exclusively in the southern part of the Greek island of Chios, produce pure, unique, premium gum mestic. It is listed on the official drug list of 25 countries around the world, including the British Pharmacopoeia (BP) and European Pharmacopoeia (EP), and is widely used as a traditional medicine in many countries. In modern times, with scientific research, the utilization of Helicobacter is increasing in various forms such as gum, toothpaste, spa, and cosmetics for gastrointestinal health. Mestic has excellent efficacy against periodontal disease, specifically inhibits the development of 6 types of caries causative bacteria and 5 types of periodontal pathogens, and is effective against periodontitis and gingivitis.

In addition, although mestic oil can be used alone in the toothpaste composition of the present invention, a surfactant is included as a component that supplements the solubilization power of ethanol in consideration of solubility, and such surfactants include polysorbate, polyoxyl hydrogenated castor. Free, sodium alkyl sulfate, sodium N-acyl sarcosinate, fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene high alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polypropylene fatty acid ester, etc. These may be used alone or in combination.

However, when considering the solubilization stability and taste of mestic oil, polysorbate, polyoxyl hydrogenated castor oil, or a mixture thereof is preferable.When only one emulsifier is used among polysorbate and polyoxyl hydrogenated castor oil, In some cases the stick oil is not completely solubilized, so it is most preferable to use a mixture of these.

The content of such polysorbate, polyoxyl hydrogenated castor oil or a mixture thereof is preferably 0.1 to 10 parts by weight, and more preferably 0.5 to 4 parts by weight. When the surfactant is contained in less than 0.1 parts by weight, it is difficult for mestic oil to be solubilized when mixed with water, and when it is contained in more than 10 parts by weight, the soap taste becomes too strong, leading to a problem of poor marketability. When comprehensively considering taste and solubility, the total content of polysorbate and polyoxyl hydrogenated castor oil is preferably 0.5 to 4 parts by weight, and the content of each of polysorbate and polyoxyl hydrogenated castor oil is 0.1 to 2 parts by weight and It is more preferably 0.5 to 2 parts by weight.

In addition, the surfactant, which is a foaming agent further included in the antibacterial toothpaste composition containing the mestic and myrrh of the present invention, supplements the cleaning action of the abrasive and generates air bubbles to increase the brushing feel.

In the present invention, the foaming agent may further include 0.1 to 5 parts by weight of a surfactant in the toothpaste composition, and the surfactant is at least one anionic surfactant selected from the group consisting of sodium lauryl sulfate and sodium alkyl sulfate; And polyoxyethylene, copolymer of polyoxypropylene, polyoxyethylene sorbitan fatty acid, alkanolamide fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene cast iron hydrogenated oil derivative, At least one nonionic surfactant selected from the group consisting of N-lauryl sarcosinate, sodium lauryl ether sulfate, polysorbate, decaglycerin monolaurenite, sorbitan monooleate, alkyl polyglucoside, and cocoamide DIA It provides a toothpaste composition comprising at least one selected from the group consisting of.

In addition, the stevioside of the sweetener provides a toothpaste composition obtained by treating the stevia extract with alpha-clucosyl transferase.

Enzymatically modified stevia is alpha-glucosyl stevioside, the main component of gami, by treating the stevia extract with alpha-clucosyl transferase. In addition to its sweetening effect, it reduces the formation of flags, a bacterial film on the tooth surface, and prevents caries. It works.

In addition, it provides an antibacterial toothpaste composition containing mestic and myrrh further comprising lettuce powder, oat powder, turmeric powder, Eoseongcho powder and sulfur powder in the medicinal agent.

The lettuce and oat powder contain a large amount of fiber, so the fibrous component plays a role in removing the plug by wiping away the fine food residues of the teeth, and the kaolin clay is a naturally produced hydrous aluminum silicate powder. It is used as a main raw material for ceramics or as an abrasive in the present invention, and the turmeric is said to have medicinal effects on anti-inflammatory and anti-inflammatory properties in the metabolism of oriental medicine, and Eoseongcho has excellent anti-inflammatory and purifying effects, and natural sulfur plays a role in detoxifying and resolving chemical poisons. Do it.

In addition, cypress extract is further included in the medicinal agent, and the cypress extract is immersed in a mixed solvent of alcoholic alcohol and purified water for 6-24 hours at room temperature, followed by 2 hours per day over 8-12 days. It provides an antibacterial toothpaste composition containing mestic and myrrh using essential oils obtained by stirring and filtering.

Cypress (hinoki cypress, Chamaecyparis obtusa (Siebold & Zucc.) Endl.), which is a material of the cypress extract, is a giant evergreen tree belonging to the genus Cypress family cypress, and contains about 1% of essential oil in the leaves and wood of cypress.

And, cypress essential oil has been used as a fragrance, cosmetics, perfume, soap, detergent, spices, etc. from ancient times, and in recent years, antibacterial, anti-inflammatory, antifungal, antiviral and anticancer effects of essential oils have been reported. In particular, it has been reported to reduce the amount of plaque and reduce pathogenicity by inhibiting gram-negative bacteria.

Thus, the cypress extract and essential oil included in the present invention are effective in improving allergies and skin diseases, and in particular, strong antibacterial effect against oral bacteria that are the cause of tooth decay, gum disease, periodontitis, oral inflammation, bad breath, and a deodorant effect, In addition, it exhibits a feeling of refreshment, sedation, stress relief, and depression reduction effects due to the unique scent of cypress.

The manufacturing process of the cypress extract is to remove contaminants by immersing the cypress leaves in water, and then repeat the process of washing for 30 minutes using an ultrasonic cleaner 10 times to remove contaminants from the cypress leaves, and then the easy extraction of cypress oil. To increase the pulverizer, pulverize at 15000 RPM for 5 minutes, and then set the volume ratio of alcoholic alcohol: purified water: cypress = 6: 3: 6 so that the mixed solvent in the large-capacity extraction tank is well absorbed by the crushed cypress leaves at 21℃. After leaving for 12 hours, agitating every 2 hours for a total of 10 days, after going through the first filtration process, a second filtration step using a 45μm diameter wire mesh, and a third filtration step using a 20μm diameter filter paper. The final cypress leaf flavoring solution (essential oil) is extracted.

As described above, the present invention has been described in detail, but this is only to illustrate the present invention, not to limit the present invention, and various changes and modifications are possible for those skilled in the art without departing from the gist and scope of the present invention. And this is also within the scope of the present invention.

Claims (6)

20 to 40 parts by weight of abrasive based on 100 parts by weight of the total composition of toothpaste; 20 to 40 parts by weight of a wetting agent including an aqueous sorbitol solution and glycerin; 1 to 10 parts by weight of one or more binders selected from sodium carboxymethylcellulose, carbomer, carrageenan, xanthan gum and alginates; 0.1 to 2 parts by weight of a sweetener including xylitol and sdevioside; 0.01 to 2 parts by weight of perfume including menthol and peppermint oil; Sodium monofluorophosphate, allantoin chlorohydroxyaluminum, sodium fluoride, tocopherol acetate, Eoseongcho extract, Gosam extract, grapefruit seed extract, green tea extract, Pogongyoung extract, grapefruit seed extract, Gilkyung concentrate, Hwangbaek concentrate, potassium nitrate, phosphate ginseng Calcium, strontium chloride, sodium pyrophosphate, potassium pyrophosphate, acid sodium pyrophosphate, citric acid, citrate soda, tranexamic acid, potassium phosphate, cetylpyridinium chloride, polyphosphate, metaphosphate, aloe vera gel, myrrh, oxenzyme salt , Mestic, 10 to 25 parts by weight of a medicinal agent containing at least one selected from the group consisting of salt and bamboo salt; And antibacterial toothpaste composition containing mestic and myrrh, characterized in that it comprises a balance of pH 7.5 to 8.5 natural alkaline reduced water or purified water. The method of claim 1,
Antibacterial toothpaste composition containing mestic and myrrh, characterized in that a mixture of 20 to 70 parts by weight of rice bran powder and 30 to 80 parts by weight of silicon dioxide based on the total weight of the abrasive. The method of claim 1,
0.1 to 5 parts by weight of a surfactant may be further included in the toothpaste composition, and the surfactant is at least one anionic surfactant selected from the group consisting of sodium lauryl sulfate and sodium alkyl sulfate; And polyoxyethylene, copolymer of polyoxypropylene, polyoxyethylene sorbitan fatty acid, alkanolamide fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene cast iron hydrogenated oil derivative, At least one nonionic surfactant selected from the group consisting of N-lauryl sarcosinate, sodium lauryl ether sulfate, polysorbate, decaglycerin monolaurenite, sorbitan monooleate, alkyl polyglucoside, and cocoamide DIA Antibacterial toothpaste composition comprising mestic and myrrh, characterized in that it comprises at least one selected from the group consisting of. The method of claim 1,
Stevioside of the sweetener is an antibacterial toothpaste composition containing mestic and myrrh, characterized in that obtained by treating the stevia extract with an alpha-clucosyl transferase. The method of claim 1,
Myrrh resin powder powder obtained by immersing the solid myrrh resin in the medicinal solvent in a solution of sodium hypochlorite having a pH of 5.0 to 6.0 for 1 to 5 minutes, followed by washing and natural drying, and then pulverizing the dried myrrh resin And water as a solvent and mixed at a weight ratio of 1:0.3~0.6, followed by hot water extraction or ultrasonic extraction.At this time, after adding water to the myrrh resin powder, 6~12 at a temperature of 80~100℃ After time hot water extraction or adding water to myrrh resin powder powder, pre-treat for 20-30 minutes under conditions of about 100-150 kHz using an ultrasonic extractor, and then hot water extraction for 6-12 hours at a temperature of 50-60℃ Antibacterial toothpaste composition containing mestic and myrrh, characterized in that it further comprises a myrrh resin extract. The method of claim 5,
The first myrrh resin in which 0.1 to 1 parts by weight of salt and lactic acid bacteria are added to the myrrh resin extract and first fermented, and then the extract obtained by pressure distillation is further aged and fermented. Going through the stage of obtaining fermented products,
Adding 0.1 to 0.5 parts by weight of water-soluble propolis and lactic acid bacteria to the first fermented myrrh resin and obtaining a second fermented myrrh resin for secondary fermentation,
After adding 0.5 to 3 parts by weight of minerals and yeast to the second fermented myrrh resin and fermenting the third fermented myrrh resin,
After inoculating actinomycetes and Bacillus bacillus into the third fermented myrrh resin, mixing 0.5 to 3 parts by weight of green tea leaf powder with respect to the fermented product of the second myrrh resin and performing the fourth fermentation step of obtaining a fermented product of the fourth myrrh resin, and,
Prepared by a method comprising the step of obtaining a 5 th myrrh resin fermentation by adding 0.05 to 2 parts by weight of glycerin, chlorella and mestic oil to the 4 th myrrh resin fermentation product, dispersing at high speed, homogenizing, and then fermenting the 5 th myrrh resin Antibacterial toothpaste composition containing mestic and myrrh, characterized in that it further comprises a fermented myrrh resin fermentation broth.