CN108969425B - Grifola frondosa polysaccharide toothpaste - Google Patents
Grifola frondosa polysaccharide toothpaste Download PDFInfo
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- CN108969425B CN108969425B CN201811159118.3A CN201811159118A CN108969425B CN 108969425 B CN108969425 B CN 108969425B CN 201811159118 A CN201811159118 A CN 201811159118A CN 108969425 B CN108969425 B CN 108969425B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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Abstract
Grifola frondosa polysaccharide toothpaste belongs to the technical field of daily necessities. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 62-72 parts of sorbitol, 15-20 parts of hydrated silica, 2-3 parts of sodium lauryl sulfate, 3-8 parts of propylene glycol, 0.2-0.5 part of grifola frondosa extract, 0.1-0.3 part of aloe vera extract, 0.4-1.0 part of carboxymethyl cellulose gum, 1-2 parts of mint extract, 0.5-1.0 part of xanthan gum, 0.1-0.3 part of saccharin sodium, 0.1-0.3 part of sodium benzoate and 10-25 parts of ultrapure water. The grifola frondosa polysaccharide toothpaste is reasonable in design, has the effects of preventing tooth stain accumulation, cleaning oral cavity, keeping gum health, relieving oral odor, refreshing breath and the like, can relieve various oral problems, keeps refreshing taste and provides multiple protection.
Description
Technical Field
The invention belongs to the technical field of daily necessities, and particularly relates to grifola frondosa polysaccharide toothpaste.
Background
At present, the common oral care products mainly comprise toothpaste, mouthwash and the like, and the basic functions of the oral care products are to clean crowns, protect gingiva and reduce the concentration of oral bacteria so as to prevent oral diseases. With the improvement of living standard, the health care consciousness is enhanced. People put forward more requirements on oral care products, so that the oral care products which are mainstream in the market are added with functional components for preventing and treating various oral diseases, but most of the oral care products are compounds synthesized by a chemical method.
With the continuous development of environmental protection and health consciousness. Consumers are concerned more and more about the safety of toothpaste, and the toothpaste has the two characteristics of natural property and safety. The toothpaste added with the Chinese herbal medicine active ingredients capable of effectively preventing and treating oral diseases is favored by consumers due to the characteristics of environmental protection, nature, safety and the like, and the market demand for the toothpaste is continuously increased.
Grifola frondosa, also known as chestnut mushroom and Polyporus frondosus, is called as "Maitake mushroom" in Japan, belongs to Basidiomycetes in taxonomic order, Polyporaceae, and is a rare edible fungus used as both medicine and food. The product has delicious taste and rich nutrition, contains a plurality of active substances, and the grifola frondosa polysaccharide is the most main active component.
At present, no toothpaste containing the polysaccharide component of the grifola frondosa is reported.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to design and provide a technical scheme of grifola frondosa polysaccharide toothpaste.
The grifola frondosa polysaccharide toothpaste is characterized by being prepared from the following raw materials in parts by weight:
62-72 parts of sorbitol, 15-20 parts of hydrated silica, 2-3 parts of sodium lauryl sulfate, 3-8 parts of propylene glycol, 0.2-0.5 part of grifola frondosa extract, 0.1-0.3 part of aloe vera extract, 0.4-1.0 part of carboxymethyl cellulose gum, 1-2 parts of mint extract, 0.5-1.0 part of xanthan gum, 0.1-0.3 part of saccharin sodium, 0.1-0.3 part of sodium benzoate and 10-25 parts of ultrapure water.
The grifola frondosa polysaccharide toothpaste is characterized by being prepared from the following raw materials in parts by weight:
65-70 parts of sorbitol, 16-18 parts of hydrated silica, 2.2-2.8 parts of sodium lauryl sulfate, 4-7 parts of propylene glycol, 0.3-0.4 part of grifola frondosa extract, 0.1-0.3 part of aloe vera extract, 0.5-0.8 part of carboxymethyl cellulose gum, 1.2-1.8 parts of mint extract, 0.6-0.8 part of xanthan gum, 0.1-0.3 part of saccharin sodium, 0.1-0.3 part of sodium benzoate and 12-20 parts of ultrapure water.
The grifola frondosa polysaccharide toothpaste is characterized by being prepared from the following raw materials in parts by weight:
68 parts of sorbitol, 18 parts of hydrated silica, 2.5 parts of sodium lauryl sulfate, 5 parts of propylene glycol, 0.3 part of grifola frondosa extract, 0.2 part of aloe vera extract, 0.5 part of carboxymethyl cellulose gum, 1.2 parts of mint extract, 0.6 part of xanthan gum, 0.1 part of saccharin sodium, 0.2 part of sodium benzoate and 15 parts of ultrapure water.
The grifola frondosa polysaccharide toothpaste is characterized in that the grifola frondosa polysaccharide toothpaste is obtained by the following steps: taking a dry product of the grifola frondosa, crushing the dry product into coarse powder, adding 20 times of water, carrying out reflux extraction at the temperature of 90-100 ℃ for 2-4 hours, filtering by using a plate-and-frame filter press, collecting filter residues, adding 7 times of water for secondary extraction, filtering, combining filtrates, and concentrating under reduced pressure at the temperature of 75 ℃ until the relative density is 1.15-1.20 to obtain the grifola frondosa extract.
The preparation method of the grifola frondosa polysaccharide toothpaste comprises the following steps: pre-dispersing xanthan gum, carboxymethyl cellulose gum and propylene glycol according to the formula ratio; then adding sorbitol, Grifola frondosa extract, Aloe extract, herba Menthae extract, saccharin sodium, sodium lauryl sulfate, and sodium benzoate in formula amount, and dissolving with ultrapure water in a premixing pot; adding the hydrated silica with the formula amount into a paste preparation pot, kneading, homogenizing and degassing to obtain paste; and (4) beating a small amount of paste for semi-finished product detection, and after the paste is qualified, putting the paste into a paste storage pot for aging to obtain the grifola frondosa polysaccharide toothpaste.
The grifola frondosa polysaccharide toothpaste is reasonable in design, has the effects of preventing tooth stain accumulation, cleaning oral cavity, keeping gum health, relieving oral odor, refreshing breath and the like, can relieve various oral problems, keeps refreshing taste and provides multiple protection.
Detailed Description
The following examples are provided to illustrate and explain the present invention, and it should be understood that the examples described herein are only for the purpose of illustration and explanation and are not intended to limit the present invention.
The grifola frondosa polysaccharide toothpaste comprises, by weight, 62-72 parts of sorbitol, 15-20 parts of hydrated silica, 2-3 parts of sodium lauryl sulfate, 3-8 parts of propylene glycol, 0.2-0.5 part of grifola frondosa extract, 0.1-0.3 part of aloe vera extract, 0.4-1.0 part of carboxymethyl cellulose gum, 1-2 parts of mint extract, 0.5-1.0 part of xanthan gum, 0.1-0.3 part of saccharin sodium, 0.1-0.3 part of sodium benzoate and 10-25 parts of ultrapure water.
The grifola frondosa polysaccharide toothpaste is prepared by the following steps: pre-dispersing xanthan gum, carboxymethyl cellulose gum and propylene glycol according to the formula ratio; then adding sorbitol, Grifola frondosa extract, Aloe extract, herba Menthae extract, saccharin sodium, sodium lauryl sulfate, and sodium benzoate in formula amount, and dissolving with ultrapure water in a premixing pot; adding the hydrated silica with the formula amount into a paste preparation pot, kneading, homogenizing and degassing to obtain paste; and (4) beating a small amount of paste for semi-finished product detection, and after the paste is qualified, putting the paste into a paste storage pot for aging to obtain the grifola frondosa polysaccharide toothpaste.
Example 1:
the common toothpaste is prepared from the following raw materials in parts by weight: 65 parts of sorbitol, 19 parts of hydrated silica, 2.8 parts of sodium lauryl sulfate, 6 parts of propylene glycol, 0.3 part of aloe vera extract, 0.4 part of carboxymethyl cellulose gum, 1.5 parts of mint extract, 0.7 part of xanthan gum, 0.1 part of saccharin sodium, 0.1 part of sodium benzoate and 12 parts of ultrapure water.
Example 2:
grifola frondosa polysaccharide toothpaste is prepared by adding 0.5 part of Grifola frondosa extract and 11.5 parts of ultrapure water to the raw materials in example 1 by weight.
Example 3:
the grifola frondosa polysaccharide toothpaste is prepared from the following raw materials in parts by weight: 68 parts of sorbitol, 18 parts of hydrated silica, 2.5 parts of sodium lauryl sulfate, 5 parts of propylene glycol, 0.3 part of grifola frondosa extract, 0.2 part of aloe vera extract, 0.5 part of carboxymethyl cellulose gum, 1.2 parts of mint extract, 0.6 part of xanthan gum, 0.1 part of saccharin sodium, 0.2 part of sodium benzoate and 15 parts of ultrapure water.
Experimental example 4: study on antibacterial effect of grifola frondosa polysaccharide toothpaste
The experimental method comprises the following steps: the grifola frondosa polysaccharide toothpaste of the above embodiment is compared with other two toothpastes in an antibacterial test of streptococcus mutans, and the concentration of the cultivated streptococcus mutans is 1.5 × 10 determined by adopting a paper diffusion method6CFU/ml bacterial suspension is evenly and crossly smeared on a Sabouraud's dextrose agar culture medium by using an inoculating loop, and the number of the bacterial suspension is 5. Uniformly smearing five kinds of toothpaste in paste form of about 50mg on small round filter paper sheets with the diameter of 6mm, uniformly attaching the small round filter paper sheets to a culture medium, culturing 3 kinds of toothpaste in a constant-temperature incubator at 37 ℃ for 24h, observing the result, and measuring the diameter of a bacteriostatic circle. The experiment is repeated three times, and the average value of the three times is taken as the diameter of the inhibition zone.
The experimental results are as follows:
TABLE 1 bacteriostatic effect of Grifola frondosa polysaccharide
The five kinds of toothpaste have obvious inhibition effect on streptococcus mutans, and the grifola frondosa polysaccharide toothpaste has more obvious inhibition effect than other toothpastes, and can reduce pathogenic factors of oral environment, thereby preventing tooth stain accumulation, effectively cleaning oral cavity and protecting gum health.
Experimental example 5: investigation of human body trial condition
The experimental method comprises selecting 70 cases with light mouth ulcer and 70 cases with periodontitis, wherein the cases have oral cavity peculiar smell of 70 cases and are 25-50 years old. The grifola frondosa polysaccharide toothpaste of example 2 was used once a day, morning and evening, without any drug during the use period. The usage effect is counted as follows.
TABLE 2 Grifola frondosa polysaccharide toothpaste usage statistics
According to the survey feedback, the grifola frondosa polysaccharide toothpaste can effectively relieve various oral problems such as oral ulcer, periodontitis and the like, and has no adverse reaction. Therefore, the grifola frondosa polysaccharide toothpaste can be used for improving various common oral problems, has a good positive effect on tooth protection, and is safe and effective.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. All such modifications, equivalents, improvements and the like which come within the spirit and principle of the invention are intended to be included within the scope of the invention.
Claims (3)
1. The grifola frondosa polysaccharide toothpaste is characterized by being prepared from the following raw materials in parts by weight:
62-72 parts of sorbitol, 15-20 parts of hydrated silica, 2-3 parts of sodium lauryl sulfate, 3-8 parts of propylene glycol, 0.2-0.5 part of grifola frondosa extract, 0.1-0.3 part of aloe vera extract, 0.4-1.0 part of carboxymethyl cellulose gum, 1-2 parts of mint extract, 0.5-1.0 part of xanthan gum, 0.1-0.3 part of saccharin sodium, 0.1-0.3 part of sodium benzoate and 10-25 parts of ultrapure water;
the grifola frondosa is extracted by the following steps: taking a dry product of the grifola frondosa, crushing the dry product into coarse powder, adding 20 times of water, carrying out reflux extraction at the temperature of 90-100 ℃ for 2-4 hours, filtering by using a plate-and-frame filter press, collecting filter residues, adding 7 times of water for secondary extraction, filtering, combining filtrates, and concentrating under reduced pressure at the temperature of 75 ℃ until the relative density is 1.15-1.20 to obtain the grifola frondosa extract.
2. The grifola frondosa polysaccharide toothpaste as claimed in claim 1, which is prepared from the following raw materials in parts by weight:
65-70 parts of sorbitol, 16-18 parts of hydrated silica, 2.2-2.8 parts of sodium lauryl sulfate, 4-7 parts of propylene glycol, 0.3-0.4 part of grifola frondosa extract, 0.1-0.3 part of aloe vera extract, 0.5-0.8 part of carboxymethyl cellulose gum, 1.2-1.8 parts of mint extract, 0.6-0.8 part of xanthan gum, 0.1-0.3 part of saccharin sodium, 0.1-0.3 part of sodium benzoate and 12-20 parts of ultrapure water.
3. The grifola frondosa polysaccharide toothpaste as claimed in claim 1, which is prepared from the following raw materials in parts by weight:
68 parts of sorbitol, 18 parts of hydrated silica, 2.5 parts of sodium lauryl sulfate, 5 parts of propylene glycol, 0.3 part of grifola frondosa extract, 0.2 part of aloe vera extract, 0.5 part of carboxymethyl cellulose gum, 1.2 parts of mint extract, 0.6 part of xanthan gum, 0.1 part of saccharin sodium, 0.2 part of sodium benzoate and 15 parts of ultrapure water.
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| CN201811159118.3A CN108969425B (en) | 2018-09-30 | 2018-09-30 | Grifola frondosa polysaccharide toothpaste |
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| CN201811159118.3A CN108969425B (en) | 2018-09-30 | 2018-09-30 | Grifola frondosa polysaccharide toothpaste |
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| CN108969425B true CN108969425B (en) | 2021-10-22 |
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| CN110897992A (en) * | 2020-01-02 | 2020-03-24 | 广东立爽生物科技有限公司 | Halitosis removing toothpaste and preparation method thereof |
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| JP2005220087A (en) * | 2004-02-06 | 2005-08-18 | Nippon Zettoc Co Ltd | Composition and antioxidant |
| JP2007001961A (en) * | 2005-06-27 | 2007-01-11 | Forestry & Forest Products Research Institute | Antibacterial agent and composition for buccal cavity and food and drink containing the same |
| JP4730991B2 (en) * | 1999-11-29 | 2011-07-20 | 日本ゼトック株式会社 | Oral composition |
| CN106138196A (en) * | 2016-08-24 | 2016-11-23 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Radix Lamiophlomidis Rotatae extract and preparation method thereof |
| CN106137817A (en) * | 2015-04-14 | 2016-11-23 | 拉萨班公湖中药材有限责任公司 | Toothpaste |
| CN106176856A (en) * | 2016-08-24 | 2016-12-07 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Binchotan and preparation method thereof |
| CN107073053A (en) * | 2014-09-17 | 2017-08-18 | 狮王株式会社 | The growth promoter of resident bacteria or intraoral flora improver and composition for oral cavity in non-pathogenic oral cavity |
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2018
- 2018-09-30 CN CN201811159118.3A patent/CN108969425B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4730991B2 (en) * | 1999-11-29 | 2011-07-20 | 日本ゼトック株式会社 | Oral composition |
| JP2005220087A (en) * | 2004-02-06 | 2005-08-18 | Nippon Zettoc Co Ltd | Composition and antioxidant |
| JP2007001961A (en) * | 2005-06-27 | 2007-01-11 | Forestry & Forest Products Research Institute | Antibacterial agent and composition for buccal cavity and food and drink containing the same |
| CN107073053A (en) * | 2014-09-17 | 2017-08-18 | 狮王株式会社 | The growth promoter of resident bacteria or intraoral flora improver and composition for oral cavity in non-pathogenic oral cavity |
| CN106137817A (en) * | 2015-04-14 | 2016-11-23 | 拉萨班公湖中药材有限责任公司 | Toothpaste |
| CN106138196A (en) * | 2016-08-24 | 2016-11-23 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Radix Lamiophlomidis Rotatae extract and preparation method thereof |
| CN106176856A (en) * | 2016-08-24 | 2016-12-07 | 成都体九生物科技有限公司 | Toothpaste containing Radix Notoginseng extract and Binchotan and preparation method thereof |
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