CN106726691A - A kind of shitosan mouthwash and preparation method thereof - Google Patents
A kind of shitosan mouthwash and preparation method thereof Download PDFInfo
- Publication number
- CN106726691A CN106726691A CN201611256886.1A CN201611256886A CN106726691A CN 106726691 A CN106726691 A CN 106726691A CN 201611256886 A CN201611256886 A CN 201611256886A CN 106726691 A CN106726691 A CN 106726691A
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- CN
- China
- Prior art keywords
- shitosan
- mouthwash
- sweetener
- mixed solutions
- preparation
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The present invention discloses a kind of shitosan mouthwash, by weight percentage, its raw material includes 0.2%~5% rilanit special, 0.05%~10% chitosan succinate, 0.01%~0.1% sodium bicarbonate, 1%~10% glycerine, 0.001%~0.005% menthol, 0.001%~0.005% amide of mint, 0.01%~1% sweetener and purified water.The invention also discloses a kind of preparation method of shitosan mouthwash, in dissolving the chitosan in subalkaline mixed solution, so as to prepare the sweet and refreshing inirritative shitosan mouthwash of mouthfeel.A kind of shitosan mouthwash prepared by preparation method of the invention, anti-microbial property is excellent and mouthfeel is sweet and refreshing, unique flavor, is entrance mouthrinse product of good performance.
Description
Technical field
The present invention relates to oral cleaning nursing article technical field, and in particular to be a kind of shitosan mouthwash and its should
The preparation of shitosan mouthwash.
Background technology
Mouthwash is indispensable oral cavity cleaning and nursing amenities in people's daily life, its have cleaning tooth,
Fresh breath, the purpose for reaching holding oral cleaning.In recent years, due to the constantly enhancing of consumer healthcare's consciousness, to water extraction of gargling
Requirement higher is gone out, such as increased the sense of taste demand in some mouthfeels, and needed also have nursing health to act in oral cavity.
Shitosan (Chitosan) is the product after chitin (Chitin) deacetylation, is most basic, most heavy chitin
The derivative wanted.In medical industry, operation suture thread mechanical strength is good as obtained in shitosan, can long-term storage, can be with normal
Rule Disinfection Methods, can be degraded and absorb by people's in-vivo tissue liquid, and surgical thread need not be removed after wound healing.It is made up of shitosan
Artificial skin, with it is soft, comfortable the characteristics of, being covered on burn surface to palliate the agonizing sufferings, accelerating wound healing, promote skin again
It is raw.Shitosan has the advantages that nontoxic, biodegradable, good biocompatibility, makes it in biomaterial, pharmaceutical carrier, medical
And the field such as agricultural bacteriocide, food fresh keeping, environmental protection, veterinary drug and feed addictive, health products has wide research and application preceding
Scape.
Shitosan dissolves in diluted acid, formic acid, acetic acid, but water insoluble and most organic solvents.It is presently considered shell
Glycan locks onto water-soluble chitosan and is added in mouthrinse product, such as：Chitosan hydrochloride, carboxymethyl chitosan, shell
Oligosaccharides etc..But be found through experiments that, above-mentioned substance mouthfeel is sour and astringent, and particularly chitosan hydrochloride is not only sour and astringent but also bitter,
It is not suitable for addition in the final finished of mouthwash.This kind of sour and astringent bitter mouthfeel, even if regulation pol is also difficult to completely
Cover, the big difficult point as shitosan mouthwash commercialization.
The content of the invention
It is an object of the invention to provide the shitosan mouthwash that a kind of anti-microbial property is excellent, mouthfeel is sweet and refreshing, unique flavor,
It is entrance mouthrinse product of good performance.
The present invention also aims to provide a kind of preparation method of shitosan mouthwash, alkalescence is dissolved the chitosan in
Mixed solution in, mixed with the other components of mouthwash, so as to prepare the sweet and refreshing inirritative shitosan mouthwash of mouthfeel.
In order to reach above-mentioned purpose, solution of the invention is：
A kind of shitosan mouthwash, by weight percentage, its raw material and consumption are：
The rilanit special is Cremophor RH40.
The sweetener is Sucralose or saccharin sodium.
The preparation method of the shitosan mouthwash, comprises the following steps：
(1) by formulation weight ratio, by 0.001%~0.005% menthol, 0.001%~0.005% peppermint acyl
Amine, 1%~10% glycerine are added separately in 0.2%~5% rilanit special, are uniformly mixing to obtain A group mixed solutions；
(2) by 0.01%~0.1% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline little Su
Beat solution；
(3) 0.05%~10% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation
In, stir and evenly mix, 0.01%~1% sweetener is subsequently added into, stirring is completely dissolved to the sweetener, obtains the mixing of B groups
Solution；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product the shell and gather
Sugared mouthwash.
In step (1), the rilanit special is Cremophor RH40.
In step (3), the sweetener is Sucralose or saccharin sodium.
After adopting the above technical scheme, a kind of shitosan mouthwash that the present invention is prepared, its raw materials of chitosan amber
Hydrochlorate can be dissolved in the saleratus solution of alkalescence, overcome the sour and astringent bitter problem that chitosan succinate is brought,
So that mouthwash good mouthfeel, the glycerine as cleaning agent for mouth cavity and solvent is smaller to the excitant in oral cavity, is brought to mouthwash
The taste that mouthwash is improved while antibacterial action is received.
Therefore, a kind of shitosan mouthwash of the invention, anti-microbial property is excellent and mouthfeel is sweet and refreshing, unique flavor, is entrance
The good mouthrinse product of energy.
Specific embodiment
In order to technical scheme is explained further, the present invention is explained in detail below by specific embodiment
State.
A kind of shitosan mouthwash, by weight percentage, its raw material and consumption are：
The rilanit special is Cremophor RH40.
The sweetener is Sucralose or saccharin sodium.
The preparation method of the shitosan mouthwash, comprises the following steps：
(1) by formulation weight ratio, by 0.001%~0.005% menthol, 0.001%~0.005% peppermint acyl
Amine, 1%~10% glycerine are added separately in 0.2%~5% rilanit special, are uniformly mixing to obtain A group mixed solutions；
(2) by 0.01%~0.1% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline little Su
Beat solution；
(3) 0.05%~10% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation
In, stir and evenly mix, 0.01%~1% sweetener is subsequently added into, stirring is completely dissolved to the sweetener, obtains the mixing of B groups
Solution；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product the shell and gather
Sugared mouthwash.
In step (1), the rilanit special is Cremophor RH40.
In step (3), the sweetener is Sucralose or saccharin sodium.
Embodiment one
(1) by formulation weight ratio, 0.003% menthol, 0.004% amide of mint, 5% glycerine are separately added into
To in 1.5% Cremophor RH40, A group mixed solutions are uniformly mixing to obtain；
(2) by 0.1% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline saleratus solution；
(3) 0.1% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation, is stirred
Mix, be subsequently added into 0.05% Sweetener Sucralose, stirring is completely dissolved to Sucralose, obtains B group mixed solutions；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product shitosan and gargle
Saliva.
Embodiment two
(1) by formulation weight ratio, 0.003% menthol, 0.003% amide of mint, 5% glycerine are separately added into
To in 1% Cremophor RH40, A group mixed solutions are uniformly mixing to obtain；
(2) by 0.05% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline saleratus solution；
(3) 0.05% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation, is stirred
Mix, be subsequently added into 0.1% sweetener saccharin sodium, stirring is completely dissolved to saccharin sodium, obtains B group mixed solutions；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product shitosan and gargle
Saliva.
Embodiment three
(1) by formulation weight ratio, 0.005% menthol, 0.005% amide of mint, 10% glycerine are added respectively
Enter in 3% Cremophor RH40, be uniformly mixing to obtain A group mixed solutions；
(2) by 0.01% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline saleratus solution；
(3) 0.05% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation, is stirred
Mix, be subsequently added into 0.8% Sweetener Sucralose, stirring is completely dissolved to Sucralose, obtains B group mixed solutions；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product shitosan and gargle
Saliva.
Example IV
(1) by formulation weight ratio, 0.003% menthol, 0.003% amide of mint, 1% glycerine are separately added into
To in 5% Cremophor RH40, A group mixed solutions are uniformly mixing to obtain；
(2) by 0.04% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline saleratus solution；
(3) 3% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation, stirring is mixed
It is even, 0.08% Sweetener Sucralose is subsequently added into, stirring is completely dissolved to Sucralose, obtains B group mixed solutions；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product shitosan and gargle
Saliva.
Embodiment five
(1) by formulation weight ratio, 0.003% menthol, 0.003% amide of mint, 5% glycerine are separately added into
To in 1% Cremophor RH40, A group mixed solutions are uniformly mixing to obtain；
(2) by 0.01% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline saleratus solution；
(3) 6% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation, stirring is mixed
It is even, 1% Sweetener Sucralose is subsequently added into, stirring is completely dissolved to Sucralose, obtains B group mixed solutions；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product shitosan and gargle
Saliva.
Embodiment six
(1) by formulation weight ratio, 0.003% menthol, 0.003% amide of mint, 5% glycerine are separately added into
To in 2.5% Cremophor RH40, A group mixed solutions are uniformly mixing to obtain；
(2) by 0.07% sodium bicarbonate be dissolved in purified water be configured to pH=7~8 in weakly alkaline saleratus solution；
(3) 10% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation, stirring is mixed
It is even, 0.2% Sweetener Sucralose is subsequently added into, stirring is completely dissolved to Sucralose, obtains B group mixed solutions；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product shitosan and gargle
Saliva.
Above-described embodiment and non-limiting product form of the invention and style, the ordinary skill people of any art
Appropriate change or modification that member is done to it, all should be regarded as not departing from patent category of the invention.
Claims (6)
1. a kind of shitosan mouthwash, it is characterised in that：By weight percentage, its raw material and consumption are：
2. a kind of shitosan mouthwash according to claim 1, it is characterised in that：The rilanit special is PEG-40 hydrogen
Change castor oil.
3. a kind of shitosan mouthwash according to claim 1, it is characterised in that：The sweetener be Sucralose or
Saccharin sodium.
4. a kind of preparation method of shitosan mouthwash as claimed in claim 1 is prepared, it is characterised in that：Including following step
Suddenly：
(1) by formulation weight ratio, by 0.001%~0.005% menthol, 0.001%~0.005% amide of mint, 1%
~10% glycerine is added separately in 0.2%~5% rilanit special, is uniformly mixing to obtain A group mixed solutions；
(2) 0.01%~0.1% sodium bicarbonate is dissolved in the saleratus solution that purified water is configured to pH=7~8；
(3) 0.05%~10% chitosan succinate is dissolved in the saleratus solution in step (2) under agitation, is stirred
Mixing is mixed, 0.01%~1% sweetener is subsequently added into, stirring is completely dissolved to the sweetener, obtains B group mixed solutions；
(4) B group mixed solutions are added gradually in A group mixed solutions under agitation, are well mixed, obtained final product the shitosan and gargle
Saliva.
5. the preparation method of a kind of shitosan mouthwash according to claim 4, it is characterised in that：It is described in step (1)
Rilanit special is Cremophor RH40.
6. the preparation method of a kind of shitosan mouthwash according to claim 4, it is characterised in that：It is described in step (3)
Sweetener is Sucralose or saccharin sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611256886.1A CN106726691A (en) | 2016-12-30 | 2016-12-30 | A kind of shitosan mouthwash and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611256886.1A CN106726691A (en) | 2016-12-30 | 2016-12-30 | A kind of shitosan mouthwash and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106726691A true CN106726691A (en) | 2017-05-31 |
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ID=58954547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611256886.1A Pending CN106726691A (en) | 2016-12-30 | 2016-12-30 | A kind of shitosan mouthwash and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693442A (en) * | 2017-09-14 | 2018-02-16 | 南通荣成医药化工有限公司 | A kind of efficient sterilizing mouthwash |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102775518A (en) * | 2012-08-01 | 2012-11-14 | 浙江金壳生物化学有限公司 | Chitosan succinate flavor enhancer |
| CN104434699A (en) * | 2014-12-18 | 2015-03-25 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
| CN105326651A (en) * | 2015-06-27 | 2016-02-17 | 合肥九研医药科技开发有限公司 | Mouthwash and preparation method thereof |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
-
2016
- 2016-12-30 CN CN201611256886.1A patent/CN106726691A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102775518A (en) * | 2012-08-01 | 2012-11-14 | 浙江金壳生物化学有限公司 | Chitosan succinate flavor enhancer |
| CN104434699A (en) * | 2014-12-18 | 2015-03-25 | 东莞市阿比亚能源科技有限公司 | Tooth washing liquid |
| CN105326651A (en) * | 2015-06-27 | 2016-02-17 | 合肥九研医药科技开发有限公司 | Mouthwash and preparation method thereof |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107693442A (en) * | 2017-09-14 | 2018-02-16 | 南通荣成医药化工有限公司 | A kind of efficient sterilizing mouthwash |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170531 |
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| RJ01 | Rejection of invention patent application after publication |