CN108785115A - A kind of teenagers growth phase oral care tooth liquid and preparation method thereof - Google Patents
A kind of teenagers growth phase oral care tooth liquid and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of teenagers growth phase oral care tooth liquid, it is characterized in that, according to the mass fraction, including urine assist plain solution 140-170 parts, 2-5 parts of xanthan gum, 20-30 parts of glycerine, 1-3 parts of sodium lactate, 0.2-0.8 parts of glycyrrhizic acid, 0.05-0.2 parts of D-pantothenyl aleohol, 0.05-0.2 parts of niacinamide, 0.1-0.5 parts of Sucralose, 0.1-0.5 parts of potassium cinnamate, 0.02-0.1 parts of citric acid, 1-3 parts of sodium monofluorophosphate, 0.1-1 parts of sodium pyrophosphate, 0.01-0.1 parts of zinc lactate.Product of the present invention effectively pre- anti-caries and periodontosis, inhibition plaque bacteria breeding can resist bacterium erosion, and firm tooth maintains Oral health behaviours balance, oral cavity acid-base value is made to maintain normal level, mothproof to have the function that.
Description
Technical field
The present invention relates to field of oral care, more particularly to a kind of teenagers growth phase oral care tooth liquid and its preparation side
Method.
Background technology
Oral health is the important component of our whole body healths, and it is strong that oral health directly or indirectly influences whole body
Health.Proverb is said right：Illness finds its way in by the mouth.Oral cavity is respiratory tract, gastral entrance, has chewing, swallows, language expression etc. is important
Physiological function.The environment of warm and moist in oral cavity provides good living environment for some pathogenic microorganisms and breeding is empty
Between, it is one of the important channel of pathogenic microorganism intrusion body.These microorganism long-term existence can cause or aggravate with oral cavity
Many systemic diseases, such as coronary heart disease, diabetes etc..Present most common disease is basically dental caries in mouth disease
And periodontal disease, they can destroy supporting tissue around hard tooth tissue and tooth, once being formed dental caries or periodontosis, remove
The problems such as influencing normal chewing, speech, swallowing, outside the functions such as beauty, can also cause social difficulty, mental handicape.
Oral problem may result in or aggravate the generation of some systemic diseases.Modern medicine study proves, oral cavity disease
Disease can not only cause headache, ulcer, sphagitis, some common diseases such as tonsillitis, pneumonia, bronchitis, but also
It can cause chronic enteritis, it is the gastrointestinal systems such as intestinal tuberculosis disease and diabetes, rheumatic heart disease, myocarditis, intracardiac
Some many and uncommon systemic diseases such as film inflammation, ephritis, arthritis, septicemia.And the saprodontia that we are frequently seen is more
It is that the third-largest Chronic Non-Communicable Diseases after cardiovascular and cerebrovascular disease, cancer has been classified as by the World Health Organization, to us
Human body harm is great.
Oral health is particularly important for teenager, shows according to investigations, in the common mouth disease of teenager, always suffers from dental caries
Rate is 39.95%, and patient's dental caries are 1.20, and periodontosis recall rate is respectively 89.67%, 84.52%.Mouth disease can prevent controllably
It can control, expert introduction, dental caries and periodontosis are bacterial infection diseases, and the bacterium of plaque and its product are to cause dental caries and tooth
Dental caries and periodontosis would not occur for the initiation factor of all diseases, no bacterial plaque microorganism.Prevention and control mouth disease needs a human mouth
It safeguards and special maintenance is combined.A human mouth safeguard include effectively brush teeth, balanced diet, reasonable employment fluoride, regular mouth
Chamber inspection etc.；It includes topical application fluoride, fissure blockade and scaling (toothwash) etc. that professional oral cavity, which is safeguarded,.
Tooth liquid is common dental care products in daily life, with the continuous development of science and technology, technological equipment
It continuously improves and perfect, various types of products are come out one after another, and the quality and grade of product is continuously improved, the type beautiful jade of tooth liquid
It meets the eye on every side, for this purpose, becoming an important topic for teenager oral cavity problem design oral nursing liquid liquid occurred frequently.
Invention content：
It is an object of the invention to overcome the deficiencies of existing technologies, provide a kind of teenagers growth phase oral care tooth liquid and
Preparation method.
The present invention uses following technical scheme：
A kind of teenagers growth phase oral care tooth liquid, which is characterized in that according to the mass fraction, including urine assists plain solution
140-170 parts, 2-5 parts of xanthan gum, 20-30 parts of glycerine, 1-3 parts of sodium lactate, 0.2-0.8 parts of glycyrrhizic acid, D-pantothenyl aleohol 0.05-0.2
Part, 0.05-0.2 parts of niacinamide, 0.1-0.5 parts of Sucralose, 0.1-0.5 parts of potassium cinnamate, 0.02-0.1 parts of citric acid, single fluorine
1-3 parts of sodium phosphate, 0.1-1 parts of sodium pyrophosphate, 0.01-0.1 parts of zinc lactate.
Preferably, according to the mass fraction, including urine assists 152 parts of plain solution, 3 parts of xanthan gum, 24 parts of glycerine, sodium lactate 2.2
Part, 0.44 part of glycyrrhizic acid, 0.1 part of D-pantothenyl aleohol, 0.1 part of niacinamide, 0.18 part of Sucralose, 0.32 part of potassium cinnamate, citric acid
0.06 part, 1.72 parts of sodium monofluorophosphate, 0.6 part of sodium pyrophosphate, 0.08 part of zinc lactate.
Preferably, the urine is assisted in plain solution, and it is 2-5% that urine, which assists the content of element,.
It is further preferred that the urine is assisted in plain solution, it is 3.95% that urine, which assists the content of element,.
A kind of preparation method of teenagers growth phase oral care tooth liquid, which is characterized in that include the following steps：
(1) xanthan gum, glycerine, sodium lactate are mixed into dispersion, then plain solution uniform stirring under 70-90 DEG C of water temperature is assisted with urine
5-15 minutes, it is down to room temperature, urine is obtained and assists plain colloidal solution；
(2) by glycyrrhizic acid, D-pantothenyl aleohol, niacinamide, Sucralose, potassium cinnamate, citric acid, sodium monofluorophosphate, pyrophosphoric acid
Sodium, zinc lactate assist plain solution to dissolve to urinate, and obtain the hydrotrope；
(3) urine is added in the hydrotrope to assist in plain colloidal solution, uniform stirring 10-30min filters to get teenagers growth
Phase oral care tooth liquid.
Preferably, the water temperature in step (1) is 80 DEG C.
Preferably, it is that urine assists the 65% of plain solution total amount that the urine in step (1), which assists plain solution, and the urine in step (3) assists element
Solution is that urine assists the 35% of plain solution total amount.
Beneficial effects of the present invention：
1, product of the present invention pure and fresh tasty and refreshing, disappear with heat-clearing fire, strong root is good for tooth, nutrition gum and the work for improving periodontal health
With, easy to use, health, safety.
2, product of the present invention effectively pre- anti-caries and periodontosis, inhibition plaque bacteria breeding can resist bacterium erosion, firm
Tooth maintains Oral health behaviours balance, oral cavity acid-base value is made to maintain normal level, mothproof to have the function that.
Specific implementation mode
With reference to specific embodiment, the present invention is described in further detail.
Embodiment 1：
Teenagers growth phase oral care tooth liquid
Raw material：Urine assists 152 parts of plain solution, 3 parts of xanthan gum, 24 parts of glycerine, 2.2 parts of sodium lactate, 0.44 part of glycyrrhizic acid, D- general
0.1 part of alcohol, 0.1 part of niacinamide, 0.18 part of Sucralose, 0.32 part of potassium cinnamate, 0.06 part of citric acid, sodium monofluorophosphate 1.72
Part, 0.6 part of sodium pyrophosphate, 0.08 part of zinc lactate.It is 3.95% that urine, which assists the content of element,.
Preparation process：
(1) xanthan gum, glycerine, sodium lactate are mixed into dispersion, then plain solution uniform stirring 10 under 80 DEG C of water temperatures is assisted with urine
Minute, it is down to room temperature, urine is obtained and assists plain colloidal solution；
(2) by glycyrrhizic acid, D-pantothenyl aleohol, niacinamide, Sucralose, potassium cinnamate, citric acid, sodium monofluorophosphate, pyrophosphoric acid
Sodium, zinc lactate assist plain solution to dissolve to urinate, and obtain the hydrotrope；
(3) hydrotrope is added in allantoin colloidal solution, uniform stirring 15min, filtering is to get the teenagers growth phase mouthful
Chamber nurses tooth liquid.
It is that urine assists the 65% of plain solution total amount that urine in step (1), which assists plain solution, and it is urine that the urine in step (3), which assists plain solution,
Assist the 35% of plain solution total amount.
Embodiment 2：
Teenagers growth phase oral care tooth liquid
Raw material：Urine assists 140 parts of plain solution, 2 parts of xanthan gum, 30 parts of glycerine, 3 parts of sodium lactate, 0.2 part of glycyrrhizic acid, D-pantothenyl aleohol
0.2 part, 0.2 part of niacinamide, 0.1 part of Sucralose, 0.1 part of potassium cinnamate, 0.1 part of citric acid, 3 parts of sodium monofluorophosphate, burnt phosphorus
0.1 part of sour sodium, 0.01 part of zinc lactate.It is 2% that urine, which assists the content of element,.
Preparation process：
(1) xanthan gum, glycerine, sodium lactate are mixed into dispersion, then plain solution uniform stirring 15 under 90 DEG C of water temperatures is assisted with urine
Minute, it is down to room temperature, urine is obtained and assists plain colloidal solution；
(2) by glycyrrhizic acid, D-pantothenyl aleohol, niacinamide, Sucralose, potassium cinnamate, citric acid, sodium monofluorophosphate, pyrophosphoric acid
Sodium, zinc lactate assist plain solution to dissolve to urinate, and obtain the hydrotrope；
(3) hydrotrope is added in allantoin colloidal solution, uniform stirring 10min, filtering is to get the teenagers growth phase mouthful
Chamber nurses tooth liquid.
It is that urine assists the 65% of plain solution total amount that urine in step (1), which assists plain solution, and it is urine that the urine in step (3), which assists plain solution,
Assist the 35% of plain solution total amount.
Embodiment 3：
Teenagers growth phase oral care tooth liquid
Raw material：Urine assists 170 parts of plain solution, 5 parts of xanthan gum, 20 parts of glycerine, 1 part of sodium lactate, 0.8 part of glycyrrhizic acid, D-pantothenyl aleohol
0.05 part, it is 0.05 part of niacinamide, 0.5 part of Sucralose, 0.5 part of potassium cinnamate, 0.02 part of citric acid, 1 part of sodium monofluorophosphate, burnt
1 part of sodium phosphate, 0.1 part of zinc lactate.It is 5% that urine, which assists the content of element,.
Preparation process：
(1) xanthan gum, glycerine, sodium lactate are mixed into dispersion, then assists plain solution uniform stirring 5 under 70 DEG C of water temperatures to divide with urine
Clock is down to room temperature, obtains urine and assists plain colloidal solution；
(2) by glycyrrhizic acid, D-pantothenyl aleohol, niacinamide, Sucralose, potassium cinnamate, citric acid, sodium monofluorophosphate, pyrophosphoric acid
Sodium, zinc lactate assist plain solution to dissolve to urinate, and obtain the hydrotrope；
(3) hydrotrope is added in allantoin colloidal solution, uniform stirring 30min, filtering is to get the teenagers growth phase mouthful
Chamber nurses tooth liquid.
It is that urine assists the 65% of plain solution total amount that urine in step (1), which assists plain solution, and it is urine that the urine in step (3), which assists plain solution,
Assist the 35% of plain solution total amount.
Teenager's oral care tooth liquid using effect is evaluated：
The teenager that 60 ages of screening are 12-14 Sui, male to female ratio 1:1, and it is randomly divided into 2 groups.
Implementation and process：
Consumer uses the tooth liquid for preparing of embodiment 1 and blank control toothpaste respectively.After continuous use one month, pay a return visit
And questionnaire is recycled, record consumer carries out statistical comparison using the oral condition after test tooth liquid.
Consumer evaluation's effect：
Using the child of tooth liquid group prepared by the present invention, the original dental plaque in oral cavity does not increase, and the mean ph value of dental plaque fluid is bright
It is aobvious to be higher than control group, test result：
Control group 6.15 ± 0.51 6.14 ± 0.62 6.09 ± 0.61
Test group 6.25 ± 0.52 6.49 ± 0.48 6.61 ± 0.49
Should the result shows that, the present invention has apparent effect to the maintenance of teenager's oral environment, can effectively play prevention decayed tooth,
Saprodontia cleans the effect in oral cavity.It respectively brushes teeth 2 minutes sooner or later daily and prevents stomatitis, this product RDA≤30 will not abrading tooth enamel
This product protection enamel is used for a long time and prevents stomatitis.
Above-described embodiment is merely illustrative of the technical solution of the present invention and is not intended to limit it, all without departing from the present invention
Any modification of spirit and scope or equivalent replacement should all cover the range in technical solution of the present invention.
Claims (7)
1. a kind of teenagers growth phase oral care tooth liquid, which is characterized in that according to the mass fraction, including urine assists plain solution 140-
170 parts, 2-5 parts of xanthan gum, 20-30 parts of glycerine, 1-3 parts of sodium lactate, 0.2-0.8 parts of glycyrrhizic acid, 0.05-0.2 parts of D-pantothenyl aleohol, cigarette
0.05-0.2 parts of amide, 0.1-0.5 parts of Sucralose, 0.1-0.5 parts of potassium cinnamate, 0.02-0.1 parts of citric acid, single fluorophosphoric acid
1-3 parts of sodium, 0.1-1 parts of sodium pyrophosphate, 0.01-0.1 parts of zinc lactate.
2. a kind of teenagers growth phase oral care tooth liquid according to claim 1, which is characterized in that press mass fraction
Meter, including urine assist 152 parts of plain solution, 3 parts of xanthan gum, 24 parts of glycerine, 2.2 parts of sodium lactate, 0.44 part of glycyrrhizic acid, D-pantothenyl aleohol 0.1
Part, 0.1 part of niacinamide, 0.18 part of Sucralose, 0.32 part of potassium cinnamate, 0.06 part of citric acid, 1.72 parts of sodium monofluorophosphate, coke
0.6 part of sodium phosphate, 0.08 part of zinc lactate.
3. a kind of teenagers growth phase oral care tooth liquid according to claim 1, which is characterized in that the urine assists element
In solution, it is 2-5% that urine, which assists the content of element,.
4. a kind of teenagers growth phase oral care tooth liquid according to claim 3, which is characterized in that the urine assists element
In solution, it is 3.95% that urine, which assists the content of element,.
5. a kind of preparation method of teenagers growth phase oral care tooth liquid, which is characterized in that include the following steps：
(1) xanthan gum, glycerine, sodium lactate are mixed into dispersion, then plain solution uniform stirring 5-15 under 70-90 DEG C of water temperature is assisted with urine
Minute, it is down to room temperature, urine is obtained and assists plain colloidal solution；
(2) by glycyrrhizic acid, D-pantothenyl aleohol, niacinamide, Sucralose, potassium cinnamate, citric acid, sodium monofluorophosphate, sodium pyrophosphate, breast
Sour zinc assists plain solution to dissolve to urinate, and obtains the hydrotrope；
(3) urine is added in the hydrotrope to assist in plain colloidal solution, uniform stirring 10-30min, filtering is to get the teenagers growth phase mouthful
Chamber nurses tooth liquid.
6. a kind of preparation method of teenagers growth phase oral care tooth liquid according to claim 5, which is characterized in that step
Suddenly the water temperature in (1) is 80 DEG C.
7. a kind of preparation method of teenagers growth phase oral care tooth liquid according to claim 5, which is characterized in that step
Suddenly it is that urine assists the 65% of plain solution total amount that the urine in (1), which assists plain solution, and it is that urine assists plain solution total that the urine in step (3), which assists plain solution,
The 35% of amount.
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| CN201810654550.3A CN108785115A (en) | 2018-06-22 | 2018-06-22 | A kind of teenagers growth phase oral care tooth liquid and preparation method thereof |
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| CN201810654550.3A CN108785115A (en) | 2018-06-22 | 2018-06-22 | A kind of teenagers growth phase oral care tooth liquid and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123649A (en) * | 2019-06-05 | 2019-08-16 | 广东勉衡生物科技有限公司 | A kind of liquid tooth paste and preparation method thereof |
| CN115177543A (en) * | 2022-08-31 | 2022-10-14 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and anticarious composition containing L-lactate, oral care product and preparation method and application thereof |
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| CN101292952A (en) * | 2008-06-12 | 2008-10-29 | 武汉华纳生物工程有限公司 | Glycyrrhizic acid, biogastrone acid or its salt, derivative temperature sensing gel rubber, preparation method and application thereof |
| CN101757091A (en) * | 2008-12-26 | 2010-06-30 | 贵州益佰制药股份有限公司 | Extract composite preparation for treating oral ulcer and preparation method thereof |
| CN102552061A (en) * | 2012-02-17 | 2012-07-11 | 广东名臣有限公司 | Toothpaste for effectively improving halitosis |
| CN106821775A (en) * | 2017-01-18 | 2017-06-13 | 鹰仕达（中国）有限公司 | A kind of antiallergic toothpaste and preparation method thereof |
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2018
- 2018-06-22 CN CN201810654550.3A patent/CN108785115A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101292952A (en) * | 2008-06-12 | 2008-10-29 | 武汉华纳生物工程有限公司 | Glycyrrhizic acid, biogastrone acid or its salt, derivative temperature sensing gel rubber, preparation method and application thereof |
| CN101757091A (en) * | 2008-12-26 | 2010-06-30 | 贵州益佰制药股份有限公司 | Extract composite preparation for treating oral ulcer and preparation method thereof |
| CN102552061A (en) * | 2012-02-17 | 2012-07-11 | 广东名臣有限公司 | Toothpaste for effectively improving halitosis |
| CN106821775A (en) * | 2017-01-18 | 2017-06-13 | 鹰仕达（中国）有限公司 | A kind of antiallergic toothpaste and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110123649A (en) * | 2019-06-05 | 2019-08-16 | 广东勉衡生物科技有限公司 | A kind of liquid tooth paste and preparation method thereof |
| CN115177543A (en) * | 2022-08-31 | 2022-10-14 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and anticarious composition containing L-lactate, oral care product and preparation method and application thereof |
| CN115177543B (en) * | 2022-08-31 | 2024-01-09 | 重庆登康口腔护理用品股份有限公司 | Antibacterial caries preventing composition containing L-lactate, oral care product and preparation method and application thereof |
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Application publication date: 20181113 |