KR20100042364A - Improvement halitosis stomach oral - Google Patents

Abstract

PURPOSE: A composition is provided to effectively remove odor and treat oral ozostomia and intestinal ozostomia. CONSTITUTION: A composition for treating oral ozostomia and intestinal ozostomia contains 20-70 weight% of geranium nepalense subspthunbergi, 10-35 weight% of poncirus tritoliata, 10-30 weight% of xylitol, 5-30 weight% of stebioside, and 1-5 weight%, and 1-15 weight% of menthol The composition is used in the form of powder, tablet, pill, or liquid.

Description

Composition method for improving oral cause and gastrointestinal cause at the same time {IMPROVEMENT HALITOSIS STOMACH ORAL}

The present invention improves oral causative odor improvement and gastrointestinal disturbance causal odor by using anti-corrosive heterogeneous grass, tanza, and also to prevent and treat stomatitis, needle inflammation, tooth decay, gum disease, tonsillitis, cold oral disease, etc. The present invention relates to a method for providing a composition that simultaneously improves oral and gastrointestinal gastrointestinal tract with excellent economic efficiency and high functionality.

In order to solve the above problems, the bactericidal antibacterial and gastrointestinal disorders safely against the cause of bad breath of the oral cavity by using the natural anti-corrosive heterogeneous grass, tanza, which have a wide range of excellent functions such as sterilization antibacterial and gastrointestinal digestive disorder improvement. Check the effect of improvement on bad breath, 20 ~ 70% by weight of heterozygous grass and 10 ~ 35% by weight of tanza: 10 ~ 30% by weight of xylitol, 5 ~ 30% by weight of enzyme stevioside, 1 ~ 15% by weight of sweetener and freshener %,

The main composition, the bactericidal antibacterial to the bad breath cause of the oral cavity, and also prevents the decay of the remaining food residues of the oral cavity, and oral cleaning and elimination of bad breath, improve gastrointestinal digestive disorders, improve the gastrointestinal digestive odor, The antimicrobial effect of antibacterial stomatitis, needles, tooth decay, gum disease, tonsillitis, sore throat, cold, and oral disease, which are highly effective in the treatment and prevention of oral cause and gastrointestinal odor, resulted in the completion of the composition.

As a herbal medicine herbal medicine that has been used rarely since ancient times, it has excellent antibacterial and antimicrobial effect and has no resistance to gastrointestinal digestive organs and has no side effects even when ingested. Pharmacological studies have also confirmed that the use of heterozygous pools can be effective in preventing or treating stomatitis, needle inflammation, tooth disease, tonsillitis, sore throat, etc. Can see,

Heterogeneous grass is called by various names in addition to Noguwancho Hyuncho hand-leaf grass and rattan grass.

[Literature 1] Heterophyllaceae (Nogwancho, Hyuncho): perennial herb with dicotyledonous rat rats

Scientific name: geranium nepalense subspthunbergi

It contains a large amount of tannin and quercetin, which has anti-inflammatory hemostatic and sterilizing action, and is used as a medicine for abdominal ulcer, gastric ulcer, duodenal ulcer, etc. , 3),

[Document 2] Herbal Pharmacology-Hyuncho, Efficacy: Converging Gypsyhari (收斂 址 瀉 下痢),

Antibacterial and Other Actions: Herbs are bactericidal against dysentery, typhoid, E, coli,

Clinical application: formal branch medicine, palliative medicine, astringent branch medicine, substitute for tea, omission,

Commonly used, irrespective of constipation, and large intakes have no side effects,

(Refer to the Korean Pharmacy Professor's Guidebook Publishing, published in 1998, pp. 128-129),

[Utilization 3] Practical Dong Pharmacology-Hand-leaf Herbs (Herbaceous and Murciforma) Weakness: This drug acts as astringent diarrhea due to tannin component, Staphylococcus aureus, Escherichia coli, especially antibiotic-resistant bacteria, resistant Escherichia coli, It acts as a bacterium against resistant pathogens,

(See Cha Jin-hyeon, Published by Chosun Nationalist People's Republic of Korea, published in January 2000, p. 348)

The Tenza is said to ripen ripe fruit, the late crust and immature fruit.

[Article 4] Tanja: scientific name: poncirus tritoliata, deciduous shrub with dicotyledonous rats, L., (Refer to Naver Doosan Encyclopedia, 2008,7,7)

[Article 5] Tenza: Fruit of a tanza, good scent and medicinal,

(See Naver Korean Dictionary)

[6] Herbal Biopharmaceuticals-Jisil, Pharmacology: antiviral, anti-inflammatory,

Efficacy: to enter the destruction, rain, stomach, colon, abbreviation, summary of the destruction, food stagnation is used,

(Kim, Dae-Geun, Kim, Man-Bae, Kim, Hoon, Park, Jin-Han, Lim Jong-Pil Hong Book Publishing, Shinil Corp., 2003, p. 219)

[Reference 7] Herbology-Knowledge, clinical application: Lack of internal medicine, obesity pain, post-mortem syndrome, abduction, dropping, and written as a medicine (Contact Academy Book p. 425) )

[Pharmacology 8] Herbal Pharmacology-Jisil, Pharmacology: The pharmacological action of Jisil is basically the same as perception, and has almost the same pharmacological action.

Antiviral action: Protects mice cells for 24 hours after incubation with fibroblasts and exposure to bullous stomatitis virus

When hesperidin contained in fruit is pretreated with hela cells, it prevents virus infection, which is anti-inflammatory, (see Kim Ho-cheol, 2001, p. 270).

In addition, algae grass and abundant natural dietary fiber, and tanza is known to have a lot of nutrients such as vitamin c, such as tangerine.

Bad breath improver to improve the oral cause and gastrointestinal cause at the same time using the easy pull tan of the present invention has not been reported in the prior art, so far,

The present invention relates to a composition method for simultaneously eliminating oral cause and gastrointestinal cause and removal, specifically, an alimentary grass, tanza, which is an anti-corrosive substance, has excellent natural sterilization and antibacterial effect, and is excellent in improving gastrointestinal disorders. It is composed of xylitol, enzyme stevioside, and menthol as a sweetener and a refreshing agent to improve oral cause and gastrointestinal cause at the same time.It also treats stomatitis, tooth decay, tooth disease, sore throat, tonsillitis, cold and oral disease due to bactericidal and antibacterial effects. In order to provide a method for the composition of bad breath containing dendritic tanza having a wide range of functions that are very excellent in prevention.

The most common causes of bad breath are oral cause and gastrointestinal cause.

Oral cause odor is caused by many anaerobic bacteria hiding in the neck, such as between the teeth and gums in the mouth and the surface tissues of the tongue.It is known to be caused by volatile sulfur compounds caused by the decay and decomposition of food residues. Inflammation of oral disease, tonsillitis, sore throat, sinusitis, rhinitis, and other bacteria contained in the oral cavity are caused by various bacterial activities such as protein degradation.

Gastrointestinal cause bad breath is caused directly by gastrointestinal digestive disorders, or odorous substances such as phlegm fusuru due to sinusitis rhinitis pharyngitis tonsillitis bronchitis flow into the stomach through the esophagus during food intake or during sleep. It is also known as a secondary cause of gastrointestinal causes of bad breath caused by accumulation in the stomach together with the stomach.

As described above, the causes of bad breath are various, and only oral cause bad breath occurs, but most of them cause oral and gastrointestinal cause bad breath at the same time. It's harder to treat.

If you look at the dictionary meaning of bad breath,

It is caused by diseases such as oral cavity, ear, nasal cavity, upper respiratory tract and stomach, but it may be an inherent smell close to body odor.

Pathological bad breath is caused by diseases of the digestive system and by diseases of the respiratory system. Nasal and paranasal sinuses, trachea, bronchial and lung diseases, esophagus and stomach diseases, bad breath, omission,

Doosan Encyclopedia

Gastrointestinal causation can be distinguished by the fact that bad breath is more severe in the afternoon when food is gathered in the gastrointestinal digestive organs than in the morning.

The bad breath is one of the diseases that suffer from such problems as oral cause odor, gastrointestinal cause odor, and so on, and people around them avoid it.

However, in order to treat, it is inconvenient to go to a dentist or hospital, etc., long treatment time and high treatment cost. Therefore, many people have been asking for a simpler and easier way to get rid of bad breath. Due to the market, many bad breath removers are sold.

Commercialized bad breath removers have been used to prepare oral breath fresheners using synthetic chemicals, but they are used as synthetic chemical raw materials for oral use, and must be spit-out after use. It was uncomfortable to use, and spit out and left the drug in the mouth unnecessarily, causing anxiety in health, and frequent use of the drug caused the mouth to break down and suffered secondary pain. do,

In addition, the bad breath of the mouth improves, but can not eat, gastrointestinal cause bad breath is still intact, less effective in removing bad breath,

 Commercialized products include Listerlne solution of Johnson & Johnson Korea, Gagreen solution of Dong-A Pharmaceutical, and Care Gargle Solution of Hanmi Pharmaceutical.

As a deodorant for eating, seoheung capsules are sold as a deodorant for capsules, but this is limited to the removal of bad breath of oral causes, so the gastrointestinal odor cannot be improved, and the raw materials are in synthetic chemicals.

Eating bad breath also includes gum drinks, tea, candy, etc., but all are limited to removing oral bad breath.

As such, all of the above conventional bad breath agents are limited bad breath improvers limited to oral bad breath improvement.

Therefore, in order to get rid of bad breath caused by gastrointestinal, the medicine must be taken again.

The use of ash wood (Korea Patent Registration No. 10047647450000) has been reported to remove bad breath from the digestive organs (the stomach), but this applies only to the removal of the bad breath of the digestive organs (the stomach), which is again used to remove oral cause This should also be an economic and time-consuming inconvenience, because you have to use a bad breath remover,

Therefore, the natural anticorrosive properties of the present invention improve the bad breath of non-resistant, safe, economical and convenient new oral causes and gastrointestinal causes at the same time, and also with the bactericidal antibacterial effect of stomatitis 혓 needle caries gum disease sore throat tonsillitis cold oral disease There has been a great demand for bad breath improvers with a wide range of effects that are excellent and convenient for treatment and prevention.

In particular, many people suffering from difficulty in treating oral causative or gastrointestinal causal odor have been desperately required to have a convenient and easily improved odorant at the same time as the present invention.

In order to solve the above problems, the present invention is a natural anti-corrosive property, has no side effects and resistance, excellent antibacterial and antimicrobial effect of natural, excellent in improving gastrointestinal disorders

20-70% by weight of the grass and 10-35% by weight of tanza: sweetener and refreshing agent, 10-30% by weight of xylitol, 5-30% by weight of enzyme stevioside, 1-15% by weight of menthol, oral causes To provide a bad breath concurrent improver composition,

The main composition according to the present invention is a natural anti-corrosive property to the body, and can be easily swallowed after use by dissolving with saliva without water in the oral cavity conveniently, thereby improving oral cause and gastrointestinal cause at the same time, and stomatitis with the bactericidal antibacterial effect of the oral cavity Inflammatory tooth decay gum disease sore throat tonsillitis cold mouth disease

Oral cause and gastrointestinal cause removal agent composition of the present invention to achieve the above-mentioned object is specifically as follows, 20 to 70% by weight of heterozygous grass, preferably 38% by weight, 10 to 35% by weight of tanza preferably 25% %, Sweetening and cooling agent, xylitol 10-30% by weight, preferably 20% by weight, enzyme stevioside 5-30% by weight, preferably 13% by weight, menthol 1-15% by weight, preferably 4% by weight, composition do,

The composition may be prepared by methods well known in the art in addition to powder (powder), tablets, pills, capsules, liquids, and the like, and is not limited to the formulation,

The powder (powder) according to the above composition is preferably 0,2 g to 1 g once, preferably 0,5 g in the oral cavity with no saliva, and then the solution is rolled out of the tongue. You can swallow it,

Hereinafter, the present invention will be described in more detail with reference to the following examples. The following examples are not limited to the examples that illustrate the present invention.

Example 1

 Powder (powder)

Selected fresh, clean, non-polluted, domestically-grown heterogeneous tanks and sanitary washing with ultrasonic cleaner to remove residual harmful substances, and do not heat steam or heat extraction process to preserve the unique ingredients of herbal medicines. Each was finely powdered hygiene,

Foreign grass powder 38 g

Tanga powder 25 g

20 g of xylitol powder

Enzyme stevioside powder 13 g

4 g of menthol powder

The above ingredients were mixed and put back into the pulverizer to be mixed evenly, and repeatedly mixed, and sanitarily prepared using the powder (powder) agent according to the present invention according to the conventional powder (powder) preparation method.

Powder preparation prepared according to the above method is well preserved without destroying the intrinsic herbal components, and is excellent in efficacy in removing oral cause odor removal and gastrointestinal cause odor removal,

Powders can be used simply by dissolving them with saliva without water, or they can be used in a variety of ways, like tea.

[Example 2]

Test method and bad breath determination method

1.Selection of evaluation personnel

Seven well-trained evaluators, male and female, aged 25 to 40 years old, were selected.

2. Bad breath meter selection and bad breath measurement method:

A breath checker from the tanita company, a Japanese electronic digital breathalyzer with accurate breath test, was prepared.

Take the breath checker of the Japanese electronic digital breath tester tanita from Japan and take it in the morning, measure it at lunch, measure it at night, measure it before going to bed, and perform it 4 times a day. Measurement records,

3, judgment method:

Very bad and bad breath 5 Very bad breath 4 Severe bad breath 3 Slight bad breath 2

Very slight bad breath 1 Normal scored as 0,

4, Convenience:

Convenient and effective way to remove oral cause and gastrointestinal odor at the same time because it is carried as an anti-corrosive odorant of the present invention and is swallowed without spitting after use by dissolving with saliva without water anywhere in the place. To be rated as good G, bad N, good G, bad N

5, test method:

1) In the evaluation group trained in Comparative Test Example 1, the bad breath which occurred as usual was recorded according to the measurement judgment method.

2), To the well-trained evaluation group in Test Example 1, 0,5 g of the anti-corrosive micropowder (powder) deodorant of the present invention without water was dissolved only by saliva in the oral cavity, rolled out the tongue, and spreaded evenly between the entire mouth and teeth and gums. After buried, the solution was swallowed and consumed, preferably in the morning, in the lunch, in the evening, in between meals, before bed, 7 times a day.

After repeated use for 7 days, bad breath was measured and recorded according to the judgment method.

Example 3

Comparative Test Example 1 and Test Example 1

<Comparative Test Example 1>

The well-trained evaluation group first measured the bad breath in the usual bad breath occurrence state and recorded the score according to the judgment method is shown in Table 1 below,

  Table 1 Determination of Comparative Test Example 1 of Evaluation Group

Evaluation Agent Wake up in the morning Measurement at lunch Measure in the evening Measure before going to sleep convenience One 4 3 5 5 2 4 3 5 5 3 3 4 5 5 4 3 4 5 5 5 4 3 5 5 6 4 3 5 5 7 3 4 5 5 Sum 25 24 35 35

<Test Example 1>

To the well-trained evaluation group, carry the anti-corrosive micropowder bad breath of the present invention, and once in a mouth without water 0,5g dissolved in saliva only by saliva, rolled the dissolved solution evenly throughout the oral cavity between teeth and gums After burying the solution, the solution was swallowed. Thus, the bad breath removing agent of the present invention was used for 7 days each morning, lunch, dinner after meals, and between meals, 7 times each day, before going to bed, and the bad breath was measured according to the judgment method. The scores are shown in Table 2 below.

 Table 2 Determination of Test Example 1 of Evaluation Group

Evaluation Agent Wake up in the morning Measurement at lunch Measure in the evening Measure before going to sleep convenience One One 0 One One G 2 One One 0 0 G 3 0 0 0 One G 4 One 0 0 0 G 5 One One One One G 6 One 0 0 0 G 7 0 One One One G Sum 5 3 3 4 G

Table 3 shows the results of comparing the bad breath measurement score and the convenience judgment of Comparative Test Example 1 and Test Example 1,

[Table 3] Comparison table of the total score of judgment of Comparative Test Example 1 and Test Example 1

Comparative Test Example 1 Test Example 1 Convenience judgment Convenience judgment G Bad Breath Total Score 119 Bad Breath Total Score 15

※, in the simultaneous removal and convenience of oral cause and gastrointestinal cause odor, the anti-oral property oral cause and gastrointestinal cause odor removal agent of the present invention can be found to be excellent in convenience and excellent effect.

Examples of the formulations are given below, where the formulation examples are not limited thereto and are known to those skilled in the art.

[Example 1]

Tablet manufacturing:

500 mg of powder of Example 1

Lactose 100 mg

Starch 100 mg

The tablets are prepared by mixing the components and tableting according to a conventional tablet manufacturing method.

Preparation Example 2 Preparation of Pills

50 g of powder of Example 1

10 g of honey

Heat honey, filter, and repeat it again by rubbing by hand to make it viscous, yellow sand, and not sticky after cooling. The ingredients are mixed and kneaded to prepare a pill according to a conventional pill manufacturing method. You can also do it with syrup instead of honey.

Preparation Example 3 Preparation of Capsule

250 mg powder of Example 1

The above ingredients are filled into gelatin capsules according to a conventional capsule manufacturing method to prepare capsules.

[Example 4] Liquid Preparation:

38 g of crane

25 g of tanza

30 g of xylitol

20 g of enzyme steviosides

10 g of menthol

Trace amount

Purified water was multiplied to the composition constructed as described above, followed by stirring and heating at 90 to 100 ° C. for 2 hours according to a conventional liquid preparation method. The obtained solution was filtered, sealed and sealed in a sterile brown container to remove the bad breath of the present invention. To prepare a solution,

Claims (2)

Oral and gastrointestinal catheter improver composition consisting of 20 to 70% by weight of heterozygous and 10 to 35% by weight of tanza 10 to 30% by weight of xylitol, 5 to 30% by weight of enzyme stevioside, 1 to 15% by weight of menthol, The composition for improving oral and gastrointestinal odor, characterized in that the powder (powder), tablets, pills, or liquids, formulated as an active ingredient of the composition.