CN115177543B - Antibacterial caries preventing composition containing L-lactate, oral care product and preparation method and application thereof - Google Patents
Antibacterial caries preventing composition containing L-lactate, oral care product and preparation method and application thereof Download PDFInfo
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- CN115177543B CN115177543B CN202211057741.4A CN202211057741A CN115177543B CN 115177543 B CN115177543 B CN 115177543B CN 202211057741 A CN202211057741 A CN 202211057741A CN 115177543 B CN115177543 B CN 115177543B
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- lactate
- fluoride
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- antibacterial
- toothpaste
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- 239000000203 mixture Substances 0.000 title claims abstract description 83
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 title claims abstract description 82
- 229940116871 l-lactate Drugs 0.000 title claims abstract description 79
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 68
- 208000002925 dental caries Diseases 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title abstract description 16
- 238000004519 manufacturing process Methods 0.000 title description 7
- 239000000606 toothpaste Substances 0.000 claims abstract description 72
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims abstract description 70
- 229940034610 toothpaste Drugs 0.000 claims abstract description 63
- 230000000675 anti-caries Effects 0.000 claims abstract description 28
- 229940091249 fluoride supplement Drugs 0.000 claims description 78
- 239000003906 humectant Substances 0.000 claims description 41
- 239000011259 mixed solution Substances 0.000 claims description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims description 17
- 229920001223 polyethylene glycol Polymers 0.000 claims description 17
- 239000002562 thickening agent Substances 0.000 claims description 17
- 239000004094 surface-active agent Substances 0.000 claims description 15
- 235000003599 food sweetener Nutrition 0.000 claims description 14
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 14
- 239000003765 sweetening agent Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000000600 sorbitol Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 10
- MKJXYGKVIBWPFZ-CEOVSRFSSA-L calcium;(2s)-2-hydroxypropanoate Chemical compound [Ca+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O MKJXYGKVIBWPFZ-CEOVSRFSSA-L 0.000 claims description 8
- NGSFWBMYFKHRBD-DKWTVANSSA-M sodium;(2s)-2-hydroxypropanoate Chemical compound [Na+].C[C@H](O)C([O-])=O NGSFWBMYFKHRBD-DKWTVANSSA-M 0.000 claims description 8
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 7
- 239000011775 sodium fluoride Substances 0.000 claims description 7
- 235000013024 sodium fluoride Nutrition 0.000 claims description 7
- 229960000414 sodium fluoride Drugs 0.000 claims description 7
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 7
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 7
- 229960002799 stannous fluoride Drugs 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 239000004909 Moisturizer Substances 0.000 claims description 6
- 230000001333 moisturizer Effects 0.000 claims description 6
- PHZLMBHDXVLRIX-DKWTVANSSA-M potassium;(2s)-2-hydroxypropanoate Chemical compound [K+].C[C@H](O)C([O-])=O PHZLMBHDXVLRIX-DKWTVANSSA-M 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 230000003385 bacteriostatic effect Effects 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 238000007872 degassing Methods 0.000 claims description 4
- DEQJBORXLQWRGV-UHFFFAOYSA-N 2-hydroxypropanoic acid;iron Chemical compound [Fe].CC(O)C(O)=O.CC(O)C(O)=O DEQJBORXLQWRGV-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 239000002280 amphoteric surfactant Substances 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 239000003945 anionic surfactant Substances 0.000 claims description 3
- 229960003563 calcium carbonate Drugs 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 239000000679 carrageenan Substances 0.000 claims description 3
- 235000010418 carrageenan Nutrition 0.000 claims description 3
- 229920001525 carrageenan Polymers 0.000 claims description 3
- 229940113118 carrageenan Drugs 0.000 claims description 3
- 125000002091 cationic group Chemical group 0.000 claims description 3
- 239000003093 cationic surfactant Substances 0.000 claims description 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 3
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims description 3
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 3
- 229960004029 silicic acid Drugs 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 3
- 235000019408 sucralose Nutrition 0.000 claims description 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 3
- 230000008961 swelling Effects 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
- 239000004135 Bone phosphate Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 150000003895 L-lactate salts Chemical class 0.000 claims 6
- 230000000694 effects Effects 0.000 abstract description 26
- -1 fluoride ions Chemical class 0.000 abstract description 25
- 210000000214 mouth Anatomy 0.000 abstract description 18
- 230000002195 synergetic effect Effects 0.000 abstract description 15
- 239000011737 fluorine Substances 0.000 abstract description 10
- 229910052731 fluorine Inorganic materials 0.000 abstract description 10
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract description 5
- 238000001179 sorption measurement Methods 0.000 abstract description 3
- 230000001680 brushing effect Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 28
- 241000894006 Bacteria Species 0.000 description 27
- 239000006072 paste Substances 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
- 230000002401 inhibitory effect Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 238000009472 formulation Methods 0.000 description 9
- 239000013588 oral product Substances 0.000 description 9
- 229940001447 lactate Drugs 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 235000015218 chewing gum Nutrition 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- 241000194019 Streptococcus mutans Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 229940112822 chewing gum Drugs 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 229940051866 mouthwash Drugs 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 4
- 241000605862 Porphyromonas gingivalis Species 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000004225 ferrous lactate Substances 0.000 description 4
- 229940037907 ferrous lactate Drugs 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 208000028169 periodontal disease Diseases 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000000170 anti-cariogenic effect Effects 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 206010018276 Gingival bleeding Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 230000001013 cariogenic effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 206010061291 Mineral deficiency Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 238000002814 agar dilution Methods 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000000214 effect on organisms Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940023486 oral product Drugs 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 229960003010 sodium sulfate Drugs 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to the technical field of oral care products, in particular to an antibacterial caries-preventing composition containing L-lactate, an oral care product, a preparation method and application thereof. The antibacterial and anticarious composition comprises two components of L-lactate and fluoride, wherein the L-lactate and the fluoride are applied to the preparation of oral care products according to a certain proportion, a synergistic phenomenon is shown on antibacterial effect, and the technical problem of further improving the anticarious effect of fluorine-containing toothpaste is solved. The composition is applied to oral care products including toothpaste, and can promote the enrichment of fluoride ions and strengthen the antibacterial and anticaries effects of the fluoride ions by utilizing the stronger biological adsorptivity of the L-lactate and the adsorption effect of the L-lactate on the fluoride ions through operations such as tooth brushing, gargling and the like. The oral care composition containing the composition disclosed by the invention not only can help a user to clean the oral cavity effectively, but also has the enhanced effect of preventing dental caries, and has a good application prospect.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to an antibacterial caries-preventing composition containing L-lactate, an oral care product, a preparation method and application thereof.
Background
The discovery of fluoride anticarious is known as one of the biggest contributions of oral preventive medicine in the 20 th century to humans. Many studies have been made on the mechanism of anticaries action of fluoride, and the main mechanism of action has three points. First, fluoride ions, when present in the oral environment, may promote remineralization of early caries lesions by eating, drinking, or the application of fluoride preparations, etc. The apatite can be promoted to be deposited on the enamel surface, and the decalcified caries tooth surface is calcified again, so that the restoration process can be started before caries is formed, and the method is considered to be a main action mechanism. Second, fluoride ions can act directly on the plaque, reducing the acid producing capacity of bacteria within the plaque. When fluoride enters the plaque, such minerals interfere with and destroy the bacteria's various enzymes used to metabolize sugar, thus reducing the bacteria's ability to produce acid. Third, when fluoride ions are present in saliva, it is mixed with saliva and bacteria, which, due to their ability to inhibit the absorption of sugar by bacteria in the plaque, deprive the bacteria of its main nutrient source and consequently reduce or eliminate the acid production by the bacteria.
Fluoride is anticarious by inhibiting the growth and reproduction of cariogenic bacteria and slowing down the rate of acid production. The main cariogenic bacteria of the teeth are particularly sensitive to fluorine, and can generate bacterial mutation or adaptation change after contacting with fluorine, and even can cause the generation of antibacterial bacteria, thereby changing the micro-ecological environment of the bacteria. Although the fluorine-containing oral care products in the prior art are five-flower eight doors, how to improve the anti-caries effect of fluoride and the utilization rate of fluoride is still a problem to be solved in the field of oral care products.
Disclosure of Invention
The invention aims to provide an antibacterial caries-preventing composition containing L-lactate, which aims to solve the technical problem of further improving the caries-preventing effect of fluorine-containing toothpaste. The technical scheme effectively combines L-lactate and fluoride and is used in the oral appliance, the characteristics of the two components are utilized for combined addition, and experiments prove that the beneficial effects of the oral appliance are achieved, the synergistically enhanced antibacterial caries-preventing composition components are obtained, a user is helped to effectively clean the oral cavity, dental caries is prevented, and symptoms such as gingival bleeding are relieved.
In order to achieve the above purpose, the invention adopts the following technical scheme:
an antibacterial anticaries composition containing L-lactate comprises L-lactate and fluoride.
The present solution also provides an oral care product comprising an antibacterial anticaries composition comprising L-lactate, the oral care product comprising a toothpaste, a liquid toothpaste, a mouthwash, a dentifrice, a tooth gel, and a chewing gum.
The principle of the technical scheme and the beneficial effects are that:
the oral composition containing the L-lactate provided by the invention is added by utilizing the characteristics of the L-lactate and fluoride, and has the beneficial effects of obtaining the antibacterial and anticariogenic composition components capable of achieving synergistic reinforcement through experimental verification, helping a user to effectively clean the oral cavity, and solving the symptoms of gingival bleeding, halitosis, caries prevention and the like. The L-lactate and the fluoride are simultaneously used in the preparation of the oral cleaning product, so that the ideal antibacterial and anticaries effects can be obtained, and the action effect of the fluoride is further improved. Particularly in actual oral care operations (e.g., brushing with toothpaste). The inventors analyzed the reason for: the L-lactate can be effectively adhered to the oral mucosa or the tooth surface, and carboxyl ions contained in the lactate ions can form intermolecular hydrogen bonds with fluorine ions, so that the adsorption force on the fluorine ions is increased, and the fluorine ions are strengthened to play a role in inhibiting bacteria and preventing caries.
In this technical scheme, both L-lactate and fluoride are used. L-lactate is a derivative of L-lactic acid, which is formed by losing a proton from a carboxyl group in an L-lactic acid molecule to a carboxylate ion, and has been widely used in the field of daily chemicals. L-lactate has good biocompatibility due to the characteristic of levorotatory, can be fused with mammals, can directly participate in human metabolism, has no side effect, and is widely applied to the fields of food, medicine and the like. L-lactate components such as L-calcium lactate, L-sodium lactate, L-potassium lactate, L-ferrous lactate and the like have antibacterial and anti-tartar effects in oral care products, and have positive effects on inhibiting gingivitis. In addition, the L-lactate has high bioavailability, good taste, neutral pH value and high solubility, and is a good mineral fortifier for corresponding mineral deficiency.
Because the L-lactate has the functions of antioxidation and bacteriostasis, the L-lactate can effectively inhibit periodontal gingivitis; fluoride is used as an industry-accepted anticarious agent, the anticarious effect of which can be influenced by the pH value, and the fluoride can exert better anticarious effect only in weak acid environment. The inventor originally aims to utilize the advantages of two substances, namely, the two substances are added into an oral care product at the same time, and unexpectedly, the two substances have the synergistic effect on the effect of inhibiting common bacteria in the oral environment besides the antioxidant, antibacterial and anticaries effects of the two substances. The inventor then carries out a large number of antibacterial tests, and verifies that the combined use of the L-lactate and the fluoride has a synergistic phenomenon, and the antibacterial effect of the antibacterial caries-preventing composition is obviously improved compared with that of the single use of the L-lactate and the single use of the fluoride. The inventor analyzes that the mechanism of the synergistic effect of two substances is as follows: the L-lactate has better adsorption effect on organisms, and lactate ions in the L-lactate can form intermolecular hydrogen bonds with fluorine ions, so that the solubility and bioavailability of the fluorine ions are increased, and the antibacterial effect is further improved. Especially in the process of cleaning the oral cavity, the L-lactate has better adsorptivity to biological films (oral mucosa, biological films formed by oral bacteria and the like), and the L-lactate has antibacterial effect, so that the oral environment can be effectively changed. And secondly, lactate ions in the L-lactate can form intermolecular hydrogen bonds with fluoride ions, so that the solubility of the fluoride ions and the adhesion of the fluoride ions on the teeth and other parts are increased, and the anticaries effect of the fluoride ions on the oral cavity is improved.
The inventors further applied a bacteriostatic anticaries composition consisting of L-lactate and fluoride in toothpaste, liquid toothpaste, mouthwash, dentifrice, tooth gel or chewing gum. In the using process, the two substances are synergistic, so that the inhibition of oral bacteria can be realized. The antibacterial and anticarious composition has multiple protection effects on the oral cavity and can inhibit the breeding of streptococcus mutans. And because the related oral pathogenic bacteria are inhibited, the antibacterial and anticariogenic composition also has certain potential for preventing and treating caries and periodontal disease.
In summary, the antibacterial anticarious composition composed of L-lactate and fluoride has the beneficial effects that:
(1) L-lactate, because of its levorotatory characteristic, has very good biocompatibility, can be absorbed on the surface of biomembrane well, melt with mammal, can participate in human metabolism directly, have certain antibacterial effect, can play a synergistic effect with antimicrobial agent, add in the nursing product of oral cavity, can play the role of inhibiting oral bacteria effectively.
(2) Fluoride is often provided by oral care products, but its effectiveness is limited. The oral composition containing the L-lactate can be effectively adhered to the surfaces of oral mucosa or teeth, and lactate ions in the L-lactate can form hydrogen bonds with fluoride ions, so that the adhesion of the fluoride ions to the oral cavity can be increased, and the antibacterial and anticaries effects of the fluoride ions are enhanced.
(3) The L-lactate and fluoride are compounded and applied to other oral products such as toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel, chewing gum and the like, so that the oral care product has multiple protection effects on the oral cavity and improves the antibacterial caries prevention effect of the oral care product.
Further, the weight percentage of fluoride is 20-99.9%, and the rest is L-lactate. By adopting the proportion, the L-lactate and the fluoride can fully play the roles of resisting bacteria and preventing decayed teeth.
Further, the L-lactate includes at least one of sodium L-lactate, potassium L-lactate, calcium L-lactate and ferrous L-lactate. Experiments prove that the L-lactate can realize the synergistic effect with fluoride, and the lactate is more common and easy to obtain.
Further, the fluoride includes at least one of sodium fluoride, stannous fluoride, and sodium monofluorophosphate. The fluoride is commonly used in oral care products, is easy to obtain and has stable properties.
Further, the oral care product comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 10-70 parts of humectant, 0-60 parts of friction agent, 0.1-10 parts of thickening agent, 0.1-20 parts of surfactant, 0.1-2 parts of sweetener and 0.1-5 parts of essence. The antibacterial and anticaries composition composed of fluoride and L-lactate can be added into oral care products to clean the oral cavity and realize antibacterial and anticaries effects. According to the above formula, proper raw material dosage is selected, and the product such as toothpaste, liquid toothpaste, mouthwash, dentifrice, tooth gel, chewing gum and the like can be prepared.
Further, the oral care product comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 20-60 parts of humectant, 10-50 parts of friction agent, 0.5-3 parts of thickening agent, 0.1-5 parts of surfactant, 0.1-0.5 part of sweetener and 0.1-2 parts of essence. The formula is used for preparing toothpaste, the toothpaste is the most common oral cavity cleaning product with the highest use frequency, and the antibacterial and anticaries composition is added into the toothpaste, so that the use frequency of the antibacterial and anticaries composition can be increased, and better effects of inhibiting oral bacteria and preventing caries are obtained.
Further, the moisturizer includes a first moisturizer and a second moisturizer; the first humectant comprises at least one of glycerin, sorbitol, and propylene glycol; the second humectant is polyethylene glycol.
By adopting the technical scheme, the glycerol, the sorbitol and the propylene glycol are humectants which can be used in toothpaste, and the humectants are required to be matched with polyethylene glycol for use so as to ensure the stability of the toothpaste. Among them, sorbitol can most effectively maintain paste stability and increase antibacterial effect of toothpaste in the system containing L-lactate and fluoride in the scheme.
Further, the abrasive comprises at least one of calcium carbonate, hydrated silica, dibasic calcium phosphate, and tribasic calcium pyrophosphate; the thickener comprises at least one of hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate and carbomer; the surfactant includes at least one of anionic, cationic, amphoteric and nonionic surfactants; the sweetener comprises at least one of sodium saccharin and sucralose. The friction agent, the surfactant and the like are commonly used in the prior art, and have the advantages of good safety and stability, low price and easy acquisition.
The technical scheme also provides a preparation method of the oral care product, which comprises the following steps in sequence:
s1: dispersing a thickening agent in polyethylene glycol, adding a first humectant, and fully swelling to form a mixed solution A;
s2: fully mixing fluoride and L-lactate, and dissolving with water to form a mixed solution B;
s3: adding sweetener, surfactant and water into the mixed solution A, and homogenizing to obtain mixed solution C;
s4: fully stirring the mixed solution C and the mixed solution B to form a mixed material D;
s5: adding a friction agent into the mixture D, and fully and uniformly mixing to obtain a mixture E;
s6: adding essence into the mixture E, homogenizing, and degassing to obtain the product.
The principle of adopting the scheme and the beneficial effects are that:
the preparation method is suitable for preparing toothpaste. In the preparation process, the thickener and the polyethylene glycol are fully dispersed, and then the rest humectant is added for dispersion swelling, so that the toothpaste (represented by oral care products) forms a stable framework structure. And secondly, fully contacting and mixing the L-lactate and the fluoride, and fully dissolving the L-lactate and the fluoride by using water, so that the L-lactate and the fluoride can be fully contacted, and the effect of the L-lactate and the fluoride on caries resistance, bacteria inhibition and the like is improved. The other ingredients are added after final mixing, so that the preparation process ensures the stability of the toothpaste (represented by oral care products) and the efficacy of both the L-lactate and fluoride.
In addition to toothpastes, the compositions of the present embodiments may also be used in the preparation of other oral cleaning products such as liquid toothpastes, mouthwashes, tooth powders, tooth gels, and chewing gums. The L-lactate and fluoride forming composition may be added to the corresponding product by conventional means in the art.
Detailed Description
The present invention will be described in further detail with reference to examples, but embodiments of the present invention are not limited thereto. Unless otherwise indicated, the technical means used in the following examples and experimental examples are conventional means well known to those skilled in the art, and the materials, reagents and the like used are all commercially available.
The scheme is as follows:
(1) Composition and method for producing the same
The antibacterial and anticaries composition for oral cavity consists of fluoride in 20-99.9 wt% and L-lactate in the rest. The fluoride is one or more of sodium fluoride, sodium monofluorophosphate and stannous fluoride.
Both the above-mentioned L-lactate and fluoride are commercially available from suppliers. Wherein, L-sodium lactate, L-potassium lactate, L-ferrous lactate and L-calcium lactate are purchased from Zhengzhou Aipu bioengineering Co., ltd. Fluorides (including sodium fluoride, stannous fluoride, sodium monofluorophosphate, etc.) are purchased from Hubei Xingfu chemical company, inc., cosmetic grade.
(2) Toothpaste prepared from the composition
Toothpaste containing antibacterial and anticaries composition comprises the antibacterial and anticaries composition, an abrasive, a thickener, a humectant, a sweetener, a surfactant, other effective components, essence and water. The weight portions of the components are as follows: 0.1-2.0 parts of fluoride, 0.1-1.0 parts of L-lactate, 10-70 parts of humectant, 0-60 parts of friction agent, 0.1-10 parts of thickening agent, 0.1-20 parts of surfactant, 0.1-2 parts of sweetener and 0.1-5 parts of essence.
The purity of the fluoride is more than or equal to 99.5%; the purity of the L-lactate is more than or equal to 99.5%; the water is purified water. The fluoride comprises at least one of sodium fluoride, stannous fluoride and sodium monofluorophosphate; the L-lactate includes at least one of L-calcium lactate, L-ferrous lactate, L-sodium lactate and L-potassium lactate.
The content of the humectant is preferably 20-60 parts, including at least one of glycerin, sorbitol, propylene glycol (first humectant) and polyethylene glycol (second humectant), and the first humectant is preferably glycerin. The mass ratio of the first humectant to the second humectant is 5-50:1-10, more preferably 40-50:10.
the content of the abrasive is preferably in the range of 10 to 50 parts, including at least one of calcium carbonate, hydrated silica, dibasic calcium phosphate and calcium pyrophosphate.
The content of the thickener is preferably in the range of 0.5 to 3 parts, including at least one of hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate and carbomer.
The content of the surfactant is preferably in the range of 0.1 to 5 parts, including at least one of anionic, cationic, amphoteric and nonionic surfactants, such as sodium dodecyl sulfate, sodium lauroyl sarcosinate, sodium sulfate or cocamidopropyl betaine, etc.
The content of the sweetener is preferably in the range of 0.1 to 0.5 parts, including at least one of sodium saccharin and sucralose.
The essence content is preferably 0.1-2 parts, including at least one of herba Menthae, oleum Sesami, peppermint, and anethole.
The preparation method of the toothpaste comprises the following steps:
s1: mixing and fully dispersing the thickener and polyethylene glycol (second humectant), and adding the rest humectant (first humectant) to fully swell to form a mixed solution A.
S2: the fluoride and lactate are thoroughly mixed and then dissolved in 10-15% by mass of water to form a mixed solution B (for convenience of comparison, 10% of water is uniformly used in the examples and comparative examples).
S3: and adding sweetener, surfactant and the rest of water into the mixed solution A, and homogenizing to obtain a mixed solution C.
S4: the mixture C and the mixture B are sufficiently stirred to form a mixture D.
S5: adding a friction agent into the mixture D, and fully and uniformly mixing to obtain a mixture E;
s6: adding essence into the mixture E, homogenizing, degassing to obtain product, and filling into toothpaste tube in conventional manner.
Examples 1-6 show the composition of antibacterial anticaries compositions, specifically as follows:
example 1: antibacterial and anticarious composition for oral products
The antibacterial caries preventing composition for the oral cavity articles consists of the following components in percentage by weight: 20% of sodium fluoride and 80% of sodium L-lactate.
Example 2: antibacterial and anticarious composition for oral products
The antibacterial caries preventing composition for the oral cavity articles consists of the following components in percentage by weight: 30% of stannous fluoride and 70% of L-calcium lactate.
Example 3: antibacterial and anticarious composition for oral products
The antibacterial caries preventing composition for the oral cavity articles consists of the following components in percentage by weight: 40% sodium monofluorophosphate, 60% potassium L-lactate
Example 4: antibacterial and anticarious composition for oral products
The antibacterial caries preventing composition for the oral cavity articles consists of the following components in percentage by weight: 99.9% of sodium fluoride and 0.1% of L-ferrous lactate.
Example 5: antibacterial and anticarious composition for oral products
The antibacterial caries preventing composition for the oral cavity articles consists of the following components in percentage by weight: 25% of stannous fluoride and 75% of sodium L-lactate.
Example 6: antibacterial and anticarious composition for oral products
The antibacterial caries preventing composition for the oral cavity articles consists of the following components in percentage by weight: 30% of sodium monofluorophosphate and 70% of L-calcium lactate.
Examples 7-16 illustrate the procedure for obtaining a toothpaste containing a bacteriostatic anticaries composition, the toothpaste formulation being specifically identified in table 1. When the total mass part of the toothpaste is 100 parts and the sum of other toothpaste raw materials is less than 100 parts, the rest is supplemented with water.
Table 1: antibacterial anticarious toothpaste formula (unit: mass portion)
Experimental example 1: bacteriostasis test
To verify the bacteriostatic effect of the toothpastes of the present invention, toothpastes without L-lactate and with fluoride only (group 2 in Table 2), as well as toothpastes with L-lactate and fluoride (group 4 in Table 2), and the comparison of the two toothpastes (group 1 and group 3 in Table 2) were prepared, and the specific formulations are shown in Table 2.
Table 2: toothpaste formula table (100 parts of total mass)
The four toothpaste sets shown in Table 2 were mixed and dissolved in agar culture according to minimum inhibitory concentration test method of disinfection technical Specification-2.1.8.3, 2002 edition of Ministry of health, by agar dilution method, and then tested bacteria were grown on o' clock, and the minimum inhibitory concentration of antibacterial substances for inhibiting the growth of the tested bacteria was determined by determining whether the bacteria were grown or not, and finally the results were shown in tables 3 to 7.
Table 3: MIC test results with sodium L-lactate and/or fluoride
Table 4: MIC test results with L-calcium lactate and/or fluoride
Table 5: MIC test results with ferrous L-lactate and/or fluoride
Table 6: MIC test results with Potassium and/or fluoride L-lactate
As shown in the antibacterial test results of tables 3-6, the Minimum Inhibitory Concentration (MIC) obtained by the experiments of the groups 2 and 3 has obvious antibacterial advantages compared with the blank control of the group 1. Compared with the groups 2 and 3, the group 4 in the tables 3-6 has better effects of inhibiting streptococcus mutans and porphyromonas gingivalis, and the fact that the L-lactate and the fluoride are added simultaneously has the synergistic effect of enhancing the antibacterial effect is proved. Among them, streptococcus mutans is a major caries-causing pest and Porphyromonas gingivalis is a major periodontal disease-causing pest. Because the composition of the scheme can effectively inhibit caries and periodontal disease related bacteria, the antibacterial and anticariogenic composition also has certain potential for preventing and treating caries and periodontal disease.
The antibacterial and anticaries composition of the present invention is not only used in toothpaste, which is an oral product, but also is suitable for other oral products such as liquid toothpaste, mouthwash, tooth powder, tooth gel, chewing gum, etc.
Comparative example 1: effect of humectant on bacteriostasis and paste stability
The preparation method of the comparative example 1, groups 1 to 5, was basically the same as that of example 8, except for the difference in formulation, and the formulation of the comparative example is shown in Table 7. In addition, since the group 3 to 5 does not contain polyethylene glycol, the first humectant-dispersed thickener is directly used in S1 to form the mixed liquid a.
Table 7: comparative example 1, 1-5 group formulation set (parts by weight)
The minimum concentration (MIC) of the anti (bacteriostatic) substances of example 8, the 1, 2, 3, 4 and 5 groups of comparative example 1, which inhibited the growth of the test bacteria, was examined by referring to the method of experimental example 1 as follows (table 8):
table 8: MIC test results of 1-5 groups of comparative example 1
From the above experimental results, it can be seen that: in example 8, 0.5 parts by weight of fluoride was used together with 0.1 parts by weight of L-lactate to prepare a toothpaste, and the obtained toothpaste paste showed a relatively ideal antibacterial effect against Streptococcus mutans and Porphyromonas gingivalis. The difference between the groups 1 and 2 and the example 8 is that the replacement of the first humectant sorbitol with glycerin or propylene glycol reduced the antibacterial effect of the obtained toothpaste by 5 times. This demonstrates that the selection of the appropriate humectant plays a very significant role in the synergistic effect of fluoride and L-lactate. The difference between group 4 and example 8 is: polyethylene glycol is not selected as the second humectant, and the thickening agent is not dispersed first by using polyethylene glycol, so that the obtained toothpaste has a poor antibacterial effect. The difference between group 3 and example 8 is: polyethylene glycol is not selected as the second humectant, sorbitol is not selected as the first humectant, and the obtained toothpaste has a poor antibacterial effect. The experimental results of groups 3 and 4 show that the addition of polyethylene glycol and the combination of sorbitol play an important role in the synergistic effect of fluoride and L-lactate. In the group 5, only sorbitol is used as the humectant, and other types of humectants are not compounded, so that the synergistic effect of fluoride and L-lactate is not exerted. In combination, although fluoride and L-lactate show some synergy, other ingredients in the toothpaste formulation can also have an impact on whether the synergy can be demonstrated. The combination of sorbitol and polyethylene glycol humectants can maximize the synergistic effect between fluoride and L-lactate. The inventors analyzed that the reason is that L-lactate has the best effect of binding and enriching fluoride and the best effect of attaching L-lactate to bacteria in a toothpaste formulation containing a certain amount of sorbitol and polyethylene glycol, and can enhance the inhibition of both substances to bacteria.
In addition, the inventors have observed the stability of toothpastes according to GB/T8372-2017. 2 samples of toothpaste are taken from each group, 1 sample is stored at room temperature, the other sample is put into a refrigerator at-8+/-1 ℃ for 8 hours and then is taken out, then is put into a constant temperature incubator at 45+/-1 ℃ for 8 hours, and is taken out, the room temperature is restored, and then the stability observation is carried out. For the toothpaste of example 8, after uncapping, the paste did not overflow the nozzle; inverting the toothpaste tube body, wherein no liquid drips out from the tube opening within 10 seconds; the paste is extruded and compared with a sample stored at room temperature, the paste has normal fragrance and color, and the surface of the toothpaste is glossy. For the toothpastes of groups 1 to 5 of this comparative example, the surfaces of the toothpastes of groups 1 and 2 were not glossy but did not affect the use. The tail part and the head part of the paste are respectively separated from each other in the 3 groups, the 4 groups and the 5 groups, namely, the solid phase and the liquid phase are separated, and the paste is unstable. In toothpaste containing L-lactate, fluoride and other components, the humectant is very important to maintain the stability of the paste, and the combination of sorbitol and polyethylene glycol can ensure the stability of the paste to the greatest extent.
The experimental results show that the selection of the proper humectant is very important for maintaining the stability of the toothpaste body containing the L-lactate, and the proper humectant ensures that the L-lactate and the fluoride can produce ideal synergistic effect.
Comparative example 2: influence of the manufacturing Process on the stability of the paste
This comparative example 2 is basically the same as example 8, except that the toothpaste is prepared as follows:
the preparation method of the toothpaste comprises the following steps:
s1: mixing and fully dispersing the thickener and polyethylene glycol (second humectant), and adding the rest humectant (first humectant) to fully swell to form a mixed solution A.
S2: and adding fluoride and lactate into the mixed solution A, and homogenizing to obtain a mixed solution A'.
S3: and adding sweetener, surfactant and water into the mixed solution A', and homogenizing to obtain a mixture C.
S4: adding a friction agent into the mixture C, and fully and uniformly mixing to obtain a mixture D;
s5: adding essence into the mixture D, homogenizing, degassing to obtain the product, and filling into toothpaste tube in conventional manner.
The stability of the toothpaste of comparative example 2 was observed in accordance with GB/T8372-2017, and the development of inverting the toothpaste tube out of the water appeared. The toothpaste is found to be water-divided when the toothpaste is cut, and the rough surface of the toothpaste affects the use. The above experiments demonstrate that when using the formulation of the present embodiment to prepare toothpaste, an appropriate manufacturing process is important for maintaining the stability of the paste. The humectant and the thickener are mixed firstly, then the mixture is mixed with the sweetener, the surfactant and the like, and then the fluoride and the lactate in a solution state are added, so that the paste prepared by the method has better stability. The minimum concentration (MIC) of the antibacterial substance of this comparative example 2, which inhibits the growth of the test bacteria, was detected by referring to the method of experimental example 1 as follows: streptococcus mutans 2X 10 3 Mu g/ml, porphyromonas gingivalis 2X 10 3 μg/ml。
The above results demonstrate that the synergistic effect of L-lactate and fluoride is exerted and that the maintenance of paste stability under the present formulation requires a specific preparation process to be ensured.
The foregoing is merely exemplary of the present invention, and specific technical solutions and/or features that are well known in the art have not been described in detail herein. It should be noted that, for those skilled in the art, several variations and modifications can be made without departing from the technical solution of the present invention, and these should also be regarded as the protection scope of the present invention, which does not affect the effect of the implementation of the present invention and the practical applicability of the patent. The protection scope of the present application shall be subject to the content of the claims, and the description of the specific embodiments and the like in the specification can be used for explaining the content of the claims.
Claims (7)
1. A toothpaste comprising an L-lactate salt antibacterial anticaries composition, characterized in that: it comprises a bacteriostatic caries-preventing composition and a humectant;
the antibacterial anticaries composition comprises L-lactate and fluoride; the weight percentage of fluoride is 20-99.9%, and the rest components are L-lactate;
the moisturizer comprises a first moisturizer and a second moisturizer; the first humectant is sorbitol; the second humectant is polyethylene glycol.
2. A toothpaste comprising an L-lactate salt-containing antibacterial anticaries composition according to claim 1, wherein: the L-lactate includes at least one of sodium L-lactate, potassium L-lactate, calcium L-lactate and ferrous L-lactate.
3. A toothpaste comprising an L-lactate salt-containing antibacterial anticaries composition according to claim 1, wherein: the fluoride includes at least one of sodium fluoride, stannous fluoride, and sodium monofluorophosphate.
4. A toothpaste comprising an L-lactate salt-containing antibacterial anticaries composition according to any one of claims 1-3, wherein: the material comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 10-70 parts of humectant, 0-60 parts of friction agent, 0.1-10 parts of thickening agent, 0.1-20 parts of surfactant, 0.1-2 parts of sweetener and 0.1-5 parts of essence.
5. The toothpaste containing an L-lactate salt-containing antibacterial anticaries composition according to claim 4, wherein: the material comprises the following raw materials in parts by weight: 0.1-2 parts of fluoride, 0.1-1 part of L-lactate, 20-60 parts of humectant, 10-50 parts of friction agent, 0.5-3 parts of thickening agent, 0.1-5 parts of surfactant, 0.1-0.5 part of sweetener and 0.1-2 parts of essence.
6. The toothpaste comprising an L-lactate salt-containing antibacterial anticaries composition according to claim 5, wherein the abrasive comprises at least one of calcium carbonate, hydrated silica, dibasic calcium phosphate, and tribasic calcium pyrophosphate; the thickener comprises at least one of hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate and carbomer; the surfactant includes at least one of anionic, cationic, amphoteric and nonionic surfactants; the sweetener comprises at least one of sodium saccharin and sucralose.
7. The method for preparing the toothpaste containing the antibacterial and anticaries composition of L-lactate according to claim 6, wherein the method comprises the following steps: the method comprises the following steps of:
s1: dispersing a thickening agent in polyethylene glycol, adding a first humectant, and fully swelling to form a mixed solution A;
s2: fully mixing fluoride and L-lactate, and dissolving with water to form a mixed solution B;
s3: adding sweetener, surfactant and water into the mixed solution A, and homogenizing to obtain mixed solution C;
s4: fully stirring the mixed solution C and the mixed solution B to form a mixed material D;
s5: adding a friction agent into the mixture D, and fully and uniformly mixing to obtain a mixture E;
s6: adding essence into the mixture E, homogenizing, and degassing to obtain the product.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101119702A (en) * | 2004-12-21 | 2008-02-06 | 高露洁-棕榄公司 | Anti-caries oral care composition with a chelating agent |
| CN101123939A (en) * | 2004-12-21 | 2008-02-13 | 高露洁-棕榄公司 | Anti-caries oral care composition with xylitol |
| CN108514528A (en) * | 2018-06-22 | 2018-09-11 | 中山遇美生物科技有限公司 | A kind of Pediatric Oral Emergency nursing tooth liquid and preparation method thereof |
| CN108785115A (en) * | 2018-06-22 | 2018-11-13 | 中山遇美生物科技有限公司 | A kind of teenagers growth phase oral care tooth liquid and preparation method thereof |
| CN110859765A (en) * | 2019-12-17 | 2020-03-06 | 北京天一恒康医疗器械有限公司 | Fluorinated foam for preventing dental caries |
| CN112494349A (en) * | 2020-12-17 | 2021-03-16 | 浙江甬誉生物科技有限公司 | Oral care composition with anti-sensitivity, gum repairing and antibacterial effects |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070025928A1 (en) * | 1999-11-12 | 2007-02-01 | The Procter & Gamble Company | Stannous oral care compositions |
| JP2023542025A (en) * | 2020-09-28 | 2023-10-04 | ザ プロクター アンド ギャンブル カンパニー | An array of anti-cavity oral care compositions |
-
2022
- 2022-08-31 CN CN202211057741.4A patent/CN115177543B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101119702A (en) * | 2004-12-21 | 2008-02-06 | 高露洁-棕榄公司 | Anti-caries oral care composition with a chelating agent |
| CN101123939A (en) * | 2004-12-21 | 2008-02-13 | 高露洁-棕榄公司 | Anti-caries oral care composition with xylitol |
| CN108514528A (en) * | 2018-06-22 | 2018-09-11 | 中山遇美生物科技有限公司 | A kind of Pediatric Oral Emergency nursing tooth liquid and preparation method thereof |
| CN108785115A (en) * | 2018-06-22 | 2018-11-13 | 中山遇美生物科技有限公司 | A kind of teenagers growth phase oral care tooth liquid and preparation method thereof |
| CN110859765A (en) * | 2019-12-17 | 2020-03-06 | 北京天一恒康医疗器械有限公司 | Fluorinated foam for preventing dental caries |
| CN112494349A (en) * | 2020-12-17 | 2021-03-16 | 浙江甬誉生物科技有限公司 | Oral care composition with anti-sensitivity, gum repairing and antibacterial effects |
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