CN112691045A - Antibacterial toothpaste and preparation method thereof - Google Patents

Antibacterial toothpaste and preparation method thereof Download PDF

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Publication number
CN112691045A
CN112691045A CN202110167631.2A CN202110167631A CN112691045A CN 112691045 A CN112691045 A CN 112691045A CN 202110167631 A CN202110167631 A CN 202110167631A CN 112691045 A CN112691045 A CN 112691045A
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China
Prior art keywords
mixture
uniformly mixing
toothpaste
sodium bicarbonate
antibacterial toothpaste
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Pending
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CN202110167631.2A
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Chinese (zh)
Inventor
周正涵
周静
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Individual
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Individual
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Priority to CN202110167631.2A priority Critical patent/CN112691045A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24Phosphorous; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/738Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41Particular ingredients further characterized by their size
    • A61K2800/413Nanosized, i.e. having sizes below 100 nm

Abstract

The invention relates to an antibacterial toothpaste and a preparation method thereof, wherein the antibacterial toothpaste comprises 5.70-21.14% of sodium bicarbonate, 32.20-69.10% of calcium hydrogen phosphate dihydrate, 1.10-4.61% of sorbitol, 1.09-4.62% of xanthan gum, 2.19-6.92% of sodium lauroyl sarcosine, 5.74-21.14% of hydroxyapatite, 0.11-1.17% of biological surface detergent, 1.08ppm-11.80ppm of silver, 5.61-17.66% of arginine, 0.11-0.71% of zinc citrate, 0.11-0.71% of cyclodextrin and 3.33-11.29% of water by mass. The preparation method comprises uniformly mixing calcium hydrogen phosphate dihydrate, sodium lauroyl sarcosinate, hydroxyapatite and silver to obtain a first mixture; uniformly mixing sorbitol, arginine, xanthan gum and water to obtain a second mixture; uniformly mixing a biological surface cleaning agent, zinc citrate, cyclodextrin and water to obtain a third mixture; and uniformly mixing the first mixture, the second mixture and the third mixture with sodium bicarbonate to obtain the antibacterial toothpaste. The invention has obvious sterilization effect, and has no toxicity and irritation.

Description

Antibacterial toothpaste and preparation method thereof
Technical Field
The invention relates to an antibacterial toothpaste and a preparation method thereof.
Background
The disease is most important when one brushes one's teeth as the first step in oral health maintenance, which seems to be a simple task. The cause of halitosis is mainly protein decomposition in oral cavity by some bacteria in oral cavity, resulting in some substances containing sulfide and having odor. The oral cavity and stomach problems are mostly caused by improper tooth cleaning, and even helicobacter pylori causing gastric cancer can be transmitted through the oral cavity. As a toothpaste product, the toothpaste is clean, mild and non-irritating, and can effectively kill bacteria harmful to human bodies and inhibit the growth of the bacteria. Therefore, toothpaste with strong cleaning capability and antibacterial and bacteriostatic capabilities is especially necessary.
Fluoride is commonly added into the existing toothpaste, and can directly inhibit energy metabolism required by bacterial growth in an oral cavity, inhibit adhesion of bacteria to tooth surfaces, inhibit activity of various enzymes in the bacterial metabolism process and enable the bacteria to grow, metabolize disorderly or stop.
However, it is considered that fluoride has some side effects, and it can reduce bone strength to cause osteoporosis, cause dental fluorosis, and reduce user's intelligence.
Disclosure of Invention
The invention aims to provide an antibacterial toothpaste which can resist bacteria and prevent and treat oral problems.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides an antibacterial toothpaste, which comprises 5.70-21.14% of sodium bicarbonate, 32.20-69.10% of calcium hydrogen phosphate dihydrate, 1.10-4.61% of sorbitol, 1.09-4.62% of xanthan gum, 2.19-6.92% of sodium lauroyl sarcosine, 5.74-21.14% of hydroxyapatite, 0.11-1.17% of biological surface detergent, 1.08-11.80 ppm of silver, 5.61-17.66% of arginine, 0.11-0.71% of zinc citrate, 0.11-0.71% of cyclodextrin and 3.33-11.29% of water by mass.
The preparation method comprises the following steps: uniformly mixing calcium hydrogen phosphate dihydrate, sodium lauroyl sarcosinate, hydroxyapatite and silver to obtain a first mixture;
uniformly mixing sorbitol, arginine, xanthan gum and water to obtain a second mixture;
uniformly mixing a biological surface cleaning agent, zinc citrate, cyclodextrin and water to obtain a third mixture;
and uniformly mixing the first mixture, the second mixture and the third mixture with sodium bicarbonate to obtain the antibacterial toothpaste.
The invention has the beneficial effects that: by adding the micro-nano silver into the antibacterial toothpaste, fluoride is avoided, the side effect of the antibacterial toothpaste is reduced, the growth of harmful microorganisms can be effectively inhibited, and the toothpaste is safe and nontoxic.
The foregoing is a summary of the present invention, and in order to provide a clear understanding of the technical means of the present invention and to be implemented in accordance with the present specification, the following is a preferred embodiment of the present invention and is described in detail below.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention. The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
The formula is as follows: 11.3 percent of sodium bicarbonate, 48.6 percent of calcium hydrogen phosphate dihydrate, 3.2 percent of sorbitol, 2.4 percent of xanthan gum, 3.2 percent of sodium lauroyl sarcosinate, 11.3 percent of hydroxyapatite, 0.5 percent of biosurfactant, 3ppm of silver, 9.72 percent of arginine, 0.3 percent of zinc citrate, 0.3 percent of cyclodextrin, 8.1 percent of water and 0.8 percent of mint in mass fraction.
The preparation method comprises the following steps:
uniformly mixing the calcium hydrogen phosphate dihydrate, the sodium lauroyl sarcosinate, the hydroxyapatite and the silver to obtain a first mixture;
uniformly mixing sorbitol, arginine, xanthan gum and water to obtain a second mixture;
uniformly mixing a biological surface cleaning agent, zinc citrate, cyclodextrin and water to obtain a third mixture;
and uniformly mixing the first mixture, the second mixture, the third mixture, sodium bicarbonate and mint, and subpackaging to obtain the antibacterial toothpaste.
In the embodiment, the mint is added, so that the antibacterial toothpaste has a mint flavor. The formula is suitable for most people, and the toothpaste has mint fragrance and can effectively inhibit the growth of harmful microorganisms, so that the root cause of halitosis is relieved.
Example 2
The formula is as follows: 7.9 percent of sodium bicarbonate, 56.4 percent of calcium hydrophosphate dihydrate, 3.3 percent of sorbitol, 2.3 percent of xanthan gum, 3.4 percent of sodium lauroyl sarcosinate, 11.2 percent of hydroxyapatite, 0.6 percent of biosurfactant, 3ppm of silver, 9 percent of arginine, 0.11 to 0.3 percent of zinc citrate, 0.11 to 0.3 percent of cyclodextrin, 3.3 percent of water and 0.6 percent of mint by mass fraction.
The preparation method comprises the following steps:
uniformly mixing the calcium hydrogen phosphate dihydrate, the sodium lauroyl sarcosinate, the hydroxyapatite and the silver to obtain a first mixture;
uniformly mixing sorbitol, arginine, xanthan gum and water to obtain a second mixture;
uniformly mixing a biological surface cleaning agent, zinc citrate, cyclodextrin and water to obtain a third mixture;
and uniformly mixing the first mixture, the second mixture, the third mixture, sodium bicarbonate and mint, and subpackaging to obtain the antibacterial toothpaste.
The formula is suitable for people with age and oral problems. Contains a large amount of biological surface cleaning agents of sodium lauroyl sarcosine and silver, and the biological surface cleaning agent is applied to toothpaste, not only has the decontamination effect, but also has the effects of inhibiting bacteria, improving the immunity of organisms and the like. The addition of sodium lauroyl sarcosinate in the toothpaste can reduce the dosage and improve the detergency of the toothpaste. Therefore, the antibacterial toothpaste can effectively kill harmful microorganisms in the oral cavity and relieve the problem of the oral cavity.
Example 3
The formula comprises 15.1 percent of sodium bicarbonate, 43 percent of calcium hydrophosphate dihydrate, 10.8 percent of hydroxyapatite, 2.2 percent of sorbitol, 2.2 percent of xanthan gum, 4.3 percent of sodium lauroyl sarcosinate, 0.2 percent of biosurfactant, 2ppm of silver, 10.8 percent of arginine, 0.2 percent of zinc citrate, 0.2 percent of cyclodextrin, 10.8 percent of water and 0.4 percent of natural fruit flavor by mass fraction.
The preparation method comprises the following steps:
uniformly mixing the calcium hydrogen phosphate dihydrate, the sodium lauroyl sarcosinate, the hydroxyapatite and the silver to obtain a first mixture;
uniformly mixing sorbitol, arginine, xanthan gum and water to obtain a second mixture;
uniformly mixing a biological surface cleaning agent, zinc citrate, cyclodextrin and water to obtain a third mixture;
and uniformly mixing the first mixture, the second mixture, the third mixture and the sodium bicarbonate natural fruit flavor, and subpackaging to obtain the antibacterial toothpaste.
The formula does not contain fluorine, has low content of each component, and is suitable for children and pregnant women.
Wherein, when in use, the silver is combined with oxygen metabolism enzyme to inactivate the enzyme and suffocate pathogenic bacteria. Whereas multicellular bodies do not use proteases for respiration. The antibacterial rate of the antibacterial agent to staphylococcus aureus, escherichia coli and oral cavity suppurative bacteria is up to more than 99%, and the antibacterial agent has the characteristics of no toxicity, no stimulation, no three causes and the like. Can effectively inhibit the growth of harmful microorganisms, thereby reducing the formation of dental plaque.
The hydroxyapatite has excellent biocompatibility, can be used as an induction factor of bones or teeth, and has better remineralization, desensitization and whitening effects on the teeth. Hydroxyapatite is used as an abrasive, and the particle diameter of the hydroxyapatite is generally 5-40 mu m. The abrasive is the main raw material of the toothpaste, generally accounts for 20-50% of the total amount of the formula, and has the most important functions of removing tartar and relieving dental calculus in the toothpaste. Wherein, HAP (hydroxyapatite) particles have good biocompatibility and high affinity with enamel, and the mineralization liquid can effectively form remineralization deposition, prevent calcium ion loss, solve the problem of enamel demineralization and fundamentally prevent dental caries. The toothpaste containing HAP has strong adsorption effect on salivary protein and dextran, can reduce dental plaque in oral cavity of patient, promote gingivitis healing, and has good prevention and treatment effect on dental caries and periodontal disease.
The humectant is one of the main components in the toothpaste, and has the main function of keeping moisture of the toothpaste body, and when the toothpaste is exposed to air, the moisture is prevented from evaporating, so that the toothpaste at the pipe opening is not easy to dry and is easy to extrude. It keeps the rheological property of the paste and is convenient for mechanical processing; the freezing point of the toothpaste is reduced, the azeotropic point of the toothpaste is improved, the water in the toothpaste body can not be separated when the toothpaste is melted after being frozen, and the toothpaste body is still stable even at high temperature (generally 50 ℃). Liquid sorbitol was used in the toothpaste in a mass fraction of 70%. The liquid sorbitol with the concentration is easy to crystallize, and the starch hydrolysis concentrated solution can be directly used for catalytic hydrogenation. Because the starch is not hydrolyzed completely, the method can produce liquid sorbitol containing sorbitol with the mass fraction of about 55 percent, polysaccharide (maltose) with the mass fraction of 6 percent to 8 percent, fructose and other components, and has very good freezing resistance. The CMC for the toothpaste is an aqueous solution with the mass fraction of 2 percent, and xanthan gum.
Sodium lauroyl sarcosinate has low oral toxicity and is safe for use in rinse-off cosmetics; when the concentration is not more than 5%, it is also safe for use in leave-on cosmetics. The sodium lauroyl sarcosine has higher safety and low irritation, and can be used for oral cleaning products for infants. Because the lauroyl sarcosine sodium foam is fine, lasting and low in irritation, the toothpaste has rich foam, and the use comfort is improved.
The biological surface cleaning agent is a metabolite secreted by microorganisms in a metabolic process under a certain condition and having certain surface activity, can be applied to the fields of medicines, foods, cosmetics, daily chemical industry, household care, fruit preservation and the like, has a decontamination effect, has the effects of inhibiting bacteria and improving the immunity of organisms and the like, and can reduce the dosage and improve the decontamination capability of toothpaste by matching sodium lauroyl sarcosine in the toothpaste.
The zinc citrate is used for toothpaste, has the functions of removing halitosis, smoke stain and dental calculus and diminishing inflammation, and the addition amount is generally 0.1-0.3%. Appearance: white powder, odorless and tasteless, soluble in ethanol and diethyl ether, soluble in dilute acid and alkali, slightly soluble in water, insoluble in benzene, and slightly soluble in chloroform. The zinc citrate is a traditional medicine for inhibiting dental plaque and calculus, inhibits the growth of dental calculus crystals by replacing calcium in calcium phosphate, prevents the formation of dental calculus, has an obvious antibacterial effect, and is a safe and effective anti-dental plaque and anti-calculus agent. Polyphosphates, zeolites, are also safe and effective anticalculus agents that act to prevent the initial conversion of amorphous calcium phosphate to crystalline hydroxyapatite. The tranexamic acid has effects of removing tartar under synergistic effect of surfactant, and also has antibacterial effect, and can be added into toothpaste as scale remover.
The cyclodextrin is applied to toothpaste, so that the stability of functional components and the addition amount of essence can be improved; the special odor can be eliminated and covered, and the effect of eliminating the oral odor can be obviously improved; can reduce bitter taste and improve toothpaste taste.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. An antibacterial toothpaste is characterized by comprising, by mass, 5.70-21.14% of sodium bicarbonate, 32.20-69.10% of calcium hydrogen phosphate dihydrate, 1.10-4.61% of sorbitol, 1.09-4.62% of xanthan gum, 2.19-6.92% of sodium lauroyl sarcosine, 5.74-21.14% of hydroxyapatite, 0.11-1.17% of biological surface detergent, 1.08-11.80 ppm of silver, 5.61-17.66% of arginine, 0.11-0.71% of zinc citrate, 0.11-0.71% of cyclodextrin and 3.33-11.29% of water.
2. The antibacterial toothpaste according to claim 1, wherein the silver is micro-nano silver.
3. The antibacterial toothpaste according to claim 1, wherein the particle fineness of calcium hydrogen phosphate dihydrate and hydroxyapatite is 5-20 μm.
4. The antibacterial toothpaste according to claim 1, wherein the antibacterial toothpaste further comprises a coloring agent.
5. The antiseptic dentifrice of claim 1 wherein said antiseptic dentifrice further comprises a sweetener.
6. The antibacterial toothpaste according to claim 1, wherein the antibacterial toothpaste further comprises an appearance modifier.
7. A method of preparing an antibacterial toothpaste according to claim 1, comprising:
uniformly mixing the calcium hydrogen phosphate dihydrate, the sodium lauroyl sarcosinate, the hydroxyapatite and the silver in mass fraction to obtain a first mixture;
uniformly mixing the sorbitol, the arginine, the xanthan gum and the water in mass fraction to obtain a second mixture;
uniformly mixing the biological surface cleaning agent, the zinc citrate, the cyclodextrin and the water in the mass fraction to obtain a third mixture;
and uniformly mixing the first mixture, the second mixture and the third mixture with sodium bicarbonate to obtain the antibacterial toothpaste.
8. The method of claim 7, wherein the step of uniformly mixing the first mixture, the second mixture, and the third mixture with sodium bicarbonate further comprises adding a colorant to the mixture of the first mixture, the second mixture, the third mixture, and the sodium bicarbonate.
9. The method of claim 7, wherein the step of uniformly mixing the first mixture, the second mixture, and the third mixture with sodium bicarbonate further comprises adding a sweetener to the mixture of the first mixture, the second mixture, the third mixture, and the sodium bicarbonate.
10. The method of claim 7, wherein the step of uniformly mixing the first mixture, the second mixture, and the third mixture with sodium bicarbonate further comprises adding an appearance modifier to the mixture of the first mixture, the second mixture, the third mixture, and the sodium bicarbonate.
CN202110167631.2A 2021-02-07 2021-02-07 Antibacterial toothpaste and preparation method thereof Pending CN112691045A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110167631.2A CN112691045A (en) 2021-02-07 2021-02-07 Antibacterial toothpaste and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110167631.2A CN112691045A (en) 2021-02-07 2021-02-07 Antibacterial toothpaste and preparation method thereof

Publications (1)

Publication Number Publication Date
CN112691045A true CN112691045A (en) 2021-04-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110167631.2A Pending CN112691045A (en) 2021-02-07 2021-02-07 Antibacterial toothpaste and preparation method thereof

Country Status (1)

Country Link
CN (1) CN112691045A (en)

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