CN110859765A - Fluorinated foam for preventing dental caries - Google Patents
Fluorinated foam for preventing dental caries Download PDFInfo
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- CN110859765A CN110859765A CN201911305063.7A CN201911305063A CN110859765A CN 110859765 A CN110859765 A CN 110859765A CN 201911305063 A CN201911305063 A CN 201911305063A CN 110859765 A CN110859765 A CN 110859765A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Life Sciences & Earth Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
An anticariogenic fluorinated foam characterized by comprising: foaming agent, humectant, acidifier, water-soluble fluoride, sweetener and essence, propellant and pure water constitute, its characterized in that: water-soluble fluorinated foam is arranged in the aerosol container, and the extruded product is in a white fine foam shape and has no fluidity, and the pH value is 4.0-6.0; wherein: the water-soluble fluoride comprises sodium fluoride, stannous fluoride and sodium monofluorophosphate, and the acidifier comprises strontium chloride, ethyl linoleate and sodium lauryl sulfate.
Description
The technical field is as follows:
the invention belongs to the field of medical instruments, and particularly relates to an anti-caries fluorinated foam.
Background art:
at present, fluoride is widely applied to dental treatment, and fluorine can be combined with a tooth crystal structure-hydroxyapatite to change the tooth crystal structure, resist acid etching and prevent dental caries. Dental caries is a frequently encountered disease in dentistry, the morbidity of children in China at present reaches more than 90% according to data statistics, and various fluoride compounds are applied to the treatment of dental caries, are prepared into gel, mouthwash, toothpaste, tooth powder and the like and are applied to local caries prevention. However, due to the limitations of these products, the fluoride ion in the fluoride does not reach the maximum free state, which affects the absorption and exchange of enamel, and the effect is not ideal, and wastes manpower and material resources.
In recent years, people develop population prevention and treatment work in large area by using fluorine-containing anti-caries products in China, and the safety of the products is more and more concerned. The formula of the product only considers the anti-caries effect of sodium fluoride, but does not consider the problems of instability of single fluorine ions and poor reliability on product quality, and the fluorine content of the product reaches 12,300PPM, which is greatly more than 10 times of the safety standard of 1,200PPM, so the product is toxic and has the risk of serious allergy.
The domestic formula of the caries-preventing fluorinated foam with the application publication number CN1172647 is not comprehensive in component consideration, and in addition, the water-soluble fluorinated foam and the manufacturing method with the application publication number CN1792359 are complicated in processing method and are not beneficial to saving the production cost.
Aiming at the situation, the inventor researches a cariostatic fluorinated foam.
The invention content is as follows:
in order to achieve the above object, the present invention provides an anticaries fluorinated foam which has been achieved to reduce fluid loss and establish good wall building properties.
The technical scheme of the invention is as follows:
an anticariogenic fluorinated foam characterized by comprising: foaming agent, humectant, acidifier, water-soluble fluoride, sweetener and essence, propellant and pure water constitute, its characterized in that: the aerosol container is filled with water-soluble fluorinated foam, the product after extrusion is in a white fine foam shape and has no fluidity, the pH value is 4.0-6.0, the content of fluorine ions is 6000 x (1 +/-10%) ppm, 10000 x (1 +/-10%) ppm and 12300 x (1 +/-10%) ppm, wherein: the water-soluble fluoride comprises sodium fluoride, stannous fluoride and sodium monofluorophosphate, and the acidifier comprises strontium chloride, ethyl linoleate and sodium lauryl sulfate.
Preferably, the content of the sodium fluoride is 0.01-0.015%, the content of the stannous fluoride is 0.02-0.03%, the content of the sodium monofluorophosphate is 0.01-0.02%, the content of the strontium chloride is 0.01-10%, the content of the ethyl linoleate is 0.01-1%, and the content of the sodium lauryl sulfate is 0.01-10%.
Preferably, the content of the foaming agent is 0.08-0.13%, the content of the humectant is 0.13-0.14%, the content of the acidifying agent is 0.015-0.025%, the content of the sweetener is 0.015-0.025%, the content of the essence is 0.015-0.016%, the content of the propellant is 0.05-0.09%, and the balance is pure water added to 100%.
Preferably, the humectant is a mixture of amino acid pyrolidocarboxylacid, sodium lactate and Urea Urea, and the three are mixed according to the ratio of 1:1: 1.
Preferably, the method for manufacturing the anticarious fluorinated foam is characterized by comprising the following manufacturing steps:
step 1, preparing raw materials according to a formula proportion for later use;
and 2, respectively pouring water-soluble fluorides such as sodium fluoride, stannous fluoride and sodium monofluorophosphate, acidifier such as strontium chloride, ethyl linoleate and sodium lauryl sulfate into a vessel for slow heating, heating for 1-5 minutes and stirring at a low speed, wherein the rotating speed of a motor is 500-1500 rpm, heating for 5-10 minutes and stirring at a medium speed, wherein the rotating speed of the motor is 600-1000 rpm, heating to 70 ℃, heating for 10-15 minutes and stirring at a high speed, wherein the rotating speed of the motor is 1000-1500 rpm, heating to 95 ℃, and controlling the temperature.
And 3, pouring all the rest components into the vessel after the temperature is constant, stirring for 90-120 minutes at constant temperature, and clarifying the solution.
And 4, after the solution is clarified, opening condensed water, cooling to room temperature, and bottling for sale.
The invention has the following beneficial effects:
the invention relates to an anticarious fluorinated foam, which is a product after being extruded into white fine foam without fluidity, wherein the pH value is 4.0-6.0, the content of fluorine ions is 6000 x (1 +/-10%) ppm, 10000 x (1 +/-10%) ppm and 12300 x (1 +/-10%) ppm, wherein: the water-soluble fluoride is sodium fluoride, stannous fluoride and sodium monofluorophosphate, the acidifier is strontium chloride, ethyl linoleate and sodium lauryl sulfate, the effective fluoride ion concentration of the product is ensured, fluoride ions are maximally diffused and dissociated, the absorption and exchange of enamel are facilitated, the decayed tooth prevention effect is durable, the use is safer, and the water-soluble fluoride is particularly suitable for the group prevention and treatment of the juvenile decayed tooth disease. Has the characteristics of simple and convenient operation, good effect, low cost and the like, and is suitable for popularization and use by the whole people.
The outer package of the product is composed of an aluminum spraying tank internally attached with a high molecular inner membrane, and is economical, environment-friendly and high-pressure resistant.
The specific implementation mode is as follows:
an anticariogenic fluorinated foam characterized by comprising: foaming agent, humectant, acidifier, water-soluble fluoride, sweetener and essence, propellant and pure water constitute, its characterized in that: the aerosol container is filled with water-soluble fluorinated foam, the product after extrusion is in a white fine foam shape and has no fluidity, the pH value is 4.0-6.0, the content of fluorine ions is 6000 x (1 +/-10%) ppm, 10000 x (1 +/-10%) ppm and 12300 x (1 +/-10%) ppm, wherein: the water-soluble fluoride comprises sodium fluoride, stannous fluoride and sodium monofluorophosphate, and the acidifier comprises strontium chloride, ethyl linoleate and sodium lauryl sulfate.
In a preferred embodiment of the present invention, the content of sodium fluoride is 0.01% to 0.015%, the content of stannous fluoride is 0.02% to 0.03%, the content of sodium monofluorophosphate is 0.01% to 0.02%, the content of strontium chloride is 0.01% to 10%, the content of ethyl linoleate is 0.01% to 1%, and the content of sodium lauryl sulfate is 0.01% to 10%.
In a preferred embodiment of the present invention, the content of the foaming agent is 0.08% -0.13%, the content of the humectant is 0.13% -0.14%, the content of the acidifying agent is 0.015% -0.025%, the content of the sweetener is 0.015% -0.025%, the content of the essence is 0.015% -0.016%, the content of the propellant is 0.05% -0.09%, and the balance is pure water added to 100%.
In a preferred embodiment of the invention, the humectant is a mixture of amino acid pyrolidonecarboyl acid, sodium lactate and Urea, and the three are mixed in a ratio of 1:1: 1.
In a preferred embodiment of the present invention, the method for producing the anticaries fluorinated foam is characterized by comprising the following steps:
step 1, preparing raw materials according to a formula proportion for later use;
and 2, respectively pouring water-soluble fluorides such as sodium fluoride, stannous fluoride and sodium monofluorophosphate, acidifier such as strontium chloride, ethyl linoleate and sodium lauryl sulfate into a vessel for slow heating, heating for 1-5 minutes and stirring at a low speed, wherein the rotating speed of a motor is 500-1500 rpm, heating for 5-10 minutes and stirring at a medium speed, wherein the rotating speed of the motor is 600-1000 rpm, heating to 70 ℃, heating for 10-15 minutes and stirring at a high speed, wherein the rotating speed of the motor is 1000-1500 rpm, heating to 95 ℃, and controlling the temperature.
And 3, pouring all the rest components into the vessel after the temperature is constant, stirring for 90-120 minutes at constant temperature, and clarifying the solution.
And 4, after the solution is clarified, opening condensed water, cooling to room temperature, and bottling for sale.
The results of the use show that:
the product of the invention has the following notes:
do not eat.
It is not suitable for children under three years old, and people with allergic constitution, common cold, fever, gastropathy or gastrointestinal discomfort.
The product of the invention does not approach the fire source.
The product of the invention is preserved in a shady and cool place and has a validity period of three years.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes and modifications may be made in the formulation of the embodiments without departing from the spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. An anticariogenic fluorinated foam characterized by comprising: foaming agent, humectant, acidifier, water-soluble fluoride, sweetener and essence, propellant and pure water constitute, its characterized in that: the aerosol container is filled with water-soluble fluorinated foam, the product after extrusion is in a white fine foam shape and has no fluidity, the pH value is 4.0-6.0, the content of fluorine ions is 6000 x (1 +/-10%) ppm, 10000 x (1 +/-10%) ppm and 12300 x (1 +/-10%) ppm, wherein: the water-soluble fluoride comprises sodium fluoride, stannous fluoride and sodium monofluorophosphate, and the acidifier comprises strontium chloride, ethyl linoleate and sodium lauryl sulfate.
2. An anticariogenic fluorinated foam according to claim 1, characterized in that: the content of the sodium fluoride is 0.01-0.015%, the content of the stannous fluoride is 0.02-0.03%, the content of the sodium monofluorophosphate is 0.01-0.02%, the content of the strontium chloride is 0.01-10%, the content of the ethyl linoleate is 0.01-1%, and the content of the sodium lauryl sulfate is 0.01-10%.
3. An anticariogenic fluorinated foam according to claim 1, characterized in that: the foaming agent comprises 0.08-0.13% of foaming agent, 0.13-0.14% of humectant, 0.015-0.025% of acidifying agent, 0.015-0.025% of sweetening agent, 0.015-0.016% of essence, 0.05-0.09% of propellant and the balance of pure water added to 100%.
4. An anticariogenic fluorinated foam according to claim 1, characterized in that: the humectant is a mixture of amino acid pyrolidocarboxylacid, sodium lactate Sodiumlactate and Urea Urea, and the three are mixed according to the ratio of 1:1: 1.
5. The method for preparing fluorinated foam for preventing dental caries according to claim 1, wherein the preparation steps are as follows:
step 1, preparing raw materials according to a formula proportion for later use;
and 2, respectively pouring water-soluble fluorides such as sodium fluoride, stannous fluoride and sodium monofluorophosphate, acidifier such as strontium chloride, ethyl linoleate and sodium lauryl sulfate into a vessel for slow heating, heating for 1-5 minutes and stirring at a low speed, wherein the rotating speed of a motor is 500-1500 rpm, heating for 5-10 minutes and stirring at a medium speed, wherein the rotating speed of the motor is 600-1000 rpm, heating to 70 ℃, heating for 10-15 minutes and stirring at a high speed, wherein the rotating speed of the motor is 1000-1500 rpm, heating to 95 ℃, and controlling the temperature.
And 3, pouring all the rest components into the vessel after the temperature is constant, stirring for 90-120 minutes at constant temperature, and clarifying the solution.
And 4, after the solution is clarified, opening condensed water, cooling to room temperature, and bottling for sale.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911305063.7A CN110859765A (en) | 2019-12-17 | 2019-12-17 | Fluorinated foam for preventing dental caries |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911305063.7A CN110859765A (en) | 2019-12-17 | 2019-12-17 | Fluorinated foam for preventing dental caries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110859765A true CN110859765A (en) | 2020-03-06 |
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ID=69659646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911305063.7A Pending CN110859765A (en) | 2019-12-17 | 2019-12-17 | Fluorinated foam for preventing dental caries |
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| Country | Link |
|---|---|
| CN (1) | CN110859765A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177543A (en) * | 2022-08-31 | 2022-10-14 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and anticarious composition containing L-lactate, oral care product and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172647A (en) * | 1996-08-06 | 1998-02-11 | 吴海元 | Dental caries prevention fluoration foam |
| CN1175399A (en) * | 1996-09-03 | 1998-03-11 | 蔺万斯 | Fluorinated foam |
| CN1792359A (en) * | 2005-08-15 | 2006-06-28 | 北京鑫源恒信医疗器械有限公司 | Water soluble fluoridized foam, and its prepn. method |
| JP2007137773A (en) * | 2005-11-14 | 2007-06-07 | Sunstar Inc | Foam-formed fluorine-applying agent |
| US20090087391A1 (en) * | 2007-10-01 | 2009-04-02 | Marilou Theresa Joziak | Foamable fluoride oral care composition |
-
2019
- 2019-12-17 CN CN201911305063.7A patent/CN110859765A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172647A (en) * | 1996-08-06 | 1998-02-11 | 吴海元 | Dental caries prevention fluoration foam |
| CN1175399A (en) * | 1996-09-03 | 1998-03-11 | 蔺万斯 | Fluorinated foam |
| CN1792359A (en) * | 2005-08-15 | 2006-06-28 | 北京鑫源恒信医疗器械有限公司 | Water soluble fluoridized foam, and its prepn. method |
| JP2007137773A (en) * | 2005-11-14 | 2007-06-07 | Sunstar Inc | Foam-formed fluorine-applying agent |
| US20090087391A1 (en) * | 2007-10-01 | 2009-04-02 | Marilou Theresa Joziak | Foamable fluoride oral care composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177543A (en) * | 2022-08-31 | 2022-10-14 | 重庆登康口腔护理用品股份有限公司 | Antibacterial and anticarious composition containing L-lactate, oral care product and preparation method and application thereof |
| CN115177543B (en) * | 2022-08-31 | 2024-01-09 | 重庆登康口腔护理用品股份有限公司 | Antibacterial caries preventing composition containing L-lactate, oral care product and preparation method and application thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200306 |