CN112315827B

CN112315827B - Oral care composition and application

Info

Publication number: CN112315827B
Application number: CN202011023847.3A
Authority: CN
Inventors: 谢森奎; 陈晓斌
Original assignee: Hawley & Hazel Bvi Co ltd
Current assignee: Hawley & Hazel Bvi Co ltd
Priority date: 2020-09-25
Filing date: 2020-09-25
Publication date: 2023-02-28
Anticipated expiration: 2040-09-25
Also published as: CN112315827A

Abstract

The invention discloses an oral care composition and application thereof, wherein the oral care composition comprises 1) soluble zinc, 2) carbomer and 3) an orally acceptable carrier; the detectable concentration of the soluble zinc in the oral care composition is greater than or equal to 45ppm. The oral care composition can not only keep the concentration of soluble zinc in the composition, but also reduce the uncomfortable astringent taste of the soluble zinc, so that the composition can better play an antibacterial role, and the use of the composition is not limited by the taste; the composition of the invention can also effectively improve the retention time of zinc in the oral cavity.

Description

Oral care composition and application

Technical Field

The invention relates to the technical field of oral care, in particular to an oral care composition and application thereof.

Background

Zinc ions, especially in the soluble state, have a good antibacterial effect and have a long history of use in the field of oral care. For example: chinese patent application CN 102378627A, entitled "antimicrobial composition comprising 4-isopropyl-3 methylphenol and zinc ions" discloses an improvement of antimicrobial activity in a composition comprising IPMP (4-isopropyl-3 methylphenol), a zinc ion source and an anionic surfactant; further, the document found that compositions comprising IPMP have intrinsic anti-inflammatory activity, which is enhanced by the presence of a zinc ion source.

Chinese patent application CN 1649560A, entitled "antimicrobial fresh breath mouthrinse", discloses a mouthrinse containing CPC, zinc ions. It has antibacterial effect, and can remove bacteria in oral cavity which can produce odor.

Chinese patent application CN 110123669A, entitled "oral compositions containing metal ions", discloses an oral care composition containing a stannous ion source, a zinc ion source, a polyphosphate, and a thickening agent. The compositions disclosed in this document contain a zinc compound which provides a source of zinc ions. And discloses that zinc ions help reduce gingivitis, plaque, sensitivity and improve respiratory benefits. The zinc compound may be a soluble or poorly soluble zinc compound with an inorganic or organic counterion. Examples include fluorides, chlorides, chlorofluorides, acetates, hexafluorozirconates, sulfates, tartrates, gluconates, citrates, lactates, malates, glycinates, pyrophosphates, metaphosphates, oxalates, phosphates, carbonates, zinc oxides, and the like of zinc.

While zinc ions in a soluble state have found widespread use in oral care compositions, the inclusion of zinc ions in a soluble state in oral care compositions results in an unpleasant astringent taste, which limits the use of zinc salts in oral care products.

Disclosure of Invention

The invention provides an oral care composition. The oral care composition can not only retain the concentration of soluble zinc in the composition, but also reduce the unpleasant astringent taste of soluble zinc, so that the composition can better exert antibacterial effect, and the use of the composition is not limited by the taste.

A second technical problem to be solved by the present invention is to provide the use of carbomers for reducing the astringency of soluble zinc in an oral care composition.

In order to solve the first technical problem, the invention adopts the following technical scheme:

an oral care composition comprising:

1) The zinc is soluble in the water, and the zinc,

2) Carbomer, and

3) An orally acceptable carrier;

the detectable concentration of the soluble zinc in the oral care composition is greater than or equal to 45ppm.

According to certain embodiments of the present application, the weight percentage of the carbomer in the oral care composition is 0.05% or more.

According to certain embodiments of the present application, the detectable concentration of the soluble zinc in the oral care composition is from 45ppm to 1900ppm.

According to certain embodiments of the present application, the soluble zinc is derived from one or a combination of more than one of zinc citrate, zinc sulfate, zinc nitrate, zinc oxide, zinc gluconate.

According to certain embodiments of the present application, the carbomer is one or a combination of more than one of carbopol 956, carbopol 981, carbopol 974.

According to certain embodiments of the present application, the carbomer compound is present in the oral care composition in an amount from 0.05% to 1.1% by weight.

According to certain preferred embodiments of the present application, the carbomer is present in the oral care composition in an amount from 0.1% to 0.8% by weight.

According to certain embodiments of the present application, the oral care composition further comprises a polyphosphate.

According to certain embodiments of the present application, the polyphosphate is one or a combination of more than one of pyrophosphate, tripolyphosphate, hexametaphosphate.

According to certain embodiments of the present application, the polyphosphate is present in an oral care composition in an amount of 0.1% to 8% by weight.

According to certain embodiments of the present application, the oral care composition is a toothpaste, gel, tooth powder or mouthwash.

To solve the second technical problem, the present invention provides the use of carbomer for reducing the astringency of soluble zinc in an oral care composition.

Any range recited herein is intended to include any and all subranges between the endpoints and any subrange between the endpoints or any subrange between the endpoints.

The starting materials of the present invention are commercially available, unless otherwise specified, and the equipment used in the present invention may be any equipment conventionally used in the art or may be any equipment known in the art.

Compared with the prior art, the invention has the following beneficial effects:

the oral care compositions of the present invention maintain the concentration of soluble zinc in the composition while reducing the unpleasant astringent taste of soluble zinc. The composition of the invention can also effectively improve the retention time of zinc in the oral cavity.

Detailed Description

In order to more clearly illustrate the invention, the invention is further described below in connection with preferred embodiments. It is to be understood by persons skilled in the art that the following detailed description is illustrative and not restrictive, and is not to be taken as limiting the scope of the invention.

All percentages and ratios used herein are by weight of the total composition, unless otherwise specified. Unless otherwise indicated, all percentages, ratios, and levels of ingredients referred to herein are based on the actual amount of the ingredient, and do not include solvents, fillers, or other materials found in commercially available products with which the ingredient may be combined.

The term "comprising" as used herein means that other steps and ingredients which do not affect the end result can be added.

The term "preferably" and its variants herein refer to embodiments of the invention that are capable of providing specific benefits under specific circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the detailed description of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the invention.

The method is carried out according to conventional conditions or conditions recommended by manufacturers if specific conditions are not indicated in the examples of the invention; the reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

As one aspect of the present invention, an oral care composition comprises:

1) The zinc can be dissolved in the water, and the zinc,

2) Carbomer, and

3) An orally acceptable carrier;

Carbomers are also commonly used in oral care compositions in the prior art, either as thickeners or binders. It has been unexpectedly discovered that the addition of carbomer to an oral care composition containing soluble zinc can reduce the astringent taste caused by free zinc ions while maintaining a detectable concentration of soluble zinc.

Soluble zinc

By "soluble zinc" is meant herein: zinc which can be present in a solvent (e.g. water) or a base (e.g. toothpaste) without being present as a precipitate. Soluble zinc can include zinc in ionic form, zinc in complex or chelate form, and zinc in dispersible combination (detectable) when dispersed in a solvent or matrix. Soluble zinc is largely distinguished from zinc which is present in insoluble form, such as zinc in solid zinc oxide.

In certain embodiments, the soluble zinc is derived from one or a combination of more than one of zinc citrate, zinc sulfate, zinc nitrate, zinc oxide, zinc chloride, zinc gluconate.

In the present application, the soluble zinc concentration can be determined by methods known to those skilled in the art, such as atomic absorption spectroscopy, inductively coupled plasma emission spectroscopy, and the like. In certain embodiments, the soluble zinc concentration is tested using inductively coupled plasma emission spectroscopy (ICP-AES). The method is that the solution to be measured forms aerosol through an atomizing device, the aerosol is sprayed into a plasma torch through a quartz tube, a sample is decomposed to form an excited atomic and ionic state, certain energy is emitted when the excited particles return to a stable ground state, the excited particles are expressed as a spectrum with certain wavelength, the specific spectral line and the specific intensity of each element are measured, and the type and the amount of the elements contained in the sample can be known compared with a standard solution.

A method for detecting soluble zinc concentration by inductively coupled plasma emission spectroscopy, generally comprising the steps of:

1) Sample processing method

Toothpaste, gel and dentifrice treatment methods the amount of oral saliva secreted during brushing was simulated and samples were tested at a 1: diluting with water at a ratio of 2, namely accurately weighing 10g of oral care composition sample and 20g of deionized water, mixing, stirring for 5min by using a magnetic stirrer to obtain toothpaste slurry, centrifuging, taking supernate, and digesting the supernate to completely digest organic matters in the supernate. Digestion may be carried out using any suitable method known in the art, including but not limited to digestion using high purity concentrated nitric acid, or microwave digestion, etc., as long as the organic matter in the supernatant is completely digested and no additional zinc source is introduced;

method for treating mouthwash the sample can be digested directly by any suitable method known in the art, including but not limited to digestion with concentrated, high purity nitric acid, or microwave digestion, etc., as long as the organic matter in the mouthwash solution is completely digested and no other zinc source is introduced;

2) Sample testing

And (4) testing the emission line and the intensity of the zinc element in the obtained digestion product, and comparing the emission line and the intensity with a standard curve of a zinc ion standard solution to deduce the concentration of soluble zinc in the sample.

In certain embodiments of the present application, the soluble zinc is detectable in the oral care composition at a concentration of ≥ 45ppm, such as but not limited to 45ppm to 1900ppm, or 50ppm to 1880ppm, or 60ppm to 1800ppm, or 70ppm to 1700ppm, or 80ppm to 1600ppm, or 90ppm to 1500ppm, or 100ppm to 1200ppm, or 200ppm to 1000ppm, or 300ppm to 900ppm, or 400ppm to 800ppm, or 500ppm to 600ppm, or 45ppm to 500ppm, or 50ppm to 400ppm, or 60ppm to 300ppm, or 70ppm to 250ppm, or 80ppm to 200ppm, or 90ppm to 100ppm.

Carbomer

Carbomer is a polymer formed by chemically crosslinking acrylic acid or acrylic ester and allyl ether, is a very important rheology regulator, and neutralized carbomer is an excellent gel matrix and has important applications of thickening, suspension and the like, and the carbomer has the advantages of simple preparation process, good stability and wide application in emulsion, cream and gel. Carbomer is one of the leading products of the U.S. knowlett packard company. Carbomers are commonly used as thickening agents in oral care compositions.

The present application has unexpectedly found that carbomers can effectively reduce the astringent taste caused by soluble zinc, and that carbomers can increase the amount and residence time of the zinc ion source on the tooth surface.

The following is a description of a commonly used carbomer series:

carbopol 940: short rheology, high viscosity, high clarity, low ion and shear resistance, and is suitable for use in gels and creams.

Carbopol 941: long rheology, low viscosity, high clarity, medium resistance to ions and shear, and suitability for gels and emulsions.

Carbopol 980: cross-linked polyacrylic resins, topical delivery systems, crystalline clear gels, water or alcoholic solvents.

Carbomer 981: crosslinked polyacrylic acid resin. It features similar to Carbomer 941, long rheological property, low viscosity, high transparency and high suspension stability, but its polymerizing solvent system is ethyl acetate and cyclohexane.

As a preferred embodiment herein, the carbomer is one or a combination of more than one of carbopol 956, carbopol 981, and carbopol 974.

In certain preferred embodiments of the present application, the Carbopol is selected from the commercial products available under the trade name Carbopol from Lubrizol LifeSciences company.

In certain embodiments of the present application, the carbomer further comprises the neutralized product of the carbomer copolymer with a base, including, but not limited to, sodium hydroxide, potassium hydroxide.

In certain embodiments of the application, the weight percentage of the carbomer in the oral care composition is 0.05% or more, such as, but not limited to, 0.05 to 1.1%,0.05 to 0.8%, or 0.05 to 0.6%, or 0.05 to 0.4%, or 0.05 to 0.2%, or 0.05 to 0.1%, or 0.1 to 1%, or 0.1 to 0.8%, or 0.1 to 0.6%, or 0.1 to 0.4%, or 0.1 to 0.2%, or 0.3 to 1%, or 0.3 to 0.8%, or 0.3 to 0.6%, or 0.3 to 0.4%, or 0.5 to 1%, or 0.5 to 0.8%, or 0.5 to 0.6%, or 0.7 to 1%. The addition amount of the carbomer is not high (preferably not more than 1.1%), too high carbomer content can cause the resistance which is difficult to overcome when a stirring paddle of a reaction kettle of a product is stirred, and paste is difficult to pack and extrude in the later period.

Polyphosphate salt

It has been unexpectedly discovered that by adding carbomer to an oral care composition comprising soluble zinc, carbomer can significantly reduce the astringent taste caused by soluble zinc, and polyphosphate can further reduce the astringent taste of soluble zinc on the basis of carbomer.

According to certain embodiments of the invention, the polyphosphate is selected from a combination of one or both of alkali metal salts, such as sodium or potassium salts, of polyphosphoric acid.

According to certain embodiments of the invention, the polyphosphate is a combination of one or more of pyrophosphate, tripolyphosphate, or hexametaphosphate.

According to certain embodiments of the invention, the polyphosphate is present in the oral care composition in an amount which is conventional, for example in a mass ratio of 0.01 to 8%, preferably 0.5 to 5%, or 0.5 to 4%, or 1 to 3.5%, or 1.5 to 3%, or 2 to 3%.

Orally acceptable carrier

In the present invention, the "orally acceptable carrier" refers to any vehicle suitable for formulating the oral care compositions disclosed herein; (ii) is not harmful to the mammal when the orally acceptable carrier is retained in the mouth in the amounts disclosed herein without swallowing for a period of time sufficient to allow effective contact with the tooth surface as required by the present invention; overall, an orally acceptable carrier is not harmful if not intentionally swallowed; suitable orally acceptable carriers include, for example, one or more of water, thickening agents, buffering agents, humectants, surfactants, abrasives, sweeteners, flavoring agents, visual aids (e.g., colors, dyes, or mixtures thereof), anti-caries agents, antibacterial agents, whitening agents, desensitizing agents, vitamins, preservatives, enzymes, mixtures thereof, and the like.

According to certain embodiments of the present application, the oral care composition further comprises an adjunct such as a humectant, a flavoring agent, and/or a thickening agent.

"humectants" are ingredients that prevent the hardening of an oral care composition by dehydration. Exemplary humectants include, but are not limited to, glycerin, propylene glycol, sorbitol, and the like. The humectant is typically present in the oral care composition in an amount of 10 to 80% by mass.

A "thickener" is a substance that increases the viscosity of a solution or liquid/solid mixture, but does not substantially change its properties. The purpose of the thickener is to provide skeleton, flow and stability to the product. Exemplary thickening agents include, but are not limited to, one or more of hydroxyethylcellulose, carboxymethylcellulose and salts thereof (e.g., sodium carboxymethylcellulose), carboxyvinyl polymers, xanthan gum (xanthan g μm), carrageenan, gelatin, pullulan, sodium alginate, and the like. In certain embodiments, the thickening agent comprises one or more of xanthan gum, carrageenan, or sodium carboxymethyl cellulose. The proportion by weight of thickener in the oral care composition is typically from 0.2 to 2%.

According to certain preferred embodiments of the present application, the oral care composition may further comprise active ingredients such as antibacterial agents, anticaries agents, anti-sensitivity agents, and/or whitening agents.

By "antibacterial agent" is meant a chemical substance that is capable of maintaining the growth or reproduction of certain microorganisms in an oral care composition below a necessary level over a period of time. Exemplary antibacterial agents include, but are not limited to, stannous chloride, tetrahydrocurcumin, cetylpyridinium chloride, triclosan, and the like.

"anticaries agent" means a substance having a cariogenic inhibitory action, for example, a substance which enhances the anticaries ability of teeth by decreasing the solubility of enamel hydroxyapatite, or controlling plaque, inhibiting bacterial growth, calcium caseinate, etc.), or arginine and its derivatives.

An "anti-sensitivity agent" refers to a substance that prevents or treats dentinal hypersensitivity by inhibiting nerve impulses or being capable of closing or decreasing the permeability of dentinal tubules. Exemplary anti-sensitivity agents include, but are not limited to, potassium ion sources such as dipotassium glycyrrhizinate, potassium fluoride, potassium nitrate, potassium chloride, and the like.

"whitening agent" means a substance that has the effect of whitening teeth. Exemplary whitening agents include, but are not limited to, peroxide bleaches.

As another aspect of the invention, the invention provides the use of a carbomer in reducing the astringency of soluble zinc in an oral care composition.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

Method for evaluating astringent taste

1) Evaluation group establishment

Selecting 30 qualified feeling evaluators according to GB/T16291.1-2012 and GB/T12311-2012;

2) Correction of astringency evaluation criteria by evaluation staff of evaluation criteria

Accurately weighing 0.010g, 0.025g and 0.05g of grape tannin, adding the grape tannin into 500ml of purified water, uniformly stirring, and then using the purified water to fix the volume to 1L, wherein the astringent strengths are respectively 2 min, 7 min and 13 min, and the astringent strength of the water is 0 min;

taking 20mL of the reference sample solution respectively, fully gargling for 30s, spitting out (not gargling with clear water), evaluating the astringency strength in the cavity at the moment, evaluating by an evaluator on a 15cm scale according to the feeling of the evaluator, repeating the steps for three times, and averaging the results of the three times to enable the evaluator to memorize the grading strength of the evaluator. Then, calculating the evaluation result of the reference sample of each evaluator according to a comprehensive rescaling method specified in a value estimation method of the national standard GB _ T19547-2004 to obtain a correction factor;

3) Sample evaluation

Sampling 1g of each sample, brushing teeth for 1min sufficiently, evaluating the astringent taste intensity in the oral cavity at the moment, and evaluating each evaluator on a 15cm scale according to the own feeling; the scale values of thirty evaluators were corrected by the above correction values, and then subjected to the evaluation results of variance analysis, and the obtained evaluation results were in accordance with statistical differences.

Example 1, comparative examples 1-2

Comparative examples 1-2, example 1 were configured according to the formulation of table 1:

TABLE 1 (in tables the percentages are by weight)

As can be seen from Table 1, comparative example 1 has only cellulose gum, a thickener, added and the detectable concentration of soluble zinc in the formulation is 25ppm; whereas the detectable concentration of soluble zinc in comparative example 2 was increased to 45ppm; example 1 is based on comparative example 2, carbomer is added, the viscosity of the paste is stabilized, the dosage of cellulose gum is reduced, and the detectable concentration of soluble zinc is 47ppm which is equivalent to that of comparative example 2.

From the astringency evaluation results, when the detectable concentration of soluble zinc was only 25ppm, the subject did not feel astringency of the paste; however, as the detectable concentration of soluble zinc in the formulation was increased to 45ppm, the consumer began to experience the astringent taste associated with soluble zinc; in example 1, however, the astringency score was reduced from 1.5 to 0 and no astringency of the formulation was perceived by the subject when carbomer was added to the formulation, although the detectable concentration of soluble zinc did not change.

Comparative examples 3 to 4

Comparative examples 3-4 were formulated according to table 2:

table 2 (the percentages in the table are percentages by weight of the raw materials)

For ease of comparison, the formulations of example 1 and comparative example 2 are shown in table 2.

As can be seen from table 2, comparative example 3 replaces the carbomer of example 1 with carrageenan and comparative example 4 replaces the carbomer of example 1 with xanthan gum, compared to example 1. From the astringency evaluation results, although carrageenan, xanthan gum and carbomer congener thickeners, both comparative example 3 and comparative example 4 did not reduce the astringent mouthfeel of the soluble zinc in the formulation. That is, not all thickeners reduce the astringent taste of soluble zinc, and only carbomers unexpectedly discovered herein have this function and effect.

Examples 2 to 6, comparative example 5

Examples 2-6 were formulated according to table 3, comparative example 5:

table 3 (the percentages in the table are by weight)

As can be seen from table 3: comparative example 5 formulation no carbomer was added, while examples 2-6 had carbomer contents of 0.1%,0.5%,0.8%,1.0%,1.1%, respectively, and the detectable concentrations of soluble zinc were substantially equivalent for the six formulations, but with increasing amounts of carbomer in the formulation, the astringency of the formulation was decreasing, but with increasing amounts of 0.8%, the decrease was significantly slowed. In addition, in the preparation process of the paste, when the addition amount of the carbomer in the formula is more than 1.1%, the stirring of the stirring paddle meets the resistance which is not easy to overcome, and the paste is not easy to be canned and extruded in the later period.

Examples 7 to 10, comparative examples 6 to 9

Examples 7-10, comparative examples 6-9 were formulated according to table 5:

table 4 (the percentages in the table are by weight)

From Table 4, it can be seen that the formulations of comparative examples 6-9 had no carbomer added and the detectable soluble zinc concentrations were 1598ppm,1023ppm,573ppm and 125pmm, respectively, and that examples 7-10 had carbomer added to the formulations of comparative examples 6-9 and the amount of cellulose gum correspondingly reduced. The formulations of examples 7-10, which had detectable soluble zinc concentrations of 1568ppm,1035ppm,569ppm and 129ppm, did not change much from those of comparative examples 6-9, but the astringency scores of the formulations were all significantly reduced. Astringency score 13 points for comparative example 6, but only 8.4 points for the corresponding example 7; astringency score 13 points for comparative example 7, but only 7.6 points for the corresponding example 8; the astringency score of comparative example 8 was 8.7 points, but the astringency score of the corresponding example 9 was only 4.9 points; the astringency score of comparative example 9 was 5.2 points, but the astringency score of the corresponding example 10 was only 2.9 points; thus, carbomer has a reducing effect on astringency caused by soluble zinc in different concentrations.

Examples 11 to 13

Examples 11-13 were formulated according to Table 5

Table 5 (the percentages in the table are percentages by weight of the raw materials)

For comparison, example 9 is shown in Table 5

As can be seen from Table 5, the formulation of example 11, when 2% zinc citrate and 0.8% sodium pyrophosphate were added, the detectable soluble zinc concentration of the formulation was 581ppm with an astringency score of 3.7; example 12 a formulation was prepared with 2% zinc citrate and 0.8% sodium tripolyphosphate with a detectable soluble zinc concentration of 632ppm and an astringency score of 3.6, and example 12 a formulation prepared with 2% zinc citrate and 0.8% sodium hexametaphosphate with a detectable soluble zinc concentration of 551ppm and an astringency score of 3.6; while the formulation of example 9 did not contain any polyphosphate, the detectable soluble zinc concentration was 569ppm, and it can be seen that while the formulations of examples 11-13 had higher soluble zinc concentrations than example 9 or comparable to example 9, the astringency score was lower than that of example 9.

Combining the evaluation results of the astringency of the formula: the polyphosphate can further reduce the astringent taste of soluble zinc on the basis of carbomer.

The method for detecting the retention of zinc ions in the oral cavity in the oral care composition of the present invention comprises:

1) And washing the HAp tablets with clear water, and drying at 40 ℃ for later use.

2) Taking 7 HAp sheets to a 14ml test tube, adding 10ml saliva supernatant sterilized by ultraviolet for 45 minutes, and soaking HAp in saliva; placing the test tube at 37 ℃ and shaking in a water bath to cultivate overnight;

3) Sample treatment: removing saliva in the test tube, immediately adding 3ml of toothpaste slurry into the test tube, sucking away the slurry after treating for 2 minutes, rinsing the HAp sheet with 5ml of deionized water for three times for 10 seconds;

4) Repeating the above experiment for 3 times to obtain 3 groups of HAp tablets;

5) And (3) putting a group of HAp sheets into a sterile tube filled with normal saline, fully and uniformly oscillating by using a vortex oscillator, removing the HAp sheets, and detecting the content of zinc ions in the sterile tube.

Example 14, comparative example 10

Example 14 and comparative example 10 were formulated according to table 6:

table 6 (the percentages in the table are percentages by weight of the raw materials)

TABLE 7 Retention of Zinc on HAp sheets in comparative example 10 and example 14 formulations

	Comparative example 10	Example 14
			Zinc content in HAp sheet	81.6ppm	145.2ppm

As can be seen from tables 6 and 7: comparative example 10, in which carbomer was not added, 1.5% of gantrez (maleic acid-methyl vinyl ether copolymer, PVM-MA) was added, and example 14, in which carbomer was added at 0.2%; from the results, the example 14 formulation retained significantly higher levels of zinc in the HAp sheets than the comparative example 10 formulation. That is, the compositions of the present invention are also effective in enhancing the retention and residence time of zinc in the oral cavity.

It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. All obvious changes and modifications which are obvious to the technical scheme of the invention are covered by the protection scope of the invention.

Claims

1. Use of a carbomer for reducing the astringency of soluble zinc in an oral care composition, wherein said oral care composition comprises:

1) The zinc can be dissolved in the water, and the zinc,

2) Carbomer, and

3) An orally acceptable carrier;

2. Use according to claim 1, characterized in that: the mass percentage of the carbomer in the oral care composition is more than or equal to 0.05%.

3. Use according to claim 1, characterized in that: the soluble zinc is present in the oral care composition in a detectable concentration of 45ppm to 1900ppm.

4. Use according to claim 1, characterized in that: the soluble zinc is one or more of zinc citrate, zinc sulfate, zinc nitrate, zinc chloride and zinc gluconate.

5. Use according to claim 1, characterized in that: the carbomer is one or more of carbopol 956, carbopol 981 and carbopol 974.

6. Use according to claim 1, characterized in that: the weight percentage of the carbomer in the oral care composition is 0.05% -1.1%.

7. Use according to claim 6, characterized in that: the carbomer is 0.1-0.8% by mass of the oral care composition.

8. Use according to claim 1, characterized in that: the oral care composition further comprises a polyphosphate.

9. Use according to claim 8, characterized in that: the polyphosphate is one or more of pyrophosphate, tripolyphosphate and hexametaphosphate.

10. Use according to claim 8, characterized in that: the mass percent of the polyphosphate in the oral care composition is 0.1-8%.

11. Use according to any one of claims 1 to 10, wherein: the oral care composition is a toothpaste, gel, dentifrice or mouthwash.